CN108030827A - A kind of pink SIWU KELI and preparation method thereof - Google Patents
A kind of pink SIWU KELI and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61K2236/50—Methods involving additional extraction steps
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Abstract
The invention discloses a kind of pink SIWU KELI and preparation method thereof, the raw material of pink SIWU KELI includes by weight：250 350 parts of peach kernel, 150 250 parts of safflower, 250 350 parts of Angelica sinensis, 350 450 parts of prepared rhizome of rehmannia, 150 250 parts of Ligusticum wallichii, 250 350 parts of Radix Paeoniae Alba, 640 740 parts of diluent, 5 25 parts of flavouring.A kind of pink SIWU KELI proposed by the present invention and preparation method thereof, active skull cap components content is high in pink SIWU KELI, and compatibility is good, expands and takes target user, and has good mouldability and stability, is easy to large-scale production.
Description
Technical field
The present invention relates to field of pharmaceutical technology, more particularly to a kind of pink SIWU KELI and preparation method thereof.
Background technology
Dysmenorrhoea, is the common sympton for perplexing women physical and mental health.Female friend is innately sensitive, sensitive, along with just
The complicated factors such as industry pressure, social status, family's pressure, interpersonal relationships, thus it is often very impatient, hindered by feelings will；
And the traditional Chinese medical science thinks that women belongs to cloudy, modern female movement is few, and the cold and cool food intake such as fruit is excessive in diet, it is easier to causes constitution
It is partially cold；Both interactions, cause blood to tremble with fear and coagulate, or qi depression to blood stasis, and vessels of the uterus is appointed in blood-stasis internal-depression punching, not general rule pain, so in the moon
When through coming, trigger dysmenorrhoea.
《2015 Chinese women physiological health white paper》Point out there is the women close to 80% with slight and the above pain
Through wherein the menalgia more than 14% has an impact normal life.For dysmenorrhoea, the women close to half does not take any arrange
Apply.Unmarried female dysmenorrhoea situation is more serious than the women educated among these.
Pink four thing is derived, original side as traditional gynaecology's classic prescriptions promoting blood circulation and removing blood stasis by traditional Chinese medical science ancient prescription Siwu Tang
Come from Qing Dynasty Wu Qian《Yizong Jinjian》, it is made of peach kernel, safflower, Ligusticum wallichii, Angelica sinensis, Radix Paeoniae Alba, prepared rhizome of rehmannia Six-element medicine.Full side is with dissolving stasis
For core, it is aided with blood-nourishing, promoting the circulation of qi.In side based on the product peach kernel of powerful blood-breaking, safflower, advocate promoting blood circulation and removing blood stasis；With sweet temperature it
Cultivated land, Angelica sinensis enriching yin tonifying liver, nourishing blood for regulating menstruation；Chinese herbaceous peony blood-nourishing and battalion, to augment the power of blood；Ligusticum wallichii blood-activating and qi-promoting, adjust smooth qi and blood, with
Help the work(of promoting blood circulation.Complete square compatibility 5 is proper, hemostasis is dispelled, new blood is raw, mechanism of qi is smooth, and blood stasis dispersing and fresh blood promoting is the distinguishing feature of the party.Promoting blood circulation
Blood-nourishing, blood-activating analgetic, tonification and purgation in combination；Irregular menstruation, dysmenorrhoea, amenorrhoea caused by treatment blood stasis, uterine bleeding can many gynaecology's diseases.
Traditional Chinese medicine is in preparation process is extracted, and for majority using adding water to cook, paste volume is big, and dose is also big, it is sent out
Exhibition brings inconvenience.The separation methods such as the overcritical, ultrafiltration that develops in recent years, membrane filtration, macroreticular resin, to a certain degree
On solve the problems, such as loss of effective components, but unavoidably there are it is cumbersome, man-hour is long, technique is unstable, increase is produced into
This problems such as.In addition high equipment cost, safeguards inconvenience, and the regeneration of film/resin can bring new environmental pollution.And Chinese medicine effectively into
Divide complexity, to damp and hot sensitivity, there are unstable, quality heterogeneity problem for traditional preparation so that modernization of Chinese medicine layout is slow.
