CN101129642A - Method of preparing concentrated pill of six ingredients with rehmannia - Google Patents
Method of preparing concentrated pill of six ingredients with rehmannia Download PDFInfo
- Publication number
- CN101129642A CN101129642A CNA200710092432XA CN200710092432A CN101129642A CN 101129642 A CN101129642 A CN 101129642A CN A200710092432X A CNA200710092432X A CN A200710092432XA CN 200710092432 A CN200710092432 A CN 200710092432A CN 101129642 A CN101129642 A CN 101129642A
- Authority
- CN
- China
- Prior art keywords
- drying
- pill
- temperature
- ball
- ingredients
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a making method of concentrated Bolus of Six Drugs Including Rehmannia, which comprises the following steps: fetching prepared rehmannia root, Cornaceae, moutan bark, Dioscorea japonica, poria cocos wolf and Alismatales as raw materials; extracting paeonol from bark of peony root; adding dregs of a decoction, Cornaceae, prepared rehmannia root, poria cocos wolf and Alismataceae into water to boil; condensing filtrate into plaster; grinding Dioscorea japonica and residual Cornaceae powder into flour; sieving; blending evenly; blending the plaster, flour and paeonol evenly; pelletizing; drying; polishing; obtaining the plaster with relative density at 1. 38-1. 40/75 deg. c; controlling the dried pill weight at 0. 425g-0. 445g/pill and diameter at 8. 5-9. 2mm/pill; adding alcohol or disintegration agent to modify the drying technique. The invention converses 3 pills as norm as original 3g drug to satisfy the request of inner quality and appearance, which reduces the dosage for patient with convenient intake.
Description
[technical field]
The present invention relates to the preparation method of a kind of Chinese medicinal preparation method, particularly a kind of concentrated pill of six ingredients with rehmannia.
[background technology]
LIUWEI DIHUANG WAN is a kind of functions of nourishing yin and invigorating kidney that has, and is used for damage of kidney-YIN, dizziness and tinnitus, soreness of the waist and knees, osteopyrexia and fever, night sweat seminal emission, traditional Chinese patent medicine of the treatment of quenching one's thirst.The technology of prior art for preparing LIUWEI DIHUANG WAN is: get Radix Rehmanniae Preparata, Fructus Corni (system), Cortex Moutan, Rhizoma Dioscoreae, Poria and Rhizoma Alismatis Six-element medical material, Cortex Moutan is extracted paeonol; Medicinal residues and Fructus Corni (part), Radix Rehmanniae Preparata, Poria and Rhizoma Alismatis decoct with water secondary, filtrate are concentrated into relative density again and are 1.35～1.40 thick paste; Then Rhizoma Dioscoreae and residue powder of Fructus Corni are broken into fine powder, sieve mixing; Again with above thick paste, fine powder, paeonol, auxiliary materials and mixing, through pill, drying, polishing makes the concentrated pill that per 8 balls are equivalent to crude drug 3g.This medicine is because former pill particle diameter is little, and it is more to take quantity, makes the patient take medicine and not only bothers but also occur error easily, so that affect the treatment.The present invention makes 8 balls into 3 balls, and ball directly increases, and ball heavily increases, and disintegrate becomes the qualified key issue of product.
[summary of the invention]
The present invention aims to provide a kind of preparation method of concentrated pill of six ingredients with rehmannia of big pill, and this method is heavy by the dried ball of control, ball footpath, concentrated solution relative density, adds ethanol or disintegrating agent during the system soft material, and improves drying process, thereby solved a disintegrate difficult problem.
