CN103446525B - Treat dermopathic Chinese medicine composition and its preparation method and application - Google Patents
Treat dermopathic Chinese medicine composition and its preparation method and application Download PDFInfo
- Publication number
- CN103446525B CN103446525B CN201210183904.3A CN201210183904A CN103446525B CN 103446525 B CN103446525 B CN 103446525B CN 201210183904 A CN201210183904 A CN 201210183904A CN 103446525 B CN103446525 B CN 103446525B
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- medicine composition
- weight
- psoriasis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses one kind to treat dermopathic Chinese medicine composition and its preparation method and application, treats dermopathic Chinese medicine composition, for what is be prepared into using the raw material of following parts by weight：5~15 parts of the radix paeoniae rubrathe, 5~15 parts of curcuma zedoary, 5~25 parts of smilax, 5~25 parts of Glabrous Sarcandra Herb.The dermopathic Chinese medicine composition for the treatment of of the present invention, using tcm theory, both symptoms and root causes, in a short time can relief of symptoms, effect protrudes, and prolonged application, without toxic side effect, clinical practice has the effect of preferable.
Description
Technical field
The present invention relates to one kind to treat dermopathic Chinese medicine composition, and in particular to one kind treats psoriasis Chinese medicine composition
And its preparation method and application.
Background technology
Skin disease, as psoriasis (Psoriasis) is commonly called as psoriasis, be a kind of common chronic, recurrent and with it is immune
Related disease.Clinical manifestation is on the basis of wellability erythema, is coated to multilayer silvery white phosphorus bits.Unlike other diseases
Although about 80% patient only has pruritis, because skin lesion outward appearance is indecency, psoriatic is caused to experience seriously
Psychological pressure, feel oneself inferior, lose, or even introgression, the strong influence life quality of patient.Modern medicine thinks this disease
The reason for be immune system dysfunction, commonly used (for oral administration or external application) immunodepressant of its treatment, and skin can be improved
Damage the cortin or the medicine such as coal tar of symptom, such as anthraline, its salts, tazarotene, injected under skin lesion cortin or
Diying Tablet for oral administration, the methods of retinoid, antineoplastic, although short-term relief symptom effect is fine, prolonged application all has
Serious toxic side effect, clinic still lack the medicine of good effect, Small side effects.
The content of the invention
It is an object of the invention to provide one kind to treat dermopathic Chinese medicine composition and its preparation method and application, to overcome
Drawbacks described above existing for prior art.
The dermopathic Chinese medicine composition for the treatment of of the present invention, for what is be prepared into using the raw material of following parts by weight：
5~15 parts of the radix paeoniae rubrathe, 5~15 parts of curcuma zedoary, 5~25 parts of smilax, 5~25 parts of Glabrous Sarcandra Herb；
Preferably, it is to be prepared into using the raw material of following parts by weight：
7~12 parts of the radix paeoniae rubrathe, 7~12 parts of curcuma zedoary, 10~20 parts of smilax, 10~20 parts of Glabrous Sarcandra Herb；
It is further preferred that it is prepared into using the raw material of following parts by weight：
8~10 parts of the radix paeoniae rubrathe, 8~10 parts of curcuma zedoary, 14~16 parts of smilax, 14~16 parts of Glabrous Sarcandra Herb；
Most preferably, it is to be prepared into using the raw material of following parts by weight：
9 parts of the radix paeoniae rubrathe, 9 parts of curcuma zedoary, 15 parts of smilax, 15 parts of Glabrous Sarcandra Herb；
The invention further relates to a kind of pharmaceutical composition, including the above-mentioned Chinese medicine composition of therapeutically effective amount and pharmaceutically
Acceptable carrier, the carrier refer to the conventional carrier of pharmaceutical field, such as：Diluent, excipient such as water etc.；Adhesive is such as
Cellulose derivative, gelatin, polyvinylpyrrolidone etc.；Filler such as starch etc.；Burst apart agent such as calcium carbonate, sodium acid carbonate；Separately
Outside, other adjuvants such as flavouring agent and sweetener can also be added in the composition.
For it is oral when, conventional solid pharmaceutical preparation such as tablet, pulvis or capsule etc. can be prepared into；
One of preparation method of the present invention, comprises the following steps：
Above-mentioned each medicinal material is pulverized and mixed respectively, 90~12 mesh sieves is crossed, is then directly reloaded into capsule, or and pharmacy
Upper acceptable carrier mixing loads capsule or is compressed to tablet；
The two of the preparation method of the present invention, comprise the following steps：
Above-mentioned Chinese medicine material is ground into the coarse powder of 10~30 mesh, then adds the second that 8~12 times of volumetric concentrations are 65~95%
Extract 1~9 hour, preferably extract 2~3 times, 0.5~3 hour every time, extract solution was condensed into dry extract, powder at a temperature of alcohol reflux
Being prepared after broken turns into solid dosage forms, or extract solution is condensed into the medicinal extract that Baume degrees is 1.2~1.4, then with pharmaceutically may be used
The carrier mixing of receiving, is prepared into various solid dosage forms；
The three of the preparation method of the present invention, comprise the following steps：
By above-mentioned Chinese medicine material, add and extracted under the water reflux temperature of 8-15 times of weight 1~9 hour, preferably extracted 2~3 times,
0.5~3 hour every time, extract solution was concentrated into 1mL and contains 1.5~2.5 grams of medicinal materials, add ethanol to the volumetric concentration of alcohol for 65~
75%, precipitates overnight, filtering, filtrate decompression concentration, ethanol is removed, thick paste or dried cream powder is condensed into or is spray-dried to obtain medicinal extract
Powder, then mixed with pharmaceutically acceptable carrier, prepare various solid pharmaceutical preparations；
The four of the preparation method of the present invention, comprise the following steps：
By above-mentioned Chinese medicine material, add and extracted under the water reflux temperature of 8-15 times of weight 1~9 hour, preferably extracted 2~3 times,
0.5~3 hour every time, extract solution was concentrated into 1mL and contains 1.5~2.5 grams of medicinal materials, add ethanol to the volumetric concentration of alcohol for 65~
75%, precipitates overnight, filtering, filtrate decompression concentration, ethanol is removed, be condensed into the medicinal extract that Baume degrees is 1.15-1.4, Ran Houyu
Pharmaceutically acceptable topical carrier mixing, is prepared into external preparation.
Inventors believe that psoriasis is due to groups of people because constitution is intolerant to, insufficiency of natural endowment, the evil intrusion people of poison
Body, skin space between skin and muscles is gathered, and cause qi and blood stagnation, battalion, which defends, to be become estranged, and channels and collaterals obstruction, poison heresy is accumulate long, and outgoing skin forms skin disease；And
Psoriasis is then damaged with internal organs, and vim and vigour are become estranged, and is sought many pathological factors such as Wei Buchang, pathogen usually intruding into collateral in protracted disease, is caused evil poison to hold back volt machine eventually
Table, new blood are difficult to supplement nutrition, and ecchymosis is difficult to lead off, therefore are seted forth one's views with the dry malicious stasis of blood when treating, with enriching the blood to restore normal menstruation, based on removing pattogenic heat from the blood and toxic material from the body,
Assistant is with the product of disperse blood stasis and dredge collateral.According to this principle, inventor preferably obtains above-mentioned prescription in substantial amounts of experiment.
In prescription：
Radix paeoniae rubrathe clearing heat and cooling blood, ying blood is set to recover and circulate without hindrance；Curcuma zedoary blood-breaking dissipating bind, Glabrous Sarcandra Herb smilax removing toxicity for detumescence,
Immunity of organism metabolism is adjusted, all medicines share, plays promoting blood circulation and removing blood stasis, clearing heat and detoxicating, dredging the channel, flourish the effect of supporting skin altogether.
Animal experiment proves the dermopathic Chinese medicine composition for the treatment of of the invention, there is good treatment for treatment psoriasis
Effect, it can be used for treating psoriasis.
The patient for needing to treat can be put on by oral, topical route, dosage is generally：Oral 40~50/ body weight
My god, it can specifically be determined according to age of patient, state of an illness etc. by doctor；
Animal experiment proves that the dermopathic Chinese medicine composition for the treatment of of the invention, toxicity is smaller, even if long-term use of,
There is no toxic side effect.
The dermopathic Chinese medicine composition for the treatment of of the present invention, using tcm theory, both symptoms and root causes, can alleviate disease in a short time
Shape, effect protrude, and prolonged application, without toxic side effect, clinical practice has the effect of preferable.
Embodiment
Embodiment 1
The preparation of tablet：
Raw materials of traditional Chinese medicinal materials is weighed according to following deal：
9 parts of the radix paeoniae rubrathe, 9 parts of curcuma zedoary, 15 parts of smilax, 15 parts of Glabrous Sarcandra Herb；
Coarse powder by above-mentioned pulverizing medicinal materials into 20 mesh, flowed back twice by the extraction of 70% ethanol of 10 times of bulking value concentration,
2 hours every time, merge extract solution, extract solution is condensed into the medicinal extract that Baume degrees is 1.3, adds the starch of the medicinal extract weight 50% to mix
Close, pelletize, dry, the magnesium stearate for adding the medicinal extract weight 3% is well mixed, and beats piece, obtains tablet.
Embodiment 2
The preparation of capsule：
Raw materials of traditional Chinese medicinal materials is weighed according to following deal：
10 parts of the radix paeoniae rubrathe, 8 parts of curcuma zedoary, 16 parts of smilax, 16 parts of Glabrous Sarcandra Herb；
Above-mentioned medicinal material drying, is ground into 100 targeted fine powders, adds the magnesium stearate of fine powder weight 3%, enters capsule.
Embodiment 3
The preparation of pill
Raw materials of traditional Chinese medicinal materials is weighed according to following deal：
8 parts of the radix paeoniae rubrathe, 10 parts of curcuma zedoary, 14 parts of smilax, 16 parts of Glabrous Sarcandra Herb；
The water reflux temperature that above-mentioned medicinal material adds 10 times of weight is extracted, extraction time is 1.5 hours, and extract solution is concentrated into
1mL contains 2 grams of medicinal materials, and it is 70% to add ethanol to alcohol volumetric concentration, precipitates overnight, filtering, and filtrate decompression concentration is thick medicinal extract；It is dry
Dry, it is ball that water is general, coating.
Embodiment 4
The preparation of oral liquid：
9 parts of the radix paeoniae rubrathe, 10 parts of curcuma zedoary, smilax 14,15 parts of Glabrous Sarcandra Herb；
Above-mentioned medicinal material adds the water refluxing extraction 0.5 hour of 12 times of weight, and extract solution is concentrated into 1mL and contains 2 grams of medicinal materials, adds ethanol
Volumetric concentration to alcohol is 70%, precipitates overnight, filtering, filtrate decompression concentration, removes ethanol, filters, filtrate is added in filtrate
The Tween-80 of weight 3%, benzoic acid, the sodium benzoate of filtrate weight 0.05% of filtrate weight 0.05%, mix, packing is wet
Vapours sterilizes, and obtains oral liquid.
Embodiment 5
The preparation of externally-applied liniment：
9 parts of the radix paeoniae rubrathe, 9 parts of curcuma zedoary, 15 parts of smilax, 15 parts of Glabrous Sarcandra Herb；
By above-mentioned pulverizing medicinal materials into 10 mesh coarse powder, two are extracted by 70% alcohol reflux of 10 times of weight amount volumetric concentrations
It is secondary, 3 hours every time, merge extract solution, it is 3% to be concentrated under reduced pressure into containing alcohol weight, obtains concentrate, adds concentrate weight 1%
Borneol, the sodium benzoate of concentrate weight 0.1%, obtain liniment；Or add the borneol of concentrate weight 1%, concentrate weight
The polyvinyl alcohol of amount 20%, obtain plastics.
Embodiment 6
The present embodiment uses rat-tail scale as test model, and the medicine of the present invention is tested.
Psoriatic's skin structure approaches with mouse tail skin, therefore is the conventional mould for evaluating psoriasis curative effect
Type.Drugs compared is composition disclosed in marketed products Diying Tablet.
1.1 experimental animal
Kunming mouse 60, male 30, female 30.20~25g of body weight.It is grouped using random digits table,
Mouse each in colony, is divided into 3 groups by male and female by body weight, and mouse weight is same or like in every group, and each group is male and female
Number is identical, and 3 groups of generation are saline control group respectively, the medicine group of the embodiment of the present invention 1, positive drug Diying Tablet
Group；
1.2 administrations and dosage
Saline control group gives the distilled water of isometric(al), and (dosage is medicinal material to medicine group of the invention administration 20g/kg
Amount), positive drug administration 0.13g/kg, administration volume is 0.2ml/10g；
1.3 experimental procedure
With irrigation stomach device gastric infusion, once a day, mouse continuous gavage 15 days, during medication, claimed body at interval of 2 days
Weight, to adjust dosage, 1h after last day gavage, cervical dislocation puts to death mouse, takes mouse rat-tail away from skin at the 1.8cm of root
The strip of skin one, it is stored in 10% methanol physiological saline fixer.Conventional organization is cut into slices, HE dyeing, light Microscopic observation, a squama
Piece has continuous rows of Granulosa cells to be then determined as the scale for having stratum granulosum to be formed, and counting in continuous 100 scales has particle
The scale number of layer.Using SPSS softwares, data processing and statistics are carried out, measurement data is represented using number ± standard deviation, between group
Compare and use one-way analysis of variance, compare examined using least significant difference two-by-two, it is anon-normal too or heterogeneity of variance, using sum of ranks
Examine, and it is with statistical significance to set P ＜ 0.05.
Experimental result see the table below：
Influence of the medicine of the present invention to mouse rat-tail scale
From result of the test, compared with control group, Diying Tablet group and present invention group medicine can remarkably promote rat-tail squama
The formation of piece stratum granulosum, there is pole significant difference compared with control group, and medicine of the present invention is better than commercially available Diying Tablet.
Embodiment 7
The present embodiment uses female mice vaginal basal cell as test model, and the medicine of the present invention is tested.Female mice is cloudy
Epidermal differentiation of the road epithelium under diethylstilbestrol stimulation is too fast, has silk to divide the phenomenon and psoriasis table that columns increases and differentiation is not complete
Skin excessively differentiation and differentiation it is infull the characteristics of it is identical, therefore female mice vagina epithelium experiment and psoriasis often with pathological model it
One.
1 experimental animal
Kunming mouse 80, female, is assigned in 3 groups with random digits table, is respectively：Physiological saline group, this hair
The medicine group of bright embodiment 1, positive drug Diying Tablet group；
2 dosages
Saline control group gives the distilled water of isometric(al), medicine group of the invention administration 20g/kg, positive drug group
0.13g/kg is administered, administration volume is 0.2ml/10g；
3 experimental procedures
In addition to physiological saline group, remaining each group mouse notes diethylstilbestrol 0.2ml/ only, 1 time a day.Continuous 4 days.5th day
Start gavage, continuous gavage 7 days, 1 hour after last day gavage, injection colchicin 2mg/kg.6h after injection, cervical dislocation
Mouse is put to death, vagina tissue is removed immediately, is stored in 10% formaldehyde physiological saline fixer.Conventional organization is cut into slices, HE dyeing, light
Microscopic observation, count the mitosis number in every 100 basal cells.
4 experimental datas see the table below
Medicine of the present invention is on the mitotic influence of mouse vagina epithelium
From result of the test, model group mouse vagina epithelium dramatically increases compared with control group, illustrates modeling success；This
There were significant differences compared with model group for invention group and positive drug group, illustrates that medicine and Diying Tablet of the present invention can significantly press down
The exception of mouse vagina epithelium processed has silk separation.
The experiment of the medicine of other embodiments of the invention, it is as a result similar.
Embodiment 8
Anxious poison experiment
Experimental animal：Kunming mouse, female 12, male 13,18~22g of body weight；
Medicine：The alcohol extract 2.53g/ml of embodiment 1
Experimental procedure：
1. mouse adaptability is fed 3~4 days, body weight control is within 22g
2. water 12h is can't help in fasting before mouse administration；
3. mouse, is assigned in blank group and administration group, every group 12, male and female half and half by packet with random digits table.
4. administration, blank group give physiological saline, administration group gives four taste side's alcohol extracts.Gavage amount 0.25ml/10g.
Twice a day.Administration is superposed to 158 times twice equivalent to 79 times of people's clinical dosage for the first time.
Experimental result：After gavage, mouse activity is reduced, anorexia, after 24 hours, is gradually recovered.After 48 hours, completely
Normally.It is continuous to feed 1 week, occur without abnormal.General mortality rate 0.According to the experience of Chinese medicine studies on acute toxicity,
It is believed that this patent medicine is safe.
Claims (5)
1. treat the Chinese medicine composition of psoriasis, it is characterised in that it is prepared into using the raw material of following parts by weight：The radix paeoniae rubrathe 7
~12 parts, 7~12 parts of curcuma zedoary, 10~20 parts of smilax, 10~20 parts of Glabrous Sarcandra Herb.
2. the Chinese medicine composition for the treatment of psoriasis according to claim 1, it is characterised in that be to use following parts by weight
What raw material was prepared into：8~10 parts of the radix paeoniae rubrathe, 8~10 parts of curcuma zedoary, 14~16 parts of smilax, 14~16 parts of Glabrous Sarcandra Herb.
3. the Chinese medicine composition for the treatment of psoriasis according to claim 1, it is characterised in that be to use following parts by weight
What raw material was prepared into：9 parts of the radix paeoniae rubrathe, 9 parts of curcuma zedoary, 15 parts of smilax, 15 parts of Glabrous Sarcandra Herb.
4. one kind treats psoriasis composition, it is characterised in that by any one of claims 1 to 3 of therapeutically effective amount institute
The Chinese medicine composition for the treatment psoriasis stated and pharmaceutically acceptable carrier composition.
5. the Chinese medicine composition of the treatment psoriasis described in any one of claims 1 to 3 is in treatment psoriasis is prepared
Using.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210183904.3A CN103446525B (en) | 2012-06-05 | 2012-06-05 | Treat dermopathic Chinese medicine composition and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210183904.3A CN103446525B (en) | 2012-06-05 | 2012-06-05 | Treat dermopathic Chinese medicine composition and its preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103446525A CN103446525A (en) | 2013-12-18 |
| CN103446525B true CN103446525B (en) | 2018-03-20 |
Family
ID=49729637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210183904.3A Active CN103446525B (en) | 2012-06-05 | 2012-06-05 | Treat dermopathic Chinese medicine composition and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103446525B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106139382A (en) * | 2015-04-14 | 2016-11-23 | 上海暖友实业有限公司 | A kind of spontaneous heating breast health promotion patch and its preparation method and application |
| CN106137727A (en) * | 2015-04-16 | 2016-11-23 | 上海暖友实业有限公司 | A kind of spontaneous heating foot health promotion patch |
| CN106137523A (en) * | 2015-04-17 | 2016-11-23 | 上海暖友实业有限公司 | Spontaneous heating joint care patch and preparation method thereof |
| CN106138013A (en) * | 2015-04-17 | 2016-11-23 | 上海暖友实业有限公司 | A kind of spontaneous heating lumbar vertebra cervical-vertebra health care patch and preparation method thereof |
| CN105213971B (en) * | 2015-10-15 | 2019-01-22 | 广东省中医院 | The Chinese medicine composition for treating psoriasis |
| CN114939151A (en) * | 2022-06-22 | 2022-08-26 | 张成强 | Traditional Chinese medicine decoction for treating psoriasis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101559202A (en) * | 2009-05-08 | 2009-10-21 | 武汉理工大学 | Zedoary turmeric oil adhesive membrane for external application and preparation method thereof |
| CN101632827A (en) * | 2009-08-21 | 2010-01-27 | 广州中医药大学第二临床医学院 | Traditional Chinese medicine composite for treating psoriasis and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009080842A1 (en) * | 2007-12-21 | 2009-07-02 | Asac Compañía De Biotecnología E Investigación Sa | Photoprotective compositions |
-
2012
- 2012-06-05 CN CN201210183904.3A patent/CN103446525B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101559202A (en) * | 2009-05-08 | 2009-10-21 | 武汉理工大学 | Zedoary turmeric oil adhesive membrane for external application and preparation method thereof |
| CN101632827A (en) * | 2009-08-21 | 2010-01-27 | 广州中医药大学第二临床医学院 | Traditional Chinese medicine composite for treating psoriasis and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 禤国维治疗银屑病经验;曲永彬;《当代名医》;20060930;第47卷(第9期);第654页 * |
| 银屑灵片处方优化的实验研究及临床探索性研究;闫玉红;《中国博士学位论文全文数据库 医药卫生科技辑》;中国学术期刊(光盘版)电子杂志社;20100915(第9期);第27-29页 * |
| 银屑病的中医药治疗;孙虹;《皮肤病与性病》;20110228;第33卷(第1期);第16-17页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103446525A (en) | 2013-12-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103446525B (en) | Treat dermopathic Chinese medicine composition and its preparation method and application | |
| CN104547826B (en) | Galangal rhizome extract treats the medical usage of dysmenorrhoea | |
| CN101708241A (en) | Medicinal composition for eliminating dampness and relieving itching | |
| CN102526668B (en) | Ginger/white pepper composition for relieving vomiting due to cancer chemotherapy and enhancing effect of cancer chemotherapy and preparation method thereof | |
| CN104352624B (en) | Application of the anaesthetic core fragrant plant n-butanol extract in preventing and treating diabetes medicament is prepared | |
| CN103271947A (en) | Novel antitumor application of maggot | |
| CN101209296A (en) | Chinese medicinal granule with worm-expelling liver-caring, hemostasis and dysentery-stopping efficacy | |
| CN103239636A (en) | Application of reed rhizome extract and gingerol in preparation of attenuated synergistic medicines for cancer chemotherapy | |
| CN115120689A (en) | Application of Xinli rehabilitation formula preparation in preparation of medicines | |
| CN104435567A (en) | Traditional Chinese medicinal composition containing gynostemma pentaphyllum for treating gout | |
| CN1939427A (en) | Prickly polygonum extract, its preparation, medicinal composition and use | |
| CN104800690B (en) | A kind of Chinese medicine of anti-trioxypurine and preparation method thereof | |
| CN103610795A (en) | Method for preparing eucommia ulmoides step-down oral preparation | |
| CN103948899B (en) | A kind of Tibetan medicine for the treatment of atrophic gastritis | |
| CN102327304B (en) | Drug for preventing and controlling chronic mountain sickness and preparation method thereof | |
| CN104352672A (en) | Tortoise plastron-containing traditional Chinese medicine composition for treating diabetes | |
| CN104337898B (en) | A kind of Chinese medicine composition of the treatment gout containing Semen Pruni | |
| CN103893512B (en) | A kind of Chinese medicine composition for treating urarthritis | |
| CN103751239B (en) | A kind of preparation method and applications of Radix Et Caulis Acanthopanacis Senticosi total glucosides and manyprickle acanthopanax general glycosides formulation | |
| CN102836315A (en) | Chinese medicinal composition for preventing and conditioning prognosis tumors and preparation method thereof | |
| CN102293816B (en) | Production method of rheumatism dripping pill | |
| CN101607009B (en) | Pharmaceutical composition for treating cold | |
| CN106620045A (en) | Preparation method and application of 95% ethanol extract of clerodendrum japonicum roots | |
| CN107213323B (en) | Chinese medicinal compound preparation for nourishing yin, eliminating phlegm, resolving masses and detoxifying and application thereof | |
| CN106902330B (en) | Traditional Chinese medicine preparation for treating rheumatic arthritis and rheumatalgia and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |