CN1785265A - Hepatitis B support right fast dispersion solid preparation and its preparation method - Google Patents
Hepatitis B support right fast dispersion solid preparation and its preparation method Download PDFInfo
- Publication number
- CN1785265A CN1785265A CN 200510087286 CN200510087286A CN1785265A CN 1785265 A CN1785265 A CN 1785265A CN 200510087286 CN200510087286 CN 200510087286 CN 200510087286 A CN200510087286 A CN 200510087286A CN 1785265 A CN1785265 A CN 1785265A
- Authority
- CN
- China
- Prior art keywords
- preparation
- parts
- agent
- adjuvant
- dispersion solid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
A fast dispersing solid Chinese medicine for treating hepatitis B is prepared from 11 Chinese-medicinal materials including fleece flower root, cinnamon bark, Chinese angelica root, red sage root, etc through crushing or extracting, superfine pulverizing, and mixing with disintegrant, adhesive, suspending aid, flowing aid, flavouring and coloring agent.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly relate to fast dispersion solid medicine of a kind of and Chinese medicine patent medicine hepatitis B by strengthening body resistance and preparation method thereof.
Technical background
The hepatitis B strengthening capsule prescription comes from " the Sanitation Ministry medicine standard Chinese traditional patent formulation preparation " first, form by Chinese medicines such as Radix Polygoni Multiflori, Rhizoma Polygoni Cuspidati, Rhizoma Osmundae, Cortex Cinnamomi, Alumen, Pericarpium Granati, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Semen Astragali Complanati, Radix Ginseng, Herba Ephedraes, has invigorating the liver and kidney, the benefiting QI for activating blood circulation effect; Be used for hepatitis B, dialectical Liver and kidney two deficiency syndrome that belong to are waited, and clinical manifestation is: dull pain in liver discomfort, malaise, soreness of the waist and knees, the cardiopalmus of breathing hard, spontaneous perspiration, dizzy, anorexia, light red tongue weak pulse.Hepatitis B belongs to deficient property disease category, how not to be understood by evil the bridle for a long time of damp and hot poison, suppresses clear sun liter and sends out, and function is weak, and unable getting rid of evils gone out, and due to the epidemic disease poison accumulated in the body, healthy energy was deficient, Liver and kidney two void.Clinical experience is many to be core with the disharmony between the liver and spleen, and the heresy of heat in the interior, expectorant, the stasis of blood, noxious dampness is a pathological product.Stagnation of liver-QI deficiency of spleen-QI, damage of kidney-YIN are syndrome.Therefore, the side use invigorating the liver and kidney, and the benefiting QI for activating blood circulation rule of treatment is with sending up the lucid YANG, dispel damp and hot poison heresy.The side is with Radix Polygoni Multiflori, Rhizoma Polygoni Cuspidati, Rhizoma Osmundae, eliminating toxic substances to remove stasis; Pericarpium Granati, Alumen dampness, detoxifcation; Then with Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae benefiting vital QI and blood; Semen Astragali Complanati, Cortex Cinnamomi temperature compensation Liver and kidney; Radix Ginseng tonification vigour; It is wet to be aided with the clear diuretic of Herba Ephedrae again, gathers eliminating pathogenic factor for supporting vital QI altogether, conditioning Liver and kidney, the effect of benefiting QI for activating blood circulation.
At present the hepatitis B strengthening capsule standard of in " the Sanitation Ministry medicine standard Chinese traditional patent formulation preparation ", recording (standard numbering: WS3-B-0001-89) be:
[prescription and method for making] Radix Polygoni Multiflori 15g, Rhizoma Polygoni Cuspidati 25g, Rhizoma Osmundae 50g, Cortex Cinnamomi 5g, Alumen 10g, Pericarpium Granati 6g, Radix Angelicae Sinensis 10g, Radix Salviae Miltiorrhizae 15g, Semen Astragali Complanati 10g, Radix Ginseng 10g, Herba Ephedrae 6g, more than ten simply, Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Salviae Miltiorrhizae, Alumen are pulverized and are fine powder, seven flavors such as all the other Radix Polygoni Multiflori decoct with water secondary, each 3 hours, 2 hours for the second time, collecting decoction filtered, filtrate filters into the thick paste shape, adds above-mentioned powder, and mixing is in 70～80 ℃ of dryings, be ground into fine powder, sieve, encapsulated, promptly.(this product is a capsule, every heavy 0.25g; Content is tan powder; Bitter in the mouth.)
Superfine communication technique is meant the material particles more than 3 millimeters is crushed to process below 100 microns.Researcher thinks, because granular size develops to miniaturization, thus can cause surface area and porosity to increase very significantly, so the micronizing body has unique physics and chemical property.For example, have fine solubility, dispersibility, adsorptivity, chemism etc., so application is very extensive.Studies show that all available micronizing apparatus processing of raw material such as many edible animals and plants, microorganism, medicine become superfine powder, the medicine of miniaturization has very strong surface adsorption power and affinity, therefore, has good dispersibility and dissolubility, assimilates easily.
Dispersible preparation is that a kind of water that do not need in the oral cavity can disintegrate or dissolved preparation fast.Requirement has: 1. in the oral cavity rapidly disintegrate, no grittiness, good mouthfeel, swallow easily, to the oral mucosa nonirritant.Should stipulate under the character item in the quality standard: disintegrate rapidly, no grittiness, good mouthfeel in the oral cavity; 2. set up suitable disintegration time mensuration method and limit, and be incorporated into standard; 3. to insoluble medicine, should set up suitable dissolution determination method and limit; 4. other should meet general rule requirement under the tablet item.The characteristics of dispersible preparation are fast: 1. absorption is fast, bioavailability is high; 2. instructions of taking does not need water 3. intestinal is residual few, few side effects; 4. avoid the first pass effect of liver sausage.
Hepatitis B strengthening capsule has had launch to sell at home, but in the practice, the weak point of hepatitis B strengthening capsule is that preparation technology is outmoded, and dosage form is a water honey capsule, uses inconvenience, brings many troubles for the patient of old, children and dysphagia.The present invention adopts superfine communication technique and quick dispersion technology that the hepatitis B strengthening capsule preparation is transformed, transformation process has overcome the difficulty that Chinese medicine preparation faces in the modified form process, particularly superfine communication technique and quick dispersion technology are applied to the difficulty that Chinese patent medicine faces, as moisture absorption, unstable, defectives such as technology is loaded down with trivial details, grope through screening and technology, under the constant situation of Chinese medicine preparation, prepared a kind of solid preparation similar to the hepatitis B strengthening capsule effect with quick disintegration properties.
Summary of the invention
The invention provides a kind of superfine communication technique and quick dispersion technology in conjunction with the new technique that is used for Chinese patent medicine, the quick dispersible preparation of particularly making in conjunction with the technology of preparing of Chinese patent medicine hepatitis B strengthening capsule similar to the hepatitis B strengthening capsule effect obtained beyond thought effect.
Quick dispersible preparation of the present invention be with the Chinese medicine principal agent through after pulverizing and/or extracting processing, with at least a disintegrating agent with meet water to form full-bodied swelling adjuvant formulated, said preparation is met water disintegrate and form uniform viscosity suspension rapidly.
The quick dispersible preparation of the present invention, the prescription of its Chinese medicine part is composed as follows:
15 parts of Radix Polygoni Multiflori, 25 parts of Rhizoma Polygoni Cuspidati, 50 parts of Rhizoma Osmundae, 5 parts of Cortex Cinnamomis, 10 parts in Alumen, 6 parts of Pericarpium Granatis, 10 parts of Radix Angelicae Sinensis, 15 parts of Radix Salviae Miltiorrhizaes, 10 parts of Semen Astragali Complanatis, 10 parts of Radix Ginsengs, 6 parts in Herba Ephedrae,
More than form, part is a weight portion, calculates with crude drug, if with 10 grams is unit, promptly 15 parts are equivalent to 150 grams, more than form to can be made into 1000 agent medicine preparations, described 1000 doses of fingers, the final drug preparation of making, as make 1000 of capsule preparations, 1000 in tablet, granule 1000g, oral liquid 1000ml etc., also can make big packing as granule, as the 100-500 bag, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, and for especial patient, the proportioning of can corresponding adjustment forming increases or reduce being no more than 100%.
Single medicinal material, especially ministerial drug and adjuvant drug in more than forming also can be replaced by the suitable Chinese medicine with identical property of medicine, and its drug effect of the Chinese medicine preparation after the replacement is constant.
Its adjuvant of quick dispersible preparation of the present invention is significant to the present invention, and adjuvant of the present invention is selected from disintegrating agent, adhesive, suspending (thickening) agent, fluidizer, correctives, rectifys toner.Wherein suspending (thickening) agent, strong toner add according to the needs of preparation, if preparation does not need, just do not add.
The used adjuvant of the present invention obtains through screening, wherein disintegrating agent is selected from, super carboxymethyl starch sodium (upright collapsing), carboxymethyl starch sodium (CMS-Na), low-substituted hydroxypropyl cellulose (LS-HPC), crospolyvinylpyrrolidone (polyvinylpolypyrrolidone, PVPP), cross-linking sodium carboxymethyl cellulose (CCMC-Na, CCNa), low-substituted hydroxypropyl cellulose (LHPC) etc.For the less starch of swellbility, microcrystalline Cellulose etc. can guarantee the quick disintegrate of preparation (also can use under＜3min) the situation, but preferably swellbility greater than the disintegrating agent of 5ml/g.Adhesive is selected from polyvidone (PVP), for hyprolose sodium (HPMC); Suspending agent is selected from xanthan gum, Ka Baimu (CARBOMER), HPMC, melon glue.Fluidizer is selected from differential silica gel, Pulvis Talci, magnesium stearate.Correctives is selected from various essence, as Apis essence, green tea essence, Fructus Citri tangerinae essence, apple essence, flavoring pineapple essence, grape essence etc.Strong toner is any pharmaceutically useful pigment or makes the final user mode of preparation present the coloring matter that meets medicinal standard of certain color state.
The present invention also provides the preparation method of quick dispersible preparation of the present invention, this preparation method comprises, Chinese medicine pulverizing medicinal materials and/or extraction with above proportioning, ground product or extract obtain product after drying, through micronizing, obtain medicinal powder or the extract powder of particle diameter less than 75 μ m, this powder is as active constituents of medicine, mixed in the proper ratio with adjuvant through micronizing, make quick dispersible preparation of the present invention with the preparation technique of galenic pharmacy routine.Chinese medicine pulverizing medicinal materials described in this method can be according to hepatitis B strengthening capsule standard (the standard numbering: WS3-B-0001-89) be: Radix Polygoni Multiflori 15g, Rhizoma Polygoni Cuspidati 25g, Rhizoma Osmundae 50g of traditional method as recording in " the Sanitation Ministry medicine standard Chinese traditional patent formulation preparation ", Cortex Cinnamomi 5g, Alumen 10g, Pericarpium Granati 6g, Radix Angelicae Sinensis 10g, Radix Salviae Miltiorrhizae 15g, Semen Astragali Complanati 10g, Radix Ginseng 10g, Herba Ephedrae 6g, more than ten simply, Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Salviae Miltiorrhizae, Alumen is pulverized and is fine powder, and seven flavors such as all the other Radix Polygoni Multiflori decoct with water secondary, each 3 hours, 2 hours for the second time, collecting decoction filters, and filtrate filters into the thick paste shape, add above-mentioned powder, mixing in 70～80 ℃ of dryings, is ground into fine powder, sieve, promptly.
Described extraction can use decocting in water to extract, alcohol reflux, and ethanol percolation extracts, and the decocting in water precipitate with ethanol extracts, and any one in the multiple extracting method such as alcohol heavy extraction to boil water selected to use as required, and preferably decocting in water extracts.Decocting in water adopts and adds water 10-15 doubly, and decocting boils 2-3 time, and 1-3 hour for the first time, 1-3 hour for the second time, 1-3 hour for the third time, collecting decoction filtered, and concentrate drying obtains extract extractum.
In order to provide preparation good quick dispersive ability, need the granularity of strict control active constituents of medicine and adjuvant, just grain diameter is little.Therefore, the process characteristic of preparation of the present invention is, before the preparations shaping active constituents of medicine and adjuvant is all carried out micronization; Its objective is the wettability that increases the powder particle surface, promote the medicine stripping.The present invention adopts the method for micronizing, obtains Chinese medicine medicinal powder or the Chinese medicine extract of particle diameter less than 75 μ m, then with particle diameter quite or littler adjuvant is mixed evenly makes pharmaceutical preparation.For tablet, can adopt powder straight forming, wet granulation molding or dry granulation molding to prepare.
Superfine communication technique of the present invention, principal agent of the present invention and adjuvant are processed into particle diameter less than 75 μ m by existing superfine grinding method, are preferably less than 30 μ m, most preferably be micro powder granule less than 10 μ m, at present, micronization technology has two kinds of chemical method and Mechanical Method.Chemical synthesis can make micron order, submicron order even nano level powder body.The mechanical crushing method cost is low, output is big, be the preparation ultrafine powder main means, now large-scale application in commercial production.Micronizing can be divided into dry pulverization process and waterproof pulverization: different according to the principle that produces crush force in the crushing process, dry pulverization process has several forms such as air-flowing type, dither formula, screw (rod) mill formula, paddle type mill and Self-milling; Waterproof pulverization mainly is colloid mill and homogenizer.The present invention can obtain the product of particle diameter less than 75 μ m by above arbitrary method, preferably uses air-flow dry powder comminuting method.
Therefore, the disintegrating agent of the present invention in material principal agent of guaranteeing to use and adjuvant, adhesive, suspending (thickening) agent, fluidizer, correctives, to rectify toner etc. evenly mixed under all having less than the situation of 75 μ m particle diameters, the preparation solid preparation; Said preparation also has the high dispersive characteristic when being beneficial to absorption, can better absorb, and can take with solid form, also can add to take after making preparation be distributed in the liquid behind the liquid when taking, as use mixing in water for oral taking.
Quick dispersible preparation of the present invention, the part by weight of its principal agent and adjuvant is 100: 1～600, preferably 100: 50-400, more preferably 100: 100-200, wherein the part by weight of principal agent and disintegrating agent is 100: 10～500, preferably 100: 100-400, more preferably 100: 200-300.
Quick dispersible preparation of the present invention includes but not limited to fast disintegrating tablet as oral cavity disintegration tablet, and it can directly place the oral cavity, disperses by saliva, and disintegrate rapidly, no grittiness, good mouthfeel are beneficial to and swallow in the oral cavity.Also can be made into dispersible tablet, disperse fast in water, its dispersion liquid does not have grittiness, good mouthfeel, absorbs rapidly.
The weight proportion of principal agent of the present invention and adjuvant is preferably following proportioning:
100 parts of principal agents
Disintegrating agent, 10-500 part
Adhesive, 1-10 part
Suspending (thickening) agent, 0-10 part
Fluidizer, 0.5-5 part
Correctives, 0-2 part
Rectify toner.0-2 part
Wherein, preferred disintegrating agent is super carboxymethyl starch sodium (upright collapsing), carboxymethyl starch sodium (CMS-Na), microcrystalline Cellulose.Preferred adhesive is selected from polyvidone (PVP), for hyprolose sodium (HPMC).Preferred fluidizer is a differential silica gel.Preferred correctives is Apis essence, green tea essence.
Most preferred prescription composition of the present invention is listed in the embodiment of the invention.
Quick dispersible preparation of the present invention, its Chinese medicine preparation is identical with hepatitis B strengthening capsule, and patent medicine has invigorating the liver and kidney, the benefiting QI for activating blood circulation effect; Be used for hepatitis B.
Medicine in the embodiment of the invention has been carried out experimentation, proved that quick dispersible preparation of the present invention is better than the conventional formulation hepatitis B strengthening capsule on curative effect, can reach the effect of conventional medicament, more obtained patient's welcome in the use with littler dosage.
The invention has the advantages that: the present invention is on the basis of the hepatitis B strengthening capsule prescription of determined curative effect and preparation process, adopt vanguard technology technology such as superfine communication technique, increased the dispersion of medical material effectively, and use quickly disintegrated adjuvant, make preparation have the feature of quick dispersion and very big degree of scatter simultaneously, thereby it is convenient that the more former dosage form of medicine is taken, by quick disintegrate (＜3min) reach the purpose that improves bioavailability.Can put into when dispersible tablet uses and take after water disperses, or directly place mouth, become liquid apace, and for this series products of hepatitis B by strengthening body resistance preparation, be particularly suitable for making preparation of the present invention, can solve as dysphagia person (especially old man, child), or the patient's medication problem under the special environment that can not obtain water, provide a great convenience.Wherein particle diameter less than the medicinal powder of 75 μ m or the extract powder adjuvant identical or littler with particle diameter mixed be key factor of the present invention.
Outside the requirement to corresponding drug standard of the quality evaluation of quickly disintegrated solid preparation and official preparation general rule, preparation disintegration time high spot reviews content, disintegration time＜3min.
It has taking convenience, absorption is fast, bioavailability is high and untoward reaction is few, and steady quality is non-hygroscopic, technology is simple etc., the patient who is particularly suitable for old, children and dysphagia takes, and can characteristics such as produce with conventional tablet production technology and equipment, is a kind of good novel form.
The specific embodiment
With specific embodiment the present invention is elaborated below.Hepatitis B support right fast dispersion solid preparation of the present invention, and the solid preparation with quick disintegrate feature (as dispersible tablet) of the side of deriving is to make by the represented method of following embodiment, and involved method is the technological means that those skilled in the art can grasp and use.Following examples are implementation example of the present invention, and the part embodiment for claim of the present invention should not be construed as the restriction to claim of the present invention of going up in all senses.
Embodiment 1
Radix Polygoni Multiflori 15g part, 25 parts of Rhizoma Polygoni Cuspidati, 50 parts of Rhizoma Osmundae, 5 parts of Cortex Cinnamomis, 10 parts in Alumen, 6 parts of Pericarpium Granatis, 10 parts of Radix Angelicae Sinensis, 15 parts of Radix Salviae Miltiorrhizaes, 10 parts of Semen Astragali Complanatis, 10 parts of Radix Ginsengs, 6 parts in Herba Ephedrae is got Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Salviae Miltiorrhizae, Alumen and pulverizes and be fine powder, seven flavors such as all the other Radix Polygoni Multiflori decoct with water secondary, and each 3 hours, 2 hours for the second time, collecting decoction filters, and filtrate filters into the thick paste shape, add above-mentioned powder, mixing in 70～80 ℃ of dryings, is ground into fine powder, be crushed to 300 orders, per 100 parts of powder and adjuvant are evenly mixed, granulate, and promptly get (preparation prescription sees Table 1).During use, under the sucking clothes, one time 1～2; Or drop into and take after scattering in about 150～200ml water; 2～3 times on the one.
Table 1 preparation prescription and main evaluation result thereof
| The principal agent amount 1 | Disintegrating agent/consumption | Adhesive/consumption | Fluidizer/consumption | Other 2 | Disintegration time/min |
| 100 | CMS-Na/15 CMS-Na/50 CMS-Na/90 CMS-Na/200 | PVP/3 PVP/3 PVP/3 PVP/4 | Differential silica gel/1 | Green tea essence/0.5% xylitol/0.5% | 2.5 0.6 0.5 0.5 |
Annotate: (1) is 100 parts with the principal agent amount, and other supplementary product consumption is a relative quantity, umber.(2) other is the tender agent etc. of distinguishing the flavor of.
Claims (10)
1. hepatitis B support right fast dispersion solid preparation, make 15 parts of Radix Polygoni Multiflori, 25 parts of Rhizoma Polygoni Cuspidati by following Chinese medicine raw materials by weight proportion, 50 parts of Rhizoma Osmundae, 5 parts of Cortex Cinnamomis, 10 parts in Alumen, 6 parts of Pericarpium Granatis, 10 parts of Radix Angelicae Sinensis, 15 parts of Radix Salviae Miltiorrhizaes, 10 parts of Semen Astragali Complanatis, 10 parts of Radix Ginsengs, 6 parts in Herba Ephedrae, it is characterized in that described fast dispersion solid medicine is after above-mentioned Chinese medicine is pulverized or extracted, to carry out micronizing, obtain principal agent, this principal agent be selected from disintegrating agent, adhesive, suspending agent, fluidizer, correctives, the adjuvant of rectifying toner mixes, and makes preparation with the galenic pharmacy routine techniques, and wherein the granularity of principal agent that all uses and adjuvant is all less than 75 μ m particle diameters.
2. the fast dispersion solid medicine of claim 1 is characterized in that, wherein the granularity of principal agent that all uses and adjuvant is all less than 30 μ m particle diameters.
3. the fast dispersion solid medicine of claim 1 is characterized in that, wherein the granularity of principal agent that all uses and adjuvant is all less than 10 μ m particle diameters.
4. the fast dispersion solid medicine of claim 1, it is characterized in that, wherein disintegrating agent is selected from, super carboxymethyl starch sodium, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, low-substituted hydroxypropyl cellulose, starch, microcrystalline Cellulose; Adhesive is selected from polyvidone, for hyprolose sodium; Suspending agent is selected from xanthan gum, Ka Baimu, HPMC, melon glue; Fluidizer is selected from differential silica gel, Pulvis Talci, magnesium stearate; Correctives is selected from various essence, and strong toner is any pharmaceutically useful pigment or makes the final user mode of preparation present the coloring matter that meets medicinal standard of certain color state.
5. the fast dispersion solid medicine of claim 1 is characterized in that, is tablet, and it is composed as follows:
100 parts of principal agents
Disintegrating agent, 10-500 part
Adhesive, 1-10 part
Suspending agent, 0-10 part
Fluidizer, 0.5-5 part
Correctives, 0-2 part
Rectify toner.0-2 part.
6. the preparation method of the described fast dispersion solid medicine of claim 1 is characterized in that, the process following steps:
(1) get respectively distinguish the flavor of medical material or decoction pieces according to the Chinese medicine preparation in the claim 1, after pulverizing or extracting, carry out the micronizing of granularity less than 75 μ m particle diameters, standby;
(2) resulting micropowders identical or littler with particle diameter is selected from following adjuvant: disintegrating agent, adhesive, suspending agent, fluidizer, correctives or strong toner mix homogeneously are prepared into preparation.
7. preparation method according to claim 6, it is characterized in that, wherein disintegrating agent is selected from, super carboxymethyl starch sodium, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, low-substituted hydroxypropyl cellulose, starch, microcrystalline Cellulose; Adhesive is selected from polyvidone, for hyprolose sodium; Suspending agent is selected from xanthan gum, Ka Baimu, HPMC, melon glue; Fluidizer is selected from differential silica gel, Pulvis Talci, magnesium stearate; Correctives is selected from various essence, and strong toner is any pharmaceutically useful pigment or makes the final user mode of preparation present the coloring matter that meets medicinal standard of certain color state.
8. according to the described preparation method of claim 6, it is characterized in that the ratio of principal agent and adjuvant is 100: 1～600 in the preparation.
9. according to the described preparation method of claim 6, it is characterized in that the ratio of principal agent and disintegrating agent is 100: 10～500 in the preparation.
10. according to the described preparation method of claim 6, it is characterized in that described preparation is a tablet, adopt powder straight forming, wet granulation molding or dry granulation molding.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100872862A CN100384405C (en) | 2005-07-28 | 2005-07-28 | Hepatitis B support right fast dispersion solid preparation and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100872862A CN100384405C (en) | 2005-07-28 | 2005-07-28 | Hepatitis B support right fast dispersion solid preparation and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1785265A true CN1785265A (en) | 2006-06-14 |
| CN100384405C CN100384405C (en) | 2008-04-30 |
Family
ID=36782934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100872862A Expired - Fee Related CN100384405C (en) | 2005-07-28 | 2005-07-28 | Hepatitis B support right fast dispersion solid preparation and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100384405C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397346A (en) * | 2011-11-26 | 2012-04-04 | 苏州派腾生物医药科技有限公司 | Method for preparing hepatitis B health-energy-strengthening capsule |
| CN102579870A (en) * | 2012-02-28 | 2012-07-18 | 山东阿如拉药物研究开发有限公司 | Traditional Tibetan medicine composition and preparation for treating liver diseases, and preparation method thereof |
| CN111671797A (en) * | 2020-06-17 | 2020-09-18 | 广州白云山医药集团股份有限公司白云山制药总厂 | Pharmaceutical composition for preventing and treating atherosclerosis and preparation and application methods thereof |
-
2005
- 2005-07-28 CN CNB2005100872862A patent/CN100384405C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397346A (en) * | 2011-11-26 | 2012-04-04 | 苏州派腾生物医药科技有限公司 | Method for preparing hepatitis B health-energy-strengthening capsule |
| CN102579870A (en) * | 2012-02-28 | 2012-07-18 | 山东阿如拉药物研究开发有限公司 | Traditional Tibetan medicine composition and preparation for treating liver diseases, and preparation method thereof |
| CN111671797A (en) * | 2020-06-17 | 2020-09-18 | 广州白云山医药集团股份有限公司白云山制药总厂 | Pharmaceutical composition for preventing and treating atherosclerosis and preparation and application methods thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100384405C (en) | 2008-04-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1785340A (en) | Compound bovine bezoar stomach clearing fast dispersion solid preparation and its preparation method | |
| CN100515457C (en) | Mugwort and cyperus palace warming fast dispersion solid preparation and its preparation method | |
| CN1785395A (en) | Spleen-tonifying Zisheng fast dispersion solid preparation and its preparation method | |
| CN1785336A (en) | Tongyou dryness moistening fast dispersion solid preparation and its preparation method | |
| CN1824012A (en) | Perfect major supple mentation fast dispersion solid preparation and its making method | |
| CN100488493C (en) | Antelope horn fast dispersion solid preparation for clearing lung | |
| CN1785241A (en) | Motherwort quick dispersion solid prepn. and its prepn. method | |
| CN1785360A (en) | Infant spleen-tonifying fast dispersion solid preparation and its preparation method | |
| CN100515471C (en) | Liver kidney nourishing fast dispersion solid preparation and its preparation method | |
| CN100384405C (en) | Hepatitis B support right fast dispersion solid preparation and its preparation method | |
| CN1785397A (en) | Child food digesting stomach fortifying fast dispersion solid preparation and its preparation method | |
| CN100515409C (en) | Lumbar invigorating kidney fortifying fast dispersion solid medicine and its preparation method | |
| CN100515399C (en) | Zuojin fast dispersion solid medicine and its preparation method | |
| CN1785398A (en) | Kunshun fast dispersion solid preparation and its preparation method | |
| CN100488492C (en) | Flowery knotwood root fast dispersion solid preparation | |
| CN1785345A (en) | Six ingredient rehmannia fast dispersion solid preparation and its preparation method | |
| CN100364500C (en) | Fast dispersion solid preparation and its preparation method | |
| CN1824140A (en) | Anemarrhena, phello dendron and rehmannia fast dispersion solid medicinal preparation and its manufacturing method | |
| CN100515458C (en) | Fast dispersion solid preparation for treating leukorrhea and its preparation method | |
| CN100384402C (en) | Jinsang sanjie fast dispersion solid preparation for treating throat and its preparation method | |
| CN100515396C (en) | Preparation method of Dingkun fast dispersion solid preparation | |
| CN1785259A (en) | Jinsuo emission-arresting fast dispersing solid preparation and its preparation method | |
| CN1785369A (en) | Kunbao (female treasure) fast dispersion solid preparation and its preparation method | |
| CN100515411C (en) | Fast dispersion solid preparation for Child and its preparation method | |
| CN1785393A (en) | Stomach harmonizing liver calming fast dispersion solid preparation and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP03 | Change of name, title or address |
Address after: 1266 No. 330052 Nanchang Huiren Jiangxi economic and Technological Development Zone Avenue. Patentee after: JIANGXI HUIREN PHARMACEUTICAL CO.,LTD. Address before: 330043 1189 Yingbin Avenue, Nanchang, Jiangxi Patentee before: Jiangxi Huiren Pharmaceutical Co.,Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080430 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |