CN105168742A - Making method of health food - Google Patents
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- CN105168742A CN105168742A CN201510489486.4A CN201510489486A CN105168742A CN 105168742 A CN105168742 A CN 105168742A CN 201510489486 A CN201510489486 A CN 201510489486A CN 105168742 A CN105168742 A CN 105168742A
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Abstract
The invention discloses a making method of a health food. The method includes: preparing Epimedium dry extract A; weighing yam rhizome powder, and sieving it with a 60-mesh sieve for standby; adding 8 times of distilled water into Morinda root and Chinese wolfberry fruit, extracting them at 100 DEG C for 2 h, adding 3 times of distilled water, performing extracting twice at 100 DEG C for 1 h, performing filtering, combining filtrates, concentrating a combination, adding edible alcohol, and allowing standing in a hermetic state to obtain Morinda officinalis and Chinese wolfberry extract; mixing the yam rhizome powder with the Morinda officinalis and Chinese wolfberry extract obtained in the step 3, and performing vacuum drying to obtain mixed dry extract B; mixing the Epimedium dry extract A obtained in the step 1 and the Morinda officinalis and Chinese wolfberry extract obtained in the step 4, crushing a mixture with a crusher to obtain powder, sieving the powder, adding a filler, performing uniform mixing, wetting a mixture with alcohol to obtain soft material, granulating the soft material, drying granules at 70 DEG C to obtain dry granules, adding a lubricant, and performing mixing and tableting to obtain the health food. The health food has good effect in terms of appearance, disintegration, hardness and tablet weight difference.
Description
Technical field
The present invention relates to a kind of preparation technology field of health food, specifically refer to a kind of preparation method of health food.
Background technology
Along with the aggravation of socioeconomic development and aged tendency of population trend, current medical model there occurs change gradually, and people develop into the present active state not having disease diseases prevention from ill passive state of curing the desease; In addition, the Diet concept also forward health product conversion of people, increasing substantially of medical expense, makes people more healthy, and the idea of Chinese medicine preventing diseases instead for the treatment of diseases receives the attention of more and more people.Therefore, to develop with the Chinese medicine of integration of edible and medicinal herbs be raw material, and health food has wide application space.
According to the raw marrow of Chinese medicine kidney, the brain being the reservoir of the marrow, kidney hides intelligence, kidney is not raw then can not expire, and the kidney being the origin of congenital constitution, Source of life scheduling theory, therefore research and development to establish with the kidney invigorating key medicine Radix Morindae Officinalis and Herba Epimedii as monarch drug, are equipped with the pure Chinese prescription health food of Fructus Lycii and Rhizoma Dioscoreae.
Summary of the invention
The object of the invention is to: the preparation method that a kind of health food is provided.
The present invention is achieved through the following technical solutions: a kind of preparation method of health food, comprises the following steps:
Step one, prepare Herba Epimedii dry extract A;
Step 2, take Rhizoma Dioscoreae powder, cross 60 mesh sieves, for subsequent use;
Step 3, get Radix Morindae Officinalis and Fructus Lycii, add 8 times amount distilled water, 100 DEG C are extracted 2h, then add 3 times amount distilled water, 100 DEG C are extracted 1h, extract 2 times, filter, merging filtrate after extracting, concentrated, add edible ethanol, sealing and standing, obtain Radix Morindae Officinalis and Fructus Lycii extractum;
Step 4, by Rhizoma Dioscoreae powder and step 3) Radix Morindae Officinalis that obtains and Fructus Lycii extractum mix, vacuum drying, obtains mixing dry extract B;
Step 5, by the Herba Epimedii dry extract A obtained in step one and step 4) the Herba Epimedii dry extract B that obtains mix, powder made by use pulverizer, sieves, add filler, mixing, with ethanol wet, make soft material, granulate, in 70 DEG C of oven dry, obtain dried particles, add lubricant, mixing, tabletting, to obtain final product.
Further, in order to better realize the present invention, also comprise following technical characteristic, the preparation process preparing Herba Epimedii dry extract A in described step one is: get epimedium herb, be placed in round-bottomed flask, adds 80% edible ethanol of 13 times amount, reflux, extract, 1h after immersion 0.5h, extract 2 times, filter, merging filtrate, carry out reclaim under reduced pressure, obtain Herba Epimedii extract concentrated solution, in 60 DEG C of vacuum dryings, to obtain final product.
Further, in order to better realize the present invention, also comprise following technical characteristic, in merging filtrate, filtrate is concentrated into 720ml in described step 3, adding 95% edible ethanol to alcohol precipitation concentration is 90%, then sealing and standing 24h, and incline supernatant, be recycled to without alcohol taste, namely obtain Radix Morindae Officinalis and Fructus Lycii mixing extractum.
Further, in order to better realize the present invention, also comprising following technical characteristic, in described step 5, Herba Epimedii dry extract A and Rhizoma Dioscoreae powder dry extract B being mixed, and after pulverizing with pulverizer, adopt 100 mesh sieve.
Low further, in order to better realize the present invention, also comprising following technical characteristic, in described step 5, Herba Epimedii dry extract A and Rhizoma Dioscoreae powder dry extract B being mixed, and after pulverizing with pulverizer, adopt 100 mesh sieve.
Further, in order to better realize the present invention, also comprise following technical characteristic, the filler added after sieving in described step 5 is microcrystalline Cellulose.
Further, in order to better realize the present invention, also comprising following technical characteristic, in described step 5, adopting 90% ethanol wet.
Further, in order to better realize the present invention, also comprise following technical characteristic, granulating in described step 5 is adopted 20 eye mesh screens to granulate.
Further, in order to better realize the present invention, also comprise following technical characteristic, after obtaining dried particles in described step 5, the lubricant added is magnesium stearate.
The present invention compared with prior art, has the following advantages and beneficial effect:
Preparation technology of the present invention is relative to prior art, and prepared health caring food tablet all has good effect in outward appearance, disintegration, hardness and tablet weight variation, and cost is low, and economic benefit is good.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited thereto.
Experimental section
Prescription forms
1 prescription composition
Herba Epimedii, Radix Morindae Officinalis, Fructus Lycii, Rhizoma Dioscoreae.
2 method for makings
2.1 Med Mat Appreciation
Herba Epimedii, Radix Morindae Officinalis, Rhizoma Dioscoreae, Fructus Lycii: pharmaceutcal corporation, Ltd is write in Guangzhou, through Chinese medicine institute of Traditional Chinese Medicine University Of Guangzhou Lin Li researcher qualification, Herba Epimedii is the dry aerial parts for berberine section plant Herba Epimedii EpimediumbrevicornumMaxim; Radix Morindae Officinalis is the dry meat root of Maguireothamnus speciosus Radix Morindae Officinalis MorindaofficinalisHow; Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum LyciumbarbarumL.; Rhizoma Dioscoreae is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae DioscoreaoppositaThunb..
The preparation of 2.2 medicines
2.2.1 epimedium herb is got in the preparation of Herba Epimedii dry extract, be placed in round-bottomed flask, add 80% edible ethanol of 13 times amount, reflux, extract, 1h after immersion 0.5h, extracts 2 times at every turn, filter, merging filtrate, merge extractive liquid, is evaporated to paste, put 60 DEG C of reduced vacuum dryings, obtain Herba Epimedii dry extract.
2.2.2 the dry extract preparation of Radix Morindae Officinalis, Fructus Lycii and Rhizoma Dioscoreae is got recipe quantity Rhizoma Dioscoreae and is pulverized, and crosses 60 mesh sieves, for subsequent use.Get Radix Morindae Officinalis and Fructus Lycii, the distilled water of first time use 8 times amount, 100 DEG C are extracted 2h, then add the distilled water of 3 times amount, and 100 DEG C are extracted 1h, extract 2 times.Filter after extracting, merging filtrate, be concentrated into 720mL, edible ethanol to the alcohol precipitation concentration adding 95% is 90%, then sealing and standing 24h, incline supernatant, be recycled to without alcohol taste, obtain Radix Morindae Officinalis and Fructus Lycii mixed sediment, add Rhizoma Dioscoreae powder and precipitate mixes, be placed in 60 DEG C of vacuum dryings, obtain mixing dry extract.
2.2.3 2 kinds of dry extracts that " 2.2.1 " item and " 2.2.2 " item obtain are merged, make powder with pulverizer, cross 100 mesh sieves, obtain medicine powder.
2.3 Study on Forming
2.3.1 the selection of adjuvant, tablet is made up of medicine and adjuvant two parts.Adjuvant is the general name of all materials except principal agent in tablet, also known as excipient, is non-therapeutic material.The adjuvant of tablet generally comprises absorbent, diluent, wetting agent, adhesive, disintegrating agent and lubricant etc.In research, to guarantee that tablet has for the purpose of good hardness, disintegration time and hydroscopicity, screening is applicable to the accessory formula of film-making.
2.3.1.1 the selection of filler, domestic comparatively conventional filler has soluble starch, Icing Sugar, dextrin, calcium sulfate, lactose etc. at present.Though lactose no hygroscopicity, there is good compressibility, do not affect the stripping of medicine, smaller on the assay impact of principal agent, but price is more expensive.And microcrystalline Cellulose is dissolved in hot water, hygroscopicity is little, moderate, and is " dilution-bonding-disintegrate " multi-functional excipient, therefore selects microcrystalline Cellulose as filler.
2.3.1.2 the selection of wetting agent, containing a large amount of sugar in this prescription component, if select water easily to cause as wetting agent difficulty of granulating because cohering.If select ethanol can overcome the granulation difficulty caused because medicine water solublity is comparatively large as wetting agent, and dry heated time can be shortened.Therefore select 90% ethanol as wetting agent.
2.3.1.3 the selection of lubricant, lubricant conveniently feeds in raw material and tabletting, reduce the frictional force between granule, between granule and nib, between tablet and mould and the greasing substance that adds, comprise hydrophobic lubricant as Pulvis Talci, magnesium stearate etc., soluble oil is as PEG etc., and fluidizer is as micropowder silica gel etc.Domestic conventional magnesium stearate is lubricant, and its lubrication is good, can reduce the ejection force of tablet significantly, and prevent glutinous punching effect, significantly can improve the outward appearance of tablet.The lubricant of this product selects magnesium stearate equally.
2.3.2 the selection of coating material, because Chinese medicinal tablet has stronger hygroscopicity usually, avoids by coating, ensures the drug effect of tablet in the long period.Aqueous coatings can avoid the volatilization of organic solvent, makes the safety raising of production process, production cost reduction, is more conducive to environmental conservation; Meanwhile, the gelling temp needed for coating process is lower, and to effective ingredient, influence factor is less, has ingredient adaptability widely.Based on above-mentioned advantage, increasing pharmaceutical factory has turned to the thin film coating system of water-soluble.Water-soluble film coating material conventional at present comprises hydroxypropyl emthylcellulose (HPMC), hydroxypropyl cellulose (HPC), Polyethylene Glycol (PEG), polyvinylpyrrolidone (PVP) etc.This tablet also can use HPMC as coating material.
2.3.3 the determination of supplementary product consumption
2.3.3.1 instrument and reagent TDP-5 single punch tablet machine, manufacturer: Shanghai Tianfan Pharmaceutical Machinery Factory; XT220A ten thousand/balance, manufacturer: Precisa company; YPJ-200A type tablet hardness tester, manufacturer: Shanghai Huanghai Sea medicine inspection instrument company; ZB-2D type Intelligent disintegration tester, manufacturer: Huankai Microbes Tech Co., Ltd., Guangdong; Microcrystalline Cellulose; Magnesium stearate; Brain recalls source medicated powder: self-control, lot number 20100413,20100510,20100518.
2.3.3.2 method and result adopt the method for orthogonal test, and choose 2 factors (microcrystalline Cellulose consumption, magnesium stearate consumption), each factor gets 3 levels as table 1, investigates the factor affecting tablet moulding process.L9 (34) design table is selected to test.Often group is recalled source extractum with 10g brain and is entered corresponding adjuvant, and mixing, sprays 90% appropriate edible ethanol soft material, wet granulation, then put dry 120min in people's 70 DEG C of baking ovens.After taking-up, granule is crossed 20 mesh sieves, granulate, add magnesium stearate mixing, utilize tablet machine to carry out film-making.As table 1:
With the outward appearance of tablet, hardness, disintegration, mass discrepancy for evaluation index, the Forming Quality of comprehensive scoring method to the tablet by design formula preparation is adopted to carry out overall merit.Tablet appearance observes its integrity, smoothness, color and luster, color fiber crops speckle abnormal phenomenon, complete bright and clean, color equal, colourless numb speckle deformity 4 points; Complete bright and clean, color is equal, even coloured numb speckle deformity 3 points; Complete bright and clean, color is equal, coloured numb speckle deformity 2 points; Complete bright and clean, uneven 1 point of color; Imperfect bright and clean 0 point.Tablet hardness (kg) adopts former numerical value to be obatained score.Disintegration (min) adopts 100 times of former numerical value inverse for obatained score.Mass discrepancy adopts 10 times of the heavy coefficient of variation (%) the percent inverse of sheet to be obatained score.When carrying out comprehensive grading with the maximum of each index for reference, data are normalized, then provide different weights.The weight coefficient of tablet hardness and disintegration is set to 0.3.Wherein comprehensive grading Y=0.2X1 × 100/4+0.3X2 × 100/5+0.3X3 × 100/5.6+0.2X4 × 100/23.5.
