CN105797092B - Yiyuan anti-cold mixture - Google Patents

Abstract

Yiyuan Kanggan Mixture relates to a medicinal composition for treating common cold. Specifically, it is prepared by using plant Chinese herbal medicines as raw materials, and is mainly used for the Chinese patent medicine for treating common cold and the preparation method of the medicine. The technical problems to be solved by the present invention are: 1. to shorten the treatment period and the recovery period after the illness in the weak cold patients; 2. to reduce the probability of the deterioration of the primary disease or the occurrence of complications in the chronically ill patients due to the cold; 3. to reduce the probability of colds The probability that the patient will catch another cold. The main points of the technical solution to solve the above problems are: 1. Use the "Sweat Method" to release muscles, reconcile Ying and Wei, and expel pathogens and go out; 2. Use the "Tonic Method" to regulate and improve the physiological functions of the viscera; 3. Use the "Harmony Method" "Transform the imbalanced qi and blood, viscera, and cold and heat of the body into a balanced state; achieve the therapeutic effect of rapidly improving immunity and dispelling cold, so that the new long-term wind-cold medicine gradually dissipates, and there is no way to pass on, and all diseases heal themselves. Main use: Treat the common cold.

Description

Yiyuan anti-infection mixture

Technical field

The medicine relates to a medicinal composition for treating common cold. Specifically, it is prepared by using plant Chinese herbal medicines as raw materials, and is mainly used for the Chinese patent medicine for treating common cold and the preparation method of the medicine.

Background technique

Overview of the common cold

The common cold is called upper respiratory tract infection, or Shanggan for short, which is a general term that includes acute inflammation of the nasal cavity, pharynx or larynx. The disease can occur throughout the year, and the incidence is higher in winter and spring. People who are frail and suffering from chronic diseases have a longer course of colds, and may cause the deterioration of the primary disease or complications due to colds, and the probability of repeated colds is also high. higher.

Common methods and defects of existing medical technology for treating common cold

Modern medicine mainly uses antipyretic, analgesic, antihistamine and other drugs for symptomatic treatment, plus the use of antiviral drugs or antibiotics for etiological treatment to achieve the purpose of improving symptoms and shortening the course of the disease. If the continuous use of antibiotics or antiviral drugs for a long time, it will lead to weakened immune function of the human body, and patients with frail and chronic diseases often prolong the treatment period, or cause the deterioration of the primary disease and possible complications, etc. side effect. In addition, these two types of drugs also have problems of drug resistance, problems that may lead to drug-induced diseases, and adverse drug reactions.

Traditional Chinese medicine classifies the common cold into the category of external symptoms, and further divides the external symptoms into external cold symptoms, external heat symptoms, and external symptoms caused by deficient people feeling external pathogens. The traditional Chinese medicines used to treat common colds are mostly composed of Chinese medicines that are pungent and dispelling. For the weak cold patients, the medicines that strengthen the body and relieve the table are used for treatment. For example: Shensu Pill is a combination of 11 traditional Chinese medicines such as Codonopsis pilosula, basil leaves, and Pueraria lobata. Clinically, it is commonly used in the treatment of colds caused by frail body and feeling of wind and cold. Another example: Ginseng Baidu Capsule is a combination of 12 traditional Chinese medicines such as ginseng, Duhuo, Qianghuo, and Chuanxiong. It is commonly used clinically for the treatment of colds caused by qi deficiency and exogenous wind-cold-dampness pathogens. Body Deficiency Kanggan Mixture is a combination of eleven traditional Chinese medicines such as Astragalus, Scrophularia, Ophiopogon japonicus, honeysuckle, and Banlangen. Treatment of colds. Such traditional Chinese medicines for strengthening the body and detoxifying the body focus on improving the symptoms of deficiency and colds, but not mainly on improving the body's immunity. In the pathology of common cold patients with weak body, due to the existence of pathological factors of low immune function, the course of colds is longer, and the primary disease may worsen or complications may occur due to colds, and the probability of repeated colds is also higher. high. Even healthy people have varying degrees of immune function decline after suffering from a cold. Although the existing Chinese patent medicines for common cold do not have the same toxic and side effects as Western medicines, they still lack the corresponding ingredients and strengths in terms of replenishing the lost vitality of patients, restoring the body's immunity, and focusing on curing the root cause.

The common cold has caused serious harm to human health

Because the common cold is a self-limiting disease, it needs to rely on the body's immunity to eliminate it, and the pharmaceutical market lacks drugs that focus on restoring the body's immunity and treating the common cold from the source. caused serious harm. According to statistics from authoritative organizations, adults suffer from common colds 2-3 times a year on average, children average 5-7 times a year, and 10%-15% of children have 12 colds a year" ^[1] . People with underlying diseases can significantly increase the number of common colds. The prevalence of colds, for example, the prevalence of colds in diabetics is 3 times that of healthy people, those with respiratory diseases are 13 times that of healthy people, and those with underlying diseases of the circulatory system are 3.5 times that of healthy people ^[2] . The common cold can cause a huge economic burden. According to the data from the United States, 30% of missed school and 40% of missed work are caused by common cold. Common cold causes 2.3 billion days of missed school and 2.5 billion days of missed work every year. There are 2.7 billion doctor visits for the common cold, and the annual cost of over-the-counter drugs used to relieve cough and other cold symptoms is nearly 2 billion US dollars, while the cost of antibacterial drugs is 2.27 billion US dollars. In addition, the treatment of complications and the deterioration of the primary disease make the Medical expenses have increased significantly, increasing the burden of disease ^[3]. The common cold is not common. According to domestic and foreign data, the common cold can not only cause serious social and economic burdens, but also cause serious complications and even threaten the lives of patients. and fatal ^[4] .

Purpose of Invention and Journey of Discovery

Because the common cold is mainly eliminated by the immunity of the human body, the inventor intends to develop a traditional Chinese medicine preparation that can treat the common cold mainly by rapidly improving the immunity. Before 1992, the inventor used the method of strengthening the righteousness and detoxifying the table, using Guizhi Decoction as the basic formula, adding medicines to supplement the yin and yang of qi, blood, and then according to the syndrome of zhengxu, respectively aggravating and nourishing qi, nourishing blood, nourishing yin, or nourishing yin. The dosage of the drugs that help yang or increase the drug to formulate prescriptions to treat the syndrome of exogenous wind-cold and external deficiency, respectively make 6 kinds of preparations, and supply the corresponding 6 kinds of syndrome types (qi deficiency, blood deficiency, yin deficiency, yang deficiency, qi and yin deficiency) It is used for cold patients who suffer from yang and yang losses. Although this method of formulating is accurate, it conforms to the principles of traditional Chinese medicine, and has a certain therapeutic effect, because qi, blood, yin and yang are not only the products of the physiological functions of the zang-fu organs, but also the elements that regulate and enhance the physiological functions of the zang-fu organs. But there are still two shortcomings: First, the intensity of improving immune function is not enough. Second, it is necessary to use 6 kinds of preparations to deal with the treatment of 6 kinds of syndromes. If industrialized production is implemented for the large consumer market, then there will be more investment in the fields of pharmacy, packaging, storage and circulation, such as site occupation, equipment investment, production personnel, management personnel, etc. In order to find a method that can not only improve the curative effect of treating colds, but also reduce the types of preparations, the inventor has gone through another 5 years of exploration.

