CN104547209A - Preparation method of traditional Chinese medicine composition - Google Patents
Preparation method of traditional Chinese medicine composition Download PDFInfo
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- CN104547209A CN104547209A CN201310508483.1A CN201310508483A CN104547209A CN 104547209 A CN104547209 A CN 104547209A CN 201310508483 A CN201310508483 A CN 201310508483A CN 104547209 A CN104547209 A CN 104547209A
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Abstract
The invention discloses a preparation method of a traditional Chinese medicine composition, belonging to the field of medicine preparation. The traditional Chinese medicine composition consists of the medicines such as fructus forsythiae, flos lonicerae and radix isatidis; and the medicines are extracted and concentrated into a clear paste, menthol is covered with beta-cyclodextrin and then uniformly mixed with the clear paste, and the mixture is granulated to obtain the traditional Chinese medicine composition. According to the preparation method disclosed by the invention, the menthol has a relatively high transfer rate, and the covering time is short; and the method is reasonable and feasible and is suitable for industrial production.
Description
Technical field
The invention belongs to pharmaceutical formulating art, be specifically related to the preparation method of Chinese medicine composition.
Background technology
This Chinese medicine composition be used for the treatment of influenza belong to pyretic toxicity attack lung card, be widely used in clinical, successful.The pungent cool fragrance of Mentholum, light weight is floating loose, refresh oneself, and logical upper orifices, throat, has the effect of the auxiliary property of medicine in prescription.But crystallization easily distils, former technique is spray in granule after Mentholum is dissolved in ethanol, there is the problem that Mentholum volatilization affects product quality in medicament storage process.Use beta-schardinger dextrin-by volatile matter enclose, can greatly improve volatile matter stability, reduce its loss in preparation and storage process.Conventional beta-cyclodextrin inclusion compound method has saturated aqueous solution rapid agitation, ultrasonic method, colloid milling, and wherein to have the enclose time short for colloid milling, inclusion rate advantages of higher.
Summary of the invention
The object of this invention is to provide a kind of preparation method of Chinese medicine composition.
The technical solution adopted in the present invention is:
A preparation method for Chinese medicine composition, described Chinese medicine composition is made up of the crude drug of following weight portion: Fructus Forsythiae 250-300, Flos Lonicerae 250-300, Radix Isatidis 250-300, Radix Et Rhizoma Rhei 50-60, Herba Pogostemonis 60-90, Rhizoma Dryopteris Crassirhizomatis 250-300, Radix Rhodiolae 60-90, Mentholum 5-8, Herba Ephedrae 60-90, Semen Armeniacae Amarum 60-90, Herba Houttuyniae 250-300, Radix Glycyrrhizae 60-90, Gypsum Fibrosum 250-300; Described Chinese medicine composition is made up of following steps:
(1) take Chinese crude drug according to crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, extracting in water volatile oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with ethanol extraction 2 times, extracting solution merges and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, decocting with water to boiling, adding Semen Armeniacae Amarum, decoct 2 times, extracting solution merges filtration, and the filtrate after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, and is condensed into clear paste, add ethanol, reconciling to determining alcohol is 70%, and cold preservation is placed, and filters, reclaim ethanol to without alcohol taste, obtain clear paste for subsequent use;
(5) step (4) gained clear paste and step (3) gained alcohol extract are merged, be condensed into clear paste;
(6) beta-schardinger dextrin-is got, pour in colloid mill, add step (5) gained part clear paste and water grinding evenly, the Mentholum of dissolve with ethanol is slowly dripped again in colloid mill, step (5) the gained clear paste added and the mass ratio of Mentholum are 0.25-1:1, grinding, filter, drying, obtains Mentholum clathrate;
(7) step (6) gained Mentholum clathrate and remaining step (5) gained clear paste are mixed, then add suitable pharmaceutically acceptable adjuvant granulation;
(8) step (2) gained volatile oil is added dissolve with ethanol, spray into step (7) gained granule, conventionally make preparation.
As optimal way, the amount of the water added in described step (6) is 2-3 times of Mentholum and beta-schardinger dextrin-, and ethanol used is 70-99% ethanol, and Mentholum and beta-schardinger dextrin-mol ratio are 1:0.8-1, and milling time is 20-30 minute.
As optimal way, described Chinese medicine composition is made up of the crude drug of following weight portion:
Fructus Forsythiae 250 Flos Lonicerae 300 Radix Isatidis 250 Radix Et Rhizoma Rhei 60 Herba Pogostemonis 60
Rhizoma Dryopteris Crassirhizomatis 300 Radix Rhodiolae 60 Mentholum 8 Herba Ephedrae 60 Semen Armeniacae Amarum 90
Herba Houttuyniae 250 Radix Glycyrrhizae 90 Gypsum Fibrosum 250.
Or
Fructus Forsythiae 300 Flos Lonicerae 250 Radix Isatidis 300 Radix Et Rhizoma Rhei 50 Herba Pogostemonis 90
Rhizoma Dryopteris Crassirhizomatis 250 Radix Rhodiolae 90 Mentholum 5 Herba Ephedrae 90 Semen Armeniacae Amarum 60
Herba Houttuyniae 300 Radix Glycyrrhizae 60 Gypsum Fibrosum 300.
Or
Fructus Forsythiae 255 Flos Lonicerae 255 Radix Isatidis 255 Radix Et Rhizoma Rhei 51 Herba Pogostemonis 85
Rhizoma Dryopteris Crassirhizomatis 255 Radix Rhodiolae 85 Mentholum 7.5 Herba Ephedrae 85 Semen Armeniacae Amarum 85
Herba Houttuyniae 255 Radix Glycyrrhizae 85 Gypsum Fibrosum 255.
Described Radix Glycyrrhizae is Radix Glycyrrhizae Preparata, and Herba Ephedrae is Herba Ephedrae (processed), and described Semen Armeniacae Amarum is Semen Armeniacae Amarum (parched).
For realizing technique scheme, described medicine is made capsule, tablet, powder, oral liquid, pill, tincture, syrup, suppository, gel, spray or injection.
For enabling above-mentioned dosage form realize, the acceptable adjuvant of pharmacy need be added when preparing these dosage forms, such as: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose, Icing Sugar, dextrin etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, acetic acid chloroethene are fixed, Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods; Substrate comprises: PEG6000, PEG4000, insect wax etc. (Fan Biting " pharmacy of Chinese materia medica ", Shanghai Science Press. December the 1st edition in 1997. the adjuvant that each dosage form is recorded).
Described granule is made up of following steps:
(1) take Chinese crude drug according to crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 8-10 times amount water extraction volatile oil, carries the 4 hours time of oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with the ethanol extraction 2 times of 6-10 times amount 50-90%, each 1-3 hour, extracting solution merges and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adds 7-11 times amount soak by water to boiling, and adds Semen Armeniacae Amarum, decocts 2 times, each 0.5-2.5 hour, extracting solution merges filtration, and the filtrate after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, and being condensed into and measuring relative density 60 DEG C time is the clear paste of 1.10-1.15, add ethanol, being adjusted to determining alcohol is 70%, and cold preservation is placed, and filters, reclaim ethanol to without alcohol taste, obtain clear paste for subsequent use;
(5) step (4) gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density 60 DEG C time is the clear paste of 1.15-1.20;
(6) beta-schardinger dextrin-is got, pour in colloid mill, add step (5) gained part clear paste and water grinding evenly, then in colloid mill, slowly drip the Mentholum of 70-99% dissolve with ethanol, the water added is the 2-3 times amount of Mentholum and beta-schardinger dextrin-, step (5) the gained clear paste added and the mass ratio of Mentholum are 0.25-1:1, Mentholum and beta-schardinger dextrin-mol ratio are 1:0.8-1, and grinding 20-30 minute, filters, drying, obtains Mentholum clathrate;
(7) step (6) gained Mentholum clathrate and remaining step (5) gained clear paste are mixed, then add suitable pharmaceutically acceptable adjuvant granulation;
(8) step (2) gained volatile oil is added dissolve with ethanol, spray into step (7) gained granule, airtight, mixing, pack, to obtain final product.
In order to verify stability and the rate of transform of the Mentholum after enclose, do following experiment
Experiment one, the Mentholum rate of transform
1 experimental apparatus and reagent
PM-85 colloid mill, Tianjin Xin Pu Machinery Manufacturing Co., Ltd.; Mentholum (Anhui Feng Le essence company limited); Beta-schardinger dextrin-(Anhui Shanhe Medicinal Subsidiary Material Co., Ltd.); Ethanol (Meihekou City Fukang ethanol Co., Ltd).
2 methods and result
2.1 prepare clathrate means gets ormal weight beta-schardinger dextrin-, pours in colloid mill, adds 2-3 times of water gaging grinding evenly, the Mentholum of 95% dissolve with ethanol of slow dropping weight ratio 1:1, grinding 20-30 minute, sucking filtration, namely heated-air circulation oven 40 degree of dry 24h obtain the Mentholum after enclose.
In 2.2 clathrates, Determination of menthol measures: take clathrate 20mg, put in 15ml tool plug centrifuge tube, add dehydrated alcohol 10ml to mix, ultrasonic 10min, place after concussion 10min and spend the night, next day, centrifugal 10 minutes of 4000r/min, got supernatant for subsequent use, Determination of menthol in gas chromatographic detection clathrate, thus calculate the Mentholum rate of transform.
2.3 EXPERIMENTAL DESIGN
With the Mentholum rate of transform for index, investigate Mentholum beta-schardinger dextrin-material ratio, milling time, amount of water, on the impact of enclose effect, according to preliminary result in early stage, chooses L
9(3
4) orthogonal table experiment arrangement, orthogonal test factor level and the results are shown in Table 1, the results of analysis of variance is in table 2.
Table 1 clathrate prepares orthogonal test factor level and result
Table 2 clathrate prepares quadrature factor variance analysis
2.4 from table 1,2 results, each factor affects the order that clathrate prepares effect: A>C>B, the present invention have selected the process conditions that the Mentholum rate of transform is more than 70%, the rate of transform of super other the process conditions gone beyond the scope is too low, effect is all not so good, affects the effect of whole Chinese medicine composition; Optimum process condition is defined as A
1b
1c
1, i.e. Mentholum and beta cyclodextrin molar ratio of material example 1:0.8, milling time 20min, the times amount that adds water 2 times.
