CN105616442A - Medicine composition for treating vomit and preparation method and application of medicine composition - Google Patents
Medicine composition for treating vomit and preparation method and application of medicine composition Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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Abstract
The invention discloses a medicine composition for treating vomit and a preparation method and application of the medicine composition. The medicine composition is prepared from humus flava usta and gingerol at the ratio of (1-10):3 by weight. The novel medicine composition for treating vomit is low in preparing toxicity and is very good in vomit stopping application.
Description
Technical field
The invention belongs to natural drug composition technical field, it is specifically related to a kind of natural drug composition treating vomiting, and the Preparation method and use of this natural drug composition.
Background technology
Vomiting is clinical common sympton, gastrointestinal illness, cancer chemicotherapy, disease of brain, vertigo, maritime vomiting, gestation etc. can cause nausea and vomiting, nausea and vomiting as caused in cancer chemotherapy process is difficult to stand most, anticancer chemistry medicine can cause 90% patient along platinum and strongly vomits, and is one of the reason of cancer patients's abandoning cure. Vomit acutely and frequently and can cause malnutrition, the de-complication such as water and rock-soil coupling and acid base imbalance. Vomiting of pregnancy can cause fetal anomaly such as applied chemistry medicine, illustrates that chemistry antiemetic toxic side effect is bigger.
At present, clinical conventional antiemetic mainly contains 5-hydroxytryptamine receptor (5-HT) antagonist (ondansetron), bradykinin (NK1) chemicals such as receptor antagonist (aprepitant), metoclopramide (Reglan), suprarenal gland glucocorticosteroid (dexamethasone), though these medicines have antiemetic effect, but toxic side effect is bigger, only tell spectrum narrow, therefore often adopt drug combination only to tell scope and drug effect to strengthen. Therefore, the initiative of urgently a kind of new type natural, low poison, wide spectrum antiemetic.
Summary of the invention
It is an object of the invention to overcome antiemetic in prior art mostly be chemical compound, only tell the shortcomings such as spectrum is narrow, toxic side effect is big, formulate a kind of low poison and only tell natural drug composition efficiently. The present invention provides preparation method and the application of aforementioned pharmaceutical compositions simultaneously.
The technology used in the present invention solution is:
Treating a pharmaceutical composition for vomiting, it is made up of Terra Flava Usta and gingerol, and the weight ratio of Terra Flava Usta and gingerol is 1-10: 3.
The preparation method of above-mentioned antiemetic composition, comprises the following steps:
(1) preparation of gingerol: nature of being cut into slices by ginger dries, powder is broken into pulverizer, cross 30 order sieves, the fine powder that will sieve puts into port grinding bottle, adds acetone soak at room temperature, then supersound extraction, centrifugal obtain supernatant liquor, by supernatant liquor decompress filter, filtrate is placed in Rotary Evaporators vacuum concentration and obtains ginger oily mixture, then by ginger oily mixture through concentrated, the dry and obtained gingerol of purifying;
(2) taking the gingerol that Terra Flava Usta and step (1) are obtained, the weight ratio of Terra Flava Usta and gingerol is 1-10: 3; Terra Flava Usta after weighing is mixed with gingerol and starch, Magnesium Stearate, obtain mixture one, then mixture one is filled in Capsules, make capsule, wherein the consumption of starch accounts for the 78%-80% of mixture one gross weight, and the consumption of Magnesium Stearate accounts for the 1%-2% of mixture one gross weight; Maybe the Terra Flava Usta after weighing is mixed with gingerol and starch, lactose, obtain mixture two, then mixture two is carried out wet granulation, drying, again with Magnesium Stearate mixed pressuring plate, make tablet, wherein the consumption of starch accounts for the 58%-60% of mixture two gross weight, and the consumption of lactose accounts for the 20% of mixture two gross weight, and the consumption of Magnesium Stearate accounts for the 1%-2% of mixture two gross weight.
Preferably, in step (1): acetone consumption is 6 times of fine powder weight of sieving; Soak time is 68-75 hour.
Preferably, in step (1): supersound extraction temperature is 40 DEG C, ultrasonic frequency is 40KHz, and the supersound extraction time is 15-20 minute.
Above-mentioned pharmaceutical composition can prepare application in emesis medicine.
The instructions of taking of the natural drug composition of above-mentioned treatment vomiting: select capsule or tablet, 1.5g for each person every day during treatment vomiting, point three one after each meals.
Compared with prior art, the Advantageous Effects of the present invention is:
Pharmaceutical composition of the present invention refers to the Terra Flava Usta that Chinese tradition medicine mineral are originated and the gingerol of plant origin, and two kinds of components are Nantural non-toxic preparation, prepare according to a certain ratio, and its emesis spectrum is wide, and antiemetic effect is remarkable.
China's mineral drug Terra Flava Usta (FurnaceSoil), another name stove cubsoil, begins to be loaded in " Mingyi Bielu ", is classified as top grade, it is the sallow soil burning weeds with having refined for a long time through fire in the native stove of firewood, in weakly alkaline, the pungent tepor of taste, nontoxic, can normalizing the stomach by guiding QI downward, warming middle-JIAO to stop vomiting. Recording in " 101 choosing side ": grind carefully with stove cubsoil, rice drink takes controls gastric disorder causing nausea vomiting; Recording in " book on Chinese herbal medicine covers bamboo fish trap ": smash carefully with stove cubsoil, water transfer clothes control vomiting of pregnancy; " book on Chinese herbal medicine is just read " is referred to as " panacea of vomitting ", with famous only to tell Chinese medicine ginger equally celebrated for their achievements.
Herbal medicine ginger (Zingiber), taste is pungent, tepor, SUN Si miao " standby anxious Qianjin Yao Fang volume 16 vomiting hiccup ": " all habitual vomiter's many foods gingers, this is a panacea of vomitting ". Gingerol (Gingerol) is the active ingredient extracted from ginger, and contriver has proved that gingerol has good emesis effect; Gingerol can act on the maximally related NK of emesis of chemotherapy1And 5-HT3Deng acceptor, it is the antiemetic of a kind of poison natural, low, existing related invention patent 10 remainder, but it is still undesirable that the standby drug effect of its unitary system vomits disease antiemetic effect in some type, and lower than part chemicals, for reaching stronger antiemetic effect, expand and only tell spectrum, reduce toxic side effects, urgently a kind of new type natural pharmaceutical composition of initiative.
Terra Flava Usta emesis has more than one thousand years application history, this medicine is had description by history tree book more, relatively it is applicable to vomiting of pregnancy, ginger is also conventional edible materials among the people, the two all can only be told, all kinds of special prescription of Chinese herbal medicine containing Terra Flava Usta disclosed in prior art and only tell in formula containing ginger, prepare in order to only to tell there are no by the combination of Terra Flava Usta and gingerol, the present invention is by concentrating on studies for many years to Terra Flava Usta and Rhizoma Zingiberis Recens extract gingerol, find a kind of optimum proportioning, the Terra Flava Usta of preparation and gingerol natural drug composition (hereinafter referred to as volt ginger composition) obtain unexpected antiemetic effect, and toxic side effect is little. this invention is the unique innovation of field of medicaments both at home and abroad at present, and its technique and proportioning are also original creation, and this only tells preparation poison natural, low, the wide spectrum of new drug, has very big using value clinical. said composition for clinical 10 example vomiting of pregnancy volunteers, achieves good antiemetic effect. the present invention intends adopting three kinds of different animal vomiting models, proves that the initiative of this volt ginger composition has wide spectrum emesis effect, and toxicity is lower.
Embodiment
The natural drug composition and preparation method that the present invention relates to is set forth further, and it is as emesis pharmaceutical use and associated beneficial effect below by specific embodiment and test example.
Embodiment 1
Group part of the natural drug composition of the treatment vomiting that the present embodiment relates to is made up of Terra Flava Usta and gingerol, and the weight ratio of Terra Flava Usta and gingerol is 1: 1.
Its preparation method specifically comprises following processing step:
(1) preparation of gingerol: nature of being cut into slices by ginger dries, powder is broken into high speed Universalpulverizer, cross 30 order sieves, the fine powder that will sieve again puts into 5000 milliliters of big port grinding bottles, soak at room temperature 68 hours in the acetone of weight 6 times, then 40 DEG C, supersound extraction 20 minutes under the ultrasonic frequency of 40KHz, centrifugal obtain supernatant liquor after residue is abandoned, again by supernatant liquor decompress filter, filtrate is placed in Rotary Evaporators vacuum concentration and obtains ginger oily mixture, by this mixture through repeatedly concentrated, the dry and obtained gingerol of purifying, for subsequent use;
(2) taking the gingerol that Terra Flava Usta and step (1) are obtained, the weight ratio of Terra Flava Usta and gingerol is 1: 3; Terra Flava Usta after weighing is mixed with gingerol and starch, Magnesium Stearate, obtain mixture one, then mixture one is filled in Capsules, makes capsule, wherein the consumption of starch accounts for the 78% of mixture one gross weight, and the consumption of Magnesium Stearate accounts for the 2% of mixture one gross weight. Each capsule is pure heavy 250 milligrams or 500 milligrams.
Embodiment 2
Group part of the natural drug composition of the treatment vomiting that the present embodiment relates to is made up of Terra Flava Usta and gingerol, and the weight ratio of Terra Flava Usta and gingerol is 2: 3.
Its preparation method specifically comprises following processing step:
(1) preparation of gingerol: nature of being cut into slices by ginger dries, powder is broken into high speed Universalpulverizer, cross 30 order sieves, the fine powder that will sieve again puts into 5000 milliliters of big port grinding bottles, soak at room temperature 75 hours in the acetone of weight 6 times, then 40 DEG C, supersound extraction 15 minutes under the ultrasonic frequency of 40KHz, centrifugal obtain supernatant liquor after residue is abandoned, again by supernatant liquor decompress filter, filtrate is placed in Rotary Evaporators vacuum concentration and obtains ginger oily mixture, by this mixture through repeatedly concentrated, the dry and obtained gingerol of purifying, for subsequent use;
(2) taking the gingerol that Terra Flava Usta and step (1) are obtained, the weight ratio of Terra Flava Usta and gingerol is 10: 3; Terra Flava Usta after weighing is mixed with gingerol and starch, lactose, obtain mixture two, then mixture two is carried out wet granulation, drying, again with Magnesium Stearate mixed pressuring plate, make tablet, wherein the consumption of starch accounts for the 60% of mixture two gross weight, and the consumption of lactose accounts for the 20% of mixture two gross weight, and the consumption of Magnesium Stearate accounts for the 1% of mixture two gross weight. Every sheet tablet is pure heavy 250 milligrams or 500 milligrams.
Embodiment 3
Group part of the natural drug composition of the treatment vomiting that the present embodiment relates to is made up of Terra Flava Usta and gingerol, and the weight ratio of Terra Flava Usta and gingerol is 5: 3.
Its preparation method specifically comprises following processing step:
(1) preparation of gingerol: nature of being cut into slices by ginger dries, powder is broken into high speed Universalpulverizer, cross 30 order sieves, the fine powder that will sieve again puts into 5000 milliliters of big port grinding bottles, soak at room temperature 70 hours in the acetone of weight 6 times, then 40 DEG C, supersound extraction 18 minutes under the ultrasonic frequency of 40KHz, centrifugal obtain supernatant liquor after residue is abandoned, again by supernatant liquor decompress filter, filtrate is placed in Rotary Evaporators vacuum concentration and obtains ginger oily mixture, by this mixture through repeatedly concentrated, the dry and obtained gingerol of purifying, for subsequent use;
(2) taking the gingerol that Terra Flava Usta and step (1) are obtained, the weight ratio of Terra Flava Usta and gingerol is 5: 3; Terra Flava Usta after weighing is mixed with gingerol and starch, Magnesium Stearate, obtain mixture one, then mixture one is filled in Capsules, makes capsule, wherein the consumption of starch accounts for the 80% of mixture one gross weight, and the consumption of Magnesium Stearate accounts for the 1% of mixture one gross weight. Each capsule is pure heavy 250 milligrams or 500 milligrams.
Embodiment 4
Group part of the natural drug composition of the treatment vomiting that the present embodiment relates to is made up of Terra Flava Usta and gingerol, and the weight ratio of Terra Flava Usta and gingerol is 1: 3.
Its preparation method specifically comprises following processing step:
(1) preparation of gingerol: nature of being cut into slices by ginger dries, powder is broken into high speed Universalpulverizer, cross 30 order sieves, the fine powder that will sieve again puts into 5000 milliliters of big port grinding bottles, soak at room temperature 72 hours in the acetone of weight 6 times, then 40 DEG C, supersound extraction 15 minutes under the ultrasonic frequency of 40KHz, centrifugal obtain supernatant liquor after residue is abandoned, again by supernatant liquor decompress filter, filtrate is placed in Rotary Evaporators vacuum concentration and obtains ginger oily mixture, by this mixture through repeatedly concentrated, the dry and obtained gingerol of purifying, for subsequent use;
(2) taking the gingerol that Terra Flava Usta and step (1) are obtained, the weight ratio of Terra Flava Usta and gingerol is 7: 3; Terra Flava Usta after weighing is mixed with gingerol and starch, lactose, obtain mixture two, then mixture two is carried out wet granulation, drying, again with Magnesium Stearate mixed pressuring plate, make tablet, wherein the consumption of starch accounts for the 59% of mixture two gross weight, and the consumption of lactose accounts for the 20% of mixture two gross weight, and the consumption of Magnesium Stearate accounts for the 2% of mixture two gross weight. Every sheet tablet is pure heavy 250 milligrams or 500 milligrams.
Test example 1
This test example for conventional anticancer chemotherapy medicine along the vomiting caused by platinum, it may also be useful to the volt ginger composition of the present invention (when testing 1:1 in embodiment 1 of all illustrating herein experiment effect) carries out drug treatment, and relevant pharmacodynamic study is as follows:
(1) experiment material: along platinum (20mg/ props up), ondansetron hydrochloride injection liquid (2ml:4mg), healthy adult mink (male, body weight 1.3-1.8kg), every mink is placed in separately the iron cage of 75cm �� 50cm �� 50cm, 24 hours natural light irradiations, drinking-water of freely taking food before experiment;
(2) experimental technique: mink is divided into 4 groups at random, often organizes 6, and A group is that B group is ondansetron positive drug group, and C group is gingerol group along platinum model control group, and D group is volt ginger composition group; A group gives physiological saline pre-treatment, and B group gives ondansetron 7.5mg kg-1Pre-treatment, C group gives gingerol 10g kg-1(being equivalent to containing crude drug amount) gavage (ig) pre-treatment, D group gives volt ginger composition 10g kg-1(being equivalent to containing crude drug amount) ig pre-treatment, each group all gives after 30 minutes along platinum 7.5mg kg in administration-1Ip, observes the mink vomiting reaction in 6 hours upon administration, records it and vomits latent period, retch number of times and vomiting number of times;
(3) experimental result: compare with control group, each treatment group all can alleviate retch number of times and vomit number of times and extend vomiting latent period (P 0.01), wherein D group volt ginger composition group can effectively reduce the rate of vomitting that causes (P 0.01), and comparing result is as shown in table 1:
Table 1 volt ginger composition is to along platinum (7.5mg kg-1Ip) cause vomit effect impact (N=6)
Note: a is equivalent to compare P containing crude drug amount with control groupc0.01
Test example 2
The vomiting that this test example causes for copper sulfate, it may also be useful to the volt ginger composition of the present invention carries out drug treatment, relevant pharmacodynamic study is as follows:
(1) experiment material: copper sulfate, ondansetron hydrochloride injection liquid (2ml:4mg), healthy adult mink (male, body weight 1.3-1.8kg), every mink is placed in separately the iron cage of 75cm �� 50cm �� 50cm, 24 hours natural light irradiations, drinking-water of freely taking food before experiment;
(2) experimental technique: mink is divided into 4 groups at random, often organizes 6, and A group is copper sulfate model control group, and B group is ondansetron positive drug group, and C group is gingerol group, and D group is volt ginger composition group; A group gives physiological saline pre-treatment, and B group gives ondansetron 7.5mg kg-1Pre-treatment, C group gives gingerol 10g kg-1(being equivalent to containing crude drug amount) ig pre-treatment, D group gives volt ginger composition 10g kg-1(being equivalent to containing crude drug amount) ig pre-treatment, each group all gives after 30 minutes along platinum 7.5mg kg in administration-1Ip, observes the mink vomiting reaction in 6 hours upon administration, records it and vomits latent period, retch number of times and vomiting number of times;
(3) experimental result: compare with control group, each treatment group all can alleviate retch number of times and vomit number of times and extend vomiting latent period (P 0.01), wherein D group volt ginger composition group emesis effect is better than C group gingerol group (P 0.01), and comparing result is as shown in table 2:
Table 2 volt ginger composition is to copper sulfate (40mg kg-1) cause vomit effect impact (N=6)
Note: a is equivalent to compare P containing crude drug amount with control groupc0.01.
