CN102600324B - Externally used traditional Chinese medicine for treating rheumatoid arthritis - Google Patents
Externally used traditional Chinese medicine for treating rheumatoid arthritis Download PDFInfo
- Publication number
- CN102600324B CN102600324B CN2012100655358A CN201210065535A CN102600324B CN 102600324 B CN102600324 B CN 102600324B CN 2012100655358 A CN2012100655358 A CN 2012100655358A CN 201210065535 A CN201210065535 A CN 201210065535A CN 102600324 B CN102600324 B CN 102600324B
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- mineral water
- rhizoma
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides an externally used traditional Chinese medicine for treating rheumatoid arthritis, which is prepared by a main drug and mineral water. The main drug consists of bulk drugs including, by weight, from 3 to 5 parts of thunder god vine, from 0.5 to 1.5 parts of goldthread, from 1 to 3 parts of frankincense, from 3 to 5 parts of semen strychni, from 1 to 2 parts of hagworm, from 1 to 3 parts of myrrh, from 1.5 to 2.5 parts of hindu datura flowers, from 2 to 4 parts of monkshood, from 0.3 to 0.7 part of cantharides, from 1 to 2 parts of nidus vespae, from 2 to 7 parts of radix aconiti agrestis, from 0.1 to 0.2 part of musk, from 3 to 5 parts of rhizoma arisaematis, from 0.5 to 1.5 parts of centipede, from 0.1 to 0.2 part of bezoar, from 1 to 3 parts of rhizoma typhonii, from 1 to 3 parts of clove and from 0.5 to 1.5 parts of scorpio. The utilization quantity of the mineral water is 150-250 parts by volume, and when the unit of the weight of the main drug is gram, the unit of the volume of the mineral water is millimeter correspondingly. The externally used traditional Chinese medicine for treating rheumatoid arthritis has the advantages of safety, effectiveness, speediness, easiness in operation and high economical efficiency.
Description
Technical field
The present invention relates to a kind of external Chinese medicine, specifically refer to a kind of external Chinese medicine for the treatment of rheumatic arthritis.
Background technology
Rheumatic arthritis (RA) is a kind of chronic systemic autoimmune disease based on arthropathy.The clinical polyarthritis that mainly shows as symmetry, the joint is the most normal gets involved with hands, wrist, foot etc., in early days based on red, swollen, hot, bitterly and the dyskinesia, to late period visible ankylosis and deformity.The primary disease sickness rate is higher, abroad is generally about 1%, and China is 0.1%-0.3%, and morbidity is many with person between twenty and fifty, and 80% patient's age of onset is about 20-45 year.According to statistics, the primary disease disability rate is up to 60～70%, 10% patient disability in the several years wherein, serious harm numerous people healthy.
According to the clinical manifestation of primary disease, belong to Chinese medicine " arthromyodynia " category, especially similar to diseases such as " rheumatism involving the bone ", " severe and migratory arthralgia ", " arthroncus of knee ", " insensitive impediment ".Its cause of disease is the intrusion of exopathogen such as wind, cold, temperature, heat, and endogenous cause of ill is sought with plain bromhidrosis blood and defended deficiency, caused by liver and kidney deficiency is relevant.Main pathogenesis is pathogen numbness resistance meridians, and QI-blood circulation is unsmooth, and disease can cause the turbid blood stasis numbness resistance of nitrogen for a long time, and the QI and blood Liver and kidney is impaired, shows as the card of simulataneous insufficiency and excessive.
Doctor trained in Western medicine mainly adopts anti-inflammatory agent, antirheumatic and hormone antiinflammatory and immunosuppressant class Drug therapy at present, and its curative effect is all dissatisfied.(1) NSAID (non-steroidal anti-inflammatory drug).Having antiinflammatory, analgesia, effect such as analgesic, can alleviate the symptom of rheumatic arthritis, is one of clinical commonly used drug.This medicine can only play the anti-inflammatory analgetic effect, can not reduce or alleviate articular cartilage and osteoarticular destructive pathological changes, and more unable to get up suppresses the effect of course of disease progress, and life-time service can cause serious gastrointestinal tract toxic and side effects.(2) acting on the rheumatism medicine slowly mainly contains: anti-disease agent, golden preparation, penicillamine, press down the nitrogen sulfapyridine; Immunosuppressant: first ammonia butterfly Kazakhstan, cyclophosphamide, azathioprine, ciclosporin, Lay fluorine rice top grade, have the immunoreation of inhibition effect, can change the course of disease of rheumatic arthritis, but can not cure primary disease, and certain toxicity is arranged, can cause the patient to occur than serious adverse effects.(3) glucocorticoid, have powerful antiinflammatory action and certain immunosuppressive action, can improve patient's symptom, however the serious adverse reaction of glucocorticoid, limited its effect in the rheumatic arthritis treatment greatly, clinical commonly used drug has prednisone and De Baosong etc.