The main medical data referenced by the inventor when establishing the key technical solution

In June 1997, the inventor saw the article "Introduction of Duan Yinglian's Clinical Experience - Pathological Mechanism and Treatment of Liver Cirrhosis" in the "Chinese Journal of Integrated Traditional Chinese and Western Medicine" ^[5] . Gan Da Yu Decoction is based on the methods of treating liver stagnation, clearing liver heat, nourishing liver yin, and warming meridians. The basic recipe is "Schisandra 10g, dried ginger 10g, Anemarrhena 20g, cassia twig 10g, Gongying 10g, Polygala 10g, Scutellaria 10g, licorice 8g, Shengdi 35g, Gonglixiang 10g, jujube 18, Codonopsis 10g, Pinellia 10g ".

The inventor Hua Cai used Guizhi Decoction, referring to Duan Yinglian's Qinggan Dayu Decoction to promote the recovery of liver, spleen and kidney functions, and the process of treating refractory colds.

The inventor found from the comprehensive pharmacology of Duan Lao's Qinggan Dayu Decoction that this recipe can supplement qi, blood, yin and yang, and also has the effects of regulating, improving and enhancing the physiological functions of the viscera and replenishing the vitality of the human body, which can just be used for the treatment of physical insufficiency. In the prescription of cold medicine, as a part of restoring the physiological function of the viscera, especially the part of improving immunity, together with the medicine to relieve the body, it can achieve the effect of "dispelling wind and stagnation, benefiting Yuan and releasing the body". Therefore, this formula was combined with Guizhi Decoction, and it was applied to the clinical treatment of exogenous wind-cold and external deficiency syndrome. The original recipe uses 10 grams of cinnamon stick, the main function is to warm the meridians, transform qi and move water, so as to treat liver cirrhosis and ascites. In this recipe, Guizhi is changed to 20 grams to strengthen sweating and muscle relieving, evacuate the power of exogenous wind-cold, and is the king medicine; add 10 grams of white peony root and use it in combination with Guizhi to reconcile Yingwei, make sweating without hurting Yin, stop Sweat but do not love evil, it is a minister's medicine; add 10 grams of ginger to help cinnamon stick to sweat and relieve the surface, and can warm the stomach and stop vomiting; add 12 grams of astragalus to replenish the defense qi on the surface, and it is a total adjuvant. The key is to clear the exogenous cold, so 34 grams of Rehmannia glutinosa is used to reduce the power of cold and cold; the original recipe uses 18 jujubes (calculated according to the general size and weight, about 60-80 grams), in order to make full use of jujube to nourish the spleen The effect of nourishing qi, strengthening the body and eliminating pathogenic factors and the convenience of weighing the ingredients, the dosage is changed to 100 grams; the licorice used in the original recipe is 8 grams of raw licorice. Relieves muscle, helps white peony root and battalion, Wu Dazao nourishes qi and reconciles various medicines, so 15 grams of licorice is used instead. The whole recipe consists of: 20 grams of cassia twig, 10 grams of white peony root, 10 grams of ginger, 12 grams of astragalus, 10 grams of dried ginger, 34 grams of rehmannia glutinosa, 20 grams of Anemarrhena, 10 grams of cloves, 10 grams of Codonopsis pilosula, 100 grams of jujube gram, 10 grams of Schisandra, 10 grams of Polygalaceae, 15 grams of Zhigancao, 10 grams of Pinellia, 10 grams of Scutellaria, and 10 grams of Dandelion. It is made into a mixture for the treatment of refractory exogenous wind-cold appearance deficiency syndrome. This is the optimal solution selected after formulating prescriptions—clinical trials—re-formulations—clinical re-trials… After several revisions to the prescription and repeated clinical efficacy tests, the results received unexpected results: the drug It can rapidly improve immune function, shorten the treatment period and recovery period of colds in frail and chronically ill patients, and especially prevent some primary diseases from worsening or complications due to colds. Through follow-up in the future, it is also found that the probability of the patient getting a cold again can be greatly reduced (see "Experimental Example" in "Effect of the Invention" for details).

Similarities and Differences Between Yiyuan Kanggan Mixture and Qinggan Dayu Decoction

In terms of the composition of the prescription, the prescription of Yiyuan Kanggan Mixture is the same as that of Qinggan Dayu Decoction, and the formula of Yiyuan Kanggan Mixture contains almost all the drugs in Qinggan Dayu Decoction. Gan Dayu Decoction uses 8 grams of licorice, while Yiyuan Kanggan Mixture uses 15 grams of Zhigancao. However, the effects of Yiyuan Kanggan Mixture and Qinggan Dayu Decoction are completely different. This is because: First, in terms of the dosage of the drug, the dosage of Guizhi in Yiyuan Kanggan Mixture is twice as much as that in Qinggan Dayu Decoction, so that Guizhi can fully enter and exit the heart-transforming fluid, and the meridians and collaterals can flow out. The effect of sweating, dispersing wind-cold; secondly, Yiyuan Kanggan Mixture has added a medicinal composition with the function of relieving the body: ginger, white peony root and astragalus 3 Chinese herbal medicines. Ginger is pungent and warm, dispelling wind and dispelling cold; astragalus nourishes the spleen and tonifies the lung, strengthens the body and dispels pathogens; the combination of white peony root and cinnamon twig can reconcile the yin and wei, and is conducive to sweating and relieving the exterior. Third, Yiyuan Kanggan Mixture replaces raw licorice in Qinggan Dayu decoction with Zhigancao. Raw licorice is relatively cool, better than clearing away heat and detoxifying to protect the liver; while roasted licorice is relatively warm, and has the ability to invigorate the qi and adjust the urgency and harmonize the medicinal properties. The dosage of jujube for nourishing Huawei was also increased, while the dosage of raw rehmannia glutinosa with cold nature was reduced by 1 gram compared with that in Qinggan Dayu Decoction. The above changes in medicine and dosage established Yiyuan Kanggan Mixture. With the effect of dispelling wind and dispelling cold, the rest of the medicines become adjuvant medicines and adjuvant medicines to improve the body's immunity to help dispel pathogens. As a result of such changes, the Qinggan Dayu Decoction has been transformed from a method that treats liver stagnation, clears liver heat, nourishes liver yin, and clears meridians, supplemented by medicines that help the spleen to invigorate and nourish the kidney to promote the recovery of liver, spleen and kidney functions. The basic formula for the treatment of liver cirrhosis has been transformed into a detoxifying agent that dispels the cold of the lungs, helps the lungs to defend, replenishes the vitality, strengthens the vital energy, promotes the recovery of the functions of the lungs, spleen and kidneys, soothes the wind and relieves the depression, and benefits the yuan and relieves the surface.

content of invention

A Chinese patent medicine for treating common cold, Yiyuan Kanggan Mixture, is made from the following raw materials by weight: 60 grams of cinnamon twig, 30 grams of white peony root, 30 grams of ginger, 36 grams of astragalus, 30 grams of dried ginger, and raw ground 102 grams of yellow, 60 grams of Zhimu, 30 grams of cloves, 30 grams of Codonopsis, 300 grams of jujube, 30 grams of Schisandra, 30 grams of Polygala, 45 grams of Zhigancao, 30 grams of Pinellia, 30 grams of Scutellaria baicalensis, 30 grams of dandelion.

Functions and Indications of Yiyuan Kanggan Mixture

Function: Dispel wind and relieve depression, benefit Yuan and relieve external appearance.

Indications: Exogenous wind-cold manifests deficiency syndrome. It is suitable for people with the following symptoms of common cold: aversion to cold and fever, sweating and aversion to wind, headache, or strong neck, nasal congestion and runny nose, cough, expectoration of white phlegm, restlessness and insomnia, body aches, retching or vomiting, thin tongue coating White, slow or weak pulse.

The medical technical problem to be solved by the present invention and the main points of the technical solution to solve the problem

The medical technical problems to be solved by the present invention are as follows: promoting the frail cold patients to shorten the treatment period and the recovery period after illness; reducing the probability of the deterioration of the primary disease or the occurrence of complications caused by the cold in the chronic disease patients; reducing the probability of the cold patients getting cold again .

The main points of the technical solution to this problem are: using the "Sweat Method" to release muscles, reconcile the yin and guards, and exorcise evil spirits; use the "Replenishing Method" to regulate and improve the physiological functions of the viscera; , Unbalanced viscera and unbalanced cold and heat are transformed into a balanced state; through the comprehensive application of the above 3 programs, the vitality of the human body is enhanced, the righteousness (immunity and cold-dispelling ability) is enhanced, disease is prevented from spreading, and the new long-term wind-cold medicine is gradually dissipated , the symptoms healed themselves.

Pathology of exogenous wind-cold and external deficiency syndrome, the treatment method of Yiyuan Kanggan mixture formula, and the efficacy and characteristics of each drug and its composition

This formula was originally designed for the treatment of exogenous wind-cold-appearing deficiency syndrome (a syndrome of colds) due to physical weakness, but it can also be used for exogenous wind-cold-appearing-deficiency syndrome suffered by ordinary people. People with weak body are most likely to suffer from exogenous wind-cold symptoms. Due to the decline of viscera function, loss of qi, blood, yin and yang, weak vitality, and lack of righteous qi in these people, once they feel wind-cold and cannot consolidate the external due to the weakness of Wei yang, the muscle surface will be loose, aversion to wind and cold, and a slow or floating pulse. Weak; cold pathogens stay in the meridians, causing headaches or discomfort in the neck, soreness of the limbs, and weakness in the limbs and other physical discomforts; the lung meridian, nose and mouth communicate with the outside world, and they are combined with the skin and fur, and are most likely to be injured by wind and cold. Nasal snoring, nasal congestion and runny nose; or retching or vomiting due to disharmony in the stomach; When the Wei qi and the evil qi fight against each other, there is a fever, and the heat causes the skin to open up. Repeated fever and sweating are unhealed, new cold and long-term cold are intertwined, resulting in more deficient Ying and Wei, weaker vitality, more loss of righteousness, and stagnant Qi, so the evil of new chronic disease lingers in confusion. Governance is suitable to dispel wind and relieve depression, and benefit Yuan to relieve the exterior.

In the prescription, Guizhi is pungent, sweet, warm, can dispel wind and dispel cold, clear the heart and yang, warm the chest and abdomen, warm the spleen and stomach, sweat and relieve the muscles to help the defense, warm the meridians, and help the yang to transform the qi for nourishment, so it is the king medicine. White peony root nourishes blood and astringes yin, and can strengthen the function of yin-yin inner guard, so as to treat the symptoms of sweating. It works with cinnamon twigs, disperses and gathers, reconciles yin and yin, makes sweating without hurting yin, and stops sweating and does not love evil. Therefore, it is a medicine for ministers. Ginger is pungent and warm, expelling wind and dispelling cold, can assist Guizhi to sweat and relieve external appearance, help Gui and Paeonia to relieve muscle and camp, and warm the stomach and stop vomiting. Astragalus is sweet and slightly warm, nourishes lung qi, solidifies Wei qi, can produce without sweat, and stop sweating, which can enhance the power of Wei outside. Ginger and astragalus are adjuvant. If a person is full of vitality, exogenous evil should take advantage of the power of the medicine to come out. Because the body is weak, the vitality is insufficient, the camp is weak, and the defense is weak. Although this medicine wants to exorcise the evil outside, the vitality is discouraged. The mild evil does not escape halfway, and the severe evil shrinks in with the vitality. Therefore, the aversion to cold and fever is lingering. . To this end, it is necessary to eliminate cold with multiple targets, improve the physiological functions of the zang-fu organs, and improve the righteousness by cultivating the insufficient vitality. It is also necessary to add medicines that warm the meridians, clear the stagnation, and regulate the Qi mechanism. With the help of medicinal power, the evil spirits can be gradually dissipated. Therefore, dry ginger, which warms the middle and disperses cold, is used to dispel cold pain in the abdomen and abdomen with its pungent and hot nature, dispel visceral deficiency and cold, stop vomiting and diarrhea, and restore the yang of the spleen and stomach; it can also warm the lungs and change the drink to relieve cough, resolve phlegm, and clear the nose. Orifices, in addition to nasal discharge, can help Guizhi to dispel wind and cold. Rehmannia glutinosa is cold in nature, sweet and bitter in taste, nourishes yin and produces body fluid; when combined with dried ginger, it not only has no disadvantages of cold and cool, but also can generate blood and transform body fluid; it can also nourish the yin of lung, spleen and kidney, and help lung, spleen and kidney. Positive. Male cloves are warm in nature, pungent in taste, can warm the middle, reduce the inverse, and stomach, stop vomiting due to deficiency and cold, eliminate cold pain in the confidant, warm the kidneys and help yang; Zhimu is cold, bitter, sweet, nourishing yin and moisturizing dryness, and can diarrhoea rootless The kidney fire can cure the bone steaming caused by sweating; stop the heat of consumptive fatigue, nourish the yin of the source, prevent the warm and dry cinnamon sticks, dried ginger and cloves from producing strong fire and eat qi, consume blood, injure yin and damage yang; Compatibility with cloves can strengthen the power of dried ginger and rehmannia to nourish the lungs, spleen and kidneys. Lung health is the barrier of the body's defense of qi. With the help of lung health, the body will expel pathogens and increase its strength. The spleen is the foundation of the day after tomorrow. If the spleen yin and spleen yang are supported, the qi and blood will be hygienically transformed, and if the guard qi is aided, the lung guard will not be afraid of evil disturbances. Kidney qi is the foundation of lung health, the foundation of yin and yang of the human body, and if kidney yin and kidney yang are enriched, health care will be in an orderly manner, and lung health will be prosperous. In the above four herbs, there are two yin and two yang. Yin depends on the use of yang to transform into camp, and yang depends on the use of yin to transform into Wei. More sweet, warm Codonopsis, jujube, invigorating the spleen and qi, which is conducive to encouraging evil spirits to go out. Jujube can nourish yin and blood, nourish and transform health, and help white peony and ying; when combined with Erjiang, it has the meaning of "Xin Gan diverges into Yang". Schisandra astringes the lungs and invigorates the kidneys, astringes sweat and promotes fluid production. It is in the company of cinnamon twigs and dried ginger. Baishao, Shengdihuang, Zhimu and Schisandra all have the ability to astringe various powders, and can slow down the toughness of cinnamon sticks and dried ginger, so that wind, cold, phlegm and dampness are eliminated without injury to qi and blood. Yuanzhi is pungent and bitter in taste, slightly warm in nature, expectorating phlegm and relieving cough, calming the mind and soothing the nerves. Then Wu ginseng, jujube and grass have the effect of handing over water and fire. Zhigancao assists Guizhi to relieve muscle, helps white peony root and camp, and Wudazao nourishes qi, which has the power of calming the inside and preventing the outside. The combination of two ginger, jujube and licorice can replenish the middle qi, regulate the health of the body, and help sweating. Unblocking the qi machine can benefit all the deficiency and deficiency; it can also protect the viscera, prevent the evil from trapping, and prevent the growth and change of the syndrome. The functional relationship between it and Gui and Shao is for the purpose of accumulation and thin hair, and they are adjuvant. To make Pinellia to remove dampness and phlegm; Scutellaria baicalensis to clear heat and dry dampness; Dandelion removes heat toxin and disperses stagnant qi. The above three herbs are used in combination to remove excess dampness and heat in the formula. Zhigancao reconciles various medicines, and is also used as a medicine. The party comprehensively used the three methods of "Khan", "Replenishing" and "Harmony". "Khan method" and "replenishing method" have been described above, while "harmonious method" is integrated into "Khan method" and "replenishing method", that is, in the process of applying "Khan method" and "replenishing method", the Combined use of cold and heat, tonifying and purging mixture, tonifying the middle and attacking, purging for nourishment; reconciling yin and wei, reconciling liver and spleen, reconciling stomach; The qi in the body resumes its normal rise and fall, and the viscera perform their respective functions, promoting the recovery of vitality from various aspects, the improvement of righteousness, and the elimination of evil qi at multiple targets. All prescriptions are used together, aiming to relieve the body, and comprehensively use the methods of sweating, nourishing the viscera, nourishing the vitality, strengthening the righteousness, relieving the stagnation and balancing the yin and yang, promoting the recovery of the functions of the lungs, spleen and kidneys, and rapidly improving the body's immunity. After a long period of wind and cold, the medicine gradually dissipates, and there is no way for the transmission to change.

