CN1739579A - Chinese medicine prepn for removing blood stasis and activating blood circulation to dissipate blood stasis and its prepn process - Google Patents
Chinese medicine prepn for removing blood stasis and activating blood circulation to dissipate blood stasis and its prepn process Download PDFInfo
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- CN1739579A CN1739579A CNA2005100321198A CN200510032119A CN1739579A CN 1739579 A CN1739579 A CN 1739579A CN A2005100321198 A CNA2005100321198 A CN A2005100321198A CN 200510032119 A CN200510032119 A CN 200510032119A CN 1739579 A CN1739579 A CN 1739579A
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Abstract
The present invention discloses one kind of Chinese medicine preparation for removing blood stasis and activating blood circulation to dissipate blood stasis and its preparation process. The Chinese medicine preparation has leech as main component and may be prepared into dripping pill, soft capsule, dispersed tablet, micro pill or capsule. The preparation process includes crushing leech into coarse powder, reflux extraction with anhydrous methanol, decompression concentrating the extracted liquid to no methanol, dissolving in distilled water, extraction with n-hexane, ethyl acetate and n-butane, concentrating water solution, crushing, adding supplementary material, and further preparing into dripping pill, soft capsule, dispersed tablet, micro pill or capsule. The present invention has the advantages of high bioavailability, high controllability, high stability, high curative effect, etc.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, relate in particular to Chinese medicine preparation of a kind of removing blood stasis, promoting blood circulation to remove blood stasis and preparation method thereof.
Background technology:
Prescription is a capsule for the existing dosage form of the blood circulation and channel invigorating of Hirudo by retrieval, has listed Ministry of Public Health new drug become a full member the 13 of standard and " National Drug Administration's new drug become a full member standard " the 17 in.There is not the relevant patent of prescription through patent retrieval for the blood circulation and channel invigorating of Hirudo.
Drop pill in the Chinese medicine preparation or soft capsule or dispersible tablet or micropill or pellet capsule, change dosage form or technology and manage as new drug research according to the relevant laws and regulations of China's drug control as a kind of pharmaceutical dosage form.Drop pill has that surface area is big, and dissolution rate is fast, and the gastrointestinal irritation effect is little, advantages such as taking convenience; It is good that soft capsule has bioavailability, sealing, safety, and medicament is stable, and dosage is accurate, and good looking appearance carries with easy to use; Dispersible tablet has good dispersing state, and disintegration time is short, and the medicine stripping is rapid, absorbs soon, and the bioavailability height, can be swallowed, chew to contain and suck or with taking after the aqueous dispersion, especially be fit to old man and child taking convenience; Micropill has at the gastrointestinal tract distribution area big, the bioavailability height, and zest is little, because particle diameter is little, is subjected to digestive tract to carry the food rhythm and pace of moving things to influence little (close as pylorus etc.), good fluidity, size evenly is easy to handle (as coating, divided dose).
There are shortcomings such as easy moisture absorption, produce effects is slow, bioavailability is low in existing blood circulation and channel invigorating capsule.
Summary of the invention:
The purpose of this invention is to provide Chinese medicine preparation of a kind of removing blood stasis, promoting blood circulation to remove blood stasis and preparation method thereof, overcome the drawback of prior art, improve the quality and the curative effect of product, satisfy the needs of medical treatment better.
The objective of the invention is to be achieved through the following technical solutions.
The Chinese medicine preparation of a kind of removing blood stasis, promoting blood circulation to remove blood stasis, it is that main constituent is blood circulation and channel invigorating drop pill or soft capsule or dispersible tablet or micropill or the pellet capsule of Hirudo.
Its preparation method is:
(1) the main constituent of medicine is Hirudo;
(2) the water intaking trematodiasis is ground into coarse powder, uses absolute methanol reflux, extract, 2-4 time, and merge extractive liquid, is evaporated to no methanol, and normal hexane, ethyl acetate, n-butanol extraction are used in the adding distil water dissolving respectively, and the aqueous solution partial concentration is pulverized, and it is standby to get fine powder;
(3) after the fine powder of getting (2) gained added suitable adjuvant, mixing was made drop pill or soft capsule or dispersible tablet or micropill or pellet capsule;
The preparation method of its drop pill is: with one or more of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188 or other suitable adjuvant, use with by arbitrary proportion, be heated to the fine powder that adds (2) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70-100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, coolant is use up and removed to the drop pill drop of molding, dry, coating or coating not, promptly;
Its preparation of soft capsule method is: get the fine powder of (2) gained, add suitable adjuvant, mix homogeneously is suppressed or is dripped and makes soft capsule;
Adjuvant is one or more combinations or other suitable adjuvant of following material, uses with by arbitrary proportion: PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, tween;
The preparation method of its dispersible tablet is: get the fine powder of (2) gained, add appropriate amount of auxiliary materials, mix homogeneously is granulated, drying, and granulate is pressed into dispersible tablet;
Adjuvant is one or more mixture or other suitable adjuvant in the following material, uses with by arbitrary proportion: low-substituted hydroxypropyl cellulose, dimension splash form sediment 5000, polyvinylpolypyrrolidone 1NF-10, polyethylene glycols, polyvinylpyrrolidone class, methylcellulose, ethyl cellulose, hydroxypropyl emthylcellulose, cellulose acetate-phthalate, hydroxypropyl methylcellulose phthalate, hydroxymethyl ethyl cellulose, microcrystalline Cellulose, citric acid, cholic acid, fumaric acid, succinic acid, tartaric acid, colloidality silicon dioxide, magnesium stearate, Pulvis Talci;
The preparation method of its micropill or pellet capsule is: get the fine powder of (2) gained, add an amount of adjuvant, mix homogeneously is granulated, and coating or coating are not made the micropill of diameter less than 2.5mm; Maybe, incapsulate, promptly get pellet capsule the micropill that makes;
Micropill or pellet capsule adjuvant are following one or more combinations or other suitable adjuvant, use with by arbitrary proportion: ethyl cellulose (EC), the polypropylene polysiloxanes, the wax class, Polyethylene Glycol (PEG), stearic acid, Lac, acrylic resin, polyvinyl alcohol, polyvinylpyrrolidone (PVP), methylcellulose, hydroxypropyl cellulose, cellulose propionate, the acrylic resin aqueous dispersion, the pseudo-latex of ethyl cellulose, cellulose acetate-phthalate (CAP) latex, polyphenyl dioctyl phthalate vinyl acetate (PVAP) aqueous dispersion, propylene glycol, glycerol, triacetin, acetyl list monoglyceride, phthalic acid ester, polyoxyethylene sorbitan monoleate, sodium lauryl sulphate, lactose, fructose, sucrose.
Specific embodiments:
The present invention further specifies in conjunction with specific embodiments, can be for reference, but do not limit the scope of the invention:
The Chinese medicine preparation of a kind of removing blood stasis, promoting blood circulation to remove blood stasis, it is that main constituent is blood circulation and channel invigorating drop pill or soft capsule or dispersible tablet or micropill or the pellet capsule of Hirudo.
Chinese medicine preparation of the present invention has removing blood stasis, and promoting blood circulation to remove blood stasis stimulates the menstrual flow, coronary circulation-promoting pain-relieving.Be mainly used in the lump in the abdomen mass in the abdomen, the blood stasis amenorrhea, traumatic injury and hyperlipemia, seeing has the expectorant stasis of blood cohesion person that belongs to such as dizzy, uncomfortable in chest, pained, fat.
The preparation method of the Chinese medicine preparation blood circulation and channel invigorating drop pill of a kind of removing blood stasis of the present invention, promoting blood circulation to remove blood stasis or soft capsule or dispersible tablet or micropill or pellet capsule is:
(1) the main constituent of medicine is Hirudo;
(2) water intaking trematodiasis 70g is ground into coarse powder, with absolute methanol reflux, extract, 3 times, add 8 times of amounts for the first time, add 6 times of amounts for the second time, add 4 times of amounts for the third time, merge extractive liquid, is evaporated to no methanol, the adding distil water dissolving, use normal hexane, ethyl acetate, n-butanol extraction respectively, the aqueous solution partial concentration is pulverized, and it is standby to get fine powder;
(3) the Chinese medicine preparation drop pill of a kind of removing blood stasis, promoting blood circulation to remove blood stasis is the blood circulation and channel invigorating drop pill, its preparation method is a fine powder of getting (2) gained, Polyethylene Glycol PEG6000 105g, stearic acid 36g, Poloxamer188 20g, treat to add above-mentioned fine powder after Polyethylene Glycol PEG6000, stearic acid, Poloxamer188 are heated to whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 80 ℃, at heat-retaining condition by splashing in the liquid paraffin, be condensed into ball, with the drop pill drop of molding to the greatest extent and the erasing liquor paraffin body, cold drying promptly.
