CN105797092B - Yiyuan anti-cold mixture - Google Patents

Abstract

A Yiyuan anti-cold mixture relates to a pharmaceutical composition for treating common cold. In particular to a Chinese patent medicine which is prepared by taking plant Chinese herbal medicines as raw materials and is mainly used for treating common cold and a preparation method of the medicine. The technical problem to be solved by the invention is as follows: 1. promoting the cold patients with weak body to shorten the treatment period and the recovery period after illness; 2. the probability of primary disease deterioration or complication caused by cold of the patient with chronic disease is reduced; 3. the probability of the cold patient catching a cold again is reduced. The key points of the technical scheme for solving the problems are as follows: 1. the sweat method is used for expelling pathogenic factors from muscles and skin, relieving exterior syndrome, harmonizing ying and wei and eliminating pathogenic factors; 2. regulating and improving physiological functions of viscera by using a 'tonifying method'; 3. the "harmony method" is used to transform the unbalanced qi and blood, viscera and cold and heat of the body into a balanced state; the effects of quickly improving immunity and dispelling cold, gradually dissipating and transmitting the new and long-term wind-cold, and self-healing all the symptoms are achieved. The main application is as follows: can be used for treating common cold.

Description

Yiyuan anti-cold mixture

Technical Field

The medicine relates to a medicine composition for treating common cold. In particular to a Chinese patent medicine which is prepared by taking plant Chinese herbal medicines as raw materials and is mainly used for treating common cold and a preparation method of the medicine.

Background

General description of common Cold

Common cold is called upper respiratory tract infection, referred to as upper respiratory tract infection, and is a general term for acute inflammation of nasal cavity, pharynx or larynx. The disease can be caused all the year round, the incidence rate in winter and spring is high, the disease course of the weak and the people with chronic diseases suffering from cold is long, the primary disease is worsened or the complication is caused by the cold, and the probability of repeated cold is also high.

Common method and defect for treating common cold by using existing medical technology

Modern medicine mainly adopts antipyretic analgesic and antihistamine drugs for symptomatic treatment, and uses antiviral drugs or antibiotics for etiological treatment, so as to achieve the purposes of improving symptoms and shortening course of disease. If the antibiotics or antiviral drugs are continuously used for a long time, the immune function of the human body is reduced, the body is weak and patients suffering from chronic diseases are often suffered from the side effects of prolonging the treatment period or causing the deterioration of the primary disease and possible complications. In addition, the two types of drugs have the problems of drug resistance, drug-induced diseases and adverse drug reactions.

The traditional Chinese medicine classifies the common cold into the category of exterior syndromes, and also classifies the exterior syndromes into exterior cold syndromes, exterior heat syndromes and exterior syndromes caused by the feeling of external evil of deficient people. The Chinese patent medicine for treating the common cold mainly comprises the traditional Chinese medicines for dispelling wind cold and relieving exterior syndrome, and achieves the purposes of improving symptoms and shortening the course of disease by dispersing wind cold or dispelling wind and heat. For the cold patients with weak body, the medicines for strengthening body resistance and relieving exterior syndrome are adopted for treatment. For example: shensu Wan is prepared from 11 Chinese medicinal materials of pilose Asiabell root, perilla leaf, kudzu vine root, etc. and has the functions of benefiting vital energy, relieving exterior syndrome, dispelling wind and cold, eliminating phlegm and arresting cough. It is used for treating common cold caused by asthenia and wind cold. The following steps are repeated: the ginseng toxin-vanquishing capsule is prepared by combining 12 traditional Chinese medicines of ginseng, radix angelicae pubescentis, notopterygium root, ligusticum wallichii and the like, and has the effects of tonifying qi, relieving exterior syndrome, dispelling cold and eliminating dampness. It is clinically used for treating common cold caused by qi deficiency and exogenous wind-cold-dampness. The mixture for resisting cold is prepared by combining eleven traditional Chinese medicines such as astragalus, figwort root, dwarf lilyturf tuber, honeysuckle, isatis root and the like, has the effects of tonifying qi and yin, and relieving exterior syndrome and eliminating evil, and is suitable for treating cold caused by weakness and exogenous wind-cold. Such herbs that can strengthen the body resistance and relieve exterior syndrome all focus on improving the symptoms of deficiency of the body resistance and cold, but do not improve the immunity of human body. In the pathology of a weak common cold patient, the cold course is long due to the existence of pathological factors with low immune function, and the probability of repeated cold is high because the primary disease is worsened or complications are possibly caused by cold. Even after a healthy person suffers from a cold, the immune function is reduced to various degrees. The existing Chinese patent medicine for treating the common cold does not have toxic or side effect like western medicines, but lacks corresponding components and strength in the aspects of supplementing primordial qi lost by patients, recovering the immunity of human bodies, focusing on treatment of root causes and the like.

The common cold has caused serious harm to human health

Because the common cold is a self-limiting disease and needs to be eliminated by means of human immunity, the medicine market lacks medicines which can recover human immunity and treat the common cold from the source, and the common cold causes serious harm to individuals and society at present. According to the statistical report of the authority,the average number of the adults suffering from the common cold is 2-3 times per year, the average number of the children suffering from the common cold is 5-7 times per year, and 10% -15% of the children suffer from the common cold 12 times per year^[1]. People with basic diseases can obviously increase the prevalence rate of common cold, for example, people with diabetes have the prevalence rate of cold 3 times that of healthy people, people with respiratory diseases 13 times that of healthy people, and people with circulatory basic diseases 3.5 times that of healthy people^[2]. The common cold can cause a great economic burden, and the American data show that 30 percent of miscarriage and 40 percent of mislabor are caused by the common cold, the common cold causes 23 hundred million days of miscarriage and 25 hundred million days of mislabor each year, the number of people who see the common cold is 27 hundred million people each year, the cost of over-the-counter medicines for relieving cold symptoms such as cough and the like is nearly 20 hundred million dollars each year, and the cost of antibacterial medicines is 22.7 hundred million dollars. In addition, the treatment of complications and the aggravation of primary diseases significantly increase medical costs and burden of diseases^[3].. The common cold is not common, and the domestic and foreign data show that the common cold not only can cause serious social and economic burden, but also can generate serious complications and even threaten the life of patients to die^[4]。

The purpose of the invention and the exploration

Because the common cold is eliminated mainly by means of the immunity of a human body, the inventor intentionally develops a traditional Chinese medicine preparation which can treat the common cold mainly by quickly improving the immunity. Before 1992, the inventor used a method of strengthening body resistance and relieving exterior syndrome, and added medicaments for replenishing qi, blood and yin into cassia twig decoction and the like, and then the medicaments for replenishing qi, blood and yin or tonifying yang were added according to the type of the body resistance deficiency, and the dosage of the medicaments for tonifying qi, nourishing blood and yin or tonifying yang is increased or the medicaments are added to carry out the prescription respectively to treat the exterior deficiency syndrome of exogenous wind-cold, and the medicaments are prepared into 6 preparations respectively and are supplied to cold patients with corresponding 6 types of symptoms (qi deficiency, blood deficiency, yin deficiency, yang deficiency, deficiency of both qi and yin and yang deficiency). Although the prescription has accurate dialectical results, the prescription accords with the prescription principle of traditional Chinese medicine and has certain treatment effect, because qi, blood, yin and yang are not only products of physiological functions of viscera, but also elements for regulating and enhancing the physiological functions of viscera. There are two disadvantages, however: first, the strength of improving immune function is still insufficient. Secondly, 6 preparations are needed to treat 6 syndromes. If the industrial production is carried out for the large-scale consumption market, the investment in the field of pharmacy, packaging, storage, circulation, etc., the investment in equipment investment, production personnel, management personnel, etc. is large. The inventors have searched for 5 years in order to find a method capable of improving the efficacy of treating cold and reducing the kinds of preparations.

