CN106729025A - Prevent and treat pharmaceutical composition of cold in children and preparation method thereof - Google Patents
Prevent and treat pharmaceutical composition of cold in children and preparation method thereof Download PDFInfo
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 54
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 239000003814 drug Substances 0.000 claims abstract description 49
- 229940079593 drug Drugs 0.000 claims abstract description 33
- 241001517312 Calanthe Species 0.000 claims abstract description 24
- 241001164374 Calyx Species 0.000 claims abstract description 21
- 239000000203 mixture Substances 0.000 claims abstract description 21
- 241001571354 Dichrocephala Species 0.000 claims abstract description 20
- 241000427250 Moehringia Species 0.000 claims abstract 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 126
- 239000000284 extract Substances 0.000 claims description 56
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- 238000000605 extraction Methods 0.000 claims description 28
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- 239000012467 final product Substances 0.000 claims description 24
- 239000007788 liquid Substances 0.000 claims description 22
- 238000001914 filtration Methods 0.000 claims description 14
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- 238000007796 conventional method Methods 0.000 claims description 3
- 238000009472 formulation Methods 0.000 abstract 1
- 241000947848 Arenaria ciliata Species 0.000 description 16
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- DKXULEFCEORBJK-UHFFFAOYSA-N magnesium;octadecanoic acid Chemical compound [Mg].CCCCCCCCCCCCCCCCCC(O)=O DKXULEFCEORBJK-UHFFFAOYSA-N 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
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- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
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- 102000002322 Egg Proteins Human genes 0.000 description 1
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- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/10—Bryophyta (mosses)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/50—Methods involving additional extraction steps
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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Abstract
Pharmaceutical composition of cold in children and preparation method thereof is prevented and treated the invention discloses a kind of, pharmaceutical composition of the present invention is with auriculate dichrocephala herb or leaf, sickle calyx calanthe, small pigeon-wheat, plateau sandwort, lady's-grass as bulk drug, proportioning is formed, routinely various formulations can be made by preparation process, prevent and treat cold in children evident in efficacy.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of pharmaceutical composition for preventing and treating cold in children and its preparation side
Method.
Background technology
Flu is commonly called as " cold ", is the most common exogenous diseases of children.Mainly due to caused by experiencing ailment said due to cold or exposure.It is clinical sending out
Heat, aversion to cold, headache, nasal obstruction runny nose, cough are cardinal symptom.There are a generation in the four seasons, weather cataclysm and the winter and spring incidence of disease compared with
It is high.Children's internal organs are tender and lovely, and skin dredges thin, weakened defensive QI, and trembling with fear to warm up in addition is unable to self-regulated, it is easy to being invaded by exogenous pathogen,invasion of exogenous pathogen.Weather during Chang Yinsi
Cataclysm, cold and hot not normal, exopathogen is taken advantage of a weak point in opponent's defence invasion and attack, leads to flu.So because of children " internal organs are weak, easily empty easily real, easily cold easily heat ", if
Treat not in time or control by mistake, pneumonia, viral encephalitis, vital myocarditis etc. can be developed into.Cold in children heat is dialectical more than cold
When to pharyngitis person, even if thin white fur of tongue and moisten, to be also thought of as wind-heat syndrome, it is vertical to have cold as also strongly fragrant in the majority with cold bag heat.It is many
Have accumulation of heat in category, catch cold, should not only solve exterior cold during treatment again clearly in it is hot.Exopathogen invasion must give outlet, and ten thousand can not close door by bandit.
Its outlet has three, be sweat and two just.Children are the body of " immature yin and yang ".Due to " undeveloped infantile YIN ", easily into impairment of yin sun is high thus performance
It is the syndrome of heat.Children's warm disease is relatively grown up common, and temperature is much more evil from cremate, therefore easily " heat ".Due to children " unfilled infantile YANG ", a lot
Chinese medicine is generally the product of bitter cold, and bitter cold can cut the gas for cutting down hair tonic, therefore necessary middle disease is stopped during application.
