CN101884735B

CN101884735B - Medicament for treating dyslipidemia and preparation method thereof

Info

Publication number: CN101884735B
Application number: CN2010102111072A
Authority: CN
Inventors: 潘根起
Original assignee: Individual
Current assignee: Individual
Priority date: 2010-06-28
Filing date: 2010-06-28
Publication date: 2012-04-18
Anticipated expiration: 2030-06-28
Also published as: CN101884735A

Abstract

The invention belongs to the technical field of traditional Chinese medicines, in particular relates to a medicament for treating dyslipidemia and a preparation method thereof. The medicament for treating the dyslipidemia is prepared from the following raw materials in part by weight: 2 to 15 parts of red paeony root, 2 to 15 parts of szechuan lovage rhizome, 2 to 15 parts of safflower, 5 to 20 parts of root of red-rooted salvia, 2 to 15 parts of notoginseng root, 2 to 15 parts of myrrh, 1 to 8 parts of scorpion, 2 to 15 parts of earthworm, 2 to 15 parts of tall gastrodia tuber, 1 to 8 parts of sanguisuga, 3 to 12 parts of tuber fleeceflower root, 1 to 6 parts of areca seed and 1 to 6 parts of rhubarb. The medicament for treating the dyslipidemia has the advantages of definite, stable and lasting curative effect and no toxic, side effect or adverse reactions.

Description

A kind of medicine of treating dyslipidemia and preparation method thereof

(1) technical field

The invention belongs to technical field of Chinese medicines, particularly a kind of medicine of treating dyslipidemia and preparation method thereof.

(2) background technology

Blood fat is a blood plasma lipide, comprises steroid hormone and the fatsoluble vitamin etc. of cholesterol (TC) and triglyceride (TG), fatty acid and phosphoric acid and trace.Blood fat mainly exists with the form with protein bound (being lipoprotein).Dyslipidemia disease refers to the blood plasma dyslipoproteinemia, comprising: the content and/or the component of blood fat are unusual.Clinically with high bile alcoholemia: TC＞5.2mmol/L (200mg/dL); Hypertriglyceridemia: TG＞1.7mmol/L (150mg/dL); High low density lipoprotein, LDL mass formed by blood stasis: LDL-C＞3.64mmol/L (140mg/dL) and high density lipoprotein-TC reduces: HDL-C＜0.91mmol/L (35mg/D1) is more to be seen.

Because people's income increases year by year, living standard progressively improves.The high protein that from diet, absorbs, hypercholesterolemia and high sugar food are more and more, add that labor intensity is more and more littler, and that eats is full, good absorbing, and the soup foot, movable few, thus cause dyslipidemia colony sharply to increase.The data investigation is arranged: serum cholesterol or triacylglycerol rising person account for 10-20% among the adult, even also have nearly 10% serum cholesterol or triacylglycerol to raise among the child.According to statistics in 2007, the ill total number of persons of dyslipidemia surpassed 90,000,000, and sickness rate is ascendant trend year by year, and dyslipidemia disease is the key factor of bringing out hypertension atherosclerosis, coronary heart disease, cerebrovascular, diabetes, fatty liver, obesity etc.

At present, the blood fat reducing Western medicine mainly contains four types: 1. fibrate, and this type of medicine has fenofibrate, gemfibrozil, bezafibrate etc., and their effect for reducing fat are strong, and are rapid-action, and the effect of triglyceride lowering is stronger than cholesterol reducing.2. trihydroxy methyl glutaryl CoA reductase inhibitor, as: simvastatin, lovastatin, pravastatin etc.; Their cholesterol reducing, effect for reducing fat are strong, rapid-action.3. nicotinic acid class: wherein acipimox is more commonly used; The effect of blood fat reducing triacylglycerol is stronger than cholesterol reducing.4. pantethine is the derivant of coenzyme A, and the effect of serum cholesterol-lowering, triacylglycerol and high density lipoprotein increasing-cholesterol is arranged.Though above medicine determined curative effect all has certain untoward reaction.The lighter can cause blood sugar increasing, feel sick abdominal distention, diarrhoea.Weight person causes hepatic and renal function injure, and very the person can cause rhabdomyolysis and death.To sum up, researching and developing safely and effectively, the blood lipid regulation medicine is very important.

(3) summary of the invention

The object of the present invention is to provide a kind of medicine of treating dyslipidemia, overcome the defective that there is untoward reaction in present similar medicine.

The technical scheme that the present invention adopts is following:

A kind of medicine of treating dyslipidemia, its raw material by following weight portion makes:

Radix Paeoniae Rubra 2-15 Rhizoma Chuanxiong 2-15 Flos Carthami 2-15 Radix Salviae Miltiorrhizae 5-20 Radix Notoginseng 2-15 Myrrha 2-15 Scorpio 1-8 Pheretima 2-15 Rhizoma Gastrodiae 2-15 Hirudo 1-8 Radix Polygoni Multiflori 3-12 Semen Arecae 1-6 Radix Et Rhizoma Rhei 1-6.

Further, said raw materials in part by weight is following:

Radix Paeoniae Rubra 5-10 Rhizoma Chuanxiong 5-10 Flos Carthami 5-10 Radix Salviae Miltiorrhizae 8-15 Radix Notoginseng 5-10 Myrrha 5-10 Scorpio 3-6 Pheretima 5-10 Rhizoma Gastrodiae 5-10 Hirudo 3-6 Radix Polygoni Multiflori 6-10 Semen Arecae 3-4 Radix Et Rhizoma Rhei 2-4.

The function of each composition is following in the raw material of the present invention:

Radix Paeoniae Rubra: merit with clearing away heat and cooling blood, stasis-dispelling and pain-killing.Research shows: Radix Paeoniae Rubra can significantly reduce serum cholesterol (TC), triglyceride (TG) and low density lipoprotein, LDL (LDL-C), and to not influence of high density lipoprotein (HDL-C).Have effect simultaneously, also have the memory function of improvement and cerebral protection simultaneously than more significantly blood fat reducing of nitrendipine, anti peroxidation of lipid, degraded plasma fibrinogen and anti-smooth muscle cell proliferation.

Rhizoma Chuanxiong: hot loose, temperature is logical, is " gas medicine in the blood ", can invigorate blood circulation and can circulation of qi promoting, can descend regulating menstruation water, middle relieving stagnation, the up head.The title of existing " gynecological's promoting blood flow to regulate menstruation key medicine " has not saying from Rhizoma Chuanxiong of headache again.Research shows: Rhizoma Chuanxiong contains the alkaloid ligustrazine, can suppress the contraction of vascular smooth muscle, coronary artery dilator, and coronary blood flow increasing improves myocardial oxygen consumption, increases brain and limb blood flow, reduces peripheral vascular resistance; Can reduce surface activity of blood platelet, anticoagulant can prevent the formation of thrombosis, and the effect of blood pressure lowering is arranged.

Flos Carthami: merit with promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.Research shows: Flos Carthami contains saffloside etc.; Saffloside can not only cholesterol reducing (TC), triglyceride (TG); And high density lipoprotein increasing 2C (HDL2-C), ApoA (AOP A) aspect also there is certain effect; Simultaneously can reduce apolipoprotein B (AOPB), be comparatively ideal fat regulation medicine.Can regulate the balance between plasminogen activator (t-PA) and the plasminogen activator mortifier (PAL) in addition, improve the fibrinous dissolving function of coronary heart disease, patient with angina pectoris, reduce thrombosis.

Radix Salviae Miltiorrhizae: merit with promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.Research shows: Radix Salviae Miltiorrhizae contains the water solublity danshensu; Has the effect that suppresses external thrombus formation and anticoagulant; Also have arteriosclerosis simultaneously, dwindle myocardial infarction area, expeirmental myocardial ischemia is had significant protection effect and antioxidation, anti-aging effects.

Radix Notoginseng: have dissipating blood stasis, hemostasis, the merit of subduing swelling and relieving pain.Research shows: Radix Notoginseng contains Radix Notoginseng total arasaponins, and it can obviously reduce serum total cholesterol (TC), triglyceride (TG) content.Blood pressure lowering is still arranged in addition, protect ischemic myocardium, improve unstable angina pectoris patient's left chamber diastolic function and to the protective effect of cranial nerve cell etc.

Myrrha: merit with promoting blood circulation and stopping pain.Research shows: Myrrha resinous (α and β heerabomyrrholic acid, α, β and γ myrrholic acid, commiphorinic acid, α and β heerabomyrrhol) has effect for reducing blood fat to male rabbit hypercholesterolemia, and can prevent that speckle from forming.

Scorpio: merit with relieving spasm by subduing liver-wind, removing obstruction in the collateral to relieve pain, dispersing pathogen accumulation.Research shows: Scorpio contains scorpion venom, the Neurotoxic protein of a kind of similar snake venom, and contain taurine, palmitic acid, stearic acid, cholesterol, lecithin and ammonium salt etc.Oral Scorpio preserved material and decoct all have remarkable persistent hypotensive effect, and clear-headed animal is had sedation, are usually used in the treatment of apoplexy and intractable headache.

Pheretima: have effects such as clearing away heat and relieving the wind syndrome, dredge the meridian passage.Research shows: LUMBRICUS tincture, dry powder suspension, hot dipping liquid, decoct etc. all have slow and persistent hypotensive effect etc.

Rhizoma Gastrodiae: merit with relieving spasm by subduing liver-wind, suppressing liver-YANG, dispelling wind and removing obstruction in the collateral.Research shows: the solid culture of armillaria mellea has pharmacological action similar with Rhizoma Gastrodiae and clinical efficacy.In recent years use armillaria mellea sheet treatment hyperlipemia, serum cholesterol, serum levels of triglyceride etc. are obviously descended, hypotensive effect is arranged simultaneously.

Hirudo: the merit of have removing blood stasis, stimulating the menstrual flow.Research shows: Hirudo contains hirudin and 17 seed amino acids.Also contain various trace elements such as Zn, Mn, Fe, Co, Cr, Se, Mo, Ni.Have that cholesterol reducing and prevention of arterial are atherosis, anticoagulant and thrombosis, increase myocardial nutrition property blood flow effect etc.

Radix Polygoni Multiflori: have effects such as loosening bowel to relieve constipation, detoxifcation, invigorating the liver and kidney, benefiting essence-blood, tranquilizing by nourishing the heart.Research shows: the extracting solution of Radix Polygoni Multiflori has cohesion between the platelet of reduction, the erythrocyte; Also weakened simultaneously the adsorptivity of both and blood vessel endothelium; Effectively avoid microthrombusis; Thereby strengthen platelet and erythrocytic function, promoting blood flow has positive role etc. to the atherosis cerebrovascular disease that waits of prevention of arterial.

Semen Arecae: effect with removing food stagnancy circulation of qi promoting.Semen Arecae contains arecoline, and it has the choline effect of intending, and excited cholinoceptor promotes saliva, and sweat gland secretion increases enterokinesia, decreasing heart rate, and effect such as bring high blood pressure down.

Radix Et Rhizoma Rhei: merit with purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Research shows: Radix Et Rhizoma Rhei contains rhubarb polyoses, anthraquinone class, catechin compounds, can reduce serum cholesterol (TC) and triglyceride (TG) and low density lipoprotein, LDL C (LDL-C), high density lipoprotein increasing C (HDL-C).Radix Et Rhizoma Rhei also contains emodin, and hypotensive effect is arranged.

" dyslipidemia " do not have this name of disease in motherland's medical science.Reason, pathogenic characteristic and the associated diseases that produces according to dyslipidemia can conclude that expectorant in motherland's medical science is turbid with it, in the blood stasis, carry out determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs.In clinical and experimentation, also confirmed dyslipidemia and the insubstantial phlegm that is stuck among the tissue such as meridians, and blocked in passages through which vital energy circulates, cause the not smooth blood stasis of blood fortune that quite similar part is arranged.The traditional Chinese medical science is thought many addiction to greasy and sweet foods of dyslipidemia patient savoury, and impairing the spleen and stomach causes fortuneization mistake department, and accumulatively wet raise phlegm is stagnated due to meridians and the internal organs; Or with hepatic and renal YIN deficiency, vehement in the asthenic fire, impairment of body fluid consumption liquid is prone to cause expectorant and coagulates meridians, and qi and blood stagnation is controlled suitable replenishing YIN and removing heat, disperse blood stasis and dredge collateral.

More than all medicine compatibilities have replenishing YIN and removing heat; Disperse blood stasis and dredge collateral and significant reduces serum cholesterol (TC), triglyceride (TG) and low density lipoprotein, LDL C (LDL-C), high density lipoprotein increasing C (HDL-C) and blood pressure lowering, and the prevention and the treatment of dyslipidemia, hypertension and cardiovascular diseases and cerebrovascular had significant curative effect.

Described crude drug can prepare the medicine of said treatment dyslipidemia by conventional method, and acceptable all dosage forms on the materia medica, preferably processes decoction or honeyed pill.

The present invention also further provides a kind of method that preferably is prepared into decoction or honeyed pill:

The method for preparing of the medicine decoction of treatment dyslipidemia is: get each raw material of said parts by weight, be incorporated as raw materials quality 5-8 water doubly, boil the back and use 20-40min at a simmer, get filtrating; Be incorporated as crude drug quality 4-6 water doubly once more, boil back reuse 20-30min at a simmer, get filtrating; The filtrating that merges twice promptly gets described decoction.

Preferably, after crude drug adds entry for the first time, soak 20-40min earlier and decoct again.

The method for preparing of the medicine honeyed pill of described treatment dyslipidemia is: said bulk drugs is pulverized the back cross 100 orders or 120 mesh sieves, again with medicated powder and sweet with 1: the mass ratio of 1.2-1.8 is processed honeyed pill.

Preferably, earlier with the honey heating, mix with medicated powder again behind the reddish yellow foam to occurring.

This Chinese medicine composition in use, anemia of pregnant woman and the patient forbidding of bleeding tendency is arranged both can use separately in clinical practice and also can join a spot of corresponding blood fat reducing class Western medicine, its determined curative effect, stable and lasting is not found other toxic and side effects.To be used effect better with a spot of corresponding blood fat reducing class Western medicine.

The present invention has following advantage with respect to prior art:

The present invention treats the medicine of dyslipidemia, and determined curative effect, stable, lasting is not seen toxic and side effects and untoward reaction.

(4) specific embodiment:

Below with specific embodiment technical scheme of the present invention is described, but protection scope of the present invention is not limited thereto:

Embodiment 1

A kind of medicine of treating dyslipidemia, its raw material by following weight portion (g) makes:

Radix Paeoniae Rubra 2 Rhizoma Chuanxiongs 2 Flos Carthamis 2 Radix Salviae Miltiorrhizaes 5 Radix Notoginseng 2 Myrrhas 2 Scorpios 1 Pheretima 2 Rhizoma Gastrodiaes 2 Hirudos 1 Radix Polygoni Multiflori 3 Semen Arecaes 1 Radix Et Rhizoma Rhei 1.

Medicine-feeding is gone in the marmite, add water 200m1, soak after 30 minutes; Used instead 20 minutes at a simmer after boiling with high heat earlier, filter out the about 150ml of medicinal liquid, second fries in shallow oil and adds water 180ml; After boiling with high heat earlier, use instead and filtered out medicinal liquid 140ml in 20 minutes at a simmer, fry in shallow oil gained medicinal liquid mixing two.

Embodiment 2

Radix Paeoniae Rubra 5 Rhizoma Chuanxiongs 5 Flos Carthamis 5 Radix Salviae Miltiorrhizaes 8 Radix Notoginseng 5 Myrrhas 5 Scorpios 3 Pheretimas 5 Rhizoma Gastrodiaes 5 Hirudos 3 Radix Polygoni Multiflori 6 Semen Arecaes 3 Radix Et Rhizoma Rhei 2.

Be decocted in water for oral dose: medicine-feeding is gone in the marmite, add water 400ml, soak after 30 minutes; Used instead 30 minutes at a simmer after boiling with high heat earlier, filter out the about 280ml of medicinal liquid, second fries in shallow oil and adds water 350ml; After boiling with high heat earlier, use instead and filtered out medicinal liquid 250ml in 25 minutes at a simmer, fry in shallow oil gained medicinal liquid mixing two.

Embodiment 3

Radix Paeoniae Rubra 7.5 Rhizoma Chuanxiongs 7.5 Flos Carthamis 7.5 Radix Salviae Miltiorrhizaes 11.5 Radix Notoginseng 7.5 Myrrhas 7.5 Scorpios 4.5 Pheretimas 7.5 Rhizoma Gastrodiaes 7.5 Hirudos 4.5 Radix Polygoni Multiflori 8 Semen Arecaes 3.5 Radix Et Rhizoma Rhei 3.

Medicine-feeding is gone in the marmite, add water 550ml, soak after 30 minutes; Used instead 30 minutes at a simmer after boiling with high heat earlier, filter out the about 300ml of medicinal liquid, second fries in shallow oil and adds water 500ml; After boiling with high heat earlier, use instead and filtered out medicinal liquid 300ml in 25 minutes at a simmer, divide 2 times after frying in shallow oil gained medicinal liquid mixing with two; Early, respectively obey decoction being taken warmly 1 time evening.

Embodiment 4

Radix Paeoniae Rubra 10 Rhizoma Chuanxiongs 10 Flos Carthamis 10 Radix Salviae Miltiorrhizaes 15 Radix Notoginseng 10 Myrrhas 10 Scorpios 6 Pheretimas 10 Rhizoma Gastrodiaes 10 Hirudos 6 Radix Polygoni Multiflori 10 Semen Arecaes 4 Radix Et Rhizoma Rhei 4.

To add medicine to pulverize after, cross 100 mesh sieves and obtain medicated powder, with medicated powder and the ratio of honey, honey be heated to occur stopping to heat behind the reddish yellow foam by 1: 1.5.With medicated powder in proportion with the sweet mix homogeneously that heats after, process honeyed pill, every ball 3g obeys the 1-2 ball at every turn, every day 3 times, warm boiled water.

Embodiment 5

Radix Paeoniae Rubra 15 Rhizoma Chuanxiongs 15 Flos Carthamis 15 Radix Salviae Miltiorrhizaes 20 Radix Notoginseng 15 Myrrhas 15 Scorpios 8 Pheretimas 15 Rhizoma Gastrodiaes 15 Hirudos 8 Radix Polygoni Multiflori 12 Semen Arecaes 6 Radix Et Rhizoma Rhei 6.

To add medicine to pulverize after, cross 100 mesh sieves and obtain medicated powder, with medicated powder and the ratio of honey, honey be heated to occur stopping to heat behind the reddish yellow foam by 1: 1.8.With medicated powder in proportion with the sweet mix homogeneously that heats after, process honeyed pill, every ball 3g obeys the 1-2 ball at every turn, every day 3 times, warm boiled water.

Clinical data

Case is selected and is divided into groups:

Select the patient of 172 routine dyslipidemia.Selected 172 routine dyslipidemia patients are outpatient service or inpatient.The selected the last fortnight of all patients was not all accepted treatment by Chinese herbs.Inclusion criteria:, measure through 3 times, on an empty stomach TC＞5.2mmol/L (200mg/dL) through diet control or the patient that takes the blood fat reducing Western medicine; TG＞1.7mmol/L (150mg/dL); LDL-C＞3.64mmol/L (140mg/dL) and HDL-C＜0.91mmol/L (35mg/dL), and it is bad not have hepatic and renal function.

Be divided into treatment group 86 example and matched group 86 examples at random.Wherein treatment group: male 59 examples, women 27 examples.Age 30-75 year, 51.5 years old mean age; Matched group 86 examples, wherein male 57 examples, women 29 examples, age 36-75 year, 52.7 years old mean age.Two groups are not all had significant difference (p＞0.05) at aspects such as sex, age and the state of an illness, have comparability.

Therapeutic Method:

Matched group is used Western medicine Statins or 3 weeks and 5 weeks of fibrate conventional therapy merely.If increasing with serum cholesterol (TC) is main person, use lipid-lowering statins; If increasing with serum levels of triglyceride (TG) is main person, with the special type medicine of shellfish.

The treatment group adds with 3 weeks and 5 weeks of this traditional Chinese medicine composition for treating on The control group Western medicine Statins or fibrate conventional therapy basis.Specifically can take according to the amount and the instructions of taking of the pill among the embodiment 4.

Observe: the change situation of serum cholesterol (TC), triglyceride (TG), low density lipoprotein, LDL (LDL-C) and high density lipoprotein (HDL-C) and clinical symptoms are improved situation.

Therapeutic evaluation

Efficacy assessment standard is published with reference to " adjusting hypolipidemic medicine clinical research guiding principle " and in December, 2006 Wang Jiyao chief editor, People's Health Publisher of Ministry of Public Health promulgation in 1988, supplies " internal medicine " of 7 years systems and specialty uses such as system clinical medicine in 8 years to draft.

Produce effects: TC decline >=50% or TG decline >=70% or LDL-C decline >=20% or HDL-C rising >=0.26mmol/L.

Effectively: TC decline 30%-49% or TG decline 50%-69% or LDL-C decline 10%-19% or HDL-C rising 0.01-0.25mmol/L.

Invalid: TC decline＜30% or TG decline＜50% or LDL-C decline＜10% or HDL-C rising＜0.01mmol/L.

Deterioration: rising >=10% of any one person: TC below near or TG rising >=10% or LDL-C rising >=5% or HDL-C decline >=0.1mmol/L.

Statistical procedures

Experimental data with

Expression is used in the SPSS6.0 software group and is compared between group, with paired t-test and x ²Check.With p＜0.05 is that difference has statistical significance.

The clinical practice result

Two groups of patients all accomplish 5 weeks of taking medicine, and do not have the person of dropping by the wayside.Lipid parameter ratio is seen table 1 before and after two groups of treatments, and clinical efficacy is relatively seen table 2 after two groups of 5 weeks of treatment.It is thus clear that this Chinese medicine composition cooperates Western medicine Statins or fibrate, the treatment dyslipidemia has evident in efficacy, and persistent is stable, does not see the characteristics of other toxic and side effects.

Table 1

(mmol/L，

)

Relatively preceding with treatment: ^1.P＜0.05 ^2.P＜0.01; Relatively, be p＜0.05. between two groups

Table 2

Untoward reaction:

When matched group was checked after 3 weeks of treatment or 5 weeks, there are 8 examples Glutamate pyruvate transaminase rises to occur, have 3 examples abdominal distention to occur and feel sick, promptly recover normal after the drug withdrawal.

The treatment group is in 3 weeks of treatment or 5 whens check week back, Glutamate pyruvate transaminase rises do not occur and other is unusual.

Model case:

Model case 1:

Ma, the man, 56 years old, the boss of restaurant suffered from " dizzy " on February 16th, 2008 and goes to a doctor.Patient's first quarter moon comes, because of being addicted to drink and savoury dizziness occurs and is nonrotary, heaviness of the head as being covered; Uncomfortable in chest nauseating, numbness, stiff tongue and retardation in speech are arranged during the brothers of left side, tongue is greasy in vain; Soft pulse is sliding, inspection: blood fat: cholesterol: 8.9mmol/l, triglyceride 9.6mmol/l; Low density lipoprotein, LDL 4.36mmol/l, high density lipoprotein 0.86mmol/l; Blood glucose: 18.6mmol/l; Blood pressure: 168/90mmHg; Heart rate: 78 times/minute; Breathe: 22 times/minute; Body temperature: 36.8 ℃.

Dialectical opinion is controlled: because of the addiction to greasy and sweet foods savoury, and impairing the spleen and stomach, fortuneization mistake department, causing wets to gather is disease, expectorant is turbid hoodwinks sun clearly, and sees dizziness, heaviness of the head as being covered.Stagnation of turbid phlegm in middle-JIAO, turbid YIN failing to descend, so disorder of QI movement is uncomfortable in chest nauseating.The turbid retardance meridian qi and blood of expectorant is then seen numb hand and foot, stiff tongue and retardation in speech, and tongue is greasy in vain, and the soft pulse cunning is the disease that expectorant accumulates in turbid.

Diagnosis: dizzy (stagnation of turbid phlegm in middle-JIAO)

The rule of treatment: removing dampness and eliminating phlegm, eliminating blood stasis and smoothing collaterals.

Side's medicine: the embodiment of the invention 5 prescriptions.

Usage: measure honeyed pill 3g/ ball, 1-2 ball/inferior, 3 times/day according to embodiment 4 accordingly.

Western medicine: the auxilliary enalapril of use of blood pressure regulation, blood sugar regulation are assisted with glipizide etc.

After 5 weeks of treatment, the patient is dizzy, and heaviness of the head as being covered and left side numb hand and foot fade away.TC, TG, LDL-C reduce to normally gradually, and HDL-C rises to BP:130/80mmHg normal range gradually, and blood glucose is basicly stable, reaches criterion of cure.When leaving hospital, advise the patient to give low fat, low sugar, higher-dimension diet at ordinary times, and note suitably taking exercise, and take the medicine of blood sugar control.Through repeatedly following up a case by regular visits to, still there is not recurrence so far.

Model case 2:

Platform so-and-so, the man, 48 years old, the driver went to a doctor because of suffering from cerebral thrombosis on June 25th, 2008.The patient before three days no obvious inducement to occur right side numb limbs and tense tendons activity suddenly unfavorable, slurred speech, mouthful eye is slightly crooked; The purplish tongue tongue is white, stringy and rolling pulse, blood fat: cholesterol 6.9mmol/l; Triglyceride 3.7mmol/l; LDL-C3.8mmol/l, HDL-C3.6mmol/l, head CT shows: the other softening kitchen range of ventriculus sinister cerebri.BP:150/90mmHg, P:78 time/minute, R:20 time/minute, T:37 ℃.

Dialectical Analyses: positive QI-insufficiency, venation is hollow, obstruction of collateral caused by windphlegm, numbness choke blood so numb limbs and tense tendons is movable unfavorable, is disturbed on the wind-phlegm, and meridians are become estranged, so slurred speech, mouthful eye is slightly crooked.Purplish tongue, tongue is white, and stringy and rolling pulse is the disease of stagnation of phlegm blood stasis.

Diagnosis: apoplexy (collaterals being void and defenceless, obstruction of collateral caused by windphlegm)

Method of treatment: expelling wind and activating blood circulation, eleminating phlegm and freeing channels.

Side's medicine: the embodiment of the invention 4 prescriptions.

Usage: honeyed pill 3g/ ball, 1 ball/inferior, 3 times/day.

General treatment: advise the patient to lie up, low fat diet, after 3 weeks of treatment, patient right side numb limbs and tense tendons, movable unfavorable recovery gradually is normal, and language is fluent gradually.TC, TG, LDL-C reduce to normal range gradually, and it is normal that HDL-C also recovers gradually, and BP:125/20mmHg reaches criterion of cure, advises its low fat light diet after leaving hospital, and notes suitably performing physical exercise, and through repeatedly following up a case by regular visits to, does not still have recurrence so far.

Allusion quotation example case 3:

Guo so-and-so, the man, 42 years old, the driver suffered from " dyslipidemia " on March 13rd, 2009 and goes to a doctor, the patient because of dizzy, tinnitus, headache and bloated appear in the delicious food of being addicted to drink, did not whenever aggravate with dizziness headache because of feelings will over 3 years.Flushed face, being irritable and getting angry easily, insomnia, dreaminess, purplish tongue, yellow fur, stringy pulse.Blood fat: cholesterol 5.6mmol/l, triglyceride 5.8mmol/l, low density lipoprotein, LDL 3.38mmol/l, high density lipoprotein 0.9mmol/l; Doppler shows: vertebra one basilar artery insufficiency.T:36.8 ℃; R; 20 times/day; P:76 time/minute; BP:155/100mmHg.

Dialectical Analyses: the delicious food of being addicted to drink, help humidogene heat, consumption of body fluid by heat causes the hepatic and renal YIN deficiency, excessive rising of liver-YANG, on emit and empty, so dizziness headache.Anger is impairing the liver then, and liver-yang is more contained, so the dizziness headache aggravation.Sun rises then flushed face, the then impetuous irritability of liver-yang hyperactivity.The liver-fire disturbance mind, then little sleep disturbed by dreams.Purplish tongue is dark, and yellow fur, stringy pulse are levying of excessive rising of liver-YANG.

Diagnosis: dizzy (excessive rising of liver-YANG)

The rule of treatment: suppressing the hyperactive liver and subsiding YANG, nourishing the liver and kidney.

Side's medicine: the embodiment of the invention 3 prescriptions.

Usage: according to the corresponding amount of embodiment 4 is 1 dose, and 1 dose of every day, decocting divides 2 times, early, respectively obey decoction being taken warmly evening 1 time.

After 3 weeks of treatment, the patient is dizzy, headache disappears, the sleep amelioration.Blood fat: cholesterol: 4.6mmol/l; Triglyceride: 1.7mmol/l; Low density lipoprotein, LDL: 2.8mmol/l; High density lipoprotein: 1.0mmol/l; BP:130/80mmHg; Reach criterion of cure.Advise the suitable light diet of patient when leaving hospital, note suitably taking exercise.Follow up a case by regular visits to through after half a year, review result is normal, does not have recurrence.

Model case 4:

Lee so-and-so, the woman, 59 years old, the peasant on May 16th, 2009, went to a doctor because of suffering from " dyslipidemia ".Patient no obvious inducement ground before 10 days occurs dizzy.The aggravation of movable back, lusterless complexion, nervous, insomnia, pale tongue, tongue is white, thready and weak pulse.Blood fat: cholesterol 8.27mmol/l; Triglyceride: 2.3mmol/l; Low density lipoprotein, LDL: 3.2mmol/l; High density lipoprotein: 1.21mmol/l; Doppler shows: vertebra one basilar artery insufficiency.BP：160/95mmHg.

Dialectical Analyses: the then clear sun of the deficiency of vital energy is not opened up venation block; Blood deficiency then brain become homeless foster, so dizzy meet the labor aggravation.Heart governing blood and vessels, its China is at face, and blood deficiency is lusterless complexion then, blood failing to tonify the heart, thus nervous, insomnia.Pale tongue, tongue is white, and thready and weak pulse is resembling of QI and blood deficiency.

Diagnosis: dizzy (deficiency of qi and blood)

Method of treatment: benefiting QI and nourishing blood, dredge the meridian passage.

Side's medicine: the embodiment of the invention 2 prescriptions.

After 3 weeks of treatment, the patient is dizzy, nervous disappearance, blood fat: cholesterol: 5.1mmol/l; Triglyceride: 1.0mmol/l; Low density lipoprotein, LDL: 2.6mmol/l; High density lipoprotein: 1.26mmol/l; BP:135/85mmHg. reach criterion of cure.Advise patient's low fat diet when leaving hospital, strengthen taking exercise, follow up a case by regular visits to check through after March, the blood fat result is normal, does not have recurrence.

Claims

1. medicine of treating dyslipidemia; It is characterized in that it is made by following bulk drugs: Radix Paeoniae Rubra 2-15 Rhizoma Chuanxiong 2-15 Flos Carthami 2-15 Radix Salviae Miltiorrhizae 5-20 Radix Notoginseng 2-15 Myrrha 2-15 Scorpio 1-8 Pheretima 2-15 Rhizoma Gastrodiae 2-15 Hirudo 1-8 Radix Polygoni Multiflori 3-12 Semen Arecae 1-6 Radix Et Rhizoma Rhei 1-6.

2. the medicine of treatment dyslipidemia as claimed in claim 1 is characterized in that, the parts by weight of said crude drug are following:

3. according to claim 1 or claim 2 the medicine of treatment dyslipidemia is characterized in that described crude drug is processed decoction or honeyed pill.

4. the method for preparing of the medicine of the described treatment dyslipidemia of one of claim 1-3; It is characterized in that described medicine is processed decoction: get each crude drug of said parts by weight, be incorporated as crude drug quality 5-8 water doubly; Boil the back and use 20-40min at a simmer, get filtrating; Be incorporated as crude drug quality 4-6 water doubly once more, boil back reuse 20-30min at a simmer, get filtrating; The filtrating that merges twice promptly gets described decoction.

5. the method for preparing of the medicine of treatment dyslipidemia as claimed in claim 4 is characterized in that, after crude drug adds entry for the first time, soaks 20-40min earlier and decocts.

6. the method for preparing of the medicine of the described treatment dyslipidemia of one of claim 1-3; It is characterized in that; Described medicine is processed honeyed pill: said bulk drugs is pulverized the back cross 100 orders or 120 mesh sieves, again with medicated powder and sweet with 1: the mass ratio of 1.2-1.8 is processed honeyed pill.

7. the method for preparing of the medicine of treatment dyslipidemia as claimed in claim 6 is characterized in that, earlier with the honey heating, mixes with medicated powder behind the reddish yellow foam to occurring again.