CN104398977A - Traditional Chinese medicine treating functional dyspepsia - Google Patents
Traditional Chinese medicine treating functional dyspepsia Download PDFInfo
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- CN104398977A CN104398977A CN201410645308.1A CN201410645308A CN104398977A CN 104398977 A CN104398977 A CN 104398977A CN 201410645308 A CN201410645308 A CN 201410645308A CN 104398977 A CN104398977 A CN 104398977A
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Abstract
A traditional Chinese medicine treating functional dyspepsia is prepared from the following raw medicinal materials in parts by weight: 7 parts of common burreed rhizome, 3 parts of rhizoma curcumae, 9 parts of bark of engelhardtia roxburghiana, 5 parts of swertia pseudochinensis, 6 parts of cortex magnoliae officinalis, 14 parts of root of longstem hawksbeard, and 15 parts of fructus hordei germinatus. Clinic experiments prove that the traditional Chinese medicine is capable of safely effectively treating functional dyspepsia.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine being used for the treatment of functional dyspepsia.
Background technology
Functional dyspepsia (FD), also known as dyspepsia, refers to have the malaise symptoms such as upper abdominal pain, big belly, early full, belch, inappetence, Nausea and vomiting, gets rid of the one group of clinical syndrome causing the organic disease of above-mentioned symptom on inspection.Sustainable or the recurrent exerbation of symptom, accumulative more than 12 weeks in course of disease December more than month or in the past.FD is modal a kind of functional gastrointestinal disorder clinically.At present, western medical treatment without specific drug, mainly experiential therapy, the medicine of such as gastric acid secretion inhibiting, short digestive tract power reinforcing medicine (domperidone, itopride etc.) and Helicobacter pylori eradication for treatment.Modern Chinese medicine research is thought that primary disease is many and is not relaxed because of feelings will, eating and drinking without temperance, overstrain, affection of exogenous damp etc. are multifactor wherein not to relax the most common with feelings will especially, and cause depression of liver-QI the liver failing to maintain the normal flow of QI, stagnation of liver-QI takes advantage of spleen, hyperactive liver-QI attacking the stomach makes dysfunction of the spleen in transportation, and taste ascending or descending movement of vital Qi is not normal, caused by middle burnt painful abdominal mass plug is obstructed.
Medical material present Research involved in the present invention is as follows:
The tuber that Rhizoma Sparganii [another name] RHZOMA SPARGANII, red Rhizoma typhae, RHIZOMA SPARGANII [source] are Sparganiaceae plant rhizoma scirpi, spire rhizoma scirpi, little rhizoma scirpi.Autumn, season in winter two all can gather, and after taking tuber, remove stem and leaf and fibrous root, and clean, crust of pruning, dries.[habitats distribution] is distributed in the ground such as northeast, North China, East China, southwest and Shaanxi, Ningxia, Gansu, Henan, Hubei, Hunan.[nature and flavor] liver; Spleen channel.The circulation of qi promoting of [function cures mainly] removing blood stasis; Removing food stagnancy pain relieving.Primary symptom abdominal mass mass in the abdomen; The stagnant amenorrhea of the stasis of blood; Dysmenorrhea; Food stagnation distending pain; Traumatic pain.[usage and dosage] takes orally: decoct soup, 5-10g; Or enter ball, loose.[extracts] " China's book on Chinese herbal medicine "
The rhizome that Rhizoma Curcumae [another name] Rhizoma Curcumae, fluffy medicine, Rhizoma Curcumae, Guang Mao, fluffy art, blue or green Rhizoma Zingiberis Recens, Qiang seven [source] are zingiberaceous plant Rhizoma Curcumae, Guangxi zedoary and RADIX CURCUMAE.In 12 months, the last ten-days period, when aerial parts is withered, excavate root, the earth on removing rhizome, cleans, and puts and to steam in pot or to boil about 15min, dry or dry, hit fibrous root.Also rhizome can be put into clear water to soak, pick up, drain the water, run through, shave, dry or dry.[nature and flavor] acrid in the mouth; Bitter; Warm in nature.[return through] returns liver, spleen channel.[function cures mainly] circulation of qi promoting removing blood stasis; Removing food stagnancy pain relieving.Main vim and vigour are pained; Eating accumulation; Abdominal distention; Amenorrhea due to stagnation of blood; Dysmenorrhea; Lump in the abdomen tumor mass in the abdomen; Traumatic injury.[usage and dosage] takes orally: decoct soup, 3-10g; Or enter ball, loose.External: appropriate, decocts soup and washes; Or grind into powder and dress.The how raw use of promoting the circulation of QI to relieve pain, removing blood stasis should be fried by vinegar.[extracts] " China's book on Chinese herbal medicine "
