CN109602710A - A kind of borneol ball (piece) and preparation method thereof - Google Patents
A kind of borneol ball (piece) and preparation method thereof Download PDFInfo
- Publication number
- CN109602710A CN109602710A CN201910050837.XA CN201910050837A CN109602710A CN 109602710 A CN109602710 A CN 109602710A CN 201910050837 A CN201910050837 A CN 201910050837A CN 109602710 A CN109602710 A CN 109602710A
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- Prior art keywords
- borneol
- ball
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to pharmaceutical technology field and filed of daily-use chemical industry, and in particular to a kind of borneol ball (piece) and preparation method thereof.Existing borneol preparation is compound preparation, and borneol is graininess or flaky crystal, quantitatively divides agent to need accurate measuring device in medicine and daily chemicals field application, it has not been convenient to adjust and easily be scattered, volatilize and oxidation deterioration, direct use are restricted.The present invention proposes a kind of borneol ball (piece) and preparation method thereof for borneol directly blank inconvenient to use and folk prescription borneol preparation, the present invention.
Description
Technical field
The present invention relates to pharmaceutical technology field and filed of daily-use chemical industry, and in particular to a kind of borneol ball (piece) and its preparation side
Method.
Background technique
Borneol is a kind of cyclic monoterpenes class compound, molecular formula C10H18O.By its source difference, borneol can be divided into naturally
Borneol and borneolum syntheticum.Natural borneol is divided into d-Bomeol and L-Borneol because of the difference of optical activity.D-Bomeol is main certainly
The resin or Lauraceae of Dipterocarpaceae Dipterocarpus plant borneo camphor tree Dryobalanops aromatica Gaertner f. is planted
Fresh branch, the leaf of object camphor tree Cinnamomum Camphora (L.) Presl extracts processing and is made；L-Borneol is mainly from composite family
The fresh leaf of plant Blumea balsamifera Blumea Balsamifera (L.) DC. extracts processing and is made.Because of the difference of raw material and technique,
Often contain a certain proportion of camphor in natural borneol.Borneolum syntheticum is L-Borneol and d-Bomeol is racemic modification, and is contained
Epimer isoborneol.D-Bomeol, L-Borneol and borneolum syntheticum, the effect of all having inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain, receive
It is loaded into " Chinese Pharmacopoeia ".
Borneol has a wide range of applications in medicine and filed of daily-use chemical industry.As fragrance, borneol fragrance is refrigerant sharp, " this
Grass warp is dredged " meaning " hat that its perfume is hundred medicines " is the head perfume overcome others by displaying one's strength in blending." collected statements on the herbal foundation " records " gas of fragrance
All evilnesses can be warded off." Compendium of Material Medica then describes that " its gas first enters lung, passes in heart spleen, and can walk can dissipate, and makes poison gas surname dissipate in outer, then
Blood acne hair living, channels and collaterals item reach." as medicine, borneol acrid flavour, fragrance is walked to alter, priming uplink, former by the composition of prescription of monarch
Then, past borneol is seldom used as monarch drug in a prescription or folk prescription mainly as medicine compatible use is made.It is continuous with modern scientific research
It carries out, the promotion drug that borneol has promotes drug absorption, promotion transdermal through blood-brain barrier, increase blood-brain barrier permeability
It absorbs, drug is promoted to penetrate cornea, promote drug to penetrate schneiderian membrance, improve the speed that drug via intranasal application is absorbed into brain, confrontation
Circulatory system ischemic and myocardial damage caused by damage, mitigation ischemic, Central nervous system bidirectional modulation and protection, both calmness
Secondary injury, improvement are damaged awakening ability, promote Deiter's cells division, anti-inflammatory, town after restoring consciouness again, the protection cerebral ischemia of calming the nerves
Bitterly, antibacterial and antiviral, antifertility can make late pregnancy miscarry, and promote wound healing, increase granulation tissue structure and epidermis
Cytothesis is repaired skin accessory organ and is constantly revealed with stronger Wound Healing etc..Dismemberment study discovery, warp
Only storax and borneol play a crucial role in 15 taste medicine of allusion quotation prescription Suhexian Wan, simplify prescription dosage changing form Subing drop pills are made and both protected
Former side has been held for treating the curative effect of coronary heart diseases and angina pectoris and chest distress, and has been had the function of quick-acting.Borneol is in side in recent years
It plays a major role in agent and is increasingly taken seriously, the new drug for more simplifying prescription is developed, but is compound preparation, is not yet occurred
The single preparations of ephedrine of borneol.However borneol is graininess or flaky crystal, quantitatively agent is divided to need in medicine and daily chemicals field application
Accurate measuring device, it has not been convenient to adjust, and easily be scattered, volatilize and oxidation deterioration, direct use is restricted.
Summary of the invention
Goal of the invention: for borneol, directly blank inconvenient to use and folk prescription borneol preparation, the present invention propose a kind of dragon
Brain ball (piece) and preparation method thereof.
The purpose of the present invention is what is be achieved by the following technical programs:
(1) partial size is made in 2mm powder below or particle in borneol (d-Bomeol, L-Borneol or borneolum syntheticum)；
(2) appropriate stearic acid or magnesium stearate is added in borneol powder or particle, be uniformly mixed；
(3) by uniformly mixed powder or particle, spherical, the class ball being pressed by required dosage tablet press machine or other equipment
The borneol ball (piece) of sheet or sheet, special-shaped sheet.
The beneficial effects of the present invention are:
(1) borneol is quantitatively suppressed pelletization (piece) in advance by the present invention, and dosage is accurate, is adjusted easy；
(2) borneol is pressed into complete spherical, near-spherical or sheet, Special-shaped sheet by the broken little crystallization of particle, sheet by the present invention
Shape ball (ball) is not scattered and reduces volatilization, facilitates preservation and use；
(3) The present invention reduces the area that borneol is contacted with air, help to delay borneol oxidation deterioration, improve the matter of borneol
Measure stability；
(4) present invention except play borneol unique effects in addition to, borneol antibacterial, in terms of effect it is similar to camphor,
And camphor can be contained in raw material, also it can be changed into camphor by borneol is oxidable, therefore borneol ball can also play the effect of camphor ball, increase
The application range of borneol.
Specific embodiment:
Combined with specific embodiments below, the present invention will be further described.
Embodiment 1
Borneol (borneolum syntheticum) 150g is taken, 2mm or less particle is ground into, 10g magnesium stearate is added, is uniformly mixed, using tabletting
Machine installs the circular die tabletting of diameter 8mm, and every slice weight 0.16g obtains the every round borneol for being equivalent to borneolum syntheticum 0.15g
Piece, wherein borneol content about 55%.
Embodiment 2
Natural borneol (d-Bomeol) crystalline powder 500g is taken, 10g stearic acid, talcum powder 40g is added, is uniformly mixed, is used
Tablet press machine installs the oval punch die tabletting of 12mm specification, and every slice weight 0.55g obtains every and is equivalent to the ellipse of natural borneol 0.5g
Round borneol piece, wherein d-Bomeol content about 87%.
Embodiment 3
Graininess L-Borneol (L-Borneol) 600g is taken, with 8 mesh sieves, stearic acid 30g is added, is uniformly mixed, using using pressure
Piece machine installs the circular die tabletting of 15mm specification, and every slice weight 0.63g obtains the every spherical borneol for being equivalent to L-Borneol 0.6g
Ball, wherein L-Borneol content about 81%.
Embodiment 4
It is derived from the fresh branches and leaves of lauraceae plant camphor tree and extracts natural borneol crude product (wherein the d-Bomeol content 60%, camphor being processed into
Content 38%) 900g, with 8 mesh sieves, addition stearic acid 50g is uniformly mixed, using the circle of tablet press machine installation 18mm specification
Punch die tabletting, every slice weight 0.95g obtain spherical borneol ball, wherein d-Bomeol content about 56%.
Claims (4)
1. a kind of borneol ball (piece), which is characterized in that the borneol ball (piece) is made of 30%~99.5% borneol.
2. borneol ball (piece) as described in claim 1, which is characterized in that component borneol is d-Bomeol, L-Borneol, isoborneol
Thrin or three's any combination；Because of borneol source difference, camphor may be contained.
3. a kind of preparation method of borneol ball (piece), it is characterised in that borneol is made powder or particle, then by tablet press machine or
Other equipment suppress glomeration, class ball sheet, sheet or special-shaped Formulation.
4. a kind of preparation method of borneol ball (piece) as claimed in claim 3, which is characterized in that for the ease of tabletting, before tabletting
The acceptable excipient of appropriate tablet can be added, including but not limited to stearic acid or magnesium stearate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910050837.XA CN109602710A (en) | 2019-01-20 | 2019-01-20 | A kind of borneol ball (piece) and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910050837.XA CN109602710A (en) | 2019-01-20 | 2019-01-20 | A kind of borneol ball (piece) and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109602710A true CN109602710A (en) | 2019-04-12 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910050837.XA Pending CN109602710A (en) | 2019-01-20 | 2019-01-20 | A kind of borneol ball (piece) and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN109602710A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111631570A (en) * | 2020-06-08 | 2020-09-08 | 储和英 | Borneol particle filler for pillow and processing method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1739588A (en) * | 2005-09-06 | 2006-03-01 | 王衡新 | Chinese medicine prepn for treating cardiac vascular diseases and its prepn |
| CN102727590A (en) * | 2012-07-09 | 2012-10-17 | 武汉药谷科技开发有限公司 | Chinese herbal preparation for treating oral ulcer |
| US20180344684A1 (en) * | 2017-06-06 | 2018-12-06 | NC3 Systems | Cannabis-based therapeutic product for treatment of sleep disorders |
-
2019
- 2019-01-20 CN CN201910050837.XA patent/CN109602710A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1739588A (en) * | 2005-09-06 | 2006-03-01 | 王衡新 | Chinese medicine prepn for treating cardiac vascular diseases and its prepn |
| CN102727590A (en) * | 2012-07-09 | 2012-10-17 | 武汉药谷科技开发有限公司 | Chinese herbal preparation for treating oral ulcer |
| US20180344684A1 (en) * | 2017-06-06 | 2018-12-06 | NC3 Systems | Cannabis-based therapeutic product for treatment of sleep disorders |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111631570A (en) * | 2020-06-08 | 2020-09-08 | 储和英 | Borneol particle filler for pillow and processing method thereof |
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| PB01 | Publication | ||
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Application publication date: 20190412 |