CN1733068A - Chinese medicinal preparation for promoting blood circulation, dissipating blood stasis, inducing reuscitation with aromatics and preparation process thereof - Google Patents
Chinese medicinal preparation for promoting blood circulation, dissipating blood stasis, inducing reuscitation with aromatics and preparation process thereof Download PDFInfo
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- CN1733068A CN1733068A CN 200510031934 CN200510031934A CN1733068A CN 1733068 A CN1733068 A CN 1733068A CN 200510031934 CN200510031934 CN 200510031934 CN 200510031934 A CN200510031934 A CN 200510031934A CN 1733068 A CN1733068 A CN 1733068A
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Abstract
The invention relates to a Chinese medicinal preparation for promoting blood circulation, dissipating blood stasis, inducing reuscitation with aromatics and preparation process, wherein the main constituents include Ligusticum wallichii, sophora bud, root of red rooted saliva, leeches, ilex pedunculosa, cow-bezoar, musk, ginseng saponin, boneol and secretio bufonis, and can be made into drop pills, microcapsules or soft capsules.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, relate in particular to Chinese medicine preparation of a kind of causing resuscitation with aromatic drugs promoting blood circulation to remove blood stasis and preparation method thereof.
Background technology:
Drop pill in the Chinese medicine preparation or micropill or pellet capsule or soft capsule, change dosage form and manage as new drug research according to the relevant laws and regulations of China's drug control as a kind of pharmaceutical dosage form.The existing dosage form of this product is a capsule, has listed the national drug ministry standard in.
The capsular technology features of Chinese medicine preparation XUESHUANXINMAINING of existing causing resuscitation with aromatic drugs promoting blood circulation to remove blood stasis is got Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Ilicis Pubescentis ethanol extraction, reclaims ethanol and is condensed into cream, drying and crushing; Hirudo is used alcohol reflux, is condensed into thick paste, is dried to powder; The Flos Sophorae Immaturus is dried to powder with the limewater extraction rutin, and Venenum Bufonis is pulverized and is impalpable powder, adds Moschus, Borneolum Syntheticum, Calculus Bovis fine powder, and mixing divides the capsule of packing into, promptly.
There are shortcomings such as easy moisture absorption, produce effects is slow, bioavailability is low in existing XUESHUANXINMAINING capsule.
Summary of the invention:
The purpose of this invention is to provide Chinese medicine preparation of a kind of causing resuscitation with aromatic drugs promoting blood circulation to remove blood stasis and preparation method thereof, overcome the drawback of prior art, improve the quality and the curative effect of product, satisfy the needs of medical treatment better.
The objective of the invention is to be achieved through the following technical solutions.
A kind of Chinese medicine preparation of causing resuscitation with aromatic drugs promoting blood circulation to remove blood stasis, it is XUESHUANXINMAINING drop pill or micropill or the pellet capsule or the soft capsule of main component Rhizoma Chuanxiong, the Flos Sophorae Immaturus, Radix Salviae Miltiorrhizae, Hirudo, Radix Ilicis Pubescentis, Calculus Bovis, Moschus, stem and leaf of Radix Ginseng saponin, Borneolum Syntheticum, Venenum Bufonis;
Its preparation method is:
(1) medicine constituent and percentage by weight consumption thereof are as follows:
Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae each 25～35%, the Flos Sophorae Immaturus, Radix Ilicis Pubescentis each 10～20%, Hirudo 5～10%, Calculus Bovis 0.5～1%, Moschus, Venenum Bufonis each 0.02～0.10%, stem and leaf of Radix Ginseng saponin 1～2%, Borneolum Syntheticum 0.1～0.2%;
Medicine constituent optimum weight percentage ratio is:
Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae each 29.98%, the Flos Sophorae Immaturus, Radix Ilicis Pubescentis each 15%, Hirudo 7.5%, Calculus Bovis 0.75%, Moschus, Venenum Bufonis each 1.25%, stem and leaf of Radix Ginseng saponin 1.5%, Borneolum Syntheticum 0.15%;
(2) Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Ilicis Pubescentis are with 50～70% ethanol extractions 1～3 time, and extracting solution filters filtrate recycling ethanol, and concentrating under reduced pressure becomes paste, and drying is ground into fine powder, and is standby;
(3) Hirudo is refluxed 2～4 times with 60～80% ethanol extractions, and decompression recycling ethanol also is condensed into the thick paste shape, and cold drying is ground into fine powder, and is standby;
(4) Flos Sophorae Immaturus is with the limewater extraction rutin, and with acid for adjusting pH value 4～5, cooling precipitates, sucking filtration, and drying is ground into fine powder, and is standby;
(5) the Venenum Bufonis porphyrize is an impalpable powder, and Moschus, Borneolum Syntheticum, stem and leaf of Radix Ginseng saponin, bovine calculus powder are broken into fine powder, and mixing gets mixed powder, and is standby;
(6) get the fine powder mix homogeneously that (5) gained mixed powder adds (2), (3), (4) gained, get hybrid medicine, standby;
(7) with one or more of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188 or other suitable adjuvant, use with by arbitrary proportion, be heated to the hybrid medicine that adds (6) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70～100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, with the drop pill drop of molding to the greatest extent and remove coolant, dry coationg promptly;
(8) get the hybrid medicine of (6) gained, add an amount of adjuvant, mix homogeneously is granulated, and coating or coating are not made the micropill of diameter less than 2.5mm; Maybe, incapsulate, promptly get pellet capsule the micropill that makes;
Micropill or pellet capsule adjuvant are following one or more combinations or other suitable adjuvant, use with by arbitrary proportion: ethyl cellulose (EC), the polypropylene polysiloxanes, the wax class, Polyethylene Glycol (PEG), stearic acid, Lac, acrylic resin, polyvinyl alcohol, polyvinylpyrrolidone (PVP), methylcellulose, hydroxypropyl cellulose, cellulose propionate, the acrylic resin aqueous dispersion, the pseudo-latex of ethyl cellulose, cellulose acetate-phthalate (CAP) latex, polyphenyl dioctyl phthalate vinyl acetate (PVAP) aqueous dispersion, propylene glycol, glycerol, triacetin, acetyl list monoglyceride, phthalic acid ester, polyoxyethylene sorbitan monoleate, sodium lauryl sulphate, lactose, fructose, sucrose;
(9) get the hybrid medicine of (6) gained, add suitable adjuvant, mix homogeneously is suppressed or is dripped and makes soft capsule;
Adjuvant is one or more combinations or other suitable adjuvant of following material, uses with by arbitrary proportion: PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, tween.
Specific embodiments:
The present invention further specifies as follows in conjunction with specific embodiments:
A kind of Chinese medicine preparation of causing resuscitation with aromatic drugs promoting blood circulation to remove blood stasis, it is that main component is XUESHUANXINMAINING drop pill or micropill or the pellet capsule or the soft capsule of Rhizoma Chuanxiong, the Flos Sophorae Immaturus, Radix Salviae Miltiorrhizae, Hirudo, Radix Ilicis Pubescentis, Calculus Bovis, Moschus, stem and leaf of Radix Ginseng saponin, Borneolum Syntheticum, Venenum Bufonis;
Chinese medicine preparation energy causing resuscitation with aromatic drugs of the present invention, promoting blood circulation to remove blood stasis.Be mainly used in cerebral thrombosis, coronary heart disease, the angina pectoris person that belongs to the syndrome of qi stagnation and blood stasis.
