CN106109564A - Pharmaceutical composition for the treatment of cerebral thrombosis and preparation method thereof - Google Patents
Pharmaceutical composition for the treatment of cerebral thrombosis and preparation method thereof Download PDFInfo
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- CN106109564A CN106109564A CN201610515685.2A CN201610515685A CN106109564A CN 106109564 A CN106109564 A CN 106109564A CN 201610515685 A CN201610515685 A CN 201610515685A CN 106109564 A CN106109564 A CN 106109564A
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- cerebral thrombosis
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- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of pharmaceutical composition treating cerebral thrombosis and preparation method thereof, pharmaceutical composition of the present invention is with Calendula arvensis L., Herba thymi vulgaris, Fructus Nandinae Domesticae, smelly arrow dish, Blatta seu periplaneta, protopine, 19 deoxidation 15 chlorine Jia Shi cyanidin as crude drug, proportioning forms, can make various dosage form by preparation process routinely, treatment cerebral thrombosis is evident in efficacy.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of pharmaceutical composition treating cerebral thrombosis and preparation side thereof
Method.
Background technology
Cerebral thrombosis is the modal type of cerebral infarction.It is cerebral arteries trunk or cortical branches atherosclerosis causes blood
Pipe thickens, luminal stenosis inaccessible and thrombosis, causes brain regional blood flow to reduce or blood supply is interrupted, and brain tissue ischemia anoxia causes
Soften necrosis and focal neurological symptom occurs.Heilungkiang News Network interrogates in recent years, suffers from people's age of cerebral thrombosis constantly
Reducing, within about 40 years old, occur the patient of cerebral infarction the rarest, the most common, what cerebral thrombus patient became younger becomes
Gesture is the most serious.A few days ago, reporter recognizes breathing out the medical university forth academy, because cerebral infarction connects to have in subject patient in hospital 1/3rd is
The person between twenty and fifty of about 40 years old.According to three head of the department's professor's Zhang Zhuobai introductions in the Kazakhstan forth academy of medical university nerve, nearly ten years, clinic finds
The cerebral infarction patient of the right side of fifty added two one-tenth than in the past, and the prevalence at such low age is the rarest in the past.Cause
Main cause of its morbidity is irregular, unhealthy with the diet of people and is in that stress is big, fatigue state is relevant for a long time.Doctor
Raw prompting, in daily life, it should be noted that regulation emotion, keeps appropriate motion, eats the food high containing cholesterol less, such as egg
Huang, pluck, seafood etc..--> (Heilungkiang News Network-Heilungkiang daily paper)
The sickness rate of cerebral thrombosis still has the trend of rising in recent years, also should be increasingly by the concern of people.Treat brain at present
The conventional medicine of thrombosis have low molecular dextran, nicotinic acid, papaverine, troxerutin, compound recipe pellet energy injection, ligustrazine,
Antithrombotic pill, Senc etc..Though these medicines have certain curative effect but the most of great satisfaction.
Calendula arvensis L.: for herb and the flower of the little Flos Inulae of feverfew.Summer gathers.[original shape state] annual or biennial grass
This, high 40 cm, the scattered pubescence of Herb.Stem is upright, and branch is arranged at top.Single leaf alternate;Long elliptic-lanceolate, tip is gradually
Point, edge tool rough sawn tooth, base portion wedge shape.Head inflorescence top is raw, has stalk, diameter 2 cm;Phyllary is green, linear, edge
Film quality;Edge ligulate flower, female, sulfur color, tongue piece tip 3 tooth;Central tubular flower both sexes, tip 5 splits;Holder is smooth, without torr
Sheet.Achene, back has soft thorn, and outermost columns has mouth shape directly to give birth to, and interior columns introversion is the most ring-type, without pappus.Summer at florescence.
There is cultivation in [habitat branch] flower garden, China various places more.[chemical composition] flower is containing quintessence oil, amaroid, resin, natural gum.[function cures mainly]
1. " modern Practical Chinese medicinal ": " diuresis, diaphoresis, excited, laxation, stimulates the menstrual flow.Control again perianal abscess hematochezia more than." 2. " name planted by Guangxi medicine
Record ": " blood pressure lowering." [extracts] " Chinese medicine voluminous dictionary ".
Herba thymi vulgaris: for Labiatae Thymus plant Herba thymi vulgaris Thymus serpyllum L. [T. mongolicus
Ronn.] and Herba Thymi (thymus przewalskiiNakai) T. przewalskii (Komar.) Nakai, with all herbal medicine.Summer, branch and leaf were luxuriant
Shi Caishou, pulls up Herb, cleans, cuts off root (being available for Lycopersicum esculentum), cutting, using fresh herb or dry.[nature and flavor] are pungent, tepor.[merit
Can cure mainly] expelling pathogenic wind from the body surface, promoting the circulation of QI to relieve pain, cough-relieving, blood pressure lowering.For catching a cold, cough, headache, toothache, dyspepsia, acute gastrointestinal
Inflammation, hypertension.[extracts] " whole nation Chinese herbal medicine compilation ".