The main medical data referred to by the inventor in establishing the key technical scheme

In 1997 in 6 months, the inventor saw the introduction of clinical experience of ' Suanyinli in China J.Pipi.Yi and Yi Xue Ji- ' the pathological mechanism and treatment of cirrhosis '^[5]The inventor introduces the experience of treating liver cirrhosis by using the self-prepared liver-clearing and stasis-removing decoction for the aged to achieve the effects of liver depression, liver heat clearing, liver yin nourishing and meridian warming and dredging, and assisting with spleen-strengthening and kidney-tonifying medicines to promote the recovery of the functions of liver, spleen and kidney. The basic prescription comprises 10g of schisandra chinensis, 10g of dried ginger, 20g of rhizoma anemarrhenae, 10g of cassia twig, 10g of dandelion, 10g of polygala tenuifolia, 10g of scutellaria baicalensis, 8g of liquorice, 35g of radix rehmanniae, 10g of flos caryophyllata, 18 jujubes, 10g of codonopsis pilosula and 10g of pinellia ternate.

The invention relates to a method for promoting the recovery of functions of liver, spleen and kidney by using cassia twig decoction and referring to liver-clearing depression-relieving decoction of Chinese elder herb

The inventor discovers from analyzing the comprehensive pharmacology of the aged liver-clearing and stasis-relieving decoction that the formula can replenish qi, blood, yin and yang, has the effects of regulating, improving and improving the physiological functions of viscera and replenishing primordial qi of a human body, can be exactly used in the prescription of a medicament for treating the weak cold, and can be used as a part for recovering the physiological functions of the viscera, particularly improving the immunity and realize the effects of dispelling wind, relieving the stagnation, tonifying primordial qi and relieving the exterior by adding exterior-releasing medicaments. The formula is combined with the cassia twig decoction to be prepared into a prescription, and the prescription is applied to the clinical treatment of the exterior deficiency syndrome caused by exogenous wind-cold. 10g of cassia twig is used as the original prescription, and has the main functions of warming and dredging channels and collaterals, and transforming qi and promoting water circulation so as to treat ascites due to cirrhosis. The formula changes cassia twig into 20g to strengthen the power of inducing sweat and expelling pathogenic wind and cold, and is taken as a monarch drug; 10 grams of white paeony root is added, and the white paeony root is used together with cassia twig to regulate ying and wei, so that the white paeony root can sweat without damaging yin and can stop sweating without loving evil, and is a ministerial drug; 10g of ginger is added to assist the cassia twig to sweat and release exterior, and also warm the stomach and arrest vomiting; 12 g of astragalus root is added to supplement defensive qi on the surface, and the astragalus root and the defensive qi are used as adjuvant drugs; the main point of the recipe is to eliminate affection of exogenous wind-cold, so 34 g of Sheng Di Huang is used to reduce cold and cool; the original prescription uses 18 Chinese dates (calculated according to the weight of the common size, about 60-80 g), and the dosage is changed to 100 g in order to fully utilize the effects of tonifying spleen and qi, strengthening body resistance and eliminating evil and the convenience of weighing ingredients; the licorice root used in the original prescription is 8g of raw licorice root, which has the main function of clearing heat and removing toxicity to protect the liver, while the prescription needs to coordinate cassia twig to release muscles, assist white peony root to regulate ying, and five Chinese dates to tonify qi and harmonize the drugs, so 15 g of prepared licorice root is used instead. The whole formula comprises: 20g of cassia twig, 10g of white paeony root, 10g of ginger, 12 g of astragalus root, 10g of dried ginger, 34 g of dried rehmannia root, 20g of rhizoma anemarrhenae, 10g of flos caryophyllata, 10g of codonopsis pilosula, 100 g of Chinese date, 10g of Chinese magnoliavine fruit, 10g of polygala root, 15 g of honey-fried licorice root, 10g of prepared pinellia tuber, 10g of baical skullcap root and 10g of dandelion. It can be made into mixture for treating intractable wind-cold exterior deficiency syndrome. The optimal scheme is screened after … … prescriptions are modified for a plurality of times through prescription-clinical trial-reformulation-clinical trial, and clinical curative effect test is repeatedly carried out, and unexpected effects are obtained as a result: the medicine can rapidly improve immunity, shorten treatment period and recovery period of common cold of patients with asthenia and chronic diseases, and especially prevent deterioration or complications due to common cold, and frequent test. It was also found that the probability of the patient again catching a cold could be greatly reduced by follow-up at a later date (see "experimental example" in effect of invention "for details).

Different points of Yiyuan anti-cold mixture and Qinggan Dayu Tang

From the constitution of the prescription, the prescription of the Yiyuan anti-cold mixture is the same as that of the Qinggan Dayu decoction by 12 medicaments, and the prescription of the Yiyuan anti-cold mixture almost comprises all the medicaments in the Qinggan Dayu decoction, except that 8g of liquorice is used in the Qinggan Dayu decoction, and 15 g of honey-fried licorice root is used in the Yiyuan anti-cold mixture. However, the efficacy of Yiyuan anti-cold mixture is totally different from that of Qinggan Dayu Tang. This is because: firstly, in terms of the dosage of the medicine, the dosage of the cassia twig in the mixture for benefiting the primordial qi and resisting the cold is 1 time more than that in the liver-clearing and stasis-removing decoction, so that the cassia twig fully plays the roles of entering and exiting the cardiotonic and transforming liquid, dredging the meridian and sweating, and dispersing wind-cold; secondly, the Yiyuan anti-influenza agent increases the pharmaceutical composition with the function of relieving exterior syndrome: ginger, white peony root and astragalus root. Ginger is pungent and warm in property, and can expel wind and remove cold; radix astragali has effects of invigorating spleen, nourishing lung, strengthening vital qi, and eliminating pathogenic factors; the combination of white peony root and cassia twig can regulate nutrient and defensive qi, and is beneficial to sweating and relieving exterior syndrome. And thirdly, the honey-fried licorice root is used for replacing the raw licorice root in the liver-clearing and depression-relieving decoction. Raw gan Cao is cool and good at clearing heat and removing toxicity to protect liver; while the prepared licorice root, being warm, has the actions of tonifying qi, regulating the middle energizer, relieving spasm and harmonizing the property of herbs. The dosage of the Chinese dates for nourishing nutrition and transforming defense is increased, the dosage of the cold-natured dried rehmannia root is reduced by 1 g compared with the dosage of the liver-clearing and depression-relieving decoction, the effects of the vitality-benefiting and anti-cold mixture for dispelling wind and cold are established by the change of the medicines and the dosages, and the rest medicines become adjuvant medicines and adjuvant medicines for improving the immunity of human bodies to help eliminate pathogenic factors. The changed result is that the liver-clearing and depression-relieving soup is converted into an exterior-resolving agent which is used for dispelling lung cold, assisting lung defense, tonifying primordial qi, strengthening body resistance, promoting lung, spleen and kidney functions to recover, dispelling wind, relieving depression, benefiting primordial qi and relieving exterior syndrome, by taking a method of relieving liver depression, clearing liver heat, nourishing liver yin and dredging collaterals as an auxiliary method and a medicine for assisting spleen in strengthening and invigorating the kidney and promoting liver, spleen and kidney functions to recover so as to treat liver cirrhosis.

