CN104940726A - Traditional Chinese medicine preparation for pulmonary alveolar proteinosis and preparation method of traditional Chinese medicine preparation - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for pulmonary alveolar proteinosis. The traditional Chinese medicine preparation is prepared from the following raw materials: astragalus membranaceus, rhodiola rosea, codonopsis pilosula, salvia miltiorrhiza, ligusticum wallichii, fried peach kernel, flowers carthami, angelica sinensis, rhizoma phragmitis, platycodon grandiflorum, chrysanthemum, red tangerine peel, raw semen coicis, semen lepidii, Chinese-date, lalang grass rhizome, root of kudzu vine, rhizoma polygonati, fried semen armeniacae amarae, flos farfarae, lily, radix glehniae, radix ophiopogonis, radix clematidis and raw liquorice. The invention belongs to the field of the traditional Chinese medicine. The raw materials are washed, chopped, pretreated, and prepared at the ratio according to different characteristics of each traditional Chinese medicine, and are prepared by a special method. The traditional Chinese medicine preparation has the effects of facilitating the lung, relieving sore throat, promoting qi circulation, relieving a cough, promoting blood circulation to restore menstrual flow, clearing away heat and calming the liver. The traditional Chinese medicine preparation is unique in combination and preparation method; and through clinical verification, the traditional Chinese medicine preparation is significant in treatment effect, short in treatment cycle, low in price and free of an adverse reaction or toxic or side effect, and has wide market application prospect.

Description

A kind of Chinese medicine preparation for pulmonary alveolar proteinosis and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for pulmonary alveolar proteinosis, the invention still further relates to the preparation method of this Chinese medicine preparation.

Background technology

Pulmonary alveolar proteinosis (PAP) is the not bright Uncommon Diseases of a kind of reason.Be characterized in having insolubility phospholipoprotein to deposit in alveolar, clinical symptoms main manifestations is for breathing hard, coughing and expectoration.Chest x-ray is in two lung diffusivity pulmonary infiltrates shade.Pathological examination is to be filled with the protein-like substance of periodic acid snow husband (PAS) stained positive for feature in alveolar.

Summary of the invention

The object of the present invention is to provide a kind of Chinese medicine preparation for pulmonary alveolar proteinosis, it is remarkable that this Chinese medicine preparation has therapeutic effect for treatment pulmonary alveolar proteinosis, and healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.

Inventor is in clinical treatment practice for many years, and according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out to be used for the treatment of the new formula of the Chinese medicine preparation of pulmonary alveolar proteinosis repeatedly.The present invention has that therapeutic effect is remarkable, and healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.

The effect of Chinese medicine of the present invention:

Wherein:

The Radix Astragali: be the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Nature and flavor: sweet, temperature.Return lung, spleen channel.Effect: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.

Radix Rhodiolae: be Crassulaceae Rhodida plant Radix Rhodiolae Rhodiola saera (Prain) Fu, with all herbal medicine.9 ~ October gathers, and cleans and dries.Nature and flavor: sweet, puckery, cold.Return lung meridian.Effect: clearing away lung-heat to relieve cough, hemostasis, leukorrhagia stopping.For cough due to lung-heat, spitting of blood, leucorrhea; Traumatic injury is controlled in external, burn and scald.

Radix Codonopsis: be the dry root of Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., element flower Radix Codonopsis (RADIX CODONOPSIS PILOSULAE from Northwest of China) Codonopsis pilosula Nannf. var. modesta (Nannf.) L. T. Shen or radix codonpsis tangshen Codonopsis tangshen Oliv..Nature and flavor: sweet are flat.Return spleen, lung meridian.Effect: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.

Radix Salviae Miltiorrhizae: be the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bunge..Nature and flavor: bitter, are slightly cold.GUIXIN, Liver Channel.Effect: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.Record in " the southern regions of the Yunnan Province book on Chinese herbal medicine ": reinforcing the heart sedate, calming heart and tranquilizing mind.Control forgetful punching seized with terror, palpitation with fear is insomnia.

Rhizoma Chuanxiong: be samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort.(or Ligusticum wallichii Franch.) dry rhizome.Nature and flavor: pungent, temperature.Return liver, gallbladder, pericardium channel.Effect: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Record in " Japan hanako materia medica ": control a wind cutting, all gas, all strains, all blood, mend five kinds of over strain, strengthening bone and muscle, adjusts many arteries and veins, and broken Disorder ties stagnated blood, supports fresh blood, puts on flesh, serious epistaxis, spits blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, and scrofula wart is gone to live in the household of one's in-laws on getting married, skin ulcer scabies, and evacuation of pus repercussive blood.

Semen Persicae (parched): the parched medicinal material being Semen Persicae.Semen Persicae: be the dry mature seed of rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunus davidiana (Carr.) Franch..Nature and flavor: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Effect: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.For amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.Record in " herbal classic ": main blood stasis, blood closes lump in the abdomen, pathogen, kills small worm." not Lu ": only cough with dyspnea, disappear hardness in the epigastrium, and except soldier hits blood cruelly, broken lump in the abdomen, promotes blood circulation, pain relieving.

Flos Carthami: be the dried floral of feverfew Flos Carthami Carthamus tinctorius L..Nature and flavor: pungent, temperature.GUIXIN, Liver Channel.Effect: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache." detailed outline ": invigorate blood circulation, moisturizes, pain relieving, loose swollen, stimulates the menstrual flow.

Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor: sweet, acrid, warm.Return liver, the heart, spleen channel.Effect: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.Record in " Japan hanako materia medica ": control a wind cutting, all blood, mend all labor, broken stagnant blood, supports fresh blood and main Disorder addiction.

Rhizoma Phragmitis: be the fresh or dry rhizome of grass phragmites communis Phragmites communis Trin..Nature and flavor: sweet, cold.Attach to the lung and stomach meridians.Effect: clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.For calentura excessive thirst, gastric heat is vomitted the sound of vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.Record in " not Lu ": main exopathogenic heat of quenching one's thirst, only normal urination.

Radix Platycodonis: be Campanulaceae Radix Platycodonis Platycodon grandiflorum(Jacq.) dry root of A.DC..Nature and flavor: bitter, pungent are flat.Return lung meridian.Effect: lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.Record in " not Lu ": sharp the five internal organs the intestines and stomach, gas of enriching blood, except cold and heat, migratory arthralgia, warming middle-JIAO rapid digestion of food, treats laryngopharynx pain.

Flos Chrysanthemi: be the dry capitulum of feverfew chrysanthemum Chrysanthemum morifolium Ramat..Nature and flavor: sweet, bitter, are slightly cold.Return lung, Liver Channel.Function cures mainly: loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.Record in " herbal classic ": main all dizziness due to wind, to swell and ache, order for de-, lacrimation, the dead flesh of skin, aversion to wind arthralgia chiefly caused by damp pathogen, sharp vim and vigour.

Exocarpium Citri Rubrum: be the dry outside rind of rutaceae Huazhou Fructus Citri tangerinae Citrus grandis Osbeck var. tomentosa Hort. or Fructus Citri tangerinae Citrus reticulata Blanco and variety thereof.Nature and flavor: pungent, bitter, temperature.Return lung, spleen channel.Effect: cold expelling, dampness, promoting the circulation of QI, expectorant.For cough due to wind and cold, itching of the throat abundant expectoration, food stagnation is got sick from drinking too much wine, and vomiting and nausea painful abdominal mass is vexed.

Semen Coicis: be the dry mature kernal of grass Semen Coicis Coix lacryma-jobi L. var. ma-yuen (Roman.) Stapf.Nature and flavor: sweet, light, cool.Return spleen, stomach, lung meridian.Effect: spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, row is dense in heat clearing away.For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.Record in " detailed outline ": invigorating spleen and reinforcing stomach, tonifying the lung heat clearing away, removes wind prevailing over dampness.To cook a meal food, control cold air; Decoct drink, diuresis pyretic stranguria.

Semen Lepidii (Semen Descurainiae): be the dry mature seed of crucifer Lepidium sativum L. Lepidium apetalum Willd. or descurainia sophia (l.) webb ex prantl Descurainia sophia (L.) Webb ex prantl.Nature and flavor: pungent, bitter, Great Cold.Return lung, urinary bladder channel.Effect: eliminating pathogen from the lung for relieving asthma, line water detumescence.Stop up lung for sputum, dyspnea and cough with excessive sputum, fullness and distention in the chest and hypochondrium, must not put down sleeping, and ascites pleural fluid swells, dysuria; Pulmonary heart disease edema.Record in " herbal classic ": main lump in the abdomen stagnation of QI, diet cold and heat, broken hard by heresy, tonneau water channel.

Fructus Jujubae: be the dry mature fruit of Rhamnaceae jujube Fructus Jujubae Ziziphus jujuba Mill. var. inermis (Bunge) Rehd..Nature and flavor: sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.Record in " not Lu ": invigorating the spleen and replenishing QI, powerful, except unhappy, outstanding under treating the heart, the out-of-the-way Bleach of intestinal.

Rhizoma Imperatae: be the dry rhizome of grass Herba Imperatae Imperata cylindrica Beauv. var. major (Nees) C. E. Hubb..Nature and flavor: sweet, cold.Return lung, stomach, urinary bladder channel.

Effect: cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema.

Radix Puerariae: be the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi or Radix Puerariae rattan Pueraria thomsonii Benth..Nature and flavor: sweet, pungent, cool.Return spleen, stomach warp.Effect: thirsty, quenches one's thirst, measles without adequate eruption, and hematodiarrhoea, has loose bowels; Hypertension neck pain.Record in " herbal classic ": master quenches one's thirst, and body is too warm, vomiting, all numbness, play cloudy gas, separate all poison.

Rhizoma Polygonati: be the dry rhizome of liliaceous plant P. kingianum Polygonatum kingianum Coll.et Hemsl., Rhizoma Polygonati Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua Polygonatum cyrtonema Hua.Nature and flavor: sweet are flat.Return spleen, lung, kidney channel.Effect: boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.Record in " Bencao Congxin ": put down and fill blood and moisten.

Semen Armeniacae Amarum (parched): be the processed product of the dry mature seed of rosaceous plant Prunus armeniaca L.var.ansu Maxim. (bitter Fructus Pruni) Prunus armeniaca L. var. ansu Maxim., Siberia Fructus Pruni (Prunus armeniaca L.var.ansu Maxim.) Prunus sibirica L., prunus mandshuricaKoehne Prunus mandshurica (Maxim.) Koehne or Fructus Pruni Prunus armeniaca L..Nature and flavor: bitter, tepor; Slightly poisonous.Return lung, large intestine channel.Effect: sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.For cough and asthma, fullness in the chest abundant expectoration, blood deficiency Tianjin is withered, dryness of the intestine constipation.

Flos Farfarae: be the dry flower of feverfew coltsfoot Tussilago farfara L..Nature and flavor: pungent, micro-hardship, temperature.Return lung meridian.Effect: nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm.Cough for new chronic cough, dyspnea and cough with excessive sputum, chronic cough hemoptysis.Record in " property of medicine opinion ": the main treatment lung qi heart is urged, anxious hot weary labor, cough repeatedly without cease, tears saliva is sticky, controls consumptive lung disease lung abscess vomiting pus.

Bulbus Lilii: be the dry meat scale leaf of liliaceous plant tiger lily Lilium lancifolium Thunb., Bulbus Lilii Lilium brownii F.E.Brown var. viridulum Baker or Lilium tenuifolium Lilium pumilum DC..Nature and flavor: sweet, cold.GUIXIN, lung meridian.Effect: nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.Record in " Japan hanako materia medica ": feel at ease, determine gallbladder, beneficial will, support the five internal organs.Control insane heresy to weep, madly to cry, palpitation with fear, kills diseases due to noxious agents produced by various parasites gas, and Xie acute mastitis, carbuncle on the back and all skin ulcers are swollen, and the mad fortune of blood after managing property.

Radix Glehniae: be the dry root of samphire glehnia littoralis Glehnia littoralis Fr. Schmidt ex Miq..Nature and flavor: sweet, micro-hardship, is slightly cold.Attach to the lung and stomach meridians.Effect: nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.For lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound is thirsty.

Radix Ophiopogonis: be the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf) Ophiopogon japonicus (Thunb.) Ker-Gawl..Nature and flavor: sweet, micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.Function cures mainly: YIN nourishing and the production of body fluid promoting, and lung moistening clears away heart-fire.For dryness of the lung dry cough.Chronic consumptive disease is coughed, and Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.

Radix Clematidis: be the dry root and rhizome of ranunculaceae plant Radix Clematidis Clematis chinensis Osbeck, Clematis hexapetala (mountain knotweed) Clematis hexapetala Pall. or northeast clematis (black common vetch) Clematis manshurica Rupr..Nature and flavor: pungent, salty, temperature.Return urinary bladder channel.Effect: expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.For rheumatic arthralgia, numb limbs and tense tendons, the contracture of muscle arteries and veins, joint stuffiness, bone is choked with sobs larynx.Record in Tang Materia Medica: waist, kidney, foot knee joint, gather, all cold diseases of enteral, be not recovered for many years, the effect of clothes.

Radix Glycyrrhizae: be the dry root of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..Nature and flavor: sweet are flat.GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Record in " illustrated handbook planted by middle traditional Chinese medicines ": control peptic ulcer and jaundice.

Side's solution of the present invention is: Radix Astragali invigorating QI to consolidate the body surface resistance, diuresis poison holding in side, Radix Rhodiolae clearing away lung-heat to relieve cough, Radix Codonopsis invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, Radix Platycodonis lung qi dispersing sore-throat relieving, evacuation of pus of eliminating the phlegm, the expectorant of Exocarpium Citri Rubrum promoting the circulation of QI, Semen Lepidii (Semen Descurainiae) eliminating pathogen from the lung for relieving asthma, line water detumescence, Rhizoma Imperatae clearing heat for detumescence, Semen Armeniacae Amarum (parched) relieving cough and asthma, Flos Farfarae nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm, Bulbus Lilii nourishing YIN and moistening the lung, above ten taste medicines are as monarch drug in side, all return lung meridian, there is the effect of lung qi dispersing sore-throat relieving, circulation of qi promoting cough-relieving.Chinese medicine is thought, lung is the canopy of the five internal organs, and its position is the highest, outer conjunction fur, lung being a delicate viscus, not resistance to cold and heat, is again respectful clearly dirty, does not allow foreign body.Lung governing qi, department breathes, diseases caused by exogenous pathogenic factor ailment said due to cold or exposure and cause primary disease.So lung qi dispersing sore-throat relieving, circulation of qi promoting cough-relieving are the bases for the treatment of pulmonary alveolar proteinosis, above ten taste medicines are monarch drug, first fundamentally lung qi dispersing sore-throat relieving, circulation of qi promoting cough-relieving, make disease obtain basic control.Flos Carthami, Radix Salviae Miltiorrhizae promoting blood circulation to restore menstrual flow, Rhizoma Chuanxiong blood-activating and qi-promoting, Semen Persicae (parched) blood circulation promoting and blood stasis dispelling, Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving, Rhizoma Phragmitis clearing away heat and promoting production of body fluid, preventing or arresting vomiting diuresis, the heat clearing away of chrysanthemum powder forimproving wind, suppressing the hyperactive liver improving eyesight, Radix Ophiopogonis YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, Radix Clematidis expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, ministerial drug in the above nine taste medicine sides of being, returns Liver Channel.Liver rises lung and falls the important step that coordination is whole body QI movement being in harmonious way, and the common meridians of liver lung are connected simultaneously.Above nine taste medicines, as ministerial drug, assist effect of monarch drug lung qi dispersing sore-throat relieving, circulation of qi promoting cough-relieving on the one hand; There is as ministerial drug effect of promoting blood flow to regulate menstruation, heat clearing away suppressing the hyperactive liver on the other hand.Semen Coicis spleen invigorating eliminating dampness by diuresis, row is dense in heat clearing away, Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, Radix Puerariae is quenched one's thirst removing toxic substances, Rhizoma Polygonati boosting qi and nourishing yin, spleen invigorating lung moistening, Radix Glehniae yin and clearing lung-heat, reinforcing stomach reg fluid, above five kinds of Chinese medicine returns spleen, stomach warp, spleen rise stomach fall be ascending or descending movement of vital Qi come in and go out hinge, the catharsis of liver directly affects being received of the transporting stomach function regulating of spleen, as adjuvant drug, the inducement of pulmonary alveolar proteinosis is caused from pathology treatment, the lung qi dispersing sore-throat relieving of the monarch and his subjects two medicine can be promoted as adjuvant drug, effect of circulation of qi promoting cough-relieving, body promoting blood flow to regulate menstruation can be promoted by using corrigent the monarch and his subjects two medicine again, the effect of heat clearing away suppressing the hyperactive liver.Radix Glycyrrhizae makes medicine as in side, and have the effect of coordinating the actions of various ingredients in a prescription, mediation flavour of a drug, all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, has effect of lung qi dispersing sore-throat relieving, circulation of qi promoting cough-relieving, promoting blood flow to regulate menstruation, heat clearing away suppressing the hyperactive liver, effectively can treat pulmonary alveolar proteinosis.