2.5 demonstration test
Get equivalent Mentholum respectively and carry out 3 batches of productions according to optimum process condition, the Mentholum rate of transform is respectively 94.18%, 92.37%, 92.01%, meansigma methods 92.85%, shows that this process repeatability is better, scientific and reasonable.
2.6 Mentholum Benexate Hydrochlorides are used for medicament composition granule Study on Preparation of the present invention
Because clathrate is pure white, as added when yellowish-brown medicament composition granule of the present invention is always mixed by former technique, affect particle appearance.Therefore adding the clathrate improving aberration with medicament composition granule mixing extractum of the present invention when investigating total mixing, dry clathrate carries out medicament composition granule wet granulation of the present invention, directly carries out wet granulation three kinds of techniques after clathrate preparation.
2.6.1 medicament composition granule mixing extractum of the present invention improves the test of Mentholum clathrate aberration
Get appropriate Mentholum respectively and carry out enclose test according to 2.4 optimum process conditions; 0.15,0.25,0.35 times amount medicament composition granule mixing of the present invention extractum is added respectively before enclose; when extractum addition is 0.25 times amount; clathrate aberration can be improved; the obtained clathrate Mentholum rate of transform is respectively 83.67%; 86.40%; 87.76%; meansigma methods is 85.94%; the rate of transform is a little less than not adding the clathrate mixing extractum and prepare; illustrate that enclose process adds extractum and only deepens clathrate color, substantially do not affect Mentholum enclose effect.
2.6.2 Mentholum clathrate heat stabilization test
Medicament composition granule wet granulation method of the present invention mixes for being dropped in wet granulator by adjuvant; binding agent soft material is made with mixing extractum; oscillating granulator is granulated; fluidised bed granulator is dry; time dry, temperature of charge controls at 60 ~ 65 DEG C, the qualified rear stopping heating (being generally 30min during large production) of moisture.Clathrate need be investigated at 60 ~ 65 DEG C of heating 30min to the impact of Determination of menthol as added clathrate when granulating.Get clathrate and be placed in 65 DEG C of baking ovens, detect respectively constant temperature 0,30, the content of 60min Mentholum, result is respectively 12.44%, 12.51%, 12.10%, and Mentholum clathrate good thermal stability under 65 DEG C of constant temperature 1h is described, can add clathrate when granulation.
2.6.3 dry clathrate wet granulation test
Get appropriate clathrate and carry out 3 batches of pilot plant tests by above-mentioned method of granulating, detect Determination of menthol in medicament composition granule of the present invention, and calculate the rate of transform of Mentholum in wet-granulation process.
3 batches of pilot plant test Mentholum rates of transform are respectively 100.1%, 100.4%, 101.2%, meansigma methods 100.5%,
After wet granulation is described, airpillow-dry does not affect Mentholum enclose effect; the method rate of transform is high, do not need additionally to consume medicament composition granule mixing extractum of the present invention, therefore adds the technique improving aberration with medicament composition granule mixing extractum of the present invention when being better than always mixing.
2.6.4 directly wet granulation test after clathrate preparation
Needing 40 degree of dry 24h after clathrate preparation, for saving man-hour, energy savings, clathrate after preparation directly can be granulated.Get respectively directly to drop in wet granulator with adjuvant after appropriate Mentholum carries out enclose according to 2.4 optimum process conditions and mix; granulate; airpillow-dry, detects Determination of menthol in medicament composition granule of the present invention, and the rate of transform after calculating Mentholum enclose in direct wet-granulation process.
Result is respectively 102.1%, 101.2%, 100.6%, meansigma methods 101.3%, and the rate of transform is suitable with dry clathrate wet granulation, but the energy of saving time, therefore after clathrate preparation, direct wet granulation technology is best applications technique.
2.6.5 demonstration test
Get 2.4Kg Mentholum respectively and carry out 3 batches of productions according to best clathrate process condition, directly carry out wet granulation, airpillow-dry, in 3 batches of medicament composition granules of the present invention, the Mentholum rate of transform is respectively 100.2%, 100.6%, 101.7%, meansigma methods 100.8%, show that after the preparation of this clathrate, directly wet granulation technology repeatability is better, scientific and reasonable.
Experiment two, study on the stability
The Chinese medicinal composition preparation of getting the Mentholum of original non-enclose is numbered 1 and 2, then the Chinese medicinal composition preparation of getting the Mentholum after enclose is numbered 3 and 4;
Table 3 ordinary temperature stability composition transfer rate
Perusal, the preparation of 1 and 2 has Mentholum crystal to separate out, and 3 and 4 do not have.
Owing to have employed technique scheme, the technological progress that the present invention obtains is:
Preparation method of the present invention, make Mentholum have the higher rate of transform, the enclose time is short, and stability, this method reasonable, is applicable to commercial production.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in further details:
Embodiment 1
Crude drug formula is as follows:
Fructus Forsythiae 250g Flos Lonicerae 300g Radix Isatidis 250g Radix Et Rhizoma Rhei 60g Herba Pogostemonis 60g
Rhizoma Dryopteris Crassirhizomatis 300g Radix Rhodiolae 60g Mentholum 8g Herba Ephedrae 60g Semen Armeniacae Amarum 90g
Herba Houttuyniae 250g Radix Glycyrrhizae 90g Gypsum Fibrosum 250g.
