CN101708241A - Medicinal composition for eliminating dampness and relieving itching - Google Patents
Medicinal composition for eliminating dampness and relieving itching Download PDFInfo
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- CN101708241A CN101708241A CN200910249618A CN200910249618A CN101708241A CN 101708241 A CN101708241 A CN 101708241A CN 200910249618 A CN200910249618 A CN 200910249618A CN 200910249618 A CN200910249618 A CN 200910249618A CN 101708241 A CN101708241 A CN 101708241A
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- fructus kochiae
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- sophorae flavescentis
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Abstract
The invention relates to the field of medicaments, in particular to a medicinal composition for treating eczema. The medicinal composition of the invention is prepared by processing the following raw materials of traditional medicinal herbs: fructus kochiae, tree peony bark, kuh-seng, densefruit pittany root-bark and unripe liquorice.
Description
Technical field
The present invention relates to the Chinese medicine drug world, particularly a kind of pharmaceutical composition for the treatment of eczema.
Technical background
Eczema (Eczema) is a kind of common inflammation disease, more with the erythra form, be easy to ooze out, course of disease delay and tendency of recurrence is arranged is feature, pilosity is born in child and teenager, clinical manifestation is multirow, erythema, little pimple arranged, fester, ooze out, plumpness etc., can occur separately, also can two or morely exist simultaneously.Eczema can be divided into acute eczema, subacute eczema, chronic eczema by outbreak stage and symptom, the three does not have absolute obvious limit, its pathogenic factor complexity is difficult to determine more, the delayed allergy that multiple often inside and outside factor interaction causes, it is relevant with the allergic diathesis of body, neural Nervous and Mental Factors, allergy allergy etc. to fall ill.
The present compound Chinese medicinal preparation of some removing dampness to relieve itching of listing, some belongs to cures the symptoms, not the disease, and some uses expensive composition, and some is on stream because uncertain therapeutic efficacy is cut interrupts developing.
Clinical treatment shortage specific medicament, and dosage form at present is many to bring certain trouble based on external to practical application, and urgent clinical needs are efficient, the endo-medicine of low toxicity addresses this problem.
We with the dampness heat clearing away and in antipruritic be the rule of treatment, select for use the Chinese medicine of the five flavours raw material to make pharmaceutical preparation, the various acute and chronic eczemas of described preparation for treating, clinical acquisition satisfactory effect.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine pharmaceutical composition for the treatment of eczema.
Pharmaceutical composition of the present invention is processed into by following raw material of Chinese medicine process: the Fructus Kochiae, Cortex Moutan, Radix Sophorae Flavescentis, Cortex Dictamni and Radix Glycyrrhizae.
Compositions of the present invention is processed into by following raw material of Chinese medicine process:
Fructus Kochiae 250-2250g Cortex Moutan 167-1500g Radix Sophorae Flavescentis 150-1350g
Cortex Dictamni 133-1200g Radix Glycyrrhizae 100-900g
Preferred compositions of the present invention is processed into by following raw material of Chinese medicine process:
Fructus Kochiae 375-1500g Cortex Moutan 250-1000g Radix Sophorae Flavescentis 225-900g
Cortex Dictamni 200-800g Radix Glycyrrhizae 150-600g
Further preferred compositions of the present invention is processed into by following raw material of Chinese medicine process:
Fructus Kochiae 750g Cortex Moutan 500g Radix Sophorae Flavescentis 450g
Cortex Dictamni 400g Radix Glycyrrhizae 300g
Above Chinese medicinal raw materials, weight is calculated with the medical material amount, the medical material of above weight, can be made into 1000 agent medicine preparations through refining to be processed into, described 1000 agent formulations are meant: can be made into 1000 doses of the Chinese medicine preparation of different dosage form, and as 1000 in tablet, 1000 of capsules, granule 1000g, pill 1000 balls etc.
The ratio of above weight proportion obtains through science screening, for especial patient, and as serious symptom or light disease, fat or modest patient, the proportioning of the amount of can corresponding adjustment forming increases or reduces being no more than 300%, and drug effect is constant.
Single medicinal material, especially ministerial drug and adjuvant drug in more than forming also can be replaced by the suitable Chinese medicine with identical property of medicine, and its drug effect of the Chinese medicine preparation after the replacement is constant.
Chinese medicine composition of the present invention is to process through extraction or other modes by the raw material of Chinese medicine that above-mentioned prescription is formed, and makes pharmaceutically active substance, subsequently, with this material is raw material, adds the medicine acceptable carrier when needing, and makes according to the routine techniques of galenic pharmacy.Described active substance can obtain by extracting raw material of Chinese medicine respectively, also can obtain by the co-extracted raw material of Chinese medicine, also can obtain by other modes, as: by pulverize, squeeze, calcine, grind, sieve, percolation, extraction, water are carried, alcohol extraction, ester are carried, methods such as ketone is carried, chromatography obtain, these active substances can be the material of extractum form, can be that dry extract also can be a fluid extract, make different concentration according to the different needs decision of preparation.
Pharmaceutically active substance in the Chinese medicine composition of the present invention, its shared percentage by weight in preparation can be 0.1-99.9%, all the other are the medicine acceptable carrier.Pharmaceutical composition of the present invention exists with unit dosage form, and described unit dosage form is meant the unit of preparation, as every of tablet, and capsular every capsules, every bottle of oral liquid, every bag of granule etc.
Chinese medicine composition of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, peroral dosage form preferably, as: capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum etc.
Chinese medicine composition of the present invention, the preparation of its oral administration can contain excipient commonly used, such as binding agent, filler, diluent, tablet agent, lubricant, disintegrating agent, coloring agent, flavoring agent and wetting agent, can carry out coating to tablet in case of necessity.
The filler that is suitable for comprises cellulose, mannitol, lactose and other similar filler.Suitable disintegrating agent comprises starch, polyvinylpyrrolidone and starch derivatives, for example sodium starch glycollate.Suitable lubricant comprises, for example magnesium stearate.The acceptable wetting agent of appropriate drug comprises sodium lauryl sulphate.
Can fill by mixing, the method that tabletting etc. are commonly used prepares solid oral composition.Mix repeatedly active substance is distributed in those compositionss of a large amount of filleies of whole use.
The form of oral liquid for example can be aqueous or oily suspensions, solution, Emulsion, syrup or elixir, perhaps can be a kind of available water before use or other suitable composite dry products of carrier.This liquid preparation can contain conventional additive, such as suspending agent, for example sorbitol, syrup, methylcellulose, gelatin, hydroxyethyl-cellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenation edible fat, emulsifying agent, for example lecithin, anhydro sorbitol monooleate or arabic gum; Non-aqueous carrier (they can comprise edible oil), for example almond oil, fractionated coconut oil, such as oily ester, propylene glycol or the ethanol of the ester of glycerol; Antiseptic, for example para hydroxybenzene methyl ester or propyl p-hydroxybenzoate or sorbic acid, and if desired, can contain conventional flavouring agent or coloring agent.
For injection, the liquid unit dosage forms of preparation contains active substance of the present invention and sterile carrier.According to carrier and concentration, this chemical compound can be suspended or dissolving.The preparation of solution is normally by being dissolved in active substance in a kind of carrier filter-sterilized before it is packed into a kind of suitable bottle or ampoule, sealing then.For example a kind of local anesthetic of adjuvant, antiseptic and buffer agent also can be dissolved in this carrier.In order to improve its stability, can be after the bottle of packing into that this compositions is freezing, and under vacuum, water is removed.
Chinese medicine composition of the present invention, when being prepared into medicament, optionally add suitable medicine acceptable carrier, described medicine acceptable carrier is selected from: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, the EDTA disodium, EDTA calcium sodium, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, the phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Another object of the present invention is to provide a kind of preparation method of Chinese medicine composition of the present invention.
It is as follows that the preparation method of Chinese medicine composition of the present invention has step:
The Fructus Kochiae adds alcohol reflux, and extracting solution concentrates; Get residue and add other 4 flavor Chinese medicines, decoct with water, filter, filtrate and alcohol extraction concentrated solution, medicinal liquid concentrates, and drying is made pharmaceutically active substance, is prepared into pharmaceutical preparation according to the galenic pharmacy routine techniques again.
The preparation method of preferred Chinese medicine composition of the present invention:
(1) Fructus Kochiae adds 50-90% alcohol reflux 2-4 time, and each 0.5-2 hour, merge extractive liquid, is concentrated into did not have the alcohol flavor;
(2) get residue and add Cortex Moutan, Radix Sophorae Flavescentis, Cortex Dictamni and Radix Glycyrrhizae 4 flavor Chinese medicines decoct with water each 0.5-2 hour 2-4 time, collecting decoction, filter, filtrate and the merging of alcohol extraction concentrated solution stir, and medicinal liquid is concentrated into relative density and is about 1.0-2.0 (50 ℃), drying under reduced pressure is made pharmaceutically active substance and is prepared into 1000 doses of pharmaceutical preparatioies according to the galenic pharmacy routine techniques again.
The preparation method of further preferred Chinese medicine composition of the present invention:
(1) Fructus Kochiae adds 70% alcohol reflux 2 times, adds 10 times, 8 times amount 70% ethanol respectively, and each 1 hour, merge extractive liquid, is concentrated into did not have the alcohol flavor;
(2) get Fructus Kochiae residue and add Cortex Moutan, Radix Sophorae Flavescentis, Cortex Dictamni and Radix Glycyrrhizae 4 flavor Chinese medicines, decoct with water twice, each 1 hour, collecting decoction, filter, filtrate and the merging of alcohol extraction concentrated solution stir, and medicinal liquid is concentrated into relative density and is about 1.3 (50 ℃), 70 degree drying under reduced pressure are pulverized, and add dextrin and steviosin, make granule, drying is made 1000g, promptly.
By following test, further prove beneficial effect of the present invention:
We select following experiment and observation index, further its curative effect of evaluation of science in conjunction with clinical rule of treatment method of treatment:
(1) the removing dampness to relieve itching granule is to the therapeutical effect of Eczema Model:
1. to the therapeutical effect of Guinea Pig Eczema Model:
Get 4～5 age in week the Healthy female Cavia porcellus, every guinea pig back both sides unhairing, shaving intradermal injection OVA (chicken ovalbumin) the 10 μ g+Al (OH) of hair place
30.5mg; After 1 week,, coat 10%OVA+10%SDS (granule of the embodiment of the invention 1)+30% vaseline+50% water, be affixed on and shave hair place maintenance 48h with 3cm * 4cm gauze; In the 3rd week after the intradermal injection, reuse 3cm * 4cm gauze coats 10%OVA+5%SDS+37% vaseline+48% water, is affixed on to shave hair place maintenance 48h; Had a rest for 1 week,, coat 10%OVA+20% water+70% vaseline, be affixed on and shave hair place maintenance 24h, do the antigen stimulation reaction with 1cm * 1cm double gauze.Behind the 48h erythema, edema, scratch are marked, calculate total points.
The result shows that pharmaceutical composition of the present invention can effectively reduce the erythema area, alleviate edema and scratch degree, effectively treats Guinea Pig Eczema.
(2) antiinflammatory action experiment:
1. the scorching test of Mice Auricle caused by dimethylbenzene xylene
The mice last is given behind the granule of the embodiment of the invention 1 30 minutes, dimethylbenzene 50ul dripped the two sides causes inflammation before and after the mouse right ear, put to death mice after 1 hour, punch in mice left and right sides ears same area with card punch, and the weight of dividing another name both sides auricle, difference with two auricle weight is the swelling degree, calculates and respectively organizes the swelling degree, and obtain inhibitory rate of intumesce.
The result shows that pharmaceutical composition of the present invention can effectively reduce mice auricle swelling degree and inhibitory rate of intumesce.
2. to the therapeutical effect of rat paw edema inflammation:
Give the rat last with behind the granule of the embodiment of the invention 11 hour, right back sufficient plantar subcutaneous injection 25% fresh albumen 0.05ml/ only is administered once simultaneously again, measures the right back sufficient volume that causes scorching back different time sections then.
The result shows that pharmaceutical composition of the present invention can effectively reduce the rat paw edema degree.
(3) antipruritic experiment:
After the right back instep cropping with albino guinea-pig, irritate the granule of stomach normal saline, the embodiment of the invention 1, drip 0.01% histamine phosphate, 50 μ l/ pawls behind the 1h at each position, be 0.02% every 3min dripping again with the position that concentration increases progressively later on, 0.03%, the histamine phosphate of 0.04% equivalent, till foot appearred licking in Cavia porcellus, giving the total amount of the histamine phosphate that each animal dripped in the period with this section was itch-threshold.
The result shows that pharmaceutical composition of the present invention can effectively reduce the Cavia porcellus itch-threshold, has itching-relieving action preferably.
(4) bacteriostatic experiment:
Depletion Staphylococcus aureus before the test, escherichia coli, salmonella, fresh strain inclined plane such as Candida albicans, be seeded in nutrient broth medium and the improvement Martin culture medium, after preference temperature is cultivated suitable time, be diluted to suitable concentration with normal saline, measure viable count, granule with the corresponding culture medium dilution embodiment of the invention 1, be respectively charged into each 1ml of every pipe, get suitable dilution level bacterium liquid in each bacteriostatic test pipe, inoculation shakes up, test organisms is fully contacted with medicinal liquid, put in the incubator and cultivate, viewing test bacteria growing situation, the lowest concentration of drug of not growing with antibacterial is the minimum inhibitory concentration of this medicine.
The result shows that pharmaceutical composition of the present invention has good inhibitory effect to staphylococcus aureus, escherichia coli, salmonella, Candida albicans.
(5) to the influence of mice vascular permeability
Give behind the granule of the embodiment of the invention 11 hour with the mice last, the blue normal saline tail vein injection of ivens to animal body, after the execution is shredded skin, put into 7: 3 acetone normal saline and soaked 48 hours, absorbance is measured in centrifugal back.
The result shows that pharmaceutical composition of the present invention can increase capillary permeability.
(6) acute toxicity testing
By acute toxicity testing, the granule of the embodiment of the invention 1 is safe.
The pharmaceutical composition that uses in the above-mentioned test is the granule of the embodiment of the invention 1, and the pharmaceutical preparation of the present invention that other prescriptions are formed also has identical or akin effect.
The present invention also comprises, the application of pharmaceutical composition of the present invention in the medicine of preparation treatment eczema.
In sum, pharmaceutical composition of the present invention compared with prior art, it is good to have a therapeutic effect, treatment time is short, good stability, few side effects, cost is low, preparation method is simple, is fit to characteristics such as large-scale production.
The specific embodiment:
By following examples the present invention is done step explanation, but not as restriction of the present invention.
Embodiment 1, granule
Fructus Kochiae 750g Cortex Moutan 500g Radix Sophorae Flavescentis 450g
Cortex Dictamni 400g Radix Glycyrrhizae 300g
Method for making:
The Fructus Kochiae adds 70% alcohol reflux twice, adds 10 times of 70% ethanol, 8 times respectively, and each 1 hour, merge extractive liquid, is concentrated into did not have the alcohol flavor; Get residue and add other 4 flavors, decoct with water twice, each 1 hour, collecting decoction filters, and filtrate and the merging of alcohol extraction concentrated solution stir, medicinal liquid is concentrated into relative density and is about 1.3 (50 ℃), 70 degree drying under reduced pressure are pulverized, and add dextrin and steviosin, make granule, drying is made 1000g, promptly.
Embodiment 2, pharmaceutical composition of the present invention
Fructus Kochiae 250g Cortex Moutan 167g Radix Sophorae Flavescentis 150g
Cortex Dictamni 133g Radix Glycyrrhizae 100g
Embodiment 3, pharmaceutical composition of the present invention
Fructus Kochiae 2250g Cortex Moutan 1500g Radix Sophorae Flavescentis 1350g
Cortex Dictamni 1200g Radix Glycyrrhizae 900g
Embodiment 4, pharmaceutical composition of the present invention
Fructus Kochiae 375g Cortex Moutan 250g Radix Sophorae Flavescentis 225g
Cortex Dictamni 200g Radix Glycyrrhizae 150g
Embodiment 5, pharmaceutical composition of the present invention
Fructus Kochiae 1500g Cortex Moutan 1000g Radix Sophorae Flavescentis 900g
Cortex Dictamni 800g Radix Glycyrrhizae 600g
Embodiment 6, capsule
Get any pharmaceutically active substance of embodiment 1-5, add appropriate amount of starch, sucrose and magnesium stearate are granulated, and incapsulate, and promptly get capsule.
Embodiment 7, tablet
Get any pharmaceutically active substance of embodiment 1-5, with starch, sodium carboxymethyl cellulose, Pulvis Talci mix homogeneously are granulated, and tabletting promptly gets tablet.
Embodiment 8, oral liquid
Get any pharmaceutically active substance of embodiment 1-5, with syrup, be dissolved in the pure water, homogenizing filters, through high-temperature short-time sterilization.Sterile filling, packing.Make oral liquid.
Embodiment 9, injectable powder
Get any pharmaceutically active substance of embodiment 1-5, glucose, sodium thiosulfate and distilled water, behind the said components mix homogeneously, lyophilization, packing promptly gets injectable powder.
Group component in the foregoing description and the description scope can enlarge or reduce in scale simultaneously according to producing needs.
Claims (10)
1. a pharmaceutical composition for the treatment of eczema is characterized in that, comprises that following raw material of Chinese medicine is through being processed into: the Fructus Kochiae, Cortex Moutan, Radix Sophorae Flavescentis, Cortex Dictamni and Radix Glycyrrhizae.
2. pharmaceutical composition according to claim 1 is characterized in that, described pharmaceutical composition is processed into by following raw material of Chinese medicine:
Fructus Kochiae 250-2250g Cortex Moutan 167-1500g Radix Sophorae Flavescentis 150-1350g
Cortex Dictamni 133-1200g Radix Glycyrrhizae 100-900g.
3. pharmaceutical composition according to claim 2 is characterized in that, described pharmaceutical composition is processed into by following raw material of Chinese medicine:
Fructus Kochiae 375-1500g Cortex Moutan 250-1000g Radix Sophorae Flavescentis 225-900g
Cortex Dictamni 200-800g Radix Glycyrrhizae 150-600g.
4. pharmaceutical composition according to claim 3 is characterized in that, described pharmaceutical composition is processed into by following raw material of Chinese medicine:
Fructus Kochiae 750g Cortex Moutan 500g Radix Sophorae Flavescentis 450g
Cortex Dictamni 400g Radix Glycyrrhizae 300g.
5. according to described any one compositions of claim 1-4, wherein contain pharmaceutically acceptable carrier.
6. according to described any one compositions of claim 1-4, be any pharmaceutically useful dosage form.
7. according to the application of described any one compositions of claim 1-4 in the medicine of preparation treatment eczema.
8. according to described any one preparation of drug combination method of claim 1-4, it is characterized in that preparation process is as follows:
(1) Fructus Kochiae adds alcohol reflux, and extracting solution concentrates;
(2) get residue and add other Cortex Moutan, Radix Sophorae Flavescentis, Cortex Dictamni and Radix Glycyrrhizae 4 flavor Chinese medicines decoct with water, filter, filtrate and alcohol extraction concentrated solution, medicinal liquid concentrates, and drying is made pharmaceutically active substance, is prepared into pharmaceutical preparation according to the galenic pharmacy routine techniques again.
9. preparation method according to claim 5 is characterized in that preparation process is as follows:
(1) Fructus Kochiae adds 50-90% alcohol reflux 2-4 time, and each 0.5-2 hour, merge extractive liquid, is concentrated into did not have the alcohol flavor;
(2) get residue and add Cortex Moutan, Radix Sophorae Flavescentis, Cortex Dictamni and Radix Glycyrrhizae 4 flavor Chinese medicines decoct with water 2-4 time, each 0.5-2 hour, collecting decoction filters, and filtrate and the merging of alcohol extraction concentrated solution stir, it is 1.0-2.0 that 50 ℃ of medicinal liquids are concentrated into relative density, drying under reduced pressure is made pharmaceutically active substance, is prepared into 1000 doses of pharmaceutical preparatioies according to the galenic pharmacy routine techniques again.
