CN103055024B - Fresh rehmannia powder for treating cancerous fever - Google Patents
Fresh rehmannia powder for treating cancerous fever Download PDFInfo
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Abstract
The invention relates to application of fresh rehmannia in preparation of a medicine for treating cancerous fever. The medicine is characterized by including fresh rehmannia. The fresh rehmannia powder for treating cancerous fever disclosed by the invention has the advantages of obvious effect of cancerous fever treatment and no side effect.
Description
Technical field
The present invention relates to medicine, particularly a kind of medicine of Radix Rehmanniae treatment cancer fever, belongs to medical art.
Background technology
Cancer fever refers to the noninfectious fever that tumor itself causes, and is one of advanced malignant tumor common sympton.Long-term fever can cause energy and physical demands, has a strong impact on the quality of life of patient, should give positive control.
Modern medicine can't control cancer fever at present completely, clinical in anti symptom treatment.As physical cooling method commonly uses alcohol bath, warm sponge bath, ice bag cooling etc.Drug therapy commonly uses Non-steroidanalgetic drug, glucocorticoid etc.The stimulation of the downward regulating action of the immunity that Non-steroidanalgetic drug mainly suppresses PGE2 to mediate and heat center reaches the effect of cooling; Hormone medicine is mainly by suppressing heat center to the reaction of pyrogen, and the release reducing endogenous pyrogen reduces body temperature.Antipyretic analgesic commonly uses indomethacin, diclofenac sodium, ibuprofen, aspirin etc.; Hormone has prednisone and dexamethasone etc.Western medicine cancer fever, rapid-action, but it is short to hold time, easily recurrence, side reaction are many, and treatment by Chinese herbs cancer fever have hold time long, not easily recur, feature that adverse reaction rate is low.When Western medicine control not good, invalid or patient base's situation difference cannot tolerate Western medicine side effect, according to conditions of patients, take determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs as principle, inside and outside and adjust, giving consideration to both the incidental and fundamental, can patients ' life quality be improved, extend life cycle.
Radix Rehmanniae is the fresh or dried root of scrophulariaceae rehmannia glutinosa plant (Rehmannia glutinosa Li-bosch).Autumn excavates, and except removing LU, fibrous root and silt, using fresh herb, practises and claim " Radix Rehmanniae ".It is slowly cured to eighty per cant dry, practise and claim " Radix Rehmanniae ".Get Radix Rehmanniae to stew to wine exhaustion according to stewed with wine method (" Chinese Pharmacopoeia " version appendix II D in 2010), take out, when dry in the sun is slightly dry to crust mucus; Or steam extremely black profit according to steaming method (" Chinese Pharmacopoeia " version appendix II D in 2010), and take out, shine to when about most probably doing, cut sheet or block, dry, obtain " Radix Rehmanniae Preparata ".The pharmacodynamic feature of these 3 kinds of Radix Rehmanniae is different, and Radix Rehmanniae has effect of clearing away heat and promoting production of body fluid, removing heat from blood, hemostasis; Radix Rehmanniae has the effect of clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting; The function that Radix Rehmanniae Preparata then has nourishing YIN and supplementing blood, beneficial essence fills out marrow.
The pharmacological research of Radix Rehmanniae receives and pays close attention to widely in recent years, and is widely used in clinical.For hemostasis, for diabetes, for cardiovascular and cerebrovascular disease, for hypertension, for nephritis, for dementia, for urinary system, for oral ulcer etc.
Radix Rehmanniae sweet-bitter flavor, property Great Cold, there is effect of clearing away heat and promoting production of body fluid, removing heat from blood, hemostasis, clinical in Radix Rehmanniae treatment otitis media, pharyngolaryngitis, arthritis, hepatitis, epistaxis, haematemesis.There is no the bibliographical information with Radix Rehmanniae treatment cancer fever at present.
Summary of the invention
The present invention is to provide with the application in Radix Rehmanniae preparation treatment cancer fever medicine.
Application in Radix Rehmanniae preparation treatment cancer fever medicine, feature is that described medicine contains Radix Rehmanniae.
Application in Radix Rehmanniae preparation treatment cancer fever medicine of the present invention, feature is described medicine is prepared by single delicious Radix Rehmanniae.
Application in Radix Rehmanniae preparation treatment cancer fever medicine of the present invention, feature is that described medicine is used for the treatment of extreme noxious heat cancer fever.
Application in Radix Rehmanniae preparation treatment cancer fever medicine of the present invention, feature is the pharmaceutical preparation of making, and patient's taking dose of a day is equivalent to fresh and dried Radix Rehmanniae 9-300g.
Application in Radix Rehmanniae of the present invention preparation treatment cancer fever medicine, feature is that Radix Rehmanniae is directly pulverized and taken or/and Radix Rehmanniae is squeezed the juice takes.
Application in Radix Rehmanniae preparation treatment cancer fever medicine of the present invention, feature is that Radix Rehmanniae is directly pulverized or/and Radix Rehmanniae is squeezed the juice, and makes preparation.
Application in Radix Rehmanniae of the present invention preparation treatment cancer fever medicine, feature be Radix Rehmanniae replace with Radix Rehmanniae extract or/and freeze dried fresh Radix Rehmanniae or/and Radix Rehmanniae is squeezed the juice dry thing or/and freeze dried fresh Radix Rehmanniae extract, make preparation.
Application in Radix Rehmanniae preparation treatment cancer fever medicine of the present invention, feature according to actual needs, can add other raw material of Chinese medicine further, make oral formulations.
Application in Radix Rehmanniae preparation treatment cancer fever medicine of the present invention, feature is can be according to actual needs, add in Radix Scutellariae, Cortex Phellodendri, Rhizoma Coptidis, Herba Taraxaci, Radix Trichosanthis, the Rhizoma Anemarrhenae, the Radix Rehmanniae, Cortex Moutan, Cornu Bubali, Herba Hedyotidis Diffusae further one or more, make preparation.
A kind of preparation method of the freeze dried fresh Radix Rehmanniae that the present invention is above-mentioned is: new Radix Rehmanniae, cleans roguing, is cut into segment; Sabot, loading amount is 5-8Kg/ about ㎡; Solidification point controls between-28 ~-32 DEG C; After reaching control temperature, open vacuum pump evacuation immediately to below drying chamber pressure 50Pa, then start heater switch, promote that distillation rises; The temperature of China should control below 40 DEG C; The temperature of resolution phase should control below 45 DEG C.
So far complete the present invention, medicine prepared by Radix Rehmanniae of the present invention, treatment cancer fever is evident in efficacy, has no side effect.The beneficial effect that the present invention treats cancer fever is set forth in following clinical trial further.
1, physical data: cancer patient 30 example, wherein male 17 example, women 13 example; Age is between 30-75 year.Wherein primary hepatocarcinoma 6 example, pulmonary carcinoma 7 example, gastric cancer 7 example, malignant lymphoma 8 example, breast carcinoma 2 example.
2, clinical symptoms: all cases heating all between 37.3-38.5 DEG C, and gets rid of the heating caused by other reason.
3, Therapeutic Method: take lyophilizing fresh rehmannia powder of the present invention, each 9g, every day 3 times 1 week is 1 course for the treatment of.
4, therapeutic outcome: after 1 course for the treatment of of taking medicine, statistics curative effect, it is effective that (body temperature is down to less than 37.2 DEG C, and no longer raise in drug withdrawal 1 week) 19 examples, effectively (be down to 37.2 ~ 37.5 DEG C) 10 example, invalid (period in a medicine body temperature do not decline or during medication temperature decline and within the observation period go up) 1 example, total effective rate 96.6%.In effective case, body temperature is down to the fastest normal person 2 hours, the slowest person about 2 days, average 1.5 days.
Detailed description of the invention
Embodiment 1
Adopt ZG-100 ㎡ type vacuum freeze drier.Choose Radix Rehmanniae, clean roguing, sabot, sabot weight is 7kg/ ㎡, lowers the temperature gradually after 2 hours and carries out pre-freeze to-28 DEG C; Then be evacuated to system absolute pressure 40Pa, start to be heated to 35 DEG C, sublimation drying 15 hours; Keep temperature of charge 35 DEG C again, when temperature of charge and heating-up temperature close to time dryly to terminate, take out pulverizing, obtain dry fresh rehmannia powder.
Add appropriate low-substituted hydroxypropyl cellulose, mixing, wet granulation, dry, add appropriate Pulvis Talci, mixing, tabletting, obtains tablet, and every sheet is containing dry fresh rehmannia powder 0.4g.Be used for the treatment of the patient of cancer fever, each 5, every day 3 times.
Embodiment 2
Get freeze dried fresh Radix Rehmanniae 3kg, flood 7 days with alcohol at normal temperature, reclaim ethanol, dry, pulverize, obtain freeze dried fresh Radix Rehmanniae extract.
Add carboxymethyl starch sodium, starch is appropriate, gelatinized corn starch is granulated, dry, arranges, and adds Pulvis Talci in right amount, mixing, tabletting.For the patient of cancer fever, divide and take for 10 days, every bu is taken for 3 times.
Embodiment 3
Get the test of Radix Rehmanniae 15g(drying and be equivalent to Radix Rehmanniae 3g), smash to pieces, oral, every day 3 times.Be used for the treatment of the patient of cancer fever.
Embodiment 4
Get Radix Rehmanniae 50g, smash to pieces, squeeze the juice, oral, every day 3 times.Be used for the treatment of the patient of cancer fever.
Embodiment 5
Get Radix Rehmanniae 15kg, pulverize, cross 80 mesh sieves, add arabic gum 0.5kg, sorbic acid 3g, obtain Radix Rehmanniae suspensoid.Oral, each 20ml, every day 3 times.Be used for the treatment of the patient of cancer fever.
Embodiment 6
Get Radix Rehmanniae 15kg, pulverize, squeeze the juice, add sorbic acid 2g, obtain Radix Rehmanniae oral liquid.Oral, each 15ml, every day 3 times.Be used for the treatment of the patient of cancer fever.
Embodiment 7
Get Radix Rehmanniae 15kg, pulverize, squeeze the juice, add lyophilizing fresh rehmannia powder 3kg, sorbic acid 2g, obtain Radix Rehmanniae suspensoid.Oral, each 15ml, every day 3 times.Be used for the treatment of the patient of cancer fever.
Embodiment 8
Get Radix Rehmanniae 15kg, pulverize, flood 7 days with alcohol at normal temperature, reclaim ethanol, dry, pulverize, obtain Radix Rehmanniae extract.
Add carboxymethyl starch sodium, starch is appropriate, gelatinized corn starch is granulated, dry, arranges, and adds Pulvis Talci in right amount, mixing, tabletting.For the patient of cancer fever, divide and take for 10 days, every bu is taken for 3 times.
Embodiment 9
Get freeze dried fresh Radix Rehmanniae 3kg, with ethanol percolation, percolate reclaims ethanol, adds the ground product of 3kg Radix Rehmanniae, dry, fully mixes with appropriate dextrin, granulates, dry, obtains granule 120 bags.
For the patient of excessive noxious heat cancer fever, each 1 bag, every day each 1 time sooner or later.
Embodiment 10
Get freeze dried fresh Radix Rehmanniae 3kg, with ethanol percolation, percolate reclaims ethanol, adds 3kg lyophilizing fresh rehmannia powder, dry, fully mixes with appropriate dextrin, granulates, dry, obtains granule 120 bags.
For the patient of cancer fever, each 1 bag, every day each 1 time sooner or later.
Embodiment 11
Get Radix Rehmanniae 15kg, pulverize, squeeze the juice, add 3kg freeze dried fresh Radix Rehmanniae extract, dry, mix with appropriate amount of auxiliary materials, granulate, encapsulated, obtain capsule.
For the patient of cancer fever, each 5, every day 3 times
Embodiment 12
Get Radix Rehmanniae 15kg, pulverize, flood 7 days with alcohol at normal temperature, reclaim ethanol, dry, pulverize, obtain Radix Rehmanniae extract.
Get Radix Scutellariae 12kg, Cortex Phellodendri 12kg, Rhizoma Coptidis 12kg, Herba Taraxaci 12kg, Radix Trichosanthis 6kg, Rhizoma Anemarrhenae 12kg, Radix Rehmanniae 12kg, Cortex Moutan 6kg, Cornu Bubali 6kg, Herba Hedyotidis Diffusae 12kg; Decoct with water twice, add water 1530L for the first time, decocts 1 hour, add water 1200L for the second time, decocts 1 hour, merges medicinal liquid, medicinal liquid filters, and get filtrate, being concentrated into relative density is 1.10(60 DEG C) time, adding ethanol makes alcohol content reach 50%, precipitation, leaves standstill 12 hours, Aspirate supernatant, reclaims ethanol, concentrated, dry, pulverize, get dry extract powder;
Radix Rehmanniae extract and dried cream powder and 0.3kg dextrin are fully mixed, wet granulation, dry, obtain granule.Be used for the treatment of the patient of cancer fever, each 1 bag, every day each 1 time sooner or later.
Embodiment 13
Get freeze dried fresh Radix Rehmanniae 5kg, pulverize, flood 7 days with alcohol at normal temperature, reclaim ethanol, dry, pulverize, obtain freeze dried fresh Radix Rehmanniae extract.
Get Radix Scutellariae 12kg, Herba Taraxaci 12kg, Cortex Moutan 6kg; Decoct with water twice, add water 1530L for the first time, decocts 1 hour, add water 1200L for the second time, decocts 1 hour, merges medicinal liquid, medicinal liquid filters, and get filtrate, being concentrated into relative density is 1.10(60 DEG C) time, adding ethanol makes alcohol content reach 50%, precipitation, leaves standstill 12 hours, Aspirate supernatant, reclaims ethanol, concentrated, dry, pulverize, get dry extract powder;
Freeze dried fresh Radix Rehmanniae extract and dried cream powder and 0.3kg dextrin are fully mixed, wet granulation, dry, obtain granule.Be used for the treatment of the patient of cancer fever, each 1 bag, every day each 1 time sooner or later.
Embodiment 14
Get Radix Rehmanniae 50g, smash to pieces, squeeze the juice, lyophilizing, obtain lyophilizing fresh rehmannia root juice.
Get Radix Trichosanthis 6kg, Rhizoma Anemarrhenae 12kg; Decoct with water twice, first time adds 10 times of water gagings, decocts 1 hour, second time adds 8 times of water gagings, decocts 1 hour, merges medicinal liquid, medicinal liquid filters, and get filtrate, being concentrated into relative density is 1.10(60 DEG C) time, adding ethanol makes alcohol content reach 50%, precipitation, leaves standstill 12 hours, Aspirate supernatant, reclaims ethanol, concentrated, dry, pulverize, get dry extract powder;
Lyophilizing fresh rehmannia root juice and dried cream powder and 0.3kg dextrin are fully mixed, wet granulation, dry, obtain granule.Be used for the treatment of the patient of cancer fever, each 1 bag, every day each 1 time sooner or later.
Claims (1)
1. treat a preparation method for the medicine of cancer fever, be characterised in that and prepared by following steps:
Get Radix Rehmanniae, clean roguing, sabot, sabot weight is 7kg/ ㎡, lowers the temperature gradually after 2 hours and carries out pre-freeze to-28 DEG C; Then be evacuated to system absolute pressure 40Pa, start to be heated to 35 DEG C, sublimation drying 15 hours; Keep temperature of charge 35 DEG C again, when temperature of charge and heating-up temperature close to time dryly to terminate, obtain freeze dried fresh Radix Rehmanniae;
Get freeze dried fresh Radix Rehmanniae 5kg, pulverize, flood 7 days with alcohol at normal temperature, reclaim ethanol, dry, pulverize, obtain freeze dried fresh Radix Rehmanniae extract;
Get Radix Scutellariae 12kg, Herba Taraxaci 12kg, Cortex Moutan 6kg; Decoct with water twice, add water 1530L for the first time, decocts 1 hour, add water 1200L for the second time, decocts 1 hour, merges medicinal liquid, medicinal liquid filters, and gets filtrate, when being concentrated into that relative density is 1.10 at the temperature of 60 DEG C, adding ethanol makes alcohol content reach 50%, precipitation, leaves standstill 12 hours, Aspirate supernatant, reclaims ethanol, concentrated, dry, pulverize, get dry extract powder;
Freeze dried fresh Radix Rehmanniae extract and dried cream powder and 0.3kg dextrin are fully mixed, wet granulation, dry, obtain granule.
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| CN104147222A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Preparation of raw rehmannia glutinosa and prepared rehmannia glutinosa through freezing method |
| CN104147225A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Freeze-dried rehmannia glutinosa used as high-bioavailability decocting pieces |
| CN104147221B (en) * | 2014-08-25 | 2017-02-01 | 济南康众医药科技开发有限公司 | Freeze-drying method of rehamnnia glutinosa |
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Non-Patent Citations (4)
| Title |
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| 中医辨证治疗癌性发热临床观察;李金彩等;《湖北中医杂志》;20071231;第29卷(第3期);第34页 * |
| 李佩文,李利亚主编.癌症病人吃什么.《癌症病人吃什么》.2005,第212页. * |
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Inventor after: Hua Mingyue Inventor before: Lu Ning Inventor before: Zhang Weisheng Inventor before: Xu Cuiping Inventor before: Li Shibiao Inventor before: Guo Meiying Inventor before: Xu Zhumei |
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Free format text: CORRECT: INVENTOR; FROM: LU NING ZHANG WEISHENG XU CUIPING LI SHIBIAO GUO MEIYING XU ZHUMEI TO: HUA MINGYUE |
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Address after: 250014 81 thousand Buddha Shandong Road, Lixia District, Ji'nan, Shandong Patentee after: Shandong Zhonghong Kang Pharmaceutical Technology Development Co Ltd Address before: 250014 No. 4, West building, Shandong Academy of Sciences, 19 Shandong Road, Lixia Road, Lixia District, Shandong Patentee before: Jinan Kangzhong Medicin Science & Technology Co., Ltd. |