For realizing above goal of the invention, the invention discloses a kind of preparation method of concentrated pill of six ingredients with rehmannia, comprising: get Radix Rehmanniae Preparata, Fructus Corni (system), Cortex Moutan, Rhizoma Dioscoreae, Poria and Rhizoma Alismatis Six-element medical material, Cortex Moutan is extracted paeonol; Medicinal residues and Fructus Corni (part), Radix Rehmanniae Preparata, Poria and Rhizoma Alismatis decoct with water secondary, after filtrate is concentrated into thick paste; Rhizoma Dioscoreae and residue powder of Fructus Corni are broken into fine powder, sieve mixing; With above thick paste, fine powder, paeonol, auxiliary materials and mixing, make soft material again, through pill, drying, polishing is characterized in that: the relative density of the dense thick paste of described filtrate is at 1.38-1.40/75 ℃, the heavy 0.425g of dried ball～0.445g/ ball, dried ball footpath 8.5～9.2mm/ ball.
Adding accounts for soft material weight 1-2% in the described system soft material process, concentration is the ethanol of 85-95% or accounts for one of following disintegrating agent adjuvant of soft material weight 3-10%: Sodium Hydroxymethyl Stalcs CMS-Na, low-substituted hydroxypropyl cellulose L-HPC, crospolyvinylpyrrolidone PVPP.
Described drying can adopt baking oven and vibration drying, earlier shelf is gone in the heated-air circulation oven under 55～75 ℃ of temperature dry 16-20 hour; And then vacuum vibration drying twice, the vapour pressure of vibration drying is 0.3-0.5Mpa for the first time, temperature is 90-95 ℃; The vapour pressure of vibration drying is 0.28-0.33Mpa for the second time, and temperature is 80-85 ℃.
Described drying also can adopt microwave drying and oven drying, at first with the pill that makes, goes into microwave exsiccator inner drying, and frequency is 9.2～10.5Hz, and power is 7.5～8.5Kw, and transfer rate is 0.7 meter/minute, and the length of conveyer belt is 12 meters; And then send in the heated-air circulation oven under 65～75 ℃ of temperature dry 16-24 hour.
The present invention is compared with prior art: 1. by control concentrated solution relative density between 1.38～1.40/75 ℃, can overcome because of relative density is low, the extractum amount is too much, the soft material humidity that causes is excessive, too soft, medicine does not become ball-shaped after the molding; Because soft material is too soft, cutting knife can't cut soft material and causes pill method of double differences shortcoming less than normal; Also can avoid because of the relative density height causes external crack dark, or not become ball-shaped, the underproof problem of outward appearance.
Add ethanol when 2. making soft material, can make the reduced viscosity of soft material, after the ethanol volatilization, capillary permeability increases, and is beneficial to the moisture turnover.When pill during in drying, be easy to moisture and ooze out, dry easily; When measuring disintegrate simultaneously, be easy to moisture penetration, disintegrate easily.
Add Sodium Hydroxymethyl Stalcs CMS-Na, meet water after, inflatable 200～300 times of volume because own vol enlarges markedly, makes the cohesive force of pill disintegrate and collapse diffusing.
3. drying process of the present invention is suitable for the dry requirement of bolus type, has solved prolongation drying time of prior art system bolus type and has produced molten underproof problem of diffusing time again because of improving baking temperature.Wherein:
Adopt the dry and vibration drying (band vacuum) of heated-air circulation oven, can guarantee that pill is in time dry, shorten dissolve scattered time limit.After pill of the present invention was made and, because volume is relatively large, weight was heavier, if use the heated-air circulation oven drying separately, temperature can not be too high, and drying time is long, and because of heated-air circulation oven be normal pressure static state in dry, the molten after drying diffusing time of pill is long; If directly use vibration drying, pill is many because of itself containing extractum, and weight is big, and pill can be because of the deliquescing of being heated, and vibration back easy deformation causes the pill deformity.Therefore, the present invention's heated-air circulation oven drying makes a pill dehydration part, and surface strength increases, reuse vibration drying secondary, because vibration drying is a vacuum drying, temperature is relatively low, and drying is fast again, has both improved production efficiency, and dissolve scattered time limit shortens simultaneously.