Fructus Nandinae Domesticae: for the fruit of Berberidaceae plant Fructus Nandinae Domesticae Nandina domestica Thunb..Fruit is in 11~12
Month or gather February, dry.[original shape state] evergreen shrubs, high about 2m.Stem is upright, sprout yellow.Leaf alternate, the raw stem end of collection, is three
Returning winglike compound leaf, lobule keratin, ellipticity lanceolar, length 3~7cm, tip is tapering, Quan Yuan, bottle green, and often redden winter color;
Below lobule and petiole base has joint.Panicle top is raw;Tapel is taken turns more, often 3, wheel, and foreign steamer is little, inside takes turns big;Stamen 6,
Petal-shaped;Ovary is upper.Berry is spherical, cerise time ripe.Florescence 5~June, really phase 9~October.[character] fruit is spherical, directly
Footpath 7~9mm.Surface yellowish red color or reddish violet, smooth, micro-tool gloss, the most slightly concave sunken, top harbors the base for post of micro-protuberance, base
There are thin fruit stem or its mark of break in portion.Peel matter is crisp frangible, and two, seed, the most hemispherical, inner face is recessed, yellowish-brown.Sour-puckery flavor.
[chemical composition] contains isocorydine (isocorydine), protopine (protopine), 0-methyl 1-hydroxy-2-methoxy-9,10-methylenedioxyaporphine. (0-
Methyldomesticine), hydrocyanic acid etc..[nature and flavor] property is put down, sour in the mouth, sweet.[function cures mainly] astringes the lung antitussive.For chronic cough gas
Breathe heavily, pertussis.[extracts] " Chinese medicine voluminous dictionary ".
Smelly arrow dish: Capparidaceae smelly arrow dish Cleome vircosa L., with all herbal medicine.[habitat branch] Fujian, platform
Gulf, Jiangxi, Hunan, Guangdong, Guangxi, Yunnan.[nature and flavor] are bitter, pungent, temperature.Poisonous.[function cures mainly] dissipating blood stasis for subsidence of swelling, removing the necrotic tissue and promoting granulation.
[extracts] " whole nation Chinese herbal medicine compilation ".
Blatta seu periplaneta: Blattidae insecticide Australian cockroach Periplaneta australasie Fabricius or american cockroach
(big cockroach) P. americana L., is used as medicine with dry polypide.The four seasons can catch, and boiled water scalds dead, dries or dries.[nature and flavor]
Salty, cold.Slightly poisonous.[function cures mainly] dissipating blood stasis disappears knot, diuresis of detoxifying.For throat pain, tonsillitis, infantile malnutrition, liver cirrhosis
Ascites, dysuria;Snake bite and insect sting, ulcerative carbuncle toxic swelling, tinea pedis edema, asthma, stranguria with turbid discharge are controlled in external.[extracts] " whole nation medium-height grass
Medicine collects ".
Protopine (Protopine): molecular formula: C20H19NO5,Molecular weight: 353.37, CAS accession number: 130-
86-9。
19-deoxidation-15-chlorine Jia Shi cyanidin (19-Deoxy-15-Chlorojanerin): molecular formula:
C19H23ClO6Molecular weight: 382.84, CAS accession number: 62462-98-0. density: 1.336g/cm3Boiling point:
552.321 ° of C at 760 mmHg. flash-points: 287.833 ° of C.
Summary of the invention
It is an object of the invention to overcome the deficiency of background technology, it is provided that the pharmaceutical composition of a kind of effective treatment cerebral thrombosis and
Its preparation method.
The present invention adopts the following technical scheme that realization:
Composition and the weight portion of making the crude drug of the pharmaceutical composition of this treatment cerebral thrombosis be:
Calendula arvensis L. 650 750g, Herba thymi vulgaris 2450 2550g, Fructus Nandinae Domesticae 2650 2750g, smelly arrow dish 3250 3350g, roach
Dung beetle 4650 4750g, protopine 102 112g, 19-deoxidation-15-chlorine Jia Shi cyanidin 93 103g.
It is preferably used in the pharmaceutical composition for the treatment of cerebral thrombosis, is made up of the crude drug of following weight portion:
Calendula arvensis L. 700g, Herba thymi vulgaris 2500g, Fructus Nandinae Domesticae 2700g, smelly arrow dish 3300g, Blatta seu periplaneta 4700g, protopine 107g, 19-
Deoxidation-15-chlorine Jia Shi cyanidin 98g.
