CN1709367A - Chinese medicine formulation for treating dysentery and enteritis, and its preparing method - Google Patents
Chinese medicine formulation for treating dysentery and enteritis, and its preparing method Download PDFInfo
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- CN1709367A CN1709367A CNA2005100318176A CN200510031817A CN1709367A CN 1709367 A CN1709367 A CN 1709367A CN A2005100318176 A CNA2005100318176 A CN A2005100318176A CN 200510031817 A CN200510031817 A CN 200510031817A CN 1709367 A CN1709367 A CN 1709367A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The present invention discloses a Chinese medicine preparation for curing the diseases of dysentery and enteritis and its preparation method. Said Chinese medicine preparation can be made into dripping pills or micropills or dispersing tablet or granules, and is made up by using the Chinese medicinal materials of coptis root (mix-fried with evodia fruit) and saussurea root as main raw material. Said invention also provides the concrete steps of its preparation method. Its bioavailability is high and quality controllability and strability are good, so that its therapeutic effect can be raised.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, relate in particular to a kind of Chinese medicine preparation for the treatment of dysentery, enteritis and preparation method thereof.
Background technology:
Drop pill in the Chinese medicine preparation or micropill or dispersible tablet or granule, change dosage form and manage as new drug research according to the relevant laws and regulations of China's drug control as a kind of pharmaceutical dosage form.The existing dosage form of this product is a tablet, has listed the state-promulgated pharmacopoeia standard in.
The technology features of the Chinese medicine preparation xianglian tablet of existing treatment dysentery, enteritis is to get Radix Aucklandiae distillating extracting oil, collects volatile oil, and decocting liquid filters, and is concentrated into the thick paste shape, and drying is ground into fine powder; Rhizoma Coptidis is used ethanol extraction three times, and merge extractive liquid, reclaims ethanol and also is condensed into the thick paste shape, and drying is ground into fine powder.Merge above-mentioned two kinds of fine powders, add right amount of auxiliary materials, mixing is made granule, drying, and spray adds volatile oil of Radix Aucklandiae, mixing, compacting is in blocks, sugar coating or film-coat, promptly.
There is long, shortcoming such as bioavailability is low, inherent quality is wayward disintegration in the Chinese medicine preparation xianglian tablet of existing treatment dysentery, enteritis.
Summary of the invention:
The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of dysentery, enteritis and preparation method thereof, overcome the above-mentioned drawback of prior art, improve the quality and the curative effect of product, satisfy the needs of medical treatment better.
The objective of the invention is to be achieved through the following technical solutions.
The Chinese medicine preparation of treatment dysentery, enteritis, it is that main component is that the perfume (or spice) of Rhizoma Coptidis (Fructus Evodiae system), the Radix Aucklandiae connects drop pill or micropill or dispersible tablet or granule.
