CN102000295B - Chinese material medical preparation used for treating gastritis and gastric ulcer and preparation method thereof - Google Patents
Chinese material medical preparation used for treating gastritis and gastric ulcer and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicine composition and a preparation method thereof, in particular to a Chinese material medical preparation used for treating gastritis and gastric ulcer and a preparation method thereof. The traditional Chinese medical herbs are not easy for compatibility and combination and have high price, so the treatment cost is relatively high. The Chinese material medical preparation used for treating gastritis and gastric ulcer comprises the following raw materials in parts by weight: 134-154 parts of nutgrass galingale rhizome, 86-106 parts of perilla nankinensis decue, 86-106 parts of radix glycyrrhizae preparata, 134-154 parts of fructus citri, 134-154 parts of officinal magnolia bark, 150-170 parts of round cardamom fruit (fried), 150-170 parts of amomum fruit (fried), 134-154g of rhizoma polygonati and 182-202 parts of radix astragali preparata. The preparation method is a conventional pill preparation method. The Chinese material medical preparation has treatment effective rate reaching 100 percent and cure rate reaching above 98 percent, and has no resistance to drugs and drug tolerance.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically is a kind of Chinese medicine preparation that is used to treat gastritis, gastric ulcer and preparation method thereof.
Background technology
Chronic gastritis, atrophic gastritis and gastric ulcer are digestive system commonly encountered diseases, frequently-occurring disease; Belong to sick categories such as the traditional Chinese medical science " stomach painful abdominal mass ", " gastric abscess ", " stomachache due to hyperactive liver-QI attacking the stomach ", " singultus ", " acid regurgitation "; " epigastric pain ", " peratodynia ", " stomachache ", " the hungry full consumptive disease " etc. of being called among the people more; This type of digestive system commonly encountered diseases has caused great threat to health; It not only brings long-term misery to patient, and has a strong impact on people's existence and quality of life, causes heavy burden for society, family.At present, still few at this type of sick Chinese traditional patent formulation preparation of commercially available treatment, particularly still less to the compound Chinese medicinal preparation of primary disease energy-stagnation stomachache card person exploitation; And treatment needs multiple compatibility of drugs or Chinese medicine cost higher; As disclosing day is on October 26th, 2005, a kind of medicine of treating gastritis and gastric ulcer that publication number CN 1686308A announces and preparation method thereof, and it is combined by 22 flavor major ingredient Chinese medicines and supplementary product compatibility; Prescription is comparatively numerous and diverse, and preparation technology is comparatively complicated; Open day is on May 28th, 2008, and publication number is the treatment acute chronic gastroenteritis of CN 101185717A announcement and the Chinese medicine of intestine gastric ulcer, is made up of 13 flavor Chinese medicines; Wherein contain rare Chinese medicines such as Radix Ginseng; Cost an arm and a leg, be difficult for compatible combination, so its treatment cost is higher relatively.
Summary of the invention
The object of the invention is to provide a kind of Chinese medicine preparation that is used to treat gastritis, gastric ulcer and preparation method thereof; The present invention's compatibility on combination ancient Chinese medicine and modern clinical basis forms; Not only the prescription compatibility is simple for it; And the Chinese medicine relative price of respectively distinguishing the flavor of is cheap, and the patient is acceptant, is suitable for large range promotion use.
For realizing above-mentioned purpose, the technical scheme that the present invention adopts is:
A kind of Chinese medicine preparation that is used to treat gastritis, gastric ulcer is characterized in that: raw material composition and the weight proportion thereof of processing said Chinese medicine are:
Rhizoma Cyperi 134-154 part Folium Perillae 86-106 part Radix Glycyrrhizae Preparata 86-106 part
Fructus Citri 134-154 part Cortex Magnoliae Officinalis 134-154 part Fructus Amomi Rotundus (stir-fry) 150-170 part
Fructus Amomi (stir-fry) 150-170 part Rhizoma Polygonati 134-154g Radix Astragali Preparata 182-202 part.
Raw material composition and the weight proportion thereof of processing above-mentioned Chinese medicine are:
96 parts of 96 parts of Radix Glycyrrhizae Preparatas of 144 parts of Folium Perillaes of Rhizoma Cyperi
160 parts of Fructus Citri 144 portions of Fructus Amomi Rotunduss of 144 parts of Cortex Magnoliae Officinalis (stir-fry)
192 parts of 144 parts of Radix Astragali Preparatas of 160 parts of Rhizoma Polygonatis of Fructus Amomi (stir-fry).
A kind of method for preparing that is used to treat the Chinese medicine preparation of gastritis, gastric ulcer is characterized in that, comprises the steps:
(1) get Rhizoma Cyperi, Folium Perillae, Fructus Citri, Cortex Magnoliae Officinalis, Fructus Amomi Rotundus (stir-fry) and Fructus Amomi (stir-fry) nine flavor crude drug mixed powders and be broken into fine powder, subsequent use;
(2) again Radix Glycyrrhizae Preparata, Radix Astragali Preparata, Rhizoma Polygonati three flavor crude drug are mixed, decocte with water twice, 10 times of amounts decocted 2 hours for the first time, added 8 times of water gagings for the second time and decocted 1.5 hours, merged medicinal liquid twice, concentrated and oven dry, pulverized, and crossed 100 mesh sieves;
(3) with twice gained fine powder mixing, pill, dry below 60 ℃, polishing promptly gets.
The present invention has following advantage and effect with respect to prior art:
1, reasonable recipe, compatibility is simple; Cautiously grasping pathogenesis of the present invention, medication is terse, and compatibility is exquisite.
2, cheap, be easy to the patient and accept; Adopt 9 flavor Chinese medicines to be equal common medicines, be easy to compatible combination, suitable for large-scale promotion.
3, therapeutic effect is remarkable, does not see obvious toxic and side effects, and the treatment effective percentage reaches 100%, and cure rate reaches more than 98%.
The specific embodiment
Do not have the name of diseases such as " chronic atrophic gastritis ", " gastric ulcer " in motherland's medical science; But lapse to etc. according to its clinical manifestation, etiology and pathogenesis, prognosis, can it be belonged to disease categories such as " feeling of fullness ", " stomachache ", " stomach painful abdominal mass ", " acid regurgitation ", " noisy " and discuss and control.The disease of " feeling of fullness ", head is shown in " interior warp ", is not referred to as not, painful abdominal mass, full, feeling of fullness, painful abdominal mass plug, call like " element asks lunar sun bright opinion ": " eating and drinking without temperance, daily life is the person frequently, the moon receives it ... go into the five internal organs then the moon very full obturation "; " element ask treatment in accordance with local conditions opinion " said: " coldness of ZANG-organ is given birth to full pain ", think the generation and the improper diet of feeling of fullness, zang-fu organs qi movement is unfavorable relevant.The basic conception of " Treatise on Febrile Diseases is distinguished sun abnormal pulse card and controls " clear and definite painful abdominal mass: " but feeling fullness but no pain person this be painful abdominal mass "; Point out that mostly its pathogenesis is the diseases caused by exogenous pathogenic factor using purgation by mistake to treat exterior syndrome; Vital QI being weakened and pathogen being violent is tied under the heart, and drafts the principle of treatment of simultaneously using both cold and hot drugs, pungent drugs can disperse and bitter drugs can descend; Its XIEXIN TANG of creating treatment feeling of fullness, followed for back physicians from a family for generations family always; Li Dongyuan proposes in " secret record of the orchid chamber fullness in the epigastrium and abdomen abdominal distention ": " spleen is wet has a surplus the abdominal distention dyspepsia ", think main dirty at spleen, contained zhishi xiaopi pills is the name side of treatment feeling of fullness; " Jing Yue's complete work feeling of fullness " proposed the argument that feeling of fullness is controlled the branch deficiency and excess, says: " allly have heresy to have to stagnate and painful abdominal mass person, stuffiness syndrome of excess type also; Naivete does not have stagnant and painful abdominal mass person, and stuffy sensation of deftciency type also.The stuffiness syndrome of excess type person can loose and can disappear, and the stuffy sensation of deftciency type person must big temperature compensation ".And more in classic doctor's nationality to the argumentation of stomachache, as pointing out in " interior warp ", cause the reason of gastric abscess to catch cold, depression of liver-QI and interior-heat etc., " element is asked and lifted the pain opinion " said: " the cold visitor is between the intestines and stomach, under the pleurodiaphragmatic in terspace, and blood must not loose, contraction of small collaterals resulting in pain." " element is asked the hexa-atomic big opinion of just recording " say: " strongly fragrant the sending out of wood, the sick epigastralgia right below the heart of the people."; " Renzhai Zhi Zhi Fang, Effective Recipes from Renzhai House " has realized that to the reason of stomachache " have coldly, heat is arranged, dead blood is arranged, food stagnation is arranged, phlegm retention is arranged, worm is arranged " wait difference; " danxi's experiential therapy heart splenalgia " once pointed out " all pains can not QI invigorating ", very big to influence later age when discussing the stomachache method of treatment, and seal is clinical, and this lifting manipulation is still owed comprehensively, and medical science was corrected and replenished it gradually later age.And gastric ulcer belongs to the traditional Chinese medical science " gastric abscess " category, and " Jing Yue's complete work cardiac and abdominal pain " is very detailed for the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs analysis of gastric abscess, points out: " pain has a deficiency and excess ... distinguish method, but can be by the person for empty when examining it, the tenderness person be in fact; How empty pain person is for a long time, and how real sudden and violent patient is; The person is for empty slightly but must eat, and distension fear trencherman is real; Pain is delayed slowly, and how empty the person of Mo Deqi place is, and the pain play is then hard, and it is real not moving the person scarcely; How real pain have thing to have stagnant person in intestines and internal organs of the body, and pain is side of body meridians in the chamber, not dried apoplexy involving ZANG-organ and involve the back, and not having expands does not have how void of the person of stagnating.Arteries and veins and card ginseng, deficiency and excess is from distinguishing "; " card control converge mend gastric abscess " proposes to the treatment of stomachache that " big rate gas food is in the majority, can not use tonic suddenly, the flow of QI being obstructed of top capping and bitterly more.If the article of clothes attacks once, more back recurrence is sent out repeatly repeatly and is attacked, and gradually float big and empty person to arteries and veins, mends when training again " worth reference.