A kind of pharmaceutical composition treating cerebral thrombosis, it is characterised in that pharmaceutical composition can use the routine side of galenic pharmacy
Method prepares piece agent or capsule or drop pill.
A kind of pharmaceutical composition treating cerebral thrombosis, it is characterised in that pharmaceutical composition and controlling that chemical drugs or Chinese medicine form
Treat cerebral thrombosis medicine.
The preparation method of a kind of pharmaceutical composition treating cerebral thrombosis, it is characterised in that prepare as follows:
The composition of crude drug and weight portion be: Calendula arvensis L. 650 750g, Herba thymi vulgaris 2450 2550g, Fructus Nandinae Domesticae 2650
2750g, smelly arrow dish 3250 3350g, Blatta seu periplaneta 4650 4750g, protopine 102 112g, 19-deoxidation-15-chlorine Jia Shi vow
Car centautin 93 103g;
Preparation method:
(1) Calendula arvensis L., Herba thymi vulgaris, Fructus Nandinae Domesticae, smelly arrow dish, Blatta seu periplaneta, protopine, 19-deoxidation-15-chlorine are taken by crude drug proportioning
Jia Shi cyanidin, mixing, with weight percent concentration 46.5% ethanol as solvent, extract at 57 DEG C of warm macerating, extraction time is
8 times, each extraction time is 30 hours, and each solvent load is 45 times of crude drug gross weight, filters, obtains medicinal residues A and extraction
Liquid A, extracting solution A reclaim ethanol, are concentrated into relative density 1.12, filter, and medicinal liquid passes through LSA-40 macroporous adsorptive resins, first uses
Water elution, then with weight percent concentration 63% ethanol solution eluting LSA-40 macroporous adsorptive resins, collect percentage by weight dense
Spend 63% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A;
(2) take step (1) medicinal residues A, with weight percent concentration 41% ethanol as solvent, heating and refluxing extraction 11 times, carry every time
The time of taking is 1.5 hours, and each solvent load is 15 times of medicinal residues A weight, filters, obtains medicinal residues B and extracting solution B, and extracting solution B returns
Receiving ethanol, be concentrated into relative density 1.14, filter, medicinal liquid passes through DM11 macroporous adsorptive resins, first washes with water, then uses weight
Percent concentration 64% ethanol solution eluting DM11 macroporous adsorptive resins, collects weight percent concentration 64% ethanol elution,
Reclaim ethanol, concentrate drying, obtain extract B;
(3) extract A and extract B are mixed, obtain pharmaceutical composition.
The preparation method of a kind of pharmaceutical composition treating cerebral thrombosis, it is characterised in that prepare as follows:
The composition of crude drug and weight portion be: Calendula arvensis L. 700g, Herba thymi vulgaris 2500g, Fructus Nandinae Domesticae 2700g, smelly arrow dish 3300g, roach
Dung beetle 4700g, protopine 107g, 19-deoxidation-15-chlorine Jia Shi cyanidin 98g;
Preparation method:
(1) Calendula arvensis L., Herba thymi vulgaris, Fructus Nandinae Domesticae, smelly arrow dish, Blatta seu periplaneta, protopine, 19-deoxidation-15-chlorine are taken by crude drug proportioning
Jia Shi cyanidin, mixing, with weight percent concentration 46.5% ethanol as solvent, extract at 57 DEG C of warm macerating, extraction time is
8 times, each extraction time is 30 hours, and each solvent load is 45 times of crude drug gross weight, filters, obtains medicinal residues A and extraction
Liquid A, extracting solution A reclaim ethanol, are concentrated into relative density 1.12, filter, and medicinal liquid passes through LSA-40 macroporous adsorptive resins, first uses
Water elution, then with weight percent concentration 63% ethanol solution eluting LSA-40 macroporous adsorptive resins, collect percentage by weight dense
Spend 63% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A;
(2) take step (1) medicinal residues A, with weight percent concentration 41% ethanol as solvent, heating and refluxing extraction 11 times, carry every time
The time of taking is 1.5 hours, and each solvent load is 15 times of medicinal residues A weight, filters, obtains medicinal residues B and extracting solution B, and extracting solution B returns
Receiving ethanol, be concentrated into relative density 1.14, filter, medicinal liquid passes through DM11 macroporous adsorptive resins, first washes with water, then uses weight
Percent concentration 64% ethanol solution eluting DM11 macroporous adsorptive resins, collects weight percent concentration 64% ethanol elution,
Reclaim ethanol, concentrate drying, obtain extract B;
(3) extract A and extract B are mixed, obtain pharmaceutical composition.
The preparation method of a kind of pharmaceutical composition treating cerebral thrombosis, it is characterised in that pharmaceutical composition can use preparation
The conventional method learned is prepared as tablet or capsule or drop pill.
A kind of preparation method of the pharmaceutical composition treating cerebral thrombosis, it is characterised in that pharmaceutical composition and chemical drugs or in
Medicine composition treatment cerebral thrombosis medicine.
Detailed description of the invention
Embodiment 1: pharmaceutical composition for the treatment of cerebral thrombosis and preparation method thereof
The composition of crude drug and the weight portion of the pharmaceutical composition for the treatment of cerebral thrombosis be: Calendula arvensis L. 700g, Herba thymi vulgaris 2500g, sky
Zhu Zi 2700g, smelly arrow dish 3300g, Blatta seu periplaneta 4700g, protopine 107g, 19-deoxidation-15-chlorine Jia Shi cyanidin 98g;
Preparation method:
(1) Calendula arvensis L., Herba thymi vulgaris, Fructus Nandinae Domesticae, smelly arrow dish, Blatta seu periplaneta, protopine, 19-deoxidation-15-chlorine are taken by crude drug proportioning
Jia Shi cyanidin, mixing, with weight percent concentration 46.5% ethanol as solvent, extract at 57 DEG C of warm macerating, extraction time is
8 times, each extraction time is 30 hours, and each solvent load is 45 times of crude drug gross weight, filters, obtains medicinal residues A and extraction
Liquid A, extracting solution A reclaim ethanol, are concentrated into relative density 1.12, filter, and medicinal liquid passes through LSA-40 macroporous adsorptive resins, first uses
Water elution, then with weight percent concentration 63% ethanol solution eluting LSA-40 macroporous adsorptive resins, collect percentage by weight dense
Spend 63% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A;
(2) take step (1) medicinal residues A, with weight percent concentration 41% ethanol as solvent, heating and refluxing extraction 11 times, carry every time
The time of taking is 1.5 hours, and each solvent load is 15 times of medicinal residues A weight, filters, obtains medicinal residues B and extracting solution B, and extracting solution B returns
Receiving ethanol, be concentrated into relative density 1.14, filter, medicinal liquid passes through DM11 macroporous adsorptive resins, first washes with water, then uses weight
Percent concentration 64% ethanol solution eluting DM11 macroporous adsorptive resins, collects weight percent concentration 64% ethanol elution,
Reclaim ethanol, concentrate drying, obtain extract B;
(3) extract A and extract B are mixed, obtain pharmaceutical composition.
Embodiment 2: pharmaceutical composition for the treatment of cerebral thrombosis and preparation method thereof
The composition of crude drug and the weight portion of the pharmaceutical composition for the treatment of cerebral thrombosis be: Calendula arvensis L. 650g, Herba thymi vulgaris 2550g, sky
Zhu Zi 2650g, smelly arrow dish 3350g, Blatta seu periplaneta 4650g, protopine 112g, 19-deoxidation-15-chlorine Jia Shi cyanidin 93g;
Preparation method:
(1) Calendula arvensis L., Herba thymi vulgaris, Fructus Nandinae Domesticae, smelly arrow dish, Blatta seu periplaneta, protopine, 19-deoxidation-15-chlorine are taken by crude drug proportioning
Jia Shi cyanidin, mixing, with weight percent concentration 46.5% ethanol as solvent, extract at 57 DEG C of warm macerating, extraction time is
8 times, each extraction time is 30 hours, and each solvent load is 45 times of crude drug gross weight, filters, obtains medicinal residues A and extraction
Liquid A, extracting solution A reclaim ethanol, are concentrated into relative density 1.12, filter, and medicinal liquid passes through LSA-40 macroporous adsorptive resins, first uses
Water elution, then with weight percent concentration 63% ethanol solution eluting LSA-40 macroporous adsorptive resins, collect percentage by weight dense
Spend 63% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A;
(2) take step (1) medicinal residues A, with weight percent concentration 41% ethanol as solvent, heating and refluxing extraction 11 times, carry every time
The time of taking is 1.5 hours, and each solvent load is 15 times of medicinal residues A weight, filters, obtains medicinal residues B and extracting solution B, and extracting solution B returns
Receiving ethanol, be concentrated into relative density 1.14, filter, medicinal liquid passes through DM11 macroporous adsorptive resins, first washes with water, then uses weight
Percent concentration 64% ethanol solution eluting DM11 macroporous adsorptive resins, collects weight percent concentration 64% ethanol elution,
Reclaim ethanol, concentrate drying, obtain extract B;
(3) extract A and extract B are mixed, obtain pharmaceutical composition.
Embodiment 3: pharmaceutical composition for the treatment of cerebral thrombosis and preparation method thereof
The composition of crude drug and the weight portion of the pharmaceutical composition for the treatment of cerebral thrombosis be: Calendula arvensis L. 750g, Herba thymi vulgaris 2450g, sky
Zhu Zi 2750g, smelly arrow dish 3250g, Blatta seu periplaneta 4750g, protopine 102g, 19-deoxidation-15-chlorine Jia Shi cyanidin 103g;
Preparation method:
(1) Calendula arvensis L., Herba thymi vulgaris, Fructus Nandinae Domesticae, smelly arrow dish, Blatta seu periplaneta, protopine, 19-deoxidation-15-chlorine are taken by crude drug proportioning
Jia Shi cyanidin, mixing, with weight percent concentration 46.5% ethanol as solvent, extract at 57 DEG C of warm macerating, extraction time is
8 times, each extraction time is 30 hours, and each solvent load is 45 times of crude drug gross weight, filters, obtains medicinal residues A and extraction
Liquid A, extracting solution A reclaim ethanol, are concentrated into relative density 1.12, filter, and medicinal liquid passes through LSA-40 macroporous adsorptive resins, first uses
Water elution, then with weight percent concentration 63% ethanol solution eluting LSA-40 macroporous adsorptive resins, collect percentage by weight dense
Spend 63% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A;
(2) take step (1) medicinal residues A, with weight percent concentration 41% ethanol as solvent, heating and refluxing extraction 11 times, carry every time
The time of taking is 1.5 hours, and each solvent load is 15 times of medicinal residues A weight, filters, obtains medicinal residues B and extracting solution B, and extracting solution B returns
Receiving ethanol, be concentrated into relative density 1.14, filter, medicinal liquid passes through DM11 macroporous adsorptive resins, first washes with water, then uses weight
Percent concentration 64% ethanol solution eluting DM11 macroporous adsorptive resins, collects weight percent concentration 64% ethanol elution,
Reclaim ethanol, concentrate drying, obtain extract B;
(3) extract A and extract B are mixed, obtain pharmaceutical composition.
Embodiment 4: the preparation of tablet
Example 1 pharmaceutical composition 300g, adds starch 110g, mixing, pelletizes, be dried, add microcrystalline Cellulose 35g, stearic
Acid magnesium 3g, mixing, it is pressed into 1000, obtains medicinal composition tablets.
Embodiment 5: the preparation of capsule
Example 2 pharmaceutical composition 302g, adds starch 90g, mixing, pelletizes, be dried, granulate, add appropriate magnesium stearate,
Mixing, obtains medicament composition capsule by encapsulated 1000.
Embodiment 6: the preparation of drop pill
Weigh polyethylene glycol 6000 193g water-bath (80 DEG C) heating and boil molten, add embodiment 3 pharmaceutical composition 14g, fully stir
Mixing uniformly, with liquid paraffin as coolant, put in glass tubing (4*80cm), chilling temperature is 5 DEG C, and drip internal-and external diameter is 7.0/
2.0 (mm/mm), drip is 2.5cm away from liquid level, drips fast with 50 every point as optimum condition, blots the cold of drop pill surface with cotton
Solidifying agent, obtains medicament composition dropping pills.
Embodiment 7: the pharmaceutical composition for the treatment of cerebral thrombosis
The composition of crude drug and the weight portion of the pharmaceutical composition for the treatment of cerebral thrombosis be:
Fructus Nandinae Domesticae 3050g, Blatta seu periplaneta 4550g, protopine 82g, 19-deoxidation-15-chlorine Jia Shi cyanidin 65g.
Embodiment 8: the pharmaceutical composition for the treatment of cerebral thrombosis
The composition of crude drug and the weight portion of the pharmaceutical composition for the treatment of cerebral thrombosis be:
Fructus Nandinae Domesticae 3000g, Blatta seu periplaneta 4600g, protopine 72g, 19-deoxidation-15-chlorine Jia Shi cyanidin 75g.
Embodiment 9: the pharmaceutical composition for the treatment of cerebral thrombosis
The composition of crude drug and the weight portion of the pharmaceutical composition for the treatment of cerebral thrombosis be:
Fructus Nandinae Domesticae 3100g, Blatta seu periplaneta 4500g, protopine 92g, 19-deoxidation-15-chlorine Jia Shi cyanidin 55g.