With external application of Chinese medicine method treatment rheumatic arthritis, it is the Perfected process that China traditional Chinese medical science educational circles pursues all the time.The wealth doctor opens to chinese tradition classical Chinese medicine theory in Chinese People's Armed Police Force---on the basis of interior disease external therapy further investigation and clinical practice, by to the scientific analysis of the cause of disease, pathogenesis, pharmacology, arthritis biological nature and animal model experiment with understand in depth, grasped the external application therapy of using Chinese medicine preparation, the treatment mechanism of radical cure rheumatic arthritis chases after air slaking stasis of blood cream thereby successfully developed Sichuan Cordyceps.This therapy need not performed the operation, and does not need oral various Chinese and western medicine to suppress the medicine of rheumatic arthritis, is a kind of safe, effective, quick, easy to operate new therapy of economy again.
Summary of the invention
Be difficult to the drawback that solves and can not effect a radical cure for overcoming existing treatment rheumatic arthritis medicine, the inventor has utilized the original bio-pharmacology characteristic of Chinese crude drug, scientifically succeeds in developing a kind of external Chinese medicine.
Technical scheme provided by the present invention is:
A kind of external Chinese medicine (Sichuan Cordyceps chases after air slaking stasis of blood cream) for the treatment of rheumatic arthritis, it is prepared from by principal agent and mineral water, and described principal agent is made up of following raw medicaments in portion by weight:
Described mineral water consumption is the 150-250 parts by volume, and when the unit of weight of principal agent was selected gram, the volume unit of mineral water was with regard to the corresponding selection milliliter.
Described principal agent preferably is made up of following raw medicaments in portion by weight:
Described mineral water preferable amount is 200 parts by volume, and when the unit of weight of principal agent was selected gram, the volume unit of mineral water was with regard to the corresponding selection milliliter.
The natural mineral water of southern foot, the Yuquanshan Mountain, the preferred Beijing of described mineral water special product.
Described Radix Tripterygii Wilfordii is the stem of removing crust and the root of Celastraceae plant Radix Tripterygii Wilfordii.Prescription another name: Thunder God with; Originate in ground such as Zhejiang, Anhui, Jiangxi, Hunan, Guangdong, Guangxi, Fujian, Taiwan, Yunnan.Excavate autumn, removes clean double-layer fur, dries, and gives birth to and use; Contain multiple alkaloid such as wilfordine, wilfordine, diterpenoid-lactone, triptonide and dulcitol etc.Nature and flavor: bitter, hot, cold.Very toxic; Function cures mainly: dispel the wind detoxifcation, parasite killing.The external treating rheumatic arthritis, skin is itched, and kills maggot, wriggler, water-snail eradication, malicious Mus.
Described Flos Daturae is the flower of plant of Solanaceae Flos Daturae.Prescription another name: Man Luohua, Flos Daturae flower, Chiba Flos Daturae flower, upright datura flower; Meridian distribution of property and flavor: acrid in the mouth, warm in nature; Poisonous.GUIXIN, lung, Liver Channel.Effect cures mainly: antiasthmatic-antitussive, and narcotic analgesic, spasmolytic is only jerked.Be used for asthma and cough, coldness and pain in the epigastrium, rheumatic arthralgia, epilepsy, infantile convulsion, surgical anesthesia.
Described Agkistrodon halys (Agkistrodon halys) belongs to the Viperidae Agkistrodon halys and belongs to, and flies on another name God in charge of the Earth Serpentis, the grass; Head is slightly triangular in shape, the body tubbiness, and tail is short, and the full back of the body is crineous, and respectively there is the circular speckle of dark brown delegation on the side.Strong tolerance to cold is arranged.Inhabit Plain, hilly country, wilderness, limit, field and roadside more.Very high pharmaceutical value is arranged.Gui Jing: spleen, Liver Channel; Effect: dispel the wind collateral dredging, pain relieving, detoxifcation; Cure mainly: rheumatic arthralgia, leprosy, scrofula, furuncle, scabies, haemorrhoids, tumor; Gather and store: catch between spring and summer.Catch after cut open the belly and remove internal organs, coil into disc, oven dry.But also using fresh herb.
