CN102949681A

CN102949681A - Composition for preventing or treating colds, and its preparation method

Info

Publication number: CN102949681A
Application number: CN2011102413734A
Authority: CN
Inventors: 王凯乾; 富力; 鲁岐; 王典仁; 惠敏; 刘国友; 吴艳萍; 程一伦; 王旭; 于伟厚; 王海玲
Original assignee: 富力
Priority date: 2011-08-22
Filing date: 2011-08-22
Publication date: 2013-03-06
Anticipated expiration: 2031-08-22
Also published as: CN102949681B

Abstract

The invention relates to a medicinal composition for preventing or treating colds, and its preparation method. The composition is prepared through using ginseng, jujube, dry ginger, wild chrysanthemum flower, tea leaves, Lycium Chinense, longan, Radix Astragali, licorice and brown sugar according to a certain weight ratio. The traditional Chinese medicinal composition can be processed to prepare any common oral dosage forms and healthcare products, has the cold prevention and treatment efficacies, has the effects of qi tonifying, blood enriching, liver and kidney nourishing, spleen invigorating, stomach warming, blood stasis dispersing and pain relieving, and can well prevent and treat the colds in the daily application. The medicinal composition has the advantages of obvious effect, taking convenience, good mouthfeel, and no toxic side effects.

Description

The composition and method of making the same of a kind of prevention or treatment flu

Technical field

The present invention relates to the composition and method of making the same of a kind of prevention and treatment flu, particularly a kind of plant-derived prevention and the composition and method of making the same for the treatment of flu belong to food, health product and medicine field.

Background technology

In worldwide, flu is comparatively common disease, and Coritab is one of the most used, that consumption is maximum medicine.

The medicine that Western medicine is used for the treatment of flu or influenza is mainly antiallergic agent, alleviates medicine and antipyretic analgesic three classes of nasal mucosa hyperemia.The antiallergic agent that relatively is usually used in anti-flu is chlorphenamine and loratadine etc.The now widely used medicine that alleviates nasal mucosa hyperemia is pseudoephedrine, and it has the effect that selectivity shrinks nasal mucosa vessels.Antipyretic analgesic as anti-flu usefulness is mainly aspirin, ibuprofen, diclofenac and acetaminophen etc.Western medicine is for alleviating cold symptoms successful, rapid.But Western medicine also exists many untoward reaction and toxic and side effects.Be Coritab commonly used such as SUXIAO GANMAO JIAONANG, long-term taking can produce dependency and hepatic and renal function injure.Bibliographical information, severe patient can bring out the pathological changes such as hepatic necrosis, analgesic interstitial nephritis, acute papillary necrosis, cause at last hepatic and kidney function obstacle, are developed to hepatic necrosis, liver cirrhosis, hepatocarcinoma and uremia etc.The Coritab compound recipes such as acetyl aminophenol, diclofenac sodium, aspirin all may cause the digestive system untoward reaction, and main manifestations is nauseating, vomiting, stomachache etc., and digestive tract hemorrhage, liver function injury can appear in small number of patients.In addition, also can cause hematological, main manifestations is granulocytopenia, thrombocytopenic purpura, acute aplastic anemia.Somedon still contains aminophenazone and Phenacetin except containing caffeine.According to statistics, existing many cases are taken the medicine source incidents that somedon causes death.

Health product and the Chinese medicine preparation of in the market various preventions and treatment flu, the deficiency such as have that production cost is too high and raw material supply is unsettled, control of product quality is difficult, slow curative effect or curative effect are not obvious.The present invention then provides a kind of easy to use, cheap, health product and Chinese medicine preparation of prevention and treatment flu being had obvious curative effects.

Summary of the invention

Main purpose of the present invention is for the prior art of the health product of above-mentioned prevention and treatment flu and Chinese medicine preparation and the problem that product exists, and provides a kind of for prevention and treatment flu composition and method of making the same.Present composition prescription is simple, uses the medical material of integration of edible and medicinal herbs to be raw material, has heat-clearing toxin-expelling functions, improves the human body immunity, prevents and treat the obvious effect of flu, has simultaneously the effect of vigorate qi and replenish the blood, enriching yin and nourishing kidney, spleen invigorating warming the stomach, blood-activating analgetic.The preparation method of the present invention's prevention and treatment flu compositions is easy, stable processing technique, cheap and easy to carry and use.

For realizing purpose of the present invention, one aspect of the present invention provides the compositions of a kind of prevention and treatment flu, comprises following crude drug: brown sugar, Fructus Jujubae, Rhizoma Zingiberis, Flos Chrysanthemi Indici.

Wherein, the weight portion proportioning of described crude drug is: brown sugar 0.1～30, Fructus Jujubae 0.05～30, Rhizoma Zingiberis 0.1～20, Flos Chrysanthemi Indici 0.01～10; Be preferably: brown sugar 0.5～20, Fructus Jujubae 0.5～20, Rhizoma Zingiberis 0.5～10, Flos Chrysanthemi Indici 0.05～5; More preferably: brown sugar 10～15, Fructus Jujubae 10～15, Rhizoma Zingiberis 5～9, Flos Chrysanthemi Indici 0.5～5.

Medicine brown sugar of the present invention, Fructus Jujubae, Rhizoma Zingiberis, Flos Chrysanthemi Indici are used in combination, so that each efficacy of drugs produces synergism, thereby can more effectively prevent and treat flu.

Brown sugar possesses outside the function of sugar, and brown sugar also has the effect of vigorate qi and replenish the blood, spleen invigorating warming the stomach, slow middle pain relieving, activating blood circulation to dissipate blood stasis.It contains vitamin and trace element the modern study proof, and is easily digested such as ferrum, zinc, manganese, chromium etc., can regain one's strength of body fast, enhance vigour, so brown sugar is otherwise known as " chocolate in east "; The folic acid that contains in the brown sugar, trace substance etc. can accelerate blood circulation, increase the composition of blood volume, stimulate the hemopoietic function of body, expanding blood volume, nutrition, oxygen, the water supply of raising cell.

Fructus Jujubae has invigorating the spleen and replenishing QI, and the effect of nourishing blood to tranquillize the mind is mainly used in treating insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.Important active substance jujube polysaccharide has obvious complement activity and promotes Proliferation of lymphocytes in the Fructus Jujubae, can improve immunity of organisms; Contain in the Fructus Jujubae with Radix Ginseng in contained dammarane type Saponin roughly the same, have the effect that strengthens human tolerance and resisting fatigue; The soap-like matter that Fructus Jujubae contains has the effects such as balance the body metabolism, enhancing immunity, antiinflammatory, antiallergic action, blood sugar lowering and cholesterol level; The vitamin C that Fructus Jujubae is rich in has very strong antioxidant activity and promotes the effect of collagen protein synthesis, can participate in histiocytic redox reaction, relevant with the metabolism of many kinds of substance in the body, enhancing development, physical strength reinforcing, raising immunity, lessen fatigue.

Rhizoma Zingiberis has warming spleen and stomach for dispelling cold, and recuperating depleted YANG is promoted blood circulation, dampness expectorant, the effect of warming the lung to resolve fluid-retention.Clinical in coldness and pain in the epigastrium, vomiting is had loose bowels, cold extremities faint pulse, the treatment that phlegm retention is breathed with cough.Rhizoma Zingiberis contains 2%～3% volatile oil, and Rhizoma Zingiberis volatile oil is faint yellow or yellowish green oily liquids, and main constituent is zingiberone in the oil, is β-heerabolene, α-curcumene, β-sesquiphellandrene and zingiberol secondly.Get the peppery pure and mild Rhizoma Zingiberis Recens diketone of dehydrogenation Rhizoma Zingiberis Recens and dehydrogenation Rhizoma Zingiberis Recens diketone by fresh ginger, the biosynthesis of prostaglandin is had inhibitory action.Rhizoma Zingiberis contains the peppery ketenes of volume Rhizoma Zingiberis Recens, a small amount of peppery alcohol of Rhizoma Zingiberis Recens, micro-zingiberone.Pharmacological research proves, to mice inject respectively ginger essential oil 0.3mg/kg, dolantin 40mg/kg and etc. capacity tween saline, respectively organize mice after the administration in 30 minutes and only all inject 0.3% acetic acid 0.2ml/, record simultaneously the writhing response number of times of mice in 20 minutes, the result shows the remarkable analgesic activity of ginger essential oil tool; Research shows that also ginger ketenes, gingerol gavage in the Rhizoma Zingiberis have refrigeration function to rat by the heating due to the yeast, and the antipyretic effect timeliness is long.

