CN103355655A - Composition with alimentary anemia improving function and preparation method of composition - Google Patents
Composition with alimentary anemia improving function and preparation method of composition Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition with an alimentary anemia improving function and a preparation method of the composition. The composition is prepared from astragalus membranaceus, codonopsis pilosula, angelica, jujube and prepared rehmannia root according to a certain weight percentage, and the composition can be prepared into any commonly used preparation, preferably an oral preparation. The pharmaceutical composition has a function of improving alimentary anemia.
Description
Technical field
The present invention relates to a kind of composition and method of making the same that improves the alimentary anemia function that has, belong to the technical field of health food.
Background technology
Anaemia refers to that the red blood cell total alkali is reduced to below the normal value in the systemic circulation blood.The incidence of disease of anaemia is high, comprises four kinds of hypoferric anemia, giant cell anaemia, alpastic anemia and hemolytic anemias.Modal is hypoferric anemia, take children and pregnant woman's incidence of disease as high.
The weight of Anemia depends primarily on the degree of anaemia and produces reason and the speed of anaemia, and the faster symptom of speed that produces anaemia is more serious, and the anaemia that slowly occurs is because the adaptation of human body and compensatory, and symptom is relatively light.Anaemia can be caused that by many reasons the life-span of red blood cell in blood circulation is approximately 120 days, and old and feeble red blood cell mainly is eliminated in spleen.Marrow is that the adult makes erythrocytic factory, constantly is transported to after the maturation in the blood circulation, and red blood cell and Lactoferrin amount is constant in the maintenance blood circulation.Thereby red blood cell generates minimizing or the red blood cell loss too much is the two large reasons that produce anaemia.Red blood cell generates the minimizing hemopoietic function of bone marrow and goes down, and can cause alpastic anemia or Pure red cell aplasia; Marrow is encroached on by abnormal structure, causes myelophthisic anemia.Owing to just children and the gravidic women of growth and development stage, need more iron on the physiology, and lack enough ironys in the daily food, so hypoferric anemia is again alimentary anemia.Traditional Chinese medicine thinks that blood derives from spleen to categories such as this disease ownership " consumptive disease ", " deficiency of blood ", and is at all not enough at kidney and the source of vital function, produces anaemia.Deficiency of blood the five internal organs lose supports, and just deficiency of heart-blood can occur, the liver kidney two empty common symptons that wait.
Show that according to investigations alimentary anemia is one of human four large nutritive diseases, a series of diseases that cause have thus reduced people's quality of life, brought misery for people's life, and the incidence of disease of countries in the world are all very high.Although the improvement along with living condition, people's food quality is significantly improved, but because people are not enough to the knowledge of alimentary anemia understanding, diet structure is unreasonable and most of crowd's partial eclipse, apocleisis, the bad life habits such as particular about food, so that the incidence of disease of alimentary anemia is still high.The function of the nutritious and moist whole body of blood, anaemia or the deficiency of blood can occur that dizzy order flower, sallow complexion, the lazy speech of few food, the withered flesh of hair are dry, extremity numbness etc., severe patient even forgetful, insomnia, the symptom such as wandering occur.Therefore prevent alimentary anemia to be even more important.
Summary of the invention
The object of the invention has provided a kind of composition that improves the alimentary anemia function that has.
Another object of the present invention has provided the preparation method of said composition.
The present invention is achieved by the following technical solutions:
The present invention is made by the raw material of following weight parts:
Radix Astragali 1-30 part, Radix Codonopsis 1-20 part, Radix Angelicae Sinensis 1-20 part, date 5-30 part, prepared rhizome of rehmannia 1-15 part.
Be preferably:
Radix Astragali 10-20 part, Radix Codonopsis 5-10 part, Radix Angelicae Sinensis 5-10 part, date 15-20 part, prepared rhizome of rehmannia 3-8 part.
Can also add iron enriched nutrient 1-10 part among the present invention, preferred iron enriched nutrient 3-6 part.