Its preparation method is:
(1) medicine constituent and percentage by weight thereof are as follows:
Rhizoma Coptidis (Fructus Evodiae system) 70～90%, the Radix Aucklandiae 10～30%;
Medicine constituent optimum weight percentage ratio is:
Rhizoma Coptidis (Fructus Evodiae system) 80%, the Radix Aucklandiae 20%;
(2) get the Radix Aucklandiae and extract volatile oil, collect volatile oil with steam distillation, standby; Decocting liquid filters, and is concentrated into the thick paste shape, and drying is ground into fine powder, and is standby;
(3) get Rhizoma Coptidis and extract 2～4 times in 70～85 ℃ with 60～80% ethanol, each 1～3 hour, merge extractive liquid, reclaimed ethanol and also is concentrated into the thick paste shape, and drying is ground into fine powder, and is standby;
(4) fine powder of merging (2) and (3) gained, mixing gets the hybrid medicine fine powder, and is standby;
(5) get the hybrid medicine fine powder of (4) gained, spray into the volatile oil of (2) gained, get hybrid medicine, standby;
(6) with one or more or other suitable adjuvant of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188, use with by arbitrary proportion, be heated to the hybrid medicine that adds (5) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70-100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, with the drop pill drop of molding to the greatest extent and remove coolant, dry coationg promptly;
(7) get the hybrid medicine fine powder of (4) gained, add an amount of adjuvant, mix homogeneously is granulated, and sprays into the volatile oil of (2) gained, and coating or coating are not made the micropill of diameter less than 2.5mm;
Adjuvant is one or more combinations or other suitable adjuvant in the following material, uses with by arbitrary proportion: ethyl cellulose (EC), the polypropylene polysiloxanes, the wax class, Polyethylene Glycol (PEG), stearic acid, Lac, acrylic resin, polyvinyl alcohol, polyvinylpyrrolidone (PVP), methylcellulose, hydroxypropyl cellulose, cellulose propionate, the acrylic resin aqueous dispersion, the pseudo-latex of ethyl cellulose, cellulose acetate-phthalate (CAP) latex, polyphenyl dioctyl phthalate vinyl acetate (PVAP) aqueous dispersion, propylene glycol, glycerol, triacetin, acetyl list monoglyceride, phthalic acid ester, polyoxyethylene sorbitan monoleate, sodium lauryl sulphate, lactose, fructose, sucrose;
(8) get (4) gained hybrid medicine fine powder, add appropriate amount of auxiliary materials, mix homogeneously behind granulation, drying, the granulate, sprays into the volatile oil of (2) gained, and mixing is pressed into dispersible tablet;
Adjuvant is one or more mixture or other suitable adjuvant in the following material, uses with by arbitrary proportion: low-substituted hydroxypropyl cellulose, dimension splash form sediment 5000, polyvinylpolypyrrolidone 1NF-10, polyethylene glycols, polyvinylpyrrolidone class, methylcellulose, ethyl cellulose, hydroxypropyl emthylcellulose, cellulose acetate-phthalate, hydroxypropyl methylcellulose phthalate, hydroxymethyl ethyl cellulose, microcrystalline Cellulose, citric acid, cholic acid, fumaric acid, succinic acid, tartaric acid, colloidality silicon dioxide, magnesium stearate, Pulvis Talci;
(9) get (4) gained hybrid medicine fine powder, add appropriate amount of auxiliary materials, mixing is granulated, drying, and granulate sprays into the volatile oil of (2) gained, and coating or coating are not promptly made granule;
Adjuvant is one or more mixture or other suitable adjuvant in the following material, uses with by arbitrary proportion: stevioside, protein sugar, xylitol, high fructose, cyclamate, beta-schardinger dextrin-, dextrin, lactose, saccharin sodium, ethanol, water.
Specific embodiments:
The present invention further specifies as follows in conjunction with specific embodiments:
A kind of Chinese medicine preparation for the treatment of dysentery, enteritis, it is that main component is that the perfume (or spice) of Rhizoma Coptidis (Fructus Evodiae system), the Radix Aucklandiae connects drop pill or micropill or dispersible tablet or granule.
Chinese medicine preparation of the present invention is mainly used in the dysentery due to the damp-heat in the large intestine, and disease is seen stool containing pus and blood, tenesmus, heating stomachache; Enteritis, bacillary dysentery are seen above-mentioned patient.
The preparation method of Chinese medicine preparation of the present invention is:
(1) medicine constituent and weight consumption thereof are as follows:
Rhizoma Coptidis 800g, Radix Aucklandiae 200g;
(2) get the Radix Aucklandiae and extract volatile oil, collect volatile oil with steam distillation, standby; Decocting liquid filters, and is concentrated into the thick paste shape, and drying is ground into fine powder, and is standby;
(3) get Rhizoma Coptidis and extract 3 times in 75～80 ℃ with 70% ethanol, 2 hours for the first time, second and third time each 1 hour, merge extractive liquid, reclaims ethanol and also is concentrated into the thick paste shape, and drying is ground into fine powder, and is standby;
(4) fine powder of merging (2) and (3) gained, mixing gets the hybrid medicine fine powder, and is standby;
(5) get the hybrid medicine fine powder of (4) gained, spray into the volatile oil of (2) gained, get hybrid medicine, standby;
(6) the Chinese medicine preparation drop pill of treatment dysentery, enteritis is the fragrant drop pill that connects, its preparation method is: taking polyethylene glycol PEG6000100g, stearic acid 20g, Poloxamer188 10g, treat that Polyethylene Glycol PEG6000, stearic acid, Poloxamer188 are heated to the hybrid medicine that adds (5) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 80 ℃, at heat-retaining condition by splashing in the liquid paraffin, be condensed into ball, with the drop pill drop of molding to the greatest extent and the erasing liquor paraffin body, cold drying promptly.