Preparation method of Yiyuan Kanggan mixture

First, weigh 300 grams of jujube, store in another container, add 0.5 kg of water, and soak for 2 hours; then weigh the remaining 15 Chinese medicinal materials according to weight, combine the jujube and the water for soaking the jujube, put a multi-energy Chinese medicine extraction tank, and put it in the Add 5.5Kg of water to the tank, soak the medicine for 60min; inject steam into the tank to heat the medicine, when the temperature of the medicine reaches 100°C, turn the steam into the interlayer to heat the medicine indirectly, and maintain the temperature in the tank at about 100°C. Time 3h; filter out the decoction, store it in another container; add 3Kg of water to the medicine in the tank again, the decoction method is the same as above, time 3h, filter the decoction, squeeze the residue, combine the 2 decoctions, stand for precipitation for 24h, filter Then, absorb the supernatant and concentrate it to a relative density of 1.15, which is the relative density at 90-95 °C, add 0.6 g of sodium benzoate, stir, and mix to obtain a dose of 600 ml; In the cleaned, sterilized and dried thermos bottle, the temperature of the thermos bottle during filling is about 80 ℃, immediately seal the bottle mouth, and label it after cooling.

Flow chart

Extraction→purification→concentration→sterilization→packing

3 points about the process and process flow

Regarding the extraction process, because the efficacy of the drug focuses on enhancing the immunity of the human body, rather than releasing the surface mainly through sweating, the production process of additionally extracting the volatile oils of cinnamon sticks and dried ginger by the oil-water separation method is not used.

About the time and frequency of decoction According to the inventor's preparation experience and the research data of Jia Chuanchun and others on the production process of traditional Chinese medicine mixture, the time and frequency of decoction are determined as follows: 3 hours of decoction each time, a total of 2 times of decoction. The research report of Jia Chuanchun et al. on the production process of traditional Chinese medicine mixture pointed out that the rate of obtaining paste is 3.37% higher than that of decocting for 2h each time, and 0.33% lower than that of decocting for 4h. Therefore, the best cooking time is 3 hours each time. 93.4% of the total paste juice obtained by decocting 3 times can be lifted out by decocting twice. Considering factors such as labor costs, energy consumption and equipment depreciation, it is advisable to cook twice. ^[6]

Regarding the later stages of the general production process of the sequential mixture of sterilization and sub-packaging, most of them are sub-packaging first, followed by sterilization. This process adopts boiling sterilization in the final concentration stage, adding sodium benzoate, filling it into a sterilized thermos bottle, and sealing the bottle mouth immediately. It belongs to sterilization first, and then repacking. Sterile workshop and strict process operation procedures can ensure the sterilization effect.

The raw material for preparing Yiyuan anti-infection mixture

Chinese herbal medicine

Cinnamomum cassia is the dry shoot Ramulus Cinnamomi of the evergreen tree plant Cinnamomum cassia Presl in the Lauraceae family. Harvest in spring and summer, remove leaves, soak in water for a while, pick up, smother and moisten until thoroughly, slice, dry, and sieve to remove crumbs. Cinnamon twig is warm in nature, pungent and sweet in taste; it belongs to the bladder, heart and lung meridians. my country's Fujian, China Taiwan, Hainan, Guangdong, Guangxi, Yunnan and other tropical and subtropical regions are cultivated, especially in Guangxi, most of which are artificial pure forests. Choose Guangxi varieties.

Paeonia lactiflora is the root of Paeonia lactiflora Pall (cultivar). Dig the peony root that has been planted for 3 to 4 years, remove the rhizome and fibrous root, wash it, scrape off the rough skin, cook it in boiling water for a while to make it soft, moisten thoroughly, remove and dry, remove impurities, slice and dry in the sun. Paeonia lactiflora is slightly cold in nature, slightly bitter and sour in taste; it belongs to the liver and spleen meridians. It is cultivated all over the country. Produced in Zhejiang, the commodity is called Hangbaishao, with the best quality; produced in Anhui is called Haobaishao, with the largest yield; produced in Sichuan, it is called Chuanbaishao, also known as Zhongjiang peony, and the yield is also large. Select Anhui varieties.

Ginger is the fresh rhizome of Zingiber officinale Rosc. Excavate in autumn and winter, remove fibrous roots and sediment, slice, and use raw. Warm in nature, spicy in taste. Returns the lung, spleen and stomach meridians. Produced everywhere. Select Anhui varieties.