Dry granulation is a kind of new method of granulating to grow up after Boiling Fuel Injection Spray granulation, is particularly suitable for water, temperature-sensitive
The medicine of sense, can reduce contact of the material with water and heat to greatest extent, improve the stability of preparation, overcome wet granulation and boiling
Rise the deficiency of granulation.Be not required to compared with traditional granulating process, in dry granulation process plus binder, eliminate mixing softwood,
The processes such as drying, whole grain, shorten process route and production cycle, have saved cost, meet the circulation warp that country strongly advocates
The fundamental state policy of Ji.Dry granulation technology is abroad with exclusive excellent such as low, the efficient, energy conservation and environmental protection of its production cost at present
Gesture, has been widely used in the industries such as food, chemical industry and pharmacy, but the country is due to limited conditions, and the research to dry granulation rises
Later, particularly Chinese herbal medicine industry is walked, since dry granulation has the defects of glutinous wheel, ratio of briquetting are low, square mobility of particle is poor, limit
Its development and application are made.
《World Health Organization's diabetes country profile in 2016》Middle display China is every year because diabetes and hyperglycaemia are dead
The number died nearly 1,000,000 people, wherein women accounting 56%.Nearest investigation shows that the whole world is fat more than 600,000,000 people, Chinese
Population of being obese ranks the first in the world, and possesses 46,400,000 Obese Womens, accounts for the 12.4% of the whole world.Dysmenorrhoea diabetes, hyperglycaemia with
And in Obese Women crowd be generally existing, due to the shortage of domestic and international sugar-free formulation, cause the patients such as diabetes to use
Medicine range of choice narrows, or while taking related medicine need to be combined antidiabetic drug, in order to avoid cause blood glucose rise, aggravates diabetes or into one
The fat probability of step increase.On the one hand drug combination has aggravated the financial burden of patient, on the other hand there may be drug effect conflict or
The situation that drug effect reduces, substantially increases the uncertainty of drug safety.
Production and the defects of clinically these are apparent so that those skilled in the art is highly desirable to be changed using physical property
Property technology, develop a kind of improved high-efficiency preparation technique so that be difficult to the herbal species of dry granulation, be easy to scale metaplasia
Production, expands the pink SIWU KELI of target user.
The content of the invention
Based on technical problem existing for background technology, the present invention proposes a kind of pink SIWU KELI and preparation method thereof,
Active skull cap components content is high in pink SIWU KELI, and compatibility is good, expands and takes target user, and has good shaping
Property and stability, are easy to large-scale production.
A kind of pink SIWU KELI proposed by the present invention, its raw material include by weight：250-350 parts of peach kernel, safflower
150-250 parts, 250-350 parts of Angelica sinensis, 350-450 parts of prepared rhizome of rehmannia, 150-250 parts of Ligusticum wallichii, 250-350 parts of Radix Paeoniae Alba, diluent
640-740 parts, 5-25 parts of flavouring.
In embodiment, the parts by weight of peach kernel can also be 265,280,300,315,330,340 parts, the weight of safflower
It can also be 165,180,200,215,230,240 parts to measure part, the parts by weight of Angelica sinensis can also be 265,280,300,315,
330th, 340 parts, the parts by weight of prepared rhizome of rehmannia can also be 365,380,400,415,430,440 parts, and the parts by weight of Ligusticum wallichii can be with
For 165,180,200,215,230,240 parts, the parts by weight of Radix Paeoniae Alba can also be 265,280,300,315,330,340 parts, dilute
The parts by weight for releasing agent can also be 650,665,680,700,715,730,740 parts, the parts by weight of flavouring can also be 8,10,
12nd, 15,18,22 parts.
Preferably, its raw material includes by weight：300 parts of peach kernel, 200 parts of safflower, 300 parts of Angelica sinensis, 400 parts of prepared rhizome of rehmannia,
200 parts of Ligusticum wallichii, 300 parts of Radix Paeoniae Alba, 700 parts of diluent, 8 parts of flavouring.
Preferably, diluent is made of at least one of dextrin, soluble starch, lactose, mannitol.
Preferably, diluent is by weight 1-3 by dextrin, soluble starch:1-5 is formed.
Preferably, diluent is 1 by weight by dextrin, soluble starch:2 compositions.
Preferably, flavouring is by Aspartame, neotame, Steviosin, Sucralose, xylitol, sweet Momordica grosvenori, glycyrrhizin
At least one of element, lactitol, thaumati, maltitol, one potassium of glycyrrhizic acid, tripotassium glycyrrhetate form.
Preferably, flavouring is Steviosin and/or Sucralose.
Preferably, the content of Steviosin is 1-5wt% in pink SIWU KELI.
