CN103536638B - It is a kind of to treat medicine of gastrointestinal dysfunction and preparation method thereof - Google Patents
It is a kind of to treat medicine of gastrointestinal dysfunction and preparation method thereof Download PDFInfo
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Abstract
The disorderly pharmaceutical composition of digestive system function is treated the invention provides a kind of, it is characterised in that including following component：10~25 parts of ginseng, 10~25 parts of the bighead atractylodes rhizome, 12~25 parts of Poria cocos, in terms of parts by weight.Present invention is particularly suitable for gastrointestinal dysfunction after treatment radiotherapy or chemotherapy, good effect has no toxic side effect, and patient tolerability is good, be easy to receiving, and treatment cost is low.Gastrointestinal dysfunction after treatment radiotherapy or chemotherapy can be individually used for, chemicotherapy can be also combined and be treated malignancy disease.
Description
Technical field
It is specifically a kind of to treat gastrointestinal dysfunction caused by radiotherapy or chemotherapy the present invention relates to a kind of Chinese medicine composition
Medicine and preparation method thereof, the gastrointestinal dysfunction that more particularly, to treatment radiotherapy, chemotherapy cause.
Background technology
Gastrointestinal dysfunction after chemicotherapy（Gastrointestinal Dysfunction）It is malignant tumor patient radiotherapy
One of with complication common after chemotherapy.Clinical manifestation for poor appetite, apocleisis, nausea, vomiting, diarrhoea even spitting blood, have blood in stool
Deng mainly relevant to the coup injury of gastrointestinal tract epithelial cell with radiotherapy and chemotherapy medicine.Due to malignant tumor patient Abwehrkraft des Koepers
With GI epithelium tissue self-regeneration function reduction, the not normal symptom of the gastrointestinal function sustainable long period, unfavorable after chemicotherapy
The rehabilitation of patient and further treatment.
The content of the invention
The disorderly pharmaceutical composition of digestive system function is treated it is an object of the invention to provide a kind of.
The purpose of the present invention is realized by following measures：
A kind of pharmaceutical composition for treating gastrointestinal dysfunction, it is characterised in that including following component：10~25 parts of ginseng,
10~25 parts of the bighead atractylodes rhizome, 12~25 parts of Poria cocos, in terms of parts by weight.
The effect of for the strengthening the spleen and replenishing qi for strengthening pharmaceutical composition, and benefiting qi and nourishing yin, aforementioned pharmaceutical compositions also include Huang
15~50 parts of stilbene, 15~30 parts of Chinese yam.
In order to adjust function transporting, dispersing stagnated hepatoqi promotes the transporting of pharmaceutical composition to absorb, aforementioned pharmaceutical compositions
Also include 12~20 parts of radix bupleuri, 12~30 parts of the dried immature fruit of citron orange, 15~3 parts of RADIX PAEONIAE ALBA.
In order to light chronic inflammation, and removing damp-heat is mitigated or eliminated, aforementioned pharmaceutical compositions further comprises the coptis 10~12
Part, 10~15 parts of the root of large-flowered skullcap.
In order to nurse one's health lung qi, promoting the circulation of qi eliminating phlegm, aforementioned pharmaceutical compositions also include 12~15 parts of orange peel, 10~15 parts of the tuber of pinellia.
In order in and/or eliminating as much as the side effect that the medicine is produced, aforementioned pharmaceutical compositions also include windproof 10~
15 parts, 10~15 parts of wrinkled giant hyssop, 12~30 parts of hawthorn, 10~15 parts of Amomum cardamomum, 5~10 parts of Radix Glycyrrhizae.
Number of the present invention is with weight ratio meter.
Pharmaceutical composition of the invention can be made the various formulations allowed in pharmacy, to be made different types, can
The auxiliary material for medically allowing is introduced in Chinese medicine of the invention, such as：Disintegrant, lubricant, adhesive, flavouring, effervescent agent is helped
Suspension, dispersant, surfactant, stabilizer, colouring agent etc..
Pharmaceutical composition of the invention is preferably and is decocted in water for oral dose, and in order to gastrointestinal absorption, easy damaged stomach and intestine, are not required to other works
Sequence, letter is just, honest and clean, effect.
Or, the preparation method of pharmaceutical composition of the present invention is comprised the following steps：
（1）Each drug component is weighed according to formula, is mixed, crushed；
（2）Under normal temperature in 60% ethanol, it is degree that ethanol solution flooded 5 centimeters of medicine, after impregnating 3 days, taking liquid；
（3）The dregs of a decoction again with 60% alcohol dipping twice, respectively impregnate 2 days and 1 day, taking liquid；
（4）Merge three liquids, after reclaiming ethanol, obtain medicinal extract, the dry for standby at 70 DEG C；
（5）Take dry extract crushing, filling into capsule or honeyed bolus, cured ball, per 25 grams of parts of ball；
（6）Each serving 3, take daily 3 times, point early, middle and late, one hour before meals clothes.
Beneficial effect
1. the present invention can effectively treat gastrointestinal dysfunction, particularly radiotherapy, chemotherapy, and caused poor appetite, apocleisis is disliked
The heart, vomiting, diarrhoea even spitting blood, the clinical symptoms such as have blood in stool, QI invigorating and in, soothing liver-qi stagnation, the square medicine of regulating spleen and stomach, so that putting
Treat patients undergoing chemotherapy and recover stomach and intestine normal physiological function as early as possible, be conducive to Rehabilitation and follow-up further treatment, even and reduce
Eliminate the side effect that medicine brings.
Wherein, ginseng, the bighead atractylodes rhizome, Poria cocos, honey-fried licorice root, replenish qi to invigorate the spleen, and are monarch drug in a prescription.The Radix Astragali, Chinese yam, radix bupleuri, RADIX PAEONIAE ALBA, product
It is real, it is altogether ministerial drug.Radix Astragali tonifying middle-Jiao and Qi, is risen and lifts yang-energy, helps its strong fortune, Chinese yam supplementing qi and nourishing yin, invigorating the spleen to arrest diarrhea, and tonifying lung, kidney tonifying are helped
Ginseng, bighead atractylodes rhizome skin are just；Radix bupleuri, RADIX PAEONIAE ALBA, product is real, soothing liver-qi stagnation, regulating spleen and stomach, helps its strong fortune and freely mechanism of qi.Assistant：The coptis, it is yellow
A kind of reed mentioned in ancient books, it is clearing heat and detoxicating, transport spleen and removing dampness；It is eliminating dampness and eliminating phlegm during orange peel qi-regulating is adjusted, help spleen health movement；Tuber of pinellia stopping nausea and vomiting by lowering the adverse flow of QI, opens knot except ruffian, helps
Stomach and drop；It is windproof, dissipate liver and dredge spleen, and imperial ailment said due to cold or exposure；Wrinkled giant hyssop, eliminates dampness with aromatics, the dim stomach of promoting the circulation of qi, and inducing diaphoresis is with；Hawthorn, promoting digestion and removing indigestion,
Taste are helped to eliminate knot gas；Amomum cardamomum, dampness elimination promoting the circulation of qi, warming middle energizer to arrest vomiting.Honey-fried licorice root not only can also reconcile each medicine with QI invigorating, also may be used
To make medicine.Make a general survey of full side, tonification and purgation in combination, fever and chills are shared, with not beneficial disease is mended, attack and do not hinder just, with replenishing qi to invigorate the spleen, it is soothing the liver and
The effects such as stomach, ascending the clear and descending the turbid.
2. the digestive system function according to motherland's theory of medicine for radiotherapy, chemotherapy and caused by Other diseases is disorderly
Random patient carries out traditional Chinese medical herbal treatment, is the characteristic and advantage of China.Patient and Other diseases patient after radiotherapy, chemotherapy,
Because of the influence of disease itself and side effects of pharmaceutical drugs and mental element, the damage of viscera is caused first, resistance against diseases subtracts
It is weak, easily for exopathogen is taken advantage of a weak point.Digestive system function is disorderly to decline with the positive deficiency of vital energy, simulataneous insufficiency and excessive, cold-heat jumble, perverse trend invasion and attack,
Feeding desorder and mental element etc. are relevant.To this kind of patient, if only righting, healthy tendency is difficult multiple, and perverse trend difficulty is removed, if only eliminating evil or
Promote digestion merely, not only disease can not be removed, healthy tendency is damaged on the contrary and easily causes a disease heresy deeply, aggravate the state of an illness, and digestive system function is disorderly
Disorderly it is more difficult to recover.
In traditional Chinese medicine, gastrointestinal dysfunction and spleen, stomach, liver, large intestine relation it is the closest, because stomach and the spleen channel pulse-phase connect,
Mutually constitute relation in the dirty table with internal organs；Between taste, negative and positive are harmonious, mutual causality of ascending and descending, interdependence between drying and moistening, can just maintain human diet
The normal function digested and assimilated of thing.It is also phase on pathology and spleen, stomach, liver, intestines, courage etc. are being also physiologically interdependence
Mutually influence.The present invention replenishes qi to invigorate the spleen, soothing liver and harmonizing stomach, ascending the clear and descending the turbid, strengthening vital QI to eliminate pathogenic factors, also well treatment chemicotherapy after after disappear
Change system dysfunction.
3., present invention is particularly suitable for gastrointestinal dysfunction after treatment radiotherapy or chemotherapy, good effect has no toxic side effect, and suffers from
Person's better tolerance, it is easy to receive, treatment cost is low.Gastrointestinal dysfunction after treatment radiotherapy or chemotherapy can be individually used for, can also be tied
Close chemicotherapy treatment malignancy disease.
Brief description of the drawings
Fig. 1 is the gastroscope figure before embodiment 1 is treated.
Fig. 2 is the gastroscope figure after embodiment 1 is treated.
Fig. 3 is the gastroscope figure before embodiment 2 is treated.
Fig. 4 is the gastroscope figure after embodiment 2 is treated.
Fig. 5 is the gastroscope figure before embodiment 3 is treated.
Fig. 6 is the gastroscope figure after embodiment 3 is treated.
Fig. 7 is the gastroscope figure before embodiment 4 is treated.
Fig. 8 is the gastroscope figure after embodiment 4 is treated.
Fig. 9 is the gastroscope figure before embodiment 5 is treated.
Figure 10 is the gastroscope figure after embodiment 5 is treated.
Specific embodiment
With reference to embodiment, the present invention is expanded on further.But the present invention is not limited to embodiment.
Embodiment 1
Weigh 25 grams of ginseng, 25 grams of the bighead atractylodes rhizome, 25 grams of Poria cocos, 30 grams of the Radix Astragali, 30 grams of Chinese yam, 20 grams of radix bupleuri, 30 grams of the dried immature fruit of citron orange,
30 grams of RADIX PAEONIAE ALBA, 12 grams of the coptis, 15 grams of the root of large-flowered skullcap, 15 grams of orange peel, 15 grams of the tuber of pinellia, windproof 15 grams, 15 grams of wrinkled giant hyssop, 30 grams of hawthorn, in vain
15 grams of cardamom, 10 grams of Radix Glycyrrhizae.
First by all herbal medicine immersions 15 minutes, then add water and flooded medicine one-inch or so, decocted 25~30 minutes with moderate heat, altogether
Decoct 2 times, 400~500 milliliters of taking liquid, divide 3 times orally, each serving 150 milliliters or so, one one.
Typical cases：
Patient Lee so-and-so, man, 65 years old, certain Automobile Transportation Company driver.
First visit：In August, 2004 does radiotherapy, postoperative appearance poor appetite, apocleisis, nausea, vomiting, diarrhoea, the side of body because suffering from liver cancer
Bitterly, body is become thin, sallow complexion, the tongue is coated, red tongue body, the disease such as wiry and frequent pulse.
Tcm diagnosis are insufficiency of the spleen liver depression, retention of damp-heat in the interior, disturbance in ascending and descending.Take prescription described in embodiment 1.
Two examine：Behind patient's clothes top, nausea is felt, vomiting, diarrhoea has taken a turn for the better, but still sense poor appetite, apocleisis, the side of body
Bitterly, tongue fur, tongue nature and pulse condition change are little.Medicine has won initial success, no more side effects, then takes 2 doses.
Three examine：2 doses are after administration, not nauseous, vomiting, apocleisis, and appetite enhancing, hypochondriac pain mitigates, malignant diseases, it is difficult to which speed heals,
Successively altogether 25 doses above clothes, poor appetite, apocleisis, nausea, vomiting, diarrhoea, hypochondriac pain, body is become thin, the tongue is coated, red tongue body,
The diseases such as wiry and frequent pulse, by turning light again, are gradually taken a turn for the better, and body is not become thin, finally recover normal.Now suffer from flying and survive more than 6 years, state of an illness ratio
Relatively stablize.Repeatedly check that liver cancer is still present, and has reduced than the initial stage.
Fig. 1 is the gastroscope figure before treatment；Fig. 2 is the gastroscope figure after treatment.
Embodiment 2
Weigh 12 grams of ginseng, 12 grams of the bighead atractylodes rhizome, 15 grams of Poria cocos, 20 grams of the Radix Astragali, 20 grams of Chinese yam, 15 grams of radix bupleuri, the dried immature fruit of citron orange 15
Gram, 20 grams of RADIX PAEONIAE ALBA, 10 grams of the coptis, 12 grams of the root of large-flowered skullcap, 15 grams of orange peel, 12 grams of the tuber of pinellia, windproof 12 grams, 12 grams of wrinkled giant hyssop, hawthorn 15
Gram, 12 grams of Amomum cardamomum, 10 grams of Radix Glycyrrhizae.
First by all herbal medicine immersions 15 minutes, then add water and flooded medicine one-inch or so, decocted 25~30 minutes with moderate heat, altogether
Decoct 2 times, 400~500 milliliters of taking liquid, divide 3 times orally, each serving 150 milliliters or so, one one.Had blood in stool during because of stool,
Add every time 0.5 gram of ' Yunnan Baiyao ', strengthen anastalsis.
Typical cases：
Patient, it is remaining so-and-so, man, 72 years old, government functionary.
First visit：Patient, is non-proliferation in October, 2008 because of intestinal cancer row resection, postoperative to do chemotherapy again,
Afterwards occur poor appetite, apocleisis, nausea, vomiting, diarrhoea, hypochondriac pain, when have blood in stool, body is become thin, sallow complexion, tongue
Tongue thickness is greasy, red tongue body, the disease such as wiry and frequent pulse.
Tcm diagnosis are：Insufficiency of the spleen liver depression, retention of damp-heat in the interior, disturbance in ascending and descending.Take prescription described in embodiment 2.
Two examine：Behind patient's clothes top, nausea is felt, vomiting, diarrhoea has been taken a turn for the better, and number of times of having blood in stool is reduced, but still sense appetite
Depressed, apocleisis, hypochondriac pain, tongue fur, tongue nature and pulse condition change are little.Medicine has won initial success, no more side effects, then takes 2 doses.
Three examine：2 doses after administration, not nauseous, vomiting, apocleisis, and appetite enhancing, hypochondriac pain mitigates, without having blood in stool.Malignant diseases,
It is difficult to speed to heal, successively clothes more than 30 agent of top altogether, poor appetite, apocleisis, nausea, vomiting, diarrhoea, hypochondriac pain, body is become thin, thick libngual fur
Greasy, red tongue body, the disease such as wiry and frequent pulse, by turning light again, is gradually taken a turn for the better, and body is not become thin, finally recovers normal.Sui is visited 3 years, is not sent out
Existing ANOMALOUS VARIATIONS.
Fig. 3 is the gastroscope figure before treatment；Fig. 4 is the gastroscope figure after treatment.
Embodiment 3
It is medicinal：12 grams of ginseng, 12 grams of the bighead atractylodes rhizome, 15 grams of Poria cocos, 20 grams of the Radix Astragali, 20 grams of Chinese yam, 15 grams of radix bupleuri, the dried immature fruit of citron orange 15
Gram, 20 grams of RADIX PAEONIAE ALBA, 10 grams of the coptis, 12 grams of the root of large-flowered skullcap, 15 grams of orange peel, 12 grams of the tuber of pinellia, windproof 12 grams, 12 grams of wrinkled giant hyssop, hawthorn 15
Gram, 12 grams of Amomum cardamomum, 10 grams of Radix Glycyrrhizae.
First by all herbal medicine immersions 15 minutes, then add water and flooded medicine one-inch or so, decocted 25~30 minutes with moderate heat, altogether
Decoct 2 times, 400~500 milliliters of taking liquid, divide 3 times orally, each serving 150 milliliters or so, one one.
Typical cases
First visit：Patient's model so-and-so, female, 35 years old, doctor, in April, 2008 because of breast cancer, row resection is to prevent its expansion
Dissipate, it is postoperative to do chemotherapy again, occur poor appetite afterwards, apocleisis, nausea, vomiting, diarrhoea, pectoralgia, hypochondriac pain, body is become thin, and complexion is withered
The diseases such as Huang, the tongue is coated, red tongue body, wiry and frequent pulse.
Tcm diagnosis are：Insufficiency of the spleen liver depression, retention of damp-heat in the interior, disturbance in ascending and descending.Take prescription described in embodiment 3.
Two examine：Behind patient's clothes top, nausea is felt, vomiting, diarrhoea has been taken a turn for the better, and number of times of having blood in stool is reduced, but still sense appetite
Depressed, apocleisis, hypochondriac pain, pectoralgia, tongue fur, tongue nature and pulse condition change are little.Medicine has won initial success, no more side effects, then takes 2 doses.
Three examine：2 doses are after administration, not nauseous, vomiting, apocleisis, and appetite enhancing, hypochondriac pain, pectoralgia mitigates, malignant diseases, it is difficult to
Speed heals, successively clothes more than 20 agent of top altogether, and poor appetite, apocleisis, nausea, vomiting, diarrhoea, hypochondriac pain, body is become thin, the tongue is coated,
The diseases such as red tongue body, wiry and frequent pulse, by turning light again, are gradually taken a turn for the better, and body is not become thin, finally recover normal.Sui is visited 3 years, Huan Zhewei
Go out the disorderly grade disease of gastrointestinal function again.
Fig. 5 is the gastroscope figure before treatment；Fig. 6 is the gastroscope figure after treatment.
Embodiment 4
Weigh 10 grams of ginseng, 10 grams of the bighead atractylodes rhizome, 12 grams of Poria cocos, 15 grams of the Radix Astragali, 15 grams of Chinese yam,
12 grams of radix bupleuri, 12 grams of the dried immature fruit of citron orange, 15 grams of RADIX PAEONIAE ALBA, 10 grams of the coptis, 10 grams of the root of large-flowered skullcap, 12 grams of orange peel, 10 grams of the tuber of pinellia,
Windproof 10 grams, 10 grams of wrinkled giant hyssop, 12 grams of hawthorn, 10 grams of Amomum cardamomum, 5 grams of Radix Glycyrrhizae.
First by all herbal medicine immersions 15 minutes, then add water and flooded that medicine is not far to cross one-inch, decocted 25~30 minutes with moderate heat,
Decoct 2 times altogether, 200~300 milliliters of taking liquid, divide 3 times orally, each serving 80~100 milliliters or so, one one.
Typical cases
First visit：, in June, 2007 because leukaemia does chemotherapy, there is poor appetite in patient woods, man, pupil after chemotherapy, detest
Food, nausea, vomiting, diarrhoea, overall pain, body is become thin, lassitude, sallow complexion, the tongue is coated, red tongue body, wiry and frequent pulse
Deng disease.
Tcm diagnosis are：Insufficiency of the spleen liver depression, retention of damp-heat in the interior, disturbance in ascending and descending.Take prescription described in embodiment 4.
Two examine：Behind patient's clothes top, nausea is felt, vomiting, diarrhoea has taken a turn for the better, but still sense poor appetite, apocleisis, entirely
Body pain, lassitude, body is become thin, tongue fur, and tongue nature and pulse condition change are little.Medicine has won initial success, no more side effects, then takes 2
Agent.
Three examine：2 doses are after administration, not nauseous, vomiting, apocleisis, and appetite enhancing, overall pain, lassitude has taken a turn for the better,
Malignant diseases, it is difficult to which speed heals, successively clothes more than 20 agent of top altogether, poor appetite, apocleisis, nausea, vomiting, body is become thin, overall pain,
The diseases such as lassitude, the tongue is coated, red tongue body, wiry and frequent pulse, by turning light again, are gradually taken a turn for the better, and body is not become thin, are finally recovered just
Often.Sui is visited 2 years, this prescription is taken after Chemotherapy in Patients and does not go out the disorderly grade disease of gastrointestinal function again.
Fig. 7 is the gastroscope figure before treatment；Fig. 8 is the gastroscope figure after treatment.
Embodiment 5
Weigh 25 grams of ginseng, 25 grams of the bighead atractylodes rhizome, 25 grams of Poria cocos, 30 grams of the Radix Astragali, 30 grams of Chinese yam, 20 grams of radix bupleuri, 30 grams of the dried immature fruit of citron orange,
30 grams of RADIX PAEONIAE ALBA, 12 grams of the coptis, 15 grams of the root of large-flowered skullcap, 15 grams of orange peel, 15 grams of the tuber of pinellia, windproof 15 grams, 15 grams of wrinkled giant hyssop, 30 grams of hawthorn, in vain
15 grams of cardamom, 10 grams of Radix Glycyrrhizae.
First by all herbal medicine immersions 15 minutes, then add water and flooded medicine one-inch or so, decocted 25~30 minutes with moderate heat, altogether
Decoct 2 times, 500~600 milliliters of taking liquid, divide 3 times orally, each serving 150~180 milliliters or so, one one.
Typical cases
Patient, Lee so-and-so, female, in October, 2009 because lymthoma does chemotherapy, postoperative appearance poor appetite, apocleisis, nausea,
Vomiting, diarrhoea, overall pain, body is become thin, lassitude, sallow complexion, paramenia, few through amount, the tongue is coated, tongue nature
It is red, the disease such as wiry and frequent pulse.
Tcm diagnosis are：Insufficiency of the spleen liver depression, retention of damp-heat in the interior, disturbance in ascending and descending.Take prescription described in embodiment 5.
Two examine：Behind patient's clothes top, nausea is felt, vomiting, diarrhoea has taken a turn for the better, but still sense poor appetite, apocleisis, entirely
Body pain, lassitude, body is become thin, tongue fur, and tongue nature and pulse condition change are little.Medicine has won initial success, no more side effects, then takes 2
Agent.
Three examine：2 doses are after administration, not nauseous, vomiting, apocleisis, and appetite enhancing, overall pain, lassitude has taken a turn for the better,
Malignant diseases, it is difficult to which speed heals, successively clothes more than 30 agent of top altogether, poor appetite, apocleisis, nausea, vomiting, body is become thin, overall pain,
The diseases such as lassitude, the tongue is coated, red tongue body, wiry and frequent pulse, by turning light again, are gradually taken a turn for the better, and body is not become thin, and rear menstruation is basic
Normally, increase earlier above through amount, finally recover normal.Sui is visited 2 years, and this prescription is taken after Chemotherapy in Patients, and not go out gastrointestinal function again disorderly etc.
Disease.
Fig. 9 is the gastroscope figure before treatment；Figure 10 is the gastroscope figure after treatment.
Claims (1)
1. a kind of pharmaceutical composition for treating gastrointestinal dysfunction after chemicotherapy, it is characterised in that：It is made up of following bulk drug：People
10~25 parts of ginseng, 10~25 parts of the bighead atractylodes rhizome, 12~25 parts of Poria cocos, 15~50 parts of the Radix Astragali, 15~30 parts of Chinese yam, 12~20 parts of radix bupleuri,
12~30 parts of the dried immature fruit of citron orange, 15~30 parts of RADIX PAEONIAE ALBA, 10~12 parts of the coptis, 10~15 parts of the root of large-flowered skullcap, 12~15 parts of orange peel, the tuber of pinellia 10~15
Part, windproof 10~15 parts, 10~15 parts of wrinkled giant hyssop, 12~30 parts of hawthorn, 10~15 parts of Amomum cardamomum, 5~10 parts of Radix Glycyrrhizae, with weight portion
Number meter.
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| CN102940846A (en) * | 2012-12-08 | 2013-02-27 | 南京正宽医药科技有限公司 | Traditional Chinese medicine composition for treating atrophic gastritis as welln as preparation method and application of composition |
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| CN103536638A (en) | 2014-01-29 |
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