Described Nidus Vespae (Honey comb) comes from Shennong's Herbal.Another name honeybee intestinal, leather honeybee case, hundred are worn, honeybee is put down, Nidus Vespae, Radix Et Rhizoma Rhei beehive etc.; Latin plant animal mineral name: Polistes mandarinus Saussure; Be the long foot wasp of Vespidae insecticide yellow star or multiple nearly edge insecticide nest; General 10-12 gathered between the month, dried after adopting, and poured out dead honeybee, and attached decontamination is cut into bulk, gave birth to or fry, forge usefulness; Chemical analysis: Hornet nest contains and reveals room oil, Cera Flava, resin, various saccharides, vitamin and inorganic salt etc.
The present invention also provides described external preparation method of Chinese medicine, may further comprise the steps:
Radix Tripterygii Wilfordii, Semen Strychni, Flos Daturae, Nidus Vespae, Rhizoma Arisaematis, Rhizoma Typhonii, Rhizoma Coptidis, Agkistrodon halys, Radix Aconiti, Radix Aconiti Kusnezoffii, Scolopendra, Flos Caryophylli, Olibanum, Myrrha, Mylabris, Moschus, Calculus Bovis and Scorpio 18 flavor crude drug with described ratio; be ground into 200 order fine powders; the natural mineral water that adds described volume; boil through warm fire; when the formation water content reaches 20% paste; underground 2 chi depths are imbedded in the cooling of ceasing fire, the secluding air fermentation after 3 months namely.
Described pulverizing preferably uses rustless steel pulverizing machine to finish.
Describedly boil preferred use porcelain ware and finish as container.
In the described preparation method, the sweat that paste is imbedded underground secluding air can make that each crude drug fully merges in the principal agent, thereby content of effective is wherein got a promotion to greatest extent.Therefore this process can significantly improve the therapeutic effect of external Chinese medicine of the present invention.
Method treatment rheumatic arthritis with the external application of Chinese medicine, its great advantage do not need to be by operating on operation, do not need oral various Chinese and western medicine to suppress the medicine of rheumatic arthritis, the toxic and side effects of having avoided postoperative infection and oral medicine to produce only needs can to effect a radical cure rheumatism joint by the external application administration and treats scorching.This therapy is safe, effective, quick, easy to operate and economical, and it is painful that patient does not have treatment.
The method of using external treatment by Chinese herbs rheumatic arthritis of the present invention is as follows:
1. make a definite diagnosis rheumatic arthritis according to the modern medical diagnosis technology:
(1) joint performance: morning deadlock, pain, swelling, deformity, dysfunction.
(2) show outside the joint: rheumatoid nodules, rheumatoid vasculitis, the change of interstitial lung sexually transmitted disease (STD), pericarditis, gastrointestinal upset, kidney urine unusual, low hemoglobin small cell anemia, keratoconjunctivitis sicca and xerostomia.
(3) laboratory and other auxiliary examinations: the biopsy of routine blood test, erythrocyte sedimentation rate, c reactive protein, rheumatoid factor (RF), immune complex and complement, knuckle synovia, joint X ray examination and rheumatoid nodules.
(4) diagnostic criteria:
1), morning the continuous 1h (every day) at least that refuses to budge, at least 6 weeks of the course of disease;
2), the swollen joint more than 3 or 3, at least 6 weeks are arranged;
3), wrist, the palm refer to, closely articulations digitorum manus is swollen, at least 6 weeks;
4), the symmetry swollen joint, at least 6 weeks;
5), hands X line is taken the photograph sheet change (having the narrow of osteoporosis and joint space at least);
6), subcutaneous nodule is arranged;
7), rheumatoid factor be positive (titre＞1: 20).
2. drug treatment:
According to the direct external application administration in arthritis focus position of making a definite diagnosis.
The course for the treatment of: generally only need 1-2 external application administration a course for the treatment of.
Usage and dosage: every day, external application was administered once, and each external application administration accumulated dose 35 grams (paste) stayed medicine 24 hours.Should aim at lesions position dispenser (paste plaster external application---surgical membrane covers completely---immobilization with adhesive tape) during the Traditional Chinese Medicine for external application operation.
Clinical manifestation: 1, the 1-2 hour efficacy of a drug can all be infiltrated the focus joint after the drug of topical application; 2, stayed medicine through 24 hours, ooze out because of tissue fluids in a large number between visible focus joint exocuticle and corium, can heave 1 blister with medicated bag equivalent size, its sick cell tissue fluid is yellowish red color.Can adopt bamboo let and peg wood to puncture blister during clinical treatment, drain tissue fluid and get final product.3, the blister that drains tissue fluid can be voluntarily dry and hard through 7-10 days, form a scab and come off, can not form infection.