The preparation method of Chinese medicine preparation of the present invention is:
(1) medicine constituent and weight consumption are as follows:
Rhizoma Chuanxiong, each 500g of Radix Salviae Miltiorrhizae, the Flos Sophorae Immaturus, each 250g of Radix Ilicis Pubescentis, Hirudo 125g, Calculus Bovis 12.5g, Moschus, each 1.25g of Venenum Bufonis, stem and leaf of Radix Ginseng saponin 25g, Borneolum Syntheticum 2.5g;
(2) Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Ilicis Pubescentis are with 60% ethanol extraction 2 times, and each 2～3 hours, extracting solution filtered, and merging filtrate reclaims ethanol, and concentrating under reduced pressure becomes to the thick paste of relative density 1.23～1.36 (60 ℃), is dried and crushed into fine powder, and is standby;
(3) Hirudo is refluxed 3 times with 70% ethanol extraction, and decompression recycling ethanol also is condensed into the thick paste shape, and 50～80 ℃ of dryings are ground into fine powder, and are standby;
(4) Flos Sophorae Immaturus is with the limewater extraction rutin, and with acid for adjusting pH value 4～5, cooling precipitates, sucking filtration, and drying is ground into fine powder, and is standby;
(5) the Venenum Bufonis porphyrize is an impalpable powder, and Moschus, Borneolum Syntheticum, stem and leaf of Radix Ginseng saponin, bovine calculus powder are broken into fine powder, and mixing gets mixed powder, and is standby;
(6) get the fine powder mix homogeneously that (5) gained mixed powder adds (2), (3), (4) gained, get hybrid medicine, standby;
(7) a kind of Chinese medicine preparation drop pill of causing resuscitation with aromatic drugs promoting blood circulation to remove blood stasis is the XUESHUANXINMAINING drop pill, its preparation method is a hybrid medicine of getting (6) gained, Polyethylene Glycol PEG6000 105g, stearic acid 36g, Poloxamer188 20g, treat to add above-mentioned hybrid medicine after Polyethylene Glycol PEG6000, stearic acid, Poloxamer188 are heated to whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 80 ℃, at heat-retaining condition by splashing in the liquid paraffin, be condensed into ball, with the drop pill drop of molding to the greatest extent and the erasing liquor paraffin body, cold drying promptly.
(8) a kind of Chinese medicine preparation micropill of causing resuscitation with aromatic drugs promoting blood circulation to remove blood stasis or pellet capsule are XUESHUANXINMAINING micropill or pellet capsule, its preparation method is a hybrid medicine of getting (6) gained, with 160g dextrin mix homogeneously, 5%PVP alcohol liquid is binding agent, at first preparing 60 purpose granules and make parent nucleus, is binding agent with 5%PVP alcohol liquid again, adds the mixed powder amplification and makes 40 purpose micropills, incapsulate, promptly get pellet capsule.
(9) a kind of Chinese medicine preparation soft capsule of causing resuscitation with aromatic drugs promoting blood circulation to remove blood stasis is the XUESHUANXINMAINING soft capsule, its preparation method is a hybrid medicine of getting (6) gained, behind water dissolution, the adding adjuvant is the combination of one or more different proportions in PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, the tween, suppresses or drips and make soft capsule.
Advantage of the present invention is:
Nonhygroscopic, bioavilability is high, controllability and good stability are conducive to improve curative effect.
Claims (3)
1, a kind of Chinese medicine preparation of causing resuscitation with aromatic drugs promoting blood circulation to remove blood stasis is characterized in that it is that main constituent is XUESHUANXINMAINING drop pill or micropill or the pellet capsule or the soft capsule of Rhizoma Chuanxiong, the Flos Sophorae Immaturus, Radix Salviae Miltiorrhizae, Hirudo, Radix Ilicis Pubescentis, Calculus Bovis, Moschus, stem and leaf of Radix Ginseng saponin, Borneolum Syntheticum, Venenum Bufonis.
