CN1733204A - Chinese traditional medicine preparation for resolving phlegm and relieving cough and process for preparing the same - Google Patents
Chinese traditional medicine preparation for resolving phlegm and relieving cough and process for preparing the same Download PDFInfo
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- CN1733204A CN1733204A CN 200510031943 CN200510031943A CN1733204A CN 1733204 A CN1733204 A CN 1733204A CN 200510031943 CN200510031943 CN 200510031943 CN 200510031943 A CN200510031943 A CN 200510031943A CN 1733204 A CN1733204 A CN 1733204A
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Abstract
The invention relates to a Chinese medicinal composition for resolving phlegm and relieving cough and the process for preparation, wherein the composition is mainly prepared from pummelo peel, dried orange peel, poria cocos, bitter apricot seed, pericarpium trichosanthis, thunberg fritillary bulb, dried rehmannia root, lilyturf root, gypsum, pinellia tuber, root of ballon flower, purple perilla seed, aster, licorice root, coltsfoot flower. The preparation can be made into lozenges or soft capsules.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, relate in particular to Chinese medicine preparation of a kind of preventing phlegm from forming and stopping coughing and preparation method thereof.
Background technology:
Drop pill in the Chinese medicine preparation or micropill or buccal tablet or soft capsule, change dosage form and manage as new drug research according to the relevant laws and regulations of China's drug control as a kind of pharmaceutical dosage form.The existing dosage form of this product is a granule, has listed the national drug standards in.
The tangerine particulate technology features of the Chinese medicine preparation of existing preventing phlegm from forming and stopping coughing is to get ten five tastes in the prescription, decocts with water secondary, each 2 hours, collecting decoction, staticly settled 6～8 hours, and filtered, filtrate is concentrated into the clear paste that relative density is 1.32～1.34 (70～75 ℃).1 part of qinghuo reagent adds 3 parts of cane sugar powders, and 1 part in dextrin and ethanol are made granule in right amount, drying, promptly.
Inconvenience is carried, is taken in the tangerine electuary existence of the Chinese medicine preparation of existing preventing phlegm from forming and stopping coughing, need take shortcomings such as poor stability after mixing it with hot water.
Summary of the invention:
The purpose of this invention is to provide Chinese medicine preparation of a kind of preventing phlegm from forming and stopping coughing and preparation method thereof, overcome the above-mentioned drawback of prior art, improve the quality and the curative effect of product, satisfy the needs of medical treatment better.
The objective of the invention is to be achieved through the following technical solutions.
The Chinese medicine preparation of preventing phlegm from forming and stopping coughing, it is that main component is tangerine drop pill or micropill or buccal tablet or the soft capsule of Exocarpium Citri Grandis, Pericarpium Citri Reticulatae, Poria, Semen Armeniacae Amarum, Pericarpium Trichosanthis, Bulbus Fritillariae Thunbergii, Radix Rehmanniae, Radix Ophiopogonis, Gypsum Fibrosum, Rhizoma Pinelliae (processed), Radix Platycodonis, Fructus Perillae (stir-fry), Radix Asteris, Radix Glycyrrhizae, Flos Farfarae.
Its preparation method is:
(1) medicine constituent and percentage by weight thereof are as follows:
Exocarpium Citri Grandis 8～15%, Pericarpium Citri Reticulatae, Poria, Semen Armeniacae Amarum, Pericarpium Trichosanthis, Bulbus Fritillariae Thunbergii, Radix Rehmanniae, Radix Ophiopogonis, Gypsum Fibrosum each 5～10%, Rhizoma Pinelliae (processed), Radix Platycodonis, Fructus Perillae (stir-frys), Radix Asteris each 2～8%, Radix Glycyrrhizae, Flos Farfarae respectively 1～5%;
Drug main wants the optimum weight percentage ratio of constituent to be:
Exocarpium Citri Grandis 11%, Pericarpium Citri Reticulatae, Poria, Semen Armeniacae Amarum, Pericarpium Trichosanthis, Bulbus Fritillariae Thunbergii, Radix Rehmanniae, Radix Ophiopogonis, Gypsum Fibrosum each 7.4%, Rhizoma Pinelliae (processed), Radix Platycodonis, Fructus Perillae (stir-frys), Radix Asteris each 5.6%, Radix Glycyrrhizae, Flos Farfarae respectively 3.7%;
(2) above ten five tastes medical materials decoct with water 1～3 time, and each 1～3 hour, collecting decoction staticly settled 4～10 hours, filter, and filtrate is concentrated into the clear paste that relative density is 1.30～1.40 (60～80 ℃), and drying is ground into fine drug powder, and is standby;
(3) get the fine drug powder of (2) gained, after the adding appropriate amount of auxiliary materials, be made into drop pill or micropill or buccal tablet or soft capsule;
(4) with one or more or other suitable adjuvant of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188, use with by arbitrary proportion, be heated to the fine drug powder that adds (2) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70～100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, with the drop pill drop of molding to the greatest extent and remove coolant, dry coationg promptly.
(5) get the hybrid medicine fine powder of (2) gained, add appropriate amount of auxiliary materials after, mix homogeneously is granulated, coating or coating are not made the micropill of diameter less than 2.5mm;
The adjuvant of micropill is following one or more combinations or other suitable adjuvant, uses with by arbitrary proportion: ethyl cellulose (EC), the polypropylene polysiloxanes, the wax class, Polyethylene Glycol (PEG), stearic acid, Lac, acrylic resin, polyvinyl alcohol, polyvinylpyrrolidone (PVP), methylcellulose, hydroxypropyl cellulose, cellulose propionate, the acrylic resin aqueous dispersion, the pseudo-latex of ethyl cellulose, cellulose acetate-phthalate (CAP) latex, polyphenyl dioctyl phthalate vinyl acetate (PVAP) aqueous dispersion, propylene glycol, glycerol, triacetin, acetyl list monoglyceride, phthalic acid ester, polyoxyethylene sorbitan monoleate, sodium lauryl sulphate, lactose, fructose, sucrose.
(6) get the fine drug powder of (2) gained, add appropriate amount of auxiliary materials, mix homogeneously, drying is pressed into buccal tablet;
Adjuvant is one or more mixture or other suitable adjuvant in the following material, uses with by arbitrary proportion:
Icing Sugar, lactose, mannitol, dextrin, aspartame, stevioside, starch, mucialga of arabic gummy, gelatine size, Mentholum (Herba Menthae essence), Borneolum Syntheticum, citric acid.
(7) get (2) gained fine drug powder, add appropriate amount of auxiliary materials, mix homogeneously is suppressed or is dripped and makes soft capsule;
Adjuvant is one or more mixture or other suitable adjuvant in the following material, uses with by arbitrary proportion:
PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, tween.
Specific embodiments:
The present invention further specifies as follows in conjunction with specific embodiments:
A kind of Chinese medicine preparation of preventing phlegm from forming and stopping coughing, it is that main component is tangerine drop pill or micropill or buccal tablet or the soft capsule of Exocarpium Citri Grandis, Pericarpium Citri Reticulatae, Poria, Semen Armeniacae Amarum, Pericarpium Trichosanthis, Bulbus Fritillariae Thunbergii, Radix Rehmanniae, Radix Ophiopogonis, Gypsum Fibrosum, Rhizoma Pinelliae (processed), Radix Platycodonis, Fructus Perillae (stir-fry), Radix Asteris, Radix Glycyrrhizae, Flos Farfarae.
Cough-relieving is reduced phlegm in Chinese medicine preparation energy of the present invention heat clearing away.Be used for phlegm-heat cough, abundant expectoration, yellow skin is sticky, xerostomia uncomfortable in chest.
The preparation method of Chinese medicine preparation of the present invention is:
(1) medicine constituent and weight consumption thereof are as follows:
Exocarpium Citri Grandis 150g, Pericarpium Citri Reticulatae, Poria, Semen Armeniacae Amarum, Pericarpium Trichosanthis, Bulbus Fritillariae Thunbergii, Radix Rehmanniae, Radix Ophiopogonis, each 100g of Gypsum Fibrosum, Rhizoma Pinelliae (processed), Radix Platycodonis, Fructus Perillae (stir-fry), each 75g of Radix Asteris, Radix Glycyrrhizae, each 50g of Flos Farfarae;
(2) above ten five tastes decoct with water secondary, and each 2 hours, collecting decoction staticly settled 6～8 hours, filter, and filtrate is concentrated into the clear paste that relative density is 1.32～1.34 (70～75 ℃), is dried and crushed into fine drug powder, and is standby;
(3) the Chinese medicine preparation drop pill of preventing phlegm from forming and stopping coughing is tangerine drop pill, its preparation method is: taking polyethylene glycol PEG600060g, stearic acid 10g, Poloxamer188 10g, treat that Polyethylene Glycol PEG6000, stearic acid, Poloxamer188 are heated to the fine drug powder that adds (2) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 80 ℃, at heat-retaining condition by splashing in the liquid paraffin, be condensed into ball, with the drop pill drop of molding to the greatest extent and the erasing liquor paraffin body, cold drying promptly.