Plateau sandwort：This product is pinkwort plateau sandwort Arenaria przewalskii Maxim. and its belongs to together
Various plants dry herb.7~August gathers herb, cleans soil, dries.【Nature and flavor】Sweet, bitter, cold.【Function with cure mainly】Clearly
Hot profit lung.For pneumonia, pulmonary tuberculosis, the disease such as lung heat cough and asthma.【Proterties】This product is often crimped to bulk.Root dark brown, yellowish-brown is main
Root woody part white.Stem foot harbors the withered leaf sheath of threadiness, and close by filbert glandular hairs.Blade is linear to lanceolar, and base portion is wider,
Joint is into sheath, and middle rib is obvious.Flower basidixed, crushes more, launches visible bract green, ovate-elliptic, by glandular hairs；Sepal is pale purple
Color；Petal is fallow (being white when fresh).Gas is micro-, taste micro-sweet, hardship.Record and issue Tibetan medicine standard in the Ministry of Public Health（First）, mark
Quasi- numbering：WS3-BC-0084-95.
Auriculate dichrocephala herb or leaf：This product is composite family Dichrocephala plant dichrocephala Dichrocephala auriculata (Thunb.)
The herb of Druce [Ethulia auriculata Thunb.].Summer, autumn harvesting, dry.【Nature and flavor】Bitter；It is pungent；It is mild-natured.
【Indication】Promoting blood circulation for regulating menstruation；Removing toxicity for detumescence.Main irregular menstruation；Sprain and swell and ache；Serious case of furuncle；Venomous snake bite.【Former phytomorph】Fish
The careless annual herb of eye, 15-50cm high.Stem is upright or paving dissipates, without hair or by pubescence.Blade is avette, oval or drapes over one's shoulders pin
Shape, 3-10cm long, major part plumage split, Capping piece is roomy, wide up to 4cm, normal 1 pair of side sliver, and dilute 2 pairs, two sides is without hair or by sparse short
Pubescence.Capitulum is minimum, spherical, diameter about 5mm, is born in dichotomy top, and most capitulums are on stem top or branch top
Line up loose umbrella room shape in end；Stalk is up to 3cm；Phyllary 1-2 layers；Holder semicircle spherical protuberances, above hold level with both hands；Disc floret both sexes；Energy
Educate；Corolla tip has 4-5 teeth.Achene is flat, the edge for having thickening；Without pappus.At the beginning of late summer at florescence to the winter.Record in the big diction of Chinese medicine
Allusion quotation.
Sickle calyx calanthe：It is orchid family Calanthe plant pubescence calanthe Chlanthe puberula Lindl.ex
Wall.[C.amoena W.W.Smith；C.lepida W.W.Smith] pseudobulb and herb.Summer, autumn harvesting, clean,
Dry.【Nature and flavor】Taste is pungent；It is sweet；It is mild-natured.【Indication】Moisten the lung and relieve the cough；Blood circulation promoting and dispersing pathogen accumulation；Subdhing swelling and detoxicating.Main acute bronchus
It is scorching；Chronic bronchitis；Pulmonary tuberculosis cough；Scrofula；Traumatic injury；Hemorrhoid；Venomous snake bite.【Former phytomorph】Pubescence calanthe,
Terrestrial plant.Stem is short.Ye Jinji gives birth to, 4-5 pieces；Blade is oval, is about 20cm, 4-7cm wide, the sharp point of tip, base portion tool short handle.