Disclosure of the invention

The Chinese patent medicine for treating the common cold, namely the Yiyuan anti-cold mixture, is prepared from the following raw material medicines in parts by weight: 60 g of cassia twig, 30 g of white paeony root, 30 g of ginger, 36 g of astragalus root, 30 g of dried ginger, 102 g of dried rehmannia root, 60 g of rhizoma anemarrhenae, 30 g of flos caryophyllata, 30 g of codonopsis pilosula, 300 g of Chinese date, 30 g of Chinese magnoliavine fruit, 30 g of polygala root, 45 g of honey-fried licorice root, 30 g of prepared pinellia tuber, 30 g of baical skullcap root and 30 g of dandelion.

Functional indication of Yiyuan anti-cold mixture

The functions are as follows: dispel wind, relieve depression, benefit vitality and relieve exterior syndrome.

The main treatment is as follows: exterior deficiency syndrome due to wind-cold. Is suitable for common cold with the following symptoms: aversion to cold, fever, sweating, aversion to wind, headache, or a strong neck, nasal obstruction, nasal discharge, cough, thin and white sputum, restlessness, insomnia, soreness of the limbs, retching or vomiting, thin and white tongue coating, floating, slow or weak pulse.

The technical problem to be solved by the invention and the key points of the technical scheme for solving the problem

The invention aims to solve the technical problems of medical treatment that: promoting the cold patients with weak body to shorten the treatment period and the recovery period after illness; the probability of primary disease deterioration or complication caused by cold of the patient with chronic disease is reduced; the probability of the cold patient catching a cold again is reduced.

The key points of the technical scheme for solving the problem are as follows: the sweat method is used for expelling pathogenic factors from muscles and skin, relieving exterior syndrome, harmonizing ying and wei and expelling pathogenic factors; regulating and improving physiological functions of viscera by using a 'tonifying method'; the "harmony method" is used to transform the unbalanced qi and blood, the unbalanced viscera and the unbalanced cold and heat into a balanced state; by the comprehensive application of the 3 schemes, the primordial qi of the human body is enhanced, the healthy energy (immunity and cold dispelling capability) is improved, the disease transmission is prevented, the medicine for treating the wind-cold for a long time is gradually dissipated, and all the diseases are self-cured.

Treatment method applied by formula of mixture for treating exterior deficiency syndrome due to exogenous wind-cold and benefiting primordial qi and resisting cold, and efficacy and characteristics of each medicament and composition thereof

The formula is originally designed for treating the exopathic wind-cold exterior deficiency syndrome (a syndrome of cold) caused by asthenia of body, but can also be used for exopathic wind-cold exterior deficiency syndrome suffered by common people. The patients with constitutional weakness are most susceptible to exterior deficiency syndrome due to wind-cold. Once the patients suffer from wind-cold and can not be fixed due to deficiency of defensive yang, the skin, skin and skin striae are loose, the patients have aversion to wind and cold, and the pulse is floating and slow or weak; cold retention in the channels and collaterals can lead to headache, neck rigidity, soreness of the limbs, and weakness of the limbs; the lung is communicated with the outside through nose and mouth, is combined with fur, is most easily injured by wind-cold invasion, and has rhinorrhea, nasal obstruction and nasal discharge; or retching or vomiting due to incoordination between stomach qi; or fullness in the chest and epigastrium, poor appetite. The struggle between defensive qi and pathogenic qi will cause fever, which may lead to the skin and striae of the skin and skin, while yin deficiency may not lead to internal defense, so spontaneous sweating occurs. Repeated fever and unhealed sweating, and new and old coldness mixed with the disease cause the deficiency of nutrient and defensive qi, the weakness of original qi, the deficiency of healthy qi and the stagnation of qi activity, so the pathogenic factors of the new and old diseases are not released continuously. For it is suitable for dispelling wind and resolving stagnation, benefiting vitality and relieving exterior syndrome.

In the formula, the cassia twig, pungent and sweet in taste and warm in nature, can expel wind and cold, activate heart-yang, warm the chest and abdomen, warm the spleen and stomach, induce sweating and release muscles to help defense, warm and dredge channels, and support yang and transform qi to nourish yin, so the cassia twig is a monarch drug. The white peony root has the effects of nourishing blood and astringing yin, can strengthen the function of nourishing yin and keeping yin inside, treats the symptom of sweating, is compatible with the cassia twig, has the effects of dispersing and collecting, harmonizing ying and weiqi, and enables sweating without hurting yin and arresting sweating without lingering pathogen, so the white peony root is a ministerial drug. Ginger, rhizoma Zingiberis recens, being pungent and warm in property, can dispel wind and cold, and is good at coordinating with Gui Zhi to induce sweat and release exterior, and to help Gui and Shao to release muscles and ying, and warm stomach and arrest vomiting. Astragalus root is sweet and warm, nourishes lung qi, strengthens defensive qi, can not generate sweat, can stop sweat and can strengthen the force of defending the body; the ginger and the astragalus root are used as adjuvant drugs. If the primordial qi is abundant, the exogenous pathogenic factors will be dominant as the herbs. For the weak people, the original qi is insufficient, the nutrient and defensive qi are weak, the former herbs are not used for dispelling pathogenic factors, the latter ones do not produce pathogenic factors, the latter ones do not shrink with the original qi, so the aversion to cold and fever are lingering. Therefore, multiple targets are needed to dispel cold and improve physiological functions of viscera to supplement deficient primordial qi to promote healthy qi, and drugs with functions of warming meridians and promoting blood circulation, promoting qi circulation and relieving depression and regulating qi activity are added into exterior drugs to help the drugs to gradually dissipate pathogenic qi. Therefore, the pungent and hot property of the dried ginger, which warms the middle and dispels cold, can dispel the deficiency-cold of the zang-fu organs and stop vomiting and diarrhea to recover the yang of the spleen and stomach; it also has effects in warming lung, relieving cough, eliminating phlegm, relieving stuffy nose, and expelling nasal discharge, and can be used for dispelling pathogenic wind and cold. Radix rehmanniae is cold in nature, sweet and bitter in taste, can nourish yin and promote the production of body fluid; the combination of the ginger and the dried ginger not only has no cold and cool disadvantages, but also can promote the generation of blood and promote the secretion of saliva; it also can nourish yin of lung, spleen and kidney, and strengthen yang of lung, spleen and kidney. Flos Caryophylli is warm in nature and pungent in taste, and has effects of warming middle energizer, lowering adverse qi, regulating stomach function, relieving emesis due to deficiency cold, relieving psychroalgia of heart and abdomen, warming kidney, and tonifying yang; rhizoma anemarrhenae is cold, bitter and sweet, has the effects of nourishing yin and moistening dryness, and can purge kidney fire without root to treat bone steaming with sweat; to prevent consumptive heat, nourish yin of the source, and prevent the warm and dry cassia twig, dried ginger and flos caryophylli from generating strong fire to eat qi, consume blood, damage yin and damage yang; it is combined with flos Caryophylli to strengthen the action of tonifying lung, spleen and kidney. When the lung defense is the fence of defensive qi of the body, the body will eliminate pathogens and strengthen the body. The spleen is acquired, spleen yin and spleen yang are supported, so that qi, blood, nutrition and nutrition are activated, defensive qi is assisted, and lung defense is not disturbed by pathogenic factors. Kidney qi is the root of lung wei, the root of yin and yang of human body, kidney yin and kidney yang being relieved, the nutrition is orderly and the lung wei is in the best period. In the above 4 herbs, two yin and two yang, yin depends on yang to transform nutrient, while yang depends on yin to transform defensive, tonify without stagnation, and disperse without dispersion. The radix codonopsitis and the Chinese date are sweet and warm, and have the effects of strengthening spleen and replenishing qi and are beneficial to expelling pathogenic factors. The Chinese dates can nourish yin, enrich blood, nourish nutrition, transform nutrition and defend, and are used for the assistance of white paeony root and nutrition; it is combined with two gingers, so it is said that "pungent and sweet dispersing is yang". Wu Wei Zi can astringe lung and kidney, astringe sweat and promote fluid production, and is combined with Gui Zhi and gan Jiang to strengthen the body without stagnation. Bai Shao, Sheng Di Huang, Zhi mu and Wu Wei Zi all have the action of astringing all the dispersing herbs and can alleviate the strong nature of Gui Zhi and gan Jiang to remove wind-cold-phlegm-dampness without damaging qi and blood. Polygala tenuifolia is pungent and bitter in taste, slightly warm in nature, and has effects of eliminating phlegm, relieving cough, calming heart and tranquilizing mind. The compatibility of the ginseng, jujube and grass can transform water and fire. Prepared licorice root, radix Glycyrrhizae Praeparata, in combination with cinnamon twig, ramulus Cinnamomi, helps to regulate the nutrient and white peony root, and fructus Jujubae, in the five categories, tonifies qi and has the action of promoting the interior and exterior. The combination of the ginger, the Chinese date and the liquorice can tonify middle-warmer energy, regulate yingfen and weifen and help sweating; the combination of the 9 medicines can improve the physiological functions of viscera, tonify primordial qi, warm and dredge channels, promote qi circulation and relieve depression, and regulate qi activity, so as to benefit deficiency and insufficiency; moreover, it can protect the zang-fu organs, prevent invasion of pathogenic factors into the interior, and reject life-changing syndrome, and has the effect of strengthening the body resistance to eliminate pathogenic factors, so it is a method of relieving interior, not all of them are used for tonifying deficiency. The functional relationship between Gui and Shao is for thick, thin hair, which is used as adjuvant drug. Rhizoma Pinelliae Preparada eliminates dampness and phlegm; the scutellaria baicalensis clears heat and dries dampness; the dandelion is used for removing heat toxin and dissipating stagnation of qi, the 3 medicines are combined together to remove redundant damp-heat in the formula, and the dandelion is used as a guiding drug. Prepared licorice root, radix Glycyrrhizae Praeparata coordinates the effects of the other drugs in the recipe, and acts as a guiding drug. The formula comprehensively applies three methods of sweating, tonifying and nourishing. The 'sweating method' and the 'tonifying method' are combined as described above, namely, in the process of applying the 'sweating method' and the 'tonifying method', cold and heat are used together, and a mixture is supplemented and discharged, so that the middle-jiao is supplemented and the middle-jiao is attacked, and the middle-jiao is supplemented; harmonizing yingfen and weifen, harmonizing liver and spleen, and harmonizing intestines and stomach; the method of balancing qi and blood, balancing viscera, and balancing cold and heat can transform unbalanced yin and yang into a balanced state, so that qi activity in vivo returns to its normal ascending and descending, viscera perform their own functions, promote recovery of original qi from various aspects, promote healthy qi, and eliminate pathogenic qi at multiple target points. The whole formula is combined, the aim of relieving exterior syndrome is taken, the methods of sweating, tonifying viscera, benefiting primordial qi, strengthening vital qi, relieving depression qi and balancing yin and yang are comprehensively applied, the recovery of the functions of lung, spleen and kidney is promoted, the immunity of the organism is quickly improved, the new and long-term wind-cold is gradually dissipated, the transmission is not good, all symptoms are quickly cured, the effects of dispelling wind, relieving depression and benefiting primordial qi and relieving exterior syndrome are achieved, and the method for treating both principal and secondary aspect of disease is a method for treating the root cause of disease.