(4) the Chinese medicine preparation micropill of transconversion into heat expectorant lung qi dispersing cough-relieving is tangerine micropill, its preparation method is: the fine drug powder of getting (2) gained, with 100g dextrin mix homogeneously, 5%PVP alcohol liquid is binding agent, at first prepare 60 purpose granules and make parent nucleus, be binding agent with 5%PVP alcohol liquid again, add the mixed powder amplification and make 40 purpose micropills.
(5) Chinese medicine preparation of transconversion into heat expectorant lung qi dispersing cough-relieving is the tangerine buccal tablet of buccal tablet, its preparation method is: the fine drug powder of getting (2) gained, add cane sugar powder 30g, abundant mixing, cross 60～80 mesh sieves, add the Herba Menthae essence of 20g starch and 20ml simultaneously with the 20g mucialga of arabic gummy, granulation, granulate, oven dry are pressed into buccal tablet.
(10) the Chinese medicine preparation soft capsule of preventing phlegm from forming and stopping coughing is tangerine soft capsule, its preparation method is to get (2) gained fine drug powder, behind water dissolution, the adding adjuvant is the combination of one or more different proportions in PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, the tween, suppresses or drips and make soft capsule.
Advantage of the present invention is:
Carry, taking convenience, the bioavilability height, controllability and good stability are conducive to improve curative effect.
Claims (3)
1, a kind of Chinese medicine preparation of preventing phlegm from forming and stopping coughing is characterized in that it is that main component is tangerine drop pill or micropill or buccal tablet or the soft capsule of Exocarpium Citri Grandis, Pericarpium Citri Reticulatae, Poria, Semen Armeniacae Amarum, Pericarpium Trichosanthis, Bulbus Fritillariae Thunbergii, Radix Rehmanniae, Radix Ophiopogonis, Gypsum Fibrosum, Rhizoma Pinelliae (processed), Radix Platycodonis, Fructus Perillae (stir-fry), Radix Asteris, Radix Glycyrrhizae, Flos Farfarae.
2, a kind of preparation method of Chinese medicine preparation of preventing phlegm from forming and stopping coughing, it is tangerine drop pill or micropill or buccal tablet or preparation of soft capsule method, it is characterized in that:
(1) medicine constituent and percentage by weight thereof are as follows:
Exocarpium Citri Grandis 8～15%, Pericarpium Citri Reticulatae, Poria, Semen Armeniacae Amarum, Pericarpium Trichosanthis, Bulbus Fritillariae Thunbergii, Radix Rehmanniae, Radix Ophiopogonis, Gypsum Fibrosum each 5～10%, Rhizoma Pinelliae (processed), Radix Platycodonis, Fructus Perillae (stir-frys), Radix Asteris each 2～8%, Radix Glycyrrhizae, Flos Farfarae respectively 1～5%;
(2) get above ten five tastes, decoct with water 1～3 time, each 1～3 hour, collecting decoction staticly settled 4～10 hours, filtered, and filtrate is concentrated into the clear paste that relative density is 1.30～1.40 (60～80 ℃), and drying is ground into fine drug powder, and is standby;
(3) get the fine drug powder of (2) gained, after the adding appropriate amount of auxiliary materials, be made into drop pill or micropill or buccal tablet or soft capsule;
The preparation method of its drop pill is: with one or more or other suitable adjuvant of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188, use with by arbitrary proportion, be heated to the fine drug powder that adds (2) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70～100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, with the drop pill drop of molding to the greatest extent and remove coolant, dry coationg promptly;
The preparation method of micropill is: get the hybrid medicine fine powder of (2) gained, add appropriate amount of auxiliary materials after, mix homogeneously is granulated, coating or coating are not made the micropill of diameter less than 2.5mm;
The adjuvant of micropill is following one or more combinations or other suitable adjuvant, uses with by arbitrary proportion: ethyl cellulose (EC), the polypropylene polysiloxanes, the wax class, Polyethylene Glycol (PEG), stearic acid, Lac, acrylic resin, polyvinyl alcohol, polyvinylpyrrolidone (PVP), methylcellulose, hydroxypropyl cellulose, cellulose propionate, the acrylic resin aqueous dispersion, the pseudo-latex of ethyl cellulose, cellulose acetate-phthalate (CAP) latex, polyphenyl dioctyl phthalate vinyl acetate (PVAP) aqueous dispersion, propylene glycol, glycerol, triacetin, acetyl list monoglyceride, phthalic acid ester, polyoxyethylene sorbitan monoleate, sodium lauryl sulphate, lactose, fructose, sucrose;
The preparation method of its buccal tablet is: gets the fine drug powder of (2) gained, adds appropriate amount of auxiliary materials, and mix homogeneously, drying is pressed into buccal tablet;
Adjuvant is one or more mixture or other suitable adjuvant in the following material, uses with by arbitrary proportion:
Icing Sugar, lactose, mannitol, dextrin, aspartame, stevioside, starch, mucialga of arabic gummy, gelatine size, Mentholum (Herba Menthae essence), Borneolum Syntheticum, citric acid;
Its preparation of soft capsule method is: get (2) gained fine drug powder, add appropriate amount of auxiliary materials, mix homogeneously is suppressed or is dripped and makes soft capsule;
Adjuvant is one or more mixture or other suitable adjuvant in the following material, uses with by arbitrary proportion:
PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, tween.
3, the preparation method of the Chinese medicine preparation of a kind of preventing phlegm from forming and stopping coughing according to claim 2 is characterized in that the optimum weight percentage ratio of its main constituent is:
Exocarpium Citri Grandis 11%, Pericarpium Citri Reticulatae, Poria, Semen Armeniacae Amarum, Pericarpium Trichosanthis, Bulbus Fritillariae Thunbergii, Radix Rehmanniae, Radix Ophiopogonis, Gypsum Fibrosum each 7.4%, Rhizoma Pinelliae (processed), Radix Platycodonis, Fructus Perillae (stir-frys), Radix Asteris each 5.6%, Radix Glycyrrhizae, Flos Farfarae respectively 3.7%.
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| CN 200510031943 CN1733204A (en) | 2005-07-29 | 2005-07-29 | Chinese traditional medicine preparation for resolving phlegm and relieving cough and process for preparing the same |
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| CN 200510031943 CN1733204A (en) | 2005-07-29 | 2005-07-29 | Chinese traditional medicine preparation for resolving phlegm and relieving cough and process for preparing the same |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101209341B (en) * | 2006-12-30 | 2011-05-18 | 杨文龙 | Chinese medicinal preparation, preparation and detection method thereof |
| CN102370875A (en) * | 2010-08-17 | 2012-03-14 | 北京亚东生物制药有限公司 | Effervescing agent for relieving cough and reducing sputum and preparation method thereof |
| CN102406032A (en) * | 2011-12-01 | 2012-04-11 | 广州潘高寿药业股份有限公司 | Throat-smoothing drop containing traditional Chinese medicine extractives |
| CN102657793A (en) * | 2012-04-26 | 2012-09-12 | 修相成 | Chinese medicament for treating secondary pulmonary infection and preparation method thereof |
| CN103071005A (en) * | 2013-01-29 | 2013-05-01 | 长治县国药居大药房 | Medicine for treating infantile cough |
| CN103222642A (en) * | 2013-03-27 | 2013-07-31 | 蚌埠市丰牧牛羊肉制品有限责任公司 | Oat dragon tongue leaf konjak dried beef and preparation method thereof |
| CN103656579A (en) * | 2013-12-11 | 2014-03-26 | 山东中大药业有限公司 | Traditional Chinese medicine composition for relieving cough |
-
2005
- 2005-07-29 CN CN 200510031943 patent/CN1733204A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101209341B (en) * | 2006-12-30 | 2011-05-18 | 杨文龙 | Chinese medicinal preparation, preparation and detection method thereof |
| CN102370875A (en) * | 2010-08-17 | 2012-03-14 | 北京亚东生物制药有限公司 | Effervescing agent for relieving cough and reducing sputum and preparation method thereof |
| CN102370875B (en) * | 2010-08-17 | 2014-03-26 | 北京亚东生物制药有限公司 | Effervescing agent for relieving cough and reducing sputum and preparation method thereof |
| CN102406032A (en) * | 2011-12-01 | 2012-04-11 | 广州潘高寿药业股份有限公司 | Throat-smoothing drop containing traditional Chinese medicine extractives |
| CN102406032B (en) * | 2011-12-01 | 2012-12-12 | 广州白云山潘高寿药业股份有限公司 | Throat-smoothing drop containing traditional Chinese medicine extractives |
| CN102657793A (en) * | 2012-04-26 | 2012-09-12 | 修相成 | Chinese medicament for treating secondary pulmonary infection and preparation method thereof |
| CN103071005A (en) * | 2013-01-29 | 2013-05-01 | 长治县国药居大药房 | Medicine for treating infantile cough |
| CN103222642A (en) * | 2013-03-27 | 2013-07-31 | 蚌埠市丰牧牛羊肉制品有限责任公司 | Oat dragon tongue leaf konjak dried beef and preparation method thereof |
| CN103656579A (en) * | 2013-12-11 | 2014-03-26 | 山东中大药业有限公司 | Traditional Chinese medicine composition for relieving cough |
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