The higher expression mouldability of each index appraisal result is better.The best prescription meeting tablet Forming Quality and require is filtered out by appraisal result.
Observe and often organize the outward appearance that brain recalls source sheet, measure tablet hardness with tablet hardness tester, use disintegration tester to measure the disintegration of tablet, measure tablet weight variation with analytical balance, record indices result, calculates comprehensive grading.
Variance analysis is carried out to test data as shown in table 2.Application comprehensive scoring method, the test data of testing 2 factors determined is analyzed, the data display of gained: affect in 2 factors of tablet molding, microcrystalline Cellulose and magnesium stearate there are no significant impact, in conjunction with the economic factor of producing and appraisal result, show that the optimum process condition that brain recalls source sheet moulding process is A
1b
3, namely brain recalls source extractum powder: microcrystalline Cellulose: magnesium stearate=10:0.8:0.3, and comprehensive grading is 84.01.Now the consumption of microcrystalline Cellulose is less, meets economic benefit, and now tablet all can reach good effect in outward appearance, disintegration, hardness and tablet weight variation etc., determines that these process conditions are optimised process, as following table 2.
Concrete preparation technology: get epimedium herb, be placed in round-bottomed flask, add 80% edible ethanol of 13 times amount, reflux, extract, 1h after immersion 0.5h, extracts 2 times at every turn, filter, merging filtrate, carries out reclaim under reduced pressure, obtains Herba Epimedii extract concentrated solution, in 60 DEG C of vacuum dryings, obtain Herba Epimedii dry extract A for subsequent use.Get recipe quantity Rhizoma Dioscoreae to pulverize, cross 60 mesh sieves, for subsequent use.Get Radix Morindae Officinalis and Fructus Lycii, the distilled water of first time use 8 times amount, 100 DEG C are extracted 2h, add 3 times again and measure distilled water, 100 DEG C are extracted 1h, extract 2 times, filter after extracting, merging filtrate, is concentrated into 720mL, edible ethanol to the alcohol precipitation concentration adding 95% is 90%, then sealing and standing 24h, and incline supernatant, be recycled to without alcohol taste, obtain Radix Morindae Officinalis and Fructus Lycii mixing extractum, add Rhizoma Dioscoreae powder and mix extractum and mix, in 60 DEG C of vacuum dryings, obtain mixing dry extract B for subsequent use.A and B is mixed, uses pulverizer to make powder, cross 100 mesh sieves, add the amount of microcrystalline Cellulose 8% as adjuvant, mixing, with appropriate edible ethanol as wetting agent, makes soft material, granulate with 20 eye mesh screens, in 70 DEG C of oven dry, obtain dried particles, add the amount of magnesium stearate 3% as lubricant, mixing, tabletting.Obtain brain and recall source sheet.
4 quality inspections
4.1 character this product are blue or green brown disc-shaped tablet, smooth in appearance, cleaning.
4.2 quality examination 4.2.1 sample thiefs disintegration 6, recording sample disintegration is 26min, more than 60min, meets pharmacopoeial requirements.
4.2.2 mass discrepancy is got brain and is recalled 20, source sheet sample, accurately weighed gross mass, be averaging heavy after, distinguish the quality of weighed every sheet again, every tablet quality compares with average sheet heavy phase, specifies according in table 3, exceed tablet weight variation degree must not obtain more than 2, and 1 times of 1 overrun must not be had.
