CN102178895B - Chinese medicine composition for treating orthopedic disorders and preparation method thereof - Google Patents

Chinese medicine composition for treating orthopedic disorders and preparation method thereof Download PDF

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CN102178895B
CN102178895B CN2011101067698A CN201110106769A CN102178895B CN 102178895 B CN102178895 B CN 102178895B CN 2011101067698 A CN2011101067698 A CN 2011101067698A CN 201110106769 A CN201110106769 A CN 201110106769A CN 102178895 B CN102178895 B CN 102178895B
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radix
preparata
chinese medicine
composition
rhizoma
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CN2011101067698A
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CN102178895A (en
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胡建忠
严纪辉
胡琦
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胡建忠
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Abstract

The invention discloses a Chinese medicine composition for treating orthopedic disorders and a preparation method thereof. The Chinese medicine composition comprises the following components: 140-160g of rhizoma drynariae, 90-110g of eucommia bark, 90-110g of teasel root, 90-110g of bidentate achyranthes root, 20-30g of frankincense, 20-30g of myrrha, 140-160g of the red-rooted salvia root, 40-60g of flos carthami, 90-110g of panax pseudoginseng, 90-110g of szechuan lovage rhizome, 10-20g of prepared common monkshood mother root, 10-20g of prepared radix aconiti kusnezoffii, 90-110g of Chinese clematis, 90-110g of fructus chaenomelis lagenariae, 140-160g of radix astragali, 90-110g of Chinese angelica, 140-160g of prepared rehmannia root, 90-110g of ground beeltle, 40-60g of scorpio, 40-60g of lumbricus, 90-110g of snake slough, 140-160g of radix curcumae, 15-30g rhizoma curcumae longae and 40-60g of liquoric root. The invention has the advantages of special formula, remarkable effect, simple preparation method and easiness in operation.

Description

A kind of Chinese medicine composition of treating orthopaedic disease and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, be specifically related to a kind ofly can treat Chinese medicine composition of orthopaedic disease and preparation method thereof.
Background technology
Orthopaedic disease is a kind of common frdquently encountered disease, needs could cure for a long time, influences patient's orthobiosis.Femur head necrosis, hyperosteogeny, traumatic injury and arthritis are more common orthopaedic disease, especially femur head necrosis and hyperosteogeny, and not only longer duration also is difficult to cure.
Above-mentioned disease can adopt external medication also can adopt the endo-medicine treatment when treatment, and external used medicine directly acts on disease institute, and rapid-action, effect is better.But, then must adopt endo-medicine to play the effect of treatment for the patient who is not suitable for external used medicine.Endo-medicine commonly used is generally anti-inflammatory analgesic class medicine, and like indometacin, ibuprofen etc., analgesic effect is strong, and antiinflammatory and anti rheumatism action are also stronger.But these medicines can not be taken the long period and these methods of clinical practice can only the alleviating pain symptom, can't play the effect of radical cure, and these medicines are very big to liver, kidney, gastrointestinal damage, and side effect is obvious.In recent years, theory of Chinese medical science more and more came into one's own, and many people beginning on selecting is transformed into Chinese medicine by Western medicine gradually, and the Chinese medicine side effect is little, can treating both the principal and secondary aspects of a disease, and the orthopaedic disease of taking medicine for a long time for needs has certain advantage.
Summary of the invention
The present invention is big according to existing orthopaedic disease oral drugs side effect, and the deficiency of therapeutic effect difference provides a kind of Chinese medicine composition of treating orthopaedic disease, and this medicine can invigorating blood circulation paralysis, the kidney invigorating bone strengthening, dispelling cold by warming the meridian, removing obstruction in the collateral to relieve pain ,Therapeutic effect is good and have no side effect.
The present invention also provides the method for preparing of this Chinese medicine composition.
The inventor is through research and clinical experiment for many years; Take into full account the pharmacological action of various Chinese crude drugs; Drawn the pharmaceutical composition that can treat orthopaedic disease, this medicine is good to orthopaedic disease therapeutic effect such as femur head necrosis, hyperosteogeny, various traumatic injury and arthritis.
The concrete technical scheme of the present invention is following:
A kind of Chinese medicine composition of treating orthopaedic disease is characterized in that comprising following composition:
Rhizoma Drynariae (stir-fry) 140-160g; The Cortex Eucommiae (stir-fry) 90-110g; Radix Dipsaci (system) 90-110g; Radix Achyranthis Bidentatae 90-110g; Olibanum (system) 20-30g; Myrrha (processed) 20-30g; Radix Salviae Miltiorrhizae 140-160g; Flos Carthami 40-60g; Radix Notoginseng 90-110g; Rhizoma Chuanxiong 90-110g; Radix Aconiti Preparata 10-20g; Radix Aconiti Kusnezoffii Preparata 10-20g; Radix Clematidis 90-110g; Fructus Chaenomelis 90-110g; Radix Astragali 140-160g; Radix Angelicae Sinensis 90-110g; Radix Rehmanniae Preparata 140-160g; Eupolyphaga Seu Steleophaga 90-110g; Scorpio 40-60g; Pheretima 40-60g; Periostracum Serpentis (system) 90-110g; Radix Curcumae 140-160g; Rhizoma Wenyujin Concisum 15-30g; Radix Glycyrrhizae (processing) 40-60g.
Further, in the above-mentioned Chinese medicine composition, optimization formula is:
Rhizoma Drynariae (stir-fry) 160g, the Cortex Eucommiae (stir-fry) 103g, Radix Dipsaci (system) 105g, Radix Achyranthis Bidentatae 90g, Olibanum (system) 30g, Myrrha (processed) 30g, Radix Salviae Miltiorrhizae 150g, Flos Carthami 55g, Radix Notoginseng 107g, Rhizoma Chuanxiong 98g, Radix Aconiti Preparata 12g, Radix Aconiti Kusnezoffii Preparata 14g, Radix Clematidis 108g, Fructus Chaenomelis 95g, Radix Astragali 160g, Radix Angelicae Sinensis 95g, Radix Rehmanniae Preparata 158g, Eupolyphaga Seu Steleophaga 95g, Scorpio 60g, Pheretima 44g, Periostracum Serpentis (system) 90g, Radix Curcumae 152g, Rhizoma Wenyujin Concisum 30g, Radix Glycyrrhizae (processing) 50g.
Further, in the above-mentioned Chinese medicine composition, optimization formula is:
Rhizoma Drynariae (stir-fry) 145-155g; The Cortex Eucommiae (stir-fry) 95-105g; Radix Dipsaci (system) 95-105g; Radix Achyranthis Bidentatae 95-105g; Olibanum (system) 22-27g; Myrrha (processed) 22-27g; Radix Salviae Miltiorrhizae 145-155g; Flos Carthami 45-55g; Radix Notoginseng 95-105g; Rhizoma Chuanxiong 95-105g; Radix Aconiti Preparata 13-17g; Radix Aconiti Kusnezoffii Preparata 13-17g; Radix Clematidis 95-105g; Fructus Chaenomelis 95-105g; Radix Astragali 145-155g; Radix Angelicae Sinensis 95-105g; Radix Rehmanniae Preparata 145-155g; Eupolyphaga Seu Steleophaga 95-105g; Scorpio 45-55g; Pheretima 45-55g; Periostracum Serpentis (system) 95-105g; Radix Curcumae 145-155g; Rhizoma Wenyujin Concisum 17-25g; Radix Glycyrrhizae (processing) 45-55g.
Further, in the above-mentioned Chinese medicine composition, most preferably prescription is:
Rhizoma Drynariae (stir-fry) 150g, the Cortex Eucommiae (stir-fry) 100g, Radix Dipsaci (system) 100g, Radix Achyranthis Bidentatae 100g, Olibanum (system) 25g, Myrrha (processed) 25g, Radix Salviae Miltiorrhizae 150g, Flos Carthami 50g, Radix Notoginseng 100g, Rhizoma Chuanxiong 100g, Radix Aconiti Preparata 15g, Radix Aconiti Kusnezoffii Preparata 15g, Radix Clematidis 100g, Fructus Chaenomelis 100g, Radix Astragali 150g, Radix Angelicae Sinensis 100g, Radix Rehmanniae Preparata 150g, Eupolyphaga Seu Steleophaga 100g, Scorpio 50g, Pheretima 50g, Periostracum Serpentis (system) 100g, Radix Curcumae 150g, Rhizoma Wenyujin Concisum 20g, Radix Glycyrrhizae (processing) 50g.
Chinese medicine composition of the present invention, its dosage form are the watered pill.
The present invention also provides the method for preparing of the Chinese medicine composition of treatment orthopaedic disease, it is characterized in that: 20 four Chinese medicine thing pulverize separately being become fine powder, sieve then, mixing, is binding agent with water, processes the watered pill through general method for making.
The used purified water of preparation meets " Chinese pharmacopoeia version prescription in 2000.
The obtained watered pill of the present invention is the watered pill of sepia or yellowish-brown, and feeble QI, mildly bitter flavor, the watered pill meet each item regulation (appendix IA of Chinese Pharmacopoeia version in 2000) relevant under the pill item.When taking, a 5g, 2 times on the one, children's is cut down according to the circumstance.Anemia of pregnant woman's forbidding.
Adopt 24 flavor Chinese medicine medical materials in the present invention prescription altogether, each medicine be " Chinese pharmacopoeia one one of version in 2000 is recorded kind, its quality through check meet " regulation of Chinese pharmacopoeia, the effect of each medicine material is following:
Rhizoma Drynariae: nature and flavor are bitter, temperature; Gui Jing returns kidney, Liver Channel; Effect, the kidney invigorating bone strengthening continues and hinders pain relieving.
The Cortex Eucommiae: nature and flavor are sweet, temperature; Return liver, kidney channel; Effect, invigorating the liver and kidney, bone and muscle strengthening.Antiabortive.
Radix Dipsaci: nature and flavor, bitter, hot, tepor; Gui Jing returns liver, kidney channel; Effect, invigorating the liver and kidney, bone and muscle strengthening, continuous folding is hindered, and ends metrorrhagia.
Radix Achyranthis Bidentatae: nature and flavor are bitter, sour, flat; Return liver, kidney channel; Effect, invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.
Olibanum: nature and flavor are arduous, temperature; Gui Jing goes into the heart, liver, spleen channel; Effect, regulating qi and activating blood, analgesic therapy chases after poison.
Myrrha: another name, myrrh (" detailed outline "), bright Myrrha " national Chinese herbal medicine compilation ", nature and flavor are bitter, and suffering is flat; Gui Jing goes into the heart, liver; Effect, the blood blood stasis removing that looses, subduing swelling and relieving pain.
Radix Salviae Miltiorrhizae: nature and flavor, hardship is slightly cold; Gui Jing, GUIXIN, Liver Channel; Effect, stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.
Flos Carthami: nature and flavor, suffering, temperature; Gui Jing, GUIXIN, Liver Channel; Effect, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.
Radix Notoginseng: nature and flavor, sweet, little hardship, temperature; Gui Jing returns liver, stomach warp; Effect, dissipating blood stasis hemostasis, subduing swelling and relieving pain.
Rhizoma Chuanxiong: nature and flavor, suffering, temperature; Gui Jing returns liver, gallbladder, pericardium channel; Effect, blood-activating and qi-promoting, wind-expelling pain-stopping.
Radix Aconiti Preparata: nature and flavor, hot, bitter, heat, poisonous; Gui Jing, GUIXIN, liver, kidney, board warp; Effect, expelling wind and removing dampness, antalgic.
Radix Aconiti Kusnezoffii Preparata: nature and flavor are hot, bitter, heat; Poisonous; Gui Jing, GUIXIN, liver,kidney,spleen warp; Effect, expelling wind and removing dampness, antalgic.
Radix Clematidis: nature and flavor are hot, salty, temperature; Gui Jing returns urinary bladder channel; Effect, expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.
Fructus Chaenomelis: nature and flavor, acid, temperature; Gui Jing returns liver, spleen channel; Effect, suppressing the hyperactive liver Shujin, stomach function regulating removing dampness.
The Radix Astragali: nature and flavor, sweet, temperature; Gui Jing returns lung, spleen channel; Effect, invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.
Radix Angelicae Sinensis: nature and flavor, sweet, hot, temperature; Gui Jing returns liver, the heart, spleen channel; Effect is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Radix Rehmanniae Preparata: nature and flavor, sweet, tepor; Gui Jing returns liver, kidney channel; Effect, nourishing YIN and supplementing blood, beneficial essence is filled out marrow.
Eupolyphaga Seu Steleophaga: another name, Eupolyphaga Seu Steleophaga, eupolyphaga, DIWUGUI 、 female ground beetle; Nature and flavor are salty, cold; Slightly poisonous; Gui Jing returns Liver Channel; Function cures mainly, removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.
Scorpio: nature and flavor, suffering, flat; Poisonous; Gui Jing returns Liver Channel; Effect, endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.
Pheretima: nature and flavor are salty, cold; Gui Jing returns liver, spleen, urinary bladder channel; Effect, the heat clearing away arresting convulsion, collateral dredging is relievingd asthma, diuresis.
Periostracum Serpentis: nature and flavor are salty, sweet, flat; Gui Jing returns Liver Channel; Effect is dispeled the wind, arresting convulsion, detoxifcation, nebula removing.
Radix Curcumae: nature and flavor, hot, bitter, cold; Gui Jing returns liver, the heart, lung meridian; Effect, regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.
Rhizoma Wenyujin Concisum: nature and flavor, hot, bitter, temperature; Gui Jing returns liver, spleen channel; Effect, removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.
Radix Glycyrrhizae (processing): nature and flavor, sweet, flat; Gui Jing, GUIXIN.Lung, spleen, stomach warp; Effect, Anew Issue Plate stomach function regulating, Yiqi and vein recovery.
The present invention adopts 20 four Chinese medicine things as effective ingredient, and prescription is unique, and each medicine plays a role separately, through the coordinated of each medicine, makes medicine reach invigorating blood circulation paralysis, the kidney invigorating bone strengthening, dispelling cold by warming the meridian, the effect of removing obstruction in the collateral to relieve pain.Medicine of the present invention can be used for treating orthopaedic diseases such as femur head necrosis, hyperosteogeny, various traumatic injury and arthritis, and healing time is short, cure rate is high, have no side effect, and effect is obvious.Process for preparing medicine of the present invention is simple, easy operating, is convenient to industrial applications.
The specific embodiment
Further set forth through the present invention of specific embodiment degree below, should be understood that, following explanation only is in order to explain the present invention, its particular content not to be limited.
Medicine of the present invention is an effective ingredient with Rhizoma Drynariae (stir-fry), the Cortex Eucommiae (stir-fry), Radix Dipsaci (system), Radix Achyranthis Bidentatae, Olibanum (system), Myrrha (processed), Radix Salviae Miltiorrhizae, Flos Carthami, Radix Notoginseng, Rhizoma Chuanxiong, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Clematidis, Fructus Chaenomelis, the Radix Astragali, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Eupolyphaga Seu Steleophaga, Scorpio, Pheretima, Periostracum Serpentis (system), Radix Curcumae, Rhizoma Wenyujin Concisum, this 20 four Chinese medicine of Radix Glycyrrhizae (processing), and various medical materials all can have been bought in market.The present invention adopts general method for making; Medicine is processed the watered pill, can be when practical application according to the consumption of different each medical materials of needs conversion, its concrete method for preparing is: above 24 flavors; By recipe quantity get, be ground into fine powder respectively only, sieve, mixing; According to " requirement of a pill general rule of Chinese pharmacopoeia version in 2000 through molding, pill, select ball, drying, packing, labeling, checkout procedure, is made adjuvant with purified water; General ball forms, and the used purified water of preparation meets " Chinese pharmacopoeia version prescription in 2000.The heavy 1g of per 15 balls of the gained watered pill.
Embodiment 1
Adopt the method for preparing watered pill of the present invention, the prescription of said medicine is: Rhizoma Drynariae (stir-fry) 150g, the Cortex Eucommiae (stir-fry) 100g, Radix Dipsaci (system) 100g, Radix Achyranthis Bidentatae 100g, Olibanum (system) 25g, Myrrha (processed) 25g, Radix Salviae Miltiorrhizae 150g, Flos Carthami 50g, Radix Notoginseng 100g, Rhizoma Chuanxiong 100g, Radix Aconiti Preparata 15g, Radix Aconiti Kusnezoffii Preparata 15g, Radix Clematidis 100g, Fructus Chaenomelis 100g, Radix Astragali 150g, Radix Angelicae Sinensis 100g, Radix Rehmanniae Preparata 150g, Eupolyphaga Seu Steleophaga 100g, Scorpio 50g, Pheretima 50g, Periostracum Serpentis (system) 100g, Radix Curcumae 150g, Rhizoma Wenyujin Concisum 20g, Radix Glycyrrhizae (processing) 50g.
Embodiment 2
Adopt the method for preparing watered pill of the present invention, the prescription of said medicine is: Rhizoma Drynariae (stir-fry) 160g, the Cortex Eucommiae (stir-fry) 110g, Radix Dipsaci (system) 108g, Radix Achyranthis Bidentatae 98g, Olibanum (system) 27g, Myrrha (processed) 27g, Radix Salviae Miltiorrhizae 145g, Flos Carthami 50g, Radix Notoginseng 98g, Rhizoma Chuanxiong 105g, Radix Aconiti Preparata 13g, Radix Aconiti Kusnezoffii Preparata 17g, Radix Clematidis 110g, Fructus Chaenomelis 110g, Radix Astragali 160g, Radix Angelicae Sinensis 100g, Radix Rehmanniae Preparata 155g, Eupolyphaga Seu Steleophaga 100g, Scorpio 60g, Pheretima 45g, Periostracum Serpentis (system) 98g, Radix Curcumae 140g, Rhizoma Wenyujin Concisum 17g, Radix Glycyrrhizae (processing) 55g.
Embodiment 3
Adopt the method for preparing watered pill of the present invention, the prescription of said medicine is: Rhizoma Drynariae (stir-fry) 145g, the Cortex Eucommiae (stir-fry) 95g, Radix Dipsaci (system) 105g, Radix Achyranthis Bidentatae 105g, Olibanum (system) 27g, Myrrha (processed) 22g, Radix Salviae Miltiorrhizae 145g, Flos Carthami 55g, Radix Notoginseng 95g, Rhizoma Chuanxiong 105g, Radix Aconiti Preparata 17g, Radix Aconiti Kusnezoffii Preparata 13g, Radix Clematidis 95g, Fructus Chaenomelis 105g, Radix Astragali 145g, Radix Angelicae Sinensis 105g, Radix Rehmanniae Preparata 155g, Eupolyphaga Seu Steleophaga 95g, Scorpio 55g, Pheretima 45g, Periostracum Serpentis (system) 105g, Radix Curcumae 155g, Rhizoma Wenyujin Concisum 17g, Radix Glycyrrhizae (processing) 45g.
Embodiment 4
Adopt the method for preparing watered pill of the present invention, the prescription of said medicine is: Rhizoma Drynariae (stir-fry) 140g, the Cortex Eucommiae (stir-fry) 98g, Radix Dipsaci (system) 103g, Radix Achyranthis Bidentatae 108g, Olibanum (system) 24g, Myrrha (processed) 20g, Radix Salviae Miltiorrhizae 153g, Flos Carthami 40g, Radix Notoginseng 90g, Rhizoma Chuanxiong 103g, Radix Aconiti Preparata 14g, Radix Aconiti Kusnezoffii Preparata 13g, Radix Clematidis 90g, Fructus Chaenomelis 102g, Radix Astragali 150g, Radix Angelicae Sinensis 108g, Radix Rehmanniae Preparata 145g, Eupolyphaga Seu Steleophaga 100g, Scorpio 40g, Pheretima 40g, Periostracum Serpentis (system) 100g, Radix Curcumae 145g, Rhizoma Wenyujin Concisum 25g, Radix Glycyrrhizae (processing) 47g.
Embodiment 5
Adopt the method for preparing watered pill of the present invention, the prescription of said medicine is: Rhizoma Drynariae (stir-fry) 145g, the Cortex Eucommiae (stir-fry) 105g, Radix Dipsaci (system) 98g, Radix Achyranthis Bidentatae 105g, Olibanum (system) 22g, Myrrha (processed) 25g, Radix Salviae Miltiorrhizae 160g, Flos Carthami 45g, Radix Notoginseng 110g, Rhizoma Chuanxiong 100g, Radix Aconiti Preparata 15g, Radix Aconiti Kusnezoffii Preparata 20g, Radix Clematidis 105g, Fructus Chaenomelis 108g, Radix Astragali 155g, Radix Angelicae Sinensis 110g, Radix Rehmanniae Preparata 160g, Eupolyphaga Seu Steleophaga 105g, Scorpio 45g, Pheretima 53g, Periostracum Serpentis (system) 95g, Radix Curcumae 155g, Rhizoma Wenyujin Concisum 25g, Radix Glycyrrhizae (processing) 60g.
Embodiment 6
Adopt the method for preparing watered pill of the present invention, the prescription of said medicine is: Rhizoma Drynariae (stir-fry) 148g, the Cortex Eucommiae (stir-fry) 95g, Radix Dipsaci (system) 110g, Radix Achyranthis Bidentatae 103g, Olibanum (system) 25g, Myrrha (processed) 24g, Radix Salviae Miltiorrhizae 140g, Flos Carthami 58g, Radix Notoginseng 95g, Rhizoma Chuanxiong 110g, Radix Aconiti Preparata 20g, Radix Aconiti Kusnezoffii Preparata 18g, Radix Clematidis 95g, Fructus Chaenomelis 105g, Radix Astragali 160g, Radix Angelicae Sinensis 105g, Radix Rehmanniae Preparata 140g, Eupolyphaga Seu Steleophaga 110g, Scorpio 50g, Pheretima 55g, Periostracum Serpentis (system) 110g, Radix Curcumae 160g, Rhizoma Wenyujin Concisum 15g, Radix Glycyrrhizae (processing) 45g.
Embodiment 7
Adopt the method for preparing watered pill of the present invention, the prescription of said medicine is: Rhizoma Drynariae (stir-fry) 155g, the Cortex Eucommiae (stir-fry) 90g, Radix Dipsaci (system) 95g, Radix Achyranthis Bidentatae 110g, Olibanum (system) 20g, Myrrha (processed) 26g, Radix Salviae Miltiorrhizae 155g, Flos Carthami 60g, Radix Notoginseng 105g, Rhizoma Chuanxiong 90g, Radix Aconiti Preparata 15g, Radix Aconiti Kusnezoffii Preparata 16g, Radix Clematidis 98g, Fructus Chaenomelis 98g, Radix Astragali 158g, Radix Angelicae Sinensis 90g, Radix Rehmanniae Preparata 152g, Eupolyphaga Seu Steleophaga 90g, Scorpio 44g, Pheretima 60g, Periostracum Serpentis (system) 105g, Radix Curcumae 150g, Rhizoma Wenyujin Concisum 16g, Radix Glycyrrhizae (processing) 40g.
Embodiment 8
Adopt the method for preparing watered pill of the present invention, the prescription of said medicine is: Rhizoma Drynariae (stir-fry) 157g, the Cortex Eucommiae (stir-fry) 103g, Radix Dipsaci (system) 105g, Radix Achyranthis Bidentatae 90g, Olibanum (system) 30g, Myrrha (processed) 30g, Radix Salviae Miltiorrhizae 150g, Flos Carthami 55g, Radix Notoginseng 107g, Rhizoma Chuanxiong 98g, Radix Aconiti Preparata 12g, Radix Aconiti Kusnezoffii Preparata 14g, Radix Clematidis 108g, Fructus Chaenomelis 95g, Radix Astragali 145g, Radix Angelicae Sinensis 95g, Radix Rehmanniae Preparata 158g, Eupolyphaga Seu Steleophaga 95g, Scorpio 55g, Pheretima 44g, Periostracum Serpentis (system) 90g, Radix Curcumae 152g, Rhizoma Wenyujin Concisum 30g, Radix Glycyrrhizae (processing) 50g.
Embodiment 9
Adopt the method for preparing watered pill of the present invention, the prescription of said medicine is: Rhizoma Drynariae (stir-fry) 143g, the Cortex Eucommiae (stir-fry) 92g, Radix Dipsaci (system) 90g, Radix Achyranthis Bidentatae 95g, Olibanum (system) 26g, Myrrha (processed) 23g, Radix Salviae Miltiorrhizae 142g, Flos Carthami 53g, Radix Notoginseng 100g, Rhizoma Chuanxiong 95g, Radix Aconiti Preparata 10g, Radix Aconiti Kusnezoffii Preparata 10g, Radix Clematidis 102g, Fructus Chaenomelis 90g, Radix Astragali 150g, Radix Angelicae Sinensis 100g, Radix Rehmanniae Preparata 150g, Eupolyphaga Seu Steleophaga 100g, Scorpio 48g, Pheretima 50g, Periostracum Serpentis (system) 93g, Radix Curcumae 148g, Rhizoma Wenyujin Concisum 23g, Radix Glycyrrhizae (processing) 53g.
Embodiment 10
Adopt the method for preparing watered pill of the present invention, the prescription of said medicine is: Rhizoma Drynariae (stir-fry) 155g, the Cortex Eucommiae (stir-fry) 105g, Radix Dipsaci (system) 95g, Radix Achyranthis Bidentatae 95g, Olibanum (system) 22g, Myrrha (processed) 27g, Radix Salviae Miltiorrhizae 155g, Flos Carthami 45g, Radix Notoginseng 105g, Rhizoma Chuanxiong 95g, Radix Aconiti Preparata 13g, Radix Aconiti Kusnezoffii Preparata 17g, Radix Clematidis 105g, Fructus Chaenomelis 95g, Radix Astragali 155g, Radix Angelicae Sinensis 95g, Radix Rehmanniae Preparata 145g, Eupolyphaga Seu Steleophaga 105g, Scorpio 45g, Pheretima 55g, Periostracum Serpentis (system) 95g, Radix Curcumae 144g, Rhizoma Wenyujin Concisum 25g, Radix Glycyrrhizae (processing) 55g.
In order to prove the therapeutic effect of ointment of the present invention, carry out following experiment
One, toxicity test
Chinese medicine composition of the present invention is a kind ofly can treat femur head necrosis, hyperosteogeny, various traumatic injury and arthritic special effect Chinese preparation, and the existing watered pill that makes with embodiment 1 is an example, carries out studies on acute toxicity.
, experiment material
The watered pill that 1.1 medicine: embodiment 1 is made, trade name bone growth promoting ball.
1.2 animal: mice, the Kunming kind, body weight 18-22 gram, male and female are usefulness all, available from Shandong Lu Yuan branch company of anti-medical group Experimental Animal Center.
, method and result
Get 10 of body weight 18-22 gram kunming mices, male and female half and half are once irritated these article of stomach 33mg/10 gram, and normal the raising observed seven days.
The result: the animal feed, drinking-water, fur, extremity activity and behavior etc. are all no abnormal, and weight increase dissects the naked eyes sight to wipe, the main organs no abnormality seen.
, brief summary and discussion
These article are once irritated stomach 33mg/10 gram; See to wipe and this is had any toxic reaction less than animal; Because receiving preparation and perfusion approach consumption limits; Irritate stomach and can't obtain the median lethal dose(LD 50) of mice, can only calculate roughly that it is more than the 33mg/10g that mice is once irritated the maximum tolerated dose of stomach bone growth promoting ball (MTO) the bone growth promoting ball.This dosage calculates by kg body weight, be equivalent to people's dose 100 surplus times, the medicine of embodiment 1 is safe without toxic side effect under oral situation.
It is also no abnormal that prepared medicine carries out toxicity test in other scope of the invention.
Two, zoopery
1, case source
1076 patients of this city various big hospital random choose as the drug use volunteer, wherein hyperosteogeny patient 312 examples, femur head necrosis patient's 280 examples, traumatic injury patient patient 260 examples, arthritis 224 examples.Wherein, 638 of male patients, 438 of female patients, patient age is between 35-65 year, and patient's mild or moderate, moderate, the severe state of an illness all have, and the severe state of an illness accounts for 20-30%, state of an illness judgment basis country relevant regulations.
, experimental technique
The hyperosteogeny patient is equally divided into four groups according to sex, age, the state of an illness, first group of medicine that uses embodiment 1, second group of medicine that uses embodiment 2, the 3rd group of medicine that uses embodiment 3, the 4th group of medicine that uses embodiment 4.Femur head necrosis patient, traumatic injury patient, arthritic also divide into groups and dispenser according to the method described above.
, application method
The medicine of the embodiment 1-4 that will make according to the inventive method is granted the patient respectively, and application method is each 5g, 2 times on the one.
, criterion
Produce effects: use after one month state of an illness recovery from illness or obviously alleviation, transference cure or basic disappearances such as pain, numbness, swelling;
Effectively: use after one month, the state of an illness is alleviated to some extent, and symptoms such as pain, numbness, swelling obviously alleviate;
Invalid: use after one month, the state of an illness does not have alleviation or the state of an illness increases the weight of.
, experimental result
6, experiment conclusion
Can find out that from above-mentioned experimental result medicine of the present invention all has good therapeutic effect to hyperosteogeny, femur head necrosis, traumatic injury, arthritis, and this cured substance time is short, to the equal onset of most patients, effective percentage is high.
Medicine in all protection domains of the present invention all can play good therapeutical effect, and above-mentioned only is to have enumerated a part of experimental data, and the therapeutic effect of other embodiment is with above-mentioned similar.

Claims (6)

1. Chinese medicine composition of treating orthopaedic disease, the composition that it is characterized in that crude drug is following composition:
Fry Rhizoma Drynariae 140-160g; Cortex Eucommiae (parched) 90-110g; System Radix Dipsaci 90-110g; Radix Achyranthis Bidentatae 90-110g; Olibanum (processed) 20-30g; Myrrha (processed) 20-30g; Radix Salviae Miltiorrhizae 140-160g; Flos Carthami 40-60g; Radix Notoginseng 90-110g; Rhizoma Chuanxiong 90-110g; Radix Aconiti Preparata 10-20g; Radix Aconiti Kusnezoffii Preparata 10-20g; Radix Clematidis 90-110g; Fructus Chaenomelis 90-110g; Radix Astragali 140-160g; Radix Angelicae Sinensis 90-110g; Radix Rehmanniae Preparata 140-160g; Eupolyphaga Seu Steleophaga 90-110g; Scorpio 40-60g; Pheretima 40-60g; System Periostracum Serpentis 90-110g; Radix Curcumae 140-160g; Rhizoma Wenyujin Concisum 15-30g; Radix Glycyrrhizae Preparata 40-60g.
2. Chinese medicine composition according to claim 1, the composition that it is characterized in that crude drug is following composition:
Fry Rhizoma Drynariae 160g, Cortex Eucommiae (parched) 103g, system Radix Dipsaci 105g, Radix Achyranthis Bidentatae 90g, Olibanum (processed) 30g, Myrrha (processed) 30g, Radix Salviae Miltiorrhizae 150g, Flos Carthami 55g, Radix Notoginseng 107g, Rhizoma Chuanxiong 98g, Radix Aconiti Preparata 12g, Radix Aconiti Kusnezoffii Preparata 14g, Radix Clematidis 108g, Fructus Chaenomelis 95g, Radix Astragali 160g, Radix Angelicae Sinensis 95g, Radix Rehmanniae Preparata 158g, Eupolyphaga Seu Steleophaga 95g, Scorpio 60g, Pheretima 44g, system Periostracum Serpentis 90g, Radix Curcumae 152g, Rhizoma Wenyujin Concisum 30g, Radix Glycyrrhizae Preparata 50g.
3. Chinese medicine composition according to claim 1, the composition that it is characterized in that crude drug is following composition:
Fry Rhizoma Drynariae 145-155g; Cortex Eucommiae (parched) 95-105g; System Radix Dipsaci 95-105g; Radix Achyranthis Bidentatae 95-105g; Olibanum (processed) 22-27g; Myrrha (processed) 22-27g; Radix Salviae Miltiorrhizae 145-155g; Flos Carthami 45-55g; Radix Notoginseng 95-105g; Rhizoma Chuanxiong 95-105g; Radix Aconiti Preparata 13-17g; Radix Aconiti Kusnezoffii Preparata 13-17g; Radix Clematidis 95-105g; Fructus Chaenomelis 95-105g; Radix Astragali 145-155g; Radix Angelicae Sinensis 95-105g; Radix Rehmanniae Preparata 145-155g; Eupolyphaga Seu Steleophaga 95-105g; Scorpio 45-55g; Pheretima 45-55g; System Periostracum Serpentis 95-105g; Radix Curcumae 145-155g; Rhizoma Wenyujin Concisum 17-25g; Radix Glycyrrhizae Preparata 45-55g.
4. Chinese medicine composition according to claim 1, the composition that it is characterized in that crude drug is following composition:
Fry Rhizoma Drynariae 150g, Cortex Eucommiae (parched) 100g, system Radix Dipsaci 100g, Radix Achyranthis Bidentatae 100g, Olibanum (processed) 25g, Myrrha (processed) 25g, Radix Salviae Miltiorrhizae 150g, Flos Carthami 50g, Radix Notoginseng 100g, Rhizoma Chuanxiong 100g, Radix Aconiti Preparata 15g, Radix Aconiti Kusnezoffii Preparata 15g, Radix Clematidis 100g, Fructus Chaenomelis 100g, Radix Astragali 150g, Radix Angelicae Sinensis 100g, Radix Rehmanniae Preparata 150g, Eupolyphaga Seu Steleophaga 100g, Scorpio 50g, Pheretima 50g, system Periostracum Serpentis 100g, Radix Curcumae 150g, Rhizoma Wenyujin Concisum 20g, Radix Glycyrrhizae Preparata 50g.
5. according to each described Chinese medicine composition among the claim 1-4, it is characterized in that: dosage form is the watered pill.
6. the method for preparing of the Chinese medicine composition of the described treatment orthopaedic disease of claim 5 is characterized in that: 20 four Chinese medicine thing pulverize separately being become fine powder, sieve then, mixing, is binding agent with water, processes the watered pill through general method for making.
CN2011101067698A 2011-04-27 2011-04-27 Chinese medicine composition for treating orthopedic disorders and preparation method thereof CN102178895B (en)

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CN104623050B (en) * 2015-02-10 2016-01-06 美亚药业海安有限公司 A kind of medicament for the treatment of corticosteroid femur head necrosis
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CN106390009A (en) * 2016-05-24 2017-02-15 张�杰 Traditional Chinese medicine for treating femur head necrosis
CN105944007A (en) * 2016-07-13 2016-09-21 江传国 TraditionalChinese medicine composition for treating traumatic injury
CN106038712A (en) * 2016-08-11 2016-10-26 温州医科大学附属第二医院 Traditional Chinese medicinal preparation for treating orthopedic diseases, and preparation method and application thereof
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CN109395036A (en) * 2018-09-10 2019-03-01 李友廷 A kind of Wen Yang exempts from numbness pharmaceutical composition and preparation method thereof, preparation and application
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1319414A (en) * 2001-01-19 2001-10-31 刘军 Medicine for treating hecrosis of femoral head
CN1686314A (en) * 2005-03-21 2005-10-26 锦州九天药业有限责任公司 Chinese medicinal preparation for treating cervical vertebra disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1319414A (en) * 2001-01-19 2001-10-31 刘军 Medicine for treating hecrosis of femoral head
CN1686314A (en) * 2005-03-21 2005-10-26 锦州九天药业有限责任公司 Chinese medicinal preparation for treating cervical vertebra disease

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
王恩厚.辨证论治风湿病.《河北中医》.2003,第25卷(第4期),278-279. *
秦明芳,等.明清三部骨伤科代表方书用药统计分析.《中国中医骨伤科杂志》.2007,第15卷(第8期),64-67. *

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