Scape grows from leafage, outside hypsophyll；Raceme 8-15cm long, the most flowers of sparsely grow；Petal piece narrow lanceolar, about etc. is longer than
Bennet（Connect ovary）, tip is long tapering；Sepal and petal reflexed backward, are about 1.4cm；The oblique ovum shape lanceolar of sepal, it is wide about
6mm, tip is tapering in awns；Petal lavender, narrow lanceolar, about 1mm wide, tip is tapering；Lip is open and flat, than petal and sepal
Greatly, 3 are split, and middle sliver is oval, narrower than side sliver, and tip is tapering or sharp point, and shape is eroded at edge, and side sliver sickle shaped is interior curved, tightly
Sliver in patch, tip is blunt；Without away from.Record in dictionary of medicinal plant.
Lady's-grass：It is grass family knotgrass plant Digitaria sanguinalis Digitaria sanguinalis (L.) Scop. [Panicum
Sangui-nale L.] herb.Summer, autumn tap herb, dry.【Nature and flavor】It is sweet；It is cold.【Indication】Improving eyesight moistening lung.It is main
Mesh is secretly failed to understand；Cough with lung heat.【Proterties】Dry herb 40-100cm long.Stalk branch, takes root on the section of bottom.Intact leaf strip is draped over one's shoulders
Aciculiform, 8-17cm long, 5-15mm wide, tip is tapering or short point.Base portion blunt circle, two sides is without hair or sparsely grow pubescence, loose armful of leaf sheath
Stem, without hair or sparsely grow pubescence.【Former phytomorph】Lady's-grass, annual herb, culm base is often inclined, and is easily taken root after soil, high
40-100cm.Footpath 2-3mm.Leaf sheath Chang Shusheng has the fur of wart base, dilute without hair；Tip of a leaf 1-3mm long；Blade wire lanceolar is long
8-17cm, 5-15mm wide, two sides are dredged by fur or without hair, and edge is thickening and coarse.Raceme is thin and delicate, 3-10 pieces, 5- long
15cm, is generally arranged in stalk top into finger-like, and cob about 1mm wide, middle rib white accounts for the 1/3 of width；Small spike length 3-3.5mm, drapes over one's shoulders
Aciculiform, twin cob is respectively saved, and one has long handle, and one has extremely short handle or a few stockless；1st clever obtuse triangle, is about 0.2mm, acrotism,
The 1/2-3/4 of the 2nd clever a length of small ear, it is narrow, have between very unconspicuous 3 arteries and veins, arteries and veins and edge has short cilium mostly；1st lemma with
Small ear is isometric, there is a 5-7 arteries and veins, and central 3 veinclearing shows, between arteries and veins distance it is wider and without hair, side form is very approached, sometimes not substantially, without hair or
The adhesion pubescence between arteries and veins, the 2nd lemma nearly keratin, celadon is waited and is longer than the 1st lemma；Flower pesticide is about 1mm.Flower, the fruiting period 6-9 months.Receive
It is loaded in dictionary of medicinal plant.
Small pigeon-wheat：It is pigeon-wheat section Pogonatum plant Pogonatum inflexum (Lindb.) Lac Pogonatum inflexum
（Lindb.) the herb of Lac. ［ Polytricum inflexum Lindb. ］.The 5-7 months harvest, and clean, and dry.【Nature and flavor】It is pungent；
Temperature.【Indication】Tranquilizing and allaying excitement；Dissipate the stasis of blood；Hemostasis.Main palpitation and severe palpitation；Insomnia and dreamful sleep；Traumatic injury；Spit blood.【Chemical analysis】
Containing taurine.【Proterties】This product is the several plants of agglomerates gathered together together, stem length 2-8cm, dirty-green or yellowish-brown.Moistening is separated
Afterwards, every plant of stem is single, the thin rhizoid of the close life of base portion.The wealthy lanceolar of leaf, tapering, base portion avette, the indent of circle, demisheath shape, edge has slightly
Sawtooth；Middle rib is thick, and up to blade tip, the outside of belly is covered with comb piece.Some visible elongate setas, it is orange-yellow.Sporangium cylinder, opercule has length
Beak, yellow of capsule cap gathering becomes mildewed.Gas is micro-, lightly seasoned.Record in dictionary of medicinal plant.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of pharmaceutical composition for effectively preventing and treating cold in children
And preparation method thereof.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for being made the bulk drug of the pharmaceutical composition for preventing and treating cold in children be：
The auriculate dichrocephala herb or leaf 220-226 weight portion sickle calyx small pigeon-wheat 210-214 weight portions plateau fleas of calanthe 230-238 weight portions
Sew 130-134 weight portion lady's-grass 110-112 weight portions.