(4) the Chinese medicine preparation soft capsule of a kind of removing blood stasis, promoting blood circulation to remove blood stasis is the blood circulation and channel invigorating soft capsule, its preparation method is a fine powder of getting (2) gained, behind water dissolution, the adding adjuvant is the combination of one or more different proportions in PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, the tween, suppresses or drips and make soft capsule.
(5) the Chinese medicine preparation dispersible tablet of a kind of removing blood stasis, promoting blood circulation to remove blood stasis is the blood circulation and channel invigorating dispersible tablet, its preparation method is a fine powder of getting (2) gained, adds cross-linking polyethylene pyrrolidone 50g, low-substituted hydroxypropyl cellulose 20g, microcrystalline Cellulose 120g, mix homogeneously, the secondary that sieves, the micropowder silica gel of adding 0.5%, mix homogeneously, cross 80 mesh sieve secondaries, tabletting promptly gets dispersible tablet.
(6) the Chinese medicine preparation micropill of a kind of removing blood stasis, promoting blood circulation to remove blood stasis or pellet capsule are blood circulation and channel invigorating micropill or pellet capsule, its preparation method is a fine powder of getting (2) gained, with 120g dextrin mix homogeneously, 5%PVP alcohol liquid is binding agent, at first prepare 60 purpose granules and make parent nucleus, be binding agent with 5%PVP alcohol liquid again, add the mixed powder amplification and make 40 purpose micropills, promptly.
(7) the Chinese medicine preparation micropill of a kind of removing blood stasis, promoting blood circulation to remove blood stasis or pellet capsule are blood circulation and channel invigorating micropill or pellet capsule, its preparation method is a fine powder of getting (2) gained, with 120g dextrin mix homogeneously, 5%PVP alcohol liquid is binding agent, at first preparing 60 purpose granules and make parent nucleus, is binding agent with 5%PVP alcohol liquid again, adds the mixed powder amplification and makes 40 purpose micropills, incapsulate, promptly get pellet capsule.
You point of the present invention is:
Carry with easy to use, be difficult for the moisture absorption, the bioavilability height, controllability and good stability, You is beneficial to raising Curative effect.
Claims (3)
1, the Chinese medicine preparation of a kind of removing blood stasis, promoting blood circulation to remove blood stasis is characterized in that it is that main constituent is blood circulation and channel invigorating drop pill or soft capsule or dispersible tablet or micropill or the pellet capsule of Hirudo.
2, the preparation method of the Chinese medicine preparation of a kind of removing blood stasis, promoting blood circulation to remove blood stasis, it is the preparation method of blood circulation and channel invigorating drop pill or soft capsule or dispersible tablet or micropill or pellet capsule, it is characterized in that:
(1) the main constituent of medicine is Hirudo;
(2) the water intaking trematodiasis is ground into coarse powder, uses absolute methanol reflux, extract, 2-4 time, and merge extractive liquid, is evaporated to no methanol, and normal hexane, ethyl acetate, n-butanol extraction are used in the adding distil water dissolving respectively, and the aqueous solution partial concentration is pulverized, and it is standby to get fine powder;
(3) after the fine powder of getting (2) gained added suitable adjuvant, mixing was made drop pill or soft capsule or dispersible tablet or micropill or pellet capsule;
The preparation method of its drop pill is: with one or more of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188 or other suitable adjuvant, use with by arbitrary proportion, be heated to the fine powder that adds (2) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70-100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, coolant is use up and removed to the drop pill drop of molding, dry, coating or coating not, promptly;
Its preparation of soft capsule method is: get the fine powder of (2) gained, add suitable adjuvant, mix homogeneously is suppressed or is dripped and makes soft capsule;
Adjuvant is one or more combinations or other suitable adjuvant of following material, uses with by arbitrary proportion: PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, tween;
