CN113599483A - Composition for treating acid regurgitation and heartburn and preparation method thereof - Google Patents

Composition for treating acid regurgitation and heartburn and preparation method thereof Download PDF

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CN113599483A
CN113599483A CN202110712172.1A CN202110712172A CN113599483A CN 113599483 A CN113599483 A CN 113599483A CN 202110712172 A CN202110712172 A CN 202110712172A CN 113599483 A CN113599483 A CN 113599483A
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composition
heartburn
drugs
drug
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解军雷
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/754—Evodia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
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    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention discloses a composition for treating acid regurgitation and heartburn and a preparation method thereof, and relates to the field of traditional Chinese medicine compositions. The invention consists of monarch drugs, ministerial drugs and adjuvant drugs, wherein the monarch drugs are ginseng, bighead atractylodes rhizome and Chinese yam, the ministerial drugs are coptis, scutellaria and peony, and the adjuvant drugs are smoked plum, evodia, poria cocos and dried ginger; the traditional Chinese medicine composition is used for solving the problem of slow drug effect when the existing medicine composition is used for treating the symptoms of acid regurgitation and heartburn.

Description

Composition for treating acid regurgitation and heartburn and preparation method thereof
Technical Field
The invention relates to the field of traditional Chinese medicine compositions, in particular to a composition for treating acid regurgitation and heartburn.
Background
The gastric acid refers to gastric hypersecretion, stomach discomfort, acid regurgitation and stomach heartburn, and the gastric acid is caused by fire depression of liver channel, stagnated heat of liver and stomach and upward adverse flow of stomach qi, and then the spleen qi is weak, so that the gastrointestinal hypomotility, abdominal distension, inappetence, acid regurgitation, heartburn and other symptoms are caused; at present, most symptoms of acid regurgitation and heartburn are treated by western medicines which are characterized by rapid drug effect, but most western medicines are used for treating symptoms and root causes, and have no conditioning effect on human bodies. Compared with western medicines, the medicine for treating the chronic rhinitis can regulate the functions of the human body in the treatment process, but the existing important problems are slow in effect taking and long in treatment period.
Disclosure of Invention
The invention aims to provide a composition for treating sour regurgitation and heartburn and a preparation method thereof, and aims to solve the problem of slow drug effect in the treatment of the symptoms of sour regurgitation and heartburn.
In order to solve the problems, the invention adopts the following technical means:
a composition for treating acid regurgitation and heartburn comprises monarch drug, ministerial drug and adjuvant drug, wherein the monarch drug is Ginseng radix, Atractylodis rhizoma and rhizoma Dioscoreae, the ministerial drug is Coptidis rhizoma, Scutellariae radix and radix Paeoniae, and the adjuvant drug is mume fructus, fructus evodiae, Poria and Zingiberis rhizoma.
Further, the weight parts of the monarch drug are 45-75 parts, the ministerial drug is 25-55 parts, and the adjuvant drug is 14-39 parts.
Furthermore, by weight, 5-15 parts of ginseng, 20-30 parts of bighead atractylodes rhizome and 20-30 parts of Chinese yam; 10-20 parts of coptis chinensis, 10-20 parts of scutellaria baicalensis and 5-15 parts of peony; 3-8 parts of dark plum fruit, 3-8 parts of Wuyu, 5-15 parts of tuckahoe and 3-8 parts of dried ginger.
Furthermore, by weight, 10 parts of the ginseng, 25 parts of the bighead atractylodes rhizome and 25 parts of the Chinese yam; 15 parts of coptis chinensis, 15 parts of scutellaria baicalensis, 10 parts of peony, 5 parts of dark plum, 5 parts of fructus evodiae, 10 parts of poria cocos and 5 parts of dried ginger.
Also, a method for preparing a composition for treating acid regurgitation and heartburn according to the composition of any one of claims 1 to 4 in combination: the preparation steps consist of the following steps:
soaking the medicinal materials for 30-60 min, wherein the monarch drug is firstly added, the adjuvant drug is added after soaking for 5min, and the ministerial drug is added after soaking for 5 min;
after soaking, boiling with strong fire, then turning to small fire, keeping boiling state for 25min, completing first decoction, and filtering out the decoction as first juice;
adding warm water into the residue, boiling with strong fire, turning to slow fire, keeping boiling state for 25min to complete the second decoction, and filtering to obtain second decoction;
and mixing the first juice and the second juice to obtain a finished product.
And the soaking process of the medicinal materials is adjusted according to the months, and the medicinal materials are soaked for 60min in spring and winter and soaked for 30min in summer and autumn.
Compared with the traditional Chinese medicine for treating the symptoms of acid regurgitation and heartburn, the traditional Chinese medicine has the following beneficial effects:
the invention uses the principle of consolidating as a monarch drug through the cooperation of monarch, minister, assistant and guide, and then simultaneously relieves heart fire, relieves lung fire and removes spleen fire on the basis of consolidating the principle; and finally, the dark plum, the Wuyu, the tuckahoe and the dried ginger are used as the guiding drugs, so that the root-strengthening is mainly used to ensure that the functional efficacy of the ministerial drugs is quickly released, and further the action speed of the efficacy of the whole compound is accelerated, thereby realizing that the traditional Chinese medicine composition has the efficacy reaction speed and the treatment accuracy rate equivalent to those of western medicines under the condition that the traditional Chinese medicines can be used for regulating the functions of human bodies.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the embodiments of the present invention will be described in detail and completely with reference to the accompanying drawings.
Thus, the following detailed description of embodiments of the invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
In addition, the embodiments of the present invention and the features of the embodiments may be combined with each other without conflict.
Example 1
A composition for treating acid regurgitation and heartburn comprises monarch drug, ministerial drug and adjuvant drug, wherein the monarch drug is Ginseng radix, Atractylodis rhizoma and rhizoma Dioscoreae, the ministerial drug is Coptidis rhizoma, Scutellariae radix and radix Paeoniae, and the adjuvant drug is mume fructus, fructus evodiae, Poria and Zingiberis rhizoma.
The weight parts of the monarch drug, the ministerial drug and the adjuvant drug are 45 parts, 25 parts and 14 parts.
Specifically, 5 parts of ginseng, 20 parts of bighead atractylodes rhizome and 20 parts of Chinese yam; 10 parts of coptis chinensis, 10 parts of scutellaria baicalensis and 5 parts of peony; 3 parts of dark plum fruit, 3 parts of fructus evodiae, 5 parts of poria cocos and 3 parts of dried ginger.
And, the preparation is carried out in the following manner,
after the medicines are matched, soaking the medicinal materials for 30-60 min, wherein monarch medicines are firstly added, and after soaking for 5min, adjuvant medicines are added, and after soaking for 5min, ministerial medicines are added;
after soaking, boiling with strong fire, then turning to small fire, keeping boiling state for 25min, completing first decoction, and filtering out the decoction as first juice;
adding warm water into the residue, boiling with strong fire, turning to slow fire, keeping boiling state for 25min to complete the second decoction, and filtering to obtain second decoction;
and mixing the first juice and the second juice to obtain a finished product.
Wherein the soaking process of the medicinal materials is adjusted according to the month, and the medicinal materials are soaked for 60min in spring and winter and 30min in summer and autumn.
Example 2
A composition for treating acid regurgitation and heartburn comprises monarch drug, ministerial drug and adjuvant drug, wherein the monarch drug is Ginseng radix, Atractylodis rhizoma and rhizoma Dioscoreae, the ministerial drug is Coptidis rhizoma, Scutellariae radix and radix Paeoniae, and the adjuvant drug is mume fructus, fructus evodiae, Poria and Zingiberis rhizoma.
The weight parts of the monarch drug, the ministerial drug and the adjuvant drug are 75 parts, 55 parts and 39 parts.
Specifically, 15 parts of ginseng, 30 parts of bighead atractylodes rhizome and 30 parts of Chinese yam; 20 parts of coptis chinensis, 20 parts of scutellaria baicalensis and 15 parts of peony; 8 parts of dark plum fruit, 8 parts of fructus evodiae, 15 parts of poria cocos and 8 parts of dried ginger.
And, the preparation is carried out in the following manner,
after the medicines are matched, soaking the medicinal materials for 30-60 min, wherein monarch medicines are firstly added, and after soaking for 5min, adjuvant medicines are added, and after soaking for 5min, ministerial medicines are added;
after soaking, boiling with strong fire, then turning to small fire, keeping boiling state for 25min, completing first decoction, and filtering out the decoction as first juice;
adding warm water into the residue, boiling with strong fire, turning to slow fire, keeping boiling state for 25min to complete the second decoction, and filtering to obtain second decoction;
and mixing the first juice and the second juice to obtain a finished product.
Wherein the soaking process of the medicinal materials is adjusted according to the month, and the medicinal materials are soaked for 60min in spring and winter and 30min in summer and autumn.
Example 3
A composition for treating acid regurgitation and heartburn comprises monarch drug, ministerial drug and adjuvant drug, wherein the monarch drug is Ginseng radix, Atractylodis rhizoma and rhizoma Dioscoreae, the ministerial drug is Coptidis rhizoma, Scutellariae radix and radix Paeoniae, and the adjuvant drug is mume fructus, fructus evodiae, Poria and Zingiberis rhizoma.
The weight parts of the monarch drug, the ministerial drug and the adjuvant drug are 60 parts, 40 parts and 25 parts.
Specifically, the ginseng is 10 parts, the bighead atractylodes rhizome is 25 parts, and the Chinese yam is 25 parts; 15 parts of coptis chinensis, 15 parts of scutellaria baicalensis, 10 parts of peony, 5 parts of dark plum, 5 parts of fructus evodiae, 10 parts of poria cocos and 5 parts of dried ginger.
And, the preparation is carried out in the following manner,
after the medicines are matched, soaking the medicinal materials for 30-60 min, wherein monarch medicines are firstly added, and after soaking for 5min, adjuvant medicines are added, and after soaking for 5min, ministerial medicines are added;
after soaking, boiling with strong fire, then turning to small fire, keeping boiling state for 25min, completing first decoction, and filtering out the decoction as first juice;
adding warm water into the residue, boiling with strong fire, turning to slow fire, keeping boiling state for 25min to complete the second decoction, and filtering to obtain second decoction;
and mixing the first juice and the second juice to obtain a finished product.
Wherein the soaking process of the medicinal materials is adjusted according to the month, and the medicinal materials are soaked for 60min in spring and winter and 30min in summer and autumn.
Comparative example 1
The decoction prepared in the embodiment 3 of the invention is used for diagnosis and treatment before patients A, men and 35 years old have a history of multiple chronic gastritis and are aggravated by heart burn. Stomach acid discomfort, heartburn, cold food and hot food aggravation, dysphoria with smothery sensation in the heart and chest, lassitude and hypodynamia, defecation for 2-3 days for 1 time without difficulty, red tongue with yellow and greasy coating, and weak pulse. The medicine is dispensed and the soup is prepared, 700 g of the soup is taken in seven days, when the patient feels hunger and can eat, the patient burns heart and stops, and then the treatment is fixed for one week.
Comparative example 2
Patient B, male, 32 years old, nausea, anorexia, dark urine color, no fever, cough, and normal defecation. The Lansoprazole orally disintegrating tablets are taken at an interval of 30mg/d for 1 day, the shape is obviously improved after 2 weeks, and the liver function is rechecked to be normal. No adverse reaction occurs.
In conclusion, the treatment period of the traditional Chinese medicine is similar to that of the western medicine, so that the traditional Chinese medicine has lower harm to human bodies compared with the western medicine, and the medicine effect of the western medicine is effectively combined with the recuperation characteristic of the traditional Chinese medicine
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes in the embodiments and/or modifications of the invention can be made, and equivalents and modifications of some features of the invention can be made without departing from the spirit and scope of the invention.

Claims (6)

1. A composition for treating acid regurgitation and heartburn, comprising: the traditional Chinese medicine composition is composed of monarch drugs, ministerial drugs and adjuvant drugs, wherein the monarch drugs are ginseng, bighead atractylodes rhizome and Chinese yam, the ministerial drugs are coptis chinensis, scutellaria baicalensis and peony, and the adjuvant drugs are smoked plum, Wuyu, poria cocos and dried ginger.
2. The composition for treating acid regurgitation and heartburn according to claim 1 wherein: the weight parts of the monarch drug, the ministerial drug and the adjuvant drug are 45-75 parts, 25-55 parts and 14-39 parts.
3. A composition for the treatment of acid regurgitation and heartburn according to claim 1 or 2 wherein: 5-15 parts of ginseng, 20-30 parts of bighead atractylodes rhizome and 20-30 parts of Chinese yam in parts by weight; 10-20 parts of coptis chinensis, 10-20 parts of scutellaria baicalensis and 5-15 parts of peony; 3-8 parts of dark plum fruit, 3-8 parts of Wuyu, 5-15 parts of tuckahoe and 3-8 parts of dried ginger.
4. A composition for the treatment of acid regurgitation and heartburn according to claim 1 or 2 wherein: 10 parts of ginseng, 25 parts of bighead atractylodes rhizome and 25 parts of Chinese yam in parts by weight; 15 parts of coptis chinensis, 15 parts of scutellaria baicalensis, 10 parts of peony, 5 parts of dark plum, 5 parts of fructus evodiae, 10 parts of poria cocos and 5 parts of dried ginger.
5. A preparation method of a composition for treating acid regurgitation and heartburn is characterized by comprising the following steps: a composition according to any one of claims 1 to 4 in combination: the preparation steps consist of the following steps:
soaking the medicinal materials for 30-60 min, wherein the monarch drug is firstly added, the adjuvant drug is added after soaking for 5min, and the ministerial drug is added after soaking for 5 min;
after soaking, boiling with strong fire, then turning to small fire, keeping boiling state for 25min, completing first decoction, and filtering out the decoction as first juice;
adding warm water into the residue, boiling with strong fire, turning to slow fire, keeping boiling state for 25min to complete the second decoction, and filtering to obtain second decoction;
and mixing the first juice and the second juice to obtain a finished product.
6. The method for preparing a medicament for treating icterohepatitis according to claim 7, wherein the medicament comprises: the soaking process of the medicinal materials is adjusted according to the month, and the medicinal materials are soaked for 60min in spring and winter and 30min in summer and autumn.
CN202110712172.1A 2021-06-25 2021-06-25 Composition for treating acid regurgitation and heartburn and preparation method thereof Pending CN113599483A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103536638A (en) * 2013-10-22 2014-01-29 第三军医大学第二附属医院 Medicament for treating gastrointestinal dysfunction and preparation method thereof
CN106729568A (en) * 2017-01-17 2017-05-31 李赛美 A kind of drug regimen for treating ulcerative colitis
CN113288993A (en) * 2021-02-18 2021-08-24 北京本草方源药业集团有限公司 Compound low-temperature vacuum drying extraction powder and extraction method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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Application publication date: 20211105