Preferably, the content of Steviosin is 2.5wt% in pink SIWU KELI.
Preferably, the content of Sucralose is 0.5-1wt% in pink SIWU KELI.
Preferably, the content of Sucralose is 0.8wt% in pink SIWU KELI.
A kind of preparation method for pink SIWU KELI that the present invention also proposes, comprises the following steps：
S1, by peach kernel, safflower, Angelica sinensis, prepared rhizome of rehmannia, Ligusticum wallichii, Radix Paeoniae Alba mix, add water to cook, merging filtrate, concentrate, vacuum
Dry, sieving, obtains dried cream powder；
S2, mix diluent with flavouring, adds dried cream powder, stirs, and pelletizes, and packaging, obtains pink SIWU KELI.
Preferably, in S1, peach kernel, safflower, Angelica sinensis, prepared rhizome of rehmannia, Ligusticum wallichii, Radix Paeoniae Alba is mixed, put into multi-function extractor,
Add 10-15 times and measure water decoction three times, each 1.5-2.5h, merging filtrate, it is 1.10 ± 0.15 to be concentrated into relative density, vacuum
Freeze-drying, crosses 60-100 mesh sieves, obtains dried cream powder.
Preferably, in S1, peach kernel, safflower, Angelica sinensis, prepared rhizome of rehmannia, Ligusticum wallichii, Radix Paeoniae Alba is mixed, put into multi-function extractor,
12 times of amount water are added to decoct three times, each 2h, merging filtrate, it is 1.10 ± 0.05 to be concentrated into relative density, vacuum freeze drying,
80 mesh sieves are crossed, obtain dried cream powder.
Preferably, in S1, relative density numerical value is the measured value under 65 DEG C of temperature conditionss.
Preferably, in S2, diluent is crossed into 80 mesh sieves, is then placed in mixer and mixes with flavouring, add dry cream
Powder, stirring are mixed, and are subsequently placed in dry granulating machine and pelletize, and choose the granule packaging that granularity is 14-60 mesh, obtain pink four thing
Particle.
Compared with conventional granulates agent technique, the present invention has the following advantages the present invention：
Diluent components and proportioning are improved, material hygroscopicity is reduced, effectively overcomes traditional Chinese medicinal extract powder to be deposited in dry granulation
Glutinous wheel, the problem such as low, the square mobility of particle difference of ratio of briquetting so that pelletization is smooth easy, have correspondingly work
Skill route and production cycle.
Classics recipe is passed on, ancient method extraction is continued to use, can more retain active ingredient, Chinese medicine especially compound active ingredient is answered
It is miscellaneous, avoid extracting loss as caused by the extractive techniques such as supercritical extract, water extract-alcohol precipitation, simple process is easy, protects to greatest extent
Hold genuineness.
Dry extract is made using vacuum freeze drying mode, reduces spray drying and traditional drying mode to wet in prescription
The influence of thermally sensitive composition, especially has safflower component hydroxyl radical carthamin yellow carthamus A promoting blood circulation and removing blood stasis in we.
Meanwhile granule of the present invention uses dextrin, soluble starch etc. to be used as diluent, without sucrose, in keeping original
The characteristic of medicine classic prescriptions, while passing on ancient prescription, by improving and optimizating prescription diluent, expands patient's scope of application, enriches
The selection of the hyperglycaemia patient medications such as diabetes.By being properly added flavouring, avoid because of the shortage of the sweet taste diluent such as sucrose
The bitterness sense brought, significantly improves patient's mouthfeel, improves patient compliance.
Brief description of the drawings
Fig. 1 is the preparation technology flow chart of pink SIWU KELI in embodiment 1；
Fig. 2 is the sucting wet curve figure of the dried cream powder of different diluent proportionings in embodiment 1；
Fig. 3 is the moisture absorption matched curve figure of the dried cream powder of different diluent proportionings in embodiment 1；
Fig. 4 is the sucting wet curve figure of the dried cream powder of different diluent proportionings after optimizing in embodiment 1；
Fig. 5 is the moisture absorption matched curve figure of the dried cream powder of different diluent proportionings after optimizing in embodiment 1；
Fig. 6 is pink SIWU KELI sucting wet curve figure under different humidity in embodiment 1.
Embodiment
In the following, technical scheme is described in detail by specific embodiment.