The preparation method of granule is as follows:
(1) take Chinese crude drug according to crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 8 times amount water extraction volatile oil, carries the 4 hours time of oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with the ethanol extraction 2 times of 6 times amount 50%, each 1 hour, extracting solution merged and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adds 7 times amount soak by water to boiling, and adds Semen Armeniacae Amarum, decocts 2 times, each 0.5 hour, extracting solution merges filtration, and the filtrate after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, and being condensed into and measuring relative density 60 DEG C time is the clear paste of 1.10, add ethanol, being adjusted to determining alcohol is 70%, and cold preservation is placed, and filters, reclaim ethanol to without alcohol taste, obtain clear paste for subsequent use;
(5) step (4) gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density 60 DEG C time is the clear paste of 1.15;
(6) beta-schardinger dextrin-is taken, pour in colloid mill, add step (5) gained part clear paste and water grinding evenly, then in colloid mill, slowly drip the Mentholum of 95% dissolve with ethanol, the water added is 2 times amount of Mentholum and beta-schardinger dextrin-, step (5) the gained clear paste added and Mentholum mass ratio are 0.25:1, Mentholum and beta-schardinger dextrin-mol ratio are 1:0.8, grind 20 minutes, sucking filtration, heated-air circulation oven 40 DEG C of dry 24h, obtain Mentholum clathrate;
(7) step (6) gained Mentholum clathrate and remaining step (5) gained clear paste are mixed, then add Icing Sugar 516.8g, dextrin 775.6g granulates;
(8) step (2) gained volatile oil is added dissolve with ethanol, spray into step (7) gained granule, airtight, mixing, pack, to obtain final product.
Embodiment 2
Crude drug formula is:
Fructus Forsythiae 255g Flos Lonicerae 255g Radix Isatidis 255g Radix Et Rhizoma Rhei 51g Herba Pogostemonis 85g
Rhizoma Dryopteris Crassirhizomatis 255g Radix Rhodiolae 85g Mentholum 7.5g Herba Ephedrae 85g Semen Armeniacae Amarum 85g
Herba Houttuyniae 255g Radix Glycyrrhizae 85g Gypsum Fibrosum 255g.
The preparation method of tablet is as follows:
(1) take Chinese crude drug according to crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 10 times amount water extraction volatile oil, carries the 4 hours time of oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with the ethanol extraction 2 times of 10 times amount 90%, each 3 hours, extracting solution merged and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adds 11 times amount soak by water to boiling, and adds Semen Armeniacae Amarum, decocts 2 times, each 2.5 hours, extracting solution merges filtration, and the filtrate after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, and being condensed into and measuring relative density 60 DEG C time is the clear paste of 1.15, add ethanol, being adjusted to determining alcohol is 70%, and cold preservation is placed, and filters, reclaim ethanol to without alcohol taste, obtain clear paste for subsequent use;
(5) step (4) gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density 60 DEG C time is the clear paste of 1.20;
(6) beta-schardinger dextrin-is taken, pour in colloid mill, add step (5) gained part clear paste and water grinding evenly, then in colloid mill, slowly drip the Mentholum of 70% dissolve with ethanol, the water added is 3 times amount of Mentholum and beta-schardinger dextrin-, step (5) the gained clear paste added and Mentholum mass ratio are 1:1, Mentholum and beta-schardinger dextrin-mol ratio are 1:1, grind 30 minutes, sucking filtration, heated-air circulation oven 40 DEG C of dry 24h, obtain Mentholum clathrate;
(7) step (6) gained Mentholum clathrate and remaining step (5) gained clear paste are mixed, then add suitable pharmaceutically acceptable adjuvant granulation;
(8) step (2) gained volatile oil is added dissolve with ethanol, spray into step (7) gained granule, conventionally make tablet.
Embodiment 3
Crude drug formula is:
Fructus Forsythiae 300g Flos Lonicerae 250 g Radix Isatidis 300 g Radix Et Rhizoma Rhei 50 g Herba Pogostemonis 90 g
Rhizoma Dryopteris Crassirhizomatis 250 g Radix Rhodiolae 90 g Mentholum 5 g Herba Ephedrae 90 g Semen Armeniacae Amarum 60 g Herba Houttuyniae 300 g Radix Glycyrrhizae 60 g Gypsum Fibrosum 300 g.
The preparation method of capsule:
(1) take Chinese crude drug according to crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 9 times amount water extraction volatile oil, carries the 4 hours time of oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with the ethanol extraction 2 times of 8 times amount 70%, each 2 hours, extracting solution merged and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adds 9 times amount soak by water to boiling, and adds Semen Armeniacae Amarum, decocts 2 times, each 2 hours, extracting solution merges filtration, and the filtrate after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, and being condensed into and measuring relative density 60 DEG C time is the clear paste of 1.12, add ethanol, being adjusted to determining alcohol is 70%, and cold preservation is placed, and filters, reclaim ethanol to without alcohol taste, obtain clear paste for subsequent use;
(5) step (4) gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density 60 DEG C time is the clear paste of 1.17;
(6) beta-schardinger dextrin-29g is taken, pour in colloid mill, add step (5) gained part clear paste 1.75g and water grinding evenly, the Mentholum of 85% dissolve with ethanol is slowly dripped again in colloid mill, the water added is 2 times amount of Mentholum and beta-schardinger dextrin-, grinds 20 minutes, sucking filtration, heated-air circulation oven 40 DEG C of dry 24h, obtain Mentholum clathrate;
(7) step (6) gained Mentholum clathrate and remaining step (5) gained clear paste are mixed, then add suitable pharmaceutically acceptable adjuvant granulation;
(8) step (2) gained volatile oil is added dissolve with ethanol, spray into step (7) gained granule, airtight, mixing, incapsulates, to obtain final product.
Embodiment 4:
Crude drug formula is:
Fructus Forsythiae 258g, Flos Lonicerae 258g, Radix Isatidis 258g, Radix Et Rhizoma Rhei 50g, Herba Pogostemonis 88g, Rhizoma Dryopteris Crassirhizomatis 258g, Radix Rhodiolae 88g, Mentholum 7.8g, Herba Ephedrae 88g, Semen Armeniacae Amarum 88g, Herba Houttuyniae 258g, Radix Glycyrrhizae 88g, Gypsum Fibrosum 258g;
Preparation method is:
(1) take Chinese crude drug according to above-mentioned prescription, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 6 times amount water extraction volatile oil, carries the 4 hours time of oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, by the ethanol extraction 2 times of 8 times amount 70%, 2 hours first times, second time 1.5 hours, extracting solution merges and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 9 times amount soak by water to boiling, adding Semen Armeniacae Amarum and decocting 2 times, 1.5 hours first times, second time 1 hour, extracting solution merges filtration, filtrate after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, being condensed into and measuring relative density 60 DEG C time is the clear paste of 1.10, and add ethanol, being adjusted to determining alcohol is 70%, cold preservation places 24 hours, filter, reclaim ethanol to without alcohol taste, obtain clear paste for subsequent use;
(5) step (4) gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density 60 DEG C time is the clear paste of 1.17;
(6) beta-schardinger dextrin-is taken, pour in colloid mill, add step (5) gained part clear paste and water grinding evenly, then in colloid mill, slowly drip the Mentholum of 75% dissolve with ethanol, the water added is 2 times amount of Mentholum and beta-schardinger dextrin-, step (5) the gained clear paste added and Mentholum mass ratio are 0.65:1, Mentholum and beta-schardinger dextrin-mol ratio are 1:0.8, grind 20 minutes, sucking filtration, heated-air circulation oven 40 DEG C of dry 24h, obtain Mentholum clathrate;
(7) step (6) gained Mentholum clathrate and remaining step (5) gained clear paste are mixed, then add starch 138 grams, use 85% alcohol granulation;
(8) step (2) gained volatile oil is added dissolve with ethanol, spray into step (7) gained granule, airtight, mixing, loads 1000 capsules, to obtain final product.
Embodiment 5:
Crude drug formula is:
Fructus Forsythiae 210g, Flos Lonicerae 280g, Radix Isatidis 210g, Radix Et Rhizoma Rhei 55g, Herba Pogostemonis 75g, Rhizoma Dryopteris Crassirhizomatis 280g, Radix Rhodiolae 75g, Mentholum 8.5g, Herba Ephedrae 75g, Semen Armeniacae Amarum 100g, Herba Houttuyniae 210g, Radix Glycyrrhizae 100g, Gypsum Fibrosum 210g;
Preparation method is:
(1) take Chinese crude drug according to above-mentioned prescription, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 5 times amount water extraction volatile oil, carries the 4 hours time of oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, by the ethanol extraction 2 times of 6 times amount 50%, 3 hours first times, second time 1 hour, extracting solution merges and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 7 times amount soak by water to boiling, adding Semen Armeniacae Amarum and decocting 2 times, 0.5 hour first time, second time 2.5 hours, extracting solution merges filtration, filtrate after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, being condensed into and measuring relative density 60 DEG C time is the clear paste of 1.10, and add ethanol, being adjusted to determining alcohol is 70%, cold preservation places 24 hours, filter, reclaim ethanol to without alcohol taste, obtain clear paste for subsequent use;
(5) step (4) gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density 60 DEG C time is the clear paste of 1.20;
(6) beta-schardinger dextrin-is taken, pour in colloid mill, add step (5) gained part clear paste and water grinding evenly, then in colloid mill, slowly drip the Mentholum of 99% dissolve with ethanol, the water added is 2 times amount of Mentholum and beta-schardinger dextrin-, step (5) the gained clear paste added and Mentholum mass ratio are 0.75:1, Mentholum and beta-schardinger dextrin-mol ratio are 1:0.8, grind 20 minutes, sucking filtration, heated-air circulation oven 40 DEG C of dry 24h, obtain Mentholum clathrate;
(7) step (6) gained Mentholum clathrate and remaining step (5) gained clear paste are mixed, then add starch 134 grams, use 85% alcohol granulation;
(8) step (2) gained volatile oil is added dissolve with ethanol, spray into step (7) gained granule, formulation method is made tablet and be get final product routinely.
Embodiment 6:
Crude drug formula is:
Fructus Forsythiae 280g, Flos Lonicerae 210g, Radix Isatidis 280g, Radix Et Rhizoma Rhei 45g, Herba Pogostemonis 100g, Rhizoma Dryopteris Crassirhizomatis 210g, Radix Rhodiolae 75g, Mentholum 5.5g, Herba Ephedrae 100g, Semen Armeniacae Amarum 75g, Herba Houttuyniae 280g, Radix Glycyrrhizae 75g, Gypsum Fibrosum 280g;
Preparation method is:
(1) take Chinese crude drug according to above-mentioned prescription, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 10 times amount water extraction volatile oil, carries the 4 hours time of oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, by the ethanol extraction 2 times of 10 times amount 90%, 1 hour first time, second time 3 hours, extracting solution merges and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 11 times amount soak by water to boiling, adding Semen Armeniacae Amarum and decocting 2 times, 2.5 hours first times, second time 0.5 hour, extracting solution merges filtration, filtrate after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, be condensed into the clear paste measuring relative density 1.15 60 DEG C time, add ethanol, being adjusted to determining alcohol is 70%, cold preservation places 24 hours, filter, reclaim ethanol to without alcohol taste, obtain clear paste for subsequent use;
(5) step (4) gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density 60 DEG C time is the clear paste of 1.17;
(6) beta-schardinger dextrin-is taken, pour in colloid mill, add step (5) gained part clear paste and water grinding evenly, then in colloid mill, slowly drip the Mentholum of 95% dissolve with ethanol, the water added is 2 times amount of Mentholum and beta-schardinger dextrin-, step (5) the gained clear paste added and Mentholum mass ratio are 0.85:1, Mentholum and beta-schardinger dextrin-mol ratio are 1:0.8, grind 20 minutes, sucking filtration, heated-air circulation oven 40 DEG C of dry 24h, obtain Mentholum clathrate;
(7) step (6) gained Mentholum clathrate and remaining step (5) gained clear paste are mixed, then add suitable pharmaceutically acceptable adjuvant granulation;
(8) step (2) gained volatile oil is added dissolve with ethanol, spray into step (7) gained granule, formulation method is made pill and be get final product routinely.
Embodiment 7:
Crude drug formula is:
Fructus Forsythiae 170g, Flos Lonicerae 170g, Herba Ephedrae (processed) 57g, Semen Armeniacae Amarum (parched) 57g, Gypsum Fibrosum 170g, Radix Isatidis 170g, Rhizoma Dryopteris Crassirhizomatis 170g, Herba Houttuyniae 170g, Herba Pogostemonis 57g, Radix Et Rhizoma Rhei 34g, Radix Rhodiolae 57g, Mentholum 5.0g, Radix Glycyrrhizae Preparata 57g;
Preparation method:
(1) extraction process:
(1) take Chinese crude drug according to above-mentioned recipe quantity, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis adds 6 times amount water extraction volatile oil, and carry oil time 4h, collect volatile oil, oil yield is 0.33 ± 0.05%, and for subsequent use after extracting liquid filtering, residue discards;
(3) Fructus Forsythiae, Herba Ephedrae (processed), Herba Houttuyniae, Radix Et Rhizoma Rhei, with the ethanol extraction 2 times of 8 times amount 70%, 2 hours first times, second time 1.5 hours, extracting liquid filtering, filtrate merges, and reclaims ethanol to without alcohol taste, for subsequent use;
(4) Flos Lonicerae, Semen Armeniacae Amarum (parched), Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae Preparata, Radix Rhodiolae, add 9 times amount soak by water to boiling, add Semen Armeniacae Amarum (parched), decoct 2 times, 1.5 hours first times, second time 1 hour, extracting liquid filtering, filtrate merge add simultaneously step (2) Herba Pogostemonis carry oil after aqueous solution, being condensed into 60 DEG C of mensuration relative densities is 1.10 clear paste, add 95% ethanol, limit edged stirs, to determining alcohol 70%, cold preservation places 24 hours, filter, filtrate recycling ethanol, to without alcohol taste, obtains clear paste for subsequent use;
(5) step (4) gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density 60 DEG C time is the clear paste of 1.17;
(6) beta-schardinger dextrin-is taken, pour in colloid mill, add step (5) gained part clear paste and water grinding evenly, then in colloid mill, slowly drip the Mentholum of 95% dissolve with ethanol, the water added is 3 times amount of Mentholum and beta-schardinger dextrin-, step (5) the gained clear paste added and Mentholum mass ratio are 0.25:1, Mentholum and beta-schardinger dextrin-mol ratio are 1:0.8, grind 20 minutes, sucking filtration, heated-air circulation oven 40 DEG C of dry 24h, obtain Mentholum clathrate;
(2) preparation process:
(7) pharmaceutical formulation is: step (5) gained clear paste 335.5g, step (6) gained Mentholum clathrate 5g, step (2) gained patchouli oil 0.2ml, Icing Sugar 342.5g, dextrin 514.0g;
(8) granulate: remaining step (5) gained clear paste and step (6) gained Mentholum clathrate are mixed, by Icing Sugar and dextrin mix homogeneously, make binding agent soft material with thick paste, 14 eye mesh screens are granulated, 60-65 DEG C of oven dry, 10 eye mesh screen granulate;
(9) subpackage: sift out fine powder appropriate, Herba Pogostemonis Volatile oil is added ethanol in proper amount, dissolves, sprays in fine powder, mix homogeneously, and mix homogeneously with granule, airtight half an hour, and pack, obtaining final product, above prescription can be made into granule 1000g.
Preparation of the present invention is not only confined to above-mentioned several preparation, according to the character of medicine, can also make the preparation that other are possible.
Claims (8)
1. a preparation method for Chinese medicine composition, described Chinese medicine composition is made up of the crude drug of following weight portion: Fructus Forsythiae 250-300, Flos Lonicerae 250-300, Radix Isatidis 250-300, Radix Et Rhizoma Rhei 50-60, Herba Pogostemonis 60-90, Rhizoma Dryopteris Crassirhizomatis 250-300, Radix Rhodiolae 60-90, Mentholum 5-8, Herba Ephedrae 60-90, Semen Armeniacae Amarum 60-90, Herba Houttuyniae 250-300, Radix Glycyrrhizae 60-90, Gypsum Fibrosum 250-300; It is characterized in that described Chinese medicine composition is made up of following steps:
(1) take Chinese crude drug according to crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, extracting in water volatile oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with ethanol extraction 2 times, extracting solution merges and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, decocting with water to boiling, adding Semen Armeniacae Amarum, decoct 2 times, extracting solution merges filtration, and the filtrate after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, and is condensed into clear paste, add ethanol, reconciling to determining alcohol is 70%, and cold preservation is placed, and filters, reclaim ethanol to without alcohol taste, obtain clear paste for subsequent use;
(5) step (4) gained clear paste and step (3) gained alcohol extract are merged, be condensed into clear paste;
(6) beta-schardinger dextrin-is got, pour in colloid mill, add step (5) gained part clear paste and water grinding evenly, the Mentholum of dissolve with ethanol is slowly dripped again in colloid mill, step (5) the gained clear paste added and the mass ratio of Mentholum are 0.25-1:1, grinding, filter, drying, obtains Mentholum clathrate;
(7) step (6) gained Mentholum clathrate and remaining step (5) gained clear paste are mixed, then add suitable pharmaceutically acceptable adjuvant granulation;
(8) step (2) gained volatile oil is added dissolve with ethanol, spray into step (7) gained granule, conventionally make preparation.
2. preparation method according to claim 1, it is characterized in that the amount of the water added in described step (6) is 2-3 times of Mentholum and beta-schardinger dextrin-, ethanol used is 70-99% ethanol, and Mentholum and beta-schardinger dextrin-mol ratio are 1:0.8-1, and milling time is 20-30 minute.
3. preparation method according to claim 1, is characterized in that being made up of the crude drug of following weight portion:
Fructus Forsythiae 250 Flos Lonicerae 300 Radix Isatidis 250 Radix Et Rhizoma Rhei 60 Herba Pogostemonis 60
Rhizoma Dryopteris Crassirhizomatis 300 Radix Rhodiolae 60 Mentholum 8 Herba Ephedrae 60 Semen Armeniacae Amarum 90
Herba Houttuyniae 250 Radix Glycyrrhizae 90 Gypsum Fibrosum 250.
4. preparation method according to claim 1, is characterized in that being made up of the crude drug of following weight portion:
Fructus Forsythiae 300 Flos Lonicerae 250 Radix Isatidis 300 Radix Et Rhizoma Rhei 50 Herba Pogostemonis 90
Rhizoma Dryopteris Crassirhizomatis 250 Radix Rhodiolae 90 Mentholum 5 Herba Ephedrae 90 Semen Armeniacae Amarum 60
Herba Houttuyniae 300 Radix Glycyrrhizae 60 Gypsum Fibrosum 300.
5. preparation method according to claim 1, is characterized in that being made up of the crude drug of following weight portion:
Fructus Forsythiae 255 Flos Lonicerae 255 Radix Isatidis 255 Radix Et Rhizoma Rhei 51 Herba Pogostemonis 85
Rhizoma Dryopteris Crassirhizomatis 255 Radix Rhodiolae 85 Mentholum 7.5 Herba Ephedrae 85 Semen Armeniacae Amarum 85
Herba Houttuyniae 255 Radix Glycyrrhizae 85 Gypsum Fibrosum 255.
6. the preparation method according to any one of claim 1-5, it is characterized in that described Radix Glycyrrhizae is Radix Glycyrrhizae Preparata, Herba Ephedrae is Herba Ephedrae (processed), and described Semen Armeniacae Amarum is Semen Armeniacae Amarum (parched).
7. the preparation method according to any one of claim 1-5, is characterized in that described pharmaceutical dosage form is capsule, tablet, powder, oral liquid, pill, tincture, syrup, suppository, gel, spray or injection.
8. preparation method according to claim 7, is characterized in that described granule is made up of following steps:
(1) take Chinese crude drug according to crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 8-10 times amount water extraction volatile oil, carries the 4 hours time of oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with the ethanol extraction 2 times of 6-10 times amount 50-90%, each 1-3 hour, extracting solution merges and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adds 7-11 times amount soak by water to boiling, and adds Semen Armeniacae Amarum, decocts 2 times, each 0.5-2.5 hour, extracting solution merges filtration, and the filtrate after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, and being condensed into and measuring relative density 60 DEG C time is the clear paste of 1.10-1.15, add ethanol, being adjusted to determining alcohol is 70%, and cold preservation is placed, and filters, reclaim ethanol to without alcohol taste, obtain clear paste for subsequent use;
(5) step (4) gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density 60 DEG C time is the clear paste of 1.15-1.20;
(6) beta-schardinger dextrin-is got, pour in colloid mill, add step (5) gained part clear paste and water grinding evenly, then in colloid mill, slowly drip the Mentholum of 70-99% dissolve with ethanol, the water added is the 2-3 times amount of Mentholum and beta-schardinger dextrin-, step (5) the gained clear paste added and the mass ratio of Mentholum are 0.25-1:1, Mentholum and beta-schardinger dextrin-mol ratio are 1:0.8-1, and grinding 20-30 minute, filters, drying, obtains Mentholum clathrate;
(7) step (6) gained Mentholum clathrate and remaining step (5) gained clear paste are mixed, then add suitable pharmaceutically acceptable adjuvant granulation;
(8) step (2) gained volatile oil is added dissolve with ethanol, spray into step (7) gained granule, airtight, mixing, pack, to obtain final product.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109422780A (en) * | 2017-09-05 | 2019-03-05 | 北京以岭药业有限公司 | The separation method of 18 kinds of ingredients in a kind of Chinese medicine composition |
| CN109776635A (en) * | 2017-11-10 | 2019-05-21 | 北京以岭药业有限公司 | The separation method of eight kinds of ingredients in a kind of Chinese medicine composition |
| CN111494507A (en) * | 2020-06-18 | 2020-08-07 | 海南葫芦娃药业集团股份有限公司 | Preparation method of internal heat clearing tablets |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101683420A (en) * | 2008-09-26 | 2010-03-31 | 北京以岭药业有限公司 | Applications of traditional Chinese medicine composition in preparation of medicament for treating acute pharyngitis |
| CN101732467A (en) * | 2008-11-10 | 2010-06-16 | 北京以岭药业有限公司 | Application of Chinese medicinal composition in preparation of medicament for treating purulent pleurisy |
| CN101732468A (en) * | 2008-11-10 | 2010-06-16 | 北京以岭药业有限公司 | Application of Chinese medicinal composition in preparation of medicament for treating epidemic parotitis |
| CN101732469A (en) * | 2008-11-10 | 2010-06-16 | 北京以岭药业有限公司 | Application of Chinese medicinal composition in preparation of medicament for treating aphonia |
| CN101862391A (en) * | 2009-04-17 | 2010-10-20 | 北京以岭药业有限公司 | Application of Chinese medicinal composition in preparing medicament for treating human cases of bird flu |
-
2013
- 2013-10-25 CN CN201310508483.1A patent/CN104547209A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101683420A (en) * | 2008-09-26 | 2010-03-31 | 北京以岭药业有限公司 | Applications of traditional Chinese medicine composition in preparation of medicament for treating acute pharyngitis |
| CN101732467A (en) * | 2008-11-10 | 2010-06-16 | 北京以岭药业有限公司 | Application of Chinese medicinal composition in preparation of medicament for treating purulent pleurisy |
| CN101732468A (en) * | 2008-11-10 | 2010-06-16 | 北京以岭药业有限公司 | Application of Chinese medicinal composition in preparation of medicament for treating epidemic parotitis |
| CN101732469A (en) * | 2008-11-10 | 2010-06-16 | 北京以岭药业有限公司 | Application of Chinese medicinal composition in preparation of medicament for treating aphonia |
| CN101862391A (en) * | 2009-04-17 | 2010-10-20 | 北京以岭药业有限公司 | Application of Chinese medicinal composition in preparing medicament for treating human cases of bird flu |
Non-Patent Citations (1)
| Title |
|---|
| 王岳等: ""感冒颗粒中薄荷脑β-环糊精包合物的制备及应用研究"", 《中国现代药物应用》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109422780A (en) * | 2017-09-05 | 2019-03-05 | 北京以岭药业有限公司 | The separation method of 18 kinds of ingredients in a kind of Chinese medicine composition |
| CN109422780B (en) * | 2017-09-05 | 2021-07-13 | 北京以岭药业有限公司 | Method for separating eighteen components in traditional Chinese medicine composition |
| CN109776635A (en) * | 2017-11-10 | 2019-05-21 | 北京以岭药业有限公司 | The separation method of eight kinds of ingredients in a kind of Chinese medicine composition |
| CN109776635B (en) * | 2017-11-10 | 2021-08-17 | 北京以岭药业有限公司 | Method for separating eight components in traditional Chinese medicine composition |
| CN111494507A (en) * | 2020-06-18 | 2020-08-07 | 海南葫芦娃药业集团股份有限公司 | Preparation method of internal heat clearing tablets |
| WO2021253803A1 (en) * | 2020-06-18 | 2021-12-23 | 海南葫芦娃药业集团股份有限公司 | Preparation method for fire-purging tablet |
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