Test example 3
The vomiting that this test example causes for Apomorphine, it may also be useful to the volt ginger composition of the present invention carries out drug treatment, relevant pharmacodynamic study is as follows:
(1) experiment material: Apomorphine, ondansetron hydrochloride injection liquid (2ml:4mg), healthy adult mink (male, body weight 1.3-1.8kg), every mink is placed in separately the iron cage of 75cm �� 50cm �� 50cm, 24 hours natural light irradiations, drinking-water of freely taking food before experiment;
(2) experimental technique: mink is divided into 4 groups at random, often organizes 6, and A group is Apomorphine model control group, and B group is ondansetron positive drug group, and C group is gingerol group, and D group is volt ginger composition group; A group gives physiological saline pre-treatment, and B group gives ondansetron 7.5mg kg-1Pre-treatment, C group gives gingerol 10g kg-1(being equivalent to containing crude drug amount) ig pre-treatment, D group gives volt ginger composition 10g kg-1(being equivalent to containing crude drug amount) ig pre-treatment, each group all gives Apomorphine 0.25mg kg in administration after 30 minutes-1Ip, observes the mink vomiting reaction in 2 hours upon administration, records it and vomits latent period, retch number of times and vomiting number of times;
(3) experimental result: compare with control group, each treatment group all can alleviate retch number of times and vomit number of times and extend vomiting latent period (P 0.01), wherein D group volt ginger composition group emesis effect is better than C group gingerol group (P 0.01), and comparing result is as shown in table 3:
Table 3 volt ginger composition is to Apomorphine (0.25mg kg-1Ip) cause vomit effect impact (N=6)
Note: a is equivalent to compare P containing crude drug amount with control groupc0.01.
Test example 4
This test example carries out acute toxicity test for volt ginger composition, and relevant data are as follows:
(1) experimental animal: Kunming mouse (body weight 20 �� 2g), is provided by medicine inspecting institute of Qingdao City Experimental Animal Center;
(2) medicine: the volt ginger composition of the present invention;
(3) test method: " the study of tcm new drug technical requirements " promulgating revision according to National Drug Administration on November 12nd, 1999, the volt ginger composition of the present invention is carried out acute toxicity test, because by drug level and volumetric constraint, LD cannot be measured50, therefore carry out maximum dosage-feeding test; Get Kunming mouse 30, male and female half and half, give the capsule medicine 1g/ml of preparation in embodiment 1, every 0.8ml, the i.e. maximum gavage volume of mouse, by observation post administration mouse active state, diet, ight soil, breathing, body weight and death condition, observe 14 days continuously, the relevant data of record;
(4) test-results: well-grown after the mouse stomach administration of each group, body weight increases, and behavior is normal, is showed no death and significant reaction, after sacrifice, each main organs of visual inspection phenomenon without exception.
Result proves, the volt ginger composition maximal dose oral application of preparation involved in the present invention, to animal without obvious damage, does not find body is produced toxic reaction, is a kind of safe and reliable emesis natural composition.
Claims (5)
1. treat the pharmaceutical composition of vomiting for one kind, it is characterised in that: this pharmaceutical composition is made up of Terra Flava Usta and gingerol, and the weight ratio of Terra Flava Usta and gingerol is 1-10: 3.
2. the preparation method of a kind of pharmaceutical composition treating vomiting as claimed in claim 1, it is characterised in that comprise the following steps:
(1) preparation of gingerol: nature of being cut into slices by ginger dries, powder is broken into pulverizer, cross 30 order sieves, the fine powder that will sieve puts into port grinding bottle, adds acetone soak at room temperature, then supersound extraction, centrifugal obtain supernatant liquor, by supernatant liquor decompress filter, filtrate is placed in Rotary Evaporators vacuum concentration and obtains ginger oily mixture, then by ginger oily mixture through concentrated, the dry and obtained gingerol of purifying;
(2) taking the gingerol that Terra Flava Usta and step (1) are obtained, the weight ratio of Terra Flava Usta and gingerol is 1-10: 3; Terra Flava Usta after weighing is mixed with gingerol and starch, Magnesium Stearate, obtain mixture one, then mixture one is filled in Capsules, make capsule, wherein the consumption of starch accounts for the 78%-80% of mixture one gross weight, and the consumption of Magnesium Stearate accounts for the 1%-2% of mixture one gross weight; Maybe the Terra Flava Usta after weighing is mixed with gingerol and starch, lactose, obtain mixture two, then mixture two is carried out wet granulation, drying, again with Magnesium Stearate mixed pressuring plate, make tablet, wherein the consumption of starch accounts for the 58%-60% of mixture two gross weight, and the consumption of lactose accounts for the 20% of mixture two gross weight, and the consumption of Magnesium Stearate accounts for the 1%-2% of mixture two gross weight.
3. the preparation method of a kind of pharmaceutical composition treating vomiting according to claim 2, it is characterised in that, in step (1): acetone consumption is 6 times of fine powder weight of sieving; Soak time is 68-75 hour.
4. the preparation method of a kind of pharmaceutical composition treating vomiting according to claim 2, it is characterised in that, in step (1): supersound extraction temperature is 40 DEG C, ultrasonic frequency is 40KHz, and the supersound extraction time is 15-20 minute.
5. pharmaceutical composition as claimed in claim 1 is in the application prepared in emesis medicine.
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| WO2003045411A2 (en) * | 2001-11-26 | 2003-06-05 | Finzelberg Gmbh & Co. Kg | Ginger extract preparation |
| CN102552453A (en) * | 2012-02-10 | 2012-07-11 | 威海华新药业集团有限公司 | Application of gingerol and rhizoma coptidis composition to preparation of medicine for resisting vomiting |
| CN102743736A (en) * | 2012-07-13 | 2012-10-24 | 宗有莲 | Medicament for treating hyperemesis gravidarum |
| CN102908606A (en) * | 2012-11-17 | 2013-02-06 | 刘锋 | Traditional Chinese medicine for treating pregnancy vomiting |
| CN103239636A (en) * | 2012-02-08 | 2013-08-14 | 岳晓 | Application of reed rhizome extract and gingerol in preparation of attenuated synergistic medicines for cancer chemotherapy |
| CN104000876A (en) * | 2014-06-18 | 2014-08-27 | 青岛市市立医院 | Composition of mangnolia officinalis and gingerol and application thereof |
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2016
- 2016-03-04 CN CN201610124932.6A patent/CN105616442A/en active Pending
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|---|---|---|---|---|
| WO2003045411A2 (en) * | 2001-11-26 | 2003-06-05 | Finzelberg Gmbh & Co. Kg | Ginger extract preparation |
| CN103239636A (en) * | 2012-02-08 | 2013-08-14 | 岳晓 | Application of reed rhizome extract and gingerol in preparation of attenuated synergistic medicines for cancer chemotherapy |
| CN102552453A (en) * | 2012-02-10 | 2012-07-11 | 威海华新药业集团有限公司 | Application of gingerol and rhizoma coptidis composition to preparation of medicine for resisting vomiting |
| CN102743736A (en) * | 2012-07-13 | 2012-10-24 | 宗有莲 | Medicament for treating hyperemesis gravidarum |
| CN102908606A (en) * | 2012-11-17 | 2013-02-06 | 刘锋 | Traditional Chinese medicine for treating pregnancy vomiting |
| CN104000876A (en) * | 2014-06-18 | 2014-08-27 | 青岛市市立医院 | Composition of mangnolia officinalis and gingerol and application thereof |
Non-Patent Citations (1)
| Title |
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| 徐治国等: "《中药学》", 31 October 1991 * |
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Application publication date: 20160601 |