Flos Chrysanthemi Indici has the effect of heat-clearing and toxic substances removing, dispelling wind suppressing the hyperactive liver.Be used for the treatment of anemopyretic cold, laryngopharynx swelling and pain, conjunctival congestion and swelling pain, have a headache dizzy and furuncle carbuncle disease.Flos Chrysanthemi Indici water extract and volatile oil all have antiviral, antibiotic activity.The Flos Chrysanthemi Indici water extract has stronger inhibitory action to staphylococcus aureus, diphtheria corynebacterium, Bacillus typhi, escherichia coli, Bacillus proteus, dysentery bacterium, escherichia coli, Pseudomonas aeruginosa, Fu Shi he bacterium.Flos Chrysanthemi Indici volatile oil is stronger to the staphylococcus aureus effect, and is effective to Staphylococcus albus.Flos Chrysanthemi Indici water extract and volatile oil have significant antiinflammatory, immunosuppressive action, but volatile oil is better to the inflammation effect due to the chemicals, and water extract is better to the inflammatory effect due to the foreign preteins pro-inflammatory cytokine; By in the Flos Chrysanthemi Indici the chrysanthemol that partly is separated to of lipotropy have obvious antiinflammatory action.The Flos Chrysanthemi Indici decoct has the effect that promotes phagocytic activity of leukocytes, and in vitro tests shows the Flos Chrysanthemi Indici decoct of 1: 1280 concentration, and the effect that promotes that human leukocytes is engulfed staphylococcus aureus is arranged, and also has the effect of resisting pathogenic microbes.

In order to reach better prevention and therapeutic effect, the present composition also makes up with Radix Ginseng, Fructus Lycii, Arillus Longan, the Radix Astragali, Radix Glycyrrhizae, Folium Camelliae sinensis.Have strongly invigorating primordial QI, enriching yin and nourishing kidney, strengthening the body resistance, warming the lung to resolve fluid-retention, vigorate qi and replenish the blood, the effect of spleen invigorating warming the stomach are used in combination, so that the active component in each medical material produces synergism, and collaborative effect of promoting prevention and treatment flu.

The weight portion proportioning of the composition material medicine of the present invention's prevention and treatment flu is: brown sugar 0.1～30, Fructus Jujubae 0.05～30, Rhizoma Zingiberis 0.1～20, Flos Chrysanthemi Indici 0.01～10, Radix Ginseng 0.01～1, Fructus Lycii 0.05～5, Arillus Longan 0.01～10, the Radix Astragali 0.01～5, Radix Glycyrrhizae 0.01～10, Folium Camelliae sinensis 0.1～1; Be preferably: brown sugar 0.5～20, Fructus Jujubae 0.5～20, Rhizoma Zingiberis 0.5～10, Flos Chrysanthemi Indici 0.05～5, Radix Ginseng 0.1～0.5, Fructus Lycii 0.1～2.5, Arillus Longan 0.1～5, the Radix Astragali 0.1～3, Radix Glycyrrhizae 0.1～5, Folium Camelliae sinensis 0.1～0.5; More preferably: brown sugar 10～15, Fructus Jujubae 10～15, Rhizoma Zingiberis 5～9, Flos Chrysanthemi Indici 0.5～5, Radix Ginseng 0.2～0.4, Fructus Lycii 0.5～2.5, Arillus Longan 1～5, the Radix Astragali 0.5～2, Radix Glycyrrhizae 1～4, Folium Camelliae sinensis 0.2～0.3.

Wherein, Folium Camelliae sinensis is chosen as green tea, yellow tea, Ramulus et Folium Mussaendae Pubescentis, postfermented tea, black tea or Folium Camelliae sinensis.

Radix Ginseng is the Araliaceae herbaceos perennial, and the ancient pharmacy ancient books and records Shennong's Herbal about Chinese medicine of China is classified Radix Ginseng as top grade, says its " main tonifying five ZANG-organs, peace spirit decide soul, and spasmolytic is throbbed with fear, and make eye bright, happy Fructus Alpiniae Oxyphyllae, taking for a long time has the effect of making light of one's life by commiting suicide and prolonging life ".The main composition of Radix Ginseng is ginsenoside (Ginsenoside), and modern pharmacological research proves that it has the effects such as the immunity of raising, strengthening by means of tonics, blood circulation promoting and blood stasis dispelling, resisting fatigue.

Fructus Lycii has nourishing the liver and kidney, replenishing vital essence to improve eyesight.Be used for the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, the not clear grade of blurred vision disease.The mature fruit of Fructus Lycii contains betanin, atropine, hyoscyamine.Contain again the Semen Maydis xanthin, physalin, kryptoxanthin, scopoletin, carotene, thiamine, riboflavin, nicotinic acid, vitamin C, seed contain several amino acids and inorganic elements; The polysaccharide that also contains the effect of tool Promote immunity, content are 7.09%.Contain again the sp act aminoacid such as taurine, γ-aminobutyric acid.The Fructus Lycii decoct has obvious antifatigue effect.

Arillus Longan has spleen reinforcing stomach reinforcing, nourishing blood to tranquillize the mind effect.Be used for weakness of the spleen and stomach, inappetence, or insufficiency of vital energy and blood, body void is weak; Heart spleen blood deficiency, insomnia forgetfulness, palpitation with fear is uneasy.Arillus Longan contains the multiple nutrients material, and blood-enriching tranquillizing is arranged, nourishing the brain and improving intelligence, the effect of tonic heart spleen.Arillus Longan contains glucose, sucrose and the various nutrients such as vitamin A, B, and wherein containing more is albumen, fat and several mineral materials.These nutrients all are very essential to human body.For the people who works with one's mind, consume sad temper blood especially, more effective; Arillus Longan can be treated after being ill weak or mental deterioration.

The Radix Astragali has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent.Be used for the treatment of that the deficiency of vital energy is weak, spontaneous perspiration, blood deficiency and yellow complexion, interior-heat is quenched one's thirst etc.The invigorating middle warmer of Radix Astragali Preparata QI invigorating is given birth to consolidating superficial resistance holder skin ulcer.The Radix Astragali contains various trace elements.The Radix Astragali can significantly increase the total white blood cells in the blood, promotes phagocytic function and the sterilizing ability of neutrophilic granulocyte and macrophage.The Astragalus membranaceus gastric infusion can obviously strengthen the activity of natural killer cells in mice, and this process and inducement interferon occur simultaneously.Astragalus polysaccharides also can stimulate the propagation of NK cell, and makes cyton become large.The Radix Astragali mainly is to produce the 7-interferon by induction of lymphocyte to mediate to the facilitation of NK cytoactive, and the Radix Astragali parallels with the antiviral activity that it is induced the facilitation of NK cytoactive.The Radix Astragali is cultivated with the mouse spleen cell external, also can induce gamma interferon.Mice with spleen deficiency Astragalus membranaceus and astragalus polysaccharides to Radix Et Rhizoma Rhei causes after the administration, all can recover the ability that its spleen produces IL-2.The Radix Astragali also can strengthen peripheral blood lymphocyte to the reactivity of IL-2, makes peripheral blood lymphocyte be subjected to IL-2 to stimulate rear its proliferation index to increase.The Radix Astragali can strengthen the muscular strength of rat and mice; Strengthen the fatigue proof effect of rats'swimming, and the stress rats plasma cortisol increases obviously, it strengthens rat anti-stress ability and realizes by the adrenal cortex reinforcing function.

Radix Glycyrrhizae has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.The root of Radix Glycyrrhizae and rhizome master contain glycyrrhizin and multiple triterpenoid saponin, flavone, coumarin, neolignan etc., also contain multiple polysaccharide with immunological stimulation.Liquorice flavonoids compound has inhibitory action to staphylococcus aureus, bacillus subtilis, yeast, fungus, streptococcus etc.; Glycyrrhizin to the human immunity defective virus (HIV (human immunodeficiency virus) (Human Immunodeficiency Virus), HIV), hepatitis virus, vesicle oral cavity virus, adenovirus III type, herpes simplex virus I-type, vaccinia virus etc. all have obvious inhibitory action; Radix Glycyrrhizae has 17-hydroxy-11-dehydrocorticosterone sample antiinflammatory action, to mice chemical auricle edema, abdominal cavity capillary permeability increase, rat granuloma is swollen, formaldehyde rat paw edema, chondrus ocellatus Holmes colloidality rat arthritis etc. have inhibitory action; The administration of monoammonium glycyrrhizinate salt pair guinea pig intraperitoneal injection can obviously suppress the generation of guinea pig bronchial asthma, shows as to draw the time of breathing heavily and obviously prolong.Can cover on the pharyngeal mucosa of inflammation after the including of Radix Glycyrrhizae extractum sheet mouth, relax inflammation to its stimulation, reach antitussive effect.Radix Glycyrrhizae can also make expectorant be easy to expectoration by promoting the secretion of throat and bronchial mucosa, presents the eliminating phlegm and relieving cough effect.Enoxolone, licoflavone, Radix Glycyrrhizae fluidextract gastric infusion, the mouse cough that ammonia and sulfur dioxide are caused all has antitussive effect, and phlegm-dispelling functions is all arranged.Enoxolone choline salt subcutaneous injection sucks the cough that ammonia and electricity irritation cat superior laryngeal nerve cause to Cavia porcellus, and obvious antitussive effect is all arranged.

The basis of Folium Camelliae sinensis has: (1) catechin: being commonly called as tea tannin, is the peculiar composition of Folium Camelliae sinensis, has hardship, astringent taste and convergence; (2) caffeine: with bitterness, be the important composition that consists of the millet paste flavour; (3) mineral: contain 11 kinds of mineral such as abundant potassium, calcium, magnesium, manganese in the tea.Catechin is commonly called as tea tannin, is the peculiar composition of Folium Camelliae sinensis, can be combined with caffeine in millet paste and relaxes the physiological action of Caffeine On Human body.The effects such as tool antioxidation, anti-halmatogenesis, antitumor, reduction Blood Cholesterol and low low-density ester gp content, inhibition increased blood pressure, inhibition platelet aggregation, antibiotic, anti-product allergy.Distinctive catechin and oxidative condensation thing thereof can make in the tea excitation of caffeine slow down and continue in the tea, therefore the people that can make long-distance driving of having tea keeps clearheaded and has legs.Contain abundant mineral in the tea, the millet paste Positive Ion Content is more and anion is less, belongs to basic food, can help body fluid to keep alkalescence, keeps fit.

The present invention improves the preparation method of the combination of a kind of prevention and treatment flu on the other hand, comprises following in sequence step:

1) prepare crude drug according to following weight portion proportioning:

Brown sugar 0.1～30, Fructus Jujubae 0.05～30, Rhizoma Zingiberis 0.1～20, Flos Chrysanthemi Indici 0.01～10;

2) Fructus Jujubae, Flos Chrysanthemi Indici are mixed and made into the crude drug mixture after, add the water mix homogeneously after, carry out heating extraction 2-3 time, merge extractive liquid, makes the first extracting solution;

3) collect Rhizoma Zingiberis volatile oil with the hydrodistillation method after Rhizoma Zingiberis is mixed with water for subsequent use, carry out concentration after the aqueous extract of Rhizoma Zingiberis and the merging of the first extracting solution, make mixing extractum;

4) Rhizoma Zingiberis volatile oil is added in the aqueous solution of enclose material, carries out enclose and process, make the Rhizoma Zingiberis volatile oil clathrate;

5) extractum carries out adding brown sugar and Rhizoma Zingiberis volatile oil clathrate after the dried, mix homogeneously, and get final product.

The weight portion proportion optimization of crude drug wherein, step 1) is: brown sugar 0.5～20, Fructus Jujubae 0.5～20, Rhizoma Zingiberis 0.5～10, Flos Chrysanthemi Indici 0.05～5; More preferably: brown sugar 10～15, Fructus Jujubae 10～15, Rhizoma Zingiberis 5～9, Flos Chrysanthemi Indici 0.5～5.

Wherein, the weight of crude drug mixture described in each heating extraction process is 1: 6～12 with the ratio of the weight of the water of adding step 2).

Particularly, the heating extraction temperature is 60～100 ℃, is preferably 80～100 ℃; The heating extraction time is 1～4h/ time, is preferably 1～3h/ time; The weight of described crude drug mixture is preferably 1: 9 with the ratio of the weight of the water of adding～and 12.

Particularly, after the crude drug mixture adds the water mix homogeneously, soak 20～90min, carry out again described heating extraction.

Especially, described soak time is preferably 30～60min, more preferably 30min.

Wherein, step 3) the weight portion proportioning of Rhizoma Zingiberis and water is 1: 6～12 described in, be preferably 1: 10～and 12; The temperature of described concentration is 60～100 ℃, is preferably 90～100 ℃; The relative density of described extractum is 11～1.7, is preferably 1.1～1.3.

Particularly, adopt volatile oil extractor to collect Rhizoma Zingiberis volatile oil.

Especially, Rhizoma Zingiberis and water are placed volatile oil extractor, heating is carried out steam distillation and is extracted volatile oil, until after the amount of the Rhizoma Zingiberis volatile oil in the volatile oil extractor no longer increased, stopped heating was collected Rhizoma Zingiberis volatile oil from volatile oil extractor.

Particularly, described concentration is that the heating evaporation under normal pressure is processed, and is under the 1atm in absolute pressure namely, and aqueous extract and the first extracting solution of the Rhizoma Zingiberis after heating merges make moisture evaporation wherein, reach concentrated purpose.

Wherein, enclose step 4) is processed and is comprised the steps:

4-A) with Rhizoma Zingiberis volatile oil and organic solvent mixing, make volatile oil solution;

4-B) volatile oil solution joins in the aqueous solution of enclose material, stirs, and carries out enclose and processes, and makes the volatile oil clathrate compound mixed liquor;

4-C) with the volatile oil clathrate compound mixed liquor under 4 ℃, leave standstill place 12～72h after, filter oven dry, and get final product.

Particularly, step 4-A) organic solvent is selected one or more in methanol, dehydrated alcohol, chloroform, ethyl acetate, acetonitrile, the dichloromethane described in, is preferably dehydrated alcohol.

Particularly, the weight of Rhizoma Zingiberis volatile oil step 4-A) is 0.1～20: 100 with the ratio of the volume of dehydrated alcohol, be preferably 1～10: 100, more preferably 1～6: 100, be the Rhizoma Zingiberis volatile oil that mixes 0.1～20g in the dehydrated alcohol of every 100ml, perhaps mix the Rhizoma Zingiberis volatile oil of 0.1～20kg in the dehydrated alcohol of 100L.

Particularly, the enclose material step 4-B) is selected cyclodextrin or cyclodextrin derivative.

Especially, described cyclodextrin derivative selective polymerization cyclodextrin nano microgranule, polymeric cyclodextrins, branched cyclodextrin, 2,6-DM-β-CD, glucose-beta-schardinger dextrin-, nanometer group-beta-cyclodextrin, sulfobutyl ether beta-schardinger dextrin-, methyl-beta-schardinger dextrin-, random methylated-beta-schardinger dextrin-, HP-β-CD, 2-HP-BETA-CD, 3-HP-β-CD, 2,3-dihydroxypropyl-beta-schardinger dextrin-, 2, a kind of in 3,6-, three HP-β-CD or the hydroxyethyl-β-cyclodextrin.

Especially, described cyclodextrin is selected alpha-cyclodextrin, beta-schardinger dextrin-or gamma-cyclodextrin, is preferably beta-schardinger dextrin-.

Wherein, the mass percent concentration of the aqueous solution of described enclose material water solution beta-schardinger dextrin-is 3～5%; Temperature is 30～100 ℃, is preferably 60～70 ℃.

Particularly, the ratio of the weight of the beta-schardinger dextrin-in the aqueous solution of Rhizoma Zingiberis volatile oil and beta-schardinger dextrin-is 1: 10～20, be preferably 1: 13～and 20.

Particularly, step 4-B) enclose processing time 1～4h described in is preferably 2～3h; The enclose temperature is 30～100 ℃, is preferably 60～70 ℃.

Particularly, at step 4-B) in described volatile oil solution is added drop-wise in the aqueous solution of enclose material, stir, carry out enclose and process, make the volatile oil clathrate compound mixed liquor;

Especially, rate of addition is 0.1～10ml/min, is preferably 1～6ml/min.

Particularly, leave standstill step 4-C) and be preferably 24～48h standing time; Described bake out temperature is 35～45 ℃, is preferably 40 ℃; Drying time is 6～48h, is preferably 12～48h.

Wherein, step 5) temperature of dried is 50～80 ℃ described in, is preferably 50～70 ℃; Be 48～96h drying time; Extractum moisture content after the dried is 2～6%.

Particularly, also comprise and mixing with brown sugar and Rhizoma Zingiberis volatile oil clathrate again after dried extract powder is broken into 50～100 order extract powders.

Further aspect of the present invention provides the preparation method of the combination of a kind of prevention and treatment flu, comprises following in sequence step:

1) prepare crude drug according to following weight portion proportioning:

Brown sugar 0.1～30, Fructus Jujubae 0.05～30, Rhizoma Zingiberis 0.1～20, Flos Chrysanthemi Indici 0.01～10, Radix Ginseng 0.01～1, Fructus Lycii 0.05～5, Arillus Longan 0.01～10, the Radix Astragali 0.01～5, Radix Glycyrrhizae 0.01～10, Folium Camelliae sinensis 0.1～1;

2) Fructus Jujubae, Flos Chrysanthemi Indici, Radix Ginseng, Fructus Lycii, Arillus Longan, the Radix Astragali, Radix Glycyrrhizae, Folium Camelliae sinensis are mixed and made into the crude drug mixture after, add the water mix homogeneously after, carry out heating extraction 2～3 times, merge extractive liquid, makes the first extracting solution;

The weight portion proportion optimization of crude drug wherein, step 1) is: brown sugar 0.5～20, Fructus Jujubae 0.5～20, Rhizoma Zingiberis 0.5～10, Flos Chrysanthemi Indici 0.05～5, Radix Ginseng 0.1～0.5, Fructus Lycii 0.1～2.5, Arillus Longan 0.1～5, the Radix Astragali 0.1～3, Radix Glycyrrhizae 0.1～5, Folium Camelliae sinensis 0.1～0.5; More preferably: brown sugar 10～15, Fructus Jujubae 10～15, Rhizoma Zingiberis 5～9, Flos Chrysanthemi Indici 0.5～5, Radix Ginseng 0.2～0.4, Fructus Lycii 0.5～2.5, Arillus Longan 1～5, the Radix Astragali 0.5～2, Radix Glycyrrhizae 1～4, Folium Camelliae sinensis 0.2～0.3.

Wherein, Folium Camelliae sinensis step 1) is green tea, black tea or Folium Camelliae sinensis; Step 2) weight of crude drug mixture described in each heating extraction process is 1: 6～12 with the ratio of the weight of the water of adding in.

Particularly, after the crude drug mixture adds the water mix homogeneously, soaked 20～90 minutes, carry out again described heating extraction.

Particularly, described concentration is that the heating evaporation under normal pressure is processed, and namely under 1atm, aqueous extract and the first extracting solution of the Rhizoma Zingiberis after heating merges make moisture evaporation wherein, reach concentrated purpose.

Wherein, enclose step 4) is processed and is comprised the steps:

4-B) volatile oil solution joins in the aqueous solution of enclose material, stirs enclose, makes the volatile oil clathrate compound mixed liquor;

Particularly, step 4-B) stirs enclose processing time 1～4h described in, be preferably 2～3h; The enclose treatment temperature is 30～100 ℃, is preferably 60～70 ℃.

Especially, rate of addition is 0.1～10ml/min, is preferably 1～6ml/min.

Particularly, leave standstill step 4-C) and be preferably 24～36h standing time; Described bake out temperature is 35～45 ℃, is preferably 40 ℃; Drying time is 6～48h, is preferably 20～48h.

Wherein, step 5) dried described in temperature be 50～80 ℃, be preferably 50～70 ℃; Be 48～96h drying time; Extractum moisture content after the dried is 2～6%.

Another aspect of the invention provides the pharmaceutical preparation of the treatment flu that acceptable auxiliary material combination is made on a kind of compositions by above-mentioned arbitrary described prevention and treatment flu and the pharmaceutics.

Wherein, prevention of the present invention and treatment flu compositions can be made clinical acceptable peroral dosage form by tradition or modern production technique with acceptable adjuvant on the pharmaceutics.Such as powder, medicinal tea, granule, capsule, tablet, concentrated pill, drop pill, membrane, soft extract, oral liquid or oral breast etc.Used excipient substance can be starch, dextrin, lactose, microcrystalline cellulose, gelatin, sucrose, magnesium stearate, erythritol, xylitol, Sorbitol, mannitol, maltose alcohol, hydroxyl isomaltulose, hydrogenated starch hydrolysate, stevioside, steviolbioside, dihydrochalcone, glycyrrhizin, xylitol, aspartame, alitame, glucide, cyclamate, acesulfame-K, sucralose etc.Need clinically long-term prescription, make solid preparation and store conveniently, the patient takes facility, also meeting the market requirement more.Preferred dosage form is capsule, granule, tablet.

The present invention's prevention and treatment flu compositions have following advantage:

1, the present invention's prevention and treatment flu compositions prescription compatibility science, determined curative effect, safe, quality controllable;

2, the present invention's prevention and treatment flu compositions have the effect of heat-clearing and toxic substances removing, warming spleen and stomach for dispelling cold, warming the lung to resolve fluid-retention, can prepare prevention and treatment flu, active component in each medical material produces synergism, and has the effect of vigorate qi and replenish the blood, spleen invigorating warming the stomach, slow middle pain relieving, activating blood circulation to dissipate blood stasis;

3, the present invention prevention and treatment flu combination of Chinese medicine material are that the Chinese crude drug of integration of edible and medicinal herbs can long-term taking, have no side effect the prevention of preparation and treatment cold medicine or health product successful;

4, the preparation method of the present invention's prevention and treatment flu compositions is simple, and process conditions are gentle, low cost of manufacture.

The specific embodiment

Further describe the beneficial effect of medicine of the present invention below by the specific embodiment, these test examples have comprised the pharmacodynamics test of medicine Kangganmao Granule I of the present invention (embodiment 2), Kangganmao Granule II (embodiment 6), anti-influenza tablet I (embodiment 1), anti-influenza tablet II (embodiment 5).These embodiment only are exemplary, scope of the present invention are not consisted of any restriction.It will be understood by those skilled in the art that and do not departing under prescription thinking of the present invention, the purposes scope and can make amendment or replace the details of technical solution of the present invention and form, but these modifications and replacing all fall within the scope of protection of the present invention.

The refrigeration function of test example 1 Kangganmao Granule

1, test material:

Japan large ear rabbit: male and female half and half, body weight 1.8～2.0kg is provided by dimension tonneau China zoopery center, quality certification numbering SCXK (capital) 2009-001.

Kangganmao Granule I (embodiment 2): 10g/ bag (every bag contains crude drug 17g); Kangganmao Granule II (embodiment 6): 10g/ bag (every bag contains crude drug 20g);

Positive drug: aspirin tablet (Shijiazhuang Shineway Pharmaceutical Co., Ltd, 0.3g/ sheet, lot number 20080103);

Escherichia coli endotoxin (Shanghai biological factory).

2, test method:

48 health large ear rabbits are divided into 6 groups at random, every group 8, be model control group (equal-volume normal saline), aspirin positive drug matched group (0.1g/kg), Kangganmao Granule I high dose group (10g/kg) and low dose group 5g/kg), Kangganmao Granule II high dose group (10g/kg) and low dose group (5g/kg), every group every day gavage 1 time, 2h after the 3rd day gavage, large ear rabbit is placed on the fixed mount, insert anal 5cm with digital thermometer, every 20min measures 1 body temperature after white rabbit is stable, continuous measurement 3 times, its average is between 38.90～39.16 ℃, as basal body temperature.Then behind white rabbit auricular vein Escherichia Coli Injection endotoxin 10 μ g/kg, measured 1 body temperature in 1,2,3,4,5,6 hour, observe body temperature and change.Temperature taking the results are shown in Table 1.

Table 1 Kangganmao Granule to escherichia coli endotoxin cause heating inhibitory action

Table 1 result of the test shows, compositions Kangganmao Granule of the present invention can obviously suppress the fervescence that caused by bacterial endotoxin, high dose group and aspirin have similar action, compare with model control group, have significant difference (P＜0.01), and its refrigeration function can be kept more than the 6h; Low dose group has significant hypothermal effect (P＜0.01) in pyrogenicity 2～4h, after this separate thermal effect and weaken gradually (P＜0.05);

Test example 2 Kangganmao Granule extracorporeal bacteria inhibitor tests

1, test material:

Strain: staphylococcus aureus [CMCC (B) 26003] (Nat'l Pharmaceutical ﹠ Biological Products Control Institute).

Positive drug: penicillin-V potassium sheet (is revised Tonghua City pharmaceutical Co. Ltd of Pharmaceutical group; 0.25g/ sheet; Lot number: 20090817); Cold drug sheet (Tianshili Pharmaceutic Co., Ltd., Jiangsu; 0.25g/ sheet; Lot number: 20090106).

2, test method:

Take by weighing each 6g of Kangganmao Granule I, II, add respectively pH 7.0 aseptic sodium chloride-peptone buffer agent 30ml jolting, mixing makes 0.2g/ml test liquid I, II; Get 1 of penicillin-V potassium sheet, grind, with pH 7.0 aseptic sodium chloride-peptone buffer agent dissolving and be diluted to the 0.000025g/ml solution of (being equivalent to penicillin V 42.375U/ml), contrast liquid I as positive drug; Get cold drug sheet 3g, add pH 7.0 aseptic sodium chloride-peptone buffer agent 15ml jolting, mixing is the positive control solution II of 0.2g/ml.

Get 6 in aseptic empty test tube, put into Kangganmao Granule test liquid I (0.2g/ml) in the 1st test tube, 2-6 props up and adds respectively 5ml pH 7.0 aseptic sodium chloride-peptone buffer agents in the test tube, in the 1st test tube, take out 5ml and put into the 2nd test tube, mixing, be the test liquid I of 0.1g/ml, take out 5ml with method from the 2nd test tube and put into the 3rd test tube, 6 test tubes of serial dilution to the like this, the concentration that contains of test solution I is followed successively by: 0.2,0.1,0.05,0.025,0.0125,0.00625g/ml; Get 12 in aseptic empty test tube, be divided into 2 groups, according to the method described above test liquid II, cold drug sheet solution (being positive control solution II) gradient dilution are become to contain the solution that concentration is followed successively by 0.2,0.1,0.05,0.025,0.0125,0.00625g/ml.

Preparation nutrient agar (peptone 10g, Carnis Bovis seu Bubali cream 3g, sodium chloride 5g, agar 15g, distilled water 1000mL), heating for dissolving, adjusting pH is 7.4, is sub-packed in the glass container, through 121 ℃ of sterilization 20min, is stored in dark cold place for subsequent use.Above-mentioned test liquid, each 1mL of positive control solution of getting respectively variable concentrations add heating for dissolving, and in 45～50 ℃ of water-baths in the nutrient agar of balance, and shaking by swirling plate immediately, making the abundant mixing of sample and culture medium, drawing respectively concentration after the band culture medium solidifying is 5 * 10 again ⁵The staphylococcus aureus suspension of CFU/ml (approximately 1～2 μ l) is inoculated in the agar plate surface that contains mentioned solution, hatches 24h, observed result for 36 ± 1 ℃.

In nutrient agar, adding the aseptic sodium chloride of pH7.0-peptone buffer agent 1ml, and do not inoculate the staphylococcus aureus suspension and contrast as diluent; To add the aseptic sodium chloride of pH7.0-peptone buffer agent 1ml, still inoculate the staphylococcus aureus suspension and contrast as positive bacteria.Result of the test sees Table 2.

Table 2 Plating extracorporeal bacteria inhibitor test result

+: the long bacterium of expression test ware;-: the not long bacterium of expression test ware; /: the expression test is not done.

Result of the test shows: potassium v calcium is extremely sensitive to staphylococcus aureus [CMCC (B) 26003]; And the cold drug sheet is not obvious to the bacteriostasis of golden Portugal bacterium; Anti-flu compositions of the present invention is inhibited to staphylococcus aureus, and solid Plating minimum inhibitory concentration is 0.1g/ml.

The inhibitory action of 3 pairs of rat Granuloma formations of test example

1, test material:

Rat: male, body weight 166 ± 18g is provided by dimension tonneau China zoopery center, quality certification numbering SCXK (capital) 2009-001.

Positive drug: dexamethasone sodium phosphate injection (Community in Baiyunshan, Guangzhou pharmaceutical factory, specification: 1ml:1mg; Lot number: 20090314).

2, test method:

Get 28 of the male white rats of body weight 166 ± 18g, be divided at random 4 groups, 7 every group, i.e. blank group, Kangganmao Granule I group, Kangganmao Granule II group and positive drug matched group.Under etherization, routine disinfection is implanted the aseptic cotton balls of heavy 30.0 ± 0.1mg in oxter, the rat left and right sides respectively, and next day after the operation, blank group rat gavage gives normal saline 30ml/kg; Kangganmao Granule I group rat gastric infusion Kangganmao Granule I 1g/kg; Kangganmao Granule II group rat gastric infusion Kangganmao Granule II 1g/kg; Positive drug matched group rat intramuscular injection 0.5% dexamethasone sodium phosphate 2ml/kg, once a day, after continuous 7 days, put to death animal, take out cotton balls, put in the dry weighing botle, precision weighing after under 60 ℃ dry 12 hours calculates every group of granulomatous weight, and measurement result sees Table 3.

Table 3 Kangganmao Granule is to granulomatous inhibitory action

Annotate: ^*P＜0.02, ^*P＜0.001

Result of the test shows: Kangganmao Granule can significantly suppress granulomatous growth, has significant difference (P＜0.02), illustrates that the compositions of prevention of the present invention and treatment flu has antiinflammatory action.

Test example 4 paratartaric acid antimony potassium cause the impact of mouse writhing

1, experiment material:

Kunming mice: male and female half and half, body weight 20 ± 5g provides quality certification numbering: SCXK (capital) 2009-003 by dimension tonneau China zoopery center.

Positive drug: morphine hydrochloride injection (Shenyang No. 1 Pharmaceutical Factory, specification: 0.5ml:5mg; Lot number: 20090602).

2, test method:

Get body weight 20 ± 5g, 36 of the kunming mices of male and female half and half are divided into 4 groups at random, and 9 every group, namely blank group, Kangganmao Granule I group, Kangganmao Granule II organize and the positive drug group.Blank group kunming mice gavage gives the equal-volume normal saline, Kangganmao Granule I group kunming mice gastric infusion Kangganmao Granule I 2g/kg; Kangganmao Granule II group kunming mice gastric infusion Kangganmao Granule II2g/kg, positive drug group kunming mice subcutaneous injection 0.1% morphine hydrochloride 15ml/kg, 1% antimony potassium tartrate 10ml/kg is newly joined in injection after 30 minutes, observe immediately and record each Mus writhing number of times in 10 minutes, cumulative calculation is respectively organized the mouse writhing number of times, the results are shown in Table 4.

Table 4 Kangganmao Granule paratartaric acid antimony potassium causes the impact of mouse writhing

Annotate: ^*P＜0.01, ^*P＜0.001

Result of the test shows: Kangganmao Granule of the present invention can significantly reduce the writhing number of times of mice, illustrates that anti-flu compositions of the present invention has analgesic activity.

The toxic action that may exist body in order to study Chinese medicine composition of the present invention is estimated the drug safety that utilizes this pharmaceutical composition, has carried out acute toxicity test and long term toxicity test.

Test example 5 acute toxicity tests

Choosing NIH is 40 of healthy mices, and body weight is the 18-20 gram, is divided at random two groups of anti-influenza tablet I (embodiment 1) group, anti-influenza tablet II (embodiment 5) groups, 20 every group, and male and female half and half.First fasting 12 hours before the experiment, during experiment, with the dose of the tolerant Cmax of white mice, maximum volume, anti-influenza tablet I, II are mixed with suspension with distilled water respectively, according to 30g/kg body weight gastric infusion 1 time, observe 7 days.Experimental result is not measured Chinese medicine composition of the present invention to mice LD50 value, this dosage is equivalent to 150 times of clinical dosage, medicine of the present invention greater than 30g/kg, shows medicine of the present invention or functional food without acute toxic reaction to the maximum tolerated dose of mice lavage administration, and safety is good.

Test example 6 long term toxicity tests

After animal feeding observed for 1 week, selecting the normal NIH of indices is 168 of healthy mices, be divided at random 7 groups, be model control group (equal-volume starch suspension), anti-influenza tablet I (embodiment 1) high dose group (4g/kg), dosage group (2g/kg) among the anti-influenza tablet I, anti-influenza tablet I low dose group (1g/kg), anti-influenza tablet II (embodiment 5) high dose group (4g/kg), dosage group (2g/kg) among the anti-influenza tablet II, anti-influenza tablet II low dose group (1g/kg), during off-test, randomly draw 20 for every group and measure indices, residue is put to death and is cutd open inspection.

Basic, normal, high dosage group dosage is equivalent to 5 times, 10 times, 20 times of quantity.Anti-influenza tablet I, II are mixed with suspension with distilled water respectively, every day 2 per os gastric infusions, matched group gives the starch suspension of equivalent, 12 weeks of successive administration.Detect index, and be aided with the pathological examination that animal is respectively organized internal organs, the toxicity situation of overall merit medicine with general performance, body weight, hematology and Biochemical Indices In Serum before and after the animals administer, routine urinalysis, organ weights equipotential.

The result shows: drug particles of the present invention changes without the significance difference opposite sex the weight of animals, and animal growth is normal; Every Index for examination of high, medium and low dosage treated animal shows no obvious abnormalities; The result of histopathologic examination demonstration, three dosage treated animals are respectively organized the internal organs no abnormality seen.Show that medicine of the present invention has no the long term toxicity reaction, is safe medication.

Come by the following examples further to set forth the preparation method of medicine of the present invention.

The preparation of embodiment 1 anti-influenza tablet of the present invention

1) according to following weight proportion prepare raw material (* 100g):

Brown sugar 10, Fructus Jujubae 15, Rhizoma Zingiberis 7.5, Flos Chrysanthemi Indici 2

2) with behind Fructus Jujubae, the Flos Chrysanthemi Indici mix homogeneously, place in the Multifunctional Chinese medicine extraction pot, add tap water and soak 60min, the weight of the tap water that wherein adds is 9: 1 with the ratio of Fructus Jujubae, Flos Chrysanthemi Indici gross weight;

3) open the multi-function extractor power supply and heat, be heated to 100 ℃, remain on constant temperature extraction filtration after 1 hour under this temperature, obtain for the first time extracting solution; In filtering residue, divide the adding tap waters 2 times, heating extraction 2 times, the temperature of each heating extraction is 100 ℃, and the weight of the tap water of adding is 9: 1 with the ratio of Fructus Jujubae, Flos Chrysanthemi Indici gross weight, and extraction time is 1 hour, filters to obtain extracting solution 2 times; Merge 3 times extracting solution, obtain the first extracting solution;

4) Rhizoma Zingiberis and water are placed volatile oil extractor, wherein Rhizoma Zingiberis is 1: 12 with the ratio of the weight of the water of adding, then be heated to 100 ℃, carry out steam distillation and extract volatile oil, until after the amount of the Rhizoma Zingiberis volatile oil in the volatile oil extractor no longer increased, stopped heating was collected Rhizoma Zingiberis volatile oil from volatile oil extractor, Rhizoma Zingiberis after extracting is filtered, obtain the Rhizoma Zingiberis extracting solution;

5) Rhizoma Zingiberis volatile oil is joined in the dehydrated alcohol, after mixed dissolution becomes volatile oil solution, volatile oil solution splashes into temperature in the aqueous solution of 70 ℃, the mass percent concentration beta-schardinger dextrin-as 5% take the speed of 1ml/min, stirring, enclose, make Rhizoma Zingiberis volatile oil clathrate mixed liquor, wherein, the weight of Rhizoma Zingiberis volatile oil is 3: 100 with the ratio of the volume of dehydrated alcohol, namely adds the 3g Rhizoma Zingiberis volatile oil in every 100ml dehydrated alcohol; The mass ratio of the beta-schardinger dextrin-in Rhizoma Zingiberis volatile oil and the beta-schardinger dextrin-solution is 1: 15;

6) after volatile oil solution adds, be under 70 ℃ of conditions keeping temperature, stirring, enclose were processed 2 hours, then the volatile oil clathrate compound mixed liquor was placed 24 hours under 4 ℃ of conditions, the clathrate Precipitation filters, filtering residue obtains the Rhizoma Zingiberis volatile oil clathrate in 40 ℃ of oven dry 36h;

7) Rhizoma Zingiberis extracting solution and the first extracting solution are merged, heat under normal pressure, carry out evaporation and concentration and process, obtain relative density and be 11 extractum, wherein, thickening temperature is 90 ℃;

8) extractum is placed 50 ℃ of lower dry 72h, cross 80 mesh sieves after pulverizing, get the dry extract powder;

9) with behind dry extract, brown powdered sugar, the Rhizoma Zingiberis volatile oil clathrate mix homogeneously, add supplementary product starch, alcohol granulation, drying, granulation, and dry, be pressed into anti-influenza tablet.

The preparation of embodiment 2 Kangganmao Granules of the present invention

1) according to following weight proportion prepare raw material (* 100g):

Brown sugar 10, Fructus Jujubae 10, Rhizoma Zingiberis 5, Flos Chrysanthemi Indici 1

2) with behind Fructus Jujubae, the Flos Chrysanthemi Indici mix homogeneously, place in the Multifunctional Chinese medicine extraction pot, add tap water and soak 45min, the weight of the tap water that wherein adds is 10: 1 with the ratio of Fructus Jujubae, Flos Chrysanthemi Indici gross weight;

3) open the multi-function extractor power supply and heat, be heated to 80 ℃, remain on constant temperature extraction filtration after 2.5 hours under this temperature, obtain for the first time extracting solution; In filtering residue, divide the adding tap waters 2 times, heating extraction 2 times, the temperature of each heating extraction is 80 ℃, and the weight of the tap water of adding is 10: 1 with the ratio of Fructus Jujubae, Flos Chrysanthemi Indici gross weight, and extraction time is 2.5 hours, filters to obtain extracting solution 2 times; Merge 3 times extracting solution, obtain the first extracting solution;

4) Rhizoma Zingiberis and water are placed volatile oil extractor, wherein Rhizoma Zingiberis is 1: 10 with the ratio of the weight of the water of adding, then be heated to 100 ℃, carry out steam distillation and extract volatile oil, until after the amount of the Rhizoma Zingiberis volatile oil in the volatile oil extractor no longer increased, stopped heating was collected Rhizoma Zingiberis volatile oil from volatile oil extractor, Rhizoma Zingiberis behind the extraction volatile oil is filtered, obtain the Rhizoma Zingiberis extracting solution;

5) Rhizoma Zingiberis volatile oil is joined in the dehydrated alcohol, after mixed dissolution becomes volatile oil solution, volatile oil solution is added drop-wise to temperature in the aqueous solution of 60 ℃, the mass percent concentration beta-schardinger dextrin-as 4% take the speed of 3ml/min, stirring, enclose, make Rhizoma Zingiberis volatile oil clathrate mixed liquor, wherein, the weight of Rhizoma Zingiberis volatile oil is 6: 100 with the ratio of the volume of dehydrated alcohol, namely adds the 6g Rhizoma Zingiberis volatile oil in every 100ml dehydrated alcohol; The mass ratio of the beta-schardinger dextrin-in Rhizoma Zingiberis volatile oil and the beta-schardinger dextrin-solution is 1: 20;

6) after volatile oil solution adds, be under 60 ℃ of conditions keeping temperature, stirring, enclose were processed after 2 hours, the volatile oil clathrate compound mixed liquor was placed 24 hours under 4 ℃ of conditions, and the clathrate Precipitation filters, filtering residue obtains the Rhizoma Zingiberis volatile oil clathrate in 40 ℃ of oven dry 36h;

7) Rhizoma Zingiberis extracting solution and the first extracting solution are merged, heat under normal pressure, carry out evaporation and concentration and process, obtain relative density and be 1.3 extractum, wherein, thickening temperature is 100 ℃;

8) extractum is placed 65 ℃ of lower dry 48h, cross 80 mesh sieves after pulverizing, get the dry extract powder;

9) with behind dry extract, brown powdered sugar, the Rhizoma Zingiberis volatile oil clathrate mix homogeneously, add microcrystalline cellulose excipients, alcohol granulation, drying namely makes Kangganmao Granule.

The preparation of embodiment 3 capsulae anticoryzaes of the present invention

1) according to following weight proportion prepare raw material (* 100g):

Brown sugar 15, Fructus Jujubae 12, Rhizoma Zingiberis 7, Flos Chrysanthemi Indici 2.2

2) with behind Fructus Jujubae, the Flos Chrysanthemi Indici mix homogeneously, place in the Multifunctional Chinese medicine extraction pot, add tap water and soak 30min, the weight of the tap water that wherein adds is 11: 1 with the ratio of Fructus Jujubae, Flos Chrysanthemi Indici gross weight;

3) open the multi-function extractor power supply and heat, be heated to 100 ℃, remain on constant temperature extraction filtration after 3 hours under this temperature, obtain for the first time extracting solution; Add tap water 1 time in filtering residue, carry out the heating extraction second time, the temperature of extraction is 100 ℃, and the weight of the tap water of adding is 11: 1 with the ratio of Fructus Jujubae, Flos Chrysanthemi Indici gross weight, and extraction time is 3 hours, filters and obtains extracting solution the 2nd time; Merge 2 times extracting solution, obtain the first extracting solution;

4) Rhizoma Zingiberis and water are placed volatile oil extractor, wherein Rhizoma Zingiberis is 1: 12 with the ratio of the weight of the water of adding, then be heated to 100 ℃, carry out steam distillation and extract volatile oil, until after the amount of the Rhizoma Zingiberis volatile oil in the volatile oil extractor no longer increased, stopped heating was collected Rhizoma Zingiberis volatile oil from volatile oil extractor, Rhizoma Zingiberis behind the extraction volatile oil is filtered, obtain the Rhizoma Zingiberis extracting solution;

5) Rhizoma Zingiberis volatile oil is joined in the dehydrated alcohol, after mixed dissolution becomes volatile oil solution, volatile oil solution splashes into temperature in the aqueous solution of 60 ℃, the mass percent concentration beta-schardinger dextrin-as 3.5% take the speed of 2ml/min, stirring, enclose, make Rhizoma Zingiberis volatile oil clathrate mixed liquor, wherein, the weight of Rhizoma Zingiberis volatile oil is 3: 100 with the ratio of the volume of dehydrated alcohol, namely adds the 3g Rhizoma Zingiberis volatile oil in every 100ml dehydrated alcohol; The mass ratio of the beta-schardinger dextrin-in Rhizoma Zingiberis volatile oil and the beta-schardinger dextrin-solution is 1: 13;

6) after volatile oil solution adds, be under 60 ℃ of conditions keeping temperature, stirring, enclose were processed 3 hours, then the volatile oil clathrate compound mixed liquor was placed 36 hours under 4 ℃ of conditions, the clathrate Precipitation filters, filtering residue obtains the Rhizoma Zingiberis volatile oil clathrate in 40 ℃ of oven dry 24h;

7) Rhizoma Zingiberis extracting solution and the first extracting solution are merged, heat under normal pressure, carry out evaporation and concentration and process, obtain relative density and be 115 extractum, wherein, thickening temperature is 90 ℃;

8) extractum was placed 70 ℃ of lower dryings 80 hours, cross 80 mesh sieves after pulverizing, get the dry extract powder;

9) with behind dry extract, brown powdered sugar, the Rhizoma Zingiberis volatile oil clathrate mix homogeneously, add supplementary product starch, alcohol granulation, drying, granulation adds micropowder silica gel, mixing, the hungry area softgel shell of packing into namely gets capsulae anticoryzae.

The preparation of the anti-tea capable of preventing and curing cold of embodiment 4 the present invention

1) according to following weight proportion prepare raw material (* 100g):

Brown sugar 15, Fructus Jujubae 15, Rhizoma Zingiberis 9, Flos Chrysanthemi Indici 3

2) with behind Fructus Jujubae, the Flos Chrysanthemi Indici mix homogeneously, place in the Multifunctional Chinese medicine extraction pot, add tap water and soak 30min, the weight of the tap water that wherein adds is 12: 1 with the ratio of Fructus Jujubae, Flos Chrysanthemi Indici gross weight;

3) open the multi-function extractor power supply and heat, be heated to 100 ℃, remain on constant temperature extraction filtration after 1 hour under this temperature, obtain for the first time extracting solution; In filtering residue, divide the adding tap waters 2 times, heating extraction 2 times, the temperature of each heating extraction is 100 ℃, and the weight of the tap water of adding is 12: 1 with the ratio of Fructus Jujubae, Flos Chrysanthemi Indici gross weight, and extraction time is 1 hour, filters to obtain extracting solution 2 times; Merge 3 times extracting solution, obtain the first extracting solution;

5) Rhizoma Zingiberis volatile oil is joined in the dehydrated alcohol, after mixed dissolution becomes volatile oil solution, volatile oil solution splashes into temperature in the aqueous solution of 65 ℃, the mass percent concentration beta-schardinger dextrin-as 4% take the speed of 5ml/min, stirring, enclose, make Rhizoma Zingiberis volatile oil clathrate mixed liquor, wherein, the weight of Rhizoma Zingiberis volatile oil is 5: 100 with the ratio of the volume of dehydrated alcohol, namely adds the 5g Rhizoma Zingiberis volatile oil in every 100ml dehydrated alcohol; The mass ratio of the beta-schardinger dextrin-in Rhizoma Zingiberis volatile oil and the beta-schardinger dextrin-solution is 1: 18;

6) after volatile oil solution adds, be under 65 ℃ of conditions keeping temperature, stirring, enclose were processed 2 hours, then the volatile oil clathrate compound mixed liquor was placed 24 hours under 4 ℃ of conditions, the clathrate Precipitation filters, filtering residue obtains the Rhizoma Zingiberis volatile oil clathrate in 40 ℃ of oven dry 24h;

8) with extractum in 60 ℃ lower dry 56 hours, cross 80 mesh sieves after pulverizing, get the dry extract powder;

9) with behind dry extract, brown powdered sugar, the Rhizoma Zingiberis volatile oil clathrate mix homogeneously, in the filter paper bag of packing into, make anti-tea capable of preventing and curing cold.

The preparation of embodiment 5 anti-influenza tablets of the present invention

1) according to following weight proportion prepare raw material (* 100g):

Radix Ginseng 0.2, brown sugar 11, Fructus Jujubae 12, Rhizoma Zingiberis 7, Flos Chrysanthemi Indici 0.5, Fructus Lycii 2, Arillus Longan 5, the Radix Astragali 1, Radix Glycyrrhizae 4, Folium Camelliae sinensis 0.2; Wherein, Folium Camelliae sinensis is selected black tea;

2) with behind Fructus Jujubae, Flos Chrysanthemi Indici, Radix Ginseng, Fructus Lycii, Arillus Longan, the Radix Astragali, Radix Glycyrrhizae, the Folium Camelliae sinensis mix homogeneously, place in the Multifunctional Chinese medicine extraction pot, add tap water and soak 60min, the weight of the tap water that wherein adds is 9: 1 with the ratio of Fructus Jujubae, Flos Chrysanthemi Indici, Fructus Lycii, Arillus Longan, the Radix Astragali, Radix Glycyrrhizae, Folium Camelliae sinensis gross weight;

3) open the multi-function extractor power supply and heat, be heated to 100 ℃, remain on that constant temperature extracted 1 hour under this temperature, then filter, obtain for the first time extracting solution; In filtering residue, divide the adding tap waters 2 times, heating extraction 2 times, the temperature of each heating extraction is 100 ℃, the weight of the tap water that adds is 9: 1 with the ratio of Fructus Jujubae, Flos Chrysanthemi Indici, Radix Ginseng, Fructus Lycii, Arillus Longan, the Radix Astragali, Radix Glycyrrhizae, Folium Camelliae sinensis gross weight, extraction time is 1 hour, filters to obtain extracting solution 2 times; Merge 3 times extracting solution, obtain the first extracting solution;

4) Rhizoma Zingiberis and water are placed volatile oil extractor, wherein Rhizoma Zingiberis is 1: 10 with the ratio of the weight of the water of adding, then be heated to 100 ℃, carry out steam distillation and extract volatile oil, until after the amount of the Rhizoma Zingiberis volatile oil in the volatile oil extractor no longer increased, stopped heating was collected Rhizoma Zingiberis volatile oil from volatile oil extractor, Rhizoma Zingiberis after extracting is filtered, obtain the Rhizoma Zingiberis extracting solution;

5) with Rhizoma Zingiberis volatile oil with an amount of anhydrous alcohol solution after, after mixed dissolution becomes volatile oil solution, volatile oil solution splashes into temperature in the aqueous solution of 70 ℃, the mass percent concentration beta-schardinger dextrin-as 5% take the speed of 2ml/min, stirring, enclose, make Rhizoma Zingiberis volatile oil clathrate mixed liquor, wherein, the weight of Rhizoma Zingiberis volatile oil is 5: 100 with the ratio of the volume of dehydrated alcohol, namely adds the 5g Rhizoma Zingiberis volatile oil in every 100ml dehydrated alcohol; The mass ratio of the beta-schardinger dextrin-in Rhizoma Zingiberis volatile oil and the beta-schardinger dextrin-solution is 1: 15;

6) after volatile oil solution adds, be under 70 ℃ of conditions keeping temperature, stirring, enclose were processed 3 hours, then the volatile oil clathrate compound mixed liquor was placed 24 hours under 4 ℃ of conditions, the clathrate Precipitation filters, filtering residue obtains the Rhizoma Zingiberis volatile oil clathrate in 45 ℃ of oven dry 20h;

8) extractum is placed 50 ℃ of lower dry 56h, cross 80 mesh sieves after pulverizing, get the dry extract powder;

The preparation of embodiment 6 Kangganmao Granules of the present invention

1) according to following weight proportion prepare raw material (* 100g):

Radix Ginseng 0.2, brown sugar 13, Fructus Jujubae 11, Rhizoma Zingiberis 7, Flos Chrysanthemi Indici 2, Fructus Lycii 1, Arillus Longan 2, the Radix Astragali 1.5, Radix Glycyrrhizae 2, Folium Camelliae sinensis 0.2; Folium Camelliae sinensis is selected Folium Camelliae sinensis;

2) with behind Fructus Jujubae, Flos Chrysanthemi Indici, Radix Ginseng, Fructus Lycii, Arillus Longan, the Radix Astragali, Radix Glycyrrhizae, the Folium Camelliae sinensis mix homogeneously, place in the Multifunctional Chinese medicine extraction pot, add tap water and soak 45min, the weight of the tap water that wherein adds is 10: 1 with the ratio of Fructus Jujubae, Flos Chrysanthemi Indici, Fructus Lycii, Arillus Longan, the Radix Astragali, Radix Glycyrrhizae, Folium Camelliae sinensis gross weight;

3) open the multi-function extractor power supply and heat, be heated to 80 ℃, remain on constant temperature extraction filtration after 2.5 hours under this temperature, obtain for the first time extracting solution; In filtering residue, divide the adding tap waters 2 times, heating extraction 2 times, the temperature of each heating extraction is 80 ℃, the weight of the tap water that adds is 10: 1 with the ratio of Fructus Jujubae, Flos Chrysanthemi Indici, Radix Ginseng, Fructus Lycii, Arillus Longan, the Radix Astragali, Radix Glycyrrhizae, Folium Camelliae sinensis gross weight, extraction time is 2.5 hours, filters to obtain extracting solution 2 times; Merge 3 times extracting solution, obtain the first extracting solution;

5) volatile oil is joined in the dehydrated alcohol, after mixed dissolution becomes volatile oil solution, volatile oil solution splashes into temperature in the aqueous solution of 60 ℃, the mass percent concentration beta-schardinger dextrin-as 4% take the speed of 1ml/min, stirring, enclose, make Rhizoma Zingiberis volatile oil clathrate mixed liquor, wherein, the weight of Rhizoma Zingiberis volatile oil is 1: 100 with the ratio of the volume of dehydrated alcohol, namely adds the 1g Rhizoma Zingiberis volatile oil in every 100ml dehydrated alcohol; The mass ratio of the beta-schardinger dextrin-in Rhizoma Zingiberis volatile oil and the beta-schardinger dextrin-solution is 1: 20;

6) after volatile oil solution adds, be under 60 ℃ of conditions keeping temperature, stirring, enclose were processed 2 hours, then the volatile oil clathrate compound mixed liquor was placed 24 hours under 4 ℃ of conditions, the clathrate Precipitation filters, filtering residue obtains the Rhizoma Zingiberis volatile oil clathrate in 40 ℃ of oven dry 36h;

8) extractum is placed 65 ℃ of lower dry 72h, cross 80 mesh sieves after pulverizing, get the dry extract powder;

The preparation of embodiment 7 capsulae anticoryzaes of the present invention

1) according to following weight proportion prepare raw material (* 100g):

Radix Ginseng 0.3, brown sugar 14, Fructus Jujubae 10, Rhizoma Zingiberis 9, Flos Chrysanthemi Indici 5, Fructus Lycii 2.5, Arillus Longan 1, the Radix Astragali 0.5, Radix Glycyrrhizae 1, Folium Camelliae sinensis 0.3; Folium Camelliae sinensis is selected green tea;

2) with behind Fructus Jujubae, Flos Chrysanthemi Indici, Radix Ginseng, Fructus Lycii, Arillus Longan, the Radix Astragali, Radix Glycyrrhizae, the Folium Camelliae sinensis mix homogeneously, place in the Multifunctional Chinese medicine extraction pot, add tap water and soak 30min, the weight of the tap water that wherein adds is 11: 1 with the ratio of Fructus Jujubae, Flos Chrysanthemi Indici, Fructus Lycii, Arillus Longan, the Radix Astragali, Radix Glycyrrhizae, Folium Camelliae sinensis gross weight;

3) open the multi-function extractor power supply and heat, be heated to 80 ℃, remain on constant temperature extraction filtration after 3 hours under this temperature, obtain for the first time extracting solution; In filtering residue, divide the adding tap waters 2 times, heating extraction 2 times, the temperature of each heating extraction is 80 ℃, the weight of the tap water that adds is 11: 1 with the ratio of Fructus Jujubae, Flos Chrysanthemi Indici, Radix Ginseng, Fructus Lycii, Arillus Longan, the Radix Astragali, Radix Glycyrrhizae, Folium Camelliae sinensis gross weight, extraction time is 3 hours, filters to obtain extracting solution 2 times; Merge 3 times extracting solution, obtain the first extracting solution;

5) Rhizoma Zingiberis volatile oil is joined in the dehydrated alcohol, after mixed dissolution becomes volatile oil solution, volatile oil solution splashes into temperature in the aqueous solution of 60 ℃, the mass percent concentration beta-schardinger dextrin-as 3.5% take the speed of 6ml/min, stirring, enclose, make Rhizoma Zingiberis volatile oil clathrate mixed liquor, wherein, the weight of Rhizoma Zingiberis volatile oil is 5: 100 with the ratio of the volume of dehydrated alcohol, namely adds the 5g Rhizoma Zingiberis volatile oil in every 100ml dehydrated alcohol; The mass ratio of the beta-schardinger dextrin-in Rhizoma Zingiberis volatile oil and the beta-schardinger dextrin-solution is 1: 13;

6) after volatile oil solution adds, be under 60 ℃ of conditions keeping temperature, stirring, enclose were processed 2 hours, then the volatile oil clathrate compound mixed liquor was placed 36 hours under 4 ℃ of conditions, the clathrate Precipitation filters, filtering residue obtains the Rhizoma Zingiberis volatile oil clathrate in 40 ℃ of oven dry 24h;

8) extractum is placed 70 ℃ of lower dry 68h, cross 80 mesh sieves after pulverizing, get the dry extract powder;

The preparation of the anti-tea capable of preventing and curing cold of embodiment 8 the present invention

1) according to following weight proportion prepare raw material (* 100g):

Radix Ginseng 0.4, brown sugar 10, Fructus Jujubae 15, Rhizoma Zingiberis 5, Flos Chrysanthemi Indici 4, Fructus Lycii 0.5, Arillus Longan 3, the Radix Astragali 2, Radix Glycyrrhizae 3, Folium Camelliae sinensis 0.3; Folium Camelliae sinensis is selected green tea;

2) with behind Fructus Jujubae, Flos Chrysanthemi Indici, Radix Ginseng, Fructus Lycii, Arillus Longan, the Radix Astragali, the Radix Glycyrrhizae mix homogeneously, place in the Multifunctional Chinese medicine extraction pot, add tap water and soak 30min, the weight of the tap water that wherein adds is 12: 1 with the ratio of Fructus Jujubae, Flos Chrysanthemi Indici, Radix Ginseng, Fructus Lycii, Arillus Longan, the Radix Astragali, Radix Glycyrrhizae gross weight;

3) open the multi-function extractor power supply and heat, be heated to 100 ℃, remain on that constant temperature extracted 2 hours under this temperature, then filter, obtain for the first time extracting solution; In filtering residue, add tap water 1 time, carry out the heating extraction second time, the temperature of extraction is 100 ℃, and the weight of the tap water of adding is 12: 1 with the ratio of Fructus Jujubae, Flos Chrysanthemi Indici, Radix Ginseng, Fructus Lycii, Arillus Longan, the Radix Astragali, Radix Glycyrrhizae gross weight, extraction time is 2 hours, filters to obtain extracting solution the 2nd time; Merge 2 times extracting solution, obtain the first extracting solution;

5) Rhizoma Zingiberis volatile oil is joined in the dehydrated alcohol, after mixed dissolution becomes volatile oil solution, volatile oil solution splashes into temperature in the aqueous solution of 65 ℃, the mass percent concentration beta-schardinger dextrin-as 4% take the speed of 4ml/min, stirring, enclose, make Rhizoma Zingiberis volatile oil clathrate mixed liquor, wherein, the weight of Rhizoma Zingiberis volatile oil is 6: 100 with the ratio of the volume of dehydrated alcohol, namely adds the 6g Rhizoma Zingiberis volatile oil in every 100ml dehydrated alcohol; The mass ratio of the beta-schardinger dextrin-in Rhizoma Zingiberis volatile oil and the beta-schardinger dextrin-solution is 1: 18;

6) after volatile oil solution adds, be under 65 ℃ of conditions keeping temperature, stirring, enclose were processed 2 hours, then the volatile oil clathrate compound mixed liquor was placed 24 hours under 4 ℃ of conditions, the clathrate Precipitation filters, filtering residue obtains the Rhizoma Zingiberis volatile oil clathrate in 40 ℃ of oven dry 48h;

8) with extractum in 60 ℃ lower dry 96 hours, cross 80 mesh sieves after pulverizing, get the dry extract powder;

9) with behind dry extract, brown powdered sugar, Folium Camelliae sinensis, the Rhizoma Zingiberis volatile oil clathrate mix homogeneously, in the filter paper bag of packing into, make anti-tea capable of preventing and curing cold.

Claims

1. the compositions of preventing or treating flu is characterized in that comprising following crude drug: brown sugar, Fructus Jujubae, Rhizoma Zingiberis, Flos Chrysanthemi Indici.

2. the compositions of prevention as claimed in claim 1 or treatment flu is characterized in that the weight portion proportioning of described crude drug is: brown sugar 0.1～30, Fructus Jujubae 0.05～30, Rhizoma Zingiberis 0.1～20, Flos Chrysanthemi Indici 0.01～10.

3. the compositions of prevention as claimed in claim 2 or treatment flu is characterized in that the weight portion proportion optimization of described crude drug is: brown sugar 0.5～20, Fructus Jujubae 0.5～20, Rhizoma Zingiberis 0.5～10, Flos Chrysanthemi Indici 0.05～5.

4. the preparation method of a prevention or treatment flu compositions comprises following step of carrying out:

1) prepare crude drug according to following weight portion proportioning:

5. preparation method as claimed in claim 4 is characterized in that the weight portion proportioning of described crude drug is: brown sugar 0.5～20, Fructus Jujubae 0.5～20, Rhizoma Zingiberis 0.5～10, Flos Chrysanthemi Indici 0.05～5.

6. the compositions of prevention as claimed in claim 1 or treatment flu is characterized in that crude drug also comprises: Radix Ginseng, Fructus Lycii, Arillus Longan, the Radix Astragali, Radix Glycyrrhizae and Folium Camelliae sinensis.

7. compositions as claimed in claim 6, the weight portion proportioning that it is characterized in that described crude drug is Radix Ginseng 0.01～1, Fructus Lycii 0.05～5, Arillus Longan 0.01～10, the Radix Astragali 0.01～5, Radix Glycyrrhizae 0.01～10, Folium Camelliae sinensis 0.1～1.

8. compositions as claimed in claim 7, the weight portion proportioning that it is characterized in that described crude drug is Radix Ginseng 0.1～0.5, Fructus Lycii 0.1～2.5, Arillus Longan 0.1～5, the Radix Astragali 0.1～3, Radix Glycyrrhizae 0.1～5, Folium Camelliae sinensis 0.1～0.5.

9. the preparation method of a prevention or treatment flu compositions comprises following step of carrying out:

1) prepare crude drug according to following weight portion proportioning:

10. preparation method as claimed in claim 9 is characterized in that the weight portion proportioning of described crude drug is: brown sugar 0.5～20, Fructus Jujubae 0.5～20, Rhizoma Zingiberis 0.5～10, Flos Chrysanthemi Indici 0.05～5, Radix Ginseng 0.1-0.5, Fructus Lycii 0.1-2.5, Arillus Longan 0.1-5, Radix Astragali 0.1-3, Radix Glycyrrhizae 0.1-5, Folium Camelliae sinensis 0.1-0.5.