Astragalus is the root of the leguminous herb Astragalus membranaceus (Fisch.) Bunge and Astragalus membranaceus (Fisch.). Harvest in autumn when the plants wither or before germination in spring of the following year, generally in the middle and late September. Use tools to carefully dig out the whole roots that have been planted for 2-3 years. If the growth period is too long, black hearts may occur and the quality will be affected. Avoid bruising the outer skin and broken roots, remove the soil, cut off the reed heads while fresh, trim off the fibrous roots, dry them in the sun, stack them for 1-2 days to regain moisture, and then spread them out and dry them repeatedly until they are completely dry, and straighten the roots. , tied into small bundles, cut into thin slices, the quality is thicker, less wrinkled, yellow-white in color, powdery enough, and sweet in taste. Astragalus is slightly warm in nature and sweet in taste; it belongs to the lung, spleen, liver and kidney meridians. It is cultivated all over the country, and most of the roots in the market are the roots of Astragalus in Inner Mongolia (Astragalus arrows), which are of good quality. A small part is the root of Astragalus membranaceus. Select Inner Mongolia varieties.

Dried ginger is the dried rhizome of Zingiber oj-jicinale Rosc, a perennial herb of the ginger family. After excavation, the stems, leaves and fibrous roots are removed, washed, sun-dried or dried at low temperature, and sliced. Dried ginger is spicy and hot in nature. Return to the spleen, stomach, heart and lung meridians. It is cultivated in most parts of my country, mainly in Sichuan and Guizhou. Select Sichuan varieties.

Rehmannia glutinosa is the tuberous root of the dicotyledonous plant Scrophulariaceae (Rehmannia glutinosa). In autumn, the rhizomes are excavated, the reed heads, stems and leaves, and fibrous roots are removed, and the soil is washed. Rehmannia glutinosa is cold in nature, sweet and bitter in taste, and enters the heart, liver and kidney meridians. Mainly produced in Henan, Liaoning, Hebei, Shandong and Zhejiang, the most famous ones are those produced in Henan, and Henan varieties are selected.

Male lilac is the flower bud of Eugenia caryophyllata Thunb, an evergreen tree plant of the family Myrtaceae. After harvesting, remove the pedicels and dry them in the sun. Public cloves are warm in nature and pungent in taste. Enter the lung, spleen, stomach and kidney meridians. Lilac is one of the traditional imported "Southern medicines" in my country, originating in Moluccas Island in Indonesia and Sanhabar Island in Tanzania. Now Indonesia's Penang, Sumatra, Java and the Malay Peninsula, Vietnam and Oceania and other countries and regions are produced. It was successfully introduced in my country in the 1950s and cultivated in Hainan Province, Leizhou Peninsula, Guangdong, Guangxi and other places. Choose Guangxi varieties.

Anemarrhena is the dry rhizome of Anemarrhenaasphodeloides Bunge, a perennial herb monocotyledonous plant Liliaceae. In spring and autumn, 2-3 years old Anemarrhena root can be harvested and planted. It is better to harvest in autumn, remove stems, fibrous roots and sediment, and dry it in the sun. Or remove the outer skin, dry in a ventilated place, and slice for later use. Anemarrhena is cold in nature, bitter in taste and sweet; it belongs to the lung, stomach and kidney meridians. Mainly produced in Hebei, Shanxi, Inner Mongolia, Shaanxi and Northeast China. Use Hebei varieties.

Codonopsis is the perennial herb Codonopsis, Codonopsis, Sichuan Codonopsis and the root of Codonopsis (West Codonopsis) Codonopsis pilosula Nannf.var.modesta (Nannf.) L.T.Shen or Codonopsis Codonopsis tangshen Oliv dry roots. It is named after its origin in Shangdang Basin, Shanxi, and is mostly produced in Wutai County, so it is called "Taiwan Codonopsis". Taiwan Codonopsis is a treasure of Codonopsis due to its excellent quality. Excavated in autumn, washed and sun-dried. Codonopsis is flat, sweet and slightly sour. Return to the spleen and lung meridians. Mainly produced in Shanxi, mostly cultivated products. Northeast, North China and Shaanxi, Ningxia, Gansu, Qinghai, Henan, Sichuan, Yunnan, Tibet and other places are also produced. Choose Henan varieties.

Jujube is the dry ripe fruit of the jujube Ziziphus jujuba Mill.var.inermis (Bunge) Rehd. Also known as red jujube, the fruit is ripe from August to September. After picking, impurities are removed and dried in the sun. Jujube is flat in nature and sweet in taste. Return to the spleen and stomach meridians. It is produced in most parts of the country, and the jujubes produced in Shandong, Hebei, Shanxi, Shaanxi and Anhui provinces account for more than 80% of the total annual output. The famous jujube varieties in my country include Shanxi Yellow River Tan jujube, Wufo jujube, Shandong jujube, Sihong jujube, Fuping jujube, Zanhuang jujube, Hami jujube, Xinzheng jujube, etc. Select Shandong varieties.

Schisandra chinensis is the dry ripe fruit of the perennial deciduous vine Magnoliaceae Schisandra chinensis (Turcz.) Baill, commonly known as Schisandra chinensis. After autumn, the fruit is picked when it is purple-red and dried in the sun or shade. Schisandra is warm, sour and sweet. Returns the lung, heart and kidney meridians. Mainly produced in Heilongjiang, Liaoning, Jilin, Hebei and other places, it is a traditional authentic product with good quality. Use Liaoning varieties.

Polygala is the dried root of Polygala tenuifolia Willd or Polygalasibirica L. Roots were harvested in April of the lunar calendar, impurities were removed, washed slightly, moistened thoroughly, cut into sections, and dried. Yuanzhi is warm in nature, bitter and acrid in taste. Return to the heart, lung and kidney meridians. Its mainstream products: the small-leafed ones are the Polygala for today's use, and they are produced on both the southern and northern slopes of the Qinling Mountains; Shaanxi varieties are selected.

Dandelion (araxacum mongolicum Hand.-Mazz) is a perennial herb. In late autumn, the whole grass with roots is excavated, removed from the mud, and dried in the sun for medicinal use. Dandelion is cold, bitter and sweet. Return to the liver and kidney meridians. It is cultivated in most parts of China, and Anhui varieties are selected.

The system of Pinellia is the tuber of Pinellia ternata (Thunb) Breit of the Araceae. In summer and autumn, when the stems and leaves are lush, excavate, remove the outer skin and fibrous roots, and dry in the sun. It is cultivated in most parts of China, mainly in Sichuan, Hubei, Jiangsu, Anhui and other places. Select Hubei varieties.

Processing method: Take net Pinellia, separate the size, soak in water until there is no dry heart, take it out; take an appropriate amount of licorice (15kg of licorice per 100kg of net pinellia), add water and decocted twice, combine the decoction, and pour in an appropriate amount of licorice. In the lime liquid made of water (10kg of quicklime per 100kg of net Pinellia sinensis), stir well, add the soaked Pinellia sinensis, soak, stir 1-2 times a day, and keep the pH value of the soaking liquid above 12, to the profile When the yellow color is uniform, and the taste is slightly numb, take it out, wash it, dry it in the shade or dry it. The system of Pinellia is warm in nature and spicy in taste. Returns to the spleen, stomach and lung meridians.

Scutellaria baicalensis is the dried root of Scutellaria baicalensis Georgi. Excavate in spring and autumn, remove fibrous roots, sediment and impurities, cook in boiling water for 10 minutes, take out, smother, cut into thin slices, and dry (avoid exposure to sunlight). Rip off the rough skin and dry in the sun. Scutellaria baicalensis is cold in nature and bitter in taste. Returns the lung, gallbladder, spleen, large intestine and small intestine meridians. Produced in Hebei, Inner Mongolia, Shaanxi, Liaoning, Heilongjiang and other provinces and autonomous regions. Use Inner Mongolia varieties, do not store for too long.

Glycyrrhiza is the root and rhizome of dicotyledonous plants Leguminosae Glycyrrhiza uralensis Fisch, G. inflataBat or G. glabraL. Excavated in spring and autumn, removed fibrous roots, and sun-dried. Cut into thick slices and grilled with honey. It is distributed in Asia, Europe, Australia, America and other places; China is mainly distributed in Xinjiang, Inner Mongolia, Ningxia, Gansu, and Shanxi Shuozhou. Artificially planted licorice is mainly produced in the Hexi Corridor of Xinjiang, Inner Mongolia, Gansu, and parts of Ningxia. Select Inner Mongolia varieties.

Processing method: Put the honey in a pot and make it into medium honey, take the refined honey, dilute it with an appropriate amount of boiling water, pour it into the net licorice slices, mix well, simmer for 3 hours, and turn it twice in the middle. Stir-fry the thoroughly moistened licorice slices for 3-5min with simmering heat to make them evenly mixed, and take out of the pot; dry in a constant temperature drying oven at a temperature of 60 ℃, dry at a constant temperature for 1 hour, take it out when it is not sticky, and let it cool. For every 100kg of licorice tablets, use 25kg of refined honey.

Storage, authenticity identification, quality requirements, purification methods and drug sources of APIs

Cinnamon sticks, dried ginger, cloves and other medicinal materials cannot be stored for a long time because the chemical components contained in them are easily decomposed and volatilized, and need to be preserved by sealing and refrigeration. If baicalin is stored for a long time, the baicalinase in it will hydrolyze baicalin and wogonin under certain conditions to generate baicalein and wogonin, and its antiviral effect will be significantly reduced. Rehmannia glutinosa, Codonopsis, jujube and other medicinal materials contain a lot of sugar, and after their decomposition, furfural and its similar compounds are produced, which are condensed with some nitrogen-containing compounds to form brown pigments; The brown substance of macromolecules is formed, which makes the medicinal materials discolor and deteriorate. Therefore, except for the production of Pinellia, the other medicinal materials should not be used.

The above 16 Chinese herbal decoction pieces were all identified by character identification to identify their authenticity.

The above 16 Chinese herbal decoction pieces were all sieved to remove the sediment and debris, and the sundries were removed, and the spoiled medicinal materials were removed, dried and set aside.

The above 16 herbal decoction pieces are all recorded in the Chinese Pharmacopoeia.

Excipients

The water is in line with the Hygienic Standards for Drinking Water (GB5749-2006) of the Ministry of Health.

Sodium benzoate complies with the national standard GB 1902-2005.

The effect of the invention - clinical application

The invention effect of Yiyuan Kanggan Mixture can be seen from the following clinical application, experimental data and experimental examples

Items clinically used in the treatment of colds include relieving aversion to wind, chills, fever, nasal congestion and runny nose, retching or vomiting, headache, body pain, and limb aches, improving self-healing ability and immune function and other major items, as well as relieving cough, expectorant, Asthma, sweating, sedation, anti-allergic and other auxiliary items.

The diagnostic criteria refer to the TCM syndrome diagnostic criteria for colds in "Guiding Principles of Clinical Research on New Chinese Medicines (Trial)" and the "Traditional Chinese Medicine Internal Medicine" edited by Wang Yongyan and Lu Zhaolin on the diagnostic criteria for wind-cold surface deficiency syndrome ^[7]. The formulas are as follows standard:

Severe aversion to wind and cold, mild fever, no sweating or sweating, aversion to wind, headache, body pain, soreness in limbs, or strong neck, heavy nasal congestion, frequent runny nose, retching or vomiting, or itchy throat, cough, vomiting Thin and white phlegm, thin white and moist tongue coating, and slow or weak pulse.

Exclusion and inclusion criteria of experimental cases

Exclusion criteria

More than 48 hours after onset;

Mentally ill;

Severely diabetic patients;

pregnant woman;

Flush complexion, red and dry tongue without coating, and thin pulse (exogenous wind-heat syndrome).

Inclusion criteria:

Conform to the diagnostic criteria of TCM on exogenous wind-cold manifesting deficiency syndrome;

Aged over 3 years old;

The patient has qi deficiency, blood deficiency, yang deficiency, yin deficiency (not serious) or cross-type deficiency syndrome (not all of them);

Frequent colds that last for more than 1 year.

Case selection The researchers selected from the cold patients admitted from 2000 to 2008, the patients who often had colds in the past and were refractory to other treatments for a long time (some colds lasted as long as 10 years). Among the 29 patients in the treatment group, there were 13 males and 16 females, ranging in age from 3 to 81 years old, with an average age of 32 years.

Research methods

Oral administration of Yiyuan Kanggan mixture to cold patients to observe the clinical curative effect.

Yiyuan anti-infection mixture, 240ml per bottle.

Adults take 40ml orally at a time, shake well when taking, mix with warm water, 3 times a day. Patients with yin deficiency syndrome take half dose, 4-5 times a day; children take 10ml orally at a time.

Doctor's advice: take shelter from the wind, keep warm, rest and recuperate; avoid smoking, alcohol and spicy, cold and greasy food.

Efficacy criteria ^[8]

Clinical recovery: The body temperature returned to normal within 3t of treatment, and all cold symptoms disappeared.

Significantly effective: The body temperature returned to normal within 3t of treatment, and most of the symptoms of colds disappeared.

Effective: within 3t of treatment, the body temperature is lower than before, and the main symptoms of colds partially disappear.

Ineffective: the body temperature did not drop or rise within 3t of treatment, and the main symptoms of colds did not improve.

Therapeutic effects of the main research project

Symptoms of aversion to wind and cold: mild patients relieved after taking the medicine once; severe patients relieved after taking the medicine twice.

Nasal congestion, heavy voice, runny nose, sneezing and other symptoms: mild patients relieved on average about 1 hour after taking the drug, and severe patients relieved on average about 2 hours after taking the drug.

Fever symptoms: Patients with a body temperature of 37.1-37.9°C (armpit temperature) start to cool down on average about 30 minutes after taking the medicine; patients with a body temperature of 38-38.5°C start to cool down on average about 60 minutes after taking the medicine.

Wind-cold retching or vomiting symptoms: The patient's symptoms began to improve on average about 15 minutes after taking the drug.

Anorexia symptoms: The patient began to improve 2 hours after taking the drug.

Symptoms of headache, neck strength, body pain and limb soreness: mild patients start to relieve on average about 30 minutes after taking the medicine; severe patients without chronic diseases start to relieve about 60 minutes after taking the medicine.

