JPH11158077A - Composition having alleviating effect on stress - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition consisting essentially of Hemerocallis disticha Donn var. kwanso Nakai, usable as medicines and healthy foods and useful for effects on an improvement of diseases in neural functions, sleep symptoms, etc., and alleviating effects on stress. SOLUTION: This composition is obtained by using Hemerocallis disticha Donn var. kwanso Nakai, preferably a flower bud of Hemerocallis fulva L., Zizyphi Spinosi Semen, Lilii Bulbus, Albizziae Flos and Nelumbinis Fructus as principal ingredients and further including one or more of Concha Margaritifera Usta, Zizyphi Inermi Fructus, Glycyrrhizae Radix, Acanthopanax Cortex, etc., a dried leaf of Eucommia ulmoides Oliver, Rhemanniae Rhizoma, Chrysanthemi Flos, Coicis Semen, a leaf of Ginkgo biloba L., Aurantii Nobilia Pericarpium, Ganoderma lucidum Karst. and Hordeum vulgare L. The composition preferably contains <=30% of the Hemerocallis disticha Donn var. kwanso Nakai, the flower bud of the Hemerocallis fulva L., Zizyphi Spinosi Semen and Nelumbinis Fructus, <=20% of the Lilii Bulbus, Albizziae Flos, Acanthopanax Cortex, etc., and Concha Margaritifera Usta and <=10% of the Hordeum vulgare L, Zizyphi Inermi Fructus and Glycyrrhizae Radix in the ingredients. Furthermore, 15±5% of the Hemerocallis disticha Donn var. kwanso Nakai, 10±5% of the flower bud of the Hemerocallis fulva L., Albizziae Flos, Concha Margaritifera Usta and Acanthopanax Cortex, etc., 18±5% of the Zizyphi Spinosi Semen, 7±5% of the Hordeum vulgare L., ZZizyphi Inermi Fructus and Glycyrrhizae Radix and 3±3% of the Lilii Bulbus and Nelumbinis Fructus are preferably contained. Furthermor, <=5±3% of melatonin is preerably added thereto.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition which can be used as a medicinal or health food and has an effect of reducing stress, and more particularly to a composition which has an effect of bringing healthy sleep.

[0002]

In Japan, the United States and other advanced nations, there is a high level of competition in various fields, and stress is accumulated in the workers who support it. However, modern medicine is unable to respond effectively to stress, which is another situation that causes various chronic diseases. For example, even when taking sleeping pills, it can be said that the main focus was merely on stimulating the sleep center and the whole body was not considered. The response of Kampo medicine to such stress has been seen in old books, and Chinese herbal medicines that promote the improvement of the whole body have been used. An object of the present invention is to provide a composition having a stress reducing effect.

[0003]

In order to achieve the above-mentioned object, the present invention is characterized in that the main ingredient is forget-me-not or herb. As described above, the present inventors have repeatedly conducted research to meet the needs of society, devised and conducted research on Kampo medicines that supplement Western medicine with Chinese medicine or Chinese traditional medicine. As a result, it has been found that the composition according to the invention helps to reduce stress and has the consequence of providing a healthy sleep. Clinical studies have been conducted on neurosis, nervous breakdown, menopause, senile depression, and other fatigue syndromes that are generally considered to be caused by medical stress, and the above composition is effective for these stress-related diseases. It was confirmed that. In addition to the above components, the effect is improved by further adding acid jujube, lily, lily flower and lotus heart. Further, one or more of mother of pearl, large jujube, licorice, five ginseng, eucalypt, ground yellow stalk, chrysanthemum, ox rice, ginkgo biloba, cinnamon, reishi, and barley can be added. In addition, the above ingredients are 30% or less of forgetfulness, kaya grass flower, acid jujube and lotus root, 20% or less of lily, happiflower, gokasan and pearl mother, respectively, and 10% of barley, large jujube and licorice each. It is desirable to make the following composition ratios, and furthermore, 15 ± 5% for forgetfulness, 10 ± 5% for each of Kaya flower, Ganhua flower, mother of pearl and Gokasan, 18 ± 5% for acid jujube,
It is preferable that the barley, the jujube, and the licorice have a mixing ratio of 7 ± 5%, respectively, and the lily and the lotus root have a mixing ratio of 3 ± 3%, respectively. It is also possible to add 5% or less of melatonin to the above components.
The above-mentioned component ratio is the weight ratio of each herb, excluding the mother of pearl and melatonin, and after extracting the extract to dry powder. The mother-of-pearl is directly obtained from the mother

[0004]

Embodiments of the present invention will be described below. Each component used in the composition of the present invention will be described. The compositions of the present invention require a forget-me-not or herb flower. <Melancholy> The melancholy is a lily plant, kanzo, whose leaves and stem extracts are extracted, dried and used as a powder. This melancholy has a sedative effect, and has effects such as relieving insomnia and asthenopia. <Kayasohana> A bud of a forget-me-not flower, also known as golden needle vegetables or yellow flower vegetables, and is used in cooking. Similarly, the extract is extracted, dried and used as a powder. In addition to the above, it is effective to add acid jujube, lily, bonsai and lotus. <Satsuma Jin> Satsuma Jin is a juvenile juvenile of the buckthorn family (Rhamnaceae) Zizyphus jujubaMILL. Var. Spinosa H
U (= Z.vulgaris LAMARK.var.supinosus BUNGE, Z. su
pinosus HU) is a dried seed that has a sedative effect. <Yuri> Lilium brownii FE of the lily family (Liliaceae)
BROWN var. Colchesteri WILS., Hakata lily L. browni
i FE BR., Itoha lily L. tenuifolium FISCH., Oni lily L. lancifolium THUNB., Hime lily L. concolor
Dried scales of Lilium spp. Bulbs such as SALISB.
Rarely Yamayuri L. auratum LINDL., Sasa lily L. japoni
Use bulbs such as cum THUNB., L. lancifolium THUNB. [Origin] China [Ingredients] Contains a large amount of starch, and also contains fat, protein, etc. Other unknown. [Pharmacological action] Unknown. [Spicy, medicinal] Sweet. flat. [Medicinal properties] Yuri enters the heart, lungs and spleen, and has the effect of lung cleansing and spleen feeding, as well as antitussive and depleting effects. It is effective for fever, cough, and vomiting. <Happiness flower> Happiness flower is leguminosae (Leguminosae)
The flower bud of Albizzia julibrissinDURAZZ.
Has a stomach effect. <Renshin> Lotus is a lotus N of Nymphaeaceae
The dried mature fruit of elumbo nucifera GAERTNER is referred to as "stone lotus" or "lotus fruit", and the seeds obtained by removing the grain are referred to as "lotus meat". It is mainly produced in China (Hunan, Hubei, Fujian, Taiwan, Jiangsu, Zhejiang, Jiangxi, etc.). The components of the skin are unknown. The composition of the seed is 16.6% protein, 2.0% fat, 62.0% carbohydrate, 0.089% Ca, 0.285 P
% And 0.0064% of Fe. In addition to large amounts of starch raf
Including finose. Also includes various alkaloids. In other words, methylcorypal is added to the lotus root (bud NELUMBINIS EMBRYO)
ine (I), lotusine chloride (II), demethylcocl
aurine (III), isoliensinine (IV), liensinin
e (V), neferine (VI), N-nornuciferine, O-norn
uciferine (VII), (+)-pronuciferine (VII
I) has been found. D-(-)-N
-norarmepavine (IX), liriodenine (X), N-norn
It contains uciferine, nuciferine, etc. [Pharmacological action] It has been reported that methylcorypalline has a coronary vasodilatory action and demethylcoclaurine has a uterine smooth muscle relaxing action. [Medicinal properties] Lotus meat feeds the stomach and cleanses the heart when raw, and when heated, thickens the intestines and solidifies the kidneys. In general, it has the effects of spleen, nourishing, excretion, and solidity.
Cures diarrhea and blood. Shirenko is pure and depressing, and is used exclusively for dysentery. Renko wick has the effect of clarifying and relieving fever, and has the effect of Anjin and thirst, and cures anxiety, thirst, bloody bleeding, and sperm.

It is desirable to further add one or more of the following components to the above. The content of each component is shown. <Pearl mother> Pearl mother is pearl calcium (beta calc)
It is. Calcium is not only very important as a main component of the skeleton and the teeth, but it has been revealed that when the calcium concentration in the blood decreases, the excitability of nerves further increases. Insomnia requires calcium intake.
As calcium, there are pearl calcium, eggshell calcium, oyster shell calcium, mallow calcium, whey calcium, etc., but calcium is said to have a problem in absorption anyway, but nacre has a characteristic of high absorption efficiency . <Natsuju> Daiju is a juvenile of the family Sea buckthorn (Rhamnaceae) Ziyphus jujuba MILL. Var. Inermis (BUNGE) REH
D. (= Z. Vulgaris LAMARK var. Inermis BUNGE) or its varieties are dried and tonic. <Licorice> Glycyrrhiza glabra L. var. Gland, a licorice, is a leguminous family (Leguminosae)
uligera REG. et HERD. (= G. glanduliferaWALDSTEIN et
KITAIBEL) and Uralkan elephant (Tohoku licorice) Glycyr
ex DC. root and stron of rhizauralensis FISH. ex DC. <Gokasan> Gokasan is a Ukogi of Araliaceae.
It is the root bark and stem bark of Acanthopanax plants. Currently in the Chinese market, there are Kita Gokahide (Kougokahide, Nagiyanagi), Minamigokah,
There are three main types of red hair, five skins, of which north five skin is most frequently used. There are many more types depending on other regions. Gokahi is a medicine that removes wind, strengthens muscles, and has an analgesic effect. It is used for air removal and dehumidification by compounding a common drug, and is used for hard bones and muscles by compounding with a tonic. Therefore, it is used for rheumatism-like wind and paralysis pain, leg and knee pain,
It is also applied to various diseases such as edema. <Tonaka leaf> Tonaka leaf is a dried bark of Eucommia ulmoides OLIV. Of Eucommiaceae, and shows a remarkable blood pressure drop. Ground yellow stalk: The ground yellow stalk is Rehmannia gluti of Scrophulariaceae.
nosa (GAERTN.) LIBOSCH.var.hueichingensis CHAO et
SCHIH (= R. GlutinosaLIB.forma hueichingensis HSI
AO) radish as it is (dry ground yellow) or steamed
(Ripe ground yellow) It is dried and is effective for cool blood and blood supplementation. <Chrysanthemum> Chrysanthemum has antipyretic, detoxifying, anti-inflammatory and blood pressure lowering effects. <Cold rice> Coal rice is the coix of Gramineae
lacryma-jobi L. var. ma-yuen STAFF (= C. ma-yuen R
OMAN) dried mature seeds without the seed coat. [Pharmacological action] The acetone-soluble oily portion of the adlay seeds showed a marked growth inhibitory action against Yoshida's sarcoma. The main component, coixenolide, has a prolonged survival effect on Ehrlich ascites cancer in mice. Palmitic acid, the main component of seed fat oil, causes respiratory excitement in frogs, rats, and rabbits in a small amount, paralyzes it in large amounts, has a marked dilating effect on pulmonary blood vessels, and respiratory paralysis of morphine and urethane Has an anti-challenge effect. It has both dilation and contraction effects on peripheral blood vessels, and has a blood pressure lowering effect. It generally has a stimulatory effect on the uterus and reverses its excitatory effects after adrenaline is applied. For the intestinal tract, it contracts at low concentrations and relaxes at high concentrations. <Ginkgo biloba> Ginkgo biloba, whose main component is a flavonoid, normalizes (protects) the duck capillaries, controls platelet coagulation, prevents the formation of thrombus that causes infarction by clogging blood vessels, It has the function of smoothing blood flow. <Chen skin> Chen skin is a citrus family (Rutaceae)
Ex TANAKA (Dark mandarin orange, Fukutachi) and Cobenimikan C. erythrosa TANAKA (Zhu Tachibana)
Mature or immature pericarp is dried. In addition, Japanese-produced C. unshiu MARC. (= C. A.
urantium L. subsp.nobilis MAKINO var.unshiu MAKI
NO) (Chen skin) and Koji C. leiocarpa HORT. Ex TANAKA
(= C. Nobilis LOUR.subsp.suntara ENGL.var.kooj
i TANAKA) (citrus, tachibana skin). <Lingzhi> Lingzhi is Polynaceae (Polyporaceae)
Ganoderma lucidum (LEYSS. Ex FR.) KARST. It is a dried substance of the fruiting body of KARST. <Barley> Barley is a major cereal that is widely cultivated worldwide, and is an important cereal. The germinated malt contains a large amount of diastatase, and the saccharification power of starch is strong. <Melatonin> Melatonin is known as a sedative hormone. It is present as a kind of protein in plants, and natural products can be extracted from seaweed, oyster, corn and the like.

[0006] Of the above ingredients, 30% or less of forgetfulness, kaya grass, acid jujube and lotus root, 20% or less of lily, bonsai, gokasan and nacre, and 10% of barley, jujube and licorice. % Is preferably contained.

Next, the results of clinical observation will be shown as examples. <Example> Chocolate blossom, Kaya grass flower, acid jujube, lily, yuhuana, lotus root, jujube, licorice, gosan and barley are chopped, blended in the following ratio, and the mother of pearl powder is added thereto. , And dried under vacuum to obtain an extract powder. This was mixed with starch as an excipient, and pressed into 200 mg tablets. The component ratio is as follows. 01, 15%, Kayaso, Ganhua, Pearl Mother, Gosan, 10%, Satsumitsu Jin 18%, Barley, Daijutsu, and Licorice 7
% Of the composition containing 3% of lily and lotus root.
From December 995 to July 1996, clinical observations were made on the clinical treatment effect and safety in cooperation with the Changchun Medical School Hospital Internal Medicine and the Jilin Provincial People's Hospital's Central Medicine. The results are shown below.

1. Clinical data A total of 130 cases were observed, of which 100 were in the treatment group and 30 were in the control group. Mainly select mental illness. For example, neurosis, autonomic imbalance, and the like. The condition is mainly moderate or higher. The cases of the treated group and the control group are similar in gender, age, course, and medical condition, have undergone statistical processing, and have no significant differences.

2. Case selection (1) Diagnosis standard: 1, Chugoku diagnosis standard: insomnia, dreaming often, palpitations, headache,
Those who show symptoms such as dizziness. 2. Chuei Bensho Standard: Dreamy, easy to wake up, palpitations, amnesia, limb malaise, mental fatigue, loss of appetite, poor complexion, dullness. The tongue is pale, the tongue is large, and the tongue coating is white.
The pulse is thin and helpless. 3. Western medical diagnostic standards: those that apply to the diagnostic standards for neuropathy, menopause, fatigue syndrome, senile depression, etc. in "Internal Medicine" (University of Higher Medical School Third Edition). (2) Selected cases and excluded cases 1. Selected cases There are typical cases of insomnia, which last for more than one month, and which meet the diagnostic standards of the Chinese physician, the Bensho standard of the Chinese physician, and the Western medical diagnostic standards. 2. Exclusion cases (1) Symptoms such as insomnia, palpitations, and headache are due to systemic diseases. For example, due to pain, fever, surgery and the effects of the surrounding environment. (2) Those under the age of 18 or over 65, pregnant or lactating women, and those who are sensitive to anxiety. (3) Those with severe diseases such as cardiovascular, lung, liver, kidney and hematopoietic system. Psychiatric patients. (4) Those that do not meet the selection standards, do not adhere to the dosing rules, cannot determine the therapeutic effect, and have inadequate data that affect the therapeutic effect and safety judgment.

3. Observation indices (1) Contents of observation 1. Sleep time, falling asleep, arousal status, mental state after awakening. 2. Concomitant symptoms such as palpitations, headaches, dizziness, cold limbs, etc. 3. Fatigue recovery, resistance to infection, improvement of health level, general examination of blood, improvement of blood lipid and immunoglobulin. (2) Standards for judging therapeutic effects This standard was established based on the principles of clinical research guidance for insomnia new drugs in “Principles for Clinical Research in New Drugs”, p.186. 1. Symptom scoring standard (1) Speak the symptoms by yourself and record 4 points or (++). (2) If the symptom is a remarked symptom, if it is a particularly prominent or persistent symptom, score 3 points or (++). (3) Symptoms often change as they become more severe or lighter. Or, when it appears intermittently, two points or (+) are recorded. (4) If the symptom appears only occasionally, record 1 point or (±). (5) When the symptoms disappear completely, a score of 0 or (-) is recorded. 2. Therapeutic effect standard (1) Clinical cure: sleep time is restored to normal or night sleep time is kept at 6 hours or more. He sleeps well, feels good after awakening, and can work normally. Those that do not recur for more than six months. (2) Significant effect: Sleep and physical strength are clearly improved, sleep time is increased to 3 hours or more, and sleep depth is increased. (3) Effective: Symptom reduced, but sleep less than 3 hours. (4) Ineffective: Those in which neither sleep nor accompanying symptoms have been improved or worsened after treatment.

4. Methods of treatment (1) All sedatives and nourishing tonics should be discontinued in all selected cases. (2) The tablet of the composition of the present invention described above is orally administered to the observed case. Three tablets at wake-up and three tablets before bedtime, one week for four weeks. (3) The 130 selected cases are optionally divided into a treatment group and an Anjin supplementation fluid group. The administration group is 100 cases and the control group is 30 cases. (4) One ampoule is administered twice a morning and evening to the target group's brain solution. Make 4 weeks 1 cool.

5. Therapeutic effects (1) Overall therapeutic effects 1. Total effective rate and comparison of therapeutic effects with control group and control group

[0013]

[Table 1]

From Table 1, it can be seen that the composition of the present invention has a remarkable therapeutic effect on neurofunctional diseases, has a relatively high cure rate and a remarkable efficiency, and is superior to the control group as a result of statistical processing. Was. 2. Changes in sleep time before and after treatment

[0015]

[Table 2]

It can be seen from Table 2 that the sleep time was clearly increased after the treatment. As a result of the statistical treatment, a remarkable difference was observed. (2) Improvement of sleep symptoms by the composition of the present invention

[0017]

[Table 3]

As can be seen from Table 3, the composition of the present invention has a remarkable ameliorating effect on symptoms related to sleep, and a remarkable difference was observed before and after the treatment. Especially the difficulty in falling asleep again and the discomfort when waking up in the morning have been particularly improved. (3) Improvement of sleep related symptoms

[0019]

[Table 4]

As can be seen from Table 4, the symptoms associated with sleep are remarkably improved, and in particular, headache, coldness of limbs and fatigue, and improvement of helplessness are apparent. (4) Improvement of tongue and pulse before and after treatment

[0021]

[Table 5]

As can be seen from Table 5, the composition of the present invention has a remarkable effect on the tongue and pulse of the treatment group, the turnover rate is 95% or more, the control set is 75% in turnover, and the treatment set is the control set. It turns out that it is more excellent. (5) Changes in immunoglobulin before and after treatment

[0023]

[Table 6]

Table 6 shows that the composition of the present invention has a remarkable effect of increasing immunoglobulin, and is clearly improved after the treatment compared to before the treatment. (6) Improvement of blood lipids

[0025]

[Table 7]

From Table 7, it can be seen that the composition of the present invention has a marked blood lipid-reducing effect, and is improved after treatment as compared to before treatment. (7) Changes in pre- and post-treatment blood general tests Ten of the 130 patients had lower than normal levels of pre-treatment red blood cells and hemoglobin, and recovered after pre-treatment. Other 12
In 0 cases, there was no change before and after treatment.

【The invention's effect】

As described above, the composition of the present invention is effective for improving nervous function diseases and sleep symptoms.
A stress reduction effect can be obtained.

Claims (7)

[Claims] 1. A composition having a stress-reducing effect, which is mainly composed of forgetfulness. 2. A composition having a stress-reducing effect, which is mainly composed of forget-me-not and herbaceous flowers. 3. A composition having a stress-reducing effect comprising, as main components, forget-me-not, herbaceous flower, acid jujube, lily, lily flower and lotus heart. 4. A composition having a stress-reducing effect, which is mainly composed of forget-me-not grasses, hayaku flowers, acid jujubes, lilies, happi flowers, and lotus roots, and further contains one or more of the following components. Stuff. Mother of pearl, large jujube, licorice, five ginseng, eucalypt, ground yellow stalk, chrysanthemum, ox rice, ginkgo biloba, cinnabar, reishi, barley. 5. A mixture of forget-me-nots, kaya-so, acid soju and lotus root.
% Or less, 20% each for Yuri, Yuhanka, Gokasan and Pearl Mother
A composition having a stress-reducing effect, comprising 10% or less of each of barley, jujube and licorice. 6. The forgetfulness is 15 ± 5%, the flower of kaya flower, the happi flower, the mother of pearl and the ginseng are each 10 ± 5%, and the content of sojuju is 18 ± 5%.
%, Barley, jujube, and licorice, respectively, 7 ± 5%, and lily and lotus root, respectively, 3 ± 3%. 7. The composition having a stress-reducing effect according to claim 1, further comprising 5 ± 3% or less of melatonin.