10. preparation method according to claim 6 is characterized in that preparation process is as follows:
(1) Fructus Kochiae adds 70% alcohol reflux 2 times, adds 10 times, 8 times amount 70% ethanol respectively, and each 1 hour, merge extractive liquid, is concentrated into did not have the alcohol flavor;
(2) get Fructus Kochiae residue and add Cortex Moutan, Radix Sophorae Flavescentis, Cortex Dictamni and Radix Glycyrrhizae 4 flavor Chinese medicines, decoct with water twice, each 1 hour, collecting decoction, filter, filtrate and the merging of alcohol extraction concentrated solution stir, and 50 ℃ of medicinal liquids are concentrated into relative density and are about 1.3,70 degree drying under reduced pressure are pulverized, and add dextrin and steviosin, make granule, drying is made 1000g, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102496180A CN101708241B (en) | 2009-12-08 | 2009-12-08 | Medicinal composition for eliminating dampness and relieving itching |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102496180A CN101708241B (en) | 2009-12-08 | 2009-12-08 | Medicinal composition for eliminating dampness and relieving itching |
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| CN101708241A true CN101708241A (en) | 2010-05-19 |
| CN101708241B CN101708241B (en) | 2012-02-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2009102496180A Expired - Fee Related CN101708241B (en) | 2009-12-08 | 2009-12-08 | Medicinal composition for eliminating dampness and relieving itching |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102058776A (en) * | 2010-12-25 | 2011-05-18 | 马建国 | Medicinal oil for treating drying type infantile eczema and preparation method thereof |
| CN102370761A (en) * | 2010-08-18 | 2012-03-14 | 上海科鑫生物工程有限公司 | Traditional Chinese medicine compound recipe used for preventing or resisting allergy, preparation method thereof, and application thereof |
| CN102716395A (en) * | 2012-06-13 | 2012-10-10 | 中国人民解放军总医院 | Traditional Chinese medicine spray for treating skin diseases |
| CN102755435A (en) * | 2012-07-12 | 2012-10-31 | 中国人民解放军第三O二医院 | Chinese medicinal preparation for treating cutaneous pruritus and preparation method thereof |
| CN102961457A (en) * | 2012-12-11 | 2013-03-13 | 青岛农业大学 | Veterinary drug used for treating eczema of pet |
| CN103690655A (en) * | 2013-11-28 | 2014-04-02 | 祝迈 | External medicine for treating infantile eczema |
| CN105250441A (en) * | 2015-10-09 | 2016-01-20 | 广州萃纳康生物科技有限公司 | Plant relieving antipruritic |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1170597A (en) * | 1997-07-09 | 1998-01-21 | 李竹岭 | Eczema pill |
| CN101181475B (en) * | 2007-11-15 | 2011-01-26 | 郭敬春 | Chinese medicine composition orally taken for curing acute eczema |
| CN101530578B (en) * | 2009-04-14 | 2011-09-07 | 路正平 | Drug for curing skin scratchness |
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2009
- 2009-12-08 CN CN2009102496180A patent/CN101708241B/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102370761A (en) * | 2010-08-18 | 2012-03-14 | 上海科鑫生物工程有限公司 | Traditional Chinese medicine compound recipe used for preventing or resisting allergy, preparation method thereof, and application thereof |
| CN102370761B (en) * | 2010-08-18 | 2013-11-06 | 上海科鑫生物工程有限公司 | Traditional Chinese medicine compound recipe used for preventing or resisting allergy, preparation method thereof, and application thereof |
| CN102058776A (en) * | 2010-12-25 | 2011-05-18 | 马建国 | Medicinal oil for treating drying type infantile eczema and preparation method thereof |
| CN102058776B (en) * | 2010-12-25 | 2012-07-04 | 马建国 | Medicinal oil for treating drying type infantile eczema and preparation method thereof |
| CN102716395A (en) * | 2012-06-13 | 2012-10-10 | 中国人民解放军总医院 | Traditional Chinese medicine spray for treating skin diseases |
| CN102716395B (en) * | 2012-06-13 | 2014-04-23 | 中国人民解放军总医院 | Traditional Chinese medicine spray for treating skin diseases |
| CN102755435A (en) * | 2012-07-12 | 2012-10-31 | 中国人民解放军第三O二医院 | Chinese medicinal preparation for treating cutaneous pruritus and preparation method thereof |
| CN102961457A (en) * | 2012-12-11 | 2013-03-13 | 青岛农业大学 | Veterinary drug used for treating eczema of pet |
| CN102961457B (en) * | 2012-12-11 | 2014-07-30 | 青岛农业大学 | Veterinary drug used for treating eczema of pet |
| CN103690655A (en) * | 2013-11-28 | 2014-04-02 | 祝迈 | External medicine for treating infantile eczema |
| CN105250441A (en) * | 2015-10-09 | 2016-01-20 | 广州萃纳康生物科技有限公司 | Plant relieving antipruritic |
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| CN101708241B (en) | 2012-02-22 |
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