Preparation method of Yiyuan anti-cold mixture

Firstly, weighing 300 g of Chinese dates, storing in another container, adding 0.5kg of water, and soaking for 2 h; weighing the other 15 traditional Chinese medicinal materials according to the weight parts, combining the Chinese dates and the water for soaking the Chinese dates, putting the Chinese medicinal materials in a multifunctional Chinese medicinal extraction tank, adding 5.5Kg of water into the extraction tank, and soaking the Chinese medicaments for 60 min; introducing steam into the tank to heat the medicine, introducing steam into the interlayer when the temperature of the medicine reaches 100 ℃, indirectly heating the medicine, and maintaining the temperature in the tank at about 100 ℃ for 3 hours; filtering the decoction, and storing in another container; adding 3Kg of water into the medicine in the tank again, decocting for 3h in the same way, filtering to obtain decoction, squeezing residues, mixing 2 times of decoctions, standing for precipitation for 24h, filtering, sucking supernatant, concentrating to relative density of 1.15 at 90-95 deg.C, adding 0.6g of sodium benzoate, stirring, and mixing to obtain 600ml of the preparation; filling into cleaned, sterilized and dried hot bottle in micro-boiling state, sealing the bottle mouth immediately when the temperature of the hot bottle is about 80 ℃, cooling and sticking labels.

Process flow diagram

Leaching → purification → concentration → sterilization → split charging

Description of Process and Process flow at point 3

The extraction process aims at enhancing the immunity of human body, and does not mainly release the exterior through sweating, so the oil-water separation method is not adopted and the production process of extracting the volatile oil of the cassia twig and the dried ginger is not adopted.

The time and the frequency of decoction are determined according to the preparation experience of the inventor and the research data of Jia Chun and the like on the production process of the traditional Chinese medicine mixture: decocting for 3 hr each time, and decocting for 2 times. Jia (traditional Chinese medicine)The research report of Chunchun et al on the production process of the Chinese medicinal mixture indicates that: the paste yield is 3.37 percent higher than that of decocting for 2 hours every time of decocting for 3 hours, and is 0.33 percent lower than that of decocting for 4 hours. Therefore, 3 hours of decoction each time is the best decoction time. Decocting for 2 times, and extracting 93.4% of the total decoction obtained by decocting for 3 times. The factors of labor cost, energy consumption, depreciation of equipment and the like are comprehensively considered, so that the decoction is preferably carried out for 2 times.^[6]

The later process of the general production process of the mixture with the sequence of sterilization and subpackaging is mainly to subpackage firstly and then sterilize. The process adopts the steps of sterilizing by boiling in the final concentration stage, adding sodium benzoate, filling in a sterilized hot bottle, and immediately sealing the bottle mouth. Sterilizing and then subpackaging. Sterile plants and strict process regulations can ensure the sterilization effect.

Raw materials for preparing Yiyuan anti-cold mixture

Chinese medicinal materials

The Ramulus Cinnamomi is dried twig of cortex Cinnamomi (Cinnamomum cassia Presl) belonging to family Lauraceae, evergreen arbor. Harvesting in spring and summer, removing leaves, slightly soaking in water, taking out, moistening thoroughly, slicing, air drying, and sieving to remove dandruff. The cassia twig is warm in nature and pungent and sweet in flavor; it enters bladder, heart and lung meridians. In China, Fujian, Taiwan, Hainan, Guangdong, Guangxi, Yunnan and other tropical and subtropical regions are cultivated, most of the Guangxi cultivation is artificial pure forest. Selecting Guangxi variety.

Radix Paeoniae alba is root of Paeonia lactiflora Pall (cultivar) of Ranunculaceae, a perennial herb of dicotyledonous plant. Digging 3-4 years old planted radix Paeoniae, removing rhizome and fibrous root, cleaning, removing coarse skin, boiling in boiling water to soften and moisten, taking out, air drying, removing impurities, slicing, and sun drying. White peony root is slightly cold in nature, slightly bitter and sour in taste; it enters liver and spleen meridians. All over the country. The product produced in Zhejiang is called Hangzhou white peony root, and has the best quality; the person who produces Anhui is called Mao Bai Shao, and the yield is the maximum; the one produced in Sichuan is named Chuan Bai Shao and Zhongjiang Shao, and the yield is also large. Selecting Anhui variety.

