CN103239636A - Application of reed rhizome extract and gingerol in preparation of attenuated synergistic medicines for cancer chemotherapy - Google Patents
Application of reed rhizome extract and gingerol in preparation of attenuated synergistic medicines for cancer chemotherapy Download PDFInfo
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Abstract
The invention relates to a natural pharmaceutical composition, a preparation method of the natural pharmaceutical composition, and an application of the natural pharmaceutical composition in preparation of attenuated synergistic medicines for cancer chemotherapy. The natural pharmaceutical composition is prepared from reed rhizome extract and gingerol according to the ratio of (3-24):1. The composition has an excellent curative effect on side effects such as vomiting and the like caused by cancer chemotherapy, and can play a role in inhibiting tumors.
Description
Technical field
The present invention relates to a kind of natural drug composition, relate more specifically to the natural drug composition that a kind of Rhizoma Phragmitis extract and gingerol are formed, the preparation method of this natural drug composition and this natural drug composition are for the preparation of the purposes that reduces in the vomiting side effect that cancer chemotherapy causes and the medicine that the treatment cancer is played potentiation.
Background technology
Cancer has become the big killer that the mankind face at present, though chemotherapy has certain curative effect, after the chemotherapy most of patient can feel sick, gastrointestinal reaction such as vomiting.Vomiting can cause Digestive system to be lost in a large number frequently, and water, electrolyte, acid base imbalance make patient agonizing, have a strong impact on patient's life quality, not only can have influence on curative effect, even make patient be difficult to stand and therapy discontinued.
At present, clinical Bendectin commonly used mainly contains histamine, acetylcholine and dopamine receptor antagonistic and cannabis medicine etc., but the weak curative effect that these medicines are vomitted after to chemotherapy, and toxic and side effects is strong, is very limited in the application.Novel Bendectin is as NK
1Receptor antagonist and 5-HT
3Receptor antagonist class medicine, though good, expensive to vomiting antiemetic effect after the chemotherapy, the scope of application is narrow, and toxicity is big, clinical many need drug combinations, and do not see the anticancer synergia effect, the development of the natural anti-cancer attenuation synergistic medicine that therefore waits in expectation.
Chinese medicine Rhizoma Zingiberis Recens (zingiber) is described as " vomiting panacea ".Gingerol is the active ingredient that extracts from Rhizoma Zingiberis Recens, the inventor observe gingerol can resist inorganic and organic poison copper sulfate and cisplatin due to vomit, and suppress the intestinal pheochromocyte and discharge to cause and tell factor 5-HT and P material, gingerol acts on the maximally related NK of emesis of chemotherapy
1And 5-HT
3Deng receptor, be many target spots, natural low toxicity Bendectin.Rhizoma Phragmitis is for being the fresh or dry rhizome of monocotyledon grass family phragmites communis.Return lung meridian, stomach warp, can promote the production of body fluid, preventing or arresting vomiting, diuresis.In recent years, the Rhizoma Zingiberis Recens antitumaous effect is confirmed, especially gingerol, the inventor is through research and experiment and the clinical practice of each a large amount of formula proportion, obtained optimal drug ratio compositions of the present invention at last, be the compositions of the novelty of agreeing with mutually with polyceptor target spot ratio, and proved that its side effect such as vomiting that cancer chemotherapy is caused has fabulous curative effect and can play the auxiliary effect that suppresses tumor simultaneously, has finished the present invention thus.
Summary of the invention
First purpose of the present invention is to provide a kind of natural drug composition, and the said composition low toxicity is efficient, determined curative effect, is convenient to use and promotes, both can antitumor, can resist side effect such as vomiting grade after the chemotherapy again.
Second purpose of the present invention is to provide the preparation method of above-mentioned natural drug composition.
The 3rd purpose of the present invention is to provide the purposes of above-mentioned natural drug composition in preparing the medicine that reduces the cancer chemotherapy side effect and the treatment cancer is played the efficacy enhancing and toxicity reducing effect.
A kind of natural drug composition provided by the invention, by Rhizoma Phragmitis extract and gingerol by weight in 3-24: 1 ratio is formed.
Above-mentioned natural drug composition, wherein the usage ratio of Rhizoma Phragmitis extract, gingerol is 24: 1.
Wherein, Rhizoma Phragmitis extract, gingerol can be by well known to a person skilled in the art the conventional method acquisition of purifying, gingerol can commerce be buied, and the natural drug of the present invention that adopts these compositions of conventional method acquisition or adopt the commercial one-tenth of buying to be grouped into all can obtain identical curative effect.The method of below listing only is that the inventor thinks preferred method, and is not intended to the extracting method of each composition in this natural drug composition is made special restriction.
The Rhizoma Phragmitis extract preparation method is in the above-mentioned natural drug composition:
Get Rhizoma Phragmitis, drying is pulverized, and sieves, with 7-10 times of soak with ethanol 12h, cross the leaching clear liquor, residue continues to soak 12h, and twice filtrate is merged centrifugal (3000rpm) 15 minutes, separation of supernatant, ethanol is removed in distillation, and drying under reduced pressure becomes dry extract again, pulverizes, and crosses 100 mesh sieves, namely.
The preparation method of gingerol is in the above-mentioned natural drug composition:
Rhizoma Zingiberis Recens is thinly sliced, and natural drying breaks into powder with the high speed Universalpulverizer, crosses 30 mesh sieves, and the fine powder that will sieve is again put into the big port grinding bottle of 5000mL, to soak 72h under 6 times of amount acetone room temperature; At 40 ℃, supersound extraction 15min under the ultrasonic frequency of 40KHz, the centrifugal supernatant that obtains, residue discards; With supernatant decompress filter again, filtrate places the Rotary Evaporators vacuum concentration to get Rhizoma Zingiberis Recens and extracts mixture, and carrying out this mixture repeatedly again, the concentrate drying purification obtains gingerol.
The present invention also provides the preferred manufacturing procedure of this natural drug composition, comprising:
(1) Rhizoma Phragmitis extract preparation
Get Rhizoma Phragmitis, drying is pulverized, and sieves 6 times of distilled water distilled water immersions, decoction, filtration, medicinal residues add 6 times of distilled water again, soak, decoct, filter with method, and twice filtrate is merged centrifugal 15 minutes of 3000rpm, separation of supernatant, drying under reduced pressure becomes dry extract, pulverizes, and sieves namely;
(2) preparation of gingerol
Rhizoma Zingiberis Recens is thinly sliced, and natural drying breaks into powder with the high speed Universalpulverizer, crosses 30 mesh sieves, and the fine powder that will sieve is again put into the big port grinding bottle of 5000mL, to soak 72h under 6 times of amount acetone room temperature; At 40 ℃, supersound extraction 15min under the ultrasonic frequency of 40KHz; The centrifugal supernatant that obtains, residue discards; With supernatant decompress filter again, filtrate places the Rotary Evaporators vacuum concentration to get oil of ginger shape mixture, and carrying out this mixture repeatedly again, the concentrate drying purification obtains gingerol.
(3) choose Rhizoma Phragmitis extract, gingerol in proportion, evenly mix, namely.
The preparation method of above-mentioned natural drug composition, also comprise: the product that step (3) makes is further made the capsule that contains natural drug composition 100mg or 200mg specification by the pharmacy means of routine, maybe will make the tablet that contains natural drug composition 100mg or 200mg specification by wet granulation technology.
The present invention comprises that also natural drug composition reduces the cancer chemotherapy side effect and the treatment cancer played purposes in the medicine of potentiation in preparation, and reduces purposes in the vomiting reaction that cancer chemotherapy causes and the medicine that the treatment cancer is played potentiation in preparation.
The instructions of taking of natural drug composition of the present invention: the available capsule of vomiting or tablet behind the treatment cancer chemotherapy, 600mg divides three times one after each meal for each person every day.
The beneficial effect of natural drug composition of the present invention aspect resisting emesis and inhibition tumor is as follows:
1, natural drug composition of the present invention has good resisting emesis effect, has now finished clinical preceding pharmaceutical research at mink vomiting model.The mink vomiting model that adopts us to initiate is observed this natural drug composition cisplatin is caused the antagonism over a period to come of mink vomiting model.Studies show that: this natural drug composition has tangible antagonism for the vomiting reaction of mink due to the cisplatin, and its effect is better than independent gingerol.
2, natural drug composition of the present invention has the effect that suppresses tumor, has now finished clinical preceding pharmaceutical research on mouse tumor model.Adopt mouse tumor model, observed natural drug composition to the inhibitory action of mouse interior tumor.Studies show that: this natural drug composition has the obvious suppression effect for mouse interior tumor.
3, finished simultaneously in the research of the acute toxicology of mice, studies show that: this natural drug composition does not have influence to feed and behavioral activity etc., and internal organs and pathological observation be no abnormality seen also.Illustrate that this natural drug composition toxicity is very little.
4, the inventor makes up Rhizoma Phragmitis extract, gingerol originally, and by the consumption proportion between definite these components of a large amount of experiments, makes said composition bring into play good synergism, obtains unexpected effect.Pass through our experimentation repeatedly, make the inventor surprised be ratio between each component of natural drug composition of the present invention at 3-24: produced unexpected synergism at 1 o'clock, potentiation is obvious, extraordinary effect is played in side effect, especially the usage ratio of each component be 24: 1 o'clock especially obvious, this is that the inventor pays a large amount of creative works by keeping punching and obtains on the paper basis of delivering before, and those of ordinary skills only can't simply obtain this ratio range and optimum amount ratio by disclosed content.
5, this natural drug composition Rhizoma Phragmitis extract, each component of gingerol all can obtain by conventional means, also can buy by commerce, and such compositions itself has the convenience of acquisition, lower-cost effect.This also is the product that has splendid curative effect and higher industrial practicality concurrently that the inventor obtains by a large amount of creative work sides.
The specific embodiment
Further set forth the preparation of natural drug composition of the present invention below by embodiment and test example, with and the beneficial effect in resisting emesis and antitumor, used.
Embodiment
The first step: the preparation of various extracts
(1) Rhizoma Phragmitis extract preparation
Get Rhizoma Phragmitis, drying is pulverized, and sieves 6 times of distilled water distilled water immersions, decoction, filtration, medicinal residues add 6 times of distilled water again, soak, decoct, filter with method, and twice filtrate is merged centrifugal 15 minutes of 3000rpm, separation of supernatant, drying under reduced pressure becomes dry extract, pulverizes, and sieves namely.
(2) preparation of gingerol
Rhizoma Zingiberis Recens is thinly sliced, and natural drying breaks into powder with the high speed Universalpulverizer, crosses 30 mesh sieves, and the fine powder that will sieve is again put into the big port grinding bottle of 5000mL, to soak 72h under 6 times of amount acetone room temperature; At 40 ℃, supersound extraction 15min under the ultrasonic frequency of 40KHz; The centrifugal supernatant that obtains, residue discards; With supernatant decompress filter again, filtrate places the Rotary Evaporators vacuum concentration to get oil of ginger shape mixture, and carrying out this mixture repeatedly again, the concentrate drying purification obtains gingerol.
Second step: the preparation of preparation
(1) preparation of natural drug composition capsule preparations of the present invention
Take by weighing respectively the Rhizoma Phragmitis extract 96mg of above-mentioned steps preparation and gingerol 4mg,, take by weighing starch 395mg, magnesium stearate 5mg simultaneously, evenly mix, filled capsules is made the capsule of each pure heavy 500mg.
(2) preparation of natural drug composition tablet of the present invention
Take by weighing respectively the Rhizoma Phragmitis extract 96mg of above-mentioned steps preparation and gingerol 4mg,, take by weighing starch 295mg, lactose 100mg simultaneously, evenly mix, with wet granulation, drying, mix with the 5mg magnesium stearate behind the granulate, tabletting is made the tablet of every pure heavy 500mg.
Drug effect and pharmacology's data:
Compositions is in following test example: the usage ratio of Rhizoma Phragmitis extract, gingerol is 24: 1.The inventor to above-mentioned each composition usage ratio at 3-24: the compositions that the multiple proportioning combination in the time of between 1 obtains has been carried out and last identical experiment, find that all the natural drug composition in this amount ranges can obtain good synergism, can play good effect and treatment for cancer is had potentiation the cancer chemotherapy side effect.And the inventor finds that Rhizoma Phragmitis extract, gingerol can also be the compositions that obtains with conventional means, and be not only the composition that obtains with above-mentioned method, the compositions that the mentioned component of buying that made by conventional means or commercial is formed has the identical effect of compositions that makes with said method, its experimental data is no longer enumerated here, and those skilled in the art can approve this.Below be drug effect and the pharmacology's data that preferred embodiment obtains:
Test example 1: the pharmacodynamic study of natural drug composition treatment vomiting effect
1, test material
(1) Rhizoma Phragmitis is bought by big pharmacy, medical insurance city, Qingdao, and Rhizoma Zingiberis Recens is purchased Yushan Hill degree of conquering east.
(2) cisplatin (cisplatin), Shandong Qilu Pharmaceutical Factory produces, lot number: 903005CE, 20mg/ props up.
(3) Ondansetron Hydrochloride injection, the pharmacy of Olympic Competition health, lot number: 090102,2ml:4mg.
(4) healthy adult mink, body weight 1.3-1.8kg, male, provided by special cultivation animal feeding center, Qingdao, every animal places the ferrum cage of 75cm * 50cm * 50cm separately, 24h natural light irradiation, ad lib drinking-water before the experiment.
2, test method:
Mink is divided into 4 groups at random, and 6 every group, the A group is the cisplatin model control group, and the B group is ondansetron positive drug group, and the C group is for being gingerol, and the E group is natural drug composition of the present invention (Rhizoma Phragmitis extract, gingerol were by 24: 1 mixed).The A group gives the normal saline pretreatment; The B group gives ondansetron 7.5m g.kg
-1Pretreatment; C organizes to giving gingerol 10g.kg
-1(being equivalent to contain the crude drug amount) ig pretreatment; The D group gives natural drug composition 10g.kg of the present invention
-1(being equivalent to contain the crude drug amount) ig pretreatment, each group all gives cisplatin 7.5mg.kg at administration 30min
-1Ip.For observing mink vomiting reaction in the 6h after administration, record its vomiting incubation period, retch and vomiting number of times.
3, experimental result
Compare with matched group, each treatment group all can obviously alleviate retch and vomiting number of times and prolong vomits incubation period (P＜0.01).Gingerol group, gingerol and Rhizoma Phragmitis extract compatibility group, Rhizoma Zingiberis Recens Rhizoma Phragmitis water boiling concentration extract group, and natural drug composition of the present invention can significantly reduce the rate of vomitting that causes.Wherein Rhizoma Zingiberis Recens Rhizoma Phragmitis water boiling concentration extract group is identical with the ondansetron group; And causing the rate of vomitting, natural drug composition group of the present invention is lower than the ondansetron group.The results are shown in Table 1.
Table 1 extract compatibility to cisplatin (7.5mg/kg, ip) cause vomit the effect influence (
N=6)
Annotate: a is equivalent to contain the crude drug amount, compares with matched group
cP＜0.01
Test example 2: the pharmacodynamic study of pharmaceutical composition antitumor action of the present invention
1, experiment material
(1) Kunming mouse, body weight 20 ± 2g is provided by Qingdao City medicine inspecting institute Experimental Animal Center.Ad lib drinking-water before the experiment, the 24h natural light irradiation.
(2) cyclophosphamide, the permanent auspicious medical Pharmacy stock Co., Ltd in Jiangsu product.
2, test method:
(1) to mice S
180The inhibition test of sarcoma growth
Employing was gone down to posterity 5-7 days, and well-grown milky ascites is diluted to tumor cell suspension with an amount of physiological saline solution, and cell number is 10
7/ mL, 12 every group, the right axillary fossa subcutaneous vaccination of every Mus 0.2mL (contains oncocyte 2 * 10
6Individual).Inoculation random packet next day, experimental group pharmaceutical composition of the present invention is divided into (200,100mg/mL) two dosage groups, every Mus is irritated stomach 0.5ml; Negative control group gives 0.5mL distilled water; The positive drug group gives cyclophosphamide 20gkg
-1D
-1, successive administration 10 days.The conventional raising, drinking-water, food is not limit.Drug withdrawal next day, mice all takes off cervical vertebra puts to death, and strips subcutaneous solid tumor tumor piece, weighs, and calculates tumor control rate (%) by following formula:
Tumor control rate=(the average tumor of the matched group average tumor of heavy (C)-experimental group heavy (T))/average tumor of matched group heavy (C)
(2) to rat liver cancer H
22The inhibition test of growth
Grouping, dosage, administering mode, experimental period and S
180The sarcoma strain is identical.
(3) to the inhibition test of mice ehrlich ascites tumor (solid tumor)
Grouping, dosage, administering mode, experimental period and S
180The sarcoma strain is identical.
3, result of the test
Three dosage groups of pharmaceutical composition of the present invention are to S
180, H
22, EAC and negative control group relatively, inhibitory action is in various degree all arranged, especially the highest to the suppression ratio of tumor with high dose group.(as table 2,3,4)
Table 2 composition capsule is to S
180The tumor inhibition effect of mice (
N=12)
Compare with matched group,
cP＜0.01
Table 3 composition capsule is to H
22The tumor inhibition effect of mice (
N=12)
Compare with matched group,
bP＜0.01
Table 4 composition capsule to the tumor inhibition effect of EAC mice (
N=12)
Compare with matched group,
cP＜0.01
Test example 3: the acute toxicity test of natural drug composition of the present invention
1, experimental animal:
Kunming mouse, body weight 20 ± 2g is provided by Qingdao City medicine inspecting institute Experimental Animal Center
2, medicine:
Natural drug composition of the present invention, tragakanta
3, test method:
Promulgate " the study of tcm new drug specification requirement " of revising one on November 12, in 999 according to National Drug Administration, natural drug of the present invention is carried out acute toxicity testing.Because being subjected to drug level and volume restrictions, can't measure LD
50So, carry out the maximum dosage-feeding experiment.Get 30 of Kunming mouses, female half and half, ig gives capsule Chinese medicine 1g/mL, every 0.8mL, and it is long-pending that namely the maximum of mice is irritated body of stomach, observes mice active state, diet, feces, breathing, body weight and death condition after the medication, observes 14d. continuously
4, result of the test:
Each organizes well-grown after the mouse stomach administration, weight increase, and behavior is normal, there is no death and significant reaction.Behind sacrifice of animal, the no abnormal phenomenon of each main organs of perusal.
The result shows that natural drug composition maximal dose oral application of the present invention does not have obvious damage to animal, does not find the toxic reaction to the body generation, is a kind of safe and reliable medicine.
Claims (5)
1. one kind is reduced vomiting reaction that cancer chemotherapy causes and the treatment cancer is played the natural drug composition of potentiation, and it is characterized in that said composition Rhizoma Phragmitis extract and gingerol are by weight in 3-24: 1 ratio is formed,
Wherein the preparation method of Rhizoma Phragmitis extract is:
Get Rhizoma Phragmitis, drying is pulverized, and sieves 6 times of distilled water distilled water immersions, decoction, filtration, medicinal residues add 6 times of distilled water again, soak, decoct, filter with method, and twice filtrate is merged centrifugal 15 minutes of 3000rpm, separation of supernatant, drying under reduced pressure becomes dry extract, pulverizes, and sieves, namely;
Wherein the preparation method of gingerol is:
Rhizoma Zingiberis Recens is thinly sliced, and natural drying breaks into powder with the high speed Universalpulverizer, crosses 30 mesh sieves, and the fine powder that will sieve is again put into the big port grinding bottle of 5000mL, to soak 72h under 6 times of amount acetone room temperature; At 40 ℃, supersound extraction 15min under the ultrasonic frequency of 40KHz, the centrifugal supernatant that obtains, residue discards; With supernatant decompress filter again, filtrate places the Rotary Evaporators vacuum concentration to get Rhizoma Zingiberis Recens and extracts mixture, and carrying out this mixture repeatedly again, the concentrate drying purification obtains gingerol.
2. natural drug composition as claimed in claim 1, wherein the usage ratio of Rhizoma Phragmitis extract and gingerol is 24: 1.
3. as the preparation method of the natural drug composition of claim 1 or 2, it is characterized in that this method comprises:
(1) preparation of Rhizoma Phragmitis extract
Get Rhizoma Phragmitis, drying is pulverized, and sieves 6 times of distilled water distilled water immersions, decoction, filtration, medicinal residues add 6 times of distilled water again, soak, decoct, filter with method, and twice filtrate is merged centrifugal 15 minutes of 3000rpm, separation of supernatant, drying under reduced pressure becomes dry extract, pulverizes, and sieves, namely;
(2) preparation of gingerol
Rhizoma Zingiberis Recens is thinly sliced, and natural drying breaks into powder with the high speed Universalpulverizer, crosses 30 mesh sieves, and the fine powder that will sieve is again put into the big port grinding bottle of 5000mL, to soak 72h under 6 times of amount acetone room temperature; At 40 ℃, supersound extraction 15min under the ultrasonic frequency of 40KHz, the centrifugal supernatant that obtains, residue discards; With supernatant decompress filter again, filtrate places the Rotary Evaporators vacuum concentration to get oil of ginger shape mixture, and carrying out this mixture repeatedly again, the concentrate drying purification obtains gingerol;
(3) choose Rhizoma Phragmitis extract in proportion, gingerol evenly mixes, namely.
4. the preparation method of natural drug composition as claimed in claim 3, also comprise: the product that step (3) makes is further made the capsule that contains natural drug composition 100mg or 200mg specification by the pharmacy means of routine, maybe will make the tablet that contains natural drug composition 100mg or 200mg specification by wet granulation technology.
5. reduce purposes in the vomiting reaction that cancer chemotherapy causes and the medicine that the treatment cancer is played potentiation as each described natural drug composition of claim 1-2 in preparation.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103919819A (en) * | 2014-04-21 | 2014-07-16 | 青岛中仁药业有限公司 | Poria cocos natural composition and anti-cancer vomit-preventing application thereof |
| CN105616442A (en) * | 2016-03-04 | 2016-06-01 | 青岛黄海学院 | Medicine composition for treating vomit and preparation method and application of medicine composition |
| CN106377748A (en) * | 2016-11-22 | 2017-02-08 | 青岛大学 | Pharmaceutical composition for relieving emesis and inhibiting cancer as well as preparation method and application of pharmaceutical composition |
| CN108697753A (en) * | 2016-02-18 | 2018-10-23 | 韩国韩医学研究院 | Contain composition for prevent, improve or treat side effect by anticancer agent caused by disease of the Rhizoma Phragmitis extract as active ingredient |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1483425A (en) * | 2002-09-17 | 2004-03-24 | 黄代学 | Traditional Chinese medicine for treating cancer |
| CN102133384A (en) * | 2011-03-02 | 2011-07-27 | 青岛大学 | Ginger and dried orange peel composition, preparation method thereof and application of ginger and dried orange peel composition in preparation of attenuated synergistic medicaments in cancer radiotherapy and chemotherapy |
-
2012
- 2012-04-16 CN CN2012101211458A patent/CN103239636A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1483425A (en) * | 2002-09-17 | 2004-03-24 | 黄代学 | Traditional Chinese medicine for treating cancer |
| CN102133384A (en) * | 2011-03-02 | 2011-07-27 | 青岛大学 | Ginger and dried orange peel composition, preparation method thereof and application of ginger and dried orange peel composition in preparation of attenuated synergistic medicaments in cancer radiotherapy and chemotherapy |
Non-Patent Citations (3)
| Title |
|---|
| 刘登湘等: "中西医结合治疗化疗引起的消化道反应40例疗效观察", <<第八届全国中西医结合肿瘤学术会议论文集>> * |
| 张代钊等: "中医药防治研究放化疗毒副反应40年", <<中国自然医学杂志>> * |
| 杨玉玲等: "姜辣素辅助昂丹司琼对顺铂所致大鼠异嗜行为的抑制作用", <<世界华人消化杂志>> * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103919819A (en) * | 2014-04-21 | 2014-07-16 | 青岛中仁药业有限公司 | Poria cocos natural composition and anti-cancer vomit-preventing application thereof |
| CN108697753A (en) * | 2016-02-18 | 2018-10-23 | 韩国韩医学研究院 | Contain composition for prevent, improve or treat side effect by anticancer agent caused by disease of the Rhizoma Phragmitis extract as active ingredient |
| EP3417869A4 (en) * | 2016-02-18 | 2019-10-09 | Korea Institute of Oriental Medicine | Composition containing phragmitis rhizoma extract as active ingredient for preventing, ameliorating, or treating disease attributed to side effect of anticancer agent |
| CN105616442A (en) * | 2016-03-04 | 2016-06-01 | 青岛黄海学院 | Medicine composition for treating vomit and preparation method and application of medicine composition |
| CN106377748A (en) * | 2016-11-22 | 2017-02-08 | 青岛大学 | Pharmaceutical composition for relieving emesis and inhibiting cancer as well as preparation method and application of pharmaceutical composition |
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Application publication date: 20130814 |