CN103446525A - Traditional Chinese medicine composition for treating skin diseases as well as preparation method and application of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating skin diseases as well as preparation method and application of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating skin diseases as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition for treating skin diseases is prepared from the following raw materials in parts by weight: 5-15 parts of radix paeoniae rubra, 5-15 parts of rhizoma curcumae, 5-25 parts of rhizoma smilacis glabrae and 5-25 parts of glabrous sarcandra herbs. The traditional Chinese medicine composition for treating skin diseases is based on the dialectical theory of traditional Chinese medicine and is capable of treating both manifestation and root causes and relieving symptoms within a short period, remarkable in effect, free of toxic or side effect after being used for a long term and better in curative effect in clinical application.
Description
Technical field
The present invention relates to a kind of dermopathic Chinese medicine composition for the treatment of, be specifically related to a kind of psoriasis Chinese medicine composition and its preparation method and application for the treatment of.
Background technology
Dermatosis, as psoriasis (Psoriasis) is commonly called as psoriasis, be a kind of common chronic, recurrent and with Ia disease.Clinical manifestation is on wellability erythema basis, coating multilamellar silvery white phosphorus bits.Although different from other diseases is, about 80% patient only has the pruritus symptom, because the skin lesion outward appearance is indecency, causes the psoriatic to experience serious mental pressure, feels oneself inferior, and loses, and suicidal tendency even, affected patient's life quality greatly.Modern medicine thinks that the reason of primary disease is the function of immune system obstacle, generally application of its treatment (for oral administration or external) immunosuppressant, and 17-hydroxy-11-dehydrocorticosterone or the coal tar wet goods medicine that can improve the skin lesion symptom, as anthraline, its salts, tazarotene, skin lesion hemostasis 17-hydroxy-11-dehydrocorticosterone or enlightening silver strip for oral administration, the method such as retinoid, antineoplastic agent, although short-term relief of symptoms effect still can, but prolonged application all has serious toxic and side effects, clinical good effect, the little medicine of side effect of still lacking.
Summary of the invention
The purpose of this invention is to provide a kind of dermopathic Chinese medicine composition and its preparation method and application for the treatment of, the above-mentioned defect existed to overcome prior art.
Treatment of the present invention dermopathic Chinese medicine composition, for the raw material that adopts following weight portion is prepared into:
5～15 parts of Radix Paeoniae Rubra, 5～15 parts of Rhizoma Curcumae, 5～25 parts of Rhizoma Smilacis Glabraes, 5～25 parts of Herba Sarcandraes;
Preferably, be to adopt the raw material of following weight portion to be prepared into:
7～12 parts of Radix Paeoniae Rubra, 7～12 parts of Rhizoma Curcumae, 10～20 parts of Rhizoma Smilacis Glabraes, 10～20 parts of Herba Sarcandraes;
Further preferred, be to adopt the raw material of following weight portion to be prepared into:
8～10 parts of Radix Paeoniae Rubra, 8～10 parts of Rhizoma Curcumae, 14～16 parts of Rhizoma Smilacis Glabraes, 14～16 parts of Herba Sarcandraes;
Most preferred, be to adopt the raw material of following weight portion to be prepared into:
9 parts of Radix Paeoniae Rubra, 9 parts of Rhizoma Curcumae, 15 parts of Rhizoma Smilacis Glabraes, 15 parts of Herba Sarcandraes;
The invention still further relates to a kind of pharmaceutical composition, comprise the above-mentioned Chinese medicine composition for the treatment of effective dose and pharmaceutically acceptable carrier, described carrier refers to the carrier of pharmaceutical field routine, such as: diluent, excipient are as water etc.; Binding agent is as cellulose derivative, gelatin, polyvinylpyrrolidone etc.; Filler is as starch etc.; Burst apart agent as calcium carbonate, sodium bicarbonate; In addition, can also in compositions, add other adjuvant as flavouring agent and sweeting agent.
When oral, it can be prepared into to conventional solid preparation as tablet, powder or capsule etc.;
One of preparation method of the present invention, comprise the steps:
Above-mentioned each medical material is pulverized and mixed respectively, crosses 90～12 mesh sieves, then directly reinstall capsule, or mix and incapsulate or be compressed to tablet with pharmaceutically acceptable carrier;
Two of preparation method of the present invention, comprise the steps:
Above-mentioned raw material of Chinese medicine is ground into to 10～30 purpose coarse powder, add again at the alcohol reflux temperature that 8～12 times of volumetric concentrations are 65～95% and extract 1～9 hour, preferably extract 2～3 times, each 0.5～3 hour, extracting solution is condensed into dry extract, and after pulverizing, preparation becomes solid dosage forms, or extracting solution is condensed into to the extractum that Baume degrees is 1.2～1.4, then mix with pharmaceutically acceptable carrier, be prepared into various solid dosage formss;
Three of preparation method of the present invention, comprise the steps:
By above-mentioned raw material of Chinese medicine, add under the water reflux temperature of 8-15 times of weight and extract 1～9 hour, preferably extract 2～3 times, each 0.5～3 hour, extracting solution is concentrated into 1mL containing 1.5～2.5 gram medical materials, and adding ethanol to pure volumetric concentration is 65～75%, and precipitation is spent the night, filter, filtrate decompression is concentrated, removes ethanol, is condensed into thick paste or dried cream powder or spray drying and obtains extract powder, mix with pharmaceutically acceptable carrier again, prepare various solid preparations;
Four of preparation method of the present invention, comprise the steps:
By above-mentioned raw material of Chinese medicine, add under the water reflux temperature of 8-15 times of weight and extract 1～9 hour, preferably extract 2～3 times, each 0.5～3 hour, extracting solution is concentrated into 1mL containing 1.5～2.5 gram medical materials, and adding ethanol to pure volumetric concentration is 65～75%, and precipitation is spent the night, filter, filtrate decompression is concentrated, removes ethanol, is condensed into the extractum that Baume degrees is 1.15-1.4, then mix with pharmaceutically acceptable external carrier, be prepared into external preparation.
The inventor thinks, psoriatic is because groups of people are not anti-because of body constitution, innate deficiency, and the evil human body of invading of poison, gather the skin space between skin and muscles, and cause coagulation of QI-blood, and battalion defends and becomes estranged, and meridians block, and malicious heresy is accumulate for a long time, sends out skin outward and forms dermatosis; Psoriasis is impaired with internal organs, and vim and vigour are become estranged, the Wei Buchang of battalion, many pathological factors such as pathogen usually intruding into collateral in protracted disease, cause eventually evil poison and hold back Fu Jibiao, fresh blood is difficult to supplement nutrition, and ecchymosis is difficult to lead off, while therefore treating, with the noxious dryness stasis of blood, sets forth one's views, with blood enriching and dryness moistening, removing pathogenic heat from blood and toxic substance from the body is main, and assistant is with the product of disperse blood stasis and dredge collateral.According to this principle, the inventor, in a large amount of tests, has preferably obtained above-mentioned prescription.
In prescription:
The Radix Paeoniae Rubra clearing away heat and cooling blood, recover nutrient blood and circulate without hindrance; Rhizoma Curcumae removing blood stasis eliminating stagnation, Herba Sarcandrae Rhizoma Smilacis Glabrae removing toxic substances and promoting subsidence of swelling, adjust the immunity of organism metabolism, and all medicines share, and play altogether blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, dredging the meridian, flourish effect of supporting skin.
Animal experiment proves, the dermopathic Chinese medicine composition for the treatment of of the present invention has good curative effect for the treatment psoriasis, can be used for the treatment of psoriasis.
Can put on the patient who needs treatment by oral, external approach, dosage is generally: oral 40～50/ body weight skies specifically can, according to age of patient, the state of an illness etc., be determined by the doctor;
Animal experiment proves, the dermopathic Chinese medicine composition for the treatment of of the present invention, and toxicity is less, even life-time service does not have toxic and side effects yet.
The dermopathic Chinese medicine composition for the treatment of of the present invention, adopt tcm theory, this double controlling of table, but relief of symptoms in a short time, and remarkably productive, prolonged application, do not have toxic and side effects, and clinical practice has curative effect preferably.
The specific embodiment
Embodiment 1
The preparation of tablet:
Take raw materials of traditional Chinese medicinal materials according to following deal:
9 parts of Radix Paeoniae Rubra, 9 parts of Rhizoma Curcumae, 15 parts of Rhizoma Smilacis Glabraes, 15 parts of Herba Sarcandraes;
Above-mentioned pulverizing medicinal materials is become to 20 purpose coarse powder, take 10 times of bulking value concentration as twice of 70% ethanol extraction backflow, each 2 hours, merge extractive liquid,, extracting solution is condensed into the extractum that Baume degrees is 1.3, and the starch that adds described extractum weight 50%% mixes, granulate, drying, add the magnesium stearate mix homogeneously of described extractum weight 3%, beats sheet and obtain tablet.
Embodiment 2
The preparation of capsule:
Take raw materials of traditional Chinese medicinal materials according to following deal:
10 parts of Radix Paeoniae Rubra, 8 parts of Rhizoma Curcumae, 16 parts of Rhizoma Smilacis Glabraes, 16 parts of Herba Sarcandraes;
Above-mentioned medical material is dried, and is ground into 100 purpose fine powders, adds fine powder weight 3% magnesium stearate, enters capsule and gets final product.
Embodiment 3
The preparation of pill
Take raw materials of traditional Chinese medicinal materials according to following deal:
8 parts of Radix Paeoniae Rubra, 10 parts of Rhizoma Curcumae, 14 parts of Rhizoma Smilacis Glabraes, 16 parts of Herba Sarcandraes;
The water reflux temperature that above-mentioned medical material is added to 10 times of weight extracts, and extraction time is 1.5 hours, and extracting solution is concentrated into 1mL containing 2 gram medical materials, and adding ethanol to pure volumetric concentration is 70%, and precipitation is spent the night, and filters the thick extractum of filtrate decompression simmer down to; Drying, water is general is ball, coating gets final product.
Embodiment 4
The preparation of oral liquid:
9 parts of Radix Paeoniae Rubra, 10 parts of Rhizoma Curcumae, Rhizoma Smilacis Glabrae 14,15 parts of Herba Sarcandraes;
Above-mentioned medical material adds the water reflux, extract, 0.5 hour of 12 times of weight, and extracting solution is concentrated into 1mL containing 2 gram medical materials, and adding ethanol to pure volumetric concentration is 70%, precipitation is spent the night, and filters, and filtrate decompression is concentrated, remove ethanol, filter, add the tween 80 of filtrate weight 3% in filtrate, the sodium benzoate of the benzoic acid of filtrate weight 0.05%, filtrate weight 0.05%, mix, packing, the wet-hot steam sterilizing, obtain oral liquid.
Embodiment 5
The preparation of externally-applied liniment:
9 parts of Radix Paeoniae Rubra, 9 parts of Rhizoma Curcumae, 15 parts of Rhizoma Smilacis Glabraes, 15 parts of Herba Sarcandraes;
Above-mentioned pulverizing medicinal materials is become to 10 order coarse powder, twice of the alcohol reflux that the 10 times of weight amount volumetric concentrations of take are 70%, each 3 hours, merge extractive liquid,, being evaporated to containing pure weight is 3%, obtain concentrated solution, add the Borneolum Syntheticum of concentrated solution weight 1%, the sodium benzoate of concentrated solution weight 0.1%, obtain liniment; Or add the Borneolum Syntheticum of concentrated solution weight 1%, the polyvinyl alcohol of concentrated solution weight 20%, obtain liniment.
Embodiment 6
It is test model that the present embodiment adopts Mus tail scale, and medicine of the present invention is tested.
Psoriatic's skin structure and mouse tail skin approach, and are therefore the common model of estimating the psoriasis curative effect.Drugs compared is the disclosed compositions of listing medicine enlightening silver strip.
1.1 laboratory animal
60 of Kunming mouses, male 30, female 30.Body weight 20 ~ 25g.Adopt the grouping of table of random number method, in male and female separately in colony, by body weight, mice is divided into to 3 groups, in every group, Mouse Weight is identical or close, each group is that the male and female number is identical, 3 groups that generate are respectively the normal saline matched groups, the medicine group of the embodiment of the present invention 1, positive drug enlightening silver strip group;
1.2 administration and dosage
The normal saline matched group gives isometric distilled water, and medicine group administration 20g/kg(dosage of the present invention is the medical material amount), positive drug administration 0.13g/kg, the administration volume is 0.2ml/10g;
1.3 experimental procedure
Use the irrigation stomach device gastric infusion, once a day, the continuous gavage of mice 15 days, during medication, weigh at interval of 2 days, to adjust dosage, 1h after the last day gavage, mice is put to death in the cervical vertebra dislocation, gets mice Mus back range root 1.8cm place skin one rectangular, is stored in 10% methanol normal saline fixative.The conventional organization section, HE dyeing, observe under light microscopic, and a scale has the granular layer cells of embarking on journey continuously to be judged to be the scale that granular layer forms, and counts the scale number that granular layer is arranged in continuous 100 scales.Adopt SPSS software, carry out date processing and statistics, measurement data adopt number all ± standard deviation means, relatively adopt one factor analysis of variance between group, relatively adopt in twos least significant difference check, non-just too or heterogeneity of variance, adopt rank test, and set P<0.05 for thering is statistical significance.
Experimental result sees the following form:
The impact of medicine of the present invention on mice Mus tail scale
From result of the test, with matched group, to compare, enlightening silver strip group and of the present invention group of medicine all can significantly promote the formation of Mus tail scale granular layer, have compared utmost point significant difference with matched group, medicine of the present invention is better than commercially available enlightening silver strip.
Embodiment 7
It is test model that the present embodiment adopts female mice vaginal basal cell, and medicine of the present invention is tested.The epidermal differentiation of female Mus vagina epithelium under diethylstilbestrol stimulates is too fast, have silk minute columns increases and differentiation is incomplete phenomenon and psoriasis epidermis excessively differentiation and the incomplete characteristics of differentiation identical, therefore female Mus vagina epithelium experiment be also psoriasis commonly use pathological model it
1 laboratory animal
80 of Kunming mouses, female, by the table of random number method, assign in 3 groups, respectively: normal saline group, the medicine group of the embodiment of the present invention 1, positive drug enlightening silver strip group;
2 dosages
The normal saline matched group gives isometric distilled water, medicine group administration 20g/kg of the present invention, and positive drug group administration 0.13g/kg, the administration volume is 0.2ml/10g;
3 experimental procedures
Except the normal saline group, all the other are respectively organized mice and only all annotate diethylstilbestrol 0.2ml/, every day 1 time.Continuous 4 days.Within the 5th day, start gavage, gavage is 7 days continuously, and after the last day gavage 1 hour, injection colchicine 2mg/kg.6h after injection, mice is put to death in the cervical vertebra dislocation, takes off immediately vagina tissue, is stored in 10% formaldehyde normal saline fixative.The conventional organization section, HE dyeing, observe under light microscopic, counts the mitosis number in every 100 basal cells.
4 experimental datas see the following form
Medicine of the present invention is on the mitotic impact of mouse vagina epithelium
From result of the test, compare model group mouse vagina epithelium significantly increases with matched group, and the modeling success is described; Of the present invention group and positive drug group compare with model group that all there were significant differences, illustrate that the silk that extremely has that medicine of the present invention and enlightening silver strip all can significantly suppress the mouse vagina epithelium separates.
The test of the medicine of other embodiments of the invention, result is similar.
Embodiment 8
Anxious poison experiment
Laboratory animal: Kunming mouse, female 12, male 13, body weight 18 ~ 22g;
The alcohol extract 2.53g/ml of medicine: embodiment 1
Experimental procedure:
1. the mice adaptability is fed 3～4 days, and body weight control is in 22g
2. before the mice administration, water 12h is can't help in fasting;
3. grouping, be assigned to mice in blank group and administration group by the table of random number method, and 12 every group, male and female half and half.
4. administration, blank group gives normal saline, and the administration group gives four flavor side's alcohol extracts.Gavage amount 0.25ml/10g.
One day twice.Administration for the first time is equivalent to 79 times of people's clinical dosage, is superposed to 158 times for twice.
Experimental result: after gavage, mice is movable to be reduced, and loss of appetite, after 24 hours, is recovered gradually.After 48 hours, fully normal.Feed 1 week continuously, not abnormal the appearance.General mortality rate 0.According to the experience of Chinese medicine studies on acute toxicity, can think that this patent medicine is safe.
Claims (7)
1. treat dermopathic Chinese medicine composition, it is characterized in that, for the raw material that adopts following weight portion is prepared into: 5～15 parts of Radix Paeoniae Rubra, 5～15 parts of Rhizoma Curcumae, 5～25 parts of Rhizoma Smilacis Glabraes, 5～25 parts of Herba Sarcandraes.
2. the dermopathic Chinese medicine composition for the treatment of according to claim 1, is characterized in that, is to adopt the raw material of following weight portion to be prepared into: 7～12 parts of Radix Paeoniae Rubra, 7～12 parts of Rhizoma Curcumae, 10～20 parts of Rhizoma Smilacis Glabraes, 10～20 parts of Herba Sarcandraes.
3. the dermopathic Chinese medicine composition for the treatment of according to claim 1, is characterized in that, is to adopt the raw material of following weight portion to be prepared into: 8～10 parts of Radix Paeoniae Rubra, 8～10 parts of Rhizoma Curcumae, 14～16 parts of Rhizoma Smilacis Glabraes, 14～16 parts of Herba Sarcandraes.
4. the dermopathic Chinese medicine composition for the treatment of according to claim 1, is characterized in that, is to adopt the raw material of following weight portion to be prepared into: 9 parts of Radix Paeoniae Rubra, 9 parts of Rhizoma Curcumae, 15 parts of Rhizoma Smilacis Glabraes, 15 parts of Herba Sarcandraes.
5. a pharmaceutical composition, is characterized in that, comprises the described Chinese medicine composition of claim 1～4 any one and the pharmaceutically acceptable carrier for the treatment of effective dose.
6. according to the dermopathic Chinese medicine composition preparation method of the described treatment of claim 1～4 any one, it is characterized in that, comprise the steps:
Above-mentioned each medical material is pulverized and mixed respectively, crosses 90～12 mesh sieves, then directly reinstall capsule, or mix and incapsulate or be compressed to tablet with pharmaceutically acceptable carrier;
Perhaps comprise the steps:
Above-mentioned raw material of Chinese medicine is ground into to 10～30 purpose coarse powder, add again at the alcohol reflux temperature that 8～12 times of volumetric concentrations are 65～95% and extract 1～9 hour, extract 2～3 times, each 0.5～3 hour, extracting solution is condensed into dry extract, and after pulverizing, preparation becomes solid dosage forms, or extracting solution is condensed into to the extractum that Baume degrees is 1.2～1.4, then mix with pharmaceutically acceptable carrier, be prepared into various solid dosage formss;
Perhaps comprise the steps:
By above-mentioned raw material of Chinese medicine, add under the water reflux temperature of 8-15 times of weight and extract 1～9 hour, extract 2～3 times, each 0.5～3 hour, extracting solution is concentrated into 1mL containing 1.5～2.5 gram medical materials, and adding ethanol to pure volumetric concentration is 65～75%, and precipitation is spent the night, filter, filtrate decompression is concentrated, removes ethanol, is condensed into thick paste or dried cream powder or spray drying and obtains extract powder, mix with pharmaceutically acceptable carrier again, prepare various solid preparations;
Perhaps comprise the steps:
By above-mentioned raw material of Chinese medicine, add under the water reflux temperature of 8-15 times of weight and extract 1～9 hour, extract 2～3 times, each 0.5～3 hour, extracting solution is concentrated into 1mL containing 1.5～2.5 gram medical materials, and adding ethanol to pure volumetric concentration is 65～75%, and precipitation is spent the night, filter, filtrate decompression is concentrated, removes ethanol, is condensed into the extractum that Baume degrees is 1.15-1.4, then mix with pharmaceutically acceptable external carrier, be prepared into external preparation.
7. the application of the described Chinese medicine composition of claim 1～4 any one in preparation treatment psoriasis.
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