CN1824012A - Perfect major supple mentation fast dispersion solid preparation and its making method - Google Patents
Perfect major supple mentation fast dispersion solid preparation and its making method Download PDFInfo
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Abstract
A Chinese medicine Shiquan Dabu in the form of fast dispersing solid is prepared from 10 Chinese-medicinal materials including pilose asiabell root, liquorice root, Chinese angelica root, Chuan-xiong rhizome, etc.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly relate to a kind of perfect major supple mentation fast dispersion solid preparation and preparation method thereof.
Technical background
" 2005 editions contained bolus of ten powerful tonics of Chinese pharmacopoeia have the temperature compensation QI and blood.Be used for QI and blood deficiency, pale complexion, the cardiopalmus of breathing hard, dizzy spontaneous perspiration, fatigue and asthenia, extremity are not warm, menorrhagia.It consists of: Radix Codonopsis 80g, and the Rhizoma Atractylodis Macrocephalae (stir-fry) 80g, Poria 80g, Radix Glycyrrhizae Preparata 40g, Radix Angelicae Sinensis 120g, Rhizoma Chuanxiong 40g, the Radix Paeoniae Alba (wine stir-fry) 80g, Radix Rehmanniae Preparata 120g, Radix Astragali Preparata 80g, Cortex Cinnamomi 20g etc., its preparation method is: above ten flavors, be ground into fine powder, sieve mixing.Every 100g powder adds an amount of water pill with refined honey 35～50g, and drying is made water-honeyed pill; Or add refined honey 100～120g and make big honeyed pills, promptly.
Superfine communication technique be meant with material particles be crushed to micron even nanometer and the process of micropowder, the gained micropowder has some special physicochemical properties that general microgranule does not have, as fine solubility, dispersibility, adsorptivity, chemism etc., under suitable condition, can be made into powder after the medical material micronizing, granule, tablet, suspensoid etc., the pharmaceutical preparation that the medical material of miniaturization is made has very strong surface adsorption power and affinity, therefore, have good dispersibility and dissolubility, assimilate easily.
Dispersible preparation is that a kind of water that do not need in the oral cavity can disintegrate or dissolved preparation fast.Specification requirement: 1. should be in the oral cavity rapidly disintegrate, no grittiness, good mouthfeel, swallow easily, to the oral mucosa nonirritant.Should stipulate under the character item in the quality standard: disintegrate rapidly, no grittiness, good mouthfeel in the oral cavity; 2. set up suitable disintegration time mensuration method and limit, and be incorporated into standard; 3. to insoluble medicine, should set up suitable dissolution determination method and limit; 4. other should meet general rule requirement under the tablet item.The characteristics of dispersible preparation are fast: 1. absorption is fast, bioavailability is high; 2. instructions of taking does not need water 3. intestinal is residual few, few side effects; 4. avoid the first pass effect of liver sausage.
Bolus of ten powerful tonics has had launch to sell at home, but in the practice, the weak point of bolus of ten powerful tonics is that preparation technology is outmoded, and dosage form is water-honeyed pill or honeyed pill, uses inconvenience, brings many troubles for the patient of old, children and dysphagia.The present invention adopts superfine communication technique and quick dispersion technology that the medicinal piece of shiquan dabu pill is transformed, transformation process has overcome the difficulty that Chinese medicine preparation faces in the modified form process, the difficulty of particularly using superfine communication technique and quick these new technique aspects of dispersion technology to face, grope through screening and technology, under the constant situation of Chinese medicine preparation, prepared a kind of solid preparation similar to the bolus of ten powerful tonics effect with quick disintegration properties.
Summary of the invention
The invention provides a kind of superfine communication technique and quick dispersion technology in conjunction with the new technique that is used for Chinese patent medicine, the quick dispersible preparation of particularly making in conjunction with the technology of preparing of Chinese patent medicine bolus of ten powerful tonics similar to the bolus of ten powerful tonics effect obtained beyond thought effect.
Quick dispersible preparation of the present invention be with the Chinese medicine principal agent through after pulverizing and/or extracting processing, with at least a disintegrating agent with meet water to form full-bodied swelling adjuvant formulated, said preparation is met water disintegrate and form uniform viscosity suspension rapidly.
The quick dispersible preparation of the present invention, the prescription of its Chinese medicine part is composed as follows:
40 parts～160 parts of Radix Codonopsis, 40 parts～160 parts of the Rhizoma Atractylodis Macrocephalaes, 40 parts～160 parts in Poria, 20 parts～80 parts of Radix Glycyrrhizae Preparatas, 60 parts～240 parts of Radix Angelicae Sinensis, 20 parts～80 parts of Rhizoma Chuanxiongs, 40 parts～160 parts of the Radix Paeoniae Albas (wine stir-fry), 60 parts～240 parts of Radix Rehmanniae Preparata, 40 parts～160 parts of Radix Astragali Preparatas, 10 parts～40 parts of Cortex Cinnamomis.
Preferably:
80 parts of Radix Codonopsis, 80 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 80 parts in Poria, 40 parts of Radix Glycyrrhizae Preparatas, 120 parts of Radix Angelicae Sinensis, 40 parts of Rhizoma Chuanxiongs, 80 parts of the Radix Paeoniae Albas (wine stir-fry), 120 parts of Radix Rehmanniae Preparata, 80 parts of Radix Astragali Preparatas, 20 parts of Cortex Cinnamomis
More than form, part is a weight portion, calculates with crude drug, if with the gram is unit, can be made into 1000 agent medicine preparations, described 1000 doses of fingers, the final drug preparation of making, as make 1000 of capsule preparations, 1000 in tablet, granule 1000g, oral liquid 1000ml etc. also can make big packing as granule, as the 100-500 bag, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be a unit with milli part also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, and for especial patient, the proportioning of can corresponding adjustment forming increases or reduce being no more than 100%.
Single medicinal material, especially ministerial drug and adjuvant drug in more than forming also can be replaced by the suitable Chinese medicine with identical property of medicine, and its drug effect of the Chinese medicine preparation after the replacement is constant.
Its adjuvant of quick dispersible preparation of the present invention is significant to the present invention, and adjuvant of the present invention is selected from disintegrating agent, adhesive, suspending (thickening) agent, fluidizer, correctives, rectifys toner.Wherein suspending (thickening) agent, strong toner add according to the needs of preparation, if preparation does not need, just do not add.
The used adjuvant of the present invention obtains through screening, wherein disintegrating agent is selected from, super carboxymethyl starch sodium (upright collapsing), carboxymethyl starch sodium (CMS-Na), low-substituted hydroxypropyl cellulose (LS-HPC), crospolyvinylpyrrolidone (polyvinylpolypyrrolidone, PVPP), cross-linking sodium carboxymethyl cellulose (CCMC-Na, CCNa), low-substituted hydroxypropyl cellulose (LHPC) etc.For the less starch of swellbility, microcrystalline Cellulose etc. can guarantee the quick disintegrate of preparation (also can use under＜3min) the situation, but preferably swellbility greater than the disintegrating agent of 5ml/g.Adhesive is selected from polyvidone (PVP), for hyprolose sodium (HPMC); Suspending agent is selected from xanthan gum, Ka Baimu (CARBOMER), HPMC, melon glue.Fluidizer is selected from micropowder silica gel, Pulvis Talci, magnesium stearate.Correctives is selected from various essence, as Apis essence, green tea essence, Fructus Citri tangerinae essence, Fructus Citri Limoniae essence, flavoring pineapple essence, grape essence etc.Strong toner is any pharmaceutically useful pigment or makes the final user mode of preparation present the coloring matter that meets medicinal standard of certain color state.
The present invention also provides the preparation method of quick dispersible preparation of the present invention, this preparation method comprises, Chinese medicine pulverizing medicinal materials and/or extraction with above proportioning, ground product or extract obtain product after drying, through micronizing, obtain medicinal powder or the extract powder of particle diameter less than 75 μ m, this powder is as active constituents of medicine, mixed in the proper ratio with adjuvant through micronizing, make quick dispersible preparation of the present invention with the preparation technique of galenic pharmacy routine.Chinese medicine pulverizing medicinal materials described in this method can be according to traditional method as the method in " Ministry of Public Health standard for traditional Chinese medicines ": above ten flavors, be ground into fine powder, sieve mixing.Described extraction can use decocting in water to extract, alcohol reflux, and ethanol percolation extracts, the decocting in water precipitate with ethanol extracts, in the multiple extracting method such as alcohol heavy extraction to boil water any one selects to use preferably above ten flavors as required, Radix Codonopsis, Radix Rehmanniae Preparata, Radix Astragali Preparata, Radix Glycyrrhizae Preparata, Poria decoct with water secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction, filter, filtrate is concentrated into the thick paste shape; Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, flood and carry out percolation after 24 hours as solvent with 60% ethanol, collect the liquid of filtering, and reclaim ethanol, and are concentrated into the thick paste shape; Cortex Cinnamomi is extracted volatile oil to most.Get the Radix Paeoniae Alba and be ground into fine powder, with above-mentioned thick paste mixing, drying.Spray adds Oleum Cinnamomi, and mixing obtains.In order to provide preparation good quick dispersive ability, need the granularity of strict control active constituents of medicine and adjuvant, just grain diameter is little.Therefore, the process characteristic of preparation of the present invention is, before the preparations shaping active constituents of medicine and adjuvant is all carried out micronization; Its objective is the wettability that increases the powder particle surface, promote the medicine stripping.The present invention adopts the method for micronizing, obtains Chinese medicine medicinal powder or the Chinese medicine extract of particle diameter less than 75 μ m, then with particle diameter quite or the littler adjuvant of making pharmaceutical preparation mixed evenly, preparations shaping.For tablet, can adopt powder straight forming, wet granulation molding or dry granulation molding to prepare.
Superfine communication technique of the present invention, principal agent of the present invention and adjuvant are processed into particle diameter less than 75 μ m by existing superfine grinding method, are preferably less than 30 μ m, most preferably be micro powder granule less than 10 μ m, at present, micronization technology has two kinds of chemical method and Mechanical Method.Chemical synthesis can make micron order, submicron order even nano level powder body.The mechanical crushing method cost is low, output is big, be the preparation ultrafine powder main means, now large-scale application in commercial production.Micronizing can be divided into dry pulverization process and waterproof pulverization: different according to the principle that produces crush force in the crushing process, dry pulverization process has several forms such as air-flowing type, dither formula, screw (rod) mill formula, paddle type mill and Self-milling; Waterproof pulverization mainly is colloid mill and homogenizer.The present invention can obtain the product of particle diameter less than 75 μ m by above arbitrary method, preferably uses air-flow dry powder comminuting method.
Therefore, the disintegrating agent of the present invention in material principal agent of guaranteeing to use and adjuvant, adhesive, suspending (thickening) agent, fluidizer, correctives, to rectify toner etc. evenly mixed under all having less than the situation of 75 μ m particle diameters, the preparation solid preparation; Said preparation also has the high dispersive characteristic when being beneficial to absorption, can better absorb, and can take with solid form, also can add to take after making preparation be distributed in the liquid behind the liquid when taking.
Quick dispersible preparation of the present invention, the ratio of its principal agent and adjuvant are 100: 1～600, and wherein the ratio of principal agent and disintegrating agent is 100: 10～500.
Quick dispersible preparation of the present invention includes but not limited to fast disintegrating tablet as oral cavity disintegration tablet, and it can directly place the oral cavity, disperses by saliva, and disintegrate rapidly, no grittiness, good mouthfeel are beneficial to and swallow in the oral cavity.
The weight proportion of principal agent of the present invention and adjuvant is preferably following proportioning:
Principal agent 50-200 part
Disintegrating agent, 10-500 part
Adhesive, 1-10 part
Suspending (thickening) agent, 0-10 part
Fluidizer, 0.5-5 part
Correctives, 0-2 part
Rectify toner.0-2 part
Wherein, preferred disintegrating agent is super carboxymethyl starch sodium (upright collapsing), carboxymethyl starch sodium (CMS-Na), microcrystalline Cellulose.Preferred adhesive is selected from polyvidone (PVP), for hyprolose sodium (HPMC).Preferred fluidizer is micropowder silica gel.Preferred correctives is Fructus Citri Limoniae essence, grape essence.
Most preferred prescription composition of the present invention is listed in the embodiment of the invention.
Quick dispersible preparation of the present invention, its Chinese medicine preparation is identical with bolus of ten powerful tonics, and patent medicine has the temperature compensation QI and blood.Be used for QI and blood deficiency, pale complexion, the cardiopalmus of breathing hard, dizzy spontaneous perspiration, fatigue and asthenia, extremity are not warm, menorrhagia.Medicine in the embodiment of the invention has been carried out experimentation, proved that quick dispersible preparation of the present invention is better than the conventional formulation bolus of ten powerful tonics on curative effect, can reach the effect of conventional medicament, more obtained patient's welcome in the use with littler dosage.
The invention has the advantages that: the present invention is on the basis of the bolus of ten powerful tonics prescription of determined curative effect and preparation process, adopt vanguard technology technology such as superfine communication technique, increased the dispersion of medical material effectively, and use quickly disintegrated adjuvant, make preparation have the feature of quick dispersion and very big degree of scatter simultaneously, thereby it is convenient that the more former dosage form of medicine is taken, by quick disintegrate (＜3min) reach the purpose that improves bioavailability.Can put into when dispersible tablet uses and take after water disperses, or directly place mouth, become liquid apace, and for this series products of medicinal piece of shiquan dabu pill, be particularly suitable for making preparation of the present invention, can solve as dysphagia person (especially old man), or the patient's medication problem under the special environment that can not obtain water, provide a great convenience, and carry more convenient.Wherein particle diameter less than the medicinal powder of 75 μ m or the extract powder adjuvant identical or littler with particle diameter mixed be key factor of the present invention.
Outside the requirement to corresponding drug standard of the quality evaluation of quickly disintegrated solid preparation and official preparation general rule, preparation disintegration time high spot reviews content, disintegration time＜3min.
It has taking convenience, it is fast to absorb, bioavailability is high and untoward reaction is few, and the patient who is particularly suitable for old man and dysphagia takes, and can characteristics such as produce with conventional tablet production technology and equipment, is a kind of good novel form.
The specific embodiment
With specific embodiment the present invention is elaborated below.Bolus of ten powerful tonics dispersible tablet of the present invention, and the solid preparation with quick disintegrate feature of the side of deriving is to make by the represented method of following embodiment, involved method is the technological means that those skilled in the art can grasp and use.Following examples are implementation example of the present invention, and the part embodiment for claim of the present invention should not be construed as the restriction to claim of the present invention of going up in all senses.
Embodiment 1
Radix Codonopsis 80g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 80g, Poria 80g, Radix Glycyrrhizae Preparata 40g, Radix Angelicae Sinensis 120g, Rhizoma Chuanxiong 40g, the Radix Paeoniae Alba (wine stir-fry) 80g, Radix Rehmanniae Preparata 120g, Radix Astragali Preparata 80g, Cortex Cinnamomi 20g etc., its preparation method is: above ten flavors are mixed, micronizing, cross 400 orders, per 100 parts of powder and adjuvant are evenly mixed, the back tabletting of granulating, with Xin Feier coating material package clothing, promptly.See Table 1:
Table 1 preparation prescription and main evaluation result thereof
| The principal agent amount 1 | Disintegrating agent/consumption | Adhesive/consumption | Fluidizer/consumption | Other 2 | Disintegration time/min | |
| Prescription 1 prescription 2 prescriptions 3 prescriptions 4 prescriptions 5 | 100 100 100 100 100 | CMS-Na/10 CMS-Na/50 CMS-Na/90 CMS-Na/200 CMS-Na/500 | PVP/3 PVP/3 PVP/3 PVP/4 PVP/5 | Differential silica gel/1 differential silica gel/1 differential silica gel/1 differential silica gel/1 differential silica gel/1 | 1 1 1 1 1 | 2.6 0.9 0.5 0.4 0.3 |
Annotate: (1) is 100 parts with the principal agent amount, and other supplementary product consumption is a relative quantity, umber.Other is the tender agent etc. of distinguishing the flavor of (down together) (2).(down together)
Embodiment 2
Get Semen Platycladi 200g, Radix Ephedrae (processed with honey) 100g, Pinellia leaven (stir-fry) 200g, Radix Codonopsis 100g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 100g, Concha Ostreae (forging) 100g, Testa Tritici (parching to brown) 50g, Fructus Schisandrae Chinensis (system) 100g, Fructus Jujubae 300g slightly fries the little stir-fry of Removing Kernel for Date with Semen Platycladi, Fructus Schisandrae Chinensis earlier, mixed with seven flavors such as the Rhizoma Pinelliae then, micronizing is crossed 400 orders, sieve, mixing, per 100 parts of powder and adjuvant are evenly mixed, tabletting after granulating is with Xin Feier coating material package clothing, promptly.。See Table 2:
Table 2 preparation prescription and main evaluation result thereof
| The principal agent amount | Disintegrating agent/consumption | Disintegration time/min | |
| Prescription 1 prescription 2 | 100 100 | Upright collapsing/100 are upright to collapse/and 50 | 0.6 1.1 |
Embodiment 3
Get Semen Platycladi 200g, Radix Ephedrae (processed with honey) 100g, Pinellia leaven (stir-fry) 200g, Radix Codonopsis 100g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 100g, Concha Ostreae (forging) 100g, Testa Tritici (parching to brown) 50g, Fructus Schisandrae Chinensis (system) 100g, Fructus Jujubae 300g slightly fries Semen Platycladi, Fructus Schisandrae Chinensis earlier, and the little stir-fry of Removing Kernel for Date is mixed with seven flavors such as the Rhizoma Pinelliae then, decoct with water secondary, 10 times, 8 times, each 2 hours, collecting decoction, filter, the filtrate concentrate drying is pulverized, and crosses 300 orders, per 100 parts of powder and adjuvant are evenly mixed, the back tabletting of granulating, promptly.See Table 3:
Table 3 preparation prescription and main evaluation result thereof
| The principal agent amount | Disintegrating agent/consumption | Adhesive/consumption | Fluidizer/consumption | Other | Disintegration time/min |
| 100 | Microcrystalline Cellulose/90 | HPMC/3 | Differential silica gel/1 | 1 | 0.5 |
Claims (10)
1, a kind of perfect major supple mentation fast dispersion solid preparation, make by following Chinese medicine raw materials by weight proportion, 40 parts～160 parts of Radix Codonopsis, 40 parts～160 parts of the Rhizoma Atractylodis Macrocephalaes, 40 parts～160 parts in Poria, 20 parts～80 parts of Radix Glycyrrhizae Preparatas, 60 parts～240 parts of Radix Angelicae Sinensis, 20 parts～80 parts of Rhizoma Chuanxiongs, 40 parts～160 parts of the Radix Paeoniae Albas (wine stir-fry), 60 parts～240 parts of Radix Rehmanniae Preparata, 40 parts～160 parts of Radix Astragali Preparatas, 10 parts～40 parts of Cortex Cinnamomis is characterized in that, described fast dispersion solid medicine is after above-mentioned Chinese medicine is pulverized or extracted, carry out micronizing, obtain principal agent, this principal agent be selected from disintegrating agent, adhesive, suspending agent, fluidizer, correctives, the adjuvant of rectifying toner mixes, make preparation with the galenic pharmacy routine techniques, wherein the granularity of principal agent that all uses and adjuvant is all less than 75 μ m particle diameters.
2, fast dispersion solid medicine according to claim 1, make by following Chinese medicine raw materials by weight proportion, 80 parts of Radix Codonopsis, 80 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 80 parts in Poria, 40 parts of Radix Glycyrrhizae Preparatas, 120 parts of Radix Angelicae Sinensis, 40 parts of Rhizoma Chuanxiongs, 80 parts of the Radix Paeoniae Albas (wine stir-fry), 120 parts of Radix Rehmanniae Preparata, 80 parts of Radix Astragali Preparatas, 20 parts of Cortex Cinnamomis is characterized in that, described fast dispersion solid medicine is after above-mentioned Chinese medicine is pulverized or extracted, carry out micronizing, obtain principal agent, this principal agent be selected from disintegrating agent, adhesive, suspending agent, fluidizer, correctives, the adjuvant of rectifying toner mixes, make preparation with the galenic pharmacy routine techniques, wherein the granularity of principal agent that all uses and adjuvant is all less than 75 μ m particle diameters.
3, the fast dispersion solid medicine of claim 1 is characterized in that, wherein the granularity of principal agent that all uses and adjuvant is all less than 30 μ m particle diameters.
4, the fast dispersion solid medicine of claim 1 is characterized in that, wherein the granularity of principal agent that all uses and adjuvant is all less than 10 μ m particle diameters.
5, the fast dispersion solid medicine of claim 1, it is characterized in that, wherein disintegrating agent is selected from, super carboxymethyl starch sodium, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, low-substituted hydroxypropyl cellulose, starch, microcrystalline Cellulose; Adhesive is selected from polyvidone, for hyprolose sodium; Suspending agent is selected from xanthan gum, Ka Baimu, HPMC, melon glue; Fluidizer is selected from differential silica gel, Pulvis Talci, magnesium stearate; Correctives is selected from various essence, and strong toner is any pharmaceutically useful pigment or makes the final user mode of preparation present the coloring matter that meets medicinal standard of certain color state.
6, the fast dispersion solid medicine of claim 1 is characterized in that, is tablet, and it is composed as follows:
Principal agent 50-200 part
Disintegrating agent, 10-500 part
Adhesive, 1-10 part
Suspending (thickening) agent, 0-10 part
Fluidizer, 0.5-5 part
Correctives, 0-2 part
Rectify toner.0-2 part.
7, the preparation method of the described fast dispersion solid medicine of claim 1 is characterized in that, the process following steps:
(1) get respectively distinguish the flavor of medical material or decoction pieces according to the Chinese medicine preparation in the claim 1, after pulverizing or extracting, carry out the micronizing of granularity less than 75 μ m particle diameters, standby;
(2) resulting micropowders identical or littler with particle diameter is selected from following adjuvant: disintegrating agent, adhesive, suspending agent, fluidizer, correctives or strong toner mix homogeneously are prepared into preparation.
8, preparation method according to claim 6, it is characterized in that, wherein disintegrating agent is selected from, super carboxymethyl starch sodium, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, low-substituted hydroxypropyl cellulose, starch, microcrystalline Cellulose; Adhesive is selected from polyvidone, for hyprolose sodium; Suspending agent is selected from xanthan gum, Ka Baimu, HPMC, melon glue; Fluidizer is selected from differential silica gel, Pulvis Talci, magnesium stearate; Correctives is selected from various essence, and strong toner is any pharmaceutically useful pigment or makes the final user mode of preparation present the coloring matter that meets medicinal standard of certain color state.
According to the described preparation method of claim 6, it is characterized in that 9, the ratio of principal agent and adjuvant is 100: 1～600 in the preparation, the ratio of principal agent and disintegrating agent is 100: 10～500 in the preparation.
According to the described preparation method of claim 6, it is characterized in that 10, described preparation is a tablet, adopt powder straight forming, wet granulation molding or dry granulation molding.
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| CN102552524A (en) * | 2012-01-11 | 2012-07-11 | 上海中医药大学附属普陀医院 | Traditional Chinese medicine composition for inhibiting residual tumor focus as well as preparation method and application thereof |
| CN103505714A (en) * | 2013-10-11 | 2014-01-15 | 孙丽 | Traditional Chinese medicine for treating palpitation with syndrome of heart-blood insufficiency |
| CN103566016A (en) * | 2012-07-26 | 2014-02-12 | 康美药业股份有限公司 | Ultrafine powder piece of prepared rehmannia root, and preparation method and use thereof |
| CN103655887A (en) * | 2012-09-01 | 2014-03-26 | 黄丽琴 | Chinese medicinal Chinese angelica-astragalus body-strengthening and immunity-enhancing powder and vaccine combination chicken raising technology |
| CN104013762A (en) * | 2014-06-26 | 2014-09-03 | 夏征梅 | Traditional Chinese medicine composition for treating menorrhagia |
| CN105214040A (en) * | 2015-10-14 | 2016-01-06 | 刘焰琼 | A kind of formula being used for the treatment of stream cold sweat |
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- 2005-12-23 CN CNB2005101323858A patent/CN100515393C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552524A (en) * | 2012-01-11 | 2012-07-11 | 上海中医药大学附属普陀医院 | Traditional Chinese medicine composition for inhibiting residual tumor focus as well as preparation method and application thereof |
| CN103566016A (en) * | 2012-07-26 | 2014-02-12 | 康美药业股份有限公司 | Ultrafine powder piece of prepared rehmannia root, and preparation method and use thereof |
| CN103566016B (en) * | 2012-07-26 | 2015-12-02 | 康美药业股份有限公司 | A kind of Radix Rehmanniae Preparata superfine powder decoction pieces and its production and use |
| CN103655887A (en) * | 2012-09-01 | 2014-03-26 | 黄丽琴 | Chinese medicinal Chinese angelica-astragalus body-strengthening and immunity-enhancing powder and vaccine combination chicken raising technology |
| CN103505714A (en) * | 2013-10-11 | 2014-01-15 | 孙丽 | Traditional Chinese medicine for treating palpitation with syndrome of heart-blood insufficiency |
| CN104013762A (en) * | 2014-06-26 | 2014-09-03 | 夏征梅 | Traditional Chinese medicine composition for treating menorrhagia |
| CN105214040A (en) * | 2015-10-14 | 2016-01-06 | 刘焰琼 | A kind of formula being used for the treatment of stream cold sweat |
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| Publication number | Publication date |
|---|---|
| CN100515393C (en) | 2009-07-22 |
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