CN1739588A - Chinese medicine prepn for treating cardiac vascular diseases and its prepn - Google Patents
Chinese medicine prepn for treating cardiac vascular diseases and its prepn Download PDFInfo
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- CN1739588A CN1739588A CN 200510032114 CN200510032114A CN1739588A CN 1739588 A CN1739588 A CN 1739588A CN 200510032114 CN200510032114 CN 200510032114 CN 200510032114 A CN200510032114 A CN 200510032114A CN 1739588 A CN1739588 A CN 1739588A
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Abstract
The Chinese medicine preparation for treating cardiac vascular diseases is prepared with Chuanxiong rhizome and borneol as main material and may be prepared into quick acting micro pill, dispersant tablet or sublingual tablet. The preparation process includes separately crushing Chuanxiong rhizome and borneol into fine powder, reflux extraction of fine Chuanxiong rhizome powder with alcohol, decompression concentrating the extracted liquid, macroporous resin column adsorption, water washing, eluting with alcohol, decompression concentrating the eluted liquid, adding fine borneol powder, mixing homogeneously, adding proper amount of supplementary material, and further preparation into micro pill, dispersant tablet or sublingual tablet. The preparation has high medicinal effect.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, relate in particular to a kind of Chinese medicine preparation for the treatment of cardiovascular disease and preparation method thereof.
Background technology:
The existing dosage form of fast-acting heart disease curing has only drop pill by retrieval, has listed 18 in Chinese traditional patent formulation preparation promulgated by the ministries or commissions of the Central Government in.By patent retrieval, the Tianjin No.6 Chinese Medicines Factory is in 98 patents of having applied for the SUXIAO JIUXIN WAN manufacturing process, Zhang Qinglong has applied for the patent of a kind of fast-acting heart disease curing oral cavity disintegration tablet and preparation method thereof in calendar year 2001, University Of Tianjin has applied for the patent of fast-acting heart disease curing oral cavity disintegration tablet and preparation method, the relevant patent of no fast-acting heart disease curing micropill or dispersible tablet or Sublingual tablet in 2004.
Micropill in the Chinese medicine preparation or dispersible tablet or Sublingual tablet, change dosage form or technology and manage as new drug research according to the relevant laws and regulations of China's drug control as a kind of pharmaceutical dosage form.Micropill has at the gastrointestinal tract distribution area big, the bioavailability height, and zest is little, because particle diameter is little, is subjected to digestive tract to carry the food rhythm and pace of moving things to influence little (close as pylorus etc.), good fluidity, size evenly is easy to handle (as coating, divided dose); Dispersible tablet has good dispersing state, and disintegration time is short, and the medicine stripping is rapid, absorbs soon, and the bioavailability height, can be swallowed, chew to contain and suck or with taking after the aqueous dispersion taking convenience; Advantages such as Sublingual tablet can prevent that the different pH value of gastrointestinal tract to the influence of medicine and the digestive enzyme destruction to medicine, also can avoid the liver first-pass effect of medicine, and is rapid-action.
Existing SUXIAO JIUXIN WAN technology features is to get Rhizoma Chuanxiong in the prescription, extract with alcohol heating reflux, the extracting solution decompression recycling ethanol adds hydrochloric acid and regulates pH value, use chloroform extraction, chloroform layer adds hydrochloric acid, leaves standstill, and separates, water layer is regulated pH with ammonia, the reuse chloroform extraction, the reclaim under reduced pressure chloroform, solution concentration gets Rhizoma Chuanxiong extract; With the Polyethylene Glycol heating and melting, add Rhizoma Chuanxiong extract and Borneolum Syntheticum immediately, stir, splash in the liquid paraffin, promptly.
Existing SUXIAO JIUXIN WAN needs special equipment, cost height, complicated process of preparation etc.
Summary of the invention:
The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of cardiovascular disease and preparation method thereof, overcome the above-mentioned drawback of prior art, improved the quality of product, satisfied the needs of medical treatment better.
The objective of the invention is to be achieved through the following technical solutions.
A kind of Chinese medicine preparation for the treatment of cardiovascular disease, it is that main constituent is fast-acting heart disease curing micropill or the dispersible tablet or the Sublingual tablet of Rhizoma Chuanxiong, Borneolum Syntheticum.
Its preparation method is:
(1) medicine constituent and percentage by weight thereof are as follows:
Rhizoma Chuanxiong 65.3-88.4%, Borneolum Syntheticum 11.6-34.7%;
Medicine constituent optimum weight percentage ratio is:
Rhizoma Chuanxiong 76.9%, Borneolum Syntheticum 23.1%;
(2) get Rhizoma Chuanxiong, the Borneolum Syntheticum pulverize separately becomes fine powder, and is standby;
(3) get (2) gained Rhizoma Chuanxiong fine powder, use alcohol reflux 2-3 time, merge extractive liquid,, concentrating under reduced pressure, the macroporous adsorptive resins of flowing through again washes with water earlier, and reuse 20-50% ethanol carries out eluting, collects eluent, and concentrating under reduced pressure gets Rhizoma Chuanxiong extract, and is standby;
(4) get (3) gained Rhizoma Chuanxiong extract, add (2) gained Borneolum Syntheticum fine powder, mixing, it is standby to get hybrid medicine;
(5) get (4) gained hybrid medicine, add suitable adjuvant, mixing is made micropill or dispersible tablet or Sublingual tablet;
The preparation method of its micropill: get (4) gained hybrid medicine, add an amount of adjuvant, mix homogeneously is granulated, and coating or coating are not made the micropill of diameter less than 2.5mm, promptly get the fast-acting heart disease curing micropill;
The micropill adjuvant is following one or more combinations or other suitable adjuvant, uses with by arbitrary proportion: ethyl cellulose (EC), the polypropylene polysiloxanes, the wax class, Polyethylene Glycol (PEG), stearic acid, Lac, acrylic resin, polyvinyl alcohol, polyvinylpyrrolidone (PVP), methylcellulose, hydroxypropyl cellulose, cellulose propionate, the acrylic resin aqueous dispersion, the pseudo-latex of ethyl cellulose, cellulose acetate-phthalate (CAP) latex, polyphenyl dioctyl phthalate vinyl acetate (PVAP) aqueous dispersion, propylene glycol, glycerol, triacetin, acetyl list monoglyceride, phthalic acid ester, polyoxyethylene sorbitan monoleate, sodium lauryl sulphate, lactose, fructose, sucrose;
The preparation method of its dispersible tablet: get the hybrid medicine of (4) gained, add an amount of adjuvant, mix homogeneously, granulation, dry, granulate, tabletting promptly gets the fast-acting heart disease curing dispersible tablet;
Adjuvant is that one or more mixture or other suitable adjuvant used with by arbitrary proportion in the following material: low-substituted hydroxypropyl cellulose, dimension splash form sediment 5000, polyvinylpolypyrrolidone 1NF-10, Polyethylene Glycol, polyvidon class, methylcellulose, ethyl cellulose, hydroxypropyl emthylcellulose, cellulose acetate-phthalate, hydroxypropyl methylcellulose phthalate, hydroxymethyl ethyl cellulose, microcrystalline Cellulose, citric acid, cholic acid, fumaric acid, succinic acid, tartaric acid, colloidality silicon dioxide, magnesium stearate, Pulvis Talci;
The preparation method of its Sublingual tablet: get the hybrid medicine of (4) gained, add an amount of adjuvant, mix homogeneously, drying is pressed into Sublingual tablet;
Adjuvant is that one or more mixture or other suitable adjuvants used with by arbitrary proportion in the following material: carboxymethyl starch sodium, xylitol, sorbitol, lactose, sucrose, silicon dioxide, micropowder silica gel, tween 80, polyvinylpyrrolidone, mannitol, magnesium stearate.
Specific embodiments:
The present invention further specifies in conjunction with specific embodiments, can be for reference, but do not limit the scope of the invention:
A kind of Chinese medicine preparation for the treatment of cardiovascular disease, it is that main constituent is fast-acting heart disease curing micropill or the dispersible tablet or the Sublingual tablet of Rhizoma Chuanxiong, Borneolum Syntheticum.
A kind of Chinese medicine preparation for the treatment of cardiovascular disease of the present invention has promoting flow of QI and blood, stasis-dispelling and pain-killing, coronary blood flow increasing, allevating angina pectoris.Be mainly used in qi stagnation and blood stasis type coronary heart disease, angina pectoris.
Of the present inventionly a kind ofly treat the Chinese medicine preparation fast-acting heart disease curing micropill of cardiovascular disease or the preparation method of dispersible tablet or Sublingual tablet is:
(1) medicine constituent and weight consumption thereof are as follows:
Rhizoma Chuanxiong 100g, Borneolum Syntheticum 30g;
(2) get Rhizoma Chuanxiong, the Borneolum Syntheticum pulverize separately becomes fine powder, and is standby;
(3) get (2) gained Rhizoma Chuanxiong fine powder, use alcohol reflux 2 times, merge extractive liquid,, concentrating under reduced pressure, the macroporous adsorptive resins of flowing through again washes with water earlier, and reuse 30% ethanol carries out eluting, collects eluent, and concentrating under reduced pressure gets Rhizoma Chuanxiong extract, and is standby;
(4) get (3) gained Rhizoma Chuanxiong extract, add (2) gained Borneolum Syntheticum fine powder, mixing, it is standby to get hybrid medicine;
(5) a kind of Chinese medicine preparation fast-acting heart disease curing micropill for the treatment of cardiovascular disease, its preparation method is to get (4) gained hybrid medicine, with 30g dextrin mix homogeneously, 5%PVP alcohol liquid is binding agent, at first prepare 60 purpose granules and make parent nucleus, be binding agent with 5%PVP alcohol liquid again, add the mixed powder amplification and make 40 purpose micropills, promptly.
(6) a kind of Chinese medicine preparation fast-acting heart disease curing dispersible tablet for the treatment of cardiovascular disease, its preparation method is to get (4) gained hybrid medicine, adds cross-linking polyethylene pyrrolidone 30g, low-substituted hydroxypropyl cellulose 20g, microcrystalline Cellulose 100g, mix homogeneously, the secondary that sieves, the micropowder silica gel of adding 0.5%, mix homogeneously, cross 80 mesh sieve secondaries, tabletting promptly gets dispersible tablet.
(7) a kind of Chinese medicine preparation fast-acting heart disease curing Sublingual tablet for the treatment of cardiovascular disease, its preparation method is a fine drug powder of getting (4) gained, adds lactose 1.5g, sucrose 5g, carboxymethyl starch sodium 1g, magnesium stearate 0.2g, abundant mixing sieves, granulation, granulate, is pressed into Sublingual tablet.
Advantage of the present invention is:
Preparation technology is simple, takes, easy to carry, and constant product quality is conducive to improve drug effect.
Claims (3)
1, a kind of Chinese medicine preparation for the treatment of cardiovascular disease is characterized in that it is that main constituent is fast-acting heart disease curing micropill or the dispersible tablet or the Sublingual tablet of Rhizoma Chuanxiong, Borneolum Syntheticum.
2, a kind of preparation method for the treatment of the Chinese medicine preparation of cardiovascular disease, it is the preparation method of fast-acting heart disease curing micropill or dispersible tablet or Sublingual tablet, it is characterized in that:
(1) medicine constituent and percentage by weight thereof are as follows:
Rhizoma Chuanxiong 65.3-88.4%, Borneolum Syntheticum 11.6-34.7%;
(2) get Rhizoma Chuanxiong, the Borneolum Syntheticum pulverize separately becomes fine powder, and is standby;
(3) get (2) gained Rhizoma Chuanxiong fine powder, use alcohol reflux 2-3 time, merge extractive liquid,, concentrating under reduced pressure, the macroporous adsorptive resins of flowing through again washes with water earlier, and reuse 20-50% ethanol carries out eluting, collects eluent, and concentrating under reduced pressure gets Rhizoma Chuanxiong extract, and is standby;
(4) get (3) gained Rhizoma Chuanxiong extract, add (2) gained Borneolum Syntheticum fine powder, mixing, it is standby to get hybrid medicine;
(5) get (4) gained hybrid medicine, add suitable adjuvant, mixing is made micropill or dispersible tablet or Sublingual tablet;
The preparation method of its micropill: get (4) gained hybrid medicine, add an amount of adjuvant, mix homogeneously is granulated, and coating or coating are not made the micropill of diameter less than 2.5mm, promptly get the fast-acting heart disease curing micropill;
Micropill or pellet capsule adjuvant are following one or more combinations or other suitable adjuvant, use with by arbitrary proportion: ethyl cellulose (EC), the polypropylene polysiloxanes, the wax class, Polyethylene Glycol (PEG), stearic acid, Lac, acrylic resin, polyvinyl alcohol, polyvinylpyrrolidone (PVP), methylcellulose, hydroxypropyl cellulose, cellulose propionate, the acrylic resin aqueous dispersion, the pseudo-latex of ethyl cellulose, cellulose acetate-phthalate (CAP) latex, polyphenyl dioctyl phthalate vinyl acetate (PVAP) aqueous dispersion, propylene glycol, glycerol, triacetin, acetyl list monoglyceride, phthalic acid ester, polyoxyethylene sorbitan monoleate, sodium lauryl sulphate, lactose, fructose, sucrose;
The preparation method of its dispersible tablet: get the hybrid medicine of (4) gained, add an amount of adjuvant, mix homogeneously, granulation, dry, granulate, tabletting promptly gets the fast-acting heart disease curing dispersible tablet;
Adjuvant is that one or more mixture or other suitable adjuvant used with by arbitrary proportion in the following material: low-substituted hydroxypropyl cellulose, dimension splash form sediment 5000, polyvinylpolypyrrolidone 1NF-10, Polyethylene Glycol, polyvidon class, methylcellulose, ethyl cellulose, hydroxypropyl emthylcellulose, cellulose acetate-phthalate, hydroxypropyl methylcellulose phthalate, hydroxymethyl ethyl cellulose, microcrystalline Cellulose, citric acid, cholic acid, fumaric acid, succinic acid, tartaric acid, colloidality silicon dioxide, magnesium stearate, Pulvis Talci;
The preparation method of its Sublingual tablet: get the hybrid medicine of (4) gained, add an amount of adjuvant, mix homogeneously, drying is pressed into Sublingual tablet;
Adjuvant is that one or more mixture or other suitable adjuvants used with by arbitrary proportion in the following material: carboxymethyl starch sodium, xylitol, sorbitol, lactose, sucrose, silicon dioxide, micropowder silica gel, tween 80, polyvinylpyrrolidone, mannitol, magnesium stearate.
3, a kind of preparation method for the treatment of the Chinese medicine preparation of cardiovascular disease according to claim 2 is characterized in that the optimum weight percentage ratio of its main constituent is:
Rhizoma Chuanxiong 76.9%, Borneolum Syntheticum 23.1%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510032114 CN1739588A (en) | 2005-09-06 | 2005-09-06 | Chinese medicine prepn for treating cardiac vascular diseases and its prepn |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510032114 CN1739588A (en) | 2005-09-06 | 2005-09-06 | Chinese medicine prepn for treating cardiac vascular diseases and its prepn |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018040989A1 (en) * | 2016-08-29 | 2018-03-08 | 烟台益诺依生物医药科技有限公司 | Sublingual pharmaceutical composition of edaravone and (+)-2-borneol |
| CN109602710A (en) * | 2019-01-20 | 2019-04-12 | 怀化梅片科技有限公司 | A kind of borneol ball (piece) and preparation method thereof |
-
2005
- 2005-09-06 CN CN 200510032114 patent/CN1739588A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018040989A1 (en) * | 2016-08-29 | 2018-03-08 | 烟台益诺依生物医药科技有限公司 | Sublingual pharmaceutical composition of edaravone and (+)-2-borneol |
| AU2017317950B2 (en) * | 2016-08-29 | 2019-09-19 | Neurodawn Pharmaceutical Co., Ltd. | Sublingual pharmaceutical composition of edaravone and (+)-2-borneol |
| RU2720204C1 (en) * | 2016-08-29 | 2020-04-27 | Яньтай Енэфарма Ко., Лтд. | Sublingual pharmaceutical composition of edaravone and (+)-2-borneol |
| US11135199B2 (en) | 2016-08-29 | 2021-10-05 | Neurodawn Pharmaceutical Co., Ltd. | Sublingual pharmaceutical compositions of edaravone and (+)-2-borneol |
| CN109602710A (en) * | 2019-01-20 | 2019-04-12 | 怀化梅片科技有限公司 | A kind of borneol ball (piece) and preparation method thereof |
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