The bark that Engelhardtia roxburghiana skin [another name] Magnolia delavayi Franch., false beautiful osmanthus [source] are juglandaceae plant Engelhardtia roxburghiana.Summer, autumn strip bark, clean, using fresh herb or dry.[nature and flavor] micro-hardship; Pungent; Property is put down.[function cures mainly] circulation of qi promoting; Removing dampness; Intestinal stasis relieving.Main taste humidity hysteresis; Gastral cavity abdominal distention is vexed; Have loose bowels.[usage and dosage] takes orally: decoct soup, 6-15g.[extracts] " China's book on Chinese herbal medicine "
Tumor hair Herba Swertiae bimaculatae [another name] Herba Swertiae bimaculatae, when medicine, pale reddish brown when medicine [source] herb that is gentianaceae plant tumor hair Herba Swertiae bimaculatae.Summer, autumn gather, and clean, dry.[nature and flavor] are bitter; Cold in nature.[return through] liver; Stomach; Large intestine channel.[function cures mainly] eliminating fire and detoxication; Dampness removing; Spleen invigorating.Main jaundice due to damp-heat; Dysentery; Gastritis; Dyspepsia; Acute catarrhal conjunctivitis; Toothache; Aphtha; Sore swells and ache.[usage and dosage] takes orally: decoct soup, 3-10g; Or grind into powder and take after mixing it with water.External: appropriate, mashes external application; Or extracting juice is coated with outward.[extracts] " China's book on Chinese herbal medicine "
Bark, branch skin and root bark that Cortex Magnoliae Officinalis [another name] pachydermia, pipe, magnolia hypoleuca, strong Piao, Cortex Magnoliae Officinalis, CORTEX MAGNOLIAE OFFICINALIS [source] are Magnoliacea plant Cortex Magnoliae Officinalis and Mount Lushan Cortex Magnoliae Officinalis.Field planting can chop at a tree peeling for more than 20 years, should carry out in peak of growing season in 4 ~ August.Dry after root bark and branch skin Directly Dried in Shadow or reel, claim root Piao and branch plain; In micromicro band girdle or bar stripping after, reel put in boiling water scald soft after, embedding dark and damp place diaphoresis.Treat that Intradermal side or transverse section all become puce or sepia, and during existing glossy or gloss, every section of bark is rolled into the bitubular, slights with bamboo and tighten, cut neat two ends, tan by the sun dry.[nature and flavor] are bitter; Pungent; Warm in nature.[return through] spleen; Stomach; Large intestine channel.[function cures mainly] circulation of qi promoting removing food stagnancy; Dampness is except full; Lowering the adverse QI to relieve asthma.Main stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant stops up QI rising in reverse order; Fullness in the chest is breathed with cough.[usage and dosage] takes orally: decoct soup, 3-10g; Or enter ball, loose.[extracts] " China's book on Chinese herbal medicine "
Radix Crepidis elongatae [source] this product is river, feverfew Yunnan Radix Crepidis elongatae, the herb of Herba Crepidis croceae and long shoot Radix Crepidis elongatae or root.Summer, autumn adopt herb, and autumn adopts root, clean, using fresh herb or dry.[nature and flavor] bitter in the mouth; Sweet; Cool in nature.[function cures mainly] relieving cough and asthma; Strengthening the spleen to promote digestion; Stimulating milk secretion.Main bronchus is scorching; Pulmonary tuberculosis; Infantile malnutrition; Breast is splashed deficiency.[usage and dosage] takes orally: decoct soup, 15-30g; Or enter cream, ball.External: appropriate, endures cream coating.[extracts] " China's book on Chinese herbal medicine "
Fructus Hordei Germinatus [another name] Fructus Hordei Vulgaris tiller, wheat tiller, Fructus Hordei Vulgaris hair, Fructus Hordei Germinatus [source] this product are the germination caryopsis of grass Fructus Hordei Vulgaris.[nature and flavor] are sweet; Flat.[return through] spleen; Stomach warp.[function cures mainly] promoting digestion and removing stagnation; Galactopoiesis.Staple food is long-pending not to disappear; Abdominal distention is had loose bowels; Feel sick and tell; Inappetence; Milk smoulders; Distending pain of the breast.[usage and dosage] takes orally: decoct soup, 10-15g, heavy dose of available 30-120g; Or enter ball, loose.[extracts] " China's book on Chinese herbal medicine "
Summary of the invention
The present invention aims to provide a kind of Chinese medicine being used for the treatment of functional dyspepsia, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing functional dyspepsia.
In order to achieve the above object, the present invention is by the following technical solutions:
Be used for the treatment of a Chinese medicine for functional dyspepsia, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Rhizoma Sparganii 7 parts, Rhizoma Curcumae 3 parts, Engelhardtia roxburghiana skin 9 parts, tumor hair Herba Swertiae bimaculatae 5 parts, Cortex Magnoliae Officinalis 6 parts, Radix Crepidis elongatae 14 parts, 15 parts, Fructus Hordei Germinatus.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, clinical data
1.1 patient's physical data
Inventor in JIUYUE, 2010 ~ 2013 collect patients with functional dyspepsia 86 example of outpatient clinic altogether between year April, all meet functional dyspepsia diagnostic criteria.Use DPS software to produce random sequence and the experimenter entering group is divided into treatment group 43 example at random, matched group 43 example.After this test terminates 4 week course for the treatment of, have 4 examples (test group 1 example, matched group 3 example) lost to follow-up.Treatment group 1 example exited in the 2nd week because of burst acute appendicitis operative treatment; Matched group 2 example identifies oneself symptom without improvement, the 2nd week backed off after random after taking medicine, and another routine matched group is lost to follow-up, therefore finally completes patient treatment group 42 example of test, matched group 40 example, two groups of Gender when age group prejudice table 1, tables 2 completing experiment.
A table 1 liang group Gender situation compares (example)
Through X 2 test, P=0.279 > 0.05, namely two groups of sex there was no significant differences, have comparability.
A table 2 liang group patient age situation compares (example)
Two groups of ages are nonnormal distribution, therefore adopt nonparametric rank test, and inspected number z=-1.078, P=0.306 > 0.05, namely two groups of ages compare there was no significant difference, have comparability.
1.2 diagnostic criteria
1.2.1 Western medicine diagnose standard
Meet the Rome III diagnostic criteria of functional gastrointestinal disorder: functional dyspepsia must comprise (1) 1 or many: a. post-prandial fullness discomfort below; B. early full sense; C. upper abdominal pain; D. upper abdomen burn feeling; And there is no the evidence of the organic disease can explaining above-mentioned symptom (2).Before diagnosis, symptom occurs at least 6 months, within nearly 3 months, meets above standard.
1.2.2 tcm diagnosis standard
With reference to " new Chinese medicine treats dyspeptic guideline of clinical investigations " syndrome of incoordination between liver and stomach in " combination of Chinese and Western medicine diagnosis and treatment project (draft) of functional dyspepsia " hyperactive liver-QI attacking the stomach card and 2002 " new Chinese medicine guideline of clinical investigations ":
Primary symptom: gastral cavilty distension, pain; Sighing frequently; Loss of appetite; Often increase the weight of because of emotional factors, pale tongue with white fur, stringy pulse.
Secondary disease: early full; Belch pantothenic acid, heartburn; Nauseating tending to vomit; Irritable.
