JP2002275086A - Composition for improving valetudinarianish - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition which is useful for improving valetudinarianism, nourishment robustness, fatigue resistance and anemia improvement and can safely be applied. SOLUTION: This composition for nourishment robustness or valetudinarianism improvement contains Panax ginseng C.A. Mey., Equus asinus L., and either one or both of Polygonatum sibiricum Red. and Cordyceps sinensis (Berk.) Sacc. The composition for nourishment robustness or valetudinarianism improvement further contains one or more adjuvants.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD [0001] The present invention relates to a crude drug component,
The present invention relates to a composition having a nutrient tonic effect, an anti-fatigue effect, an anemia improving effect, a side effect reducing effect by administration of an anticancer agent, and a weak constitution improving effect.

[0002]

2. Description of the Related Art In modern society, life rhythms are disrupted by stress, and there are many people who feel something wrong with their bodies or suffer from lifestyle-related diseases. In adult men and women,
A high percentage of people complain of reduced energy, anemia and cold. In Western medicine, treatment using Kampo medicine has attracted attention for these symptoms, which are not considered illnesses and are hardly targeted for treatment. For nutritional tonic, recovery from fatigue, and improvement of anemia, Kampo medicine, which was born after many years of experience with the human body, is a safe and superior method, and a technology that is indispensable even in modern society. I can say.

[0003] In addition, new medicines have been developed due to advances in medicine,
In the field of cancer treatment, treatment with anticancer drugs is spreading, but the side effects of anticancer drugs are still strong. New expectations have been placed on Kampo medicines to reduce such side effects.

[0004] Conventionally, in Chinese medicine, a state of lack of energy and nutrients necessary for a person is called false evidence.
This is a general expression of pathological phenomena that appear when the individual's saneness is weak or lacks the negative fluid. Then, a replenisher is frequently added to such a state.
False evidence is distinguished as qi, blood, yin, and yang, where the replenisher is roughly divided into air respirators, blood replenishers, prosthetics, and replenishers. In view of the nutritional tonic effect, the anti-fatigue effect, and the anemia ameliorating effect, frail constitution improving agents containing several to ten or more kinds of replenishers have been taken. Typical conventional prescriptions are “Juzen Taiho-to” (composition: ginseng, sojutsu, bukuryo, licorice, peony, jihuang, kawakyu, oki, nikkei), “ninjinyoeito” (composition: toki, Ground yellow, shakuyaku, ginseng, bukuryo, white jujube, licorice, Keishi, radix, cinnabar, enshi, gomiko, ginger, dajutsu). Although traditional prescriptions have been used for a long time, their efficacy is often based on experience, but some studies have been conducted to confirm their effects ("Home Medicine Research" 17,
p. 48-52, (1998), Pharmacology and Therapy, Vol. 27, 11, (199
9)).

There are many newly developed formulas and products which are used as foods, such as garlic, as a single material ("New Drugs and Clinical Practice", Vol. 31, p. 1341-1347, (1982).
"New medicine and clinical practice", Volume 32, p. 208-219, (198
3)). On the other hand, for pharmaceuticals, many complex preparations have been developed (see “Pharmacology and Therapy”, Vol. 17, 7, p. 653-661, (198
9)), but there are parts where some side effects are a concern. There is a need for more effective ones, newer ones, and more secure ones.

[0006]

SUMMARY OF THE INVENTION An object of the present invention is to provide a highly safe composition having a nutrient tonic effect, an anti-fatigue effect, an anemia improving effect, and a weak constitution improving effect. I do.

[0007]

As a result of repeated research, the present inventor has found that ginseng (root of Panax ginseng CA Mey.), Agglutinate (skin of shaved skin of Equus asinus L.) and yellow sperm (Polygonatum sibiricum Red) Rhizome), ginseng, aglia, and Cordyceps sinensis (Berk.) Sacc.
Fruit body and sclerotia), or a composition containing ginseng, agglomerate, yellow sperm and cordyceps has a frail constitution improving effect, a high nutritional tonic effect, an anti-fatigue effect, a high anemia improving effect,
It has been found that the composition has a highly safe composition.
This composition has a higher nutritional tonic effect, an anti-fatigue effect, and an anemia improving effect than conventional formulations. It also has the effect of reducing side effects due to the administration of anticancer drugs. further,
There is no problem in safety because it uses highly safe materials that can be used as food.

That is, the present invention provides: 1. A composition for nourishing tonic or improving weakness, comprising ginseng and agglutinin, and containing one or both of yellow sperm and cordyceps. 2. The composition for nutrition or tonic or for improving weakness as described in 1, further comprising a supplement. 3. A composition for preventing fatigue, improving anemia or reducing the side effects of an anticancer agent, comprising a ginseng and an agglutinate, and including one or both of yellow sperm and cordyceps. A health food or nutritional supplement containing ginseng and glue, and one or both of yellow sperm and cordyceps, further comprising sanyak, daisies, liquorice, koui, hampi, gokahi, fenugreek, kiba, senbo, kotonik, Scallops, kukoshi, longannik, safflower, sajijin, shazin, antelope, sesame, kokuz,
A health food or nutritional supplement, comprising one or more selected from the group consisting of royal jelly, oak, peonies, plum blossoms, dolphins, citrus, plum blossoms, syrup, eucalypt, prickly pear, kashuu, pacific monkey, tossi

[0009] 5. 5. The health food or nutritional supplement according to 4, which is used for improving weakness, nourishing tonic, anti-fatigue and / or improving anemia. A medicament comprising ginseng and agglutinin, and comprising one or both of yellow sperm or cordyceps, and further comprising sanyak, daisies, liquorice, koui, hampi, kokahi,
Fenugreek, Kaiba, Senbou, Kotonik, Shikotsu, Shikoku, Ryugannik, Safflower, Soujin, Shajin, Hyakugou, Sesame, Kokuzu, Royal jelly, Ohgi, Peony, Rokujou, Koukai, Nikujuyo, Sayukou, Tokumon, Tokumoku, Juchu 6. a medicament comprising one or more members selected from the group consisting of: toukiki and gypsum; 7. The medicament according to 6, which is used for improving weakness, nourishing tonic, anti-fatigue, improving anemia and / or reducing side effects of an anticancer agent, and 3. The composition according to 1 or 2, which is in the form of a granule, a powder, a tablet, a capsule, a liquid for internal use, or a glue.

[0010]

BEST MODE FOR CARRYING OUT THE INVENTION The ginseng used in the present invention is obtained by drying the roots of Panax ginseng CA Mey. Ako is a horse donkey, Equ
It is a glue produced by boiling down the dehaired skin of us asinus L. Yellow sperm, lily family
Rhizome of ygonatum sibiricum Red. Cordyceps,
Stag beetle family Cordyceps sin
ensis (Berk.) Sacc. This sycamore is parasitic on the larvae of insects. In winter, the larvae die by absorbing the nutrients of the worms, and in summer, germinate from the heads of the worms to form rod-shaped sclerotia and become grass.

The replenisher used in the present invention is used in Chinese medicine for false verification. False evidence is a general expression of pathological phenomena caused by a state in which an individual's sanity is weak or lacks a negative fluid, and is a state of lack of energy and nutrients necessary for a person. Relief medications are considered to be qi vacancies (inadequate physiological function of the systematic organs of the human body), blood vacancies (diminished complexion caused by anemia or caused by heart and liver ataxia, decreased vision) Symptoms such as palpitations, insomnia, and dry skin), guinea (dry cough, thirst, anorexia, heartburn, etc., manifestations such as pulmonary stomach deficits, decreased vision, tinnitus, dizziness, head sway, Hepato-renal yin imaginary symptoms, etc.), and yang yang (mainly kidney yang imaginary, a symptom of decline in systemic function). Drugs are divided into four types.

[0012] As a replenisher, sanyak, daisies, licorice, cucumber, hampi, kokahi, fenugreek, kaiba, senbo, kotounik, shikotsu, kukushi, ryugannik, safflower, soujin, shajin, hyakugo, sesame, kokuz, royal jelly, ougi, Peonies, Lokujo, Goukai, Nikujuyou, Sayou, Eucommia, Jukujiou, Kashuu, Bakumondou, Toshishi,
You can use touki and red pepper.

[0013] Sanyak, daisies, liquorice, koui,
Ogi and peonies are also known as respiratory medicines, such as Hampi, Kokahi, Fenugreek, Kaiba, Senbou, Kotonik, Shikotsushi, Rokujo, Gougai, Nikujuyo,
Sayou, Eucommia, and Toshishi are kokushi,
Longan garlic, safflower, soujin, jukzio,
Kash 、 and Touki are blood-supplementing drugs, such as ジ ン azin, Zygów, Sesame, Kokuz 、, Royal Jelly, Bakumondou,
Seccok is known as a prosthetic.

[0014] Sanyak is a dried product of the tuberous root of Yamaceae, and daisy is a dried product of the buckthorn family, Satsuma jujube and its congener plants. Licorice is a dried product of the roots and rhizomes of the leguminous family Urallizo, and Koui is a candy that is processed and produced by adding malt to glutinous rice flour, floury rice flour, and flour. Hampi is the viper of the viper, a viper of the Viperidae, which is peeled, stretched and dried. Gokahi is made by drying the root bark of Gokogi family of fine columns or red hair. Fenugreek is the seed of the leguminous fenugreek. Kaiba,
It is a dried product excluding the guts of the Giant Fish and the spotted hippocampus.

[0015] Sengoku is obtained by drying the rhizome of the Amaryllidaceae, Quercus serrata. Kotonik is dried seeds of walnut Kotonik seeds. Sorghum is a dried version of the mature fruit of the leguminous humus. Kukoshi is a dried product of mature fruits of Solanaceae wolfberry. Longan garlic is the pulp of longan longan. Safflower is a dried flower corolla of Asteraceae. Sojin is a mature fruit of the mulberry family Magwa. Shajin is obtained by drying the roots of the Apiaceae family Hamabofu. Antelope is dried lily bulb of the lily family Antelope. Sesame is obtained by drying black seeds of the sesame sesame. Kokuzuku is a seed of legume soybean. Royal jelly is a milky substance secreted by the young worker bee from its hypopharyngeal line and the whale gland for breeding queen bees. The onions are dried roots of the leguminous yellowtail.

The peony is obtained by removing the outer skin of the root of the peony peony. Lokjou is a processed adult horned deer with finely haired, ossified heads of male Sika deer and Sika deer. Goukai is a dried gecko gecko whose guts are removed.
Nikujuyo is obtained by drying the fleshy stalks of Honokuiku, which is a family of the family Antrodiaceae. Sayou is obtained by drying the fleshy stalks of Antrodiaceae.

Eucommia is obtained by drying the stem bark of Eucommia eucommia. Jukuujiou is made by repeating the process of drying the rhizome of Scrophulariaceae, Oysteriasis, adding liquor, steaming, and then drying it in the sun. Kashuu is a dried mass of roots of the Polygonaceae turkudokumi. Bakumondou is a dried form of the root of the lily family Janohige. And the red pepper is a fresh or dried stem of the orchid red pepper. Toshishi is obtained by drying mature seeds of Convolvulaceae and P. serrata. Touki is obtained by drying the roots of Aceraceae.

These components can be used by pulverizing them to obtain a pulverized product and then as a powder according to the form and intended dosage form, or by extracting with ethanol or hot water. It can be used as an extract, as a dry extract and dried extract, and further as a powder.

As these components used in the present invention, commercially available components can be used.

[0020] These are ginseng, agglutinate, and yellow spirit, 2 to 20
w / w%, Cordyceps, 1-10 w / w%, Sanyaku, Taisou, Hampi, Fenugreek, Kaiba, Kukushi, Ryugannik, Safflower, Soujin, Peony, Nikuju,
It is preferable to add 1 to 20 w / w% of Toshishi and Touki. Licorice, Koui, Scarlet, Senbo, Kotonik, Sukutushi, Shajin, Hyakugo, Sesame, Kokuz, Royal Jelly, Goat, Rokujo, Gokai,
It is preferable to mix 1-20 w / w% of Sayou, Eucommia, Jeuxiao, Kash, Bakumondou, and Ginkgo.

The composition of the present invention, comprising ginseng and agglutinate, and comprising one or both of yellow and cordyceps,
It is effective for restoring fatigue due to stress and aging and improving anemia, and can be used for nutritional tonic, anti-fatigue and anemia improvement. A composition comprising ginseng and agglomerates, and comprising one or both of yellow sperm or cordyceps,
It has the effect of increasing vitality and balancing the body.
It can be used to improve weakness. Furthermore, it can be used by incorporating a replenisher.

The composition of the present invention, comprising ginseng and agglutinate and comprising one or both of yellow sperm and cordyceps,
It also has the effect of reducing the side effects of anticancer drugs, and can be used to reduce the side effects of anticancer drugs.

The composition for improving weakness can be used as a medicine, a quasi-drug, or a food such as a health food or a dietary supplement, and further, may be used as other food materials, ingredients or vitamins. It is possible to mix various medicinal ingredients and crude drug components. As food, its effectiveness can be fully demonstrated, and it is highly safe.

In addition to the above composition, sanyak, daisy, liquorice, cucumber, hampi, kokahi, fenugreek, kaiba, senbo, kotonik, shikotsushi, kukoshi, ryugannik, safflower, sojin, shajin, gyakugo, sesame, kokuzu, royal jelly Containing at least one selected from the group consisting of: ogre, peonies, peonies, rouge, goukai, nutmite, sayou, eucalypt, jukjiou, kashuu, bakmondou, toshishi, toukiki and cedar, health foods, dietary supplements, quasi-drugs, It can be used as a medicine.

[0025] In particular, goats, peonies,
Those containing squid, citrus, sycamore, eucommia, jukjiou, kashu, bakmondondo, and gypsum can be used as a medicine. In this case, it can be used as a drug or a quasi drug.

The composition of the present invention can be made into various dosage forms usually used in health foods and pharmaceuticals, such as tablets, capsules, powders, granules and liquids for internal use. It may be used orally as it is. For the formulation, a formulation technique that is usually employed in the fields of health foods and medicines can be applied. Further, if necessary, additives for formulation,
For example, excipients, lubricants, binders, antioxidants, coloring agents,
A surfactant and the like can be blended, and a coated tablet can be prepared using a coating agent.
It can also be a paste-like glue.

When a solid preparation such as a tablet is prepared, ginseng is extracted with 10-75% alcohol, the extract is separated by filtration, and other crude drugs such as yellow sperm other than cordyceps are added to the residue. It is extracted with hot water and the extract is separated by filtration. Ginseng alcohol extract (Ginseng extract), hot water extract of yellow spirit and other compounded crude drugs (mixed crude drug extract), mixed with ginseng residue and dried, dried extract (Crude drug extract dried extract) Can be used. Cordyceps can be ground and the powder can be used directly in the formulation. In the case of a liquid preparation, Cordyceps sinensis can be extracted with hot water together with other compounded crude drugs such as yellow sperm, and the liquid extract can be used for producing a liquid preparation. Agglomerate can be dissolved in hot water and mixed with ginseng extract, yellow sperm and other blended herbal extracts to be used in solid preparations and liquid preparations.

The daily intake of the composition of the present invention for an adult is preferably in the range of 1 to 6 g corresponding to a dry crude drug. However, the amount of the composition to be applied may be appropriately determined according to the age, sex, body weight and symptoms of the subject. Can be set.

[0029]

Embodiments of the present invention will be described below in detail. Example

Cellulose, lactose, starch, dietary fiber, vegetable oil and fat, shellac, and guar gum were blended with the following crude drug component formulations A and B (corresponding to Examples 1 and 2, respectively), and tablets (formulation A: 240 mg) / Particle, Formulation B: 290 mg / particle). In Test 1, this tablet was used.

In Tests 2 to 4, aqueous solutions of the crude drug extracted and dried extracts of the following crude drug components A and B (corresponding to Examples 1 and 2, respectively) were used.

As a control, a commercially available nutritional tonic (50 ml of drink) was used. The crude drug component formulation corresponds to the following control formulation.

(Formulation A) Ginseng 16w / w%, Agar 4w / w%, Yellowseed 8w / w%, Cordyceps 2w / w%, Sanyak 4w / w%, Hampi
12w / w%, Fenugreek 12w / w%, Kaiba 4w / w%, Sanshuyu 1
2w / w%, caffeine 4w / w%, kukoshi 12w / w%, turmeric 4w / w
%, Sunsownin 4% w / w, thimpi 2% w / w.

(Prescription B) Ginseng 16w / w%, Agar 12w / w%, Yellow Sperm 12w / w%, Cordyceps 1w / w%, Sanyak 8w / w%, Hampi 8
w / w%, Kaiba 4w / w%, Cahig 4w / w%, Kukoshi 12w / w
%, Turmeric 4w / w%, sansonin 4w / w%, thimpi 1w / w
4% w / w, 4% w / w safflower, 4% w / w safflower
w%, Ryugannik 2w / w%

Control formulation (commercial drink) Cistanche salsa 8.85 w / w%, Muirapuama 5.31 w / w%, Kaikujin 1.77 w / w%, Jajoushi 5.31 w / w%, Toshishi 5.31
w / w%, Eucommia 5.31w / w%, Rokujo 5.31w / w%, Epimedium 17.7w / w%, Carrot 10.62w / w%, Sanyak 5.3
1w / w%, Jiaowei 5.31 w / w%, Hampi 4.42 w / w%, Sanshuyu 8.85 w / w%, Garishi 5.31 w / w%, Bukuroyou 5.31 w
/ w%

Test 1 Clinical Evaluation (Subject) The subject has fatigue or anemia such as fatigue, physical weakness, loss of appetite, dizziness, and poor blood color.
40 adult males and females of 60 years old. (Test Materials) Tablets according to the crude drug component formulation A, tablets according to the formulation B (Examples 1 and 2), and commercially available drinks (50 ml / piece) as control formulations were orally administered. (Test method and period of intake) The subjects were divided into 4 groups of 10 persons, and the placebo group taking placebo and the control
The control group ingesting one bottle per day (equivalent to 5.65 g of dry crude drug), 6 tablets of formulation A of the Example per day (3 g of dry crude drug)
) And Group B consuming six tablets of formulation B per day (corresponding to 3 g of dry crude drug). The intake period was two weeks. At the start and at the end, subjective symptoms were investigated. The effect was judged from the change in the subjective symptoms. The survey items were general malaise, laxity of legs and legs, eye fatigue, dizziness and dazzling, and poor blood color. The degree of improvement of each symptom was 1. Significant improvement; Moderate improvement; Mild improvement,
4. Unchanged, 5. Evaluation was made in five stages of deterioration. (Results) Table 1 shows the results. The A and B groups (Examples 1 and 2) that took the tablets of Formula A and Formula B showed a marked improvement over the placebo group. Improvements were seen to the same degree or better than the control formulation.

[0037]

[Table 1] Test 2 Fatigue test using mice (test material) The no-administration group was used as a control, and the group A was orally administered, and the group A was a control formulation (commercial drink 10 ml / kg / da)
y) was administered, and group B was treated with the herbal extract-dried extract 11 of formula A.
5 mg (dry weight) / kg / day was administered as an aqueous solution, and group C was 160 mg (dry weight) of crude extract extracted dry extract of formula B /
kg / day as an aqueous solution (Example 1 respectively)
And 2). (Test animals) Ten ddY mice 6 weeks old were used per group. (Test method) After a one-week observation period, the test material was orally administered once a day. The administration period was 21 days in total.
The forced swimming time limit test was performed on the 0th day, the 7th day, the 14th day, and the 21st day of administration. One hour after the administration of the test substance, 10% of the body weight was placed in a constant temperature water bath at a water depth of 22 cm and a water temperature of 26 ° C.
The mice loaded with the weight of were allowed to swim, and the time from the start of swimming until the head was submerged under water for 5 seconds was measured. (Test Results) The results are shown in FIG. Group A (control formulation),
In Group B (Example 1) and Group C (Example 2), the forced swimming time was prolonged at 7, 14, and 21 days after administration of the test substance, as compared to the control group. In addition, the extension of the forced swimming time of the group B (Example 1) and the group C (Example 2)
It was found to be more remarkable than the group (control formulation), indicating that the effect was superior.

Test 3 Anemia test using rats (Test material) An untreated group was provided, a non-administered group was used as a control, and a group A was orally administered a commercially available drink (4.5 ml / kg / day) of a control formulation. Group B is administered as an aqueous solution of 55 mg (dry weight) / kg / day of a crude drug extract / dry extract of Formula A, and Group C is 75 mg of a crude drug extract / dry extract of Formula B
(Dry weight) / kg / day was administered as an aqueous solution. (Test animals) Ten 7-week-old Wister rats were used per group. Approximately 3.5 ml of blood was excreted once every two days to the Wister rats other than the untreated group every two days until the state became anemic, and the erythrocytes and hemoglobin in the blood were reduced to prepare an anemia model. (Test Method) After a one-week observation period, the test material was orally administered once daily for 15 days. Hematology: Blood was collected at 5 day intervals and hematological measurements were taken. (Blood red blood cell count RB
Indicated by C / L. (Test results) The results are shown in FIG. Group A (control formulation),
In group B (Example 1) and group C (Example 2), the number of red blood cells increased on the 5th, 10th, and 15th days after administration of the test substance, as compared with the control group. And group C recovered to the same level as the control group. Group B, C
The erythrocyte count of the group (Examples 1 and 2) was found to be more remarkable than that of the group A (control formulation), indicating that the effect was superior.

Test Example 4 Leukopenia Inhibition Test (Test Material) An untreated group was provided, a non-administered group was used as a control, and a commercially available drink was orally (4.5 ml / kg / day).
Group B, the herbal extract dry extract of Formula A 55 mg
(Dry weight) / kg / day was administered as an aqueous solution, and Group C was 75 mg (dry weight) / dry extract of crude drug extracted from Formulation B
y was administered as an aqueous solution. (Test animals) Ten 7-week-old Wister rats were used per group. Wister rats other than the untreated group were intraperitoneally injected with 10 mg / kg of the anticancer drug endoxane to reduce white blood cells in the blood, thereby preparing a low leukocyte experimental model. (Test method) The test material was orally administered once a day for 15 days. Hematology: Blood was collected at 5 day intervals and hematological measurements were taken. (Indicated by blood white blood cell count WBC / L.) (Test results) The results are shown in FIG. Group A (control formulation),
Group B (Example 1) and Group C (Example 2) showed that the leukocyte count in the administration group was significantly increased and recovered 15 days after administration of the test substance, as compared with the control group.

[0040]

Industrial Applicability According to the present invention, a composition containing a crude drug component, which is safe and has excellent nutrient tonic action, anti-fatigue action, and anemia improving action, a composition having a weak constitution improving action, food, medicine, Further, a composition having an effect of reducing the side effects of an anticancer agent is provided.

[Brief description of the drawings]

FIG. 1 shows the results of a fatigue test based on changes in swimming time using mice.

FIG. 2 shows the results of an anemia improvement test using anemic rats.

FIG. 3 shows the results of a test for change in blood leukocyte count using leukopenia-treated rats treated with an anticancer drug.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61K 35/84 A61K 35/84 Z A61P 3/02 A61P 3/02 7/06 7/06 (72) Invention Person Yoshimitsu Takai 12-13, Kashina, Totsuka-ku, Yokohama-shi, Kanagawa Prefecture F-term in FANCL Central Research Laboratory 4B018 MD61 MD64 MD82 ME02 ME08 ME14 4C087 BB21 BB22 BB32 BB48 MA02 NA14 ZA55 ZC21 4C088 AA01 AA02 AB12 AB16 AB18 AB18 AB30 AB32 AB37 AB41 AB43 AB48 AB59 AB60 AB74 AB82 AB84 AB85 AB89 AD10 AD12 AD14 AD19 BA08 MA07 MA08 MA52 ZA55 ZC21

Claims (8)

[Claims] 1. A composition for nourishing tonic or improving weakness, comprising ginseng and agglutinate, and containing one or both of yellow sperm and cordyceps. 2. The composition according to claim 1, further comprising a replenisher. 3. A composition for preventing fatigue, improving anemia or reducing side effects of an anticancer agent, comprising a ginseng and an agglutinate, and containing one or both of yellow sperm and cordyceps. 4. A health food or nutritional supplement containing ginseng and agglutinin, and containing one or both of yellow and green caterpillars, further comprising sanyak, sisou, licorice, cowi, hampi, kokahi, fenugreek, kaiba. , Senbou, Kotonik, Shikotsu, Shikoku, Ryugannik, Safflower, Soujin, Shajin, Hyakugo, Sesame, Kokuzu, Royal jelly, Ougi, Peony, Rokujou, Gokai, Nikuju, Sayou, Eucommia, Kudo, Mongolia
A health food or a dietary supplement comprising one or more selected from the group consisting of touki and gypsum. 5. The health food or nutritional supplement according to claim 4, which is used for improving weakness, nourishing tonic, anti-fatigue and / or improving anemia. 6. A medicament comprising ginseng and agglomerate, and containing one or both of yellow or cordyceps, further comprising sanyak, daisies, liquorice, koui, hampi, gokahi, fenugreek, kiba, senbo, kotonik,
Skull, Kukoshi, Ryugannik, Safflower, Soujin, Shajin, Hyakugo, Sesame, Kokuz, Royal Jelly, Forsythia, Peonies, Lokujo, Gokukai, Nikujuyo, Sayou, Tokushu, Jukujio, Kashou, Bakumondou, Toshikoshi A medicament comprising one or more selected. 7. The medicament according to claim 6, which is used for improving weakness, nourishing tonic, anti-fatigue, improving anemia, and / or reducing side effects of an anticancer agent. 8. The composition according to claim 1, which is in the form of a granule, a powder, a tablet, a capsule, an oral solution or a glue.