Another important feature of the present invention is that this Chinese medicine preparation contains abundant nutritional labeling, be rich in aminoacid and have more than 17 kinds, wherein essential amino acid has threonine, valine, methionine, isoleucine, leucine, lysine and phenylalanine, trace element containing needed by human has ferrum, chromium, copper, boron, manganese, strontium and zinc, several human body macroelement of another calcic, potassium, magnesium, phosphorus.Above nutritional labeling is all needed by human material, effectively can strengthen body immunity.

Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Astragali 28-32 part, Radix Rhodiolae 16-20 part, Radix Codonopsis 13-17 part, Radix Salviae Miltiorrhizae 18-22 part, Rhizoma Chuanxiong 10-14 part, Semen Persicae (parched) 8-12 part, Flos Carthami 7-11 part, Radix Angelicae Sinensis 16-20 part, Rhizoma Phragmitis 18-22 part, Radix Platycodonis 16-22 part, Flos Chrysanthemi 7-11 part, Exocarpium Citri Rubrum 10-14 part, Semen Coicis 18-22 part, Semen Lepidii (Semen Descurainiae) 7-11 part, Fructus Jujubae 10-14 part, Rhizoma Imperatae 18-22 part, Radix Puerariae 10-14 part, Rhizoma Polygonati 13-17 part, Semen Armeniacae Amarum (parched) 7-11 part, Flos Farfarae 10-14 part, Bulbus Lilii 10-14 part, Radix Glehniae 13-17 part, Radix Ophiopogonis 10-14 part, Radix Clematidis 16-20 part, Radix Glycyrrhizae 4-8 part.

Wherein be preferably: the Radix Astragali 30 parts, Radix Rhodiolae 18 parts, Radix Codonopsis 15 parts, Radix Salviae Miltiorrhizae 20 parts, Rhizoma Chuanxiong 12 parts, Semen Persicae (parched) 10 parts, 9 parts, Flos Carthami, Radix Angelicae Sinensis 18 parts, Rhizoma Phragmitis 20 parts, Radix Platycodonis 18 parts, Flos Chrysanthemi 9 parts, Exocarpium Citri Rubrum 12 parts, Semen Coicis 20 parts, Semen Lepidii (Semen Descurainiae) 9 parts, 12 parts, Fructus Jujubae, Rhizoma Imperatae 20 parts, Radix Puerariae 12 parts, Rhizoma Polygonati 15 parts, Semen Armeniacae Amarum (parched) 9 parts, Flos Farfarae 12 parts, Bulbus Lilii 12 parts, Radix Glehniae 15 parts, Radix Ophiopogonis 12 parts, Radix Clematidis 18 parts, Radix Glycyrrhizae 6 parts.

A kind of preparation method of the Chinese medicine preparation for pulmonary alveolar proteinosis is as follows:

Step one: by weight of the present invention, gets Semen Persicae (parched), Semen Armeniacae Amarum (parched), pulverizes, and crosses 200 mesh sieves, for subsequent use;

Step 2: by weight of the present invention, gets Radix Glehniae and puts into container, adds the water of 3 times of volumes, and intense fire infusion is after 40-50 minute, and lard speech with literary allusions fiery infusion 10-20 minute, filter liquor, three times repeatedly, and merging filtrate is for subsequent use;

Step 3: by weight proportion of the present invention, get the Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Rhizoma Phragmitis, Radix Platycodonis, Rhizoma Imperatae, Radix Puerariae, Rhizoma Polygonati, Radix Ophiopogonis, clematis chinensis medicinal materials be placed in marmite, add the water of 8 times of volumes, intense fire infusion is after 20-30 minute, add Radix Rhodiolae, Rhizoma Chuanxiong, Flos Carthami, Radix Angelicae Sinensis, Flos Chrysanthemi, Exocarpium Citri Rubrum, Fructus Jujubae, Flos Farfarae, Bulbus Lilii, Radix Glycyrrhizae and the Semen Coicis tied with bundle respectively, Semen Lepidii (Semen Descurainiae), intense fire infusion 10-20 minute, fiery infusion of larding speech with literary allusions obtains filtrate in 30 ~ 40 minutes, infusion merges gained filtrate three times repeatedly, for subsequent use;

Step 4: step one gained powder of step 2, three gained filtrates being taken after mixing it with water while hot, stirs evenly, both the decoction for the treatment of pulmonary alveolar proteinosis of the present invention.

Using method of the present invention: get decoction, takes in one hour after meal, every day three times.

Medicine of the present invention has the effect of lung qi dispersing sore-throat relieving, circulation of qi promoting cough-relieving, promoting blood flow to regulate menstruation, heat clearing away suppressing the hyperactive liver, and good analgesic effect, cheap, have no side effect, easy to use, the mode that this Chinese medicine preparation adopts is treated and can be reduced the injury of Western medicine to patient body, alleviates the slight illness of patient.

Detailed description of the invention

Embodiment one: the Radix Astragali 30 parts, Radix Rhodiolae 18 parts, Radix Codonopsis 15 parts, Radix Salviae Miltiorrhizae 20 parts, Rhizoma Chuanxiong 12 parts, Semen Persicae (parched) 10 parts, 9 parts, Flos Carthami, Radix Angelicae Sinensis 18 parts, Rhizoma Phragmitis 20 parts, Radix Platycodonis 18 parts, Flos Chrysanthemi 9 parts, Exocarpium Citri Rubrum 12 parts, Semen Coicis 20 parts, Semen Lepidii (Semen Descurainiae) 9 parts, 12 parts, Fructus Jujubae, Rhizoma Imperatae 20 parts, Radix Puerariae 12 parts, Rhizoma Polygonati 15 parts, Semen Armeniacae Amarum (parched) 9 parts, Flos Farfarae 12 parts, Bulbus Lilii 12 parts, Radix Glehniae 15 parts, Radix Ophiopogonis 12 parts, Radix Clematidis 18 parts, Radix Glycyrrhizae 6 parts.

Embodiment two: the Radix Astragali 31 parts, Radix Rhodiolae 17 parts, Radix Codonopsis 16 parts, Radix Salviae Miltiorrhizae 21 parts, Rhizoma Chuanxiong 11 parts, Semen Persicae (parched) 9 parts, 8 parts, Flos Carthami, Radix Angelicae Sinensis 17 parts, Rhizoma Phragmitis 21 parts, Radix Platycodonis 17 parts, Flos Chrysanthemi 9 parts, Exocarpium Citri Rubrum 11 parts, Semen Coicis 20 parts, Semen Lepidii (Semen Descurainiae) 9 parts, 12 parts, Fructus Jujubae, Rhizoma Imperatae 21 parts, Radix Puerariae 11 parts, Rhizoma Polygonati 15 parts, Semen Armeniacae Amarum (parched) 9 parts, Flos Farfarae 11 parts, Bulbus Lilii 13 parts, Radix Glehniae 14 parts, Radix Ophiopogonis 11 parts, Radix Clematidis 17 parts, Radix Glycyrrhizae 9 parts.

Embodiment three: the Radix Astragali 32 parts, Radix Rhodiolae 17 parts, Radix Codonopsis 16 parts, Radix Salviae Miltiorrhizae 21 parts, Rhizoma Chuanxiong 12 parts, Semen Persicae (parched) 10 parts, 8 parts, Flos Carthami, Radix Angelicae Sinensis 18 parts, Rhizoma Phragmitis 20 parts, Radix Platycodonis 17 parts, Flos Chrysanthemi 9 parts, Exocarpium Citri Rubrum 13 parts, Semen Coicis 21 parts, Semen Lepidii (Semen Descurainiae) 9 parts, 13 parts, Fructus Jujubae, Rhizoma Imperatae 20 parts, Radix Puerariae 13 parts, Rhizoma Polygonati 15 parts, Semen Armeniacae Amarum (parched) 9 parts, Flos Farfarae 12 parts, Bulbus Lilii 12 parts, Radix Glehniae 14 parts, Radix Ophiopogonis 13 parts, Radix Clematidis 17 parts, Radix Glycyrrhizae 8 parts.

Here is the clinical statistics data that patient uses medicine of the present invention:

One, diagnostic criteria

1, clinical manifestation: be tachypnea after activity, occasionally have cough, symptom Progressive symmetric erythrokeratodermia increases the weight of, without infecting and hemopathic foundation;

2, chest x-ray: diffusivity lesser tubercle shadow, patch shape shadow or large stretch of consolidation shadow can be shown as, HRCT visible " pattern " or the characteristic of " paving stone sample " change;

3, branchofiberoscope biopsy: pathological examination shows in alveolar space the coarse granule shape material being full of the PAS positive, the visible a large amount of unbodied fragment of bronchoalveolar lavage fluid, the macrophage of normal companion PAS stained positive.

Two, Therapeutic Method:

1, observation group is according to Medications Example one of the present invention, and weighting raw materials, by the treatment of invention implementation method, is got decoction, taken in one hour after meal, every day three times.It within 7 days, is a course for the treatment of.

2, matched group adopts the oral potassium iodide treatment of conventional western medicine, within 7 days, is a course for the treatment of.

Three, efficacy assessment standard:

1, cure: above-mentioned experimental check is all normal, normal pulmonary function.

2, take a turn for the better: have particulate material in alveolation chamber once in a while, pulmonary function is normal.

3, invalid: above-mentioned experimental check is all not improved or instead adds severe one.

Model case and curative effect:

Case one, patient Wang, female, 36 years old, people from Qingdao City, came here and goes to a doctor on January 20th, 2010.Result is as follows after diagnosing: tachypnea after movable, and occasionally have cough, chest x-ray is shown as diffusivity lesser tubercle shadow, and pathological examination shows in alveolar space the coarse granule shape material being full of the PAS positive, is diagnosed as pulmonary alveolar proteinosis.Adopt made preparation in the embodiment of the present invention one, and selected preparation method, after two courses for the treatment of of treatment, effect is very good, and pulmonary function recovers completely or substantially, and Effect of follow-up visit by telephone does not recur half a year.

Case two, patient Lee, man, 42 years old, people from Linyi, Shandong.Come here on May 14th, 2010 to go to a doctor, symptom is as follows after diagnosing: tachypnea after movable, symptom Progressive symmetric erythrokeratodermia increases the weight of, chest x-ray is shown as patch shape shadow, pathological examination shows in alveolar space the coarse granule shape material being full of the PAS positive, the visible a large amount of unbodied fragment of bronchoalveolar lavage fluid, is diagnosed as pulmonary alveolar proteinosis.Adopt made preparation in the embodiment of the present invention one, and selected preparation method, after two courses for the treatment of of treatment, effect is very good, and pulmonary function recovers completely, and Effect of follow-up visit by telephone does not recur half a year.

Claims (4)

1. the Chinese medicine preparation for pulmonary alveolar proteinosis, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Radix Astragali 28-32 part, Radix Rhodiolae 16-20 part, Radix Codonopsis 13-17 part, Radix Salviae Miltiorrhizae 18-22 part, Rhizoma Chuanxiong 10-14 part, Semen Persicae (parched) 8-12 part, Flos Carthami 7-11 part, Radix Angelicae Sinensis 16-20 part, Rhizoma Phragmitis 18-22 part, Radix Platycodonis 16-22 part, Flos Chrysanthemi 7-11 part, Exocarpium Citri Rubrum 10-14 part, Semen Coicis 18-22 part, Semen Lepidii (Semen Descurainiae) 7-11 part, Fructus Jujubae 10-14 part, Rhizoma Imperatae 18-22 part, Radix Puerariae 10-14 part, Rhizoma Polygonati 13-17 part, Semen Armeniacae Amarum (parched) 7-11 part, Flos Farfarae 10-14 part, Bulbus Lilii 10-14 part, Radix Glehniae 13-17 part, Radix Ophiopogonis 10-14 part, Radix Clematidis 16-20 part, Radix Glycyrrhizae 4-8 part.

2. the Chinese medicine preparation for pulmonary alveolar proteinosis according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: the Radix Astragali 30 parts, Radix Rhodiolae 18 parts, Radix Codonopsis 15 parts, Radix Salviae Miltiorrhizae 20 parts, Rhizoma Chuanxiong 12 parts, Semen Persicae (parched) 10 parts, 9 parts, Flos Carthami, Radix Angelicae Sinensis 18 parts, Rhizoma Phragmitis 20 parts, Radix Platycodonis 18 parts, Flos Chrysanthemi 9 parts, Exocarpium Citri Rubrum 12 parts, Semen Coicis 20 parts, Semen Lepidii (Semen Descurainiae) 9 parts, 12 parts, Fructus Jujubae, Rhizoma Imperatae 20 parts, Radix Puerariae 12 parts, Rhizoma Polygonati 15 parts, Semen Armeniacae Amarum (parched) 9 parts, Flos Farfarae 12 parts, Bulbus Lilii 12 parts, Radix Glehniae 15 parts, Radix Ophiopogonis 12 parts, Radix Clematidis 18 parts, Radix Glycyrrhizae 6 parts.

3. the Chinese medicine preparation for pulmonary alveolar proteinosis according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is decoction.

4. for a preparation method for the Chinese medicine preparation of pulmonary alveolar proteinosis, it is characterized in that, preparation method is as follows: step one: by weight of the present invention, gets Semen Persicae (parched), Semen Armeniacae Amarum (parched), pulverizes, and crosses 200 mesh sieves, for subsequent use; Step 2: by weight of the present invention, gets Radix Glehniae and puts into container, adds the water of 3 times of volumes, and intense fire infusion is after 40-50 minute, and lard speech with literary allusions fiery infusion 10-20 minute, filter liquor, three times repeatedly, and merging filtrate is for subsequent use; Step 3: by weight proportion of the present invention; get the Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Rhizoma Phragmitis, Radix Platycodonis, Rhizoma Imperatae, Radix Puerariae, Rhizoma Polygonati, Radix Ophiopogonis, clematis chinensis medicinal materials be placed in marmite; add the water of 8 times of volumes; intense fire infusion is after 20-30 minute; add Radix Rhodiolae, Rhizoma Chuanxiong, Flos Carthami, Radix Angelicae Sinensis, Flos Chrysanthemi, Exocarpium Citri Rubrum, Fructus Jujubae, Flos Farfarae, Bulbus Lilii, Radix Glycyrrhizae and the Semen Coicis tied with bundle respectively, Semen Lepidii (Semen Descurainiae); intense fire infusion 10-20 minute; fiery infusion of larding speech with literary allusions obtains filtrate in 30 ~ 40 minutes; infusion merges gained filtrate three times repeatedly, for subsequent use; Step 4: step one gained powder of step 2, three gained filtrates being taken after mixing it with water while hot, stirs evenly, both the decoction for the treatment of pulmonary alveolar proteinosis of the present invention.