1.3 case inclusive criterias
1. above-mentioned Western medicine diagnose standard is met;
2. above-mentioned tcm diagnosis standard is met;
3. indigestion symptom is not alleviated after defecation, or the change of dyspeptic outbreak and times of defecation or character has nothing to do, and namely gets rid of irritable bowel syndrome;
4. the age is between 18-65 year;
5. test and get rid of gastric organic disease through gastroscopy in first 4 weeks;
6. liver, biliary tract disease are got rid of in ultrasonic examination;
7. testing in first 72 hours has stopped using affects the spasmolytic of this test, anticholinergic agent and other medicine for stomach dynamic;
8. have a mind to coordinate this to observe therapist.
1.4 Excluded cases standards
1. do not meet inclusive criteria, or participate in the patient of other drug clinical experiment;
2. merge gastric organic disease, as peptic ulcer is shown in gastroscopy, rotten to the corn and hemorrhage etc., pathologic finding finds gastric mucosa atrophy person;
3. gastroesophageal reflux disease, irritable bowel syndrome etc. is merged;
4. gestation or women breast-feeding their children, allergic constitution and to this medicine allergy sufferers;
5. the severe primary disease patients such as cardiovascular and cerebrovascular vessel, liver, kidney and blood system are merged;
6. the patient such as psychosis, senile dementia.
1.5 cases come off standard
Screen the qualified experimenter entering clinical research, no matter any reason exits, as long as do not complete the treatment cycle of research approach, is the case that comes off; Less than the course for the treatment of, but clinical symptoms spontaneous recovery person is as coming off case.
1.6 cases reject standard
1., after case is included in, the person that do not meet inclusive criteria is found;
2. after case is included in, the person that do not use experimental drug;
3. patient compliance is poor, not by regulation medication, adds voluntarily with or uses other medicines instead, cannot judge curative effect person;
4. without any data person after including in.
2, test method
2.1 Therapeutic Method
The decoct that the oral the present invention for the treatment of group obtains according to specific embodiment 1, every day 3 times.4 weeks courses for the treatment of.
The oral domperidone of matched group, uses according to its description, 4 weeks courses for the treatment of.
Patient keeps happy at duration of test, avoids fatigue, avoids the edible irritable food such as pungent, greasy, cold, avoids the stimulations such as strong tea, cigarette, wine as far as possible.
Except the medicine that test is used, viewing duration cuts out other drug and other non-drug therapy relevant to primary disease for the treatment of functional dyspepsia.Must the other diseases of drug administration as merged, need in the number of times of research medical history record medicine name, consumption, usage and medication and time.
Observation index adopts observation of scoring, and before treatment, after treatment, once, record weekly once in therapeutic process, the course for the treatment of is 4 weeks to each record.
3, criterion of therapeutical effect and therapeutic outcome
3.1 tcm symptoms quantize ranking criterion
Work out TCM syndrome standards of grading with reference to 2002 " new Chinese medicine guideline of clinical investigations ", tcm symptom be light, in, heavy degree standards of grading are in table 3.Respectively each symptom is quantized.Each integration sum is tcm symptom total mark.
Table 3 tcm symptom is light, in, heavy degree standards of grading
3.2 efficacy assessment standard
Recovery from illness: clinical symptoms, sign disappear or substantially disappear, syndrome integral reduces >=95%;
Effective: clinical symptoms, sign are obviously improved, syndrome integral reduces >=70%;
Effective: clinical symptoms, sign all take a favorable turn, syndrome integral reduces >=30%;
Invalid: clinical syndrome, sign are all not improved, even increase the weight of, syndrome integral reduces < 30%
Total effective rate=(recovery from illness+effective+effectively)/total number of cases * 100%
TCM symptom score result before and after 3.3 liang of group treatments
Record weekly 1 each TCM symptom score in therapeutic process, the course for the treatment of is 4 weeks, calculates each total mark in table 4.
TCM symptom score (mean ± SD) in table 4 liang group therapeutic process
Treatment group with after treatment of control group with compare P in group before treatment and be respectively 0.941 and 0.889, all be greater than 0.05, compare P=0.359 > 0.05 between group after two groups of treatments, namely two groups of curative effects have significant difference, and treatment group curative effect is significantly better than matched group.
3.3 clinical total effectses
After two groups of treatments, clinical total effects compares in table 5.
The table 5 liang clinical total effects of group compares
Treatment group compares with matched group, through X 2 test P=0.236 > 0.05, namely the total effective rate for the treatment of group is significantly better than matched group, and it is high and not easily recur that visible the present invention is used for the treatment of functional dyspepsia cure rate, has the value applied.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Specific embodiment 1
Take: Rhizoma Sparganii 7 grams, Rhizoma Curcumae 3 grams, Engelhardtia roxburghiana skin 9 grams, tumor hair Herba Swertiae bimaculatae 5 grams, Cortex Magnoliae Officinalis 6 grams, Radix Crepidis elongatae 14 grams, 15 grams, Fructus Hordei Germinatus; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.
Be used for the treatment of functional dyspepsia.Oral, every bu morning, noon and afternoon take for three times.
Specific embodiment 2
Take: Rhizoma Sparganii 7 grams, Rhizoma Curcumae 3 grams, Engelhardtia roxburghiana skin 9 grams, tumor hair Herba Swertiae bimaculatae 5 grams, Cortex Magnoliae Officinalis 6 grams, Radix Crepidis elongatae 14 grams, 15 grams, Fructus Hordei Germinatus; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of functional dyspepsia.Oral, every bu morning, noon and afternoon take for three times.
Specific embodiment 3
Take: Rhizoma Sparganii 7 grams, Rhizoma Curcumae 3 grams, Engelhardtia roxburghiana skin 9 grams, tumor hair Herba Swertiae bimaculatae 5 grams, Cortex Magnoliae Officinalis 6 grams, Radix Crepidis elongatae 14 grams, 15 grams, Fructus Hordei Germinatus; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.
Be used for the treatment of functional dyspepsia.Oral, every bu morning, noon and afternoon take for three times.
Claims (4)
1. be used for the treatment of a Chinese medicine for functional dyspepsia, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Rhizoma Sparganii 7 parts, Rhizoma Curcumae 3 parts, Engelhardtia roxburghiana skin 9 parts, tumor hair Herba Swertiae bimaculatae 5 parts, Cortex Magnoliae Officinalis 6 parts, Radix Crepidis elongatae 14 parts, 15 parts, Fructus Hordei Germinatus.
2. a kind of Chinese medicine being used for the treatment of functional dyspepsia as claimed in claim 1, it is characterized in that, its preparation method is: take: Rhizoma Sparganii 7 parts, Rhizoma Curcumae 3 parts, Engelhardtia roxburghiana skin 9 parts, tumor hair Herba Swertiae bimaculatae 5 parts, Cortex Magnoliae Officinalis 6 parts, Radix Crepidis elongatae 14 parts, 15 parts, Fructus Hordei Germinatus; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 parts, obtains decoct; Above-mentioned part all refers to weight portion.
3. a kind of Chinese medicine being used for the treatment of functional dyspepsia as claimed in claim 1, it is characterized in that, its preparation method is: take: Rhizoma Sparganii 7 parts, Rhizoma Curcumae 3 parts, Engelhardtia roxburghiana skin 9 parts, tumor hair Herba Swertiae bimaculatae 5 parts, Cortex Magnoliae Officinalis 6 parts, Radix Crepidis elongatae 14 parts, 15 parts, Fructus Hordei Germinatus; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, obtains powder; Above-mentioned part all refers to weight portion.
4. a kind of Chinese medicine being used for the treatment of functional dyspepsia as claimed in claim 1, it is characterized in that, its preparation method is: take: Rhizoma Sparganii 7 parts, Rhizoma Curcumae 3 parts, Engelhardtia roxburghiana skin 9 parts, tumor hair Herba Swertiae bimaculatae 5 parts, Cortex Magnoliae Officinalis 6 parts, Radix Crepidis elongatae 14 parts, 15 parts, Fructus Hordei Germinatus; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, obtains capsule; Above-mentioned part all refers to weight portion.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104984187A (en) * | 2015-06-18 | 2015-10-21 | 钟海林 | Traditional Chinese medicine used for treating chronic gastritis |
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