Adopt microwave drying and heated-air circulation oven drying,, effectively guaranteed the water content requirement of pill, guarantee that simultaneously pill is in time dry, reduce dissolve scattered time limit by the parameter of controlled microwave.The principle of microwave drying is the hydrone of pill inside, under the microwave high-frequency effect of electric field, do strenuous exercise and produce heat energy, thereby reach exsiccant purpose, simultaneously because of hydrone huge strong motion under high-frequency electric field, changed internal structure, produce a large amount of capillary channels, pill is loose than heated-air circulation oven.The exsiccant thickness of moisture, pill of drying effect and pill inside, the length of quantity, transfer rate and conveyer belt of opening microwave tube are relevant.Through microwave drying once after because moisture reduces, pill moisture is about 10%, if continue use microwave drying, the hydrone minimizing in the pill, drying effect is bad.Therefore the present invention utilizes when pill itself has certain temperature behind the microwave primary drying, in time goes in the heated-air circulation oven dried like this better effects if.
The present invention improves through the research to prior art and makes the specification that per 3 balls are equivalent to crude drug in whole 3 grams in a word, and not only the inherent quality of medicine and outward appearance all satisfy the requirement of standard code, and patient's dose reduces taking convenience.
[specific embodiment]
The preparation method of concentrated pill of six ingredients with rehmannia of the present invention is carried out the pre-treatment of crude drug by standard, batching, powder process and extraction etc.The filtrate of extracting is concentrated into relative density at 1.38-1.40/75 ℃,, selects suitable drying process through adding ethanol or disintegrating agent, finally obtaining moisture is 5～8%, dissolve scattered time limit 55～120 minutes, the heavy 0.425g of dried ball～0.445g/ ball, the pill of dried ball footpath 8.5～9.2mm/ ball.
According to " the LIUWEI DIHUANG WAN quality standard in the Chinese pharmacopoeia, to go into dose constant though square Chinese crude drug is beaten powder, but in leaching process, difference between every batch of medical material can cause the difference of every batch of thick paste amount, and then cause finished product to criticize a ball certain difference heavily being arranged, directly be controlled in the above scope so this patent heavily reaches ball with ball.
In pill making craft, added ethanol during the system soft material, to be easy to drying, reduce dissolve scattered time limit.Wherein ethanol accounts for soft material weight 1-2%, and concentration is 85-95%;
The system soft material can also add the Sodium Hydroxymethyl Stalcs CMS-Na that accounts for soft material weight 3-10%, a kind of as disintegrating agent among low-substituted hydroxypropyl cellulose L-HPC or the crospolyvinylpyrrolidone PVPP in the technology of the present invention.
When the preparation soft material, with fine powder, extractum, paeonol combined amount, adding concentration is 93～95% ethanol, addition is 1.2～1.5% of fine powder, extractum, a paeonol total amount, can make the reduced viscosity of soft material like this, after the ethanol volatilization, capillary permeability increases, and is beneficial to the moisture turnover.When pill during in drying, be easy to moisture and ooze out, dry easily; When measuring disintegrate simultaneously, be easy to moisture penetration, disintegrate easily.
When the preparation soft material, can add Sodium Hydroxymethyl Stalcs CMS-Na, consumption is 3-7%.After meeting water, inflatable 200～300 times of volume because own vol enlarges markedly, makes the cohesive force of pill disintegrate and collapse diffusing.The CMS-Na consumption is can obviously accelerate disintegrate at 3%～7% o'clock.1%～2% o'clock not obvious to the influence of disintegration of tablet; 8%～10% has postponed disintegrate on the contrary.
When the preparation soft material, also can add low-substituted hydroxypropyl cellulose L-HPC, this disintegrating agent adjuvant expands, and consumption is 3-10%, if consumption increases to more than 20%, can prolong its disintegration.