The preparation method of its dispersible tablet is: get the fine powder of (2) gained, add appropriate amount of auxiliary materials, mix homogeneously is granulated, drying, and granulate is pressed into dispersible tablet;
Adjuvant is one or more mixture or other suitable adjuvant in the following material, uses with by arbitrary proportion: low-substituted hydroxypropyl cellulose, dimension splash form sediment 5000, polyvinylpolypyrrolidone 1NF-10, polyethylene glycols, polyvinylpyrrolidone class, methylcellulose, ethyl cellulose, hydroxypropyl emthylcellulose, cellulose acetate-phthalate, hydroxypropyl methylcellulose phthalate, hydroxymethyl ethyl cellulose, microcrystalline Cellulose, citric acid, cholic acid, fumaric acid, succinic acid, tartaric acid, colloidality silicon dioxide, magnesium stearate, Pulvis Talci;
The preparation method of its micropill or pellet capsule is: get the fine powder of (2) gained, add an amount of adjuvant, mix homogeneously is granulated, and coating or coating are not made the micropill of diameter less than 2.5mm; Maybe, incapsulate, promptly get pellet capsule the micropill that makes;
Micropill or pellet capsule adjuvant are following one or more combinations or other suitable adjuvant, use with by arbitrary proportion: ethyl cellulose (EC), the polypropylene polysiloxanes, the wax class, Polyethylene Glycol (PEG), stearic acid, Lac, acrylic resin, polyvinyl alcohol, polyvinylpyrrolidone (PVP), methylcellulose, hydroxypropyl cellulose, cellulose propionate, the acrylic resin aqueous dispersion, the pseudo-latex of ethyl cellulose, cellulose acetate-phthalate (CAP) latex, polyphenyl dioctyl phthalate vinyl acetate (PVAP) aqueous dispersion, propylene glycol, glycerol, triacetin, acetyl list monoglyceride, phthalic acid ester, polyoxyethylene sorbitan monoleate, sodium lauryl sulphate, lactose, fructose, sucrose.
3, a kind of removing blood stasis according to claim 2, promoting blood circulation to remove blood stasis preparation method, it is characterized in that by adding suitable adjuvant, other any pharmaceutically useful dosage forms be can make, sheet (plain sheet, coated tablet, Film coated tablets, enteric coatel tablets, effervescent tablet, slow-release tablet, fast-release tablet), capsule, enteric coated capsule, slow, controlled release capsule, ball, granule, effervescent granule, oral liquid, injection etc. comprised.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005100321198A CN1739579A (en) | 2005-09-06 | 2005-09-06 | Chinese medicine prepn for removing blood stasis and activating blood circulation to dissipate blood stasis and its prepn process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005100321198A CN1739579A (en) | 2005-09-06 | 2005-09-06 | Chinese medicine prepn for removing blood stasis and activating blood circulation to dissipate blood stasis and its prepn process |
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| Publication Number | Publication Date |
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| CN1739579A true CN1739579A (en) | 2006-03-01 |
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| CNA2005100321198A Pending CN1739579A (en) | 2005-09-06 | 2005-09-06 | Chinese medicine prepn for removing blood stasis and activating blood circulation to dissipate blood stasis and its prepn process |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106174260A (en) * | 2016-07-11 | 2016-12-07 | 来鑫（厦门）生物科技有限公司 | A kind of black Bulbus Allii water extract purposes in promoting intestinal emptying and containing the food of black Bulbus Allii water extract and medicine |
| CN107397731A (en) * | 2017-07-25 | 2017-11-28 | 重庆多普泰制药股份有限公司 | A kind of Maixuekang plain piece, enteric coated tablet and preparation method thereof |
| CN107960287A (en) * | 2017-11-24 | 2018-04-27 | 恭城福茂生油茶文化产业发展有限公司 | A kind of high-yield planting method of glutinous rice |
-
2005
- 2005-09-06 CN CNA2005100321198A patent/CN1739579A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106174260A (en) * | 2016-07-11 | 2016-12-07 | 来鑫（厦门）生物科技有限公司 | A kind of black Bulbus Allii water extract purposes in promoting intestinal emptying and containing the food of black Bulbus Allii water extract and medicine |
| CN107397731A (en) * | 2017-07-25 | 2017-11-28 | 重庆多普泰制药股份有限公司 | A kind of Maixuekang plain piece, enteric coated tablet and preparation method thereof |
| CN107960287A (en) * | 2017-11-24 | 2018-04-27 | 恭城福茂生油茶文化产业发展有限公司 | A kind of high-yield planting method of glutinous rice |
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