Designation card weighs or average sheet heavy amount diversity factor: below 0.3g ± 7.5%, 0.3g and more than 0.3g ± 5%
Table 3 tablet weight variation limit inspection record
The above is only preferred embodiment of the present invention, and not do any pro forma restriction to the present invention, every any simple modification, equivalent variations done above embodiment according to technical spirit of the present invention, all falls within protection scope of the present invention.
Claims (8)
1. a preparation method for health food, is characterized in that, comprises the following steps:
Step one, prepare Herba Epimedii dry extract A;
Step 2, take Rhizoma Dioscoreae powder, cross 60 mesh sieves, for subsequent use;
Step 3, get Radix Morindae Officinalis and Fructus Lycii, add 8 times amount distilled water, 100 DEG C are extracted 2h, then add 3 times amount distilled water, 100 DEG C are extracted 1h, extract 2 times, filter, merging filtrate after extracting, concentrated, add edible ethanol, sealing and standing, obtain Radix Morindae Officinalis and Fructus Lycii extractum;
Step 4, Radix Morindae Officinalis Rhizoma Dioscoreae powder and step 3) obtained and Fructus Lycii extractum mix, vacuum drying, obtain mixing dry extract B;
Step 5, by step one obtain Herba Epimedii dry extract A and step 4) obtain Herba Epimedii dry extract B mix, use pulverizer make powder, sieve, add filler, mixing, with ethanol wet, make soft material, granulate, in 70 DEG C of oven dry, obtain dried particles, add lubricant, mixing, tabletting, to obtain final product.
2. the preparation method of a kind of health food according to claim 1, it is characterized in that: the preparation process that described step one prepares Herba Epimedii dry extract A is: get epimedium herb, be placed in round-bottomed flask, add 80% edible ethanol of 13 times amount, reflux, extract, 1h after immersion 0.5h, extract 2 times, filter, merging filtrate, carry out reclaim under reduced pressure, obtain Herba Epimedii extract concentrated solution, in 60 DEG C of vacuum dryings, to obtain final product.
3. the preparation method of a kind of health food according to claim 1, it is characterized in that: in described step 3, in merging filtrate, filtrate is concentrated into 720ml, adding 95% edible ethanol to alcohol precipitation concentration is 90%, then sealing and standing 24h, incline supernatant, be recycled to without alcohol taste, namely obtain Radix Morindae Officinalis and Fructus Lycii mixing extractum.
4. the preparation method of a kind of health food according to claim 3, is characterized in that: mixed by Herba Epimedii dry extract A and Rhizoma Dioscoreae powder dry extract B in described step 5, and after pulverizing with pulverizer, adopts 100 mesh sieve.
5. the preparation method of a kind of health food according to claim 4, is characterized in that: the filler added after sieving in described step 5 is microcrystalline Cellulose.
6. the preparation method of a kind of health food according to claim 5, is characterized in that: adopt 90% ethanol wet in described step 5.
7. the preparation method of a kind of health food according to claim 6, is characterized in that: granulating in described step 5 is adopted 20 eye mesh screens to granulate.
8. the preparation method of a kind of health food according to claim 7, it is characterized in that: after obtaining dried particles in described step 5, the lubricant added is magnesium stearate.
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| CN201510489486.4A CN105168742A (en) | 2015-08-11 | 2015-08-11 | Making method of health food |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109865047A (en) * | 2017-12-04 | 2019-06-11 | 山东睿鹰先锋制药有限公司 | A kind of tonifying kidney and strengthening yang composition |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102972753A (en) * | 2012-08-21 | 2013-03-20 | 苏州谷力生物科技有限公司 | Health product having functions of yang strengthening and kidney invigorating |
-
2015
- 2015-08-11 CN CN201510489486.4A patent/CN105168742A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102972753A (en) * | 2012-08-21 | 2013-03-20 | 苏州谷力生物科技有限公司 | Health product having functions of yang strengthening and kidney invigorating |
Non-Patent Citations (2)
| Title |
|---|
| 周改莲 等: "保健食品脑忆源片的制备工艺研究", 《食品科技》 * |
| 周改莲 等: "复方脑忆源片在Caco-2 细胞模型上的转运研究", 《第三届中国中药商品学术年会暨首届中药葛根国际产业发展研讨会论文集》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109865047A (en) * | 2017-12-04 | 2019-06-11 | 山东睿鹰先锋制药有限公司 | A kind of tonifying kidney and strengthening yang composition |
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Application publication date: 20151223 |