CN110833594A - Medicine for treating cerebral infarction and preparation method thereof - Google Patents
Medicine for treating cerebral infarction and preparation method thereof Download PDFInfo
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- CN110833594A CN110833594A CN201911096338.0A CN201911096338A CN110833594A CN 110833594 A CN110833594 A CN 110833594A CN 201911096338 A CN201911096338 A CN 201911096338A CN 110833594 A CN110833594 A CN 110833594A
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- 239000003814 drug Substances 0.000 title claims abstract description 33
- 206010008118 cerebral infarction Diseases 0.000 title claims abstract description 26
- 208000026106 cerebrovascular disease Diseases 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 229940079593 drug Drugs 0.000 title claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000002994 raw material Substances 0.000 claims abstract description 17
- 238000009835 boiling Methods 0.000 claims abstract description 12
- 241000382455 Angelica sinensis Species 0.000 claims abstract description 8
- 241000045403 Astragalus propinquus Species 0.000 claims abstract description 8
- 241000112528 Ligusticum striatum Species 0.000 claims abstract description 8
- 244000131316 Panax pseudoginseng Species 0.000 claims abstract description 8
- 235000003181 Panax pseudoginseng Nutrition 0.000 claims abstract description 8
- 241000304195 Salvia miltiorrhiza Species 0.000 claims abstract description 8
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims abstract description 8
- 235000006533 astragalus Nutrition 0.000 claims abstract description 8
- 241000305491 Gastrodia elata Species 0.000 claims abstract description 3
- 238000012216 screening Methods 0.000 claims description 5
- 241000213006 Angelica dahurica Species 0.000 claims description 3
- 238000005070 sampling Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 16
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses a medicament for treating cerebral infarction and a preparation method thereof, wherein the medicament comprises the following raw materials in parts by weight: 28-32 parts of rhizoma polygonati, 18-22 parts of astragalus mongholicus, 35-45 parts of radix angelicae, 18-22 parts of salvia miltiorrhiza, 18-22 parts of pseudo-ginseng, 18-22 parts of gastrodia elata, 13-17 parts of radix saposhnikoviae, 13-17 parts of angelica sinensis and 13-17 parts of ligusticum wallichii. The preparation method comprises adding water 7-9 times the total weight of all the raw materials, boiling with strong fire, decocting with slow fire for 25-35min, and collecting decoction; adding water 5-7 times the total weight of the residue, boiling with strong fire, decocting with slow fire for 20-30min, mixing the two water decoctions, and mixing. The medicine for treating the cerebral infarction has the advantages of quick response, good curative effect, no toxic or side effect and convenience and quickness in administration.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a medicine for treating cerebral infarction and a preparation method thereof.
Background
Cerebral infarction, also known as cerebral infarction (ischemic stroke), is the ischemic necrosis or softening of localized brain tissue caused by cerebral blood supply disorder, ischemia, and hypoxia. Common clinical types of cerebral infarction include cerebral thrombosis, lacunar infarction, cerebral embolism and the like, and the cerebral infarction accounts for 80% of all cerebral apoplexy. Diseases closely related to it are: diabetes, obesity, hypertension, rheumatic heart disease, arrhythmia, dehydration due to various reasons, arteritis, shock, and excessive blood pressure drop. The clinical manifestations are characterized by sudden syncope, unconsciousness, hemiplegia, speech disturbance and intellectual disturbance. Cerebral infarction not only poses great threat to human health and life, but also brings great pain and heavy burden to patients, families and society.
Cerebral infarction, a sudden brain disease, can occur at any age, and the degree of necrosis varies depending on the location and size of the thrombus. It is common in the middle aged and the elderly of 45-70 years old. The attack is acute, no prodromal symptoms exist, the focal nerve sign reaches the peak within minutes to hours, complete stroke is frequently shown, consciousness is clear or mild consciousness disturbance is caused, the main embolism of the internal carotid artery or the middle cerebral artery causes large-area cerebral infarction, severe cerebral edema, intracranial pressure is increased, even cerebral hernia and coma occur, and epileptic attack is rarely seen; coma frequently occurs in the vertebral-basilar arterial system embolism, and the focal characteristics of individual cases are stable or aggravated after the first improvement, which prompts the recurrence of infarction or secondary bleeding, and the like.
At present, the cerebral infarction is mainly treated by western medicine treatment, including surgical operation treatment, embolism is eliminated by physical trauma or chemical means, the unblocked blood vessels are recovered, or overflowing blood stasis is eliminated, and the like, so that the cerebral infarction has large toxic and side effects and high risk. At present, the Chinese patent medicines for treating cerebral infarction in the market are also few.
Disclosure of Invention
The invention aims to provide a medicament for treating cerebral infarction, which has the advantages of quick response, good curative effect and no toxic or side effect.
The invention also aims to provide a preparation method of the medicine.
The invention relates to a medicament for treating cerebral infarction, which comprises the following raw materials in parts by weight:
28-32 parts of rhizoma polygonati, 18-22 parts of astragalus mongholicus, 35-45 parts of radix angelicae, 18-22 parts of salvia miltiorrhiza, 18-22 parts of pseudo-ginseng, 18-22 parts of gastrodia elata, 13-17 parts of radix saposhnikoviae, 13-17 parts of angelica sinensis and 13-17 parts of ligusticum wallichii.
The medicine for treating cerebral infarction is preferably prepared from the following raw materials in parts by weight:
30 parts of rhizoma polygonati, 20 parts of astragalus mongholicus, 40 parts of angelica dahurica, 20 parts of salvia miltiorrhiza, 20 parts of pseudo-ginseng, 20 parts of rhizoma gastrodiae, 15 parts of radix saposhnikoviae, 15 parts of angelica sinensis and 15 parts of ligusticum wallichii.
The preparation method of the medicine for treating the cerebral infarction comprises the following steps:
(1) screening raw material medicines, and sampling according to parts by weight;
(2) adding water 7-9 times the total weight of all the raw materials, boiling with strong fire, decocting with slow fire for 25-35min, and collecting decoction; adding water 5-7 times the total weight of the residue, boiling with strong fire, decocting with slow fire for 20-30min, mixing the two water decoctions, and mixing.
Compared with the prior art, the medicine of the invention has obvious advantages and effects, and the technical scheme can show that: the invention selects rhizoma polygonati, radix astragali, radix angelicae, radix salviae miltiorrhizae, radix notoginseng, rhizoma gastrodiae, radix sileris, angelica and rhizoma ligustici wallichii as raw materials, and achieves the effects of nourishing blood and promoting blood circulation, dispelling wind and removing obstruction in channels, and promoting blood circulation and removing blood stasis through the synergistic effect of the medicines, thereby achieving the purpose of treating cerebral infarction. The medicine of the invention has the advantages of quick effect, good curative effect, no toxic or side effect and convenient and quick administration. 98 cases of clinical treatment, and the total effective rate is 100 percent.
Detailed Description
The beneficial effects of the drug of the present invention are further illustrated by the following test examples.
Test example: clinical observations of the drug of the invention
1. Case selection
98 cases were treated, of which: age 30-70 years, 50 men and 48 women.
2. Criteria for disease diagnosis
The standard of curative effect for diagnosing the diseases of the traditional Chinese medicine.
3. The treatment method comprises the following steps:
the medicine prepared by the embodiment of the invention is orally taken three times a day, and one dose is taken in three days.
4. Criteria for therapeutic effect
The effect is shown: substantial elimination of all symptoms or elimination of chief symptoms;
the method has the following advantages: the chief symptoms are substantially eliminated or significantly improved;
and (4) invalidation: various symptoms and signs are unchanged.
5. The treatment results are as follows:
the medicine is used by all 98 patients, wherein 63 patients have obvious effect, 35 patients have effect, 0 patient has no effect, the obvious effect rate is 64.3 percent, and the total effective rate is 100 percent.
The preparation of the present medicament is illustrated by the following examples.
Example 1
A preparation method of a medicine for treating cerebral infarction comprises the following steps:
(1) screening raw material medicines, weighing 28g of rhizoma polygonati, 22g of astragalus mongholicus, 35g of angelica dahurica, 22g of salvia miltiorrhiza, 18g of pseudo-ginseng, 22g of rhizoma gastrodiae, 13g of radix sileris, 17g of angelica sinensis and 13g of ligusticum wallichii;
(2) adding water 9 times the total mass of all the raw materials, boiling with strong fire, decocting with slow fire for 35min, and collecting decoction; adding water 5 times the total weight of the residues, boiling with strong fire, decocting with slow fire for 20min, mixing the two water decoctions, and mixing.
Example 2
A preparation method of a medicine for treating cerebral infarction comprises the following steps:
(1) screening raw material medicines, weighing 30g of rhizoma polygonati, 20g of astragalus mongholicus, 40g of radix angelicae, 20g of salvia miltiorrhiza, 20g of pseudo-ginseng, 20g of rhizoma gastrodiae, 15g of radix saposhnikoviae, 15g of angelica sinensis and 15g of ligusticum wallichii;
(2) adding water 8 times the total mass of all the raw materials, boiling with strong fire, decocting with slow fire for 30min, and collecting decoction; adding water 6 times the total weight of the residues, boiling with strong fire, decocting with slow fire for 25min, mixing the two water decoctions, and mixing.
Example 3
A preparation method of a medicine for treating cerebral infarction comprises the following steps:
(1) screening raw material medicines, weighing 32g of rhizoma polygonati, 18g of astragalus mongholicus, 45g of radix angelicae, 18g of salvia miltiorrhiza, 22g of pseudo-ginseng, 18g of rhizoma gastrodiae, 17g of radix saposhnikoviae, 13g of angelica sinensis and 17g of ligusticum wallichii;
(2) adding water 7 times the total mass of all the raw materials, boiling with strong fire, decocting with slow fire for 25min, and collecting decoction; adding water 7 times the total weight of the residues, boiling with strong fire, decocting with slow fire for 30min, mixing the two water decoctions, and mixing.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, and any simple modification, equivalent change and modification made to the above embodiment according to the technical spirit of the present invention are within the scope of the present invention without departing from the technical spirit of the present invention.
Claims (3)
1. The medicine for treating the cerebral infarction comprises the following raw materials in parts by weight:
28-32 parts of rhizoma polygonati, 18-22 parts of astragalus mongholicus, 35-45 parts of radix angelicae, 18-22 parts of salvia miltiorrhiza, 18-22 parts of pseudo-ginseng, 18-22 parts of gastrodia elata, 13-17 parts of radix saposhnikoviae, 13-17 parts of angelica sinensis and 13-17 parts of ligusticum wallichii.
2. The medicine for treating the cerebral infarction as claimed in claim 1, which comprises the following raw materials in parts by weight:
30 parts of rhizoma polygonati, 20 parts of astragalus mongholicus, 40 parts of angelica dahurica, 20 parts of salvia miltiorrhiza, 20 parts of pseudo-ginseng, 20 parts of rhizoma gastrodiae, 15 parts of radix saposhnikoviae, 15 parts of angelica sinensis and 15 parts of ligusticum wallichii.
3. A medicament according to claim 1 or 2 for the treatment of cerebral infarction, the preparation method comprising the steps of:
(1) screening raw material medicines, and sampling according to parts by weight;
(2) adding water 7-9 times the total weight of all the raw materials, boiling with strong fire, decocting with slow fire for 25-35min, and collecting decoction; adding water 5-7 times the total weight of the residue, boiling with strong fire, decocting with slow fire for 20-30min, mixing the two water decoctions, and mixing.
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| CN201911096338.0A CN110833594A (en) | 2019-11-11 | 2019-11-11 | Medicine for treating cerebral infarction and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1112424A (en) * | 1993-11-12 | 1995-11-29 | 丁木 | Toutongning-medicine for headache |
| CN101347528A (en) * | 2008-08-29 | 2009-01-21 | 谭镒昌 | Chinese medicinal composition for resisting cardiovascular and cerebrovascular diseases |
| CN103479895A (en) * | 2013-09-12 | 2014-01-01 | 芦玉明 | Heart comforting and brain clearing traditional Chinese medicine composition |
| CN104173440A (en) * | 2013-05-28 | 2014-12-03 | 孙玉洁 | Traditional Chinese medicine for treating cerebral thrombus |
| CN108888738A (en) * | 2018-09-19 | 2018-11-27 | 宁波金未生物科技有限公司 | A kind of Chinese medicine composition that treating cerebral apoplexy, preparation and preparation method thereof and purposes |
-
2019
- 2019-11-11 CN CN201911096338.0A patent/CN110833594A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1112424A (en) * | 1993-11-12 | 1995-11-29 | 丁木 | Toutongning-medicine for headache |
| CN101347528A (en) * | 2008-08-29 | 2009-01-21 | 谭镒昌 | Chinese medicinal composition for resisting cardiovascular and cerebrovascular diseases |
| CN104173440A (en) * | 2013-05-28 | 2014-12-03 | 孙玉洁 | Traditional Chinese medicine for treating cerebral thrombus |
| CN103479895A (en) * | 2013-09-12 | 2014-01-01 | 芦玉明 | Heart comforting and brain clearing traditional Chinese medicine composition |
| CN108888738A (en) * | 2018-09-19 | 2018-11-27 | 宁波金未生物科技有限公司 | A kind of Chinese medicine composition that treating cerebral apoplexy, preparation and preparation method thereof and purposes |
Non-Patent Citations (2)
| Title |
|---|
| 周阿高: "《中医学》", 31 January 2012, 上海科学技术出版社 * |
| 朴天辉: "龙脑心胶囊的质量标准研究", 《黑龙江医学》 * |
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