The pharmaceutical composition for preventing and treating cold in children is preferably used in, is made up of the bulk drug of following weight portion：
The small weight portion of 212 weight portion plateau sandwort of pigeon-wheat 132 of the weight portion of 223 weight portion sickle calyx calanthe of auriculate dichrocephala herb or leaf 234
The weight portion of lady's-grass 111.
A kind of pharmaceutical composition for preventing and treating cold in children, it is characterised in that pharmaceutical composition can be using the routine of galenic pharmacy
Method prepares piece agent or capsule or dripping pill.
A kind of pharmaceutical composition for preventing and treating cold in children, it is characterised in that pharmaceutical composition is constituted with chemical drugs or Chinese medicine
Prevent and treat cold in children medicine.
A kind of preparation method of the pharmaceutical composition for preventing and treating cold in children, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：The auriculate dichrocephala herb or leaf 220-226 weight portion sickle calyx calanthe small golden hairs of 230-238 weight portions
Moss 210-214 weight portions plateau sandwort 130-134 weight portion lady's-grass 110-112 weight portions；
Preparation method：
（1）Auriculate dichrocephala herb or leaf, sickle calyx calanthe, small pigeon-wheat, plateau sandwort, lady's-grass are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 32% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 26 times, and each extraction time is 54 hours, every time
Solvent load is 18 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative
Density 1.06, filtration, liquid is first washed with water by NKA-9 large pore resin absorption columns, then with the second of weight percent concentration 14%
Alcoholic solution elutes NKA-9 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 14%, reclaims ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 43% as solvent, heating and refluxing extraction 17 times is carried every time
The time is taken for 0.3 hour, each solvent load is 22 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.13 is concentrated into, filtered, liquid is first washed with water by SP825 large pore resin absorption columns, then with again
Amount percent concentration 67% ethanol solution wash-out SP825 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 67%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition for preventing and treating cold in children, it is characterised in that make as follows
It is standby：
The composition and weight portion of bulk drug be：The small weight of pigeon-wheat 212 of weight portion of 223 weight portion sickle calyx calanthe of auriculate dichrocephala herb or leaf 234
The weight portion of 132 weight portion lady's-grass of amount part plateau sandwort 111；
Preparation method：
（1）Auriculate dichrocephala herb or leaf, sickle calyx calanthe, small pigeon-wheat, plateau sandwort, lady's-grass are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 32% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 26 times, and each extraction time is 54 hours, every time
Solvent load is 18 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative
Density 1.06, filtration, liquid is first washed with water by NKA-9 large pore resin absorption columns, then with the second of weight percent concentration 14%
Alcoholic solution elutes NKA-9 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 14%, reclaims ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 43% as solvent, heating and refluxing extraction 17 times is carried every time
The time is taken for 0.3 hour, each solvent load is 22 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.13 is concentrated into, filtered, liquid is first washed with water by SP825 large pore resin absorption columns, then with again
Amount percent concentration 67% ethanol solution wash-out SP825 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 67%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for preventing and treating cold in children, it is characterised in that pharmaceutical composition can be using system
The conventional method of agent prepares piece agent or capsule or dripping pill.
A kind of preparation method of the pharmaceutical composition for preventing and treating cold in children, it is characterised in that pharmaceutical composition and chemical drugs or
Chinese medicine composition prevents and treats cold in children medicine.
It is evident in efficacy that pharmaceutical composition prevents and treats cold in children.