(7) the Chinese medicine preparation micropill of treatment dysentery, enteritis is the fragrant micropill that connects, its preparation method is: hybrid medicine fine powder and the 180g dextrin mix homogeneously of getting (4) gained, 5%PVP alcohol liquid is binding agent, at first prepare 60 purpose granules and make parent nucleus, be binding agent with 5%PVP alcohol liquid again, add the mixed powder amplification and make 40 purpose micropills, spray into the volatile oil of (2) gained, promptly.
(8) the Chinese medicine preparation granule of treatment dysentery, enteritis is the fragrant granule that connects, its preparation method is: get (4) gained hybrid medicine fine powder, add B-cyclodextrin 30g, add oligomeric lactose 80g and fully stir, mixing, spray drying adds the 1.5g stevioside, granulates, dry, behind the granulate, spray into the volatile oil of (2) gained, promptly.
(9) the Chinese medicine preparation dispersible tablet of treatment dysentery, enteritis is the fragrant dispersible tablet that connects, its preparation method is: get (4) obtained hybrid medicine fine powder, add the swollen shallow lake P5000 80g of dimension, polyvinylpolypyrrolidone INF-10 30g, PEG600020g and PEG400020g cross 100 mesh sieves, mix homogeneously is crossed 80 mesh sieve secondaries, adds silicon dioxide, the magnesium stearate mix homogeneously of 100 mesh sieves, cross 80 mesh sieve secondaries, spray into the volatile oil of (2) gained, airtight moistening 12 hours, tabletting is promptly.
Advantage of the present invention is:
The bioavilability height, controllability and good stability are conducive to improve curative effect.
Claims (3)
1, a kind of Chinese medicine preparation for the treatment of dysentery, enteritis is characterized in that it is that main component is that the perfume (or spice) of Rhizoma Coptidis (Fructus Evodiae system), the Radix Aucklandiae connects drop pill or micropill or dispersible tablet or granule.
2, a kind of preparation method for the treatment of the Chinese medicine preparation of dysentery, enteritis, it is fragrant drop pill or micropill or dispersible tablet or the particulate preparation method of connecting, and it is characterized in that:
(1) medicine constituent and percentage by weight thereof are as follows:
Rhizoma Coptidis (Fructus Evodiae system) 70～90%, the Radix Aucklandiae 10～30%;
(2) get the Radix Aucklandiae and extract volatile oil, collect volatile oil with steam distillation, standby; Decocting liquid filters, and is concentrated into the thick paste shape, and drying is ground into fine powder, and is standby;
(3) get Rhizoma Coptidis and extract 2～4 times in 70～85 ℃ with 60～80% ethanol, each 1～3 hour, merge extractive liquid, reclaimed ethanol and also is concentrated into the thick paste shape, and drying is ground into fine powder, and is standby;
(4) fine powder of merging (2) and (3) gained, mixing gets the hybrid medicine fine powder, and is standby;
(5) get the hybrid medicine fine powder of (4) gained, spray into the volatile oil of (2) gained, mixing gets hybrid medicine, after the adding appropriate amount of auxiliary materials, is made into drop pill or micropill or granule or dispersible tablet again;
The preparation method of its drop pill is: with one or more or other suitable adjuvant of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188, use with by arbitrary proportion, be heated to the hybrid medicine that adds (5) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70-100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, with the drop pill drop of molding to the greatest extent and remove coolant, dry coationg promptly;
The preparation method of its micropill is: get the hybrid medicine fine powder of (4) gained, add an amount of adjuvant, mix homogeneously is granulated, and sprays into the volatile oil of (2) gained, and coating or coating are not made the micropill of diameter less than 2.5mm;
Adjuvant is one or more combinations or other suitable adjuvant in the following material, uses with by arbitrary proportion: ethyl cellulose (EC), the polypropylene polysiloxanes, the wax class, Polyethylene Glycol (PEG), stearic acid, Lac, acrylic resin, polyvinyl alcohol, polyvinylpyrrolidone (PVP), methylcellulose, hydroxypropyl cellulose, cellulose propionate, the acrylic resin aqueous dispersion, the pseudo-latex of ethyl cellulose, cellulose acetate-phthalate (CAP) latex, polyphenyl dioctyl phthalate vinyl acetate (PVAP) aqueous dispersion, propylene glycol, glycerol, triacetin, acetyl list monoglyceride, phthalic acid ester, polyoxyethylene sorbitan monoleate, sodium lauryl sulphate, lactose, fructose, sucrose;
The preparation method of its dispersible tablet is: get (4) gained hybrid medicine fine powder, add appropriate amount of auxiliary materials, mix homogeneously behind granulation, drying, the granulate, sprays into the volatile oil of (2) gained, and mixing is pressed into dispersible tablet;
Adjuvant is one or more mixture or other suitable adjuvant in the following material, uses with by arbitrary proportion: low-substituted hydroxypropyl cellulose, dimension splash form sediment 5000, polyvinylpolypyrrolidone 1NF-10, polyethylene glycols, polyvinylpyrrolidone class, methylcellulose, ethyl cellulose, hydroxypropyl emthylcellulose, cellulose acetate-phthalate, hydroxypropyl methylcellulose phthalate, hydroxymethyl ethyl cellulose, microcrystalline Cellulose, citric acid, cholic acid, fumaric acid, succinic acid, tartaric acid, colloidality silicon dioxide, magnesium stearate, Pulvis Talci;
Its particulate preparation method is: get (4) gained hybrid medicine fine powder, add appropriate amount of auxiliary materials, mixing is granulated, drying, and granulate sprays into the volatile oil of (2) gained, and coating or coating are not made granule, promptly;
Adjuvant is one or more mixture or other suitable adjuvant in the following material, uses with by arbitrary proportion: stevioside, protein sugar, xylitol, high fructose, cyclamate, beta-schardinger dextrin-, dextrin, lactose, saccharin sodium, ethanol, water.
3, a kind of preparation method for the treatment of the Chinese medicine preparation of dysentery, enteritis according to claim 2 is characterized in that the optimum weight percentage ratio of its main constituent is:
Rhizoma Coptidis (Fructus Evodiae system) 80%, the Radix Aucklandiae 20%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005100318176A CN1709367A (en) | 2005-07-06 | 2005-07-06 | Chinese medicine formulation for treating dysentery and enteritis, and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2005100318176A CN1709367A (en) | 2005-07-06 | 2005-07-06 | Chinese medicine formulation for treating dysentery and enteritis, and its preparing method |
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| CN1709367A true CN1709367A (en) | 2005-12-21 |
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| CNA2005100318176A Pending CN1709367A (en) | 2005-07-06 | 2005-07-06 | Chinese medicine formulation for treating dysentery and enteritis, and its preparing method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101019938B (en) * | 2006-12-06 | 2010-05-19 | 武建军 | Chinese medicine for treating enteritis and colitis and its preparation method |
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- 2005-07-06 CN CNA2005100318176A patent/CN1709367A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101019938B (en) * | 2006-12-06 | 2010-05-19 | 武建军 | Chinese medicine for treating enteritis and colitis and its preparation method |
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