Chinese medical theory thinks, the disease position of this type of disease is mainly at gastral cavilty, and closely related with liver, spleen, at the pathogenesis conversion aspect, has by gas and blood, and Sthenia is transforming into asthenia, transformation between cold and heat, or injury of YANG due to overabundant cold, characteristics such as heat-transformation impairment of YIN; It is pathogenic because of, all ends such as not outer exterior evil inward invasion, indigestion, disorder of emotion, weakness of the spleen and stomach to study carefully it.Its pathogenesis crux is the spleen and stomach function obstacle, burnt mechanism of qi retardance in causing, abnormal ascending-descending of QI; Exopathogen invasion and attack flesh table, treatment is done not know the right way, and the misuse dispelling pathogen in the interior rushes down down, and taste are impaired, in exopathogen sinks in an opponent's defence, tie under the heart, hinder in middle burnt mechanism of qi.If plain body weakness of spleen and stomach, deficiency of QI in middle-JIAO, or because of affection of exogenous wind-cold, or the liver failing to maintain the normal flow of QI; Or because of the diseases caused by exogenous pathogenic factor pathogenic heat, or have a liking for partially because of eating and drinking without temperance, burnt in the retardance, or long-term muscle power or mental work excessively, irregular diet; Impairing the spleen and stomach, or gastric qi is not multiple after being ill, QI and blood loses smooth, and the stomach film is not given birth to; Violated by cold and heat again, cause dysfunction of the spleen in transportation, disorder of QI movement, stomach-QI being unable to descend normally.Therefore, clinical treatment, how with dispersing the stagnated liver-QI for regulating the stomach, the warming middle-JIAO painful abdominal mass that disappears, heat clearing awayization stagnates, regulating QI to relieve pain, method of treatment such as invigorating spleen and reinforcing stomach, blood circulation promoting and blood stasis dispelling, regulating cold and heat are main.
The present invention is based on Chinese medical theory and modern medicine study; In conjunction with long-term clinical treatment practical experience; Forms by the nine flavor drug matchings of Rhizoma Cyperi, Folium Perillae, Radix Glycyrrhizae Preparata, Fructus Citri, Cortex Magnoliae Officinalis, Fructus Amomi Rotundus, Fructus Amomi, Rhizoma Polygonati, Radix Astragali Preparata, and with Rhizoma Cyperi, Folium Perillae two flavors be directed against that function is regulated the flow of vital energy, stomach function regulating, pain relieving pathogenesis be made as monarch drug; With Fructus Amomi Rotundus, Fructus Citri, Cortex Magnoliae Officinalis principal drug assistance capablely stagnate to strengthen its regulating qi-flowing for strengthening spleen, the merit of the chest stuffiness relieving and stomach and alleviating pain and be made as ministerial drug; Help monarch-minister drug to strengthen the merit of its regulating qi-flowing for harmonizing stomach with Fructus Amomi, Rhizoma Polygonati, Radix Astragali Preparata three flavor assistants, can help again and help monarch-minister drug to be made as adjuvant drug with the power that strengthens its QI invigorating nourishing the stomach, spleen benefiting and stimulating the appetite; But with Radix Glycyrrhizae QI invigorating invigorating middle warmer relieving spasm to stop pain is adjuvant drug, simultaneously again can coordinating the actions of various ingredients in a prescription, can be messenger drug again; Nine flavor Chinese medicine combineds effect, the circulation of qi promoting of regulating the flow of vital energy is shared, the spleen reinforcing stomach reinforcing is with executing, QI invigorating and do not stagnate greasy, circulation of qi promoting and dispelling the stagnated QI not, medication is terse, compatibility is exquisite.
Number flavor herbal nature carries out as detailed below in the prescription of the present invention:
1, Rhizoma Cyperi, acrid in the mouth, sweet, little hardship, property is flat, returns liver, tri-jiao channel; The resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving, antiabortive function cures mainly incoordination between the liver and stomach, depression of QI, breast abdomen feeling of fullness, distending pain over the hypochondrium, menoxenia, abdominal pain during menstruation, bleeding not during menses, frequent fetal movement; " the southern regions of the Yunnan Province book on Chinese herbal medicine " put down in writing its " transfer the gas in the blood, dissipating depression of QI gas and transfer all gas, alleviating distention in middle-JIAO helps digestion, preventing or arresting vomiting is told and middle nourishing the stomach, feed."; " detailed outline " sayed its " the cold epidemic disease of the seasonal epidemic pathogens that looses, sharp three warmers are separated six kinds of stagnation-syndromes, the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention ".
2, Folium Perillae, sweet in the mouth, warm in nature, return lung, spleen, stomach warp; But circulation of qi promoting with in, fullness in the epigastrium and chest, nausea and vomiting, stomachache is vomited and diarrhoea; " solar corona " said: " invigorating the spleen and replenishing QI.Control trusted subordinate's distension " " whetting the appetite, and (controlling) all cold air ".
3, Fructus Citri, sweet in the mouth, hardship, acid, warm in nature, return liver, lung, spleen channel; The ability regulating QI and lowering the adverseness, the chest stuffiness relieving reduces phlegm, and it is vexed to cure mainly the breast abdominal distention; " property of medicine is wanted in the medical center bun ": " control gastric abscess, alleviating distention in middle-JIAO is pleasant, dissipating depression of QI "; " explaining abstruseness of the canon of materia medica ": " gas of the reason part of the body cavity above the diaphragm housing the heart and lungs, preventing or arresting vomiting is contrary, feed, spleen invigorating ".