Improvement of self-healing ability and low immune function: The patient has had a cold every month, and it is difficult to recover after long-term treatment. After taking Yiyuan Anti-Infection Mixture, he can generally recover within 3T, and most patients are not easy to recover within 6 months after recovery. Cold, indicating that the patient's self-healing ability and immune function have been improved.

Therapeutic effects of ancillary research projects

Symptoms of cough and thin white phlegm: mild patients start to relieve on average about 30 minutes after taking the medicine; severe patients start to relieve on average about 60 minutes after taking the medicine.

Symptoms of sweating: During the medication, patients often see micro sweats, but no profuse sweating and paradoxical sweating. The whole body is relaxed and comfortable after sweating.

Sleep status: After taking the medicine for an average of 2 times, the original symptoms of restlessness and insomnia were gradually improved.

Emotion, stress and anti-allergic conditions: After taking this product for two times, the patient's mood gradually becomes stable; after 24 hours of taking the drug, the body's stimulation of various stressors, which originally manifested as mental stress, is relieved, and individual patients occasionally appear The reaction was also calmer than before, and a more stable benign mood gradually appeared; after taking this product, the symptoms of urticaria and chronic rhinitis were improved in patients who had previously suffered from allergic urticaria and allergic rhinitis, indicating that this product has a certain anti-inflammatory effect. Allergy function.

Experimental data

Statistics on the therapeutic effect of administration of 3t

Total effective rate: (number of cured + number of marked effect + number of effective) / total number of cases × 100% = 96.55%;

Total effective rate: (number of cured + number of marked effect)/total number of cases×100%=93.10%.

Comparison of Yiyuan Kanggan Mixture and Other Drug Therapy in Treating Colds

Comparison of clinical curative effect The general cold patients without chronic diseases in the treatment group had normal body temperature within 2t of taking Yiyuan Kanggan Mixture, the cold symptoms disappeared, and the original physical strength not only did not decrease, but improved, and they could work and work after recovery. study. After taking 1t of colds for patients who have suffered from frequent colds, their symptoms are improved, and they can generally be cured within 3t, and the recovery period is about 1t. Most people are less likely to catch a cold within 3-6 months. When the patients who have suffered from frequent colds receive other treatments, the treatment period is generally 3-5t or more, and the recovery period is more than 2t. After the cold is cured, at about 15-20t, it is often common to catch a cold again.

Comparison of cost, actual drug consumption and cost Because the cold patients in the treatment group recovered quickly, they were not easy to catch a cold again within 3-6 months after recovery, and they had a relatively slow recovery when they received other treatments; Caused by the deterioration of the primary disease or the occurrence of complications and hospitalization, Yiyuan Kanggan Mixture has obvious advantages in terms of the cost of treating colds and the actual consumption of drugs.

Experimental Example

Case 1: Zeng Moumou, male, 58 years old, retired cadre, went to the doctor on November 12, 2006. Zeng Mou had a cold every month for the past 3 years, and also suffered from arrhythmia and bradycardia for 3 years. I have a cold again today, so I came to see a doctor. Symptoms: body fat, pale complexion, dark purple lips, sweating slightly aversion to wind and cold, dizziness, headache, cough, insomnia after waking up, shortness of breath, chest tightness, pale tongue, glossy edge, thin white coating, pulse Floating slowly, late, heart rate 53 beats/min, body temperature 37.9 ℃. Diagnosed as deficiency syndrome of qi deficiency and blood deficiency outside the feeling of wind and cold. For the treatment of expelling wind and stagnation, Yiyuan detoxification, medicinal Yiyuan Kanggan Mixture, 40ml orally each time, 4 times a day. After taking it for 3 days, the cold was cured, and the sleep and arrhythmia improved. Follow-up for 2 years, no cold again.

Case 2: Wu Moumou, female, 51 years old, retired worker, went to the doctor on July 18, 2008. Suffering from chronic renal insufficiency for 4 years, I have had a cold every month for the past 2 years, and now I have a cold again, so I came to see a doctor. Symptoms: fatigue, pale complexion, edema, dark purple lips, sweating, aversion to wind and cold, cold chest and back pain, headache, cough, inability to eat, 3-4 times of nocturnal urination, more dreams and less sleepiness, tongue color Dull, thin white fur, thin and weak pulse; body temperature 37.6 ℃. Diagnosed as deficiency of both qi, blood and yin and yang, the syndrome of deficiency of wind and cold, and the excess of yang deficiency. For the treatment of expelling wind and depressing stagnation, Yiyuan relieves the table, and medicinal Yiyuan Kanggan Mixture, take 20ml each time on the first day, and then 40ml each time, 4 times a day. After taking it for 3 days, the cold was cured, the swelling was relieved, and the phenomenon of mental tension was relieved, and the sleep was improved twice a night. During the 3-month follow-up, no cold was found again.

Case 3: He Moumou, male, 18 years old, student in Hanchuan City, went to see a doctor on May 9, 2007. He Mou had a cold every month for more than a year and was complicated by pharyngitis. He has a cold again today and came to see a doctor. Symptoms: thin body, pale complexion, sweating, aversion to wind, headache, cough, anorexia, purplish red tongue with little coating, floating and thin pulse; body temperature 38.9°C. Diagnosed as syndrome of yin deficiency and wind-cold exterior deficiency. The treatment is suitable for dispelling wind and stagnation, and Yiyuan relieves the table. The medicinal Yiyuan Kanggan Mixture is taken orally 20ml at a time, 4 times a day, for 2 days, the cold is cured, and there is no concomitant pharyngitis. During the 2-year follow-up, no recurrence was found.

Case 4: Zhou Moumou: Male, 10 years old and 3 months old, child in Fairy Mountain Street, Hanchuan City. On February 18, 2003, he went to the doctor and his grandmother stated that the child weighed 2.25kg at birth. After taking a bath at the full moon, he had a cold and cough. I have a cold again today, so I came to see a doctor. Symptoms and symptoms: body weight loss, pale complexion, often making a "squeaky" sound, thin, red and tender tongue, no coating, floating and weak pulse. Diagnosed as deficiency of both qi and yin outside the sense of wind and cold. It is suitable for dispelling wind and stagnation, and benefiting Yuan to relieve external appearance. The medicinal Yiyuan Kanggan Mixture is taken orally at a time, 20ml, 4 times a day, for 3 days, the cold is cured, and the symptoms of chronic pharyngitis are also improved. Follow-up for 1 year, no cold again.

Case 5: Wang Moumou, female, 37 years old, teacher, said that she had been weak since she was a child. Since 1993, she has often caught colds, dizziness, and palpitations. She had been on sick leave for two and a half years. In the past 2 months, the cold has been unhealed, sometimes mild and sometimes severe. After eating, drinking, washing, and walking, I sweat. After sweating, I have aversion to cold and cough. On June 13, 2002, her condition worsened and she came to see a doctor. Symptoms and symptoms: pale complexion, mental fatigue, fatigue, low voice, weak breath, severe aversion to wind and cold, weak cough, spit white foam and thin phlegm. The tongue is thin and small, dark red in color, slightly greasy fur, and weak pulse. Diagnosed as deficiency of both qi, blood and yin and yang, the external sensation is wind-cold and the syndrome is manifested as deficiency. It is suitable for dispelling wind and stagnation, and benefiting Yuan to relieve external appearance. Medicinal Yiyuan Kanggan Mixture is taken orally with 20ml once on the first day, and 40ml once on the next day, 4 times a day. After taking it for 3 days, the cold will be cured. The patient's cold is during menstruation, and without taking other medicines, the color, volume and menstrual period of menstruation are normal than before. During the 1-year follow-up, there was no recurrence of colds.