The rhizoma Zingiberis recens is fresh rhizome of Zingiber officinale Rosc. Collected in autumn and winter, removed fibrous root and silt, sliced, unprocessed. Warm in nature and pungent in flavor. It enters lung, spleen and stomach meridians. All the places produce. Selecting Anhui variety.

Radix astragali is root of Astragalus membranaceus bge Astragalus membrane aceus (Fisch.) of Leguminosae herbaceous plant. Harvesting before germination in autumn plants withered or in spring of the next year, and harvesting in the middle and last 9 months is good generally. The whole root planted for 2-3 years is carefully dug by a tool, and the black heart can be generated after the growth period is too long, thereby affecting the quality. Avoiding damaging the outer skin and the broken roots, removing soil, cutting off the reed heads when the fresh reed heads are fresh, trimming the fibrous roots, drying to be semi-dry, stacking for 1-2d to regain moisture, spreading and drying repeatedly until the full dry, straightening the roots, bundling into small bundles, and slicing, wherein the quality is better for the people with thick strips, less wrinkles, yellow and white cross sections, enough powder and sweet taste. Radix astragali is slightly warm in nature and sweet in taste; it enters lung, spleen, liver and kidney meridians. The roots of astragalus mongholicus (astragalus membranaceus) which is the inner Mongolia are cultivated all over the country, and the quality is good. The minor part is the root of Astragalus membranaceus. Selecting inner Mongolia varieties.

The Zingiberis rhizoma is dried rhizome of Zingiber officinale Rosc (Zingiber oj-jicinale Rosc) belonging to Zingiberaceae family. Collecting, removing stem and leaf and fibrous root, cleaning, sun drying or low temperature drying, and slicing. Gan Jiang is pungent in flavor and hot in nature. It enters spleen, stomach, heart and lung meridians. Most areas of China are cultivated, and Sichuan and Guizhou are mainly produced. Selecting Sichuan variety.

Radix rehmanniae is root tuber of radix rehmanniae (Rehmannia glutinosa) of Scrophulariaceae family of dicotyledon. Collecting rhizome in autumn, removing rhizoma Phragmitis, stem and leaf, and fibrous root, cleaning soil, slicing radix rehmanniae, and sun drying or oven drying. Sheng Di Huang is cold in nature, sweet and bitter in flavor, entering heart, liver and kidney meridians. Mainly produced in Henan, Liaoning, Hebei, Shandong and Zhejiang, most notably Henan, and the Henan variety is selected.

Flos Caryophylli is the bud of evergreen arbor plant (Eugenia caryophyllata Thunb) of Myrtaceae. Removing pedicel after picking, and drying in the sun. Flos Caryophylli is warm in nature and pungent in flavor. Enter lung, spleen, stomach and kidney meridians. Flos Caryophylli is one of the traditional imported south medicine in China, and is native to Morus Luagua in Indonesia and Morus harbourne in tanzania. At present, the betel nut, the Sumen wax, the Java are produced in Indonesia and countries and regions such as Malaysia, Vietnam and oceania. In 50 s of China, introduction was successful, and the Hainan province and the fields of Leizhou peninsula, Guangdong, Guangxi and the like are cultivated. Selecting Guangxi variety.

Rhizoma anemarrhenae is dried rhizome of Liliaceae rhizoma anemarrhenae (Anemarrhena asphodeloides Bunge) of Liliaceae, perennial herbaceous plant. The rhizoma anemarrhenae is planted in spring and autumn by digging up rhizoma anemarrhenae for 2-3 years, harvesting in autumn, removing stem seedling, fibrous root and silt, and drying in the sun. Or removing the outer skin, drying in the ventilation place, and slicing for use. Rhizoma anemarrhenae is cold in nature, bitter and sweet in taste; it enters lung, stomach and kidney meridians. The main products are Hebei, Shanxi, inner Mongolia, Shanxi and northeast, etc. Selecting Hebei variety.

The radix Codonopsis is dried root of Codonopsis pilosula Nannf.var.modesta (Nannf.) L.T.Shen or Codonopsis tandshen Oliv of root of Codonopsis pilosula (Codonopsis West) belonging to Campanulaceae family and belonging to multiple plants of perennial herbaceous plants such as radix Codonopsis, Suhua radix Codonopsis, and radix Codonopsis Pilosulae. It is named as Tai Dang Shen because it is originally produced in Shanxi Shang Dang basin and is produced in Wutai county as much as it is. Tai Dang Shen is the most excellent quality of wild one and is the treasure of Dang Shen. Collected in autumn, washed and dried in the sun. Dang Shen is neutral in nature, sweet in flavor and slightly sour. It enters spleen and lung meridians. Most of the cultivated plants are produced in Shanxi province. Also produced in northeast, northeast China, Shaanxi, Ningxia, Gansu, Qinghai, Henan, Sichuan, Yunnan, Tibet, etc. Selecting Henan variety.

Fructus Jujubae is dried mature fruit of Ziziphus jujuba Mill. var. inermis (Bunge) Rehd belonging to Ziziphus of Rhamnaceae. The red dates are ripe in 8-9 months, picked, cleaned of impurities and dried in the sun. The Chinese dates are mild in nature and sweet in taste. It enters spleen and stomach meridians. The jujube produced in most regions in China accounts for over 80 percent of the total annual output of jujubes produced in Shandong, Hebei, Shanxi, Shaanxi and Anhui provinces. The famous Chinese date varieties in China include Shanxi Huanghe Tibet date, Wufo date, Shandong date, Sihong date, Fuping date, Zanhuang date, Hami date, Xinzheng date and the like. Selecting Shandong variety.

Schisandra chinensis is dried mature fruit of Schisandra chinensis (Turcz.) Baill of the family Magnoliaceae of perennial deciduous woody, and is known as Schisandra chinensis. Picked up after autumn when the fruit is purple red, dried in the sun or in the shade. Wu Wei Zi is warm in nature and sour and sweet in taste. It enters lung, heart and kidney meridians. Mainly produced in Heilongjiang, Liaoning, Jilin, Hebei and other places, is a traditional genuine product and has excellent quality. Selecting Liaoning variety.

Polygala tenuifolia Willd is dried root of Polygala tenuifolia Willd or Polygala sibirica L. Collecting root in april of lunar calendar, removing impurities, washing, moistening, cutting into segments, and drying. Polygala root, radix Polygalae is warm in nature, bitter and pungent in flavor. It enters heart, lung and kidney meridians. The main products are as follows: for lobule, it is the currently used polygala root, which is produced in the north and south slopes of Qinling mountain; for those with large leaves, it is used today as Siberian polygala root. Selecting Shaanxi varieties.

Taraxacum mongolicum hand-Mazz (taraxacum mongolicum hand.) belonging to Compositae family and perennial herbaceous plants. Digging whole grass with roots in late autumn, removing mud, and drying in the sun for medicinal use. Dandelion is cold in nature, bitter and sweet in taste. It enters liver and kidney meridians. Most areas in China are cultivated, and Anhui variety is selected.

The rhizoma Pinelliae Preparada is tuber of Pinellia Tuber Pinellia ternata (Thunb) Breit of Araceae. Collected in summer and autumn when the stem and leaf are flourishing, removed the outer skin and fibrous root, and dried in the sun. Most areas in China are cultivated, mainly in Sichuan, Hubei, Jiangsu, Anhui and other places. Selecting the Hubei variety.

The processing method comprises the following steps: taking purified pinellia ternate, separating the purified pinellia ternate into different sizes, soaking the purified pinellia ternate in water until no dry cores exist in the purified pinellia ternate, and taking out the purified pinellia ternate; taking an appropriate amount of liquorice (15 kg of liquorice is used per 100kg of purified pinellia tuber), adding water and decocting twice, mixing decoction solutions, pouring into lime liquor prepared by using an appropriate amount of water (10 kg of quicklime is used per 100kg of purified pinellia tuber), stirring uniformly, adding the soaked pinellia tuber, soaking for 1-2 times every day, keeping the pH value of the soaking solution above 12 until the section is yellow and uniform, taking out when the mouth tastes slightly numb and tongue, cleaning, and drying in the shade or drying to obtain the traditional Chinese medicine decoction. Processed ban Xia is warm in nature and pungent in flavor. It enters spleen, stomach and lung meridians.