When the preparation soft material, also can add crospolyvinylpyrrolidone PVPP, its consumption is 3-10%, simmer down to 2%.Consumption is that the dissolve scattered time limit below 5% is 80 minutes, and consumption is that 10% dissolve scattered time limit is 40 minutes, and consumption is that the dissolve scattered time limit more than 20% is 35 minutes, so the employing consumption is 3-10%.
Described drying is baking oven and vibration drying, at first with pill airing 4 hours on shelf, and airing pill thickness 3.5-4.0cm, shelf is gone in the heated-air circulation oven then, under 55～75 ℃ of temperature dry 16～20 hours; And then vibration drying twice, the vapour pressure of vibration drying is 0.3Mpa for the first time, temperature is 95 ℃; The vapour pressure of vibration drying is 0.28Mpa for the second time, and temperature is 85 ℃.Obtaining moisture is 5～8%, 90～120 minutes pill of dissolve scattered time limit.
Described drying is microwave and oven drying, microwave drying is the pill that will make, go into tunnel type micro wave exsiccator inner drying, it is 0.7～1.0cm that pill spreads thickness, and preheat temperature is 50～55 ℃, baking temperature is 70～80 ℃, transfer rate is 0.7 meter/minute, and it is 9～11 that microwave tube is opened number, and frequency is 9.2～10.5Hz, power is 7.5～8.5Kw, and the length of conveyer belt is 12 meters; Obtaining moisture is 10%, and dissolve scattered time limit is 47 minutes a pill.And then send in the heated-air circulation oven, drying is 16～24 hours under 65～75 ℃ of temperature, and obtaining moisture is 6.5～7.5%, and dissolve scattered time limit is 68～80 minutes a pill.
Can better understand the present invention by following examples, following this example only is used to the present invention is described and to the present invention without limits.
Embodiment 1
Prescription: Radix Rehmanniae Preparata 320g, Fructus Corni (system) 160g, Paeonia suffruticosa 120g, Rhizoma Dioscoreae 160g, Poria 120g, Rhizoma Alismatis 120g.
Preparation technology is: by the nine flavor medical materials of Radix Rehmanniae Preparata, Fructus Corni, Paeonia suffruticosa, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis etc. in the prescription side of measuring, Cortex Moutan is extracted paeonol; Medicinal residues and Fructus Corni 27g, Radix Rehmanniae Preparata, Poria and Rhizoma Alismatis decoct with water secondary, and each two hours, filtrate was concentrated into the thick paste that density is 1.32-1.40, and Rhizoma Dioscoreae and residue powder of Fructus Corni are broken into fine powder, sieve mixing; Again with above thick paste, fine powder, paeonol, auxiliary materials and mixing, 93% ethanol that adds is made soft material, add alcoholic acid amount and be 1.2% of fine powder, extractum, paeonol total amount, wet-pill making, average ball heavily is the 0.477g/ ball, adopts baking oven and vibration drying drying, polishing, get average ball footpath 8.5mm/ ball, average ball heavily is product 1000 balls of 0.425g/ ball.In the present embodiment, before the drying at first with pill airing 4 hours on shelf, airing pill thickness 3.5-4.0cm, shelf is gone in the heated-air circulation oven then, under 55～75 ℃ of temperature dry 16～18 hours; And then vibration drying twice, the vapour pressure of vibration drying is 0.3Mpa for the first time, temperature is 95 ℃; The vapour pressure of vibration drying is 0.28Mpa for the second time, and temperature is 85 ℃.
Embodiment 2
Prescription: Radix Rehmanniae Preparata 320g, Fructus Corni (system) 160g, Paeonia suffruticosa 120g, Rhizoma Dioscoreae 160g, Poria 120g, Rhizoma Alismatis 120g.
Preparation technology is: by the nine flavor medical materials of Radix Rehmanniae Preparata, Fructus Corni, Paeonia suffruticosa, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis etc. in the prescription side of measuring, Cortex Moutan is extracted paeonol; Medicinal residues and Fructus Corni 27g, Radix Rehmanniae Preparata, Poria and Rhizoma Alismatis decoct with water secondary, and each two hours, filtrate was concentrated into the thick paste that density is 1.32-1.40, and Rhizoma Dioscoreae and residue powder of Fructus Corni are broken into fine powder, sieve mixing; Again with above thick paste, fine powder, paeonol, auxiliary materials and mixing, 95% ethanol that adds is made soft material, add alcoholic acid amount and be 1.5% of fine powder, extractum, paeonol total amount, wet-pill making, average ball heavily is the 0.483g/ ball, adopts microwave and oven drying, polishing, get average ball footpath 9.2mm/ ball, average ball heavily is product 1000 balls of 0.445g/ ball.In the present embodiment, it is 0.7～1.0cm that the microwave drying pill spreads thickness, and preheat temperature is 50～55 ℃, and baking temperature is 70～80 ℃, and transfer rate is 0.7 meter/minute; Send in the heated-air circulation oven, drying is 16～24 hours under 65～75 ℃ of temperature.
Embodiment 3
Prescription: Radix Rehmanniae Preparata 320g, Fructus Corni (system) 160g, Paeonia suffruticosa 120g, Rhizoma Dioscoreae 160g, Poria 120g, Rhizoma Alismatis 120g.
By the nine flavor medical materials of Radix Rehmanniae Preparata, Fructus Corni, Paeonia suffruticosa, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis etc. in the prescription side of measuring, Cortex Moutan is extracted paeonol; Medicinal residues and Fructus Corni 27g, Radix Rehmanniae Preparata, Poria and Rhizoma Alismatis decoct with water secondary, and each two hours, filtrate was concentrated into the thick paste that density is 1.32-1.40, and Rhizoma Dioscoreae and residue powder of Fructus Corni are broken into fine powder, sieve mixing; Again with above thick paste, fine powder, paeonol, auxiliary materials and mixing, 3% Sodium Hydroxymethyl Stalcs of adding is made soft material, and the average ball of wet-pill making heavily is the 0.480g/ grain, adopt microwave and oven drying, polishing gets average ball footpath 8.8mm/ grain, and average ball heavily is product 1000 balls of 0.438g/ grain.In the present embodiment, it is 0.7～1.0cm that the microwave drying pill spreads thickness, and preheat temperature is 50～55 ℃, and baking temperature is 70～80 ℃; Send in the heated-air circulation oven, drying is 16～24 hours under 65～75 ℃ of temperature.
Embodiment 4
Prescription: Radix Rehmanniae Preparata 320g, Fructus Corni (system) 160g, Paeonia suffruticosa 120g, Rhizoma Dioscoreae 160g, Poria 120g, Rhizoma Alismatis 120g.
By the nine flavor medical materials of Radix Rehmanniae Preparata, Fructus Corni, Paeonia suffruticosa, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis etc. in the prescription side of measuring, Cortex Moutan is extracted paeonol; Medicinal residues and Fructus Corni 27g, Radix Rehmanniae Preparata, Poria and Rhizoma Alismatis decoct with water secondary, and each two hours, filtrate was concentrated into the thick paste that density is 1.32-1.40, and Rhizoma Dioscoreae and residue powder of Fructus Corni are broken into fine powder, sieve mixing; Again with above thick paste, fine powder, paeonol, auxiliary materials and mixing, add a certain amount of 7% Sodium Hydroxymethyl Stalcs CMC-Na and make soft material, wet-pill making, average ball heavily is the 0.479g/ ball, adopt microwave and oven drying, polishing gets average ball footpath 8.9mm/ ball, and average ball heavily is product 1000 balls of 0.435g/ ball.In the present embodiment, it is 0.7～1.0cm that the microwave drying pill spreads thickness, and preheat temperature is 50～55 ℃, and baking temperature is 70～80 ℃, and transfer rate is 0.7 meter/minute; Send in the heated-air circulation oven, drying is 16～24 hours under 65～75 ℃ of temperature.
Embodiment 5
Prescription: Radix Rehmanniae Preparata 320g, Fructus Corni (system) 160g, Paeonia suffruticosa 120g, Rhizoma Dioscoreae 160g, Poria 120g, Rhizoma Alismatis 120g.
By the nine flavor medical materials of Radix Rehmanniae Preparata, Fructus Corni, Paeonia suffruticosa, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis etc. in the prescription side of measuring, Cortex Moutan is extracted paeonol; Medicinal residues and Fructus Corni 27g, Radix Rehmanniae Preparata, Poria and Rhizoma Alismatis decoct with water secondary, and each two hours, filtrate was concentrated into the thick paste that density is 1.32-1.40, and Rhizoma Dioscoreae and residue powder of Fructus Corni are broken into fine powder, sieve mixing; With above thick paste, fine powder, paeonol, auxiliary materials and mixing, 10% low-substituted hydroxypropyl cellulose L-HPC makes soft material, wet-pill making again, average ball heavily is the 0.479g/ ball, adopts microwave and oven drying, polishing, get average ball footpath 8.7mm/ ball, average ball heavily is product 1000 balls of 0.440g/ ball.In the present embodiment, it is 0.7～1.0cm that the microwave drying pill spreads thickness, and preheat temperature is 50～55 ℃, and baking temperature is 70～80 ℃, and transfer rate is 0.7 meter/minute; Send in the heated-air circulation oven, drying is 16～24 hours under 65～75 ℃ of temperature.
Embodiment 6
Prescription: Radix Rehmanniae Preparata 2560g, Fructus Corni (system) 1280g, Paeonia suffruticosa 960g, Rhizoma Dioscoreae 1280g, Poria 960g, Rhizoma Alismatis 960g.
By the nine flavor medical materials of Radix Rehmanniae Preparata, Fructus Corni, Paeonia suffruticosa, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis etc. in the prescription side of measuring, Cortex Moutan is extracted paeonol; Medicinal residues and Fructus Corni 27g, Radix Rehmanniae Preparata, Poria and Rhizoma Alismatis decoct with water secondary, and each two hours, filtrate was concentrated into the thick paste that density is 1.32-1.40, and Rhizoma Dioscoreae and residue powder of Fructus Corni are broken into fine powder, sieve mixing; With above thick paste, fine powder, paeonol, auxiliary materials and mixing, 10% crospolyvinylpyrrolidone PVPP makes soft material, wet-pill making again, average ball heavily is the 0.481g/ ball, adopts microwave and oven drying, polishing, get average ball footpath 8.9mm/ ball, average ball heavily is product 1000 balls of 0.443g/ ball.In the present embodiment, it is 0.7～1.0cm that the microwave drying pill spreads thickness, and preheat temperature is 50～55 ℃, and baking temperature is 70～80 ℃, and transfer rate is 0.7 meter/minute; Send in the heated-air circulation oven, drying is 16～24 hours under 65～75 ℃ of temperature.
Claims (6)
1. the preparation method of a concentrated pill of six ingredients with rehmannia comprises: get Radix Rehmanniae Preparata, Fructus Corni (processed), Cortex Moutan, Rhizoma Dioscoreae, Poria and Rhizoma Alismatis Six-element medical material, Cortex Moutan is extracted paeonol; Medicinal residues and Fructus Corni, Radix Rehmanniae Preparata, Poria and Rhizoma Alismatis decoct with water secondary, after filtrate is concentrated into thick paste; Rhizoma Dioscoreae and residue powder of Fructus Corni are broken into fine powder, sieve mixing; With above thick paste, fine powder, paeonol mixing, make soft material again, pill, drying, polishing is characterized in that: the relative density of described filtrate thick paste is at 1.38-1.40/75 ℃, and dried ball weighs 0.425g～0.445g/ ball, dried ball footpath 8.59.2mm/ ball.
2. the preparation method of concentrated pill of six ingredients with rehmannia according to claim 1, add when it is characterized in that making soft material account for soft material weight 1-2%, concentration is the ethanol of 85-95% or accounts for one of following disintegrating agent adjuvant of soft material weight 3-10%: Sodium Hydroxymethyl Stalcs CMS-Na, low-substituted hydroxypropyl cellulose L-HPC, crospolyvinylpyrrolidone PVPP.
3. the preparation method of concentrated pill of six ingredients with rehmannia according to claim 1 and 2 is characterized in that described drying is baking oven and vibration drying, earlier shelf is gone in the heated-air circulation oven under 55～75 ℃ of temperature dry 16-20 hour; And then vacuum vibration drying twice, the vapour pressure of vibration drying is 0.3-0.5Mpa for the first time, temperature is 90-95 ℃; The vapour pressure of vibration drying is 0.28-0.33Mpa for the second time, and temperature is 80-85 ℃.
4. the preparation method of concentrated pill of six ingredients with rehmannia according to claim 3 is characterized in that the vapour pressure of described first time of vibration drying is 0.3Mpa, and temperature is 95 ℃; The vapour pressure of vibration drying is 0.28Mpa for the second time, and temperature is 85 ℃.
5. the preparation method of concentrated pill of six ingredients with rehmannia according to claim 1 and 2, it is characterized in that described drying is microwave drying and oven drying, at first with the pill that makes, go into microwave exsiccator inner drying, frequency is 9.2～10.5Hz, power is 7.5～8.5Kw, and transfer rate is 0.7 meter/minute, and the length of conveyer belt is 12 meters; And then send in the heated-air circulation oven under 65～75 ℃ of temperature dry 16-24 hour.
6. the preparation method of concentrated pill of six ingredients with rehmannia according to claim 5 is characterized in that it is 0.7-1.0cm that described microwave drying Chinese medicine pill spreads thickness, and preheat temperature is 50～55 ℃, and baking temperature is 70～80 ℃, and it is 9～11 that microwave tube is opened number.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200710092432XA CN100528143C (en) | 2007-07-16 | 2007-07-16 | Method of preparing concentrated pill of six ingredients with rehmannia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200710092432XA CN100528143C (en) | 2007-07-16 | 2007-07-16 | Method of preparing concentrated pill of six ingredients with rehmannia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101129642A true CN101129642A (en) | 2008-02-27 |
| CN100528143C CN100528143C (en) | 2009-08-19 |
Family
ID=39127154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB200710092432XA Active CN100528143C (en) | 2007-07-16 | 2007-07-16 | Method of preparing concentrated pill of six ingredients with rehmannia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100528143C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293897A (en) * | 2011-08-26 | 2011-12-28 | 太极集团重庆涪陵制药厂有限公司 | Preparation method of Liuweidihuang pills |
| CN102920882A (en) * | 2011-11-01 | 2013-02-13 | 九芝堂股份有限公司 | Concentrated Liuwei dihuang pill preparation method |
| CN103655727A (en) * | 2013-12-09 | 2014-03-26 | 贵州信邦制药股份有限公司 | Condensed pill prepared from ligustrum lucidum and radix astragali and capable of reinforcing healthy qi, and preparation method thereof |
| CN103933295A (en) * | 2014-04-01 | 2014-07-23 | 回音必集团安徽制药有限公司 | Six-ingredient rehmannia pill and preparation technology thereof |
-
2007
- 2007-07-16 CN CNB200710092432XA patent/CN100528143C/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293897A (en) * | 2011-08-26 | 2011-12-28 | 太极集团重庆涪陵制药厂有限公司 | Preparation method of Liuweidihuang pills |
| CN102293897B (en) * | 2011-08-26 | 2013-04-17 | 太极集团重庆涪陵制药厂有限公司 | Preparation method of Liuweidihuang pills |
| CN102920882A (en) * | 2011-11-01 | 2013-02-13 | 九芝堂股份有限公司 | Concentrated Liuwei dihuang pill preparation method |
| CN102920882B (en) * | 2011-11-01 | 2017-05-17 | 九芝堂股份有限公司 | Concentrated Liuwei dihuang pill preparation method |
| CN103655727A (en) * | 2013-12-09 | 2014-03-26 | 贵州信邦制药股份有限公司 | Condensed pill prepared from ligustrum lucidum and radix astragali and capable of reinforcing healthy qi, and preparation method thereof |
| CN103933295A (en) * | 2014-04-01 | 2014-07-23 | 回音必集团安徽制药有限公司 | Six-ingredient rehmannia pill and preparation technology thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100528143C (en) | 2009-08-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103055016B (en) | Freeze-dried fresh rehmannia for treating acne | |
| CN105853484A (en) | Preparation method of notoginseng raw powder tablet | |
| CN100528143C (en) | Method of preparing concentrated pill of six ingredients with rehmannia | |
| CN103655639A (en) | Spirulina tablet, and preparation method thereof | |
| CN105902587A (en) | Preparation method of panax quinquefolius raw powder tablets | |
| CN105125689B (en) | A kind of lavipeditum powder containing the FUKE QIANJIN PIAN dregs of a decoction and preparation method thereof | |
| CN107617036B (en) | Pill of six ingredients with rehmannia and preparation process thereof | |
| CN101428041A (en) | Cordyceps sinensis extract, preparation method and uses in preparing medicament | |
| CN103381193B (en) | A kind of Rhodiola rosea micro powder tablet and preparation method thereof | |
| CN105561275A (en) | Preparation method of cough-relieving tablet | |
| CN109091603A (en) | A kind of drug and preparation method thereof for treating canker sore | |
| CN108159334A (en) | Osteopractic | |
| CN104623344A (en) | Medicament for treating yang deficiency and spontaneous sweating and preparation method of oral pellets thereof | |
| CN101708307A (en) | Medicament for treating hyperplasia of mammary glands and preparation method thereof | |
| CN103989983A (en) | Black sesame and sophora flavescens effervescent tablet and preparation method thereof | |
| CN100551425C (en) | A kind of Chinese medicine composition composition dispersible tablets for the treatment of gastrointestinal disease and preparation method thereof | |
| CN105381201A (en) | Preparation method for traditional Chinese medicine used for diabetes | |
| CN100512871C (en) | Method for preparing coated tablets for treating cholecystitis | |
| CN101181586A (en) | Method for preparing qi-regulating pill of aucklandia | |
| CN105535052B (en) | A kind of donkey-hide gelatin Radix Panacis Quinquefolii micropowder piece and preparation method thereof | |
| CN103860705B (en) | A kind of Chinese medicine composition being used for the treatment of cyclomastopathy and its preparation method and application | |
| CN116350683B (en) | Compound Baical skullcap root film coated tablet and preparation method thereof | |
| CN100387251C (en) | Film coated tablet for bone injury and preparation process thereof | |
| CN103655727A (en) | Condensed pill prepared from ligustrum lucidum and radix astragali and capable of reinforcing healthy qi, and preparation method thereof | |
| CN110151844A (en) | A kind of tonic tablet for kidney-reinforcing and anticracking preparation process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 402260 Chongqing City, few town Jiangjin District No. 28 Ring Road Patentee after: TAIJI GROUP CHONGQING NO.2 CHINESE MEDICINE FACTORY Co.,Ltd. Address before: 402260 Chongqing City, few town Jiangjin District No. 28 Ring Road Patentee before: TAIJI Group CHONGQING SECOND TRADITIONAL CHINESE MEDICINE FACTORY |
|
| CP01 | Change in the name or title of a patent holder |