Embodiment 1
A kind of pink SIWU KELI proposed by the present invention, its raw material include by weight：300 parts of peach kernel, 200 parts of safflower,
300 parts of Angelica sinensis, 400 parts of prepared rhizome of rehmannia, 200 parts of Ligusticum wallichii, 300 parts of Radix Paeoniae Alba, 423 parts of dextrin, 221.5 parts of soluble starch, Steviosin
25 parts.
With reference to the preparation method of Fig. 1, the present invention a kind of pink SIWU KELI also proposed, comprise the following steps：
S1, by peach kernel, safflower, Angelica sinensis, prepared rhizome of rehmannia, Ligusticum wallichii, Radix Paeoniae Alba mix, put into multi-function extractor in, add 12 times
Measure water to decoct three times, each 2h, merging filtrate, it is 1.10 (hot testing temperature is 65 DEG C) to be concentrated into relative density, and vacuum refrigeration is done
It is dry, 80 mesh sieves are crossed, obtain dried cream powder；
S2, by dextrin and soluble starch cross 80 mesh sieves, is then placed in mixer and mixes with flavouring, adds dry cream
Powder, stirring are mixed, and are subsequently placed in dry granulating machine and pelletize, and choose the granule packaging that granularity is 14-60 mesh, every bag of 10g, obtains
Pink SIWU KELI.
Embodiment 2
A kind of pink SIWU KELI proposed by the present invention, its raw material include by weight：300 parts of peach kernel, 200 parts of safflower,
300 parts of Angelica sinensis, 400 parts of prepared rhizome of rehmannia, 200 parts of Ligusticum wallichii, 300 parts of Radix Paeoniae Alba, 423 parts of dextrin, 221.5 parts of soluble starch, trichlorine sugarcane
8 parts of sugar.
A kind of preparation method for pink SIWU KELI that the present invention also proposes, comprises the following steps：
S1, by peach kernel, safflower, Angelica sinensis, prepared rhizome of rehmannia, Ligusticum wallichii, Radix Paeoniae Alba mix, put into multi-function extractor in, add 12 times
Measure water to decoct three times, each 2h, merging filtrate, it is 1.10 (hot testing temperature is 65 DEG C) to be concentrated into relative density, and vacuum refrigeration is done
It is dry, 80 mesh sieves are crossed, obtain dried cream powder；
S2, by dextrin and soluble starch cross 80 mesh sieves, is then placed in mixer and mixes with flavouring, adds dry cream
Powder, stirring are mixed, and are subsequently placed in dry granulating machine and pelletize, and choose the granule packaging that granularity is 14-60 mesh, every bag of 10g, obtains
Pink SIWU KELI.
Embodiment 3
A kind of pink SIWU KELI proposed by the present invention, its raw material include by weight：300 parts of peach kernel, 200 parts of safflower,
300 parts of Angelica sinensis, 400 parts of prepared rhizome of rehmannia, 200 parts of Ligusticum wallichii, 300 parts of Radix Paeoniae Alba, 318 parts of dextrin, 318 parts of soluble starch, Steviosin 25
Part.
A kind of preparation method for pink SIWU KELI that the present invention also proposes, comprises the following steps：
S1, by peach kernel, safflower, Angelica sinensis, prepared rhizome of rehmannia, Ligusticum wallichii, Radix Paeoniae Alba mix, put into multi-function extractor in, add 12 times
Measure water to decoct three times, each 2h, merging filtrate, it is that 1.10 hot testing temperatures are 65 DEG C to be concentrated into relative density), vacuum refrigeration is done
It is dry, 80 mesh sieves are crossed, obtain dried cream powder；
S2, by dextrin and soluble starch cross 80 mesh sieves, is then placed in mixer and mixes with flavouring, adds dry cream
Powder, stirring are mixed, and are subsequently placed in dry granulating machine and pelletize, and choose the granule packaging that granularity is 14-60 mesh, every bag of 10g, obtains
Pink SIWU KELI.
Embodiment 4
A kind of pink SIWU KELI proposed by the present invention, its raw material include by weight：300 parts of peach kernel, 200 parts of safflower,
300 parts of Angelica sinensis, 400 parts of prepared rhizome of rehmannia, 200 parts of Ligusticum wallichii, 300 parts of Radix Paeoniae Alba, 318 parts of dextrin, 318 parts of soluble starch, Sucralose 8
Part.