Experimental example 1: the experimental study for the treatment of cerebral thrombosis
1 data and method
1.1 physical data
Cerebral thrombus patient 100 example choosing Shandong Qilu Hospital's treatment of in November, 2013~in November, 2014 is right as research
As, all inform selected patient and obtain agreement.It is divided at random observation group and each 50 examples of matched group, man 26 in matched group
Example, female 24 example, age 41~73 years old, the mean age is (55.5 ± 6.8) year, complication with diabetes l0 example, complicated hypertension 35 example,
Merge coronary heart disease 5 example;Male 25 examples in observation group, female 25 example, age 40~73 years old, the mean age be (56.3 ± 7.6) year, close
And diabetes l0 example, complicated hypertension 36 example, merge coronary heart disease 4 example.All patients all meet diagnostic criteria and sweep through brain CT
Retouch and make a definite diagnosis, get rid of serious hepatic and kidney function obstacle person.Two groups of aspect comparing difference not statistically significants such as patient age, sex (
0.05), there is comparability.
1 .2 Therapeutic Method
1.2 .1 matched groups use the treatment of low molecular dextran, SHENMAI ZHUSHEYE, citicoline.250~500m low molecule
The admixing medical solutions of dextran glucose injection, 0.5g citicoline and 250m L 5% glucose injection, 40mL joins
Wheat injection and the admixing medical solutions of 250mL 5% glucose injection, intravenous drip, 1 time/d.Glucose is noted by diabetics
Penetrate liquid and replace to normal saline.Oral 50mg enteric coated aspirin sheet, 100mgVitE, 1 time/d, be used in conjunction 3 months.Give simultaneously
The symptomatic treatments such as fall intracranial pressure, blood sugar lowering, blood pressure lowering.
1.2.2 observation group
On the basis of the western medical treatment of matched group, add this pharmaceutical composition (embodiment 1 pharmaceutical composition lot number 20121229)
Treatment, three times a day, each 1.5g, carry out efficacy determination after being used in conjunction March.
1.3 evaluation index
(1) " apoplexy patient neurological deficits score standard " with reference to nineteen ninety-five whole nation cerebrovascular academic conference revision is carried out
Scoring, the slip of two groups of scorings after comparison therapy.Cure: scoring reduces more than 76%, and life is taken care of oneself completely, Return to work hilllock
Position;Effective: scoring reduces 50%~75%, and part life can be taken care of oneself, and can be engaged in simple activities;Effective: scoring subtract 11%~
50%, can live under helping, it is impossible to be engaged in activity;Invalid: scoring reduces less than 10% or increased, and living condition is without changing
Kind, the state of an illness even deteriorates or dead without taking a turn for the better.Total effective rate=(cure+effective+effectively)/total number of cases.(2) two groups of treatments are compared
The change of infarction side cerebral blood flow, flow velocity front and back.
1.4 statistical method
Using SPSSl1.0 statistical software to carry out statistical procedures the data obtained, data are with X ± S) represent, wherein measure
Data uses t inspection, and enumeration data uses X2Inspection, P < 0.05 is statistically significant.
2 results
2.1 liang of group patient clinical therapeutic effect compare
Observation group's total effective rate 94.0%, matched group is 72.0%, and two groups are compared, and has significant difference (P < 0.05), sees
Examine group clinical efficacy apparently higher than matched group.It is shown in Table 1.
1 liang of table group patient clinical therapeutic effect comparative example
Group | Number of cases | Cure | Effective | Effectively | Invalid | Total effective rate (%) |
Matched group | 50 | 10 | 13 | 13 | 14 | 72.0 |
Observation group | 50 | 22 | 17 | 8 | 3 | 94.0 |
Before and after 2.2 liang of group treatments, relatively two groups treatment Cerebral Blood Flow Followings of cerebral blood flow, velocity ratio and cerebral blood flow speed all have increase, see
Examine group treatment after with treatment before compared with, all there were significant differences for cerebral blood flow and cerebral blood flow speed (P < 0.05), after treatment of control group with
Comparing before treatment, cerebral blood flow and cerebral blood flow speed are without significant difference (P > 0.05), the cerebral blood flow after observation group's treatment and brain blood
Flow velocity compared with matched group, difference statistically significant (P < 0.05).It is shown in Table 2.
Before and after the group treatment of 2 liang of table, infarction side cerebral blood flow, velocity ratio are relatively
Result observation group total effective rate is 94.0%, matched group be 72.0%, simultaneously observation group's cerebral blood flow and cerebral blood flow speed also
Apparently higher than matched group.In sum, this pharmaceutical composition (embodiment 1 pharmaceutical composition lot number 20121229) treatment clinic is treated
Effect is notable, is worthy to be popularized.