The mechanism of action of each component is as follows among the present invention:
The Radix Astragali: traditional Chinese medicine thinks that the Radix Astragali has the effect of tonifying Qi and lifting yang, strengthening exterior and reducing sweat, pus draining and toxin expelling, inducing diuresis for removing edema, expelling pus and promoting granulation.Modern pharmacological research shows, contain the various bioactivators such as polysaccharide, protein, alkaloid, amino acid, flavonoids, glucoside, trace element in the Radix Astragali, has the enhanced machine body immunity function, the effect such as cardiac stimulant step-down, hypoglycemic, diuresis, anti-ageing, antifatigue, antitumor, antiviral, calm, analgesia.
Radix Codonopsis: be the root of Campanulaceae Radix Codonopsis, element flower Radix Codonopsis, radix codonpsis tangshen, pipe flower Radix Codonopsis, C. subglobosa, C. canescens.Have tonifying middle-Jiao and Qi, the effect of invigorating the spleen benefit lung is used for a little less than the spleen deficiency syndrome of the lung, the palpitaition of breathing hard, and anorexia and loose stool, void is breathed with cough and is coughed, and interior heat is quenched one's thirst etc.Test demonstration, rabbit hypodermic injection Radix Codonopsis aqueous extract and pure medicinal extract or the codonopsis pilosula powder of feeding can make red blood cell number raise, and leukocyte count descends, and be oral remarkable than hypodermic injection effectiveness.Rabbit hypodermic injection Radix Codonopsis decocting liquid also can make red blood cell number and content of hemoglobin significantly increase.Render a service obviously behind the excision animal spleen and reduce, show that the influential spleen of Radix Codonopsis promotes erythropoietic effect.To the mouse stomach asiabell preparation, red blood cell number and content of hemoglobin are obviously risen, reticulocyte counts and lymphocyte number are had no significant effect.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, and the effect that relaxes bowel is used for sallow, the dizzy palpitaition of the deficiency of blood, irregular menstruation, through closing dysmenorrhoea, asthenia cold abdominalgia, the dry constipation of intestines, arthralgia due to wind-dampness, injury from falling down, ulcer sores.Early stage report shows that the Radix Angelicae Sinensis infusion can significantly promote hemoglobin and erythrocytic generation to mouse po, its anti-anaemia effect may with contained cobalamin. the compositions such as nicotinic acid, folinic acid and biotin, folic acid are relevant.Nearer studies show that, sodium ferulate has anti-O2 and H2O to erythrocytic oxidation, and membrane lipid Peroxidation Product MDA is reduced, and can obviously reduce the haemocylolysis that is caused by MDA.In the presence of sodium ferulate, sickle anaemia erythrocyte lipid peroxidation in patients thing MDA increases with sodium ferulate concentration and reduces, and sodium ferulate can obviously reduce complement hemolysis, suppresses the combination of complement component 3 b (C3b) and erythrocyte membrane; On complement activation and erythrodegeneration without impact.Radix Angelicae Sinensis polysaccharide can increase peripheral red blood cells, leucocyte, hemoglobin and bone marrow nucleated cell number, this effect particularly PBC reduce and marrow particularly evident when being suppressed.
Date: the treatment that is mainly used in the cards such as the deficiency of qi in middle-jiao, weakness of the spleen and the stomach, fatigue and asthenia, anorexia and loose stool, the deficiency of blood are sallow, women's hysteria.Pharmacological research is found in recent years, contain various bioactivators in the date, such as date polysaccharide, flavonoids, saponins, triterpenes, alkaloids, CAMP (cAMP), cyclic GMP concentration (cGMP) etc., human body there is the plurality kinds of health care effect of curing the disease. date has the effects such as qi-restoratives benefit gas, nourishing blood and tranquilization, strengthening the spleen and stomach, is the good health nutrients of patient such as weakness of the spleen and the stomach, insufficiency of vital energy and blood, lassitude, insomnia and dreamful sleep.
Prepared rhizome of rehmannia: concoct through processing for the piece root of scrophulariaceae rehmannia glutinosa plant (Rehmannia glutinosa (Gdertn) Iibosch.exFisch.et Mey.) and to form.Have enrich blood moist; The effect that the benefit essence is filled out marrow, it is sallow to be used for the deficiency of blood, dizzy palpitaition, irregular menstruation, liver-kidney Yin deficiency, hectic fever night sweat, the seminal emission impotence, infertility, irregular menstruation, metrostaxis, soreness and weakness of waist and knees, Hiccough and deaf, the head is dim-sighted, and poliosis is quenched one's thirst, constipation, the syndrome characterized by dyspnea of suffering from a deficiency of the kidney.Pharmacological action shows that the water decoction gavage awards mouse and observes the impact that blood loss anemia, candidate stem cell and marrow hemopoietic progenitor cell of red blood cell line CFU-E are generated.The result: living, ripe bosom glutinous rehmannia has obvious effect to losing blood property mouse, and administration is after 8 days, and particularly the prepared rhizome of rehmannia group recovers very fast, substantially recovers, and RBC and Hb counting are respectively 0.001 and 0.01 with control group comparison P value.Give birth to, prepared rhizome of rehmannia also has certain propagation, differentiation to candidate stem cell, promote the product of haemocyte like yellow blood tonification effect accountably and candidate stem cell: life is relevant.Generation to mouse bone marrow cells erythroid hematopoiesis group cell: the red assembly of physiological saline group fall (number) be 52.4 ± 18.41, the dried rhizome of rehmannia and cultivated land group are respectively 60.2 ± 19.44 and 125 ± 20.45 (P＜0.05).Prompting glutinous rehmannia blood tonification effect and medulla hematopoietic system also have closely-related effect.
It is remarkable to improving the hypoferric anemia effect that the present invention selects Chinese medicine and chalybeate compatibility to use, and the experimenter takes in behind chalybeate or the Chinese medicine associating chalybeate its routine blood test and biochemical indicator and have no significant effect, and illustrate that it is a kind of safe product of enriching blood that Chinese medicine is united chalybeate.Five kinds of Chinese medicines cooperate chalybeate to use, and are that the present invention has the good effect that improves alimentary anemia.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into the preparation of any routine, comprises oral formulations, external preparation, injection.For example these bulk drug pulverizes can be mixed; The alcohol extract that the bulk drug of described weight portion can be added respectively water or variable concentrations, the extract concentrate drying gets crude extract, or employing process for purification, for example, water extraction and alcohol precipitation method, organic solvent extractionprocess, column chromatography, carbon dioxide supercritical extraction method, steam distillation are made with extra care and are obtained extract.
When stating medicine in the use, the medicine that both can adopt to be equivalent to described weight proportion is that raw material cleans respectively, and is dry, pulverize, be mixed to get the particle or the powder that meet preparation requirement granularity and directly take.The medicine that also can adopt to be equivalent to described weight proportion relation is that raw material adds pharmaceutic adjuvant after suitably processing, and is made into as required various preparations.Be prepared into by the above-mentioned raw materials medicine in the process of preparation, the above-mentioned raw materials medicine can adopt following method to process: add respectively the alcohol extract of water or variable concentrations, the extract concentrate drying gets crude extract; Or further adopt alcohol deposition method, water back dissolution method, organic solvent extractionprocess, flocculent precipitation, column chromatography one or more unite and use after suitably making with extra care to get extract; Adoptable concrete operations and/or using method when above-mentioned effective medicinal ingredient is extracted, both can be that drug ingedient take described each proportional quantities is as raw material, extract respectively decomposite mode behind its effective medicinal ingredient, also can adopt each medicine material by said proportional quantities to mix after the common mode of extracting again.Adopt different extraction means, equipment and actual conditionses such as required desirable or best extraction temperature, solvent load, extraction time, extraction time when extracting, then can be according to actual conditions by testing screened and finding.
Better bring into play drug effect for each raw material that makes this medicine, preferably the raw material of proportioning of the present invention carried out alcohol extracting, but can not be used for restriction protection scope of the present invention.
The preparation method of the present composition is as follows:
The Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, date, prepared rhizome of rehmannia with described weight proportion, add 6-12 and doubly measure the 50-95% alcohol extract 1-4 time, each 1-3 hour, extract merged, and filtered, decompression recycling ethanol is to thick paste, drying under reduced pressure is ground into fine powder, adds iron enriched nutrient, mixing namely gets the active component of medicine of the present invention.
The preparation method of the present composition can also for:
With the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, date, the prepared rhizome of rehmannia of described weight proportion, add 6-12 times of water gaging and extract 1-4 time, each 1-3 hour, extract merged, filter, filtrate is concentrated into thick paste, and drying is ground into fine powder, add iron enriched nutrient, mixing namely gets the active component of medicine of the present invention.
The active constituents of medicine of the present invention that makes can directly be used as medicine take or add on the pharmacy acceptable auxiliary material routinely technique be prepared into required preparation.As making the oral drugs of the solid pharmaceutical preparation forms such as tablet commonly used (dispersing tablet, effervescent tablet, oral disnitegration tablet, lozenge, chewable tablets, effervescent tablet), capsule (hard shell capsules, soft capsule), granule, pill (pill), powder, also can make the oral drugs of the liquid preparation forms such as syrup, oral liquid; Can also make the external used medicine of the external preparation forms such as paste, gel, ointment, cataplasm, emplastrum, liniment, lotion, plastics.Therefore, except active ingredient, can also contain pharmaceutically acceptable auxiliary material in this pharmaceutical composition.
Auxiliary material described here can be different according to different preparations, such as diluent commonly used in the solid pharmaceutical preparations such as tablet, capsule, granule, disintegrant, excipient, adhesive, lubricant, surfactant, filler etc.; The surfactant of in the liquid preparation forms such as syrup, oral liquid, commonly using, diluent, anticorrisive agent, stabilizing agent, flavouring, thickener, glidant etc.; The medicinal oleaginous base of in the external preparation forms such as gel, ointment, commonly using, aqueous matrix, anticorrisive agent, antioxidant, NMF, skin penetration enhancer, surfactant etc.
Its auxiliary material commonly used such as starch, lactose, dextrin, Icing Sugar, microcrystalline cellulose, sweet mellow wine, xylitol, polyethylene glycol, calcium sulfate, calcium monohydrogen phosphate, calcium carbonate, modified starch, sorbierite, polyvinyl pyrrolidone, heavy magnesium carbonate, sodium carboxymethylcellulose, HPMC, methylcellulose, ethyl cellulose, carboxyrnethyl starch sodium, hydroxypropyl cellulose, PVP K30, white bole, pregelatinized starch, dolomol, talcum powder, superfine silica gel powder, stevioside glycosides, betaine, aspartame, glycyrrhizin, saccharin sodium, citric acid, sodium acid carbonate, sodium carbonate, carragheen, agar, gelatin, sodium alginate, xanthans, guar gum, tragcanth, Arabic gum, locust bean gum, Karaya Gum, stearic acid, glycerin monostearate, polyacrylamide, cross linked sodium polyacrylate, polyvinyl alcohol, carbomer, sorbic acid, potassium sorbate, ethyl hydroxy benzoate, phenmethylol, nipalgin, thimerosal, dimethyl sulfoxide (DMSO), azone, triethanolamine, NaOH, glycerine, propane diols, BHT, BHA, lauryl sodium sulfate, Tweens, spans etc.
For preparation above-mentioned, preferred particulates agent of the present invention, the preparation method is as follows:
With the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, date, the prepared rhizome of rehmannia of described weight proportion, add 8 times of amount 70% alcohol extracts 3 times, each 1.5 hours, extract merges, and filters, and decompression recycling ethanol is to thick paste, drying under reduced pressure is ground into fine powder, adds iron enriched nutrient, mixing adds appropriate amount of auxiliary materials, mixing, with 85% alcohol granulation, drying, whole grain, and get final product.
The present invention relates to a kind of composition be used to improving alimentary anemia, contain traditional blood tonic of high-quality, add simultaneously iron enriched nutrient, is that negative and positive are all mended, and qi and blood is two to be treated, but the Effective Raise immunity of organisms has blood tonification effect.
The specific embodiment
Embodiment 1:
Radix Astragali 150g, Radix Codonopsis 75g, Radix Angelicae Sinensis 75g, date 175g, prepared rhizome of rehmannia 55g
Take by weighing the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, date, the prepared rhizome of rehmannia of described weight proportion, add 8 times of amount 70% alcohol extracts 3 times, each 1.5 hours, extract merges, and filters, and decompression recycling ethanol is to thick paste, drying under reduced pressure is ground into fine powder, adds sucrose, aspartame, dextrin is an amount of, mixing is with 85% alcohol granulation, drying, whole grain namely gets granule.
Embodiment 2:
Radix Astragali 10g, Radix Codonopsis 200g, Radix Angelicae Sinensis 10g, date 300g, prepared rhizome of rehmannia 10g
Take by weighing the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, date, the prepared rhizome of rehmannia of described weight proportion, add 12 times of amount 50% alcohol extracts 2 times, each 2 hours, extract merges, and filters, and decompression recycling ethanol is to thick paste, drying under reduced pressure, be ground into fine powder, add lactose, sweet mellow wine is an amount of, mixing, with 85% alcohol granulation, drying, whole grain namely gets granule.
Embodiment 3:
Radix Astragali 300g, Radix Codonopsis 10g, Radix Angelicae Sinensis 200g, date 50g, prepared rhizome of rehmannia 150g
Take by weighing the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, date, the prepared rhizome of rehmannia of described weight proportion, add 6 times of amount 95% alcohol extracts 4 times, each 1 hour, extract merges, and filters, and decompression recycling ethanol is to thick paste, drying under reduced pressure, be ground into fine powder, add microcrystalline cellulose, lactose is an amount of, mixing, granulate, drying, whole grain namely gets granule.
Embodiment 4:
Radix Astragali 100g, Radix Codonopsis 100g, Radix Angelicae Sinensis 50g, date 200g, prepared rhizome of rehmannia 30g
Take by weighing the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, date, the prepared rhizome of rehmannia of described weight proportion, add 10 times of amount 80% alcohol extracts 3 times, each 1 hour, extract merges, and filters, and decompression recycling ethanol is to thick paste, drying under reduced pressure is ground into fine powder, and it is an amount of to add sodium carboxymethyl starch, superfine silica gel powder, microcrystalline cellulose, PVPP, mixing is granulated drying, add dolomol, mixing, compressing tablet, dressing or dressing not namely get tablet.
Embodiment 5:
Radix Astragali 200g, Radix Codonopsis 50g, Radix Angelicae Sinensis 100g, date 150g, prepared rhizome of rehmannia 80g
Take by weighing the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, date, the prepared rhizome of rehmannia of described weight proportion, add 7 times of amount 60% alcohol extracts 1 time, each 3 hours, extracting liquid filtering, decompression recycling ethanol is to thick paste, drying under reduced pressure is ground into fine powder, adds appropriate amount of auxiliary materials, mixing, granulate, drying, encapsulated, namely get capsule.
Embodiment 6:
Radix Astragali 20g, Radix Codonopsis 180g, Radix Angelicae Sinensis 20g, date 280g, prepared rhizome of rehmannia 20g
Take by weighing the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, date, the prepared rhizome of rehmannia of described weight proportion, add 8 times of water gagings and extract 3 times, each 2 hours, extracting liquid filtering was concentrated into thick paste, and drying under reduced pressure is ground into fine powder, adds right amount of auxiliary materials, and mixing is made pill.
Embodiment 7:
Radix Astragali 280g, Radix Codonopsis 20g, Radix Angelicae Sinensis 180g, date 60g, prepared rhizome of rehmannia 140g
Take by weighing the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, date, the prepared rhizome of rehmannia of described weight proportion, add 8 times of amount 60% alcohol extracts 3 times, each 2 hours, extracting liquid filtering, Recycled ethanol is to distinguishing the flavor of without alcohol, suitably concentrated, add an amount of supensoid agent, flavor enhancement, anticorrisive agent, mixing, add the water constant volume, filter, packing namely gets oral liquid.
Embodiment 8:
Radix Astragali 150g, Radix Codonopsis 100g, Radix Angelicae Sinensis 100g, date 175g, prepared rhizome of rehmannia 70g
Take by weighing the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, date, the prepared rhizome of rehmannia of described weight proportion, add 12 times of water gagings and extract 2 times, each 3 hours, extracting liquid filtering was concentrated into thick paste, and drying under reduced pressure is ground into fine powder, makes powder.
Embodiment 9:
Radix Astragali 150g, Radix Codonopsis 75g, Radix Angelicae Sinensis 75g, date 175g, prepared rhizome of rehmannia 55g, PORPHYRIN IRON 45g
Take by weighing the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, date, the prepared rhizome of rehmannia of described weight proportion, add 8 times of amount 70% alcohol extracts 3 times, each 1.5 hours, extract merges, and filters, and decompression recycling ethanol is to thick paste, drying under reduced pressure is ground into fine powder, adds PORPHYRIN IRON, mixing adds sucrose, aspartame, and dextrin is an amount of, mixing is with 85% alcohol granulation, drying, whole grain namely gets granule.
Embodiment 10:
Radix Astragali 10g, Radix Codonopsis 200g, Radix Angelicae Sinensis 10g, date 300g, prepared rhizome of rehmannia 10g, ferrous lactate 100g
Take by weighing the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, date, the prepared rhizome of rehmannia of described weight proportion, add 12 times of amount 50% alcohol extracts 2 times, each 2 hours, extract merges, and filters, and decompression recycling ethanol is to thick paste, drying under reduced pressure is ground into fine powder, adds ferrous lactate, mixing adds lactose, sweet mellow wine is an amount of, mixing, with 85% alcohol granulation, drying, whole grain namely gets granule.
Embodiment 11:
Radix Astragali 300g, Radix Codonopsis 10g, Radix Angelicae Sinensis 200g, date 50g, prepared rhizome of rehmannia 150g, ferrous fumarate 10g
Take by weighing the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, date, the prepared rhizome of rehmannia of described weight proportion, add 6 times of amount 95% alcohol extracts 4 times, each 1 hour, extract merged, filter, decompression recycling ethanol is to thick paste, drying under reduced pressure, be ground into fine powder, add ferrous fumarate, mixing, it is an amount of to add sodium carboxymethyl starch, superfine silica gel powder, microcrystalline cellulose, PVPP, and mixing is granulated, drying adds dolomol, mixing, compressing tablet, dressing or dressing not namely get tablet.
Embodiment 12:
Radix Astragali 100g, Radix Codonopsis 100g, Radix Angelicae Sinensis 50g, date 200g, prepared rhizome of rehmannia 30g, ironic citrate 30g
Take by weighing the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, date, the prepared rhizome of rehmannia of described weight proportion, add 7 times of amount 60% alcohol extracts 1 time, each 3 hours, extracting liquid filtering, decompression recycling ethanol be to thick paste, drying under reduced pressure, be ground into fine powder, add ironic citrate, mixing, add appropriate amount of auxiliary materials, mixing is granulated drying, encapsulated, namely get capsule.