A kind of preparation method for pink SIWU KELI that the present invention also proposes, comprises the following steps：
S1, by peach kernel, safflower, Angelica sinensis, prepared rhizome of rehmannia, Ligusticum wallichii, Radix Paeoniae Alba mix, put into multi-function extractor in, add 12 times
Measure water to decoct three times, each 2h, merging filtrate, it is 1.10 (hot testing temperature is 65 DEG C) to be concentrated into relative density, and vacuum refrigeration is done
It is dry, 80 mesh sieves are crossed, obtain dried cream powder；
S2, by dextrin and soluble starch cross 80 mesh sieves, is then placed in mixer and mixes with flavouring, adds dry cream
Powder, stirring are mixed, and are subsequently placed in dry granulating machine and pelletize, and choose the granule packaging that granularity is 14-60 mesh, every bag of 10g, obtains
Pink SIWU KELI.
Embodiment 5
A kind of pink SIWU KELI proposed by the present invention, its raw material include by weight：250 parts of peach kernel, 150 parts of safflower,
250 parts of Angelica sinensis, 450 parts of prepared rhizome of rehmannia, 150 parts of Ligusticum wallichii, 250 parts of Radix Paeoniae Alba, 640 parts of diluent, 25 parts of flavouring.
Wherein, diluent is made of lactose and mannitol；
Flavouring is made of the mixing of Aspartame, neotame, xylitol and sweet Momordica grosvenori.
A kind of preparation method for pink SIWU KELI that the present invention also proposes, comprises the following steps：
S1, by peach kernel, safflower, Angelica sinensis, prepared rhizome of rehmannia, Ligusticum wallichii, Radix Paeoniae Alba mix, put into multi-function extractor in, add 10 times
Measure water to decoct three times, each 1.5h, merging filtrate, it is 0.95 (hot testing temperature is 65 DEG C) to be concentrated into relative density, vacuum refrigeration
It is dry, 60 mesh sieves are crossed, obtain dried cream powder；
Diluent, is crossed 80 mesh sieves by S2, is then placed in mixer and is mixed with flavouring, adds dried cream powder, and stirring is mixed
, it is subsequently placed in dry granulating machine and pelletizes, chooses the granule packaging that granularity is 20-60 mesh, obtain pink SIWU KELI.
Embodiment 6
A kind of pink SIWU KELI proposed by the present invention, its raw material include by weight：350 parts of peach kernel, 250 parts of safflower,
350 parts of Angelica sinensis, 350 parts of prepared rhizome of rehmannia, 250 parts of Ligusticum wallichii, 350 parts of Radix Paeoniae Alba, 740 parts of diluent, 5 parts of flavouring.
Wherein, diluent is made of soluble starch, lactose, mannitol mixing；
Flavouring is made of Steviosin, Sucralose；
A kind of preparation method for pink SIWU KELI that the present invention also proposes, comprises the following steps：
S1, by peach kernel, safflower, Angelica sinensis, prepared rhizome of rehmannia, Ligusticum wallichii, Radix Paeoniae Alba mix, put into multi-function extractor in, add 15 times
Measure water to decoct three times, each 2.5h, merging filtrate, it is 1.25 to be concentrated into relative density, and vacuum freeze drying, crosses 100 mesh sieves, obtain
To dried cream powder；
Diluent, is crossed 80 mesh sieves by S2, is then placed in mixer and is mixed with flavouring, adds dried cream powder, and stirring is mixed
, it is subsequently placed in dry granulating machine and pelletizes, chooses the granule packaging that granularity is 20-50 mesh, obtain pink SIWU KELI.
For effect more caused by the visual representation present invention, gained extract powder in Example 1, according to《Medicine draws wet
Property test direction principle》Measure pink four things dry extract and from the mixed hygroscopicity of different diluents.
Dry tool plug glass measuring cup (outside diameter 50mm, a height of 15mm) is taken to be placed in suitable constant temperature incubation in the previous day
In case (design temperature is 25 DEG C ± 1 DEG C, and relative humidity is 75% ± 2%), precise weighing.Take and be mixed with the pink of diluent in right amount
Four thing dried cream powders, put and 48h are dried in drier to constant-quality.Be put into the measuring cup bottom of constant-quality thickness about 1mm and
The pink four things dried cream powder of different diluent proportionings, is shown in Table 1, and accurate weighed quality is placed in above-mentioned constant incubator, is weighed
Bottle cap is opened, respectively at 0,6,12,24,48,72h timing precision weighings, Moisture percentage is calculated as follows.