Specific embodiment
Embodiment 1：Prevent and treat pharmaceutical composition of cold in children and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of cold in children be：Auriculate dichrocephala herb or leaf 223g sickle calyx calanthes
The small pigeon-wheat 212g plateaus sandwort 132g lady's-grass 111g of 234g；
Preparation method：
（1）Auriculate dichrocephala herb or leaf, sickle calyx calanthe, small pigeon-wheat, plateau sandwort, lady's-grass are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 32% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 26 times, and each extraction time is 54 hours, every time
Solvent load is 18 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative
Density 1.06, filtration, liquid is first washed with water by NKA-9 large pore resin absorption columns, then with the second of weight percent concentration 14%
Alcoholic solution elutes NKA-9 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 14%, reclaims ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 43% as solvent, heating and refluxing extraction 17 times is carried every time
The time is taken for 0.3 hour, each solvent load is 22 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.13 is concentrated into, filtered, liquid is first washed with water by SP825 large pore resin absorption columns, then with again
Amount percent concentration 67% ethanol solution wash-out SP825 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 67%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Prevent and treat pharmaceutical composition of cold in children and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of cold in children be：Auriculate dichrocephala herb or leaf 220g sickle calyx calanthes
The small pigeon-wheat 210g plateaus sandwort 134g lady's-grass 110g of 238g；
Preparation method：
（1）Auriculate dichrocephala herb or leaf, sickle calyx calanthe, small pigeon-wheat, plateau sandwort, lady's-grass are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 32% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 26 times, and each extraction time is 54 hours, every time
Solvent load is 18 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative
Density 1.06, filtration, liquid is first washed with water by NKA-9 large pore resin absorption columns, then with the second of weight percent concentration 14%
Alcoholic solution elutes NKA-9 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 14%, reclaims ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 43% as solvent, heating and refluxing extraction 17 times is carried every time
The time is taken for 0.3 hour, each solvent load is 22 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.13 is concentrated into, filtered, liquid is first washed with water by SP825 large pore resin absorption columns, then with again
Amount percent concentration 67% ethanol solution wash-out SP825 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 67%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Prevent and treat pharmaceutical composition of cold in children and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of cold in children be：Auriculate dichrocephala herb or leaf 226g sickle calyx calanthes
The small pigeon-wheat 214g plateaus sandwort 130g lady's-grass 112g of 230g；
Preparation method：
（1）Auriculate dichrocephala herb or leaf, sickle calyx calanthe, small pigeon-wheat, plateau sandwort, lady's-grass are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 32% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 26 times, and each extraction time is 54 hours, every time
Solvent load is 18 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative
Density 1.06, filtration, liquid is first washed with water by NKA-9 large pore resin absorption columns, then with the second of weight percent concentration 14%
Alcoholic solution elutes NKA-9 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 14%, reclaims ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 43% as solvent, heating and refluxing extraction 17 times is carried every time
The time is taken for 0.3 hour, each solvent load is 22 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.13 is concentrated into, filtered, liquid is first washed with water by SP825 large pore resin absorption columns, then with again
Amount percent concentration 67% ethanol solution wash-out SP825 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 67%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
The pharmaceutical composition 51g of Example 1, adds starch 67g, mixes, and granulation is dried, plus microcrystalline cellulose 40g, stearic acid
Magnesium 3g, mixes, and is pressed into 400, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
The pharmaceutical composition 220g of Example 2, adds starch 306g, mixes, and granulation is dried, whole grain, adds appropriate stearic acid
Magnesium, mixes, and encapsulated 1800, obtains final product medicament composition capsule.
Embodiment 6：The preparation of dripping pill
Weigh (80 DEG C) heating of Macrogol 6000 183g water-baths and boil molten, add the pharmaceutical composition 10.3g of embodiment 3, fully
Stir, with atoleine as cooling agent, put glass tube（4*80cm）In, chilling temperature is 5 DEG C, and drip internal-and external diameter is 7.0/
2.0 (mm/mm), drip is 2.4cm away from liquid level, and drop speed is optimum condition with every point 54 drop, and the cold of dripping pill surface is blotted with cotton
Solidifying agent, obtains final product medicament composition dropping pills.
