CN111298099A - Iron-supplementing composition and preparation method and application thereof - Google Patents
Iron-supplementing composition and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a preparation method and application of an iron supplement composition. The composition comprises active ingredients including sodium iron chlorophyllin, faeces Bombycis, Scutellariae radix, radix Angelicae sinensis, herba et Gemma Agrimoniae, radix Paeoniae alba, radix Codonopsis, Eucommiae cortex, Glycyrrhrizae radix, and vitamin B2Vitamin B6Vitamin B12Vitamin A, vitamin C, and polyoxin. The composition has the effects of supplementing various nutrients to the body, preventing iron-deficiency anemia, enhancing the immune function of the body and the like. The composition can be used for preventing the iron-deficiency anemia of the piglets, promoting the hematopoietic function of the organism, improving the immunity, inhibiting the diarrhea and the like of the piglets; it can also be used for improving egg quality of egg, increasing Ha's unit, and increasing eggshell strength and thickness. The composition has the advantages of wide raw material source, safety, stability, high efficiency, simple preparation process, low production cost and the like.
Description
Technical Field
The invention relates to a preparation method and application of an iron supplement composition, and belongs to the field of veterinary medicines.
Background
Iron is one of important trace elements in animal blood, participates in oxygen transportation and storage, and is an important element necessary for the rapid development of piglets after birth and for maintaining body metabolism and physiological activities. Because the weaned piglets have large food intake and relatively high nutritional requirement, the iron content in the bodies of the weaned piglets is generally low at this stage, the body weight and the volume of blood erythrocytes are rapidly increased, and the iron requirement is large. Therefore, if the iron content in the pig body is insufficient and deficient, iron-deficiency anemia, growth retardation, physical strength reduction, immunity reduction and the like can be caused, diseases such as piglet diarrhea and the like can be caused seriously, even the death of piglets can be caused, and huge economic loss is brought to the breeding industry. The iron supplement for the poultry can obviously promote the growth of the chicks, improve the production performance and the immune oxidation resistance level of the poultry, and improve the egg laying performance and the iron content in the eggs of the laying hens.
At present, most of intramuscular injection iron supplement compositions in the market are mainly composed of iron dextran, when the compositions are injected, piglets are easy to be stimulated, and injection parts of the piglets are easy to be bruised and swollen. The iron-containing additive used in the feed at present mainly comprises three generations of products, the first generation of product is inorganic salt iron, such as ferrous sulfate, and the iron-containing additive is characterized by strong stimulation to stomach, poor palatability and low utilization rate; the second generation product is organic ferric salt, such as ferrous fumarate, and is characterized by decomposition in stomach, unstable property, low absorption rate, palatability slightly superior to inorganic iron, and low utilization rate; the third generation product is amino acid chelated iron and small peptide chelated iron, such as glycine iron, and has the characteristics of good palatability, high utilization rate and many factors influencing the absorption effect.
The product of the invention is a fourth-generation iron supplement product, the main component of which is sodium iron chlorophyllin, and the product is called as pig iron imitation because the chemical structure of the product is similar to that of heme iron. Its advantages are high absorption speed, high utilization rate, high stability and palatability, no participation in iron ions and no influence by organism environment. Compared with the previous three generations of products, the product of the invention has many incomparable advantages and is widely applied abroad, but is just started in China, is mainly used for human medicine, and has few test reports particularly in the animal husbandry and the pig raising industry.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a safe, stable and efficient iron supplement composition.
It is another object of the present invention to provide a method for preparing the iron supplement composition.
The iron supplement composition provided by the invention contains active ingredients, wherein the active ingredients comprise sodium iron chlorophyllin, silkworm excrement, scutellaria baicalensis, angelica sinensis, hairyvein agrimony, white paeony root, codonopsis pilosula, eucommia ulmoides, liquorice and vitamin B2Vitamin B6Vitamin B12Vitamin A, vitamin C and polyoxin.
The active ingredients comprise 60-140 parts of sodium iron chlorophyllin, 30-70 parts of silkworm excrement, 5-15 parts of scutellaria baicalensis, 10-20 parts of angelica sinensis, 10-20 parts of hairyvein agrimonia herb and bud, 10-20 parts of white paeony root, 10-50 parts of codonopsis pilosula, 10-20 parts of eucommia ulmoides, 3-10 parts of liquorice and vitamin B22-8 parts of vitamin B61-5 parts of vitamin B120.01-0.3 part, 1-10 parts of vitamin A, 30-80 parts of vitamin C and 1-20 parts of polyoxin.
Further, the active ingredients comprise 80-120 parts of sodium iron chlorophyllin, 40-60 parts of silkworm excrement, 7-12 parts of scutellaria baicalensis, 12-17 parts of angelica sinensis, 12-17 parts of hairyvein agrimonia herb and bud, 12-17 parts of white paeony root, 20-40 parts of codonopsis pilosula, 12-17 parts of eucommia ulmoides, 4-7 parts of liquorice, and vitamin B23-6 parts of vitamin B62-4 parts of vitamin B120.1-0.25 part, 4-7 parts of vitamin A, 40-60 parts of vitamin C and 5-15 parts of polyoxin.
Further, the active ingredients comprise 100 parts of sodium iron chlorophyllin, 50 parts of silkworm excrement, 10 parts of scutellaria baicalensis, 15 parts of angelica, 15 parts of hairyvein agrimony, 15 parts of white paeony root, 30 parts of codonopsis pilosula, 15 parts of eucommia ulmoides, 6 parts of liquorice and vitamin B25 portions of vitamin B63 portions of vitamin B120.2 part, 6 parts of vitamin A, 50 parts of vitamin C and 10 parts of polyoxin.
The invention also provides a preparation method of the iron supplement composition, which comprises the following steps:
(1) weighing sodium iron chlorophyllin and vitamin B according to weight ratio2Vitamin B6Vitamin B12Vitamin A, vitamin C and polyoxin are taken as a component 1;
(2) weighing faeces Bombycis, Scutellariae radix, radix Angelicae sinensis, herba et Gemma Agrimoniae, radix Paeoniae alba, radix Codonopsis, Eucommiae cortex, and Glycyrrhrizae radix as component 2;
(3) pulverizing the weighed component 2, sieving, or extracting the weighed component 2 with water or alcohol, concentrating, adding the component 1, mixing, and adding pharmaceutically acceptable adjuvants or auxiliary components.
The dosage form of the iron supplement composition prepared by the preparation method can be as follows: premix, powder, tablet, granule, and oral liquid.
The components and amounts thereof in the compositions of the present invention are based on a large number of repeated practices. The composition can be used for preventing the iron-deficiency anemia of the piglets, promoting the hematopoietic function of the body and improving the immunity; can also be used for improving the production performance of poultry, improving the egg quality of eggs, and the like. The composition is prepared into a preparation which is commonly used in pharmacy and mainly treats iron deficiency anemia of livestock and poultry. The composition can also be added into feed to prepare the feed for preventing the iron-deficiency anemia of the livestock and poultry.
The composition has the advantages and beneficial effects that:
(1) the composition can effectively improve the production performance of sows, improve the birth weight and the survival rate of piglets, improve the hemoglobin content in the blood of the piglets, enhance the immunity of organisms and effectively prevent and treat the iron-deficiency anemia of the piglets;
(2) the composition can effectively improve the average egg laying rate, improve the average egg weight, increase the thickness and the strength of the eggshell, reduce the egg breaking rate and improve the iron content in the eggs.
(3) The composition can effectively improve the growth performance of the broilers, increase the weight of the broilers, reduce the feed conversion ratio, improve the survival rate and improve the immune function and disease resistance of the broilers.
(4) The composition has the advantages of wide raw material source, safety, stability, high efficiency, simple preparation process, low production cost and the like.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
EXAMPLE 1 preparation and use of compositions of the invention
(1) Weighing the following raw materials by weight:
60 parts of sodium iron chlorophyllin, 30 parts of silkworm excrement, 5 parts of scutellaria baicalensis, 10 parts of angelica sinensis, 10 parts of hairyvein agrimonia herb and bud, 10 parts of white paeony root, 10 parts of codonopsis pilosula, 10 parts of eucommia ulmoides, 3 parts of liquorice and vitamin B22 portions of vitamin B61 part of vitamin B120.01 part, 1 part of vitamin A, 30 parts of vitamin C and 1 part of polyoxin.
(2) Pulverizing faeces Bombycis, Scutellariae radix, radix Angelicae sinensis, herba et Gemma Agrimoniae, radix Paeoniae alba, radix Codonopsis, Eucommiae cortex, and Glycyrrhrizae radix, sieving, and adding sodium iron chlorophyllin and vitamin B2Vitamin B6Vitamin B12Vitamin A, vitamin C and polyoxin are fully and uniformly mixed to prepare powder.
(3) The use method of the composition comprises the following steps: can be used for preventing and treating pig iron deficiency anemia, promoting organism hemopoiesis, enhancing immunity, and improving poultry production performance. Mixed feeding: the composition of the invention is added into the feed of each 1kg of the livestock, and 0.5-1g of the composition is added into the feed of each 1kg of the livestock; the composition of the invention is added into poultry per 1kg of feed by 0.25-0.5 g.
Example 2 preparation and use of compositions of the invention
(1) Weighing the following raw materials by weight:
140 parts of sodium iron chlorophyllin, 70 parts of silkworm excrement, 15 parts of scutellaria baicalensis, 20 parts of angelica sinensis, 20 parts of hairyvein agrimonia herb and bud, 20 parts of white paeony root, 50 parts of codonopsis pilosula, 20 parts of eucommia ulmoides, 10 parts of liquorice and vitamin B28 portions of vitamin B65 portions of vitamin B120.3 part, 10 parts of vitamin A, 80 parts of vitamin C and 20 parts of polyoxin.
(2) Pulverizing faeces Bombycis, Scutellariae radix, radix Angelicae sinensis, herba et Gemma Agrimoniae, radix Paeoniae alba, radix Codonopsis, Eucommiae cortex, and Glycyrrhrizae radix, and mixingSoaking the raw materials in distilled water for 30min, decocting for 3 times (each time for 1.5 hr), mixing filtrates, concentrating into thick paste, adding sodium ferrous chlorophyllin and vitamin B2Vitamin B6Vitamin B12Vitamin A, vitamin C and polyoxin, finally adding a proper amount of starch and dextrin (or other auxiliary materials), uniformly mixing, preparing a soft material, granulating, and drying to prepare granules (each 1g of the granules is equal to 1g of the raw material).
(3) The use method of the composition comprises the following steps: can be used for preventing and treating pig iron deficiency anemia, promoting organism hemopoiesis, enhancing immunity, and improving poultry production performance. Mixing and drinking: the composition of the invention is added into 1L of water for livestock and poultry, 0.5g, and the composition is freely drunk.
Example 3 preparation and use of compositions of the invention
(1) Weighing the following raw materials by weight:
80 parts of sodium iron chlorophyllin, 40 parts of silkworm excrement, 7 parts of scutellaria baicalensis, 12 parts of angelica sinensis, 12 parts of hairyvein agrimony, 12 parts of white paeony root, 20 parts of codonopsis pilosula, 12 parts of eucommia ulmoides, 4 parts of liquorice and vitamin B23 portions of vitamin B62 portions of vitamin B120.1 part, 4 parts of vitamin A, 40 parts of vitamin C and 5 parts of polyoxin.
(2) Pulverizing faeces Bombycis, Scutellariae radix, radix Angelicae sinensis, herba et Gemma Agrimoniae, radix Paeoniae alba, radix Codonopsis, Eucommiae cortex, and Glycyrrhrizae radix, soaking the medicinal materials in distilled water for 30min, decocting for 3 times, each for 1.5 hr, mixing filtrates, concentrating into thick paste, adding sodium iron chlorophyllin and vitamin B2Vitamin B6Vitamin B12Vitamin A, vitamin C and polyoxin, finally adding a proper amount of starch and dextrin (or other auxiliary materials), uniformly mixing, preparing a soft material, granulating, and drying to prepare granules (each 1g of the granules is equal to 1g of the raw material).
(3) The use method of the composition comprises the following steps: can be used for preventing and treating pig iron deficiency anemia, promoting organism hemopoiesis, enhancing immunity, and improving poultry production performance. Mixing and drinking: the composition of the invention is added into 1L of water for livestock and poultry, 0.5g, and the composition is freely drunk.
Example 4 preparation and use of compositions of the invention
(1) Weighing the following raw materials by weight:
120 parts of sodium iron chlorophyllin, 60 parts of silkworm excrement, 12 parts of scutellaria baicalensis, 17 parts of angelica sinensis, 17 parts of hairyvein agrimony, 17 parts of white paeony root, 40 parts of codonopsis pilosula, 17 parts of eucommia ulmoides, 7 parts of liquorice and vitamin B26 portions of vitamin B64 parts of vitamin B120.25 part, 7 parts of vitamin A, 60 parts of vitamin C and 15 parts of polyoxin.
(2) Pulverizing faeces Bombycis, Scutellariae radix, radix Angelicae sinensis, herba et Gemma Agrimoniae, radix Paeoniae alba, radix Codonopsis, Eucommiae cortex, and Glycyrrhrizae radix, soaking the materials in distilled water for 30min, decocting for 3 times, each for 1.5 hr, mixing filtrates, and concentrating to a certain volume (equivalent to 0.5g/ml of original medicine); adding ethanol until ethanol content in the filtrate is 70%, filtering, recovering ethanol from the filtrate, adding sodium ferrous chlorophyllin and vitamin B2Vitamin B6Vitamin B12Vitamin A, vitamin C and polyoxin A, filtering, encapsulating, sterilizing and finally preparing into oral liquid (each 1ml is equivalent to 0.5g of the raw material).
(3) The use method of the composition comprises the following steps: can be used for preventing and treating pig iron deficiency anemia, promoting organism hemopoiesis, enhancing immunity, and improving poultry production performance. Mixing and drinking: 1g of the composition is added into 1L of water for livestock and poultry, and the composition is freely drunk; or drenching: 0.2ml/kg of livestock and poultry.
Example 5 preparation and use of compositions of the invention
(1) Weighing the following raw materials by weight:
100 parts of sodium iron chlorophyllin, 50 parts of silkworm excrement, 10 parts of scutellaria baicalensis, 15 parts of angelica sinensis, 15 parts of hairyvein agrimonia herb and bud, 15 parts of white paeony root, 30 parts of codonopsis pilosula, 15 parts of eucommia ulmoides, 6 parts of liquorice and vitamin B25 portions of vitamin B63 portions of vitamin B120.2 part, 6 parts of vitamin A, 50 parts of vitamin C and 10 parts of polyoxin.
(2) Pulverizing faeces Bombycis, Scutellariae radix, radix Angelicae sinensis, herba et Gemma Agrimoniae, radix Paeoniae alba, radix Codonopsis, Eucommiae cortex, and Glycyrrhrizae radix, soaking the materials in distilled water for 30min, decocting for 3 times, each for 1.5 hr, mixing filtrates, and concentrating to a certain volume (equivalent to 0.5g/ml of original medicine); adding ethanol until the ethanol content in the filtrate is 70%, and filteringRecovering ethanol from the filtrate, adding sodium iron chlorophyllin and vitamin B2Vitamin B6Vitamin B12Vitamin A, vitamin C and polyoxin A, filtering, encapsulating, sterilizing and finally preparing into oral liquid (each 1ml is equivalent to 0.5g of the raw material).
(3) The use method of the composition comprises the following steps: can be used for preventing and treating pig iron deficiency anemia, promoting organism hemopoiesis, enhancing immunity, and improving poultry production performance. Mixing and drinking: 1g of the composition is added into 1L of water for livestock and poultry, and the composition is freely drunk; or drenching: 0.2ml/kg of livestock and poultry.
Example 6 preparation and use of compositions of the invention
(1) Weighing the following raw materials by weight:
140 parts of sodium iron chlorophyllin, 60 parts of silkworm excrement, 15 parts of scutellaria baicalensis, 15 parts of angelica sinensis, 15 parts of hairyvein agrimony, 15 parts of white paeony root, 50 parts of codonopsis pilosula, 10 parts of eucommia ulmoides, 3 parts of liquorice and vitamin B25 portions of vitamin B63 portions of vitamin B120.2 part, 5 parts of vitamin A, 50 parts of vitamin C and 15 parts of polyoxin.
(2) Pulverizing faeces Bombycis, Scutellariae radix, radix Angelicae sinensis, herba et Gemma Agrimoniae, radix Paeoniae alba, radix Codonopsis, Eucommiae cortex, and Glycyrrhrizae radix, soaking the medicinal materials in distilled water for 30min, decocting for 3 times, each time for 1.5 hr, mixing filtrates, concentrating to a certain volume (equivalent to 1g/ml of original medicine), adding ethanol until ethanol content in filtrate is 70%, filtering, recovering ethanol from filtrate, adding sodium iron chlorophyllin and vitamin B2Vitamin B6Vitamin B12Mixing vitamin A, vitamin C and polyoxin, adding appropriate amount of starch and dextrin (or other adjuvants), mixing, adding magnesium stearate, mixing, granulating, and tabletting to obtain tablet of 0.2g (1 g is 2g of the raw material).
(3) The use method of the composition comprises the following steps: can be used for preventing and treating pig iron deficiency anemia, promoting organism hemopoiesis, enhancing immunity, and improving poultry production performance. 5-10 slices of pig; 1-2 tablets for rabbit and bird.
Example 7 preparation and use of compositions of the invention
(1) Weighing the following raw materials by weight:
120 parts of sodium iron chlorophyllin, 50 parts of silkworm excrement, 5 parts of scutellaria baicalensis, 5 parts of angelica sinensis, 10 parts of hairyvein agrimonia herb and bud, 10 parts of white paeony root, 10 parts of codonopsis pilosula, 10 parts of eucommia ulmoides, 3 parts of liquorice and vitamin B26 portions of vitamin B64 parts of vitamin B120.3 part, 7 parts of vitamin A, 60 parts of vitamin C and 15 parts of polyoxin.
(2) Pulverizing faeces Bombycis, Scutellariae radix, radix Angelicae sinensis, herba et Gemma Agrimoniae, radix Paeoniae alba, radix Codonopsis, Eucommiae cortex, and Glycyrrhrizae radix, sieving, and adding sodium iron chlorophyllin and vitamin B2Vitamin B6Vitamin B12Vitamin A, vitamin C and polyoxin are fully and uniformly mixed to prepare powder.
(3) The use method of the composition comprises the following steps: can be used for preventing and treating pig iron deficiency anemia, promoting organism hemopoiesis, enhancing immunity, and improving poultry production performance. Mixed feeding: the composition of the invention is added into the feed of each 1kg of the livestock, and 0.5-1g of the composition is added into the feed of each 1kg of the livestock; the composition of the invention is added into poultry per 1kg of feed by 0.25-0.5 g.
Example 8 preparation and use of compositions of the invention
(1) Weighing the following raw materials by weight:
120 parts of sodium iron chlorophyllin, 30 parts of silkworm excrement, 15 parts of scutellaria baicalensis, 15 parts of angelica sinensis, 10 parts of hairyvein agrimonia herb and bud, 10 parts of white paeony root, 30 parts of codonopsis pilosula, 15 parts of eucommia ulmoides, 6 parts of liquorice and vitamin B28 portions of vitamin B65 portions of vitamin B120.3 part, 5 parts of vitamin A, 50 parts of vitamin C and 10 parts of polyoxin.
(2) Pulverizing faeces Bombycis, Scutellariae radix, radix Angelicae sinensis, herba et Gemma Agrimoniae, radix Paeoniae alba, radix Codonopsis, Eucommiae cortex, and Glycyrrhrizae radix, sieving, and adding sodium iron chlorophyllin and vitamin B2Vitamin B6Vitamin B12Vitamin A, vitamin C and polyoxin are fully and uniformly mixed to prepare powder.
(3) The use method of the composition comprises the following steps: can be used for preventing and treating pig iron deficiency anemia, promoting organism hemopoiesis, enhancing immunity, and improving poultry production performance. Mixed feeding: the composition of the invention is added into the feed of each 1kg of the livestock, and 0.5-1g of the composition is added into the feed of each 1kg of the livestock; the composition of the invention is added into poultry per 1kg of feed by 0.25-0.5 g.
In order to show the effects of the composition on improving the production performance of livestock and controlling iron-deficiency anemia of livestock and poultry, the composition is subjected to a clinical effect observation test, and the beneficial effects of the composition are further illustrated by test examples.
Test example 1:
1.1 test materials
In order to ensure the scientific nature of the test, the iron supplement composition of the present invention used in test example 1 was modified as follows: the components and proportions in examples 1, 2, 3, 4 and 5 were kept unchanged, but powders were prepared in unison for testing.
1.2 test animals and diets
75 sows (Changbai multiplied by Dabai) in the later period of pregnancy with good health condition, basically consistent gestation times after mating and mating date are selected and randomly divided into 5 groups, each group has 3 repetitions, each repetition has 5 pigs, piglets born by the test sows participate in the test together, and the piglets are weaned in 21 days. The test was divided into 6 groups including control group, test 1 group, test 2 group, test 3 group, test 4 group and test 5 group. The experimental design is as follows:
the basic feed mainly comprises corn-soybean meal. The sow diets were designed with reference to the pregnant sow requirements of NRC (1998) to remove any iron containing components, and the composition and nutritional levels are shown in table 2.
1.3 Breeding management
The feeding test is carried out in the West Hunan experiment base. The test sows are raised in a double-row delivery room, and enter the formal period at the 12 th week after the pregnancy of the test sows, namely 4 weeks before delivery, until 3 weeks after delivery, and the test lasts for 7 weeks. The sow is fed in limited amount, and is fed for 1 time in the morning and evening every day, and water is freely drunk. The feeding management and immunization procedures of the test sows and the suckling piglets are carried out according to the normal operating rules.
1.4 index determination
(1) The sow production performance index is as follows: average daily feed intake, average litter size, number of born alive, number of dead births and rate of alive births; (2) the piglet growth performance indexes are as follows: the birth weight, the weaned weight and the average daily gain of the piglets; (3) and (3) determining the hemoglobin content of the sows and piglets: blood of sows at the day of delivery and piglets at 1d and 21d is collected. And (4) performing fasting binding blood collection on the day of sow delivery and performing fixed blood collection on piglets at 1d and 21d of birth. 2mL of blood is collected from the ear root vein of each sow, 3 piglets are selected from each litter, and after fixation, 2mL of blood is collected from the anterior vena cava. After blood collection, the blood is immediately placed in a plasma anticoagulation tube for storage, and the hemoglobin content and the red blood cell number are measured in time.
1.5 data processing and analysis
The test data were analyzed using SPSS18.0 statistical software and multiple comparisons were performed using the Duncan's method. The results are all expressed as "mean ± standard deviation",P<the difference was significant at 0.05.
2 results and analysis
2.1 Effect of the iron supplement composition of the present invention on sow Productivity
As can be seen from the table, the average daily food intake of the sows was significantly improved in the test 2, test 3 and test 4 groups, compared with the control group, wherein the effect of the test 3 group was the best and improved by 3.41% (R) compared with the control groupP< 0.01). The average litter size between groups was not significantly different.
The litter size of the sows in the 3 groups can be obviously increased by 21.74 percent (compared with the control group, the 1 group, the 2 group, the 4 group and the 5 group in the testP＜0.05）、14.61%（P＜0.05）、14.36%（P＜0.05）、13.40%（P< 0.05) and 21.06%, (P< 0.05). The number of dead tires was reduced in each test group compared to the control group, wherein test 1 and test 5 had a tendency to decrease and test 2 and test 4 had a decrease of 38.30% respectively compared to the control group (P< 0.05) and 32.77%, (P< 0.05). The experiment 3 group has 62.55 percent of reduction compared with the control group (PLess than 0.01), the effect is most remarkable. The survival rate of each test group is improved to different degrees and is respectively improved by 5.23 percent, 0.36 percent, 9.38 percent, 6.53 percent and 4.61 percent compared with the control group.
The results show that the iron supplement composition of the invention with different levels is added into the daily ration of the sow in the later gestation period and the lactation period, so that the production performance of the sow can be improved, the number of dead piglets is reduced to a certain extent, the survival rate and the breeding rate of the piglets are improved, and the growth and development of the suckling piglets are guaranteed. Of these, test 3 had the best results.
2.2 Effect of the iron supplement composition of the present invention on the production Performance of suckling piglets
As can be seen from the table, the birth weight and the weaning weight of the piglets of each test group are higher than those of the piglets of the control group, wherein the birth weight and the weaning weight of the piglets of the test groups 2, 3 and 4 can be obviously improved, and the birth weight is respectively improved by 6.90 percent (compared with the birth weight and the weaning weight of the piglets of the control group)P＜0.05）、13.10%（P< 0.01) and 7.59% (PLess than 0.05), the weaning weight is respectively improved by 5.08 percent compared with that of a control group (P＜0.05）、9.83%（P< 0.05) and 5.93%, (P< 0.05). The average daily gain of each group is increased by 3.97 percent (respectively) compared with that of the control groupP>0.05）、10.41%（P＜0.05）、16.67%（P＜0.05）、11.51%（P< 0.05) and 7.24%, (P>0.05）。
The survival rate of weaned piglets in each group is obviously higher than that of the control group, wherein the effect of the 3 groups is most obvious, and the survival rate is improved by 5.97 percent (compared with the control group)PLess than 0.01), and the ratio of the test 4 group to the test 2 group is respectively increased by 3.74 percent (compared with the control group)P< 0.01) and 3.35%, (P< 0.01). Although the survival rate of the weaned piglets in the test 1 group and the test 5 group is lower than that in the test 2, the test 3 and the test 4 group, the survival rate is respectively improved by 1.61 percent (compared with that in the control group)P< 0.05) and 1.31%, (P＜0.05）。
Therefore, the iron supplement composition of the invention with different levels is added into the feed of the sow, so that the birth weight and the weaning weight of the piglets can be increased, and the survival rate of the weaned piglets is obviously improved. From the observation condition every day, the growth vigor of the piglets of the test group is more lively and happy, the fur is smooth, the skin is ruddy, the growth speed is high, the ill condition is less, and the uniformity is high.
2.3 Effect of the iron supplement composition of the present invention on the amount of hemoglobin and erythrocytes in the blood of sows
As can be seen from the table, each test group was able to increase the number of erythrocytes and the concentration of hemoglobin in the blood of sows to a different extent as compared with the control group. Among them, the red blood cell count and hemoglobin concentration of test 1 and test 5 groups showed an increasing trend, though they were not significantly different from the control group; the test 2 group and the test 4 group both obviously improve the number of red blood cells and the concentration of hemoglobin in the sow body; the effect of the test 3 group is best, and the red blood cells in the sow are 12.87 percent higher than that in the control group (the ratio of red blood cells to red blood cells is higher than that in the control group)P< 0.01), 9.45% higher than test 1, test 2, test 4 and test 5, respectively (P＜0.05）、3.58%（P＜0.05）、3.02%（P< 0.05) and 9.87%, (P< 0.05). The highest hemoglobin concentration in the blood of the sows in the test group 3 is 27.33 percent higher than that in the control group (P< 0.01), 22.42% higher than test 1, test 2, test 4 and test 5, respectively (P＜0.05）、11.62%（P＜0.05）、7.27%（P< 0.05) and 18.79%, (P＜0.05）。
2.4 Effect of the iron supplement composition of the present invention on the hemoglobin content of suckling piglets
As can be seen from the table, the hemoglobin numbers of the piglets in each test group at 1 day of age were increased to different degrees, wherein the hemoglobin number of the piglets in the test 3 groups was the highest and 18.10% higher than that in the control group (1 day of age)P< 0.01), secondlyAre test 2 and test 4
The hemoglobin number is 10.98% higher than that of the control group respectively (P< 0.01) and 10.17%, (P< 0.01). At the time of weaning at the age of 21 days, compared with a control group, the hemoglobin number of the weaned piglets is further obviously improved in each test group, wherein the hemoglobin number of the test group 3 is improved by 36.07% (36.07%) (compared with that of the control group)PLess than 0.01), the effect is most remarkable. The effect of the test 2 and the test 4 is inferior to that of the control group, and is improved by 27.02%, (P< 0.05) and 29.17%, (P< 0.05), the test 1 group and the test 5 group were respectively improved by 18.16% compared with the control group (P< 0.05) and 20.57%, (P＜0.05）。
The results show that the iron supplement composition added into the daily ration of the sows in the later gestation period and the lactation period has positive effects on improving the health condition of the sows and storing iron in vivo, so that the healthy growth of piglets is guaranteed.
Example 2
The test is carried out in a certain cooperative laying hen farm in Henan, 3 months, 2016, and the influence of the iron supplement composition on the laying hen production performance and the egg quality is mainly researched. Selecting healthy 32-week-old Hailan brown laying hens with 180 feathers and similar body weight, randomly dividing the 180 feathers into 3 groups, wherein each group has 3 repetitions, and each repetition has 20 feathers. The test was divided into control groups and fed on a basal diet, and the test groups added different levels of the iron supplement composition of the present invention to the basal diet, prepared using example 3. The addition amount of the test 1 group is 0.25 per mill of the iron supplement composition of the invention, and the addition amount of the test 2 group is 0.50 per mill of the iron supplement composition of the invention. The test period was 4 weeks. The test results are as follows:
the test result shows that compared with the control group, the addition of 0.25 per mill and 0.50 per mill of the iron supplement composition has a certain promotion effect on improving the production performance of the laying hens, and the average feed intake is respectively increased by 1.33 percent (the percentage is 1.33 percent)P> 0.05) and 1.76% ((1)P＞0.05）；The laying rate is respectively increased by 1.42%, (P> 0.05) and 1.51% ((II)P> 0.05); the average egg weight is respectively increased by 3.34%, (P< 0.05) and 3.46%, (P＜0.05); the feed-egg ratio is respectively reduced by 2.80% ((P< 0.05) and 3.27%, (P＜0.05）。
The test result shows that compared with the control group, the iron supplement composition of the invention added with 0.25 per mill and 0.50 per mill can improve the quality of eggs, and the Ha's unit shows the increasing trend which is respectively increased by 3.29 percent (P＞0.05) and 3.66%, (P＞0.05); the eggshell strength is respectively improved by 9.23%, (P< 0.05) and 11.91%, (P< 0.05); the thickness of the eggshell is respectively increased by 6.28%, (P< 0.05) and 8.01%, (P< 0.05); the specific gravity of the eggshell tends to increase.
The results are combined to show that the iron supplement composition has a gain effect on the production performance of the laying hens by adding the iron supplement composition into the daily ration of the laying hens, the average egg weight can be obviously improved, and the feed-egg ratio is obviously reduced; meanwhile, the egg quality of eggs can be improved, the Haw unit is improved, the eggshell strength and the eggshell thickness are increased, and the egg breaking rate is reduced.
Example 3
The test was carried out in the Hunan Black pig base in 2016, 8 months. 72 West Hunan black pigs in late gestation period (about 84 d) with the same gestation frequency, health, no disease and the same or similar body conditions are selected and randomly divided into 3 groups, each group has 3 repetitions, and each repetition has 8 repetitions. Feeding the control group with basic ration without adding any iron supplement; test 1 group an iron supplement composition of the present invention was added at 500 mg/kg to a basal diet, prepared using example 1; test 2 groups an iron supplement composition according to the invention was added at 1000 mg/kg to the basal diet, also prepared using example 1. The test sow enters the formal period at the 12 th week after pregnancy, namely 4 weeks before delivery, until the sow gives birth for 30 days. The feeding management and immunization procedures during the experiment were performed according to the routine procedures. The detection indexes comprise (1) reproductive performance indexes of sows: total litter size, live litter size, weak litter size (birth weight less than 0.9 kg), dead litter size, birth individual weight, and litter weight were accurately recorded for each sow. (2) The iron content index in the sow lactoferrin is as follows: milk (colostrum) of the sows was collected on the day of parturition. Collecting milk samples from front, middle and back 3 nipples, mixing, collecting 10mL each, and storing at-20 deg.C. The kit is used for measuring the contents of iron, ferritin (SF) and transferrin (SFI) in colostrum. (3) Hemoglobin content and red blood cell count of sow: blood of the day of delivery of the sow is collected. 2mL of blood is collected from the ear root vein of each sow, and the sow is immediately placed in a plasma anticoagulation tube for storage, and the hemoglobin content and the red blood cell number are measured. The test results are as follows:
as can be seen from the table, the total number born and the number alive of the test 1 group and the test 2 group are significantly improved compared with the control group, but no significant difference exists between the two groups; test 2 groups significantly reduced the number of dead births. There was no significant difference in weak litter size between groups. The survival rate of the test 1 group and the test 2 group is respectively improved by 6.82 percent and 11.46 percent compared with the control group. The weak litter size of the test 2 group was the lowest, and was reduced by 60.46% compared to the control group and 4.15% compared to the test 1 group. The average weight of the newborn young individuals in the test 2 group is improved by 13.53 percent compared with that in the control group (P< 0.05), the average weight of newborn animals in the test 1 group was increased by 7.52% as compared with the control group, and the trend was shown to be increased. The litter weight of the newborn piglets in the test 1 group and the test 2 group can be obviously improved and is respectively 16.26 percent higher than that of the control group (the weight of the newborn piglets in the test 1 group and the weight of the newborn piglets in the test 2 group is higher than that of the newborn piglets in the control group by (P< 0.05) and 21.63%, (P< 0.05). The results show that the iron supplement composition added into the daily ration of the sows can achieve good feeding effect, the reproductive performance of the sows is improved to a certain extent, and the survival rate and the health degree of piglets are improved.
As can be seen from the table, both test groups improved the iron content in the colostrum of the sows to a different extent compared to the control group, with test 2 having the best results, colostrum iron, ferritin and transferrinWhite is respectively increased by 55.83%, (P＜0.01）、85.87%（P< 0.01) and 52.69% ((R)P< 0.05). Secondly, in the test 1 group, the colostrum iron, the ferritin and the transferrin are respectively improved by 29.09% ((P＜0.05）、24.28%（P< 0.05) and 17.20%, (P> 0.05). It is shown that the iron supplement composition can improve the iron storage level in the sow.
As can be seen from the table, both test groups were able to increase the number of erythrocytes and the hemoglobin concentration in the blood of sows to a different extent than the control group, wherein the number of erythrocytes in test 2 group was increased by 11.33% compared to the control group (seeP< 0.05), the hemoglobin concentration is increased 23.49% compared with the control group (P> 0.05). The red blood cell count and hemoglobin of the test 1 group were increased by 7.23% compared to the control group, respectively (P＞0.05）、10.94%（P> 0.05). It is demonstrated that the iron supplement composition can increase the number of erythrocytes and the concentration of hemoglobin in the blood of sows.
Example 4:
the test was carried out in 2017 in a client farm in Shandong in 4 months. The influence of the iron supplement composition on the growth performance and iron nutrition of the weaned pigs is researched through experiments. 300 healthy weaned Du X long X big piglets with 28 days of age are selected, all piglets are divided into 3 groups according to the principle of similar weight, half of the male and female and single-factor experimental design, each group has 4 repetitions, and each repetition (column) has 25 repetitions. The control group was fed a basal diet (no iron source added), test 1 group was supplemented with 80mg/kg (as iron element) of a feed grade ferrous sulfate monohydrate preparation (feso 4. h2 o) on the basal diet, test 2 group was supplemented with 80mg/kg (as iron element) of a feed grade ferrous glycinate preparation (Fe-Gly) on the basal diet, and test 3 group was supplemented with 80mg/kg (as iron element) of the iron supplement composition of the present invention on the basal diet, prepared in example 7. The pre-test period is 7 days, and the normal test period is 28 days. The piglets are weighed one by one after fasting for 12h before the official test. And (4) after the test is finished, weighing the piglets on an empty stomach, and calculating the average daily gain, the average daily feed intake and the feed-weight ratio of the piglets. And blood samples of healthy piglets of each group are collected, and serum biochemical indexes of the piglets are measured. The test results are as follows:
as can be seen from the table, both test 2 and test 3 significantly improved the weight of the piglets at the end of the test compared to the control group, and the iron supplement composition of the present invention had the best feeding effect in test 3. The weight of the piglet powder in the experiment 3 group is respectively increased by 11.19 percent compared with that of the piglet powder in the control group, the piglet powder in the experiment 1 group and the piglet powder in the experiment 2 group (the weight of the piglet powder in the control group is increased by 11.19 percent byP＜0.01）、8.64%（P< 0.01) and 4.01%, (P< 0.05). Compared with a blank control group and a test 1 group, the average daily gain of piglets can be obviously improved in the test 2 group and the test 3 group, but the difference between the two groups is not obvious, and the test 3 group has an improvement trend compared with the test 2 group. The average daily food intake of piglets between groups was not significantly different. The material weight ratio of the test group 3 is lowest, and is significantly reduced by 2.78%, (P＜0.05）。
As can be seen from the table, compared with the control group, the addition of the iron source obviously improves the number of red blood cells, the hemoglobin content and the hematocrit of the weaned piglets, and the iron supplement composition has the best feeding effect, and the feeding effect of the ferrous glycine preparation is inferior to that of the inorganic iron preparation. Experiment 3 the number of red blood cells, hemoglobin content and hematocrit of the weaned piglets are respectively increased by 21.60 percent (compared with the control group)P＜0.01）、32.91%（P< 0.01) and 13.33%, (P< 0.01); 1.57% higher than that of the test 2 group (P＜0.05）、9.09%（P> 0.05) and 2.26% ((II)PGreater than 0.05), the iron supplement composition of the invention has a tendency to increase hemoglobin content and hematocrit compared to ferrous glycinate preparations.
Compared with a control group, the iron supplement composition added into the daily ration of the weaned pig can obviously reduce the total iron binding force of serum, but the difference among the three test groups is not obvious; the iron supplement composition added into the daily ration can obviously improve the ferritin in the bodies of the piglets by 9.83% (for example, the total iron supplement composition is added into the daily ration)P＜0.05）、19.29%（P< 0.01) and 15.63%, (P< 0.01); the ferrous glycinate preparation and the iron supplement composition can obviously reduce the transferrin content in the weaned pigs by 12.15 percent (respectively)P< 0.05) and 15.44%, (P＜0.05）。
TIBC, Fn and Tf are often important indicators for assessing iron nutrition status. When an animal develops iron deficiency anemia, iron in the animal serves to maintain physical needs, which in turn causes a decrease in Fn levels and an increase in TIBC and Tf levels. In the research, the piglet diet is added with an iron source, so that the Fn content of a piglet organism is obviously improved, the TIBC and Tf content is reduced, the piglet diet added with the iron source has a certain effect of improving the serum iron nutrition of piglets, and compared with an inorganic iron preparation and a ferrous glycinate preparation, the iron supplement composition has a better effect.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the technical principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (8)
1. A composition for supplementing iron comprises active ingredients including sodium iron chlorophyllin, faeces Bombycis, Scutellariae radix, radix Angelicae sinensis, herba et Gemma Agrimoniae, radix Paeoniae alba, radix Codonopsis, Eucommiae cortex, Glycyrrhrizae radix, and vitamin B2Vitamin B6Vitamin B12Vitamin A, vitamin C, polyoxin and the like.
2. The iron supplement composition according to claim 1, wherein the active ingredients comprise 60-140 parts of sodium iron chlorophyllin, 30-70 parts of silkworm excrement, 5-15 parts of scutellaria baicalensis, 10-20 parts of angelica sinensis, 10-20 parts of agrimony, 10-20 parts of radix paeoniae alba, 10-50 parts of codonopsis pilosula, 10-20 parts of eucommia ulmoides, and,3-10 parts of liquorice and vitamin B22-8 parts of vitamin B61-5 parts of vitamin B120.01-0.3 part, 1-10 parts of vitamin A, 30-80 parts of vitamin C and 1-20 parts of polyoxin.
3. The iron supplement composition according to claim 2, wherein the active ingredients comprise 80-120 parts of sodium iron chlorophyllin, 40-60 parts of silkworm excrement, 7-12 parts of scutellaria baicalensis, 12-17 parts of angelica sinensis, 12-17 parts of agrimony, 12-17 parts of radix paeoniae alba, 20-40 parts of codonopsis pilosula, 12-17 parts of eucommia ulmoides, 4-7 parts of liquorice and vitamin B23-6 parts of vitamin B62-4 parts of vitamin B120.1-0.25 part, 4-7 parts of vitamin A, 40-60 parts of vitamin C and 5-15 parts of polyoxin.
4. The iron supplement composition according to claim 3, wherein the active ingredients comprise 100 parts of sodium iron chlorophyllin, 50 parts of silkworm excrement, 10 parts of scutellaria baicalensis, 15 parts of angelica sinensis, 15 parts of agrimony, 15 parts of radix paeoniae alba, 30 parts of codonopsis pilosula, 15 parts of eucommia ulmoides, 6 parts of liquorice and vitamin B25 portions of vitamin B63 portions of vitamin B120.2 part, 6 parts of vitamin A, 50 parts of vitamin C and 10 parts of polyoxin.
5. A method for preparing the iron supplement composition according to any one of claims 1 to 4, comprising the steps of:
(1) weighing sodium iron chlorophyllin and vitamin B according to weight ratio2Vitamin B6Vitamin B12Vitamin A, vitamin C and polyoxin are taken as a component 1;
(2) weighing faeces Bombycis, Scutellariae radix, radix Angelicae sinensis, herba et Gemma Agrimoniae, radix Paeoniae alba, radix Codonopsis, Eucommiae cortex, and Glycyrrhrizae radix as component 2;
(3) pulverizing the weighed component 2, sieving, or extracting the weighed component 2 with water or alcohol, concentrating, adding the component 1, mixing, and adding pharmaceutically acceptable adjuvants or auxiliary components.
6. The method for preparing an iron supplement composition according to claim 5, wherein the prepared formulation is: premix, powder, tablet, granule, and oral liquid.
7. The use of the iron-supplementing composition according to any one of claims 1 to 4 for preparing a medicament for preventing and treating iron-deficiency anemia in livestock and poultry.
8. The use of the iron-supplementing composition according to any one of claims 1 to 4 for preparing a feed for preventing and treating iron deficiency anemia in livestock and poultry.
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