Moisture percentage (%)=[quality before (quality before quality-moisture absorption after moisture absorption)/moisture absorption] × 100%
The proportioning of 1 dried cream powder of table and different diluents
Fuchsin(e)test the results are shown in Table 2：
The dried cream powder Moisture percentage of the different diluent proportionings of table 2
By 2 the data obtained of table, draw the humidity exposure time curve (see attached drawing 2) of the dried cream powder of different diluent proportionings and be fitted
Curve (see attached drawing 3), after understanding that pink four things dried cream powder adds corresponding diluent by attached drawing 2,3, hygroscopicity has to some extent
Improve, the moisture sorption effect order of each diluent is lactose ＜ soluble starch ＜ dextrin.
With reference to the dried cream powder solid powder face shaping and pelletizing forming after the different diluents of addition, evaluation table is observed
Bright, lactose and soluble starch can significantly improve the hygroscopicity of pink four things dried cream powder, but lactose is expensive, be not suitable for a large amount of
Addition, and 90% crowd of China limits the application of lactose there are lactose intolerance situation.Soluble starch grain forming side
Face is not so good as dextrin, to sum up it is contemplated that further optimization diluent matches, investigates soluble starch with dextrin composition to pink four
Thing dried cream powder hygroscopicity and mouldability influence, and improve the problems such as glutinous wheel shaping is poor.
In order to further improve the hygroscopicity and mouldability in dried cream powder dry granulation process, optimization diluent proportioning, is surveyed
Determine Moisture percentage, be shown in Table 3：
Diluent+dried cream powder after table 3 optimizes matches
After fuchsin(e)test, measurement result is shown in Table 4：
Diluent+dried cream powder after table 4 optimizes matches Moisture percentage
By 4 the data obtained of table, draw the humidity exposure time curve (see attached drawing 4) of the dried cream powder of different diluent proportionings and be fitted
Curve (see attached drawing 5), after the diluent after pink four things dried cream powder addition proportion optimizing is understood by attached drawing 4,5, hygroscopicity has aobvious
Writing, which improves ground, improves, wherein among the diluent of addition, dextrin and soluble starch ratio reach 1：When 3, pink four thing is done
Cream powder Moisture percentage is by initially the 7.95% of agent is down to 4.35% without dilution, during dry granulation experiment, material
Glutinous wheel phenomenon is greatly improved, and energy dog meets production needs, but there is a situation where that mouldability is low.In contrast, when dextrin with
Soluble starch ratio reaches 1：When 2, glutinous wheel phenomenon and mouldability are balanced well, and grain forming rate can reach 76%,
Post forming rate reaches 90%, therefore selects dried cream powder：(dextrin：Soluble starch=1：2)=70：30 proportionings, as pink
The preferred feed of SIWU KELI dry granulation, overcomes glutinous wheel and insufficient formability that this product produces in dry granulation process and asks
Topic, is adapted to the extensive efficiently production of industrialization, shortens the production cycle, save energy resources, contribute to the modernization of Chinese medicine to develop.
Different embodiment granules compare
According to the preparation method described in embodiment 1,2,3,4, a collection of pink SIWU KELI is respectively prepared, from appearance, moisture, grain
Degree, melting etc. are compared, and the results are shown in Table 5：
The different embodiment granules of table 5 compare
Gained Particles at Critical relative humidity measures：
The 1 pink SIWU KELI of gained of gained embodiment is taken, it is accurately weighed, the measuring cup bottom of constant-quality is put into, is put
In filling respectively in the drier of supersaturated solution (being shown in Table 6) of 7 kinds of various concentrations sulfuric acid and different salt, in 25 DEG C of freeze-day with constant temperature
Kept for 7 days in case, Moisture percentage that is accurately weighed and trying to achieve pink SIWU KELI finished product under different relative humidity, analyzes it and face
Boundary's relative humidity, sucting wet curve of mapping to obtain (see Fig. 6)
Pink SIWU KELI Moisture percentage under 6 different humidity of table
Table 6 and Fig. 6 show that pink SIWU KELI is almost non-hygroscopic when compared with low relative humidity, but when humidity increases to certain
After one numerical value, balance Moisture absorption rate sharply increases.As shown in Figure 6, sucting wet curve minimum point and peak are done into tangent line, two tangent lines
The intersecting critical relative moisture up to pink SIWU KELI, its critical relative moisture is about 63% after measured, sample moisture absorption at this time
Property is relatively low.Therefore, be the quality and stability that ensures said preparation, the production of pink SIWU KELI preparation and storage environment it is opposite
Humidity should be less than 63%.
Above-mentioned experiment shows, using 1,2,3,4 preparation method of the embodiment described, can prepare satisfactory pink
SIWU KELI agent.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (9)
1. a kind of pink SIWU KELI, it is characterised in that its raw material includes by weight：250-350 parts of peach kernel, safflower 150-
250 parts, 250-350 parts of Angelica sinensis, 350-450 parts of prepared rhizome of rehmannia, 150-250 parts of Ligusticum wallichii, 250-350 parts of Radix Paeoniae Alba, diluent 640-740
Part, 5-25 parts of flavouring.
2. pink SIWU KELI according to claim 1, it is characterised in that its raw material includes by weight：300 parts of peach kernel,
200 parts of safflower, 300 parts of Angelica sinensis, 400 parts of prepared rhizome of rehmannia, 200 parts of Ligusticum wallichii, 300 parts of Radix Paeoniae Alba, 700 parts of diluent, 8 parts of flavouring.
3. pink SIWU KELI according to claim 1 or claim 2, it is characterised in that flavouring is by Aspartame, neotame, stevia rebaudianum
Element, Sucralose, xylitol, sweet Momordica grosvenori, glycyrrhizin, lactitol, thaumati, maltitol, one potassium of glycyrrhizic acid,
At least one of tripotassium glycyrrhetate forms.
4. pink SIWU KELI according to claim 1 or claim 2, it is characterised in that diluent is by dextrin, soluble starch, breast
At least one of sugar, mannitol composition.
5. pink SIWU KELI according to claim 4, it is characterised in that diluent by dextrin, soluble starch by weight
Than for 1-3:1-5 is formed.
A kind of 6. preparation method of SIWU KELI pink according to any one of claim 1-5, it is characterised in that including with
Lower step：
S1, by peach kernel, safflower, Angelica sinensis, prepared rhizome of rehmannia, Ligusticum wallichii, Radix Paeoniae Alba mix, add water to cook, merging filtrate, concentrate, vacuum drying,
Sieving, obtains dried cream powder；
S2, mix diluent with flavouring, adds dried cream powder, stirs, and pelletizes, and packaging, obtains pink SIWU KELI.
7. the preparation method of pink SIWU KELI according to claim 6, it is characterised in that in S1, by peach kernel, safflower, when
Return, prepared rhizome of rehmannia, Ligusticum wallichii, Radix Paeoniae Alba mixing, put into multi-function extractor in, add 10-15 times measure water decoct three times, each 1.5-
2.5h, merging filtrate, it is 1.10 ± 0.15 to be concentrated into relative density, and vacuum freeze drying, crosses 60-100 mesh sieves, obtain dry cream
Powder.
8. the preparation method of pink SIWU KELI according to claim 6, it is characterised in that in S1, by peach kernel, safflower, when
Return, prepared rhizome of rehmannia, Ligusticum wallichii, Radix Paeoniae Alba mixing, put into multi-function extractor in, add 12 times amount water decoct three times, each 2h, merge filter
Liquid, it is 1.10 ± 0.05 to be concentrated into relative density, and vacuum freeze drying, crosses 80 mesh sieves, obtain dried cream powder.
9. the preparation method of pink SIWU KELI according to claim 6, it is characterised in that in S2, diluent is crossed into 80 mesh
Sieve, is then placed in mixer with flavouring and mixes, add dried cream powder, stirring is mixed, and is subsequently placed in dry granulating machine and makes
Grain, chooses the granule packaging that granularity is 14-60 mesh, obtains pink SIWU KELI.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109771494A (en) * | 2019-03-23 | 2019-05-21 | 程根群 | The Chinese medicine composition and preparation method for treating irregular shedding of endometrium and bleeding |
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| CN105616680A (en) * | 2014-11-07 | 2016-06-01 | 安徽中医药大学 | Peach seed-safflower Siwu granule originated from peach seed-safflower Siwu decoction, and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105616680A (en) * | 2014-11-07 | 2016-06-01 | 安徽中医药大学 | Peach seed-safflower Siwu granule originated from peach seed-safflower Siwu decoction, and preparation method thereof |
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| CN109771494A (en) * | 2019-03-23 | 2019-05-21 | 程根群 | The Chinese medicine composition and preparation method for treating irregular shedding of endometrium and bleeding |
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Application publication date: 20180515 |