Embodiment 7：Prevent and treat the pharmaceutical composition of cold in children
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of cold in children be：
The weight portion of 100 weight portion plateau sandwort of small pigeon-wheat, 280 weight portion sickle calyx calanthe 190.
Embodiment 8：Prevent and treat the pharmaceutical composition of cold in children
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of cold in children be：
The weight portion of 120 250 weight portion lady's-grass of weight portion plateau sandwort of small pigeon-wheat 160.
Embodiment 9：Prevent and treat the pharmaceutical composition of cold in children
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of cold in children be：
The weight portion of 150 240 weight portion lady's-grass of weight portion plateau sandwort of small pigeon-wheat 170.
Experimental example 1：Prevent and treat the experimental study of cold in children
1 clinical data
45 patients are all my section out-patient, man 23, female 22,3 months to 1 years old infant 12,1-5 Sui infant
18,5-2 years old infant 15.Course of disease 1-4d.All cases meet《TCM Pediatrics disease Standardization of diagnosis and curative effect》In sense
Diagnostic criteria is emitted, the diseases such as measles, scarlet fever, meningococal meningitis, polio are excluded.Above-mentioned case is pressed into outpatient service
Medical order is randomly divided into observation group and control group, wherein observation group 23 and control group 22.Two groups the age, sex and
The aspects such as the course of disease have comparativity（P>0.05）.
2 methods
2.1 treatment methods
Observation group's pharmaceutical composition（The pharmaceutical composition of embodiment 1）Treatment, orally, each 0.3g, 3 times a day.Control group is adopted
Potassium piece, Ribavirin, swap buffers or the anti-electuary of chaste tree are tieed up with penicillin orally, dosage is depending on child physical endowment amount.Two groups of trouble
Youngster's body temperature gives antipyretic application when being higher than 38.5 DEG C.
2. 2 statistical method
Total effective rate compares between two groups, using Chi-square Test.
3 observation of curative effect
3. 1 criterion of therapeutical effect
Reference《TCM Pediatrics disease Standardization of diagnosis and curative effect》.Evaluated.Cure：Body temperature is normal, and various symptoms disappear.Take a turn for the better：
Body temperature is normal, and various symptoms mitigate.Do not heal：Heating is not moved back or increased, and nasal obstruction runny nose and simultaneous disease do not improve or aggravate.
3. 2 treatment results
After being treated through 3 d, two groups of comparitive studies, difference has conspicuousness（P<0.01）.It is shown in Table 1.
1 two groups of comparitive studies of table（Example（%））
| Group | Number of cases | Recovery from illness | Take a turn for the better | It is invalid | Total effective rate（%） |
| Control group | 22 | 9 | 8 | 5 | 77.27 |
| Observation group | 23 | 12 | 10 | 1 | 95.65* |
Compare with control group, * P<0.01.
Claims (8)
1. a kind of pharmaceutical composition for preventing and treating cold in children, it is characterised in that be made the bulk drug of the pharmaceutical composition composition and
Weight portion is：
The auriculate dichrocephala herb or leaf 220-226 weight portion sickle calyx small pigeon-wheat 210-214 weight portions plateau fleas of calanthe 230-238 weight portions
Sew 130-134 weight portion lady's-grass 110-112 weight portions.
2. a kind of pharmaceutical composition for preventing and treating cold in children according to claim 1, it is characterised in that be made the drug regimen
The composition and weight portion of the bulk drug of thing be：
The small weight portion of 212 weight portion plateau sandwort of pigeon-wheat 132 of the weight portion of 223 weight portion sickle calyx calanthe of auriculate dichrocephala herb or leaf 234
The weight portion of lady's-grass 111.