Scutellariae radix is dried root of Scutellaria baicalensis Georgi (Scutellaria baicalensis Georgi) belonging to Labiatae family. Collected in spring and autumn, removed fibrous root, silt and impurities, boiled in boiling water for 10 min, taken out, sealed, sliced and dried (avoiding solarization). Run off the raw skin and dry in the sun. Baical skullcap root is cold in nature and bitter in taste. It enters lung, gallbladder, spleen, large intestine and small intestine meridians. Produced in provinces and autonomous regions of Hebei, inner Mongolia, Shaanxi, Liaoning, Heilongjiang and the like. The inner Mongolia variety is selected and can not be stored for a long time.

The radix Glycyrrhizae Preparata is root and rhizome of Glycyrrhiza uralensis Fisch (Glycyrrhiza uralensis Fisch), Glycyrrhiza inflata Bat (G.inflataBat) or Glycyrrhiza glabra L (G.glabraL). Collected in spring and autumn, removed fibrous root, and dried in the sun. Slicing into thick pieces, and processing with honey. Distribution in asia, europe, australia, america, etc.; china is mainly distributed in Xinjiang, inner Mongolia, Ningxia, Gansu and Shanxi Shuzhou. The artificial planting of licorice is mainly produced in the Hexi corridor of Xinjiang, inner Mongolia and Gansu, and part of Ningxia. Selecting inner Mongolia varieties.

The preparation method comprises refining Mel in a pot to obtain Chinese Mel, diluting with appropriate amount of boiled water, adding the diluted Mel into clean Glycyrrhrizae radix tablet, stirring, moistening for 3 hr, and turning over for 2 times. Stir-frying the moistened licorice slices for 3-5min with slow fire, uniformly mixing, and taking out of the pot; drying in a constant temperature drying oven at 60 deg.C for 1 hr, taking out when it is not sticky, and cooling. Every 100kg of liquorice tablets are prepared by 25kg of refined honey.

Storage, authenticity identification, quality requirement, purification method and medicine source of raw material medicine

The cassia twig, the dried ginger, the flos caryophyllata and other medicinal materials cannot be stored for a long time because the chemical components contained in the medicinal materials are easy to naturally decompose and volatilize, and the medicinal materials need to be stored by adopting a sealing method and a refrigerating method. If the scutellaria baicalensis is stored for a long time, baicalein and wogonin can be generated by enzymolysis of the baicalin and the wogonin under certain conditions by the aid of the baicalinase, and the antiviral effect of the baicalein and the wogonin is remarkably reduced. The crude drugs such as radix rehmanniae, radix codonopsitis, Chinese date and the like contain more sugar, furfural and similar compounds are generated after decomposition, and the furfural and similar compounds are condensed with certain nitrogen-containing compounds to form brown pigment; or the amino acid in the protein contained in the medicinal materials reacts with reducing sugar to generate macromolecular brown substances, so that the medicinal materials change color and deteriorate. Therefore, except for processed ban Xia, the rest herbs are not always preserved.

The above 16 Chinese medicinal decoction pieces are identified by character identification.

The above 16 Chinese medicinal decoction pieces are respectively sieved to remove silt and powder, removed impurities, removed deteriorated medicinal materials, and dried for use.

The above 16 Chinese medicinal decoction pieces are recorded in Chinese pharmacopoeia.

Auxiliary materials

The water meets the sanitary Standard for Drinking Water of the Ministry of health (GB 5749-2006).

The sodium benzoate meets the national standard GB 1902-2005.

Effect of the invention-clinical application conditions

The effects of the prebiotic anti-infective agents can be seen from the following clinical application conditions, experimental data and experimental examples

The clinical treatment items for the cold comprise main items for relieving aversion to wind, aversion to cold, fever, nasal obstruction and nasal discharge, retching or vomiting, headache, body pain, limb ache, improving self-healing capability and immunologic function and auxiliary items for relieving cough, eliminating phlegm, relieving asthma, sweating, calming, resisting allergy and the like.

The diagnostic standard refers to the Chinese medicinal syndrome diagnostic standard of cold in the guidelines (trial) of clinical research on new Chinese medicinal preparation, and the diagnostic standard of wind-cold exterior deficiency syndrome in the Chinese medicine science compiled by Wangmuilin and Lumegalin^[7].The following criteria were drawn:

aversion to wind and cold, mild fever, no sweating or sweating, aversion to wind, headache, body pain, aching limbs, or neck stiffness, nasal obstruction, clear nasal discharge, retching or vomiting, or itching throat, cough, thin and white sputum, thin and white tongue coating, and superficial, slow or weak pulse.

Exclusion and inclusion criteria for experimental cases

Exclusion criteria

More than 48h after onset;

psychotic patients;

patients with severe diabetes;

a pregnant woman;

flushed face, red, dry tongue without coating, and thready and rapid pulse (wind-heat syndrome due to external infection).

Inclusion criteria were:

the diagnosis standard of the exterior deficiency syndrome of exogenous wind-cold in traditional Chinese medicine is met;

the age is above 3 years old;

patients with qi deficiency, blood deficiency, yang deficiency, yin deficiency (not severe) or cross-type deficiency syndrome (not complete);

common cold lasting for more than 1 year.

Case selection researchers select patients who have a common cold in the past and are difficult to cure in other places (some months have the common cold as long as 10 years) from cold patients who are received for consultation in 2000-2008. Of 29 patients in the treatment group, 13 men and 16 women aged 3-81 years, with an average age of 32 years.

Research method

The Yiyuan anti-cold mixture is orally taken by cold patients, and the clinical curative effect is observed.

240ml of the Yiyuan anti-cold mixture is filled in each bottle.

The preparation is orally administered 40ml for adult once, and is administered by shaking and mixing with warm boiled water 3 times a day. Half the dose of the medicine is taken by patients with yin deficiency syndrome 4-5 times a day; the composition is orally administered to children once in a dose of 10 ml.

Ordering: wind sheltering, attention to warm keeping, rest and rest; avoid smoking, drinking, spicy, uncooked and greasy food.

Criteria for therapeutic effect^[8]

The clinical cure is as follows: the body temperature returns to normal within 3t after treatment, and cold symptoms disappear completely.

The effect is shown: the body temperature returns to normal within 3t after treatment, and most symptoms of cold disappear.

The method has the following advantages: the body temperature is reduced within 3t after treatment, and the main symptoms of the cold partially disappear.

And (4) invalidation: the body temperature is not reduced or increased within 3t, and the main symptoms of the cold are not improved.

Therapeutic Effect of the Main study

Aversion to wind and aversion to cold symptoms: the mild patients are relieved after taking the medicine for 1 time; the severe patients relieved after taking the medicine 2 times.

Nasal obstruction, heavy voice, watery nasal discharge, sneezing and other symptoms: the relief is averagely about 1 hour after the patients with mild symptoms take the medicine, and the relief is averagely about 2 hours after the patients with severe symptoms take the medicine.

Fever symptoms: patients with body temperature of 37.1-37.9 deg.C (axillary temperature) begin to defervesce within about 30min after taking the medicine; patients with the body temperature of 38-38.5 ℃ begin to defervesce after taking the medicine for about 60min averagely.

Wind-cold type retching or vomiting symptoms: the symptoms of the patients begin to improve after taking the medicine for about 15min averagely.

Symptoms of anorexia: the patient began improving 2h after dosing.

Headache, neck rigidity, body pain and soreness of limbs symptoms: the patient with mild symptoms starts to relieve the symptoms after taking the medicine for about 30min on average; the patient without chronic disease begins to relieve after taking the medicine for about 60 min.

Improvement of self-healing ability and immune hypofunction: the patients have the cold in one month and are difficult to cure for a long time, the patients can be generally cured within 3t after taking the Yiyuan anti-influenza mixture, and the cold is difficult to re-cure within 6 months after most of the patients are cured, which indicates that the self-healing capacity and the immune function of the patients are improved.

Therapeutic effects of auxiliary research projects

Cough, thin and white sputum symptoms: the patient with mild symptoms starts to relieve the symptoms after taking the medicine for about 30min on average; the severe disease starts to be relieved after about 60min averagely after being taken.

Symptoms of sweating: during the administration period, patients often have slight sweat, no profuse sweat and no delusions of sweat. The whole body is easy and comfortable after sweating.

The sleep state is as follows: after the patients take the medicine for 2 times on average, the original symptoms of dysphoria and insomnia are gradually improved.

Mood, stress and anti-allergic conditions: after the patient takes the product for 2 times, the mood gradually tends to be stable; after the medicine is taken for 24 hours, the stimulation of the body to various stressors, which is originally manifested as mental stress, is relieved, and the individual patients occasionally have mild reactions and gradually have stable benign moods; after patients who originally suffer from allergic urticaria and allergic rhinitis take the product, the urticaria symptom and the chronic rhinitis symptom are improved, and the product has a certain antiallergic function.

Experimental data

Statistics of treatment efficacy for 3t of drug administration

The total effective rate is as follows: (cure number + significant effect number + effective number)/total case number × 100% — 96.55%;

the total display efficiency is as follows: (cure number + significant effect number)/total case number × 100% ═ 93.10%.

Comparison of the efficacy of YIYUANKANGGAN mixture and other drug therapies in treating common cold

Compared with the clinical curative effect, the common cold patients without chronic diseases in the treatment group take the Yiyuan anti-cold mixture for 2t, the body temperature is normal, the cold symptoms disappear, the original physical strength is not reduced, but is improved, and the work and study can be carried out after recovery. After a patient who frequently suffers from cold takes the medicine for 1t, all symptoms are improved, and the disease can be cured within 3t generally, and the recovery period is about 1 t. Common people are not easy to catch cold again within 3-6 months. While the former patients who often suffer from cold generally receive other treatments, the treatment period is 3-5t or more, and the recovery period is 2t or more. After the cold is cured, the cold is usually cured again at about 15-20 t.

Compared with the cost, the actual drug consumption and the cost, the patients with the cold in the treatment group are quick to recover, the patients are not easy to get a cold again within 3 to 6 months after recovery, and the patients are relatively slow to recover when receiving other therapies; some patients are hospitalized due to the exacerbation of the primary disease or the occurrence of complications caused by cold, so the Yiyuan anti-influenza mixture has obvious advantages in the aspects of cold treatment cost, actual medicine consumption and the like.

Experimental examples

Case 1: a certain woman in the morning is 58 years old, has a dry rest, is diagnosed at 11 and 12 days 2006, and has a cold in the next 3 years, and has arrhythmia and bradycardia for 3 years. The cold comes from the beginning of the treatment. The symptoms are as follows: fatness, pale complexion, purple dark lip, slight aversion to wind-cold sweating, dizziness, headache, cough, insomnia, shortness of breath, chest distress, pale tongue, bright and tender edge tip, thin and white coating, superficial, slow pulse, heart rate of 53 times/min, body temperature of 37.9 ℃. It is indicated for exterior syndrome of wind-cold and exterior deficiency due to qi and blood deficiency. For treatment, it is suitable for dispelling pathogenic wind, relieving depression, benefiting primordial qi and relieving exterior syndrome, and the medicinal mixture for benefiting primordial qi and resisting cold is orally taken for 4 times a day, 40ml each time. After the medicine is taken for 3 days, the cold is cured, and the sleep and arrhythmia are improved. After 2 years of follow-up visit, no secondary cold occurs.

Case 2: wu, a certain woman, 51 years old, retired employee, and then treated 18 days 7 and 2008. The patients with chronic renal insufficiency are in 4 years, and the cold in the next 2 years is the cold in the past. The symptoms are as follows: fatigue, sallow complexion, edema, purple and dark lip color, sweating, aversion to wind, aversion to cold, cold and pain in chest and back, headache, cough, no appetite, nocturia for 3-4 times, dreaminess, insomnia, pale and dark tongue color, thin and white fur, and floating, thready and weak pulse; body temperature 37.6 ℃. The syndrome of exterior deficiency due to wind-cold and yang deficiency, or the syndrome of preponderance of yang deficiency, is diagnosed by the syndrome of exterior deficiency due to both deficiency of qi, blood and yin and exterior deficiency. For treatment, it is suitable for dispelling pathogenic wind, relieving depression, benefiting primordial qi, and relieving exterior syndrome, and the medicinal mixture for benefiting primordial qi and resisting cold is orally administered 20ml for the first time, 40ml for the next time, and 4 times a day. After taking the medicine for 3 days, the cold is cured, the edema is relieved, the phenomenon of mental stress is relieved originally, the night urination is carried out for 2 times every night, and the sleep is improved. After 3 months of follow-up, no secondary cold is seen.

Case 3: when a student in Hanchuan city is in treatment in 9 days 5 and 2007, the student in Hanchuan city will be in treatment in 18 years old, and when the student in 10 months later in 2007, the student in later 1 year will have a cold, and the student in later times will have a cold. The symptoms are as follows: emaciation, pale complexion, sweating, aversion to wind, headache, cough, anorexia, purple red tongue with little coating and superficial and thready pulse; body temperature 38.9 ℃. It is indicated for exterior deficiency syndrome due to wind-cold with yin deficiency. For treating diseases, it is suitable for dispelling pathogenic wind, resolving stagnation, benefiting primordial qi, relieving exterior syndrome, and medicinal mixture for benefiting primordial qi and resisting cold, which is orally administered 20ml once, 4 times a day, and 2 days, and can be used for treating common cold without complicated pharyngolaryngitis. After 2 years of follow-up visit, no secondary cold is seen.

Case 4: somebody of week: male, 10 years old and 3 months old, and children in fairy mountain street in hanchuan city. The doctor visits 2 months and 18 days in 2003, and the milk of the doctor is as follows: the child has a weight of 2.25kg at birth, and has a common cold and cough in the month after bathing in the full month. The cold comes from the beginning of the treatment. The symptoms are as follows: the body type is emaciated and the face is pale, often speaking the words, the tongue is thin and thin, red and tender, without coating, and the pulse is superficial, thready and weak. It is indicated for exterior-affection of wind-cold and exterior deficiency due to deficiency of both qi and yin. For treating diseases, it is suitable for dispelling pathogenic wind, resolving stagnation, benefiting primordial qi, relieving exterior syndrome, and can be orally administered 20ml once, 4 times a day, and 3 days, to treat common cold and improve chronic pharyngitis symptom. Follow-up for 1 year without secondary cold.

Case 5: a certain king, a woman, aged 37 years, teachers, who self-reported that the body is weak, often catch cold, dizziness and palpitation since 1993, and 2 and half years after illness. Since 2 months, the cold is not cured all the time, is light and heavy, and can be sweated when people eat, drink water, wash clothes and walk, and the aversion to wind-cold and cough are caused after the sweat. The disease condition worsens in 2002 by 6, 13 days, and the doctor visits the clinic before. The symptoms are as follows: sallow complexion, mental fatigue, hypo-acoustics, poor breath, aversion to wind, severe aversion to cold, cough, weakness, white foam and thin phlegm. A small, dark red tongue with a slightly greasy coating and a superficial and weak pulse. It is indicated for exterior deficiency syndrome due to wind-cold with exterior deficiency syndrome. For treating diseases, it is suitable for dispelling pathogenic wind, resolving stagnation, benefiting primordial qi, relieving exterior syndrome, and is a medicinal mixture for benefiting primordial qi and resisting common cold, which is orally administered for 20ml for the first day, 40ml for the next time, 4 times a day, and 3 days for treating common cold. The patient is on the cold during the menstruation period, and the color, the menstrual amount and the menstruation period of the menstruation are all more normal than the past without taking other medicines. The follow-up visit is 1 year, and cold is not caused again.

The invention has the advantages of practicability, creativity and novelty.

The raw materials for practically producing the medicine have wide sources, the production process is reasonable, and the quality is controllable; the curative effect for treating the cold is remarkable, and the palatability is good; has no obvious toxic and side effects and high safety, thereby having practicability.

The creative cold is a self-limiting disease and is eliminated mainly by the immunity of a patient. The existing Chinese patent medicines for treating cold in the medicine market focus on improving cold symptoms, and some Chinese patent medicines contain strengthening body resistance components, but can only improve certain symptoms of body resistance deficiency, but cannot solve the disease root of low immune function caused by hypofunction of viscera physiology and deficiency of primordial qi. The Yiyuan anti-influenza mixture has the special efficacy of rapidly recovering the primordial qi of the human body to improve the immunologic function of the human body, and as can be seen from the clinical application condition, the experimental data and the experimental embodiment, the medicine can shorten the treatment period and the recovery period after illness of the weak and chronic disease cold patients, and the total significant efficiency reaches 93.10%; particularly, the probability of deterioration or complication caused by cold of some primary diseases can be reduced, the probability of cold again in the future can be greatly reduced, and the medicine can be used for treating various deficiency syndromes and cold, and is not suitable for being taken by patients with excess heat syndrome cold. The medicine has positive promoting effects on reducing incidence rate of common cold, relieving disease pain and economic burden of common cold patients, reducing time of work error and learning error caused by common cold, and increasing social labor ability. The special efficacy of the Yiyuan anti-cold mixture is realized because the formula of the medicine is injected with a method of treating both symptoms and root causes and focusing on treating the root cause to treat the cold. The treatment of the symptoms requires strong power to attack pathogens, and the weak cold patients have weak self-stabilization capability and are not resistant to strong attack. For the root cause, tonifying methods are needed to supplement the deficiency, improve the physiological functions of the five internal organs and six internal organs, properly deal with the relationship between strengthening the body resistance and eliminating the pathogenic factors, and if the threads cannot be screwed in the aspect of the selection and proportion of the medicines, the defects of closing the door, keeping the hands at the same time and causing no outward pathogen to flow and be released can easily occur. To avoid the contradiction, it is generally advocated to remove exogenous pathogens first and then treat the fundamental deficiency. The formula of the medicine properly deals with the contradiction, strengthens body resistance from multiple aspects without loving pathogenic factors, and uses strong force to attack pathogenic factors without hurting body resistance, which is the creativity of the medicine.

The formula of the novel Yiyuan anti-cold mixture is a brand-new formula, and similar or similar formulas are not recorded in the existing Chinese patent medicine for treating cold; the special efficacy of the traditional Chinese medicine for treating cold is unprecedented, and the traditional Chinese medicine is novel.

[ notes ] to

[1] [2], [3], [4], China medical journal, Vol.4 of 2012, Vol.51, No. 4, Invitrogen: epidemiology and disease burden of common cold

[5] The clinical experience of the section of inexpensive introduces-pathological mechanism and treatment author of cirrhosis: grandfather reaches money and precious pearl author unit: changchun City, traditional Chinese medicine, was published by 2 editors, No. 5, Vol.5, J.Med.Med.Med.Heng, No. 2, page 103, page 104, 1997: chinese traditional and western medicine combined spleen and stomach magazine editors

[6] Refer to the preparation process of the Doudan net traditional Chinese medicine mixture to discuss Jia Chun uploading time: 11/23/2013

[7] Zhengxian Yu based Chinese medicine clinical research guiding principle (trial) Zheng Xiao Yu based Chinese medicine science and technology publishing agency (5 th 1 st edition 58 Wang Yongyan in 2002) and Lumegalin based Chinese medicine science and internal medicine wind-cold exterior deficiency syndrome (10 th 1 st edition 129 pages 1999 of people's health publishing agency (10 th edition)

[8] Zhengxian bamboo major China medicine science and technology publishing agency (Try) Zhengxian bamboo, 5 th month, 1 st edition, 60 pages

[9] The total significant efficiency indicates that the number of actual experimenters is 29, and the number of actual healings is also 29, so the total significant efficiency is 100%. Why are the number of healed people 26, the number of significant 1 and the total significant efficiency 93.10% in the statistical data? This is because the inventors consider the following: in the long run, people who have a life history of being taken away quickly and cold patients with complicated diseases always seek medical advice, and if the conditions are met, the medicine is probably ineffective; or, while effective, the patient may not heal within 3 days, only temporarily, the inventors have not encountered such a situation. Therefore, it is necessary to reduce the number of the "recovery" people by 3, move the "effective" people to the "effective" column 1, move the "effective" column 1 to the "ineffective" column 1, so that the number of the recovery people in the statistical data becomes 26, and the total effectiveness ratio is 93.10%. Therefore, the method for intentionally reducing the total significant efficiency in the statistical data is to make up for the defect that the objective and actual accuracy reflected by the statistical data is influenced due to the limitation of the cold syndrome type of the tested person.

Claims (2)

1. The vitality-benefiting anti-cold mixture is characterized by being prepared from the following raw material medicines in parts by weight: 60 g of cassia twig, 30 g of white paeony root, 30 g of ginger, 300 g of Chinese date, 45 g of honey-fried licorice root, 36 g of astragalus root, 30 g of dried ginger, 102 g of radix rehmanniae recen, 30 g of flos caryophyllata, 60 g of rhizoma anemarrhenae, 30 g of radix codonopsitis, 30 g of Chinese magnoliavine fruit, 30 g of polygala root, 30 g of prepared pinellia tuber, 30 g of baical skullcap root and 30 g of dandelion.

2. The prebiotic and anti-infective agent of claim 1 further characterized by the process of preparation of: firstly, weighing 300 g of Chinese dates, storing in another container, adding 0.5kg of water, and soaking for 2 h; weighing the other 15 traditional Chinese medicinal materials according to the weight parts in claim 1, combining the Chinese dates and the water for soaking the Chinese dates, putting the mixture into a multifunctional traditional Chinese medicine extraction tank, adding 5.5Kg of water into the extraction tank, and soaking the medicine for 60 min; introducing steam into the tank to heat the medicine, introducing steam into the interlayer when the temperature of the medicine reaches 100 ℃, indirectly heating the medicine, and maintaining the temperature in the tank at about 100 ℃ for 3 hours; filtering the decoction, and storing in another container; adding 3Kg of water into the medicine in the tank again, decocting for 3h in the same way, filtering to obtain decoction, squeezing residues, mixing 2 times of decoctions, standing for precipitation for 24h, filtering, sucking supernatant, concentrating to relative density of 1.15 at 90-95 deg.C, adding 0.6g of sodium benzoate, stirring, and mixing to obtain 600ml of the preparation; filling into cleaned, sterilized and dried hot bottle in micro-boiling state, sealing the bottle mouth immediately when the temperature of the hot bottle is about 80 ℃, cooling and sticking labels.