4, Cortex Magnoliae Officinalis, bitter in the mouth, suffering, warm in nature, return spleen, stomach, large intestine channel; The circulation of qi promoting removing food stagnancy, dampness is removed full, and lowering the adverse QI to relieve asthma cures mainly stagnation of QI due to dyspepsia, and the gastral cavity painful abdominal mass is vomited and diarrhoea, and expectorant is stopped up the QI rising in reverse order, and fullness in the chest is breathed with cough; " the golden Qiu Bencao that comes together states record ": " warming middle-JIAO eliminating stagnation gas removes distension, in the humidity hysteresis stomach, and cold contrary vomiting, stomachache is let out profit, cold warm cholera, digesting and absorbing the essence of foodstuff ".
5, Fructus Amomi Rotundus, acrid in the mouth, warm in nature, return lung, spleen, stomach warp; Warming middle-JIAO to arrest vomiting, powder for improving appetite food cures mainly incoordination between the spleen and stomach, distension and fullness in the abdomen, anorexia, hygropyrexia from the beginning of, uncomfortable in chest not hungry, gastrofrigid vomiting, food stagnation does not disappear; Be used for wet resistance taste, the stagnation of QI in spleen and stomach card; " Kaibao Bencao ": " main accumulation of pathogenic cold gas, preventing or arresting vomiting is contrary, regurgitation, the rapid digestion of food therapeutic method to keep the adverse QI flowing downwards ".
6, Fructus Amomi, acrid in the mouth, warm in nature, return spleen, stomach, kidney channel; But promoting the circulation of QI to alleviate the stagnation in middle-JIAO is warming spleen and stopping diarrha, kind removing dampness, and warming middle-JIAO is the good merchantable brand of the appetizing of being amusing; Cure mainly retention of damp leading to blockage of QI, distension and fullness in the abdomen, anorexia, nausea and vomiting, stomachache is had loose bowels; " detailed outline ": " tonifying the lung is amusing, the nourishing the stomach kidney tonifying, and reason vigour, dispelling stagnant Qi, the cold expelling drink expands tired ".
7, Rhizoma Polygonati, sweet in the mouth, property is flat, returns spleen, lung, kidney channel; Invigorating the spleen and replenishing QI, control insufficiency of the spleen weak, the lack of appetite xerostomia; " Taoist Scriptures angle ZHICAO warp ": " alleviating distention in middle-JIAO QI invigorating, the five internal organs are transferred good ";
8, the Radix Astragali, sweet in the mouth, warm in nature.Return lung, spleen channel; Be used for deficiency of both the splenic and pulmonary QI, the card of sinking of QI of middle-JIAO has the merit of invigorating middle warmer, QI invigorating, yang invigorating, cures mainly diarrhea due to hypofunction of the spleen; " medicine origin " is said: " the kind weakness of the spleen and stomach of controlling ".
9, Radix Glycyrrhizae, sweet in the mouth, property is flat, returns spleen, stomach, the heart, lung meridian; The QI invigorating invigorating middle warmer is arranged, relieving spasm to stop pain, the function of coordinating the actions of various ingredients in a prescription; " property of medicine collection will " be sayed its " slow healthy energy, regulating liver-QI, pain relieving, granulation promoting meat, yin nourishing blood ".
And show through modern medicine study in the above-mentioned Chinese medicine, wherein:
1, Rhizoma Cyperi
(1) to the effect of intestinal and tracheal smooth muscle
During Rhizoma Cyperi ethanol extract 20ug/kg concentration, the isolated rabbit ileum smooth muscle there is direct repression, and can be, guinea pig bronchial spasm due to the histamine spraying is had protective effect the contraction of anti-acetylcholine, barium chloride and 5-hydroxy tryptamine to myenteron.
(2) antiinflammatory action
Cyperol extract 100mg/kg lumbar injection has the obvious suppression effect to chondrus ocellatus Holmes alkali and formaldehyde-caused rat swelling of the feet, and the effective ingredient of antiinflammatory action is a triterpenoid compound.
2, Folium Perillae
(1) to the gastrointestinal effect
The secretion of Folium Perillae ability facilitating digestion liquid, the enhance gastrointestinal wriggling.Perilla ketone can promote the mouse small intestine wriggling, and its ED50 that irritates stomach is 11mg/kg, is 1/7 of LD50, and the effectiveness that perilla ketone 15mg/kg promotes carbon powder to discharge is better than Oleum Ricini 60mg/kg or magnesium sulfate 100mg/kg.
(2) to Immune Effects
The ether extract of Folium Perillae can strengthen lymphocyte immunologic function, and on the contrary, ethanol extraction and perillaldehyde have immunosuppressive action; The hot water extract 25mg/ml of Folium Perillae has obvious inhibitory action to the inductive rat hypertrophy cell histamine release of compound 48/80.
3, Radix Glycyrrhizae Preparata
(1) antiulcer action
Radix Glycyrrhizae extractum is to rat ligation pylorus, and the ulcer that dog is brought out by histamine has the obvious suppression effect.The extract of liquiritigenin, isoliquiritin unit and licorice etc. has the obvious suppression effect to the zoopery ulcer.Enoxolone has good antiulcer action to the rat of pylorus ligation.
(2) to the influence of gastric acid secretion
Radix Glycyrrhizae fluidextract can directly absorb gastric acid, can reduce the gastric acid of normal dogs and experimental ulcer rat.Intraduodenal administration can suppress the gastric secretion on basis to the rat of acute and chronic gastric fistula and pylorus ligation, has share synergism with paeoniflorin; FM100 has significant inhibitory effect to the gastric secretion that peptone, histamine and Methanamide choline cause.
(3) to the effect of gastrointestinal smooth muscle
Decoct, fluid extract, FM100, glycyrrhizin, isoliquiritigenin etc. have inhibitory action to intestine in vitro.When if intestinal tube is in spasticity, then have obviously and spasmolysis.
4, Fructus Citri
(1) antiinflammatory action
Hesperidin to Cavia porcellus for want of vitamin C and cohesion of the eyes bulbar conjunctiva blood vessel inner cell that causes and capillary resistance reduce the improvement effect arranged, can reduce the cohesion of horse blood cell.With the thromboembolism feedstuff or with feed rat jointly to atherosis feedstuff, but equal prolong rats time-to-live.Can stimulate the speed of growth of the Cavia porcellus of the C that is deficient in vitamin, increase ascorbic content in Cavia porcellus adrenal gland, spleen and the leukocyte.
(2) antivirus action
Hesperidin adds in the vesicle property stomatitis virus, the mice fibrocyte is put in the hatching of carrying out ahead of schedule in the hesperidin of 200ug/ml and handles, and can protect cell not receive the about 24h of virus infraction.Anticipating the Hela cell can the viral infection of flu-prevention.
(3) obacunone that contains has the effect that strengthens isolated rabbit intestinal tension force and amplitude.
5, Cortex Magnoliae Officinalis
(1) Cortex Magnoliae Officinalis extract has the Mus HCl-of Chinese People's Anti-Japanese Military and Political College ethanol ulcer function.Rat body weight 200g administration group PO Cortex Magnoliae Officinalis 50% ethanol extraction is established matched group simultaneously, behind the administration 1h, gives HCl-ethanol 15%, puts to death animal behind the 1h, and ulcer length (mm) aggregate value that takes place with membranous part is as UI, and matched group relatively.Administration group as a result is remarkable inhibitory action to gastric mucosa ulcer, and one of its active component is confirmed as honokiol and magnolol;
(2) utilize the water logging stimulus method to cause the irritability acute gastric ulcer of rat; Measure the rat gastric secretion with the gastric perfusion method; Be determined at the gastrorrhagia of the rat of stress loading under the simulated gastric fluid perfusion condition, the result shows that magnolol has the handicapped effect of the irritability of preventing stomach;
(3) give birth to article Cortex Magnoliae Officinalis decoct through rat ig10%, 10% Cortex Magnoliae Officinalis (processed with ginger) decoct is to pyloric ligation ulcers and stress inhibitory action all be arranged type ulcer, and effective dose is 10g/kg.The antiulcer action of Cortex Magnoliae Officinalis (processed with ginger) is strong.
6, Fructus Amomi (parched) is to the influence of digestive system intestine in vitro smooth muscle
Get rat, Cavia porcellus or rabbit intestinal and put in the tyrode bath for one section,, observe medicinal liquid the influence of intestinal tube spontaneous activity and the effect of antagonism acetylcholine and BaCl2 through monitor record intestinal tube activity change.The Fructus Amomi decoct can make Cavia porcellus, mouse small intestine intestinal tube shrink reinforcement as a result, during escalated dose intestinal tube is had inhibitory action, and performance tension force reduces, and amplitude reduces.
7, Rhizoma Polygonati is to Immune Effects
Rhizoma Polygonati can improve body's immunological function and promote DNA and RNA and proteinic synthetic.Its polysaccharide extract has the LT effect of promotion; After also observing the lethal dose with 60CO irradiation 90%, give the polygonatum polysaccharide mice in spleen weightening finish in 9-11 days significantly, hemopoietic focus also increases, and the dna content of internal organs such as mice spleen, liver, the heart increases.
8, Radix Astragali Preparata
(1) effect of enhancing human body immunity function
The Radix Astragali strengthens the activate the phagocytic capacity of mononuclear phagocyte in humoral immunization, and to somatic cell, natural killer cell discharges immunologic active material, inducement interferon, and many-sides such as interleukin show multiple physiologically active.Astragalus decoction po can increase the phagocytic function of mice chrotoplast, and the infection of mice I type influenza virus is had protective effect, and one of its antiviral principle possibly be to improve the function of patient's leukocyte inducement interferon.The normal person takes lgM behind the Radix Astragali herb extractum sheet, and lgE significantly increases.The Radix Astragali can promote cytophagous phagocytic function, can promote the propagation of B cell and suppress total complement active, and the generation of interleukin is induced effect, promotes mouse lymphocyte that the immunologic opsonin rosette of Sanguis caprae seu ovis ball is formed.Under the immunologic function that immunosuppressant is caused obvious facilitation being arranged, is to have the beidirectional immunomodulator; Astragalus polysaccharides is one type of stronger material of immunocompetence in the Radix Astragali.It can strengthen cytophagous phagocytic function; From spleen and thymic weight, hemolysin, hemagglutinin and splenocyte sum and plaque forming cells measure and find out, and astragalus polysaccharides, Hedysamn polysaccharide all can have the immunosuppressive action of cyclophosphamide or meticortelone and reach the part antagonism fully; Astragalus polysaccharides descends to complement after handling through cobra venom factor, and the Cavia porcellus that phagocytic rate descends has the complement of promotion to recover, and promotes the function that the neutrophilic leukocyte phagocytic rate improves and recovers.