3. a kind of pharmaceutical composition for preventing and treating cold in children according to claim 1, it is characterised in that pharmaceutical composition can be with
Piece agent or capsule or dripping pill are prepared using the conventional method of galenic pharmacy.
4. a kind of pharmaceutical composition for preventing and treating cold in children according to claim 1, it is characterised in that pharmaceutical composition with change
What medicine or Chinese medicine were constituted prevents and treats cold in children medicine.
5. a kind of preparation method of the pharmaceutical composition for preventing and treating cold in children, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：The auriculate dichrocephala herb or leaf 220-226 weight portion sickle calyx calanthe small golden hairs of 230-238 weight portions
Moss 210-214 weight portions plateau sandwort 130-134 weight portion lady's-grass 110-112 weight portions；
Preparation method：
（1）Auriculate dichrocephala herb or leaf, sickle calyx calanthe, small pigeon-wheat, plateau sandwort, lady's-grass are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 32% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 26 times, and each extraction time is 54 hours, every time
Solvent load is 18 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative
Density 1.06, filtration, liquid is first washed with water by NKA-9 large pore resin absorption columns, then with the second of weight percent concentration 14%
Alcoholic solution elutes NKA-9 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 14%, reclaims ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 43% as solvent, heating and refluxing extraction 17 times is carried every time
The time is taken for 0.3 hour, each solvent load is 22 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.13 is concentrated into, filtered, liquid is first washed with water by SP825 large pore resin absorption columns, then with again
Amount percent concentration 67% ethanol solution wash-out SP825 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 67%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition for preventing and treating cold in children according to claim 5, it is characterised in that by such as
It is prepared by lower step：
The composition and weight portion of bulk drug be：The small weight of pigeon-wheat 212 of weight portion of 223 weight portion sickle calyx calanthe of auriculate dichrocephala herb or leaf 234
The weight portion of 132 weight portion lady's-grass of amount part plateau sandwort 111；
Preparation method：
（1）Auriculate dichrocephala herb or leaf, sickle calyx calanthe, small pigeon-wheat, plateau sandwort, lady's-grass are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 32% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 26 times, and each extraction time is 54 hours, every time
Solvent load is 18 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative
Density 1.06, filtration, liquid is first washed with water by NKA-9 large pore resin absorption columns, then with the second of weight percent concentration 14%
Alcoholic solution elutes NKA-9 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 14%, reclaims ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 43% as solvent, heating and refluxing extraction 17 times is carried every time
The time is taken for 0.3 hour, each solvent load is 22 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.13 is concentrated into, filtered, liquid is first washed with water by SP825 large pore resin absorption columns, then with again
Amount percent concentration 67% ethanol solution wash-out SP825 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 67%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition for preventing and treating cold in children according to claim 5, it is characterised in that medicine
Composition can prepare piece agent or capsule or dripping pill using the conventional method of galenic pharmacy.
8. a kind of preparation method of the pharmaceutical composition for preventing and treating cold in children according to claim 5, it is characterised in that medicine
Composition prevents and treats cold in children medicine with chemical drugs or Chinese medicine composition.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611132938.4A CN106729025A (en) | 2016-12-10 | 2016-12-10 | Prevent and treat pharmaceutical composition of cold in children and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611132938.4A CN106729025A (en) | 2016-12-10 | 2016-12-10 | Prevent and treat pharmaceutical composition of cold in children and preparation method thereof |
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| Publication Number | Publication Date |
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| CN106729025A true CN106729025A (en) | 2017-05-31 |
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ID=58879445
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611132938.4A Withdrawn CN106729025A (en) | 2016-12-10 | 2016-12-10 | Prevent and treat pharmaceutical composition of cold in children and preparation method thereof |
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| Country | Link |
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| CN (1) | CN106729025A (en) |
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2016
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Application publication date: 20170531 |