2, a kind of preparation method of Chinese medicine preparation of causing resuscitation with aromatic drugs promoting blood circulation to remove blood stasis, it is XUESHUANXINMAINING drop pill or micropill or pellet capsule or preparation of soft capsule method, it is characterized in that:
(1) medicine constituent and percentage by weight consumption thereof are as follows:
Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae each 25～35%, the Flos Sophorae Immaturus, Radix Ilicis Pubescentis each 10～20%, Hirudo 5～10%, Calculus Bovis 0.5～1%, Moschus, Venenum Bufonis each 0.02～0.10%, stem and leaf of Radix Ginseng saponin 1～2%, Borneolum Syntheticum 0.1～0.2%;
(2) Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Ilicis Pubescentis are with 50～70% ethanol extractions 1～3 time, and extracting solution filters filtrate recycling ethanol, and concentrating under reduced pressure becomes paste, and drying is ground into fine powder, and is standby;
(3) Hirudo is refluxed 2～4 times with 60～80% ethanol extractions, and decompression recycling ethanol also is condensed into the thick paste shape, and cold drying is ground into fine powder, and is standby;
(4) Flos Sophorae Immaturus is with the limewater extraction rutin, and with acid for adjusting pH value 4～5, cooling precipitates, sucking filtration, and drying is ground into fine powder, and is standby;
(5) the Venenum Bufonis porphyrize is an impalpable powder, and Moschus, Borneolum Syntheticum, stem and leaf of Radix Ginseng saponin, bovine calculus powder are broken into fine powder, and mixing gets mixed powder, and is standby;
(6) get the fine powder mix homogeneously that (5) gained mixed powder adds (2), (3), (4) gained, get hybrid medicine, standby;
(7) after the hybrid medicine of getting (6) gained adds suitable adjuvant, make drop pill or micropill or pellet capsule or soft capsule;
The preparation method of its drop pill is: with one or more of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188 or other suitable adjuvant, use with by arbitrary proportion, be heated to the hybrid medicine that adds (6) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70-100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, with the drop pill drop of molding to the greatest extent and remove coolant, dry coationg promptly;
The preparation method of its micropill or pellet capsule is: get the hybrid medicine of (6) gained, add an amount of adjuvant, mix homogeneously is granulated, and coating or coating are not made the micropill of diameter less than 2.5mm; Maybe, incapsulate, promptly get pellet capsule the micropill that makes;
Micropill or pellet capsule adjuvant are following one or more combinations or other suitable adjuvant, use with by arbitrary proportion: ethyl cellulose (EC), the polypropylene polysiloxanes, the wax class, Polyethylene Glycol (PEG), stearic acid, Lac, acrylic resin, polyvinyl alcohol, polyvinylpyrrolidone (PVP), methylcellulose, hydroxypropyl cellulose, cellulose propionate, the acrylic resin aqueous dispersion, the pseudo-latex of ethyl cellulose, cellulose acetate-phthalate (CAP) latex, polyphenyl dioctyl phthalate vinyl acetate (PVAP) aqueous dispersion, propylene glycol, glycerol, triacetin, acetyl list monoglyceride, phthalic acid ester, polyoxyethylene sorbitan monoleate, sodium lauryl sulphate, lactose, fructose, sucrose;
Its preparation of soft capsule method is: get the hybrid medicine of (6) gained, add suitable adjuvant, mix homogeneously is suppressed or is dripped and makes soft capsule;
Adjuvant is one or more combinations or other suitable adjuvant of following material, uses with by arbitrary proportion: PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, tween.
3, the preparation method of the Chinese medicine preparation of a kind of causing resuscitation with aromatic drugs promoting blood circulation to remove blood stasis according to claim 2 is characterized in that the optimum weight percentage ratio of its main constituent is:
Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae each 29.98%, the Flos Sophorae Immaturus, Radix Ilicis Pubescentis each 15%, Hirudo 7.5%, Calculus Bovis 0.75%, Moschus, Venenum Bufonis each 1.25%, stem and leaf of Radix Ginseng saponin 1.5%, Borneolum Syntheticum 0.15%.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510031934 CN1733068A (en) | 2005-07-29 | 2005-07-29 | Chinese medicinal preparation for promoting blood circulation, dissipating blood stasis, inducing reuscitation with aromatics and preparation process thereof |
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| CN 200510031934 CN1733068A (en) | 2005-07-29 | 2005-07-29 | Chinese medicinal preparation for promoting blood circulation, dissipating blood stasis, inducing reuscitation with aromatics and preparation process thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342238B (en) * | 2008-08-27 | 2012-02-08 | 吉林华康药业股份有限公司 | Medicinal composition for treating cardiovascular and cerebrovascular diseases |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342238B (en) * | 2008-08-27 | 2012-02-08 | 吉林华康药业股份有限公司 | Medicinal composition for treating cardiovascular and cerebrovascular diseases |
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