CN105168741A - Preparation method of memory-improving tablets - Google Patents
Preparation method of memory-improving tablets Download PDFInfo
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- CN105168741A CN105168741A CN201510487735.6A CN201510487735A CN105168741A CN 105168741 A CN105168741 A CN 105168741A CN 201510487735 A CN201510487735 A CN 201510487735A CN 105168741 A CN105168741 A CN 105168741A
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Abstract
The invention discloses a preparation method of memory-improving tablets. The method includes the steps of 1, preparing Epimedium dry extract A; 2, weighing yam rhizome powder, and sieving it with a 60-mesh sieve for standby; 3, preparing Morinda officinalis and Chinese wolfberry extract; 4, mixing the rhizome powder with the Morinda officinalis and Chinese wolfberry extract obtained in the step 3, and performing vacuum drying to obtain mixed dry extract B; 5, mixing the Epimedium dry extract A obtained in the step 1 and the Morinda officinalis and Chinese wolfberry extract B obtained in the step 4, crushing a mixture with a crusher to obtain powder, sieving the power with a 100-mesh sieve, adding microcrystalline cellulose, performing uniform mixing, wetting a mixture with 90% ethyl alcohol to obtain soft material, granulating the soft material, drying granules at 70 DEG C to obtain dried granules, adding a lubricant into the granules, and performing mixing and tableting to obtain the tablets. The tablets prepared by the preparation method have good effect in terms of appearance, disintegration, hardness and tablet weight difference.
Description
Technical field
The present invention relates to a kind of preparation technology field of tablet, specifically refer to a kind of preparation method with Improving memory function tablet.
Background technology
Along with the aggravation of socioeconomic development and aged tendency of population trend, current medical model there occurs change gradually, and people develop into the present active state not having disease diseases prevention from ill passive state of curing the desease; In addition, the Diet concept also forward health product conversion of people, increasing substantially of medical expense, makes people more healthy, and the idea of Chinese medicine preventing diseases instead for the treatment of diseases receives the attention of more and more people.Therefore, to develop with the Chinese medicine of integration of edible and medicinal herbs be raw material, and health food has wide application space.
According to the raw marrow of Chinese medicine kidney, the brain being the reservoir of the marrow, kidney hides intelligence, kidney is not raw then can not expire, and the kidney being the origin of congenital constitution, Source of life scheduling theory, this seminar to establish with the kidney invigorating key medicine Radix Morindae Officinalis and Herba Epimedii as monarch drug, is equipped with the pure Chinese prescription health food of Fructus Lycii and Rhizoma Dioscoreae.
Based on this research and a kind of preparation method with Improving memory function tablet of development and Design.
Summary of the invention
The object of the invention is to: provide a kind of preparation method with Improving memory function tablet, this preparation method is simple, and is applicable to large-scale production and application.
The present invention is achieved through the following technical solutions: a kind of preparation method with Improving memory function tablet, comprises the following steps:
1) Herba Epimedii dry extract A is prepared;
2) take Rhizoma Dioscoreae powder, cross 60 mesh sieves, for subsequent use;
3) Radix Morindae Officinalis and Fructus Lycii extractum is prepared;
4) by Rhizoma Dioscoreae powder and step 3) Radix Morindae Officinalis that obtains and Fructus Lycii extractum mix, and vacuum drying, obtains mixing dry extract B;
5) by step 1) the Herba Epimedii dry extract A that obtains and step 4) the mixing dry extract B that obtains mixes, uses pulverizer to make powder, cross 100 mesh sieve, add microcrystalline Cellulose, mixing, uses 90% ethanol wet, make soft material, granulate, in 70 DEG C of oven dry, obtain dried particles, add lubricant, mixing, tabletting, to obtain final product.
Further, in order to better realize the present invention, also comprise following technical characteristic, described step 1) preparation process of preparing Herba Epimedii dry extract A is: gets epimedium herb, is placed in round-bottomed flask, add 80% edible ethanol of 13 times amount, reflux, extract, 1h after immersion 0.5h, extract 2 times, filter, merging filtrate, carry out reclaim under reduced pressure, obtain Herba Epimedii extract concentrated solution, in 60 DEG C of vacuum dryings, to obtain final product.
Further, in order to better realize the present invention, also comprise following technical characteristic, described step 3) prepare the method for Radix Morindae Officinalis and Fructus Lycii extractum for getting Radix Morindae Officinalis and Fructus Lycii, add 8 times amount distilled water, 100 DEG C are extracted 2h, add 3 times amount distilled water again, 100 DEG C are extracted 1h, extract 2 times, filter after extracting, merging filtrate, concentrated, add edible ethanol, sealing and standing.
Further, in order to better realize the present invention, also comprise following technical characteristic, described step 3) prepare the method for Radix Morindae Officinalis and Fructus Lycii extractum for getting Radix Morindae Officinalis and Fructus Lycii, add 8 times amount distilled water, 100 DEG C are extracted 2h, add 3 times amount distilled water again, 100 DEG C are extracted 1h, extract 2 times, filter after extracting, merging filtrate, concentrated, add edible ethanol, sealing and standing.
Further, in order to better realize the present invention, also comprise following technical characteristic, described step 5) in by Herba Epimedii dry extract A and mixing dry extract B mixing, and after pulverizing with pulverizer, adopt 100 mesh sieve.
Further, in order to better realize the present invention, also comprise following technical characteristic, described step 5) in granulate be adopted 20 eye mesh screens granulate.
Further, in order to better realize the present invention, also comprise following technical characteristic, described step 5) in obtain dried particles after, the lubricant added is magnesium stearate.
Experimental section:
1 prescription composition
Chinese crude drug: Herba Epimedii, Radix Morindae Officinalis, Fructus Lycii, Rhizoma Dioscoreae.
2 method for makings
2.1 Med Mat Appreciation
Herba Epimedii, Radix Morindae Officinalis, Rhizoma Dioscoreae, Fructus Lycii: pharmaceutcal corporation, Ltd is write in Guangzhou, Herba Epimedii is the dry aerial parts of berberine section plant Herba Epimedii EpimediumbrevicornumMaxim; Radix Morindae Officinalis is the dry meat root of Maguireothamnus speciosus Radix Morindae Officinalis MorindaofficinalisHow; Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum LyciumbarbarumL.; Rhizoma Dioscoreae is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae DioscoreaoppositaThunb..
The preparation of 2.2 medicines
2.2.1 epimedium herb is got in the preparation of Herba Epimedii dry extract, be placed in round-bottomed flask, add 80% edible ethanol of 13 times amount, reflux, extract, 1h after immersion 0.5h, extracts 2 times at every turn, filter, merging filtrate, merge extractive liquid, is evaporated to paste, put 60 DEG C of reduced vacuum dryings, obtain Herba Epimedii dry extract.
2.2.2 the dry extract preparation of Radix Morindae Officinalis, Fructus Lycii and Rhizoma Dioscoreae is got recipe quantity Rhizoma Dioscoreae and pulverized, cross 60 mesh sieves, for subsequent use.Get Radix Morindae Officinalis and Fructus Lycii, the distilled water of first time use 8 times amount, 100 DEG C are extracted 2h, then add the distilled water of 3 times amount, and 100 DEG C are extracted 1h, extract 2 times.Filter after extracting, merging filtrate, be concentrated into 720mL, edible ethanol to the alcohol precipitation concentration adding 95% is 90%, then sealing and standing 24h, incline supernatant, be recycled to without alcohol taste, obtain Radix Morindae Officinalis and Fructus Lycii mixed sediment, add Rhizoma Dioscoreae powder and precipitate mixes, be placed in 60 DEG C of vacuum dryings, obtain mixing dry extract B.
2.2.3 2 kinds of dry extracts that " 2.2.1 " item and " 2.2.2 " item obtain are merged, make powder with pulverizer, cross 100 mesh sieves, obtain medicine powder.
2.3 Study on Forming
2.3.1 the selection tablet of adjuvant is made up of medicine and adjuvant two parts.Adjuvant is the general name of all materials except principal agent in tablet, also known as excipient, is non-therapeutic material.The adjuvant of tablet generally comprises absorbent, diluent, wetting agent, adhesive, disintegrating agent and lubricant etc.In research, to guarantee that tablet has for the purpose of good hardness, disintegration time and hydroscopicity, screening is applicable to the accessory formula of film-making.
2.3.1.1 the selection of filler at present domestic comparatively conventional filler have soluble starch, Icing Sugar, dextrin, calcium sulfate, lactose etc.Though lactose no hygroscopicity, there is good compressibility, do not affect the stripping of medicine, smaller on the assay impact of principal agent, but price is more expensive.And microcrystalline Cellulose is dissolved in hot water, hygroscopicity is little, moderate, and is " dilution-bonding-disintegrate " multi-functional excipient, therefore selects microcrystalline Cellulose as filler.
2.3.1.2 containing a large amount of sugar in this prescription component of selection of wetting agent, if select water easily to cause as wetting agent difficulty of granulating because cohering.If select ethanol can overcome the granulation difficulty caused because medicine water solublity is comparatively large as wetting agent, and dry heated time can be shortened.Therefore select 90% ethanol as wetting agent.
2.3.1.3 the selection lubricant of lubricant conveniently feeds in raw material and tabletting, reduce the frictional force between granule, between granule and nib, between tablet and mould and the greasing substance that adds, comprise hydrophobic lubricant as Pulvis Talci, magnesium stearate etc., soluble oil is as PEG etc., and fluidizer is as micropowder silica gel etc.Domestic conventional magnesium stearate is lubricant, and its lubrication is good, can reduce the ejection force of tablet significantly, and prevent glutinous punching effect, significantly can improve the outward appearance of tablet.The lubricant of this product selects magnesium stearate equally.
2.3.2 the selection of coating material has stronger hygroscopicity usually due to Chinese medicinal tablet, avoids by coating, ensures the drug effect of tablet in the long period.Aqueous coatings can avoid the volatilization of organic solvent, makes the safety raising of production process, production cost reduction, is more conducive to environmental conservation; Meanwhile, the gelling temp needed for coating process is lower, and to effective ingredient, influence factor is less, has ingredient adaptability widely.Based on above-mentioned advantage, increasing pharmaceutical factory has turned to the thin film coating system of water-soluble.Water-soluble film coating material conventional at present comprises hydroxypropyl emthylcellulose (HPMC), hydroxypropyl cellulose (HPC), Polyethylene Glycol (PEG), polyvinylpyrrolidone (PVP) etc.This tablet also can use HPMC as coating material.
2.3.3 the determination of supplementary product consumption
2.3.3.1 instrument and reagent TDP-5 single punch tablet machine: Shanghai Tianfan Pharmaceutical Machinery Factory; XT220A ten thousand/balance: Precisa company; YPJ-200A type tablet hardness tester: Shanghai Huanghai Sea medicine inspection instrument company; ZB-2D type Intelligent disintegration tester: Huankai Microbes Tech Co., Ltd., Guangdong; Microcrystalline Cellulose; Magnesium stearate; Brain recalls source medicated powder: self-control, lot number 20100413,20100510,20100518.
2.3.3.2 method and result adopt the method for orthogonal test, and choose 2 factors: microcrystalline Cellulose consumption, magnesium stearate consumption, each factor gets 3 levels, as in table 1, investigates the factor affecting tablet moulding process.L9 (34) design table is selected to test.Often group is recalled source extractum with 10g brain and is entered corresponding adjuvant, and mixing, sprays 90% appropriate edible ethanol soft material, wet granulation, then put dry 120min in people's 70 DEG C of baking ovens.After taking-up, granule is crossed 20 mesh sieves, granulate, add magnesium stearate mixing, utilize tablet machine to carry out film-making.
Table 1
With the outward appearance of tablet, hardness, disintegration, mass discrepancy for evaluation index, the Forming Quality of comprehensive scoring method to the tablet by design formula preparation is adopted to carry out overall merit.Tablet appearance observes its integrity, smoothness, color and luster, color fiber crops speckle abnormal phenomenon, complete bright and clean, color equal, colourless numb speckle deformity 4 points; Complete bright and clean, color is equal, even coloured numb speckle deformity 3 points; Complete bright and clean, color is equal, coloured numb speckle deformity 2 points; Complete bright and clean, uneven 1 point of color; Imperfect bright and clean 0 point.Tablet hardness (kg) adopts former numerical value to be obatained score.Disintegration adopts 100 times of former numerical value inverse for obatained score.Mass discrepancy adopts 10 times of sheet heavy coefficient of variation percent inverse to be obatained score.When carrying out comprehensive grading with the maximum of each index for reference, data are normalized, then provide different weights.The weight coefficient of tablet hardness and disintegration is set to 0.3.Wherein comprehensive grading Y=0.2X1 × 100/4+0.3X2 × 100/5+0.3X3 × 100/5.6+0.2X4 × 100/23.5.
The higher expression mouldability of each index appraisal result is better.The best prescription meeting tablet Forming Quality and require is filtered out by appraisal result.
Observe and often organize the outward appearance that brain recalls source sheet, measure tablet hardness with tablet hardness tester, use disintegration tester to measure the disintegration of tablet, measure tablet weight variation with analytical balance, record indices result, calculates comprehensive grading.Variance analysis is carried out to test data as shown in table 2.Application comprehensive scoring method, the test data of testing 2 factors determined is analyzed, the data display of gained: affect in 2 factors of tablet molding, microcrystalline Cellulose and magnesium stearate there are no significant impact, in conjunction with the economic factor of producing and appraisal result, show that the optimum process condition that brain recalls source sheet moulding process is A1B3, namely brain recalls source extractum powder: microcrystalline Cellulose: magnesium stearate=10:0.8:0.3, and comprehensive grading is 84.01.Now the consumption of microcrystalline Cellulose is less, meets economic benefit, and now tablet all can reach good effect in outward appearance, disintegration, hardness and tablet weight variation etc., determines that these process conditions are optimised process.
Table 2
Concrete preparation technology: get epimedium herb, be placed in round-bottomed flask, add 80% edible ethanol of 13 times amount, reflux, extract, 1h after immersion 0.5h, extracts 2 times at every turn, filter, merging filtrate, carries out reclaim under reduced pressure, obtains Herba Epimedii extract concentrated solution, in 60 DEG C of vacuum dryings, obtain Herba Epimedii dry extract A for subsequent use.Get recipe quantity Rhizoma Dioscoreae to pulverize, cross 60 mesh sieves, for subsequent use.Get Radix Morindae Officinalis and Fructus Lycii, the distilled water of first time use 8 times amount, 100 DEG C are extracted 2h, add 3 times again and measure distilled water, 100 DEG C are extracted 1h, extract 2 times, filter after extracting, merging filtrate, is concentrated into 720mL, edible ethanol to the alcohol precipitation concentration adding 95% is 90%, then sealing and standing 24h, and incline supernatant, be recycled to without alcohol taste, obtain Radix Morindae Officinalis and Fructus Lycii mixing extractum, add Rhizoma Dioscoreae powder and mix extractum and mix, in 60 DEG C of vacuum dryings, obtain mixing dry extract B for subsequent use.A and B is mixed, uses pulverizer to make powder, cross 100 mesh sieves, add the amount of microcrystalline Cellulose 8% as adjuvant, mixing, with appropriate edible ethanol as wetting agent, makes soft material, granulate with 20 eye mesh screens, in 70 DEG C of oven dry, obtain dried particles, add the amount of magnesium stearate 3% as lubricant, mixing, tabletting.Obtain brain and recall source sheet.
The present invention compared with prior art, has the following advantages and beneficial effect:
Preparation technology of the present invention is relative to prior art, and prepared tablet all has good effect in outward appearance, disintegration, hardness and tablet weight variation, and cost is low, and economic benefit is good.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited thereto.
Embodiment 1:
Present embodiment discloses a kind of preparation method with Improving memory function tablet: get epimedium herb, be placed in round-bottomed flask, add 80% edible ethanol of 13 times amount, reflux, extract, 1h after immersion 0.5h, extracts 2 times at every turn, filter, merging filtrate, carries out reclaim under reduced pressure, obtains Herba Epimedii extract concentrated solution, in 60 DEG C of vacuum dryings, obtain Herba Epimedii dry extract A for subsequent use.Get recipe quantity Rhizoma Dioscoreae to pulverize, cross 60 mesh sieves, for subsequent use.Get Radix Morindae Officinalis and Fructus Lycii, the distilled water of first time use 8 times amount, 100 DEG C are extracted 2h, add 3 times again and measure distilled water, 100 DEG C are extracted 1h, extract 2 times, filter after extracting, merging filtrate, is concentrated into 720mL, edible ethanol to the alcohol precipitation concentration adding 95% is 90%, then sealing and standing 24h, and incline supernatant, be recycled to without alcohol taste, obtain Radix Morindae Officinalis and Fructus Lycii mixing extractum, add Rhizoma Dioscoreae powder and mix extractum and mix, in 60 DEG C of vacuum dryings, obtain mixing dry extract B for subsequent use.A and B is mixed, uses pulverizer to make powder, cross 100 mesh sieves, add the amount of microcrystalline Cellulose 8% as adjuvant, mixing, with appropriate edible ethanol as wetting agent, make soft material, sieve, dry, obtain dried particles, add the amount of magnesium stearate 3% as lubricant, mixing, tabletting.
Embodiment 2:
Present embodiment discloses a kind of preparation method with Improving memory function tablet, get epimedium herb, be placed in round-bottomed flask, add 80% edible ethanol of 13 times amount at every turn, reflux, extract, 1h after immersion 0.5h, extract 2 times, filter, merging filtrate, carry out reclaim under reduced pressure, obtain Herba Epimedii extract concentrated solution, in 60 DEG C of vacuum dryings, obtain Herba Epimedii dry extract A for subsequent use.Get recipe quantity Rhizoma Dioscoreae to pulverize, cross 60 mesh sieves, for subsequent use.Get Radix Morindae Officinalis and Fructus Lycii, the distilled water of first time use 8 times amount, 100 DEG C are extracted 2h, add 3 times again and measure distilled water, 100 DEG C are extracted 1h, extract 2 times, filter after extracting, merging filtrate, is concentrated into 720mL, edible ethanol to the alcohol precipitation concentration adding 95% is 90%, then sealing and standing 24h, and incline supernatant, be recycled to without alcohol taste, obtain Radix Morindae Officinalis and Fructus Lycii mixing extractum, add Rhizoma Dioscoreae powder and mix extractum and mix, in 60 DEG C of vacuum dryings, obtain mixing dry extract B for subsequent use.A and B is mixed, uses pulverizer to make powder, cross 100 mesh sieves, add the amount of microcrystalline Cellulose 8% as adjuvant, mixing, with appropriate edible ethanol as wetting agent, makes soft material, cross 20 mesh sieves to granulate, 70 DEG C of oven dry, obtain dried particles, add the amount of magnesium stearate 3% as lubricant, mixing, tabletting.
The above is only preferred embodiment of the present invention, and not do any pro forma restriction to the present invention, every any simple modification, equivalent variations done above embodiment according to technical spirit of the present invention, all falls within protection scope of the present invention.
Claims (6)
1. there is a preparation method for Improving memory function tablet, it is characterized in that, comprise the following steps:
1) Herba Epimedii dry extract A is prepared;
2) take Rhizoma Dioscoreae powder, cross 60 mesh sieves, for subsequent use;
3) Radix Morindae Officinalis and Fructus Lycii extractum is prepared;
4) Radix Morindae Officinalis Rhizoma Dioscoreae powder and step 3) obtained and Fructus Lycii extractum mix, vacuum drying, obtain mixing dry extract B;
5) the mixing dry extract B that Herba Epimedii dry extract A step 1) obtained and step 4) obtain mixes, and uses pulverizer to make powder, crosses 100 mesh sieves, add microcrystalline Cellulose, mixing, uses 90% ethanol wet, make soft material, granulate, in 70 DEG C of oven dry, obtain dried particles, add lubricant, mixing, tabletting, to obtain final product.
2. a kind of preparation method with Improving memory function tablet according to claim 1, it is characterized in that: the preparation process that described step 1) prepares Herba Epimedii dry extract A is: get epimedium herb, be placed in round-bottomed flask, add 80% edible ethanol of 13 times amount, reflux, extract, 1h after immersion 0.5h, extract 2 times, filter, merging filtrate, carry out reclaim under reduced pressure, obtain Herba Epimedii extract concentrated solution, in 60 DEG C of vacuum dryings, to obtain final product.
3. a kind of preparation method with Improving memory function tablet according to claim 1, it is characterized in that: described step 3) prepares the method for Radix Morindae Officinalis and Fructus Lycii extractum for getting Radix Morindae Officinalis and Fructus Lycii, adds 8 times amount distilled water, 100 DEG C are extracted 2h, add 3 times amount distilled water again, 100 DEG C are extracted 1h, extract 2 times, filter after extracting, merging filtrate, concentrated, add edible ethanol, sealing and standing.
4. a kind of preparation method with Improving memory function tablet according to claim 3, it is characterized in that: in described step 3), in merging filtrate, filtrate is concentrated into 720ml, adding 95% edible ethanol to alcohol precipitation concentration is 90%, then sealing and standing 24h, incline supernatant, be recycled to without alcohol taste, namely obtain Radix Morindae Officinalis and Fructus Lycii mixing extractum.
5. a kind of preparation method with Improving memory function tablet according to claim 4, is characterized in that: granulating in described step 5) is adopted 20 eye mesh screens to granulate.
6. a kind of preparation method with Improving memory function tablet according to claim 5, it is characterized in that: after obtaining dried particles in described step 5), the lubricant added is magnesium stearate.
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| CN115804453A (en) * | 2022-12-20 | 2023-03-17 | 吉林大学 | Epimedium lipid-lowering tablet and preparation method thereof |
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Application publication date: 20151223 |