CN114306436A - A Chinese medicinal composition cataplasma for treating osteoarticular pain and preparation method thereof - Google Patents
A Chinese medicinal composition cataplasma for treating osteoarticular pain and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition cataplasm for treating osteoarticular pain and a preparation method thereof, wherein the medicine raw materials in a main medicine extract comprise: cortex erythrinae, radix clematidis, radix angelicae pubescentis, semen brassicae, cortex eucommiae, radix achyranthis bidentatae, angelica sinensis, safflower, garden balsam stem, lycopodium clavatum, radix saposhnikoviae, herba siegesbeckiae, glossy privet fruit, herba epimedii, radix gentianae macrophyllae, ligusticum wallichii, radix angelicae, frankincense, myrrh, liquorice and teasel root, wherein the cataplasm body is prepared from polyvinyl alcohol, gelatin, sodium carboxymethylcellulose, chitin, sodium polyacrylate, propylene glycol, kaolin and purified water. The invention has the beneficial effects that: the medicines used in the invention are all plant medicines, and the effective components of the medicines are extracted through scientific formula to prepare the cataplasm convenient to use, the volatile oil component contained in the formula has double effects of treating and promoting medicine permeation, so that the effective components can play a better curative effect, and the cataplasm is an external preparation, has good compliance to patients and reduces possible side effects caused by the medicines.
Description
Technical Field
The invention relates to a traditional Chinese medicine composition cataplasm and a preparation method thereof, in particular to a traditional Chinese medicine composition cataplasm for treating osteoarticular pain and a preparation method thereof, belonging to the technical field of medicines.
Background
Osteoarthritis is an age-related multifactorial disease, is a chronic progressive osteoarthropathy with pathological characteristics of articular cartilage degenerative changes and periarticular hyperosteogeny, and is a common and frequent arthropathy of middle-aged and elderly people. Osteoarthritis of the knee is caused by obstruction of joints and meridians due to wind-cold-dampness. Knee osteoarthritis KOA is a common clinical chronic disease for the elderly, and if the early disease is not effectively controlled, the late treatment cannot obtain satisfactory curative effect, the disability rate is high, and the life quality of patients is seriously affected. The pubescent angelica and parasitic loranthus soup and the erythrina bark soup are classic traditional Chinese medicine prescriptions which are generally applied to clinical KOA treatment, and the modern literature research shows that the pubescent angelica and parasitic loranthus soup can obtain better curative effect through mechanisms of regulating inflammatory cytokines, promoting chondrocyte proliferation, regulating chondrocyte apoptosis and the like, and simultaneously tonify liver and kidney, dispel wind-cold-damp evil, stop knee bone arthralgia, treat both principal and secondary aspect of disease and has remarkable curative effect; the erythrina bark decoction has the effects of smoothing qi and blood, stretching channels and collaterals and eliminating swelling, and has definite curative effect on early and middle knee osteoarthritis through fumigation and washing.
Although the radix angelicae pubescentis and parasitic loranthus decoction and the erythrina bark decoction have obvious effects through years of clinical verification, the therapeutic effect of the medicine and the use compliance of patients are also deficient. The oral traditional Chinese medicine decoction has large dosage, and the smell of the traditional Chinese medicine decoction is unacceptable for patients; the erythrina bark decoction adopts fumigation and washing treatment, the operation is inconvenient, and most patients cannot take the medicine according to the treatment course; the drug effect is seriously affected.
Disclosure of Invention
The present invention aims at providing the traditional Chinese medicine composition cataplasm for treating osteoarticular pain and the preparation method thereof to solve the problems.