Experimental example 2, model case
Xiao XX, man, 52 years old, suffer from hypertension for many years, but the most not asymptomatic.He is the people that a self-disciplining is very poor, takes out at ordinary times
Cigarette is severe.Feel to have the pins and needles during in December, 2014, go hospital diagnosis to say slight thrombosis, all right after two weeks the most in hospital
?.Somatosensory is the most fine later.Feeling like jelly until feeling that trick is unable on February 19th, 2015, going to hospital to see is thrombosis shape again
Cheng Liao, had beaten drop at that time, but when late home is lived, and second day as a result morning fell down when going to toilet suddenly, and the state of an illness increases the weight of suddenly.
Left side trick is the most active, the thinking also ratio compared with normal but he speaks, it is impossible to oneself stands up.Start this medicine oral on February 20th, 2015
Compositions (embodiment 1 pharmaceutical composition lot number 20121229) is treated, three times a day, each 1.5g, permissible after serveing on 4 months
Go to ground activity, communication that can be more visible with people, the check of 5 Ge Yuehou hospitals, blood pressure is normal, lives normal, continues clothes afterwards
Thoroughly cured with 2 months.
Thunder XX, man, 54 years old, in evening on October 15th, 2014, unexpected cerebral thrombosis showed effect, unconscious, is sent in a hurry hospital of city,
Rescuing, on inspection, bilateral cerebral blocks, and doctor requires hospitalization at once, but, one is admitted to hospital must hand over 2000 yuan
The cash pledge of money, owing to being poorly off, cannot take out the most money, so, beat transfusion bottle and just gone home.The when of 7th day, always
Other just falls ill on a heatable brick bed, it is impossible to move, and left hand and some consciousness of arms and legs do not have yet, and speak not clear, and then 2015
Start oral this pharmaceutical composition (embodiment 1 pharmaceutical composition lot number 20121229) treatment on February 28, in, three times a day, every time
1.5g, can be with Go to ground activity after serveing on 2 months, communication that can be more visible with people, and the check of 4 Ge Yuehou hospitals, blood pressure is normal, raw
Live normal, after continue to take and thoroughly cure for 2 months.
Claims (8)
1. the pharmaceutical composition treating cerebral thrombosis, it is characterised in that make composition and the weight of the crude drug of this pharmaceutical composition
Amount part is:
Calendula arvensis L. 650-750g, Herba thymi vulgaris 2450-2550g, Fructus Nandinae Domesticae 2650-2750g, smelly arrow dish 3250-3350g, Blatta seu periplaneta
4650-4750g, protopine 102-112g, 19-deoxidation-15-chlorine Jia Shi cyanidin 93-103g.
A kind of pharmaceutical composition treating cerebral thrombosis, it is characterised in that make this pharmaceutical composition
The composition of crude drug and weight portion be:
Calendula arvensis L. 700g, Herba thymi vulgaris 2500g, Fructus Nandinae Domesticae 2700g, smelly arrow dish 3300g, Blatta seu periplaneta 4700g, protopine 107g, 19-
Deoxidation-15-chlorine Jia Shi cyanidin 98g.
A kind of pharmaceutical composition treating cerebral thrombosis, it is characterised in that pharmaceutical composition can be adopted
It is prepared as tablet or capsule or drop pill by the conventional method of galenic pharmacy.
A kind of pharmaceutical composition treating cerebral thrombosis, it is characterised in that pharmaceutical composition and chemistry
Medicine or the treatment cerebral thrombosis medicine of Chinese medicine composition.
5. the preparation method of the pharmaceutical composition treating cerebral thrombosis, it is characterised in that prepare as follows:
The composition of crude drug and weight portion be: Calendula arvensis L. 650-750g, Herba thymi vulgaris 2450-2550g, Fructus Nandinae Domesticae 2650-2750g,
Smelly arrow dish 3250-3350g, Blatta seu periplaneta 4650-4750g, protopine 102-112g, 19-deoxidation-15-chlorine Jia Shi cyanidin 93-
103g;
Preparation method:
(1) Calendula arvensis L., Herba thymi vulgaris, Fructus Nandinae Domesticae, smelly arrow dish, Blatta seu periplaneta, protopine, 19-deoxidation-15-chlorine are taken by crude drug proportioning
Jia Shi cyanidin, mixing, with weight percent concentration 46.5% ethanol as solvent, extract at 57 DEG C of warm macerating, extraction time is
8 times, each extraction time is 30 hours, and each solvent load is 45 times of crude drug gross weight, filters, obtains medicinal residues A and extraction
Liquid A, extracting solution A reclaim ethanol, are concentrated into relative density 1.12, filter, and medicinal liquid passes through LSA-40 macroporous adsorptive resins, first uses
Water elution, then with weight percent concentration 63% ethanol solution eluting LSA-40 macroporous adsorptive resins, collect percentage by weight dense
Spend 63% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A;
(2) take step (1) medicinal residues A, with weight percent concentration 41% ethanol as solvent, heating and refluxing extraction 11 times, carry every time
The time of taking is 1.5 hours, and each solvent load is 15 times of medicinal residues A weight, filters, obtains medicinal residues B and extracting solution B, and extracting solution B returns
Receiving ethanol, be concentrated into relative density 1.14, filter, medicinal liquid passes through DM11 macroporous adsorptive resins, first washes with water, then uses weight
Percent concentration 64% ethanol solution eluting DM11 macroporous adsorptive resins, collects weight percent concentration 64% ethanol elution,
Reclaim ethanol, concentrate drying, obtain extract B;
(3) extract A and extract B are mixed, obtain pharmaceutical composition.
The preparation method of a kind of pharmaceutical composition treating cerebral thrombosis, it is characterised in that by as follows
Prepared by step:
The composition of crude drug and weight portion be: Calendula arvensis L. 700g, Herba thymi vulgaris 2500g, Fructus Nandinae Domesticae 2700g, smelly arrow dish 3300g, roach
Dung beetle 4700g, protopine 107g, 19-deoxidation-15-chlorine Jia Shi cyanidin 98g;
Preparation method:
(1) Calendula arvensis L., Herba thymi vulgaris, Fructus Nandinae Domesticae, smelly arrow dish, Blatta seu periplaneta, protopine, 19-deoxidation-15-chlorine are taken by crude drug proportioning
Jia Shi cyanidin, mixing, with weight percent concentration 46.5% ethanol as solvent, extract at 57 DEG C of warm macerating, extraction time is
8 times, each extraction time is 30 hours, and each solvent load is 45 times of crude drug gross weight, filters, obtains medicinal residues A and extraction
Liquid A, extracting solution A reclaim ethanol, are concentrated into relative density 1.12, filter, and medicinal liquid passes through LSA-40 macroporous adsorptive resins, first uses
Water elution, then with weight percent concentration 63% ethanol solution eluting LSA-40 macroporous adsorptive resins, collect percentage by weight dense
Spend 63% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A;
(2) take step (1) medicinal residues A, with weight percent concentration 41% ethanol as solvent, heating and refluxing extraction 11 times, carry every time
The time of taking is 1.5 hours, and each solvent load is 15 times of medicinal residues A weight, filters, obtains medicinal residues B and extracting solution B, and extracting solution B returns
Receiving ethanol, be concentrated into relative density 1.14, filter, medicinal liquid passes through DM11 macroporous adsorptive resins, first washes with water, then uses weight
Percent concentration 64% ethanol solution eluting DM11 macroporous adsorptive resins, collects weight percent concentration 64% ethanol elution,
Reclaim ethanol, concentrate drying, obtain extract B;
(3) extract A and extract B are mixed, obtain pharmaceutical composition.
The preparation method of a kind of pharmaceutical composition treating cerebral thrombosis, it is characterised in that medicine group
Compound can use the conventional method of galenic pharmacy to be prepared as tablet or capsule or drop pill.
The preparation method of a kind of pharmaceutical composition treating cerebral thrombosis, it is characterised in that medicine group
Compound and chemical drugs or Chinese medicine composition treatment cerebral thrombosis medicine.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106581482A (en) * | 2016-12-10 | 2017-04-26 | 济南昊雨青田医药技术有限公司 | Medicinal composition for treating pyelonephritis, and preparation method thereof |
CN106727878A (en) * | 2016-12-10 | 2017-05-31 | 济南昊雨青田医药技术有限公司 | It is a kind of to treat pharmaceutical composition of cerebral thrombus and preparation method thereof |
CN109125355A (en) * | 2018-08-03 | 2019-01-04 | 昆明医科大学第附属医院 | The grand antiplatelet of heart arteries and veins and antithrombotic pharmacology action |
-
2016
- 2016-07-04 CN CN201610515685.2A patent/CN106109564A/en not_active Withdrawn
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106581482A (en) * | 2016-12-10 | 2017-04-26 | 济南昊雨青田医药技术有限公司 | Medicinal composition for treating pyelonephritis, and preparation method thereof |
CN106727878A (en) * | 2016-12-10 | 2017-05-31 | 济南昊雨青田医药技术有限公司 | It is a kind of to treat pharmaceutical composition of cerebral thrombus and preparation method thereof |
CN109125355A (en) * | 2018-08-03 | 2019-01-04 | 昆明医科大学第附属医院 | The grand antiplatelet of heart arteries and veins and antithrombotic pharmacology action |
CN109125355B (en) * | 2018-08-03 | 2022-07-08 | 昆明医科大学第一附属医院 | Psychopharmacology application of Xinmailong for anti-platelet and anti-thrombus |
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