3. make a definite diagnosis the standard of healing:
Arthritic symptom disappears: the lab testing corresponding index recovers normal; Hands X line is taken the photograph the sheet no abnormality seen and is changed; Subcutaneous nodule disappears.
External Chinese medicine of the present invention can be with reference to the pharmacodynamics test of following animal model to the therapeutic effect of rheumatic arthritis:
1. experiment material
Tried thing: the Chinese medicine lotion for external use agent of the embodiment of the invention 1 is used for skin and smears administration.
Negative control product: excipient.Compound method: starch and distilled water are mixed with paste by mass ratio at 3: 2, put 4 ℃ of refrigerators and preserve.
Positive reference substance: diclofenac diethylammonium emulsion agent (diclofenac), Novartis Pharma AG's product.Specification: 20 grams: 0.2 gram (in diclofenac sodium), sealing is preserved below 30 ℃.Face the time spent and directly extrude a small amount of coating skin surface.
2. experiment content:
[rat assist agent arthritis experiment]
Principle: immunological adjuvant is in immunologic process, can non-specific promotion antigen sensibilization process and the auxiliary material that improves immune effect.In the right back sufficient lift of rat behind the injection Freund's complete adjuvant, primary affection and secondary affection can appear.Primary affection is similar to general inflammatory edema, mainly shows as to cause scorching local inflammatory reaction (joint, toes redness), causes the 18-24 hour peaking in scorching back, continues to alleviate gradually after 5 days; Secondary affection causes by delayed hypersensitivity, after causing scorching 10d, and offside and forelimb foot pawl generation swelling, polyarthritis, struvite tuberosity and erythema also appear in ear, afterbody, and obviously descend with body weight.This kind secondary reactions be by Freund's complete adjuvant as antigen, bring out body and produce due to the autoimmune response.In 1 week behind the injection Freund's complete adjuvant, the scoring of injection side arthralgia namely significantly raises, and keeps more than 6 weeks, to basic recovery of 9 weeks.
Method: male Wistar rat, is divided into 3 groups by body weight, 12 every group at random by 36.Be respectively: (1) blank group (A), (2) positive controls (B), (3) are tried thing group (C).Each only organizes the right back toes intradermal injection of rat Freund's complete adjuvant 0.1mL/.After the preceding 1h of modeling and the modeling administration, tried thing group rat and smeared the external Chinese medicine of embodiment 1 respectively at right back whole toe position and back, the positive controls rat is smeared diclofenac, blank group rat is smeared excipient, each rat respectively at administration before 24h shave except back center position hair, shave gross area and be about 3.3cm.Successive administration five days, every day twice, each applying amount 0.5g/ only.18h before the modeling and after the modeling (be 1d, 2d, 3d, 5d measure respectively each rat toes volume (before the modeling at the right back ankle joint position of each rat with the standardized horizontal line of marking pen, each is note with this horizontal line when measuring the toes volume), calculate each rat foot claw swelling degree (mL) and respectively organize inhibitory rate of intumesce:
Toes volume before the scorching back of swelling degree (mL)=cause toes volume-cause is scorching
Suppression ratio %=(blank group swelling degree-administration group swelling degree)/blank group swelling degree * 100%
[carrageenin causes rat foot claw swelling experiment]
Principle: imitate proinflammatory agent during carrageenin belongs to, injection carrageenin in the rat paw can cause that local telangiectasis, vascular permeability increase, ooze out, edema etc. is a series of is similar to the acutely inflamed reaction of human body.Cause the scorching about 0.5h in back and begin swelling, 2.5-3.0h peaks, and disappears gradually behind the 8h.This model is reliable, diversity is little, the height repeatability is arranged.
Method: the Wistar rat, 36, male and female half and half are divided into 3 groups at random by body weight, and male and female are grouping separately, 12 every group.Be respectively: (1) blank group (A1), (2) positive controls (B1), (3) are tried thing group (C1).24h respectively organizes the rat back depilation before the administration, is tried thing group rat in the depilation back and injects the external Chinese medicine of sufficient partial smearing embodiment 1, and blank group rat is smeared excipient, the positive controls rat is smeared diclofenac, successive administration 3 days, every day 2 times, each applying amount 0.5g/ only.After the administration in the 3rd day behind the 1h, each Mus is irritated stomach feedwater 10mL, right back toes subcutaneous injection 1% carrageenin 0.1mL/ only causes inflammation, before the Yu Zhiyan and cause scorching back 0.5h, 1h, 2h, 4h, 6h measures the right back ankle girth of each Mus respectively, calculate and respectively organize sufficient pawl swelling degree (cm) and suppression ratio (%):
Ankle girth before the scorching back of swelling degree (cm)=cause ankle girth-cause is scorching
Suppression ratio %=(blank group swelling degree-administration group swelling degree)/blank group swelling degree * 100%.
[experiment of mice acetic acid twisting]
Principle: the chemical stimulation material of a constant volume and concentration is injected in the mouse peritoneal, stimulate visceral layer and parietal peritoneum, cause that the deep than the inflammatory pain of large tracts of land long period, causes mice behavior reactions such as abdominal part indent, trunk and hind leg extension, hips up to occur, be called writhing response.This is reflected at frequency of occurrences height in the 15min of injection back, thus with take place in the injection 15min turn round the body number of times or the writhing response time started is the pain quantitative target.
Method: 40 of male mouse of kunming are divided into 4 groups at random by body weight, 10 every group.Be respectively: (1) blank group (A2), (2) model control group (B2), (3) positive controls (C2), (4) are tried thing group (D2).24h respectively organizes the mouse web portion depilation before the administration, is tried thing group mouse web portion depilation position and smears embodiment 1 external-applied ointment, and blank group mice is smeared excipient, the positive controls mice is smeared diclofenac, successive administration three days, every day twice, each applying amount 0.2g/ only.After administration in the 3rd day, each mouse peritoneal is only injected 0.6% acetic acid 0.2mL/, blank group mouse peritoneal injecting normal saline 0.2mL/ only, the time started of each mouse writhing number of times and each mouse writhing in the record 15min (person that do not occur turning round the body, begin to turn round body time be designated as 15min).
[mice ear experiment]
Principle: dimethylbenzene be adjacent,, the mixture of three kinds of isomerss of para-position, its proinflammatory effect has strong again soon, coats behind the mouse ear expansion rapidly and soaks into, and the permeability of its blood capillary is increased, and the inflammatory reaction of Mus ear redness occurs.This model method is easy, instant effect, dosage are few, and is copied into the power height, is applicable to the conventional screening of antiinflammatory action.
Method: 30 of male mouse of kunming are divided into 3 groups at random by body weight, 10 every group.Be respectively: (1) blank group (A3), (2) positive controls (B3), (3) are tried thing group (C3).24h before the administration, each organizes the mouse web portion depilation, is tried the external-applied ointment that embodiment 1 is smeared at thing group mouse web portion depilation position, blank group mice is smeared excipient, and positive controls is smeared diclofenac, successive administration three days, every day twice, each applying amount 0.2g/ only.After administration in the 3rd day, only respectively be coated with dimethylbenzene 0.02mL/ with micro sample adding appliance two sides before and after each Mus auris dextra, behind the 2h, each Mus is put to death in the cervical vertebra dislocation, cuts ears along the auricle baseline, lays circular auricle at same position respectively with 9mm diameter card punch, weighs.Calculate each mice ear degree (mg) and respectively organize ear swelling suppression ratio (%):
Ear swelling degree (mg)=every Mus auris dextra sheet weight-left auricle weight is swelling degree (mg)
Inhibitory rate of intumesce (%)=(blank group swelling degree-administration group swelling degree)/blank group swelling degree * 100%.
3. experimental result
3.1 the effect (seeing Table 1) to rat assist agent arthritis
The external Chinese medicine of table 1. embodiment 1 to the influence of adjuvant arthritis rats toes swelling degree (mL) and inhibitory rate of intumesce (%) (X ± SD, n=12)
Annotate: compare with the blank group:
*P＜0.05,
*P＜0.01,
* *P＜0.001.
By table 1 as seen, cause scorching back the 1st day, the toes swelling degree of blank group rat has reached peak value, and the modeling success is described; Compare with the blank group, tried the thing group and caused the inhibitory action of property significantly (P＜0.05 or P＜0.001) that scorching back all showed adjuvant arthritis rats toes swelling degree on the the 1st, 2 day, after this descending naturally along with adjuvant arthritis rats model toes swelling degree, it is very not remarkable that the inhibitory action of medicine of the present invention seems gradually, shows that external Chinese medicine of the present invention is fairly obvious to the inflammation control of acute stage.Under the same experimental condition, the positive control drug diclofenac reveals inhibitory action (P＜0.05 or P＜0.001) strongly to the toes swelling kilsyth basalt of adjuvant arthritis rats.
The external Chinese medicine on Carrageenan of table 2. embodiment 1 cause scorching back rat foot claw swelling degree (mL) and suppression ratio (%) influence (X ± SD, n=12)
Annotate: compare with the blank group:
*P＜0.05,
*P＜0.01,
* *P＜0.001.
By table 2 result as seen, blank group rat has begun swelling in causing scorching back 0.5h foot pawl, along with further developing of inflammation, peaks in 2.0h-4.0h time period swelling, and swelling is after this disappeared gradually, and the modeling success is described.When causing inflammation back 1.0h, tried thing group rat foot claw swelling degree and significantly be lower than blank group (P＜0.05 or P＜0.001).Cause the scorching back 2.0h-4.0h stage, tried thing group rat foot claw swelling degree and blank group and reduction to a certain degree relatively occurred.When causing inflammation back 6.0h, tried thing group rat foot claw swelling degree and still be lower than the blank group.Positive controls rat foot claw swelling degree compares with the blank group respectively in each time point, significant difference (P＜0.05, or P＜0.01 or P＜0.001) all occurred.
3.3 the effect to the mice acetic acid twisting
The influence of the mouse writhing number of times that the external Chinese medicine Dichlorodiphenyl Acetate of table 3. embodiment 1 causes (X ± SD, n=10)
Annotate: compare with the blank group:
△ △ △P＜0.001; Compare with model control group: * * P＜0.01, * * * P＜0.001.
The result of the mouse writhing effect that table 3 causes for the external Chinese medicine Dichlorodiphenyl Acetate of the embodiment of the invention 1.The result shows, with model control group relatively, tried thing group mouse writhing number of times and significantly reduced (P＜0.01), show that it may have certain analgesic activity, and tried thing group mice begin turn round the body time and model control group is roughly suitable.Under the same experimental condition, positive control drug diclofenac and model control group are relatively turned round the body number of times and are significantly reduced (P＜0.01), turn round the body time started obviously to be later than model control group, show stronger analgesic activity.
3.4 the effect to mice ear
The influence of the mice ear degree that the external Chinese medicine xylol of table 4. embodiment 1 causes (X ± SD, n=10)
Annotate: compare with the blank group: * P＜0.05, * * P＜0.01, * * * P＜0.001.
The exercising result of the mice ear that table 4 causes for the external Chinese medicine xylol of the embodiment of the invention 1.The result shows, with the blank group relatively, tried thing group mice ear degree and significantly be lower than blank group (P＜0.05), demonstrate the acute inflammation that its xylol causes and have certain inhibitory action, suppression ratio is up to 44%.Under the same experimental condition, positive controls (diclofenac) mice ear degree all significantly is lower than blank group (P＜0.05), demonstrates the acute inflammation that its xylol causes and has certain inhibitory action, suppression ratio 42%.
In addition, the inventor has also carried out acute toxicity test and long term toxicity research to external Chinese medicine of the present invention.
The observable conclusion of acute toxicity test is that external Chinese medicine skin of the present invention sticks and continues medication that (administration was 2 times in 24 hours in 24 hours, to be sticked totally 24 hours persistent period), the administration local skin is caused damage (blue patch, eschar), but skin lesion spontaneous recovery in 2 weeks.
Long term toxicity research is observed and is found, the Wistar rat can make the weight of animals increasing degree, food-intake and food consumption rate obviously descend when the skin external application repeatedly gives the external Chinese medicine of embodiment 1, can seriously cause the damage of skin, cause administration place epiderm skin ulcer, epidermal hyperplasia, hyperkeratosis, companion's cell infiltration, granulation tissue hyperplasia, the skin corium proliferation of fibrous tissue, vasodilation hyperemia, pathologic lesions such as part myocyte's degeneration necrosis, thus irritability ground causes the change of part blood parameters in range of normal value.Each main organs is not seen the infringement of organic pathology, and drug withdrawal can progressively recover, and the influence that shows medicine is reversible, no cumulative action.
By above-mentioned every result of the test as can be known, external Chinese medicine of the present invention has anti-cell mediated hypersensitivity inflammatory effect, and anti-nonspecific inflammation effect, and may have certain analgesic activity, can significantly improve the clinical symptoms of rheumatic arthritis.External Chinese medicine of the present invention has lower toxicity simultaneously, can not produce obvious damage to body.
The specific embodiment
Embodiment 1.