Summary of the effect of the invention It can be seen from the above clinical effects that the invention has practicality, creativity and novelty.

Practicality The raw materials for the production of the medicine are widely sourced, the production process is reasonable, and the quality is controllable; the curative effect of treating colds is remarkable, and the palatability is good; there is no obvious toxic and side effects, and the safety is high, so it is practical.

Creative Cold is a self-limiting disease, mainly rely on the patient's own immunity to eliminate. The existing Chinese patent medicines for the treatment of colds in the pharmaceutical market focus on improving the symptoms of colds. Although some Chinese patent medicines contain ingredients that strengthen the body, they can only improve some symptoms of deficiency, but cannot solve the problems caused by the decline of the physiological functions of the viscera and vitality. The root cause of the disease is loss and low immune function. Yiyuan Kanggan Mixture has the special effect of quickly restoring the vitality of the human body to improve the immune function of the body. It can be seen from the above-mentioned clinical application, experimental data and experimental examples that the drug can shorten the risk of illness caused by frail and chronic cold patients. During the treatment period and the recovery period after the illness, the total effective rate is 93.10%; in particular, it can reduce the probability of deterioration or complications of some primary diseases caused by colds, and can also greatly reduce the probability of future colds and can be used. For the treatment of various deficiency syndromes and colds, it is not suitable for patients with colds with excess heat syndrome. The drug will play a positive role in reducing the incidence of human colds, alleviating the pain and economic burden of cold patients, reducing the time of missed work and school due to colds, and increasing social labor capacity. The reason why Yiyuan Kanggan Mixture can have the above special effects is because the formula of this medicine is injected with the method of "treat both the symptoms and the root causes" to treat the common cold. To treat the symptoms, it is necessary to use force to attack the evil, and the weak cold patients have weak self-stabilization ability and are not resistant to strong attacks. To cure the root cause, it is necessary to make up for its deficiencies, improve the physiological functions of the internal organs, and properly deal with the relationship between strengthening the righteousness and eliminating pathogenic factors. The evils of the lingering evil. In order to avoid this pair of contradictions, it is generally advocated to eliminate external evils first, and then treat the root deficiency. The formula of the medicine properly handles this pair of contradictions. It supports the righteous in many ways without loving the evil, and uses great strength to attack the evil without harming the righteous. This is the creativity of the medicine.

The formula of Novel Yiyuan Anti-Infection Mixture is a brand-new formula. There is no similar or similar formula recorded in the existing Chinese patent medicines for the treatment of colds. There is no precedent for its special efficacy in the treatment of colds. Novelty of the drug.

【Notes】

[1], [2], [3], [4], Chinese Journal of Internal Medicine, Volume 51, Issue 4, April 2012, Yin Kaisheng: "Epidemiology and Disease Burden of the Common Cold"

[5] Duan Yinglian's clinical experience introduction - pathological mechanism and treatment of liver cirrhosis A total of 2 pages edited and published by: Editorial Department of Chinese Journal of Integrated Traditional Chinese and Western Medicine Spleen and Stomach

[6] See Douding.com, Discussion on the Preparation Technology of Traditional Chinese Medicine Mixtures by Jia Chuanchun Uploaded on: November 23, 2013

[7] Guidelines for Clinical Research of New Drugs of Traditional Chinese Medicine (Trial), edited by Zheng Xiaoyu, China Medical Science and Technology Press, May 2002, 1st edition, page 58 1st edition of the month page 129

[8] Guiding principles for clinical research of new Chinese medicines (trial), editor-in-chief of Zheng Xiaoyu, China Medical Science and Technology Press, May 2002, 1st edition, p. 60

[9] Explanation on the total apparent efficiency The actual number of people in the experiment is 29, and the actual number of people cured is also 29, so the total apparent efficiency should be 100%. Why are there 26 recovered persons in the statistics, 1 markedly effective, and the total marked efficiency is 93.10%? This is because the inventors have taken into account the following situations: In the long run, there will always be people who are about to complete their life course and cold patients with complicated conditions to seek medical treatment. If such a situation is encountered, the drug may be ineffective; However, the patient may not recover within 3 days, but the inventor has not encountered such a situation for the time being. Therefore, it is necessary to reduce the number of "recovered" people by 3, move 1 person into the "marked" column, move 1 person into the "effective" column, and move 1 person into the "invalid" column, so the number of people who have recovered in the statistics becomes 26. The total apparent efficiency is 93.10%. The purpose of deliberately reducing the total apparent efficiency in the statistical data is to make up for the deficiency of the objective reality reflected in the statistical data because of the limitations of the cold syndrome type of the subjects.

Claims (2)

1. The vitality-benefiting anti-cold mixture is characterized by being prepared from the following raw material medicines in parts by weight: 60 g of cassia twig, 30 g of white paeony root, 30 g of ginger, 300 g of Chinese date, 45 g of honey-fried licorice root, 36 g of astragalus root, 30 g of dried ginger, 102 g of radix rehmanniae recen, 30 g of flos caryophyllata, 60 g of rhizoma anemarrhenae, 30 g of radix codonopsitis, 30 g of Chinese magnoliavine fruit, 30 g of polygala root, 30 g of prepared pinellia tuber, 30 g of baical skullcap root and 30 g of dandelion.

2. The prebiotic and anti-infective agent of claim 1 further characterized by the process of preparation of: firstly, weighing 300 g of Chinese dates, storing in another container, adding 0.5kg of water, and soaking for 2 h; weighing the other 15 traditional Chinese medicinal materials according to the weight parts in claim 1, combining the Chinese dates and the water for soaking the Chinese dates, putting the mixture into a multifunctional traditional Chinese medicine extraction tank, adding 5.5Kg of water into the extraction tank, and soaking the medicine for 60 min; introducing steam into the tank to heat the medicine, introducing steam into the interlayer when the temperature of the medicine reaches 100 ℃, indirectly heating the medicine, and maintaining the temperature in the tank at about 100 ℃ for 3 hours; filtering the decoction, and storing in another container; adding 3Kg of water into the medicine in the tank again, decocting for 3h in the same way, filtering to obtain decoction, squeezing residues, mixing 2 times of decoctions, standing for precipitation for 24h, filtering, sucking supernatant, concentrating to relative density of 1.15 at 90-95 deg.C, adding 0.6g of sodium benzoate, stirring, and mixing to obtain 600ml of the preparation; filling into cleaned, sterilized and dried hot bottle in micro-boiling state, sealing the bottle mouth immediately when the temperature of the hot bottle is about 80 ℃, cooling and sticking labels.