CN101979020B - Chinese medicinal preparation for treating high blood pressure - Google Patents
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Abstract
The invention relates to a pure Chinese medicinal composition, in particular to a Chinese medicinal preparation for treating high blood pressure. The Chinese medicinal preparation comprises the following raw medicaments in part by weight: 20 to 1,500 parts of Spanish needle herb, 30 to 1,200 parts of gambir plant, 30 to 1,200 parts of mountain green tea, 1 to 50 parts of eucommia bark, 10 to 130 parts of root of red rooted salvia, 10 to 150 parts of achyranthes root, 1 to 50 parts of cassia seed, 10 to 150 parts of kudzuvine root, 10 to 1,500 parts of Guangzhou hawthorn, 10 to 200 parts of oyster, 10 to 120 parts of magnetite, 10 to 150 parts of lotus leaf, 10 to 1,200 parts of keel and 10 to 1,200 parts of red ochre. The Chinese medicinal preparation can quickly and stably reduce blood pressure, change over the pathogenesis of the high blood pressure and solve the difficult problem of lifelong medicament administration of high blood pressure patients.
Description
Technical field
The present invention relates to a kind of pure Chinese medicine pharmaceutical composition, particularly a kind ofly be used to treat hypertensive Chinese medicine preparation.
Background technology
Hypertension is one of contemporary modal epidemic diseases, is the disease that a kind of serious harm health influences the human life quality.Someone likens the early high blood pressure disease become " noiseless killer ", makes people's vigilance because it unlike some disease, lets the people agonize earlier, and we often see unexpected apoplexy of somebody or myocardial infarction, just take leave of this world in an instant, and these major parts all are caused by hypertension.Hypertension also is the key factor of bringing out diseases such as heart failure, cerebral infarction, cerebral hemorrhage, renal failure.
What the treatment hypertension was commonly used at present is chemical medicine, mainly contains following several types: diuretic, β-receptor blocking agent, vasodilatin, chemical antihypertensive sheet and FUFANG JIANGYA PIAN etc.Acute attack has certain therapeutic effect to above conventional antihypertensive drugs to hypertension.Though chemical medicine effect rapidly in hypertensive therapeutic process; But side effect is also big; Obviously influence the metabolism of blood-fat and blood sugar etc.; Also possibly damage organs such as the heart, brain, kidney, the diseases such as damage of the hyperlipidemia that these medicines of while cause hypertension, high blood viscosity, target organ do not have tangible improvement effect.Take these depressor and cure the symptoms, not the disease, relapse rate almost is 100% after the drug withdrawal, and patient can only rely on Drug therapy throughout one's life.
Reach treating both the principal and secondary aspects of a disease; The little lasting medicine of toxic and side effects; Make the patient thoroughly away from the purpose of hypertension puzzlement, be difficult to reach through the therapeutic effect of clinical verification chemicals, and the Chinese medicine of China is having significant superiority than chemicals aspect the radical cure illness.Chinese patent medicine depressor commonly used has:
1, Bezoar pill for lowering blood pressure: contain the plurality of Chinese composition, but Calculus Bovis, Borneolum Syntheticum are all cold, so many imapirment of the spleen and stomach are not suitable for taking for a long time.
2, Zhenju Jiangya Tablet: compound preparation, multiple composition, synergism, Western medicine component consumption is few, and its side effect is to disturb the tubular excretion uric acid, causes hyperuricemia; Minority can be brought out the gout outbreak.Low density lipoprotein, LDL and triacylglycerol are raise, and high density lipoprotein reduces, and has to promote atherosclerotic possibility.
3, FUFANG LUOBUMA PIAN: blood pressure is obviously descended, but side effect is that borborygmus, diarrhoea are often arranged, idol has stomachache, xerostomia to wait bitterly for untoward reaction, and asthma, liver pain appear in individual patients; Cardiac toxicity mainly is bradycardia and premature beat.Excessive use can cause calmness, drowsiness, weak etc., can cause that also blood uric acid increases.
Though the Chinese medicine depressor of selling on the market at present is of a great variety; Take the interim blood pressure lowering in back but most medicines also are the patients, can not tackle the problem at its root, so be badly in need of the blood pressure lowering of a kind of ability quick and stable on the market; Need not take medicine for a long time, can better cure hypertensive medicine again.
Summary of the invention
The technical problem that the present invention will solve is: provide a kind of can be fast, steadily blood pressure lowering, reverse hypertension incidence mechanism, solve take medicine the throughout one's life hypertensive Chinese medicine preparation of treatment of difficult problem of hyperpietic, have problems to solve in the above-mentioned prior art.
The technical scheme that solves the problems of the technologies described above is: the hypertensive Chinese medicine preparation of a kind of treatment, and it comprises by following parts by weight proportion raw material medicine:
20～1500 parts of Herba Bidentis Bipinnatae, 30～1200 parts of Ramulus Uncariae Cum Uncis, 30～1200 parts of Folium Ilicis hainanensis,
1～50 part of the Cortex Eucommiae, 10～130 parts of Radix Salviae Miltiorrhizaes, 10～150 parts of Radix Achyranthis Bidentataes,
1～50 part of Semen Cassiae, 10～150 parts of Radix Puerariaes, 10～1500 parts of Fructus Crataegi,
10～200 parts of Concha Ostreaes, 10～120 parts of Magnetitums, 10～150 parts on Folium Nelumbinis,
10～1200 parts of Os Draconis, 10～1200 parts of Haematitums.
The hypertensive Chinese medicine preparation of described a kind of treatment, its raw material medicines in portions by weight is counted proportioning and is:
50～200 parts of Herba Bidentis Bipinnatae, 30～150 parts of Ramulus Uncariae Cum Uncis, 50～200 parts of Folium Ilicis hainanensis,
20～50 parts of the Cortexs Eucommiae, 10～60 parts of Radix Salviae Miltiorrhizaes, 10～40 parts of Radix Achyranthis Bidentataes,
10～50 parts of Semen Cassiaes, 10～30 parts of Radix Puerariaes, 30～180 parts of Fructus Crataegi,
10～60 parts of Concha Ostreaes, 10～60 parts of Magnetitums, 15～100 parts on Folium Nelumbinis,
20～150 parts of Os Draconis, 20～150 parts of Haematitums.
The hypertensive Chinese medicine preparation of described a kind of treatment, its raw material medicines in portions by weight is counted proportion optimization and is:
50 parts of Herba Bidentis Bipinnatae, 70 parts of Ramulus Uncariae Cum Uncis, 50 parts of Folium Ilicis hainanensis,
20 parts of the Cortexs Eucommiae, 30 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Achyranthis Bidentataes,
25 parts of Semen Cassiaes, 25 parts of Radix Puerariaes, 30 parts of Fructus Crataegi,
20 parts of Concha Ostreaes, 12 parts of Magnetitums, 30 parts on Folium Nelumbinis,
20 parts of Os Draconis, 20 parts of Haematitums.
The characteristic of various crude drug is following among the present invention:
Herba Bidentis Bipinnatae: function cures mainly: relieving the exterior syndrome heat clearing away, detoxifcation, dissipating blood stasis.
Meridian distribution of property and flavor: hardship, flat.
Ramulus Uncariae Cum Uncis: function cures mainly: heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion.
Meridian distribution of property and flavor: sweet, cold.Return liver, pericardium channel.
Folium Ilicis hainanensis: function cures mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain, blood circulation and channel invigorating.
Meridian distribution of property and flavor: bitter, sweet, flat.
The Cortex Eucommiae: function cures mainly: invigorating the liver and kidney, and bone and muscle strengthening, antiabortive.
Meridian distribution of property and flavor: sweet, temperature.Return liver, kidney channel.
Radix Salviae Miltiorrhizae: function cures mainly: stasis-dispelling and pain-killing, and promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.
Meridian distribution of property and flavor: hardship is slightly cold.GUIXIN, Liver Channel.
Radix Achyranthis Bidentatae: function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.
Meridian distribution of property and flavor: bitter, acid, flat.Return liver, kidney channel.
Semen Cassiae: function cures mainly: clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.
Meridian distribution of property and flavor: sweet, bitter, salty, be slightly cold.GUIXIN, spleen, lung meridian.
Radix Puerariae: function cures mainly: expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid rash, yang invigorating antidiarrheal.
Meridian distribution of property and flavor: sweet, hot, cool.Return spleen, stomach warp.
Fructus Crataegi: function cures mainly: regulating qi-flowing for strengthening spleen, dyspepsia and intestinal stasis relieving.
Meridian distribution of property and flavor: sweet, sour, puckery, tepor.Return spleen, stomach, Liver Channel.
Concha Ostreae: function cures mainly: tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.
Meridian distribution of property and flavor: salty, be slightly cold.Return liver, gallbladder, kidney channel.
Magnetitum: function cures mainly: suppressing the hyperactive liver and subsiding YANG, hearing-improing and eyesight improving, tranquillizing the mind by relieving convulsion, helping inspiration to relieve asthma.
Meridian distribution of property and flavor: salty, cold.Return liver, the heart, kidney channel.
Folium Nelumbinis: function cures mainly: clearing away summer-heat, sending up the lucid YANG, cooling blood for hemostasis.
Meridian distribution of property and flavor: hardship, flat.Return spleen, stomach, Liver Channel.
Os Draconis: function cures mainly: calm the nerves, and astringent or styptic treatment for spontaneous sweating; The external promoting tissue regeneration and ulcer healing.
Meridian distribution of property and flavor: flat.GUIXIN, liver, kidney, large intestine channel.
Haematitum: function cures mainly: suppressing the hyperactive liver and subsiding YANG, sending down the abnormal ascending QI, hemostasis.
Meridian distribution of property and flavor: bitter, cold.Return liver, heart channel.
Theory of Chinese medical science thinks that hypertension mainly is the imbalance of YIN and YANG by the heart, liver, renal function, adds exopathogen such as experiencing wind, heat, poison invasion and attack, hands over knot mutually with the intravital expectorant of people, the stasis of blood, and due to various factors interacts.Therefore, through suppressing the hyperactive liver and subsiding YANG, vital energy regualting and blood circulation-promoting, kidney is supported in YIN nourishing, and the heat clearing away blood stasis dispelling is the hypertensive effective way of treatment.In numerous medicines, the medicine of simple blood pressure lowering is not ideal medicine, and ideal medicine should be in blood pressure lowering, can reverse its pathological process, prevents and treats the generation of complication, and should not have obvious toxic and side effects.The present invention is based on above-mentioned theory, collects multiple rare Chinese medicine and utilizes modern technologies to develop.Its distinctive antihypertensive compositions can combine with the target cell of whole body blood vessel, organ, tissue, and the abnormal hemodynamics situation of body is corrected voluntarily.Pharmacodynamic study shows that hypertension pill has suppressing the hyperactive liver and subsiding YANG; Kidney is supported in YIN nourishing; Vital energy regualting and blood circulation-promoting, heat clearing away blood stasis dispelling, clear stagnating; Effects such as spasmolytic blood pressure lowering, capable of lowering blood pressure and decreasing blood fat, fall that blood is sticking, dizziness that vessel softening, blood lipid regulation, eliminating blood poison, treatment hypertension cause, headache, cardiopalmus, uncomfortable in chest, dim eyesight, tinnitus has unique curative effect.
The present invention takes through 200 multidigit patients, and effective percentage has reached 98%, cures the back and has not seen the phenomenon that recurrence is arranged at present.This product has unique curative effect and higher cure rate to treatment hypertension, and general patient only needed just can cure in 60 days, need not to take medicine for a long time no significant side effects.
The characteristics of these article:
1, these article can effectively eliminate the dizziness that causes by hypertension, cardiopalmus, uncomfortable in chest, breathe hard, have palpitation, weak, insomnia, ill symptoms such as forgetful, improve the uncomfortable situation of patient body rapidly, the raising patients ' life quality.
2, these article not only can be fast, steadily blood pressure lowering, improve the blood system allomeric function, can also thoroughly remove blood fat unnecessary in the blood and other noxious substance, thereby improve blood quality greatly, hypertension symptom promptly is controlled effectively.
3, can effectively repair the function damage of the heart that causes by hypertension, brain, kidney, make blood system recover self-regulating function, thoroughly reverse hypertension incidence mechanism, finally solve the difficult problem that the hyperpietic takes medicine throughout one's life from the cause of disease.Through patient's clinic trial, general patient takes medicine and can obtain recovery from illness in 60 days, breaks away from the predicament of taking depressor throughout one's life.
⑴ took the present invention 3-7 days, the dizziness that causes because of problems such as blood supplies, headache, insomnia, uncomfortable in chest, breathe hard, have palpitation etc. to have and slightly change the original sentence to, blood pressure descends to some extent.
⑵ took the present invention 10-15 days, and the blood supply problem continues to improve, and various malaise symptoms begin to alleviate, and blood pressure continues to improve.
⑶ took the present invention 20-30 days, and the blood supply problem is alleviated basically, and how various malaise symptoms disappear, but symptom slightly exists individually, and extremity are numb to be alleviated; The basic normal and stable of blood pressure, blood fat is normal or near normal value, atherosclerosis has bigger improvement, feels good.
⑷ took the present invention 30-60 days, blood supply problem and malaise symptoms complete obiteration, and sequela is improved and is begun to appear.The blood pressure normal equilibrium, blood fat is normal, and atherosclerosis is improved obviously, and the oneself is very comfortable, has much energy, and head is light.Can consider to begin to subtract the clothes antihypertensive drugs.
⑸ took the present invention 60 days-90 days, obstinate again hyperpietic, and also drug withdrawal fully, sequela is constantly improved, physical handicaps, recoveries such as aphasis, coronary heart disease is significantly improved.Reach the protection heart, brain, kidney, steadily blood pressure lowering, the complication complete obiteration.Be restored juvenescence people sensation of normal circulation of qi and blood, vigour, memory is improved, and does not feel tired.
Below, in conjunction with embodiment a kind of technical characterictic of treating hypertensive Chinese medicine preparation of the present invention is further described.
The specific embodiment
Embodiment one:
The hypertensive Chinese medicine preparation of a kind of treatment, it comprises by following parts by weight proportion raw material medicine:
Monarch drug Herba Bidentis Bipinnatae 50g, monarch drug Ramulus Uncariae Cum Uncis 70g, monarch drug Folium Ilicis hainanensis 50g,
Ministerial drug Cortex Eucommiae 20g, ministerial drug Radix Salviae Miltiorrhizae 30g, ministerial drug Radix Achyranthis Bidentatae 15g,
Ministerial drug Semen Cassiae 25g, ministerial drug Radix Puerariae 25g, ministerial drug Fructus Crataegi 30g,
Ministerial drug Concha Ostreae 20g, ministerial drug Magnetitum 12g, ministerial drug Folium Nelumbinis 30g,
Ministerial drug Os Draconis 20g, ministerial drug Haematitum 20g.
The method for preparing of above-mentioned Chinese medicine composition is:
A, get Radix Salviae Miltiorrhizae 5 g and be ground into fine powder;
B, remove Ramulus Uncariae Cum Uncis, the outer above 12 flavor medical materials of Semen Cassiae, decocte with water secondary, each 1.5 hours; Add for the first time 3.5 times of amounts of water, add 3 times of amounts of water for the second time, collecting decoction filters; To be concentrated into relative density be 1.24～1.26 (90 ℃) to filtrating, puts coldly, adds 4 times of amounts of water; Stir, left standstill 24 hours, getting supernatant concentration to relative density is 1.20～1.23 (80 ℃); Ramulus Uncariae Cum Uncis, Semen Cassiae added alcohol heating reflux 1.5 hours, and extracting solution filters, and filtrate recycling ethanol also is concentrated into an amount of.Above-mentioned 12 flavor medical material concentrated solutions and Ramulus Uncariae Cum Uncis, Semen Cassiae concentrated solution and an amount of adjuvant such as starch mix homogeneously are processed granule, drying.With Radix Salviae Miltiorrhizae fine powder and the above-mentioned granule mixing that steps A makes, compacting, the bag film-coat promptly gets hypertension pill.Also can be made into the ball shape or the Chinese medicine preparation of other form.
Embodiment two～embodiment five:
The hypertensive Chinese medicine preparation of a kind of treatment, the crude drug of said composition and parts by weight see also subordinate list one, and the method for preparing of this Chinese medicine composition is identical with embodiment one.
Through clinical trial case case curative effect of the present invention is described further below.
Patient 5 certain, woman, 49 years old, ill 18 years.The former western medicine of accepting for a long time; But dizziness, tinnitus, perspective view, extremity are aching and limp, numb, uncomfortable in chest, skin itching etc. must not be alleviated all the time, and course of treatment behind this kind medicine is used in the back, and the hypertension index obviously descends; The complication recovery that is eased; After three courses of treatment, can normally be engaged in work, production, lose recurrence more than a year at present.
2, patient Mr. Liu, the man, 53 years old, ill 9 years, engender recently and have a dizzy spell, sensation of oppression over the chest with shortness of breath, especially the whole body activity is often unable to do what one wishes.The blood pressure inspection is 180/120mmHg before using this medicine, and cholesterol and triglyceride in the serum obviously raise.Only medication is after 10 days, many transference cures such as dizziness and blurred vision, sensation of oppression over the chest with shortness of breath more than half, whole body energetically, spirit is obviously improved; Next serve on two the course of treatment medicine, all transference cures, electrocardiogram check; Blood supply of cardiac muscle is normal, and when paying a return visit in the recent period, he representes that blood pressure is normal.
3, patient Wu Xiansheng, man 44 years old, ill 5 years, to feel often to have palpitation, breathe hard, stomach is often latent painful, and some complication appear in heart and brain, medication repeatedly in the past few years, drug withdrawal all the time is bounce-back just.By the agency of has disposablely been bought three courses of treatment, returns to one's perfect health after having obeyed medicine, and all complication all disappear.
4, patient Qin Xiansheng, the man, 59 years old, nearly 16 years of hypertension, renal dysfunction 2 years is surplus, maximal blood pressure reaches 210/130mmHg, the time with headache, dizziness, take depressor, but controlling of blood pressure is undesirable.Take medicine a course of treatment, effectively expand blood vessels at different levels, blood pressure is reduced, fundamentally solved the continuation infringement of hypertension kidney.After treating 3 courses of treatment, the state of an illness all takes a turn for the better, and two lower limbs edema disappear, and nauseating, symptoms of emesis disappears, and diet increases, weak doing well,improving, and other transference cure, blood pressure is normal.
5, happy Mr. of patient, the man 61 years old, suffered from III phase hypertension 9 years; High pressure 190, low pressure 110, concurrent coronary heart disease; Often headache, insomnia, retinal hemorrhage took place in nearly 2 years again, audition also obviously descends, and various Chinese medicine and western medicine were all used; Blood pressure is fluctuated all the time, but also can control basically, is exactly can not drug withdrawal.Ordered this medicine of a course of treatment afterwards in advance, headache obviously alleviated than in the past, and blood pressure also no longer raises; Ordered three courses of treatment subsequently again, it is good more to obey spirit more, and blood pressure stabilization is between 140/90; Various complication also disappear thereupon, and drug withdrawal is not recurred so far.
6, patient Liu Nvshi, 42 years old, health check-up found to suffer from hypertension before 2 years, begins to think to have no; Sometimes have some depressor, low when high during blood pressure, aftersensation memory obviously descended in 1 year; Ophthalmic is pain often, to examination in hospital hypertension II type, introduces through friend; Take this medicine after three courses of treatment, all are normal for examination in hospital, do not have bounce-back so far.
Subordinate list one
Claims (2)
1. treat hypertensive Chinese medicine preparation for one kind, it is characterized in that: its crude drug is:
50～200 parts of Herba Bidentis Bipinnatae, 30～150 parts of Ramulus Uncariae Cum Uncis, 50～200 parts of Folium Ilicis hainanensis,
20～50 parts of the Cortexs Eucommiae, 10～60 parts of Radix Salviae Miltiorrhizaes, 10～40 parts of Radix Achyranthis Bidentataes,
10～50 parts of Semen Cassiaes, 10～30 parts of Radix Puerariaes, 30～180 parts of Fructus Crataegi,
10～60 parts of Concha Ostreaes, 10～60 parts of Magnetitums, 15～100 parts on Folium Nelumbinis,
20～150 parts of Os Draconis, 20～150 parts of Haematitums.
2. the hypertensive Chinese medicine preparation of a kind of treatment according to claim 1, it is characterized in that: its crude drug is:
50 parts of Herba Bidentis Bipinnatae, 70 parts of Ramulus Uncariae Cum Uncis, 50 parts of Folium Ilicis hainanensis,
20 parts of the Cortexs Eucommiae, 30 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Achyranthis Bidentataes,
25 parts of Semen Cassiaes, 25 parts of Radix Puerariaes, 30 parts of Fructus Crataegi,
20 parts of Concha Ostreaes, 12 parts of Magnetitums, 30 parts on Folium Nelumbinis,
20 parts of Os Draconis, 20 parts of Haematitums.
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| CN102940786B (en) * | 2012-10-10 | 2014-04-02 | 肥西县中医院 | Traditional Chinese medicine for treating hypertension |
| CN103191367A (en) * | 2013-03-11 | 2013-07-10 | 温志民 | Collateral dredging and blood pressure reducing capsules |
| CN103609771A (en) * | 2013-11-23 | 2014-03-05 | 王芬 | Antihypertensive healthcare tea |
| CN105028763A (en) * | 2015-07-14 | 2015-11-11 | 青岛华仁技术孵化器有限公司 | Pressure-reducing health tea |
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