A kind of external Chinese medicine (Sichuan Cordyceps chases after air slaking stasis of blood cream) for the treatment of rheumatic arthritis, it is prepared from by the principal agent of following weight and the natural mineral water of southern foot, the Yuquanshan Mountain, 200mL Beijing special product:
Described external Chinese medicinal preparation method is as follows:
Radix Tripterygii Wilfordii, Semen Strychni, Flos Daturae, Nidus Vespae, Rhizoma Arisaematis, Rhizoma Typhonii, Rhizoma Coptidis, Agkistrodon halys, Radix Aconiti, Radix Aconiti Kusnezoffii, Scolopendra, Flos Caryophylli, Olibanum, Myrrha, Mylabris, Moschus, Calculus Bovis and Scorpio 18 flavor crude drug with described weight; be ground into 200 order fine powders with rustless steel pulverizing machine; the natural mineral water that adds 200mL; in the porcelain ware, boil through warm fire; when the formation water content reaches 20% paste; underground 2 chi depths are imbedded in the cooling of ceasing fire, the secluding air fermentation after 3 months namely.
Embodiment 2.
A kind of external Chinese medicine (Sichuan Cordyceps chases after air slaking stasis of blood cream) for the treatment of rheumatic arthritis, it is prepared from by principal agent and the 250mL natural mineral water of following weight:
Described external Chinese medicinal preparation method is as follows:
Radix Tripterygii Wilfordii, Semen Strychni, Flos Daturae, Nidus Vespae, Rhizoma Arisaematis, Rhizoma Typhonii, Rhizoma Coptidis, Agkistrodon halys, Radix Aconiti, Radix Aconiti Kusnezoffii, Scolopendra, Flos Caryophylli, Olibanum, Myrrha, Mylabris, Moschus, Calculus Bovis and Scorpio 18 flavor crude drug with described weight; be ground into 200 order fine powders with rustless steel pulverizing machine; the natural mineral water that adds 250mL; in the porcelain ware, boil through warm fire; when the formation water content reaches 20% paste; underground 2 chi depths are imbedded in the cooling of ceasing fire, the secluding air fermentation after 3 months namely.
Embodiment 3.
A kind of external Chinese medicine (Sichuan Cordyceps chases after air slaking stasis of blood cream) for the treatment of rheumatic arthritis, it is prepared from by principal agent and the 150mL natural mineral water of following weight:
Described external Chinese medicinal preparation method is as follows:
Radix Tripterygii Wilfordii, Semen Strychni, Flos Daturae, Nidus Vespae, Rhizoma Arisaematis, Rhizoma Typhonii, Rhizoma Coptidis, Agkistrodon halys, Radix Aconiti, Radix Aconiti Kusnezoffii, Scolopendra, Flos Caryophylli, Olibanum, Myrrha, Mylabris, Moschus, Calculus Bovis and Scorpio 18 flavor crude drug with described weight; be ground into 200 order fine powders with rustless steel pulverizing machine; the natural mineral water that adds 150mL; in the porcelain ware, boil through warm fire; when the formation water content reaches 20% paste; underground 2 chi depths are imbedded in the cooling of ceasing fire, the secluding air fermentation after 3 months namely.
Claims (5)
1. external Chinese medicine for the treatment of rheumatic arthritis, it is prepared from by principal agent and mineral water, it is characterized in that, and described principal agent is made up of following raw medicaments in portion by weight:
Radix Tripterygii Wilfordii 3-5 Rhizoma Coptidis 0.5-1.5 Olibanum 1-3 Semen Strychni 3-5
Agkistrodon halys 1-2 Myrrha 1-3 Flos Daturae 1.5-2.5 Radix Aconiti 2-4
Mylabris 0.3-0.7 Nidus Vespae 1-2 Radix Aconiti Kusnezoffii 2-7 Moschus 0.1-0.2
Rhizoma Arisaematis 3-5 Scolopendra 0.5-1.5 Calculus Bovis 0.1-0.2 Rhizoma Typhonii 1-3
Flos Caryophylli 1-3 Scorpio 0.5-1.5;
Described mineral water consumption is the 150-250 parts by volume, and when the unit of weight of principal agent is selected gram, the volume unit corresponding selection milliliter of mineral water.
2. the described external Chinese medicine of claim 1 is characterized in that described principal agent is made up of following raw medicaments in portion by weight:
Radix Tripterygii Wilfordii 4 Rhizoma Coptidis 1 Olibanum 2 Semen Strychni 4
Agkistrodon halys 1.6 Myrrhas 2 Flos Daturaes 2 Radix Aconitis 3
Mylabris 0.5 Nidus Vespae 1.6 Radix Aconiti Kusnezoffii 3 Moschus 0.15
Rhizoma Arisaematis 4 Scolopendras 1 Calculus Bovis 0.15 Rhizoma Typhonii 2
Flos Caryophylli 2 Scorpios 1.
3. the described external Chinese medicine of claim 1, it is characterized in that: described mineral water consumption is 200 parts by volume, and when the unit of weight of principal agent is selected gram, the volume unit corresponding selection milliliter of mineral water.
4. the described external Chinese medicine of claim 1, it is characterized in that: described mineral water is the natural mineral water of southern foot, the Yuquanshan Mountain, Beijing special product.
5. the described external preparation method of Chinese medicine of claim 1, its step is as follows:
Radix Tripterygii Wilfordii, Semen Strychni, Flos Daturae, Nidus Vespae, Rhizoma Arisaematis, Rhizoma Typhonii, Rhizoma Coptidis, Agkistrodon halys, Radix Aconiti, Radix Aconiti Kusnezoffii, Scolopendra, Flos Caryophylli, Olibanum, Myrrha, Mylabris, Moschus, Calculus Bovis and Scorpio 18 flavor crude drug with described part by weight; be ground into 200 order fine powders; the natural mineral water that adds described volume; be boiled into water content when reaching 20% paste through warm fire; cease fire and cool off; imbed underground 2 chi depths, secluding air fermentation after 3 months namely.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100655358A CN102600324B (en) | 2012-01-13 | 2012-01-13 | Externally used traditional Chinese medicine for treating rheumatoid arthritis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100655358A CN102600324B (en) | 2012-01-13 | 2012-01-13 | Externally used traditional Chinese medicine for treating rheumatoid arthritis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102600324A CN102600324A (en) | 2012-07-25 |
| CN102600324B true CN102600324B (en) | 2013-08-14 |
Family
ID=46518343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100655358A Active CN102600324B (en) | 2012-01-13 | 2012-01-13 | Externally used traditional Chinese medicine for treating rheumatoid arthritis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102600324B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877428B (en) * | 2014-04-19 | 2016-06-08 | 高建华 | A kind of medicine treating osteoarthritis and preparation method |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100455280C (en) * | 2006-05-01 | 2009-01-28 | 杨树民 | An externally applied ointment |
-
2012
- 2012-01-13 CN CN2012100655358A patent/CN102600324B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN102600324A (en) | 2012-07-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103751663B (en) | A kind of Chinese medicine for external application treating anal eczema and preparation method thereof | |
| CN102380015B (en) | Medicinal composition for treating rheumatoid arthritis and preparation method and application thereof | |
| CN103405582B (en) | Traditional Chinese medicine composition for improving joint gall of rheumatoid arthritis | |
| CN104258278A (en) | Gushangling (for bone injury) spray | |
| CN101584810B (en) | Medicine composition for treating gastritis and peptic ulcer and preparation method thereof | |
| CN102631464B (en) | Chinese medicinal ointment for treating infantile hemangioma and preparation method thereof | |
| CN101991811B (en) | Traditional Chinese medicine composition for treating rheumatism arthralgia, cold headache, abdominal cavity pain and chilblain and preparation method thereof | |
| CN105497534A (en) | Protection product for preventing and treating electric employee electric burn and fire burn | |
| CN102600324B (en) | Externally used traditional Chinese medicine for treating rheumatoid arthritis | |
| CN103393999A (en) | Anti-inflammatory resolutive liquid medicine for promoting blood circulation to arrest pain | |
| CN102038778A (en) | Chinese medicinal composition with effects of relaxing meridians, activating collaterals, expelling wind and removing dampness and preparation method thereof | |
| CN101450117B (en) | Rheumatism treatment medicine composition, formulation and preparation method | |
| CN101912570B (en) | Medicinal composition for treating rheumatism and preparation method thereof | |
| CN101690746B (en) | Chinese herbal preparation for treating soft tissue injuries and fractures | |
| CN103705556B (en) | One treats tetanic Chinese medicine composition | |
| CN102526335B (en) | Externally applied traditional Chinese medicine for treating gout | |
| CN107929492A (en) | A kind of strong doctor's external preparation for treating abscess and preparation method thereof | |
| CN105497535A (en) | Preparation technology of preparation for treating electrical burn | |
| CN105233113A (en) | External use tincture medicine treating tinea corporis, tinea cruris and tinea manus and tinea pedis and preparation method thereof | |
| CN104474469A (en) | Method for preparing electric injury paste preparation | |
| CN103933278A (en) | Preparation method of Tibetan drug for treating gout disease | |
| CN103372170A (en) | External traditional Chinese medicine for treating pyretic arthralgia, and preparation method thereof | |
| CN114917309A (en) | Dai medicine composition for external use for treating gouty arthritis and application | |
| CN103070998B (en) | Externally-applied plaster for curing pain of rheumatic joints | |
| CN106266205A (en) | A kind of for promoting the middle-aged and elderly people Chinese medicine formula of diabetic foot rehabilitation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |