CN101181572A - Method for preparing kaixiong shunqi wan - Google Patents
Method for preparing kaixiong shunqi wan Download PDFInfo
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- CN101181572A CN101181572A CNA2007101705777A CN200710170577A CN101181572A CN 101181572 A CN101181572 A CN 101181572A CN A2007101705777 A CNA2007101705777 A CN A2007101705777A CN 200710170577 A CN200710170577 A CN 200710170577A CN 101181572 A CN101181572 A CN 101181572A
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Abstract
The invention provides a method for preparing a digestion-promoting pill, including the following steps: crushing betelnut, fried morning glory seed, dried orange peel, costus root, officinal magnolia bark( processed with ginger), common burreed tuber ( processed with vinegar) and chinese honeylocust abnormal fruit respectively; mixing the powders; producing the mixed powder into grains and pressing the grains. By adopting pressing, the invention is simple in process and convenient in operation. The finished product is stable in quality, and the time of dissolvement is shortened by over 70 to 95 percent compared with the original digestion-promoting pills, so that the absorption of the medicine is quicker and the content of the magnolol is higher, thus solving the disadvantage that the pills made by water pill method are not even in size. The dose of the medicine is more accurate; meanwhile, the one-time finish rate is improved.
Description
Technical field
The present invention relates to a kind of preparation method that is used for the treatment of the Kaixiong Shunqi Wan of distending pain in the chest and hypochondrium, stomach wrist pain, belch vomiting and nausea, the indigestion and loss of appetite disease of lack of appetite.
Background technology
At present, the Kaixiong Shunqi Wan that adopts Semen Arecae, Semen Pharbitidis (stir-fry), Pericarpium Citri Reticulatae, the Radix Aucklandiae, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed), rhizoma sparganic (processed with vinegar), Rhizoma Curcumae (processed with vinegar) and Fructus Gleditsiae Abnormalis 8 flavor medical materials to be prepared into, for light brown to the brown watered pill, having removing food stagnancyization stagnates, the function of promoting the circulation of QI to relieve pain, the distending pain in the chest and hypochondrium, stomach wrist pain, belch vomiting and nausea, the lack of appetite that are used for due to the stagnation of QI dyspepsia are indigestion and loss of appetite.
The watered pill is a kind of traditional Chinese medicine preparation form, normally Chinese crude drug is ground into to adopt behind the fine powder agitation procedure to make.Traditional agitation procedure production process comprises the steps: to adopt common crushing technology to be ground into fine powder medical material, and water molding, increasing are sieved repeatedly, then capping, drying, polishing.Whole process complexity, loaded down with trivial details, labor intensity is big, is difficult to operation, the one-pass finished qualification rate is low, and ball heavily differs greatly, and also occurs molten diffusing overlong time, the nonabsorbable phenomenon of medicine sometimes, not only brought inconvenience, influenced product quality, also influenced therapeutic effect to production.
Summary of the invention
The preparation method that the purpose of this invention is to provide a kind of new Kaixiong Shunqi Wan is to overcome the defective that prior art exists.
Preparation method of the present invention comprises the steps:
With Semen Arecae, Semen Pharbitidis (stir-fry), Pericarpium Citri Reticulatae, the Radix Aucklandiae, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed), rhizoma sparganic (processed with vinegar), Rhizoma Curcumae (processed with vinegar) and Fructus Gleditsiae Abnormalis 8 flavor medical materials, pulverize separately becomes fine powder, mixing, then, granulates pelleting;
Preferably, the fine powder after pulverizing is added adhesive, make granule, in 50～80 ℃ of dryings, granulate then, adds lubricant, is pressed into ball, promptly;
Preferably, with Semen Arecae, Semen Pharbitidis (stir-fry), Pericarpium Citri Reticulatae, the Radix Aucklandiae, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed), rhizoma sparganic (processed with vinegar), Rhizoma Curcumae (processed with vinegar) and Fructus Gleditsiae Abnormalis 8 flavor medical materials, pulverize separately becomes 80～250 purpose fine powders;
Preferably, said adhesive is selected from more than one in water or the ethanol, and the adding weight of adhesive is 20～80% of said fine powder;
After raw material carried out micronizing, the cell wall rupture of most cells, intracellular effective ingredient does not need directly to contact with medicine-feeding part by the cell wall barrier.Because it is little to pulverize diameter of aspirin particle, specific surface area is very big, very easily is adsorbed on the small bowel to be absorbed by small bowel, has improved the infiltration rate and the content of effective ingredient greatly; On the other hand, micropowder and medicine-feeding part contact area are big, have prolonged the medicine holdup time in vivo, and the absorbtivity of medicine also significantly increases;
Preferred magnesium stearate of said lubricant or silicon dioxide;
The parts by weight of said eight flavor medical materials are as follows:
250～350 parts of Semen Arecaes, 300～400 parts of Semen Pharbitidiss (stir-fry), 50～100 parts of Pericarpium Citri Reticulataes, 50～100 parts of the Radix Aucklandiae, 50～100 parts of Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed), 100～150 parts of rhizoma sparganic (processed with vinegar), 100～150 parts of Rhizoma Curcumae (processed with vinegar), 50～100 parts of Fructus Gleditsiae Abnormalis.
Preferably, the parts by weight of 8 flavor medical materials are as follows:
300 parts of Semen Arecaes, 400 parts of Semen Pharbitidiss (stir-fry), 1 00 parts of Pericarpium Citri Reticulataes, 75 parts of the Radix Aucklandiae, 100 parts of Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed), 100 parts of rhizoma sparganic (processed with vinegar), 100 parts of Rhizoma Curcumae (processed with vinegar), 50 parts of Fructus Gleditsiae Abnormalis.
What the present invention adopted is pressing, technology is simple, easy to operate, the constant product quality of making, more former Kaixiong Shunqi Wan of molten diffusing time shortens more than 70～95%, makes that drug absorption is faster, the content of magnolol and honokiol is higher, solved the uneven problem of agitation procedure pill size, make the dosage of medicine more accurate, simultaneously, also improved the one-pass finished rate.
As seen, adopt the more former Kaixiong Shunqi Wan of molten diffusing time of Kaixiong Shunqi Wan after this method prepares to shorten more than 70～95%, greatly improved the product curative effect.Breastization stagnates for having out, the Kaixiong Shunqi Wan of promoting the circulation of QI to relieve pain, has very large clinical meaning, social meaning, also has good economic benefit and application prospect simultaneously.
Below in conjunction with embodiment the inventive method is further described.
The specific embodiment
Embodiment 1
1, batching
Take by weighing by product prescription proportioning: Semen Arecae 300g, Semen Pharbitidis (stir-fry) 400g, Pericarpium Citri Reticulatae 100g, Radix Aucklandiae 75g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 100g, rhizoma sparganic (processed with vinegar) 100g, Rhizoma Curcumae (processed with vinegar) 100g, Fructus Gleditsiae Abnormalis 50g be totally eight flavor Chinese crude drugs, and be standby;
2, pulverize, mix
After the weighing 8 flavor Chinese crude drug is carried out micronizing become 250 purpose fine powders, mix homogeneously, standby;
3, granulate
Adopt water to make adhesive the fine powder after pulverizing, the addition of water is 30% of a fine powder weight, makes granule, carries out drying in 60 ℃, and granulate is standby;
4, pelleting
Magnesium stearate with the adding of the granule behind granulate particle weight 0.5% is pressed into ball with punch die, promptly.
Adopt " method of the quality standard regulation of the XIANGSHA YANGWEI WAN that Chinese pharmacopoeia is recorded detects, and the Kaixiong Shunqi Wan some projects index that this method and general method for making are made is compared as follows table:
| Project | Agitation procedure | This method |
| Dissolve scattered time limit (branch) | 38 | 2.0 |
| Limit test of weight variation (± %) | 6.4 | 4.3 |
| Magnolol and honokiol content (mg/g) | 1.1913 | 1.3446 |
| One-pass finished rate (%) | 86.4 | 97.3 |
| The outward appearance uniformity | Not too even | Evenly |
| Labor strength | Bigger | Medium on the low side |
| Operability | Numerous and diverse | Easy economy |
Embodiment 2
1, batching
Take by weighing by product prescription proportioning: Semen Arecae 300g, Semen Pharbitidis (stir-fry) 400g, Pericarpium Citri Reticulatae 100g, Radix Aucklandiae 75g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 100g, rhizoma sparganic (processed with vinegar) 100g, Rhizoma Curcumae (processed with vinegar) 100g, Fructus Gleditsiae Abnormalis 50g be totally eight flavor Chinese crude drugs, and be standby;
2, pulverize, mix
After the weighing 8 flavor Chinese crude drug is carried out micronizing become 150 purpose fine powders, mix homogeneously, standby;
3, granulate
Adopt ethanol to make adhesive the fine powder after pulverizing, the addition of water is 75% of a fine powder weight, makes granule, carries out drying in 50 ℃, and granulate is standby;
4, pelleting
Silicon dioxide with the adding of the granule behind granulate particle weight 0.3% is pressed into ball with punch die, promptly.
Adopt " method of the quality standard regulation of the XIANGSHA YANGWEI WAN that Chinese pharmacopoeia is recorded detects, and the Kaixiong Shunqi Wan some projects index that this method and general method for making are made is compared as follows table:
| Project | Agitation procedure | This method |
| Dissolve scattered time limit (branch) | 38 | 2.2 |
| Limit test of weight variation (± %) | 6.4 | 3.1 |
| Magnolol and honokiol content (mg/g) | 1.1913 | 1.2346 |
| One-pass finished rate (%) | 86.4 | 96.7 |
| The outward appearance uniformity | Not too even | Evenly |
| Labor strength | Bigger | Medium on the low side |
| Operability | Numerous and diverse | Easy economy |
Claims (9)
1. prepare the method for Kaixiong Shunqi Wan, it is characterized in that, comprise the steps:
With Semen Arecae, Semen Pharbitidis (stir-fry), Pericarpium Citri Reticulatae, the Radix Aucklandiae, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed), rhizoma sparganic (processed with vinegar), Rhizoma Curcumae (processed with vinegar) and Fructus Gleditsiae Abnormalis eight flavor medical materials, pulverize separately becomes fine powder, mixing, then, granulates pelleting.
2. method according to claim 1 is characterized in that, the fine powder after pulverizing is added adhesive, makes granule, and in 50～80 ℃ of dryings, granulate then, adds lubricant, is pressed into ball.
3. method according to claim 1 is characterized in that, said lubricant is the mixture of magnesium stearate or silicon dioxide or magnesium stearate and silicon dioxide.
4. method according to claim 1 is characterized in that said adhesive is selected from more than one in water or the ethanol, and the adding weight of adhesive is 20～80% of said fine powder.
5. according to each described method of claim 1～4, it is characterized in that with Semen Arecae, Semen Pharbitidis (stir-fry), Pericarpium Citri Reticulatae, the Radix Aucklandiae, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed), rhizoma sparganic (processed with vinegar), Rhizoma Curcumae (processed with vinegar) and Fructus Gleditsiae Abnormalis 8 flavor medical materials, pulverize separately becomes 80～250 purpose fine powders.
6. according to each described method of claim 1～4, it is characterized in that the parts by weight of said eight flavor medical materials are as follows:
250～350 parts of Semen Arecaes, 300～400 parts of Semen Pharbitidiss (stir-fry), 50～100 parts of Pericarpium Citri Reticulataes, 50～100 parts of the Radix Aucklandiae, 50～100 parts of Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed), 100～150 parts of rhizoma sparganic (processed with vinegar), 100～150 parts of Rhizoma Curcumae (processed with vinegar), 50～100 parts of Fructus Gleditsiae Abnormalis.
7. method according to claim 6 is characterized in that, the parts by weight of eight flavor medical materials are as follows: 300 parts of Semen Arecaes, 400 parts of Semen Pharbitidiss (stir-fry), 100 parts of Pericarpium Citri Reticulataes, 75 parts of the Radix Aucklandiae, 100 parts of Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed), 100 parts of rhizoma sparganic (processed with vinegar), 100 parts of Rhizoma Curcumae (processed with vinegar), 50 parts of Fructus Gleditsiae Abnormalis.
8. method according to claim 6, it is characterized in that, the parts by weight of said eight flavor medical materials are as follows: 250～350 parts of Semen Arecaes, 300～400 parts of Semen Pharbitidiss (stir-fry), 50～100 parts of Pericarpium Citri Reticulataes, 50～100 parts of the Radix Aucklandiae, 50～100 parts of Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed), 100～150 parts of rhizoma sparganic (processed with vinegar), 100～150 parts of Rhizoma Curcumae (processed with vinegar), 50～100 parts of Fructus Gleditsiae Abnormalis.
9. method according to claim 8 is characterized in that, the parts by weight of eight flavor medical materials are as follows: 300 parts of Semen Arecaes, 400 parts of Semen Pharbitidiss (stir-fry), 100 parts of Pericarpium Citri Reticulataes, 75 parts of the Radix Aucklandiae, 100 parts of Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed), 100 parts of rhizoma sparganic (processed with vinegar), 100 parts of Rhizoma Curcumae (processed with vinegar), 50 parts of Fructus Gleditsiae Abnormalis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101705777A CN101181572A (en) | 2007-11-19 | 2007-11-19 | Method for preparing kaixiong shunqi wan |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101705777A CN101181572A (en) | 2007-11-19 | 2007-11-19 | Method for preparing kaixiong shunqi wan |
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| CN101181572A true CN101181572A (en) | 2008-05-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2007101705777A Pending CN101181572A (en) | 2007-11-19 | 2007-11-19 | Method for preparing kaixiong shunqi wan |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101797365A (en) * | 2010-04-21 | 2010-08-11 | 浙江维康药业有限公司 | Preparation technology of Kaixiong Shunqi Jiaonang |
| CN104398977A (en) * | 2014-11-04 | 2015-03-11 | 林素霞 | Traditional Chinese medicine treating functional dyspepsia |
| CN108671206A (en) * | 2018-08-09 | 2018-10-19 | 河南润弘本草制药有限公司 | Pleasant digestant Chinese medicine |
-
2007
- 2007-11-19 CN CNA2007101705777A patent/CN101181572A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101797365A (en) * | 2010-04-21 | 2010-08-11 | 浙江维康药业有限公司 | Preparation technology of Kaixiong Shunqi Jiaonang |
| CN101797365B (en) * | 2010-04-21 | 2011-09-28 | 浙江维康药业有限公司 | Preparation technology of Kaixiong Shunqi Jiaonang |
| CN104398977A (en) * | 2014-11-04 | 2015-03-11 | 林素霞 | Traditional Chinese medicine treating functional dyspepsia |
| CN108671206A (en) * | 2018-08-09 | 2018-10-19 | 河南润弘本草制药有限公司 | Pleasant digestant Chinese medicine |
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Open date: 20080521 |