Embodiment 13:
Radix Astragali 200g, Radix Codonopsis 50g, Radix Angelicae Sinensis 100g, date 150g, prepared rhizome of rehmannia 80g, Ferric Sodium Edetate 60g
Take by weighing the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, date, the prepared rhizome of rehmannia of described weight proportion, add 8 times of water gagings and extract 3 times, each 2 hours, extracting liquid filtering, be concentrated into thick paste, drying under reduced pressure is ground into fine powder, adds Ferric Sodium Edetate, mixing adds right amount of auxiliary materials, and mixing is made pill.
Embodiment 14:
Radix Astragali 280g, Radix Codonopsis 20g, Radix Angelicae Sinensis 180g, date 60g, prepared rhizome of rehmannia 140g, PORPHYRIN IRON 50g
Take by weighing the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, date, the prepared rhizome of rehmannia of described weight proportion, add 8 times of amount 60% alcohol extracts 3 times, each 2 hours, extracting liquid filtering, Recycled ethanol is to without the alcohol flavor, and is suitably concentrated, add PORPHYRIN IRON, stir evenly, add an amount of supensoid agent, flavor enhancement, anticorrisive agent, mixing, add the water constant volume, filter, packing namely gets oral liquid.
Further set forth the beneficial effect of composition of the present invention by following experiment:
1, test material
Combination group 1 of the present invention, 2 is prepared by embodiment 1,9 respectively; Placebo.
2, test apparatus, reagent and test environment requirement
Electrocardiogram, B ultrasonic scanner, blood counting instrument, sphygmomanometer, RF-540 fluophotometer, ACS180 Full-automatic chemiluminescence immunoassay analysis meter.
3, test method
Adopt two kinds of experimental design of contrast between self and group.To meet inclusive criteria and guarantee the trial volunteer of compatibility test, be divided at random test-meal group 1, test-meal group 2, control group, consider as far as possible the principal element such as age, the economic situation etc. that affect the result, carry out the harmony check, with the comparativity between the assurance group.Took continuously 60 days, and carried out the test-meal test by blind method.Duration of test does not change original eating habit, normal diet.
4, result of the test
(1) crowd gave tested material after 60 days, and the content of hemoglobin variation sees Table 1.Test first three groups crowd's content of hemoglobin is without significant difference (P＞0.05), and test group 1,2 hemoglobins raise to some extent after the test, before and after self and with the control group comparing difference conspicuousness (P＜0.05) is arranged all.
The variation of hemoglobin before and after table 1 test (g/L,
)
#: compare with control group, difference has conspicuousness, P＜0.05
*: compare with self, difference has conspicuousness, P＜0.05.
(2) crowd gave tested material after 60 days, and free protoporphyrin level sees Table 2 in the red blood cell.Free protoporphyrin concentration is without significant difference (P＞0.05) in test first three groups crowd's the red blood cell, and free protoporphyrin concentration descends in the rear test group 1 of test, 2 red blood cells, and reaching with the control group comparing difference before and after self all has conspicuousness (P＜0.05).
The interior free protoporphyrin level of red blood cell before and after table 2 test (ug/L,
)
#: compare with control group, difference has conspicuousness, P＜0.05
*: compare with self, difference has conspicuousness, P＜0.05.
5, conclusion
Behind the edible present composition, test-meal group 1,2 hemoglobins are compared with control group and before testing, and difference has conspicuousness (P＜0.05); Free protoporphyrin concentration decline level is compared with control group and before testing in test group 1,2 red blood cells, and difference has conspicuousness (P＜0.05).The prompting present composition has the alimentary anemia of improvement function.
Claims (10)
1. one kind has the composition that improves the alimentary anemia function, it is characterized in that, it is to be made by the component of following weight portion: Radix Astragali 1-30 part, Radix Codonopsis 1-20 part, Radix Angelicae Sinensis 1-20 part, date 5-30 part, prepared rhizome of rehmannia 1-15 part.
2. composition according to claim 1 is characterized in that, it is to be made by the component of following weight portion: Radix Astragali 10-20 part, Radix Codonopsis 5-10 part, Radix Angelicae Sinensis 5-10 part, date 15-20 part, prepared rhizome of rehmannia 3-8 part.
3. composition according to claim 1 is characterized in that, contains iron enriched nutrient 1-10 part in the said composition.
4. composition according to claim 2 is characterized in that, contains iron enriched nutrient 3-6 part in the said composition.
5. according to claim 3 or the preparation method of 4 described compositions, it is characterized in that it is like this preparation:
The Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, date, prepared rhizome of rehmannia with described weight proportion, add 6-12 and doubly measure the 50-95% alcohol extract 1-4 time, each 1-3 hour, extract merged, and filtered, decompression recycling ethanol is to thick paste, drying under reduced pressure is ground into fine powder, adds iron enriched nutrient, mixing namely gets the active component of medicine of the present invention.
6. the preparation method of composition according to claim 5 is characterized in that, the medicine activity component that makes add or do not add auxiliary material routinely technique make acceptable preparation on the pharmacy.
7. the preparation method of composition according to claim 6 is characterized in that, described preparation is oral formulations.
8. the preparation of composition according to claim 7 is characterized in that, described oral formulations refers to tablet, granule, capsule, pill, powder, oral liquid.
9. according to claim 3 or 4 described compositions, it is characterized in that iron enriched nutrient refers to one or more in PORPHYRIN IRON, ferrous lactate, ferrous fumarate, ironic citrate, the Ferric Sodium Edetate.
10. the described composition of any one is used for improving in preparation the application of the health food of alimentary anemia according to claim 1-4.
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| CN2012100913398A Pending CN103355655A (en) | 2012-03-30 | 2012-03-30 | Composition with alimentary anemia improving function and preparation method of composition |
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| CN104256580A (en) * | 2014-08-29 | 2015-01-07 | 江苏康缘阳光药业有限公司 | Composition capable of boosting immunity and improving iron-deficiency anemia, preparation method of composition and application in health product preparation |
| CN104397693A (en) * | 2014-11-28 | 2015-03-11 | 哈尔滨墨医生物技术有限公司 | Tablets for improving alimentary anemia and production method thereof |
| CN104397812A (en) * | 2014-11-28 | 2015-03-11 | 哈尔滨墨医生物技术有限公司 | Compound oral liquid for improving alimentary anemia and production method thereof |
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| CN110367521A (en) * | 2019-07-11 | 2019-10-25 | 深圳市麦金利实业有限公司 | A kind of improvement alimentary anemia health food and preparation method thereof |
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| CN104256580A (en) * | 2014-08-29 | 2015-01-07 | 江苏康缘阳光药业有限公司 | Composition capable of boosting immunity and improving iron-deficiency anemia, preparation method of composition and application in health product preparation |
| AU2015324103B2 (en) * | 2014-09-29 | 2020-05-21 | Fred Hutchinson Cancer Center | Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers |
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| CN112057470A (en) * | 2014-09-29 | 2020-12-11 | 弗莱德哈钦森癌症研究中心 | Compositions, kits and methods for inducing acquired cell resistance using stress protein inducers |
| CN104397693A (en) * | 2014-11-28 | 2015-03-11 | 哈尔滨墨医生物技术有限公司 | Tablets for improving alimentary anemia and production method thereof |
| CN104397812A (en) * | 2014-11-28 | 2015-03-11 | 哈尔滨墨医生物技术有限公司 | Compound oral liquid for improving alimentary anemia and production method thereof |
| CN104872757A (en) * | 2015-05-19 | 2015-09-02 | 云南知味园食品有限公司 | Qi and blood invigorating beverage and processing method thereof |
| CN110367521A (en) * | 2019-07-11 | 2019-10-25 | 深圳市麦金利实业有限公司 | A kind of improvement alimentary anemia health food and preparation method thereof |
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