The invention achieves the aim through the following technical scheme, a traditional Chinese medicine composition cataplasm for treating osteoarticular pain, which comprises main medicine extract and cataplasm body;
the medicine in the main medicine extract is prepared from the following raw materials in parts by mass: 10-12g of erythrina bark, 10-12g of clematis root, 10-12g of pubescent angelica root, 10-12g of white mustard seed, 10-12g of eucommia bark, 10-12g of achyranthes root, 10-12g of angelica, 4-6g of safflower, 10-12g of garden balsam stem, 10-12g of lycopodium clavatum, 10-12g of divaricate saposhnikovia root, 10-12g of herba siegesbeckiae, 10-12g of glossy privet fruit, 10-12g of epimedium herb, 10-12g of gentiana macrophylla, 10-12g of szechuan lovage rhizome, 4-6g of angelica root, 4-6g of frankincense, 4-6g of myrrh, 10-12g of liquorice and 10-12g of dipsacus root;
the cataplasm is prepared from the following raw materials in percentage by mass: 8-10% of polyvinyl alcohol, 3-5% of gelatin, 8-10% of sodium carboxymethylcellulose, 8-10% of chitin, 35-40% of sodium polyacrylate, 3-5% of propylene glycol, 0.5-2% of kaolin and 10-30% of purified water.
The plaster is applied to acupoints including knee eye acupoint, calf nose acupoint, Huantiao acupoint and Ashi acupoint.
A preparation method of a traditional Chinese medicine composition cataplasm for treating bone joint pain comprises the following steps:
firstly, extracting the medicines to generate a main extract, preparing a cataplasm body, and then uniformly mixing the main extract and the cataplasm body to obtain a cataplasm paste;
then coating, pressing an anti-sticking layer, cutting and packaging the cataplasm paste to obtain the final product cataplasm.
The medicine is divided into two parts to be extracted in sequence;
the first part comprises radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, semen Sinapis Albae, radix Angelicae Dahuricae, herba Lycopodii, radix Angelicae Pubescentis, radix Clematidis, radix Dipsaci, herba Speranskiae Tuberculatae, Eucommiae cortex, radix Saposhnikoviae and radix Gentianae Marcrophyllae;
the second part comprises cortex Erythrinae, Carthami flos, Siegesbeckiae herba, fructus Ligustri Lucidi, herba Epimedii, Olibanum, Myrrha, Glycyrrhrizae radix and Achyranthis radix.
The extraction of the two parts of medicines comprises the following steps:
the first step is as follows: extracting volatile oil from the first part of the medicine by adopting a steam distillation method, and collecting the volatile oil to obtain mixed volatile oil;
the second step is that: mixing the residue after distillation with the second part of the medicinal materials, decocting with ten times of water for 1-1.2 hr for the first time, filtering to obtain the first decoction, decocting with eight times of water for 30-40min for the second time, and filtering to obtain the second decoction;
the third step: mixing the two decocted liquid medicines and concentrating to obtain thick paste;
the fourth step: adding the mixed volatile oil into the thick paste, and uniformly mixing the two to obtain the main drug extract.
The processing of the babu paste raw material comprises the following steps:
the first step is as follows: dispersing chitin in purified water, stirring until the chitin is completely swelled, adding purified water, and stirring uniformly;
the second step is that: adding polyvinyl alcohol into purified water, heating at 70 ℃, adding sodium carboxymethylcellulose after the polyvinyl alcohol is swelled, and uniformly stirring;
the third step: adding gelatin into purified water, heating at 50 deg.C for swelling, adding kaolin, and stirring;
the fourth step: mixing the substances obtained in the first step to the third step together and stirring uniformly;
the fifth step: dispersing sodium polyacrylate into propylene glycol, adding purified water, and stirring to obtain transparent colloid;
and a sixth step: and (4) mixing the substances obtained in the fourth step and the fifth step, and uniformly stirring at 50 ℃ to finally obtain the cataplasm.
The preparation of the finished cataplasm comprises the following steps;
the method comprises the following steps: mixing the obtained main drug extract and the cataplasm body, and then uniformly stirring;
step two: uniformly coating the obtained mixture on a non-woven fabric, wherein the coating thickness is 0.3-0.6 mm;
step three: after being smeared, the ointment is placed for 24 hours at the temperature of 25-27 ℃, and after being placed, an anti-sticking layer is covered on the ointment;
step four: and cutting the prepared paste into blocks, and then packaging the blocks.
Preferably, the top end of the non-woven fabric is provided with a drug adsorption area, the main drug extract and the cataplasm body are smeared on the drug adsorption area, and the main drug extract is mixed with the first part of the medicinal material volatile oil.
The invention has the beneficial effects that:
1. the invention removes the dregs of the decoction of the effective components of the Chinese traditional medicine, extracts the effective components reasonably to make the effective components exert the drug effect better, especially effectively extracts the volatile oil components of the Chinese traditional medicine to exert the effect of the volatile oil components and has the effect of promoting the absorption of other effective components.
2. The invention combines the advantages of the pubescent angelica and mistletoe decoction and the erythrina bark decoction, reasonably combines and cuts the medicines of the two formulas, removes coarse extract by a modern scientific and reasonable extraction method, particularly intensively extracts the volatile oil to play the main medicine effect and the transdermal absorption effect of the volatile oil, and is more beneficial to the play of the medicine effect.
3. The invention provides a safe, effective and convenient medicament for bone joint pain patients. Is especially suitable for the middle-aged and the elderly people. Has good curative effects on knee joint pain, femoral head and necrosis, lumbago, muscle strain, etc.
4. The semen brassicae capable of correcting oxygen free radical metabolic disorder and treating knee osteoarthritis is creatively added, and the semen brassicae has the effects of dissipating blood stasis and relieving pain, warming spleen and stomach for dispelling cold, dredging collaterals and relieving pain, and can be used for removing limb joint congestion and relieving numbness and pain; can directly reach the knee joint to play a role in dredging the channels and collaterals; the advantage of treating the inflammation of joints and the like is that the dependence of the medicine and the promotion effect of transdermal absorption are avoided, so that the pains of bones, muscles and waist sections of joints and the like are treated.
5. The medicines used in the invention are all plant medicines, and the effective components of the medicines are extracted through scientific formula to prepare the cataplasm convenient to use, the volatile oil component contained in the formula has double effects of treating and promoting medicine permeation, so that the effective components can play a better curative effect, and the cataplasm is an external preparation, has good compliance to patients and reduces possible side effects caused by the medicines.
Drawings
FIG. 1 is a flow chart of the process of the present invention;
FIG. 2 is a flow chart of the preparation of the cataplasma of the present invention;
FIG. 3 is a table of the formula of the cataplasm matrix of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-3, a Chinese medicinal composition cataplasm for treating osteoarticular pain comprises main ingredient extracts and cataplasma;
the medicine in the main medicine extract is prepared from the following raw materials in parts by mass: 10-12g of erythrina bark, 10-12g of clematis root, 10-12g of pubescent angelica root, 10-12g of white mustard seed, 10-12g of eucommia bark, 10-12g of achyranthes root, 10-12g of angelica, 4-6g of safflower, 10-12g of garden balsam stem, 10-12g of lycopodium clavatum, 10-12g of divaricate saposhnikovia root, 10-12g of herba siegesbeckiae, 10-12g of glossy privet fruit, 10-12g of epimedium herb, 10-12g of gentiana macrophylla, 10-12g of szechuan lovage rhizome, 4-6g of angelica root, 4-6g of frankincense, 4-6g of myrrh, 10-12g of liquorice and 10-12g of dipsacus root;
the cortex erythrinae, speranskia tuberculata, radix clematidis and radix angelicae have the effects of clearing and activating the channels and collaterals, warming the channels for dispelling cold, removing dampness and relieving pain, promoting blood circulation for dispelling cold and smoothing blood circulation for removing stagnation;
the angelica, the ligusticum wallichii, the safflower, the frankincense and the myrrh can remove blood stasis, activate blood, reduce swelling and relieve pain; meanwhile, the radix angelicae pubescentis is used for dispelling wind and removing dampness, nourishing blood and regulating ying, activating collaterals and dredging paralysis;
the achyranthes and the eucommia have better efficacies of tonifying liver and kidney and strengthening muscles and bones, and the two medicinal materials are taken as adjuvant medicines; meanwhile, the ligusticum wallichii and the angelica are used for enriching and activating blood;
the combination of the large-leaved gentian and the divaricate saposhnikovia root also has the function of dispelling wind cold and dampness of the whole body, and the liquorice coordinates various medicinal materials so as to achieve the effects of dispelling wind-damp, dredging the channels and collaterals, dispelling cold evil, dispelling blood stasis, eliminating swelling and pain and freeing arthralgia pain together.
The cataplasm is prepared from the following raw materials in percentage by mass: 8-10% of polyvinyl alcohol, 3-5% of gelatin, 8-10% of sodium carboxymethylcellulose, 8-10% of chitin, 35-40% of sodium polyacrylate, 3-5% of propylene glycol, 0.5-2% of kaolin and 10-30% of purified water.
The medicinal materials include polyvinyl alcohol, gelatin, chitin and sodium polyacrylate as adhesive to ensure the viscosity of the preparation, sodium carboxymethyl cellulose as thickener, propylene glycol as humectant and kaolin as filler.
As a technical optimization scheme of the invention, the application acupuncture points of the cataplasm comprise a knee eye acupuncture point, a calf nose acupuncture point, a Huantiao acupuncture point and an Ashi acupuncture point;
the knee eye acupuncture points, which are called as knee eyes, are positioned on the extending side of the knee joint and in the depressions on the two sides of the patellar ligament, and the left and right acupuncture points contain four acupuncture points in total, are mainly used for treating knee joint ache, gonarthritis, crane knee wind, leg pain, beriberi, lower finger paralysis, lower limb impotence, weakness and the like, and can also be used for treating apoplexy, abdominal colic, scabies and the like;
calf nose acupoint, also called outer knee eye acupoint, belongs to ZUYANMINGWEI channel, and has effects of dredging meridian passage, dispelling pathogenic wind and cold, regulating qi-flowing, relieving swelling and pain;
the Huantiao acupoint is the meridian acupoint of the gallbladder meridian of foot Shaoyang, the acupoint is close to the hip joint, and is used for lower limb movement, when the lower limb bends the knee and bends the hip to make the circumflex and jump;
the points a, also known as indefinite points, tianying points, and pressure pain points, are located near the affected area or at a distance from the affected area, and the point selection method is based on pain as the point, i.e., the point with pain is commonly known as the "pain point".
A preparation method of a traditional Chinese medicine composition cataplasm for treating bone joint pain comprises the following steps:
firstly, extracting the medicines to generate a main extract, preparing a cataplasm body, and then uniformly mixing the main extract and the cataplasm body to obtain a cataplasm paste;
then coating, pressing an anti-sticking layer, cutting and packaging the cataplasm paste to obtain the final product cataplasm.
As a technical optimization scheme of the invention, the medicine is divided into two parts to be extracted in sequence;
the first part comprises radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, semen Sinapis Albae, radix Angelicae Dahuricae, herba Lycopodii, radix Angelicae Pubescentis, radix Clematidis, radix Dipsaci, herba Speranskiae Tuberculatae, Eucommiae cortex, radix Saposhnikoviae and radix Gentianae Marcrophyllae;
the second part comprises cortex Erythrinae, Carthami flos, Siegesbeckiae herba, fructus Ligustri Lucidi, herba Epimedii, Olibanum, Myrrha, Glycyrrhrizae radix and Achyranthis radix.
As a technical optimization scheme of the invention, the extraction of the two parts of medicines comprises the following steps:
the first step is as follows: extracting volatile oil from the first part of the medicine by adopting a steam distillation method, and collecting the volatile oil to obtain mixed volatile oil;
because the volatile components of the traditional Chinese medicine are mostly active ingredients and can be volatilized in the common extraction or decoction treatment process, the essence of the medicinal materials is not preserved, the due curative effect of the medicinal materials is achieved, and the waste of resources is caused, so that the water vapor distillation method is adopted for extracting the essence of the medicinal materials.
The second step is that: mixing the residue after distillation with the second part of the medicinal materials, decocting with ten times of water for 1-1.2 hr for the first time, filtering to obtain the first decoction, decocting with eight times of water for 30-40min for the second time, and filtering to obtain the second decoction;
the third step: mixing the two decocted liquid medicines and concentrating to obtain thick paste;
the fourth step: adding the mixed volatile oil into the thick paste, and uniformly mixing the two to obtain the main drug extract.
The processing of the babu paste raw material comprises the following steps:
the first step is as follows: dispersing chitin in purified water, stirring until the chitin is completely swelled, adding purified water, and stirring uniformly;
the second step is that: adding polyvinyl alcohol into purified water, heating at 70 ℃, adding sodium carboxymethylcellulose after the polyvinyl alcohol is swelled, and uniformly stirring;
the third step: adding gelatin into purified water, heating at 50 deg.C for swelling, adding kaolin, and stirring;
the fourth step: mixing the substances obtained in the first step to the third step together and stirring uniformly;
the fifth step: dispersing sodium polyacrylate into propylene glycol, adding purified water, and stirring to obtain transparent colloid;
and a sixth step: and (4) mixing the substances obtained in the fourth step and the fifth step, and uniformly stirring at 50 ℃ to finally obtain the cataplasm.
As a technical optimization scheme of the invention, the preparation of the finished cataplasm comprises the following steps;
the method comprises the following steps: mixing the obtained main drug extract and the cataplasm body, and then uniformly stirring;
the cataplasma and the main extract must be stirred uniformly without visible lumps.
Step two: uniformly coating the obtained mixture on a non-woven fabric, wherein the coating thickness is 0.3-0.6 mm;
the time from extruding the cataplasm from the hopper to coating the non-woven fabric is not more than half an hour, the tail gum is prevented from being coated difficultly, and the pH value of the gum solution is adjusted to about 7.0.
Step three: after being smeared, the ointment is placed for 24 hours at the temperature of 25-27 ℃, and after being placed, an anti-sticking layer is covered on the ointment;
step four: and cutting the prepared paste into blocks, and then packaging the blocks.
The extract of the invention can also be prepared into other preparations, such as: oral solid preparations (tablets, capsules, soft capsules, etc.).
The top end of the non-woven fabric is provided with a medicine adsorption area, the main medicine extract and the cataplasm body are smeared on the medicine adsorption area, the main medicine extract is mixed with a first part of medicinal material volatile oil, the medicinal materials are extracted into the volatile oil, the characteristic of transdermal absorption of the volatile oil can be utilized, more medicine essences can be absorbed by a human body, and therefore the effect of the traditional Chinese medicinal materials can be exerted to the greatest extent.
When the invention is used, the self needle-shaped medicine is eliminated according to the requirement, and is correspondingly pasted on four acupuncture points of knee eye acupuncture point, calf nose acupuncture point, jumping around acupuncture point or Ashi acupuncture point of the medicine, and the essence of the medicine is absorbed through the acupuncture points, thereby achieving the effects of relieving diseases and relieving pain.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (8)
1. A traditional Chinese medicine composition cataplasm for treating osteoarticular pain is characterized in that: the composition components of the cataplasm comprise a main medicine extract and a cataplasm body;
the medicine in the main medicine extract is prepared from the following raw materials in parts by mass: 10-12g of erythrina bark, 10-12g of clematis root, 10-12g of pubescent angelica root, 10-12g of white mustard seed, 10-12g of eucommia bark, 10-12g of achyranthes root, 10-12g of angelica, 4-6g of safflower, 10-12g of garden balsam stem, 10-12g of lycopodium clavatum, 10-12g of divaricate saposhnikovia root, 10-12g of herba siegesbeckiae, 10-12g of glossy privet fruit, 10-12g of epimedium herb, 10-12g of gentiana macrophylla, 10-12g of szechuan lovage rhizome, 4-6g of angelica root, 4-6g of frankincense, 4-6g of myrrh, 10-12g of liquorice and 10-12g of dipsacus root;
the cataplasm is prepared from the following raw materials in percentage by mass: 8-10% of polyvinyl alcohol, 3-5% of gelatin, 8-10% of sodium carboxymethylcellulose, 8-10% of chitin, 35-40% of sodium polyacrylate, 3-5% of propylene glycol, 0.5-2% of kaolin and 10-30% of purified water.
2. The cataplasm as a Chinese medicinal composition for treating osteoarticular pain according to claim 1, which is characterized in that: the plaster is applied to acupoints including knee eye acupoint, calf nose acupoint, Huantiao acupoint and Ashi acupoint.
3. A preparation method of a traditional Chinese medicine composition cataplasm for treating osteoarticular pain is characterized by comprising the following steps: the preparation of the cataplasm comprises the following processes:
firstly, extracting the medicines to generate a main extract, preparing a cataplasm body, and then uniformly mixing the main extract and the cataplasm body to obtain a cataplasm paste;
then coating, pressing an anti-sticking layer, cutting and packaging the cataplasm paste to obtain the final product cataplasm.
4. The preparation method of the traditional Chinese medicine composition cataplasm for treating osteoarticular pain according to claim 3, which is characterized by comprising the following steps: the medicine is divided into two parts to be extracted in sequence;
the first part comprises radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, semen Sinapis Albae, radix Angelicae Dahuricae, herba Lycopodii, radix Angelicae Pubescentis, radix Clematidis, radix Dipsaci, herba Speranskiae Tuberculatae, Eucommiae cortex, radix Saposhnikoviae and radix Gentianae Marcrophyllae;
the second part comprises cortex Erythrinae, Carthami flos, Siegesbeckiae herba, fructus Ligustri Lucidi, herba Epimedii, Olibanum, Myrrha, Glycyrrhrizae radix and Achyranthis radix.
5. The preparation method of the traditional Chinese medicine composition cataplasm for treating osteoarticular pain according to claim 4, which is characterized by comprising the following steps: the extraction of the two parts of medicines comprises the following steps:
the first step is as follows: extracting volatile oil from the first part of the medicine by adopting a steam distillation method, and collecting the volatile oil to obtain mixed volatile oil;
the second step is that: mixing the residue after distillation with the second part of the medicinal materials, decocting with ten times of water for 1-1.2 hr for the first time, filtering to obtain the first decoction, decocting with eight times of water for 30-40min for the second time, and filtering to obtain the second decoction;
the third step: mixing the two decocted liquid medicines and concentrating to obtain thick paste;
the fourth step: adding the mixed volatile oil into the thick paste, and uniformly mixing the two to obtain the main drug extract.
6. The preparation method of the traditional Chinese medicine composition cataplasm for treating osteoarticular pain according to claim 3, which is characterized by comprising the following steps: the processing of the babu paste raw material comprises the following steps:
the first step is as follows: dispersing chitin in purified water, stirring until the chitin is completely swelled, adding purified water, and stirring uniformly;
the second step is that: adding polyvinyl alcohol into purified water, heating at 70 ℃, adding sodium carboxymethylcellulose after the polyvinyl alcohol is swelled, and uniformly stirring;
the third step: adding gelatin into purified water, heating at 50 deg.C for swelling, adding kaolin, and stirring;
the fourth step: mixing the substances obtained in the first step to the third step together and stirring uniformly;
the fifth step: dispersing sodium polyacrylate into propylene glycol, adding purified water, and stirring to obtain transparent colloid;
and a sixth step: and (4) mixing the substances obtained in the fourth step and the fifth step, and uniformly stirring at 50 ℃ to finally obtain the cataplasm.
7. The preparation method of the traditional Chinese medicine composition cataplasm for treating osteoarticular pain according to claim 3, which is characterized by comprising the following steps: the preparation of the finished cataplasm comprises the following steps;
the method comprises the following steps: mixing the obtained main drug extract and the cataplasm body, and then uniformly stirring;
step two: uniformly coating the obtained mixture on a non-woven fabric, wherein the coating thickness is 0.3-0.6 mm;
step three: after being smeared, the ointment is placed for 24 hours at the temperature of 25-27 ℃, and after being placed, an anti-sticking layer is covered on the ointment;
step four: and cutting the prepared paste into blocks, and then packaging the blocks.
8. The preparation method of the traditional Chinese medicine composition cataplasm for treating osteoarticular pain according to claim 7, which is characterized by comprising the following steps: the top end of the non-woven fabric is provided with a medicine adsorption area, the main medicine extract and the cataplasm are smeared on the medicine adsorption area, and the main medicine extract is mixed with a first part of medicinal material volatile oil.
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