(2) Radix Astragali can strengthen the reactivity of PBLC to 1L-2, and TH is had tangible stimulation.Astragalus polysaccharides in vivo, in-vitro application can obviously improve burned mice T lymphocyte transformation, the expression of 1L-2 and 1L-2K.
The present invention is according to Chinese medical theory and modern medicine study achievement, in conjunction with long-term gynecological clinic medical practice experience, and with reference to the modern pharmacological research result, the medicine pill that develops, following embodiment:
Embodiment 1
A kind of Chinese medicine preparation that is used to treat gastritis, gastric ulcer is at first got Rhizoma Cyperi 144 g, Folium Perillae 96 g, Fructus Citri 144 g, Cortex Magnoliae Officinalis 144 g, Fructus Amomi Rotundus (stir-fry) 160 g and Fructus Amomi (stir-fry) 160 g nine flavor crude drug mixed powders and is broken into fine powder, and is subsequent use; Again Radix Glycyrrhizae Preparata 96 g, Radix Astragali Preparata 192 g, Rhizoma Polygonati 144 g three flavor crude drug are mixed, decocte with water twice, 10 times of amounts decocted 2 hours for the first time, added 8 times of water gagings for the second time and decocted 1.5 hours, merged medicinal liquid twice, concentrated and oven dry, pulverized, and crossed 100 mesh sieves; At last with twice gained fine powder mixing, conventional pill, dry below 60 ℃, polishing promptly gets.
Embodiment 2
A kind of medicine pill that is used to treat gastritis, gastric ulcer is at first got Rhizoma Cyperi 134 g, Folium Perillae 106 g, Fructus Citri 154 g, Cortex Magnoliae Officinalis 134 g, Fructus Amomi Rotundus (stir-fry) 170 g and Fructus Amomi (stir-fry) 150 g nine flavor crude drug mixed powders and is broken into fine powder, and is subsequent use; Again Radix Glycyrrhizae Preparata 86 g, Radix Astragali Preparata 182 g, Rhizoma Polygonati 154 g three flavor crude drug are mixed, decocte with water twice, 10 times of amounts decocted 2 hours for the first time, added 8 times of water gagings for the second time and decocted 1.5 hours, merged medicinal liquid twice, concentrated and oven dry, pulverized, and crossed 100 mesh sieves; At last with twice gained fine powder mixing, conventional pill, dry below 60 ℃, polishing promptly gets.
Embodiment 3
Smart medicine pill is supported in a kind of the kidney invigorating, at first gets Rhizoma Cyperi 154 g, Folium Perillae 106 g, Fructus Citri 154 g, Cortex Magnoliae Officinalis 154 g, Fructus Amomi Rotundus (stir-fry) 150 g and Fructus Amomi (stir-fry) 150 g nine flavor crude drug mixed powders and is broken into fine powder, and is subsequent use; Again Radix Glycyrrhizae Preparata 106 g, Radix Astragali Preparata 202 g, Rhizoma Polygonati 134 g three flavor crude drug are mixed, decocte with water twice, 10 times of amounts decocted 2 hours for the first time, added 8 times of water gagings for the second time and decocted 1.5 hours, merged medicinal liquid twice, concentrated and oven dry, pulverized, and crossed 100 mesh sieves; At last with twice gained fine powder mixing, conventional pill, dry below 60 ℃, polishing promptly gets.
In the foregoing description, embodiment 1 effect is best.
Embodiment 4
Acute toxicity test in mice
Test objective: administration is 2 times in 24 hours; Observe mice and accept the acute poisoning reaction that excessive stomach health ball is produced, for the toxicity test design dosage of repetitively administered repeatedly, analyze toxic action target organ, analyze that clinical dosage of toxic reaction, I phase that human body possibly occur when excessive is selected and the design of observation index provides reference information etc.
1, experimental condition
1.1 animal strain: ICR mice body weight 18-22g, ♀ ♂ half and half is provided credit number: 0034660 by The Fourth Military Medical University's Experimental Animal Center.Raised 3 days before the experiment, select behavioral activity, diet, the normal mice of mental status to experimentize.
1.2 feeding and management: room temperature 20-24 ℃, relative humidity 40%-70%, illumination 8 hours/day, exhaust fan ventilates 2 times/day, and each 1 hour, ♀ ♂ sub-cage rearing, water (tap water) freely absorbs, and feedstuff is the laboratory animal full nutrition feed.
1.3 receive the reagent thing:
1.3.1 title: stomach health ball (medicine pill of the present invention)
1.3.2 lot number: 090801
1.3.3 source: Shenmu County's Chinese medicine institute
1.3.4 usage and dosage: oral, every day 3 times, each 30 balls, 30 balls contain patent medicine 3.44g, day clothes crude drug amount 10.33g, the suitable 1.28g crude drug of 1g; Body weight is by 60 kg, and per kilogram of body weight is obeyed crude drug amount 0.17g.Because of the pill slag is many, compound concentration is low, and dosage is also low, add 80ml water (60 ℃ of water temperatures) and soak 30min so the 20g pill time is got in test, and 2 times repeatedly, filter the back merging filtrate, be concentrated into 40ml, be made into 50.0% concentration (can irritate the Cmax of stomach).
2, test method
2.1 prerun:
Get 2 of ICR mices, each 1 of male and female, body weight 18-22g, fasting is 12 hours before the administration, and dosage is respectively 50.0% concentration 0.4ml/10g, and perfusion is 2 times in 24 hours, observes the mice ordinary circumstance after the administration.See the mice activity freely, it is normal to take food, drink water, and mice did not have 1 death in 72 hours, did not have obvious toxic reaction yet, pointed out these article to be difficult to measure LD50, tests so select to receive greatly most reagent thing amount.
2.2 receive the test of reagent thing amount most greatly:
Get 40 of mices, ♀ ♂ half and half, body weight 18-22g; Fasting is 12 hours before the administration, with 2 perfusions in the stomach health ball of 50.0% concentration 24 hours, administration 0.4ml/10g; Observe two weeks, itemized record mice behavioral activity, state, diet, defecation and hair color, secretions etc. continuously.
3, result of the test
40 mice outward appearance sign no abnormality seens, activity freely, the feed, drinking-water all normal, fur is bright and clean; Mouthful, nose and the no abnormal secretions of eye, observed for two weeks continuously, body weight has increase, body weight before the administration, the 7th day, the 14th daily weight are seen table 1; 20 mices of administration group all survive, and do not have obvious toxic reaction, dissect finding: thoracic cavity, abdominal cavity no abnormality seen liquid; Intestinal tube is not seen flatulence, and important organs such as the heart, liver, spleen, lung, kidney are not seen color, paramophia, do not have petechia or other pathological change; The gastric mucosa color is ruddy, no petechia or ulcer, and postmortem is no abnormal.
Four, conclusion (of pressure testing)
Stomach health ball (the administration capacity of concentration by 50.0% and 0.4ml/10g) does not measure LD50 for ICR strain mouse stomach; Administration is 2 times in 24 hours, observes 14 days, and mice does not have death; It receives reagent thing amount most greatly is 51.2g/kg (crude drug), is about clinical people and intends 297.4 times of consumption.Under this dosage, do not observe the toxic reaction of stomach health ball.
The present invention and so on case is listed below:
Case 1:
Bai, man, 47 years old, the cook of chicken Town Government in Shenmu County.On June 16th, 1986 came to go to a doctor.Carry on May 10th, 1986 in the Inner Mongol Dong Shengmeng hospital gastroscope report: multiple gastric ulcer.There is the ulcer of 1.2cm*1.0cm*0.5cm size in stomach angle central authorities, edema, and gastric mucosa is coarse, and lamellar is congested, and depression is arranged.
Private prosecution in person: played frequent gastric acid stomachache, acid regurgitation in 18 years old, successively in county hospital and the apart treatment of township hospital, curative effect is general, increases the weight of in nearly 3 years, and big loose stool is thin.
Have a medical check-up: deep pulse, tongue is light, dark tongue quality.
Take pill 120 balls of the present invention (containing patent medicine 13.76g altogether), each 1 ball, every day 2 times, go middle chicken in August, 2002, sees that white cook's health is sturdy, energetic, gastric ulcer not recurrence again in 16 years.
Case 2:
Strongly fragrant certain, man, 48 years old, the abundant village self-employed entrepreneurs of Kelan County, Shanxi Province west leopard.On November 27th, 1998 came to go to a doctor.In June, 1996 Taiyuan, Shanxi city hospital and in August, 1998 packet header two hospitals do gastroscope report respectively for twice: chronic atrophic gastritis.
My private prosecution: suffered from gastropathy more than 10 year, and, went to a place, buy the Western medicine that some control gastropathy, but curative effect is general because of being the small item self-employed entrepreneurss, still outbreak so far, light bitterly the time during stomach.
Have a medical check-up: body is thin, and slow pulse is slow, and tongue is light, and body of the tongue has petechia, big loose stool, and urine is normal, poor appetite, pipe abdomen fullness, extremity are not warm, the tired power of waist, cardiopulmonary are normal, do not have other diseases again.
Press the spleen renal deficiency type, give herbtherapy, obey pill 90 balls of the present invention again, each 1 ball, every day 2 times with kidney and spleen invigorating holder skin ulcer granulation promoting method.
Before JIUYUE 13 in 2003 Japaneses: " my gastropathy is cured, and nearly 6 years fine always, weight increase more than ten jin ".
Case 3:
Zhang, man, 43 years old, the workman of Shenmu County machinery plant.On JIUYUE 19th, 1989 came to go to a doctor.
My private prosecution: had a stomach-ache since 36 years old, successively in Xi'an, some examination in hospital in other places, be diagnosed as atrophic gastritis, the treatment back state of an illness is heavy when light still the time.Poor appetite, the loose stool, in time, be hard and dry, and is yellow during urine, bitter taste, xerostomia, but hydroadipsia, body is thin weak, the flatulence abdominal distention, several years ago warm improvement, present changes in temperature are the same.
Have a medical check-up: cardiopulmonary are normal, and body temperature is normal, and gastral cavilty portion pain is obvious, and extremity are not warm, but the extremity pneumonedema, waist is stranded, deep-thready pulse, and tongue is light, and matter is dark.Hope color: lassitude, physical weakness.
Take pill 120 balls of the present invention (containing patent medicine 13.76g altogether), each 1 ball, every day 2 times, through repeatedly investigation, not recurrence again in 12 years, weight increase, spirit is fair.
Case 4:
Temperature certain, the man, 46 years old, Inner Mongolia Autonomous Region cadre of General Office of Finance of district government come to go to a doctor on May 21st, 1988, existing 8 years of gastropathy does not obtain radical cure through western medicines in treatment.301 hospital general's gastroscopes are made a definite diagnosis in Beijing: 1 esophagitis; 2 superficial gastritiss; 3 duodenal ulcers.
Have a medical check-up: cardiopulmonary are normal, do not have other diseases, stringy and rolling pulse, and the little Huang of tongue has diarrhea before dawn, and is weak, and waist is stranded.
Take pill 120 balls of the present invention (containing patent medicine 13.76g altogether), each 1 ball, every day 2 times.Investigation on July 16 calendar year 2001 is from the not recurrence in back 5 years of taking medicine.
Case 5:
Scape, man, 51 years old, Shenmu County's cleaned coal company coal miner.Came to go to a doctor in 16th in December in 1996.
Private prosecution in person: year surplus the trouble gastral cavilty portion pain 10.Have a stomach-ache the bimester of near and increase the weight of, once use multiple western medicine heterodyne, gastroscope turns out to be: antral gastritis.
Have a medical check-up: pain on the right side, seemingly there is thing top sensation in gastral cavilty portion, is hard and dry red tongue, thready and stringy pulse.There are not other diseases again.
Take pill 90 balls of the present invention (containing patent medicine 10.32g altogether), each 1 ball, every day 2 times." Invest, Then Investigate ", in January, 1997 is not recurrence so far, and health is fine.
Above-mentioned clinical data shows that the effect of medicine pill of the present invention is conspicuous:
1. the treatment effective percentage reaches 100%, and cure rate reaches more than 98%.
2. follow up a case by regular visits to after more and show, do not recur after more.
3. the patient is followed up a case by regular visits to and show that this Chinese medicine preparation has no side effect, no Drug resistance and drug resistance.
Claims (3)
1. Chinese medicine preparation that is used to treat gastritis, gastric ulcer is characterized in that: the raw material of processing said Chinese medicine forms and weight proportion is:
Rhizoma Cyperi 134-154 part Folium Perillae 86-106 part Radix Glycyrrhizae Preparata 86-106 part
Fructus Citri 134-154 part Cortex Magnoliae Officinalis 134-154 part parch Fructus Amomi Rotundus 150-170 part
Parch Fructus Amomi 150-170 part Rhizoma Polygonati 134-154g Radix Astragali Preparata 182-202 part.
2. Chinese medicine preparation that is used to treat gastritis, gastric ulcer as claimed in claim 1 is characterized in that: the raw material of processing said Chinese medicine forms and weight proportion is:
96 parts of 96 parts of Radix Glycyrrhizae Preparatas of 144 parts of Folium Perillaes of Rhizoma Cyperi
160 parts of 144 parts of parch Fructus Amomi Rotunduss of 144 parts of Cortex Magnoliae Officinalis of Fructus Citri
192 parts of 144 parts of Radix Astragali Preparatas of 160 parts of Rhizoma Polygonatis of parch Fructus Amomi.
3. claim 1 or 2 described Chinese medicine preparation is characterized in that, comprise the steps:
(1) get Rhizoma Cyperi, Folium Perillae, Fructus Citri, Cortex Magnoliae Officinalis, parch Fructus Amomi Rotundus and parch Fructus Amomi Six-element crude drug mixed powder and be broken into fine powder, subsequent use;
(2) again Radix Glycyrrhizae Preparata, Radix Astragali Preparata, Rhizoma Polygonati three flavor crude drug are mixed, decocte with water twice, 10 times of amounts decocted 2 hours for the first time, added 8 times of water gagings for the second time and decocted 1.5 hours, merged medicinal liquid twice, concentrated and oven dry, pulverized, and crossed 100 mesh sieves;
(3) with twice gained fine powder mixing, pill, dry below 60 ℃, polishing promptly gets.
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1362257A (en) * | 2001-12-26 | 2002-08-07 | 邹明义 | Gastrosis treating Chinese medicine prepn. |
CN101181583A (en) * | 2007-11-21 | 2008-05-21 | 张敏刚 | Chinese medicine composition orally taken for curing chronic gastritis |
CN101757537A (en) * | 2009-08-10 | 2010-06-30 | 黄山 | Stomach harmonizing and spleen strengthening granule |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN1362257A (en) * | 2001-12-26 | 2002-08-07 | 邹明义 | Gastrosis treating Chinese medicine prepn. |
CN101181583A (en) * | 2007-11-21 | 2008-05-21 | 张敏刚 | Chinese medicine composition orally taken for curing chronic gastritis |
CN101757537A (en) * | 2009-08-10 | 2010-06-30 | 黄山 | Stomach harmonizing and spleen strengthening granule |
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