CN106727851A - Prevent and treat pharmaceutical composition of ovarian cyst and preparation method thereof - Google Patents
Prevent and treat pharmaceutical composition of ovarian cyst and preparation method thereof Download PDFInfo
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Abstract
Pharmaceutical composition of ovarian cyst and preparation method thereof is prevented and treated the invention discloses a kind of, pharmaceutical composition of the present invention is with moth tree, Strobilanthes aehobarbus W. W. Smith, plateau sandwort, streamwort, native Jehol Ligusticum Rhizome as bulk drug, proportioning is formed, routinely various formulations can be made by preparation process, prevent and treat ovarian cyst evident in efficacy.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of pharmaceutical composition for preventing and treating ovarian cyst and its preparation side
Method.
Background technology
This disease belongs to traditional Chinese medical science abdominal mass category, and disease person, the hard knot of its block is not dissipated, and fixation is not moved, fixed pain;Lump in the abdomen person, gathers scattered nothing
Often, what is pushed away removable, migratory pain.《Gynaecology's jade chi》Cloud:" abdominal mass person, married woman suffers from this, about all viviparous product of born of the same parents, moon water contacts, blood
Arteries and veins vital essence is uncomfortable and eating and drinking without temperance, taste are lost, evil positive is invaded, institute of the product in abdomen is raw ".The author thinks, though this disease do not belong to warp,
The sick category of band, tire, product, but have substantial connection with female pathology, pathological characteristic.Predominantly postpartum or pass through accidentally, invaded in exopathogen
Or the tangible heresy obstruction train of thought such as seven feelings diet, internal injury, visceral dysfunction, mechanism of qi retardance, phlegm and retained fluid, hemostasis, stop product in underbelly,
Accumulate in the course of time increase, it is abdominal mass to send out.Its treatment is with softening and resolving hard mass, product of assaulting fortified position brokenly as method.Ovarian cyst is common gynecological disease, main hair
Sick colony is breeding time women, and its clinical onset rate is about 5%, and epidemiological investigation shows current China's ovarian cyst disease
Suffer from about 6,000,000 person-times.Clinic is mainly expectant treatment and operative treatment for the treatment method of the disease, and medical conservative therapy is controlled
Treatment can exempt sense of discomfort and the risk that patient is triggered by surgical operation, but simple western medicine expectant treatment scheme was often in the past
Satisfied therapeutic effect cannot be obtained.
Streamwort:Haloragaceae seaberry streamwort Haloragis micrantha
(Thunb.) herb of R.Br.ex Sidb. Et Zucc. [Goniocarpus micranthus Thunb.].Summer harvests
Herb, cleans, and dries.【Nature and flavor】Bitter;It is puckery;It is cool in nature.【Return through】Return lung;Large intestine;Bladder;It is nontoxic.【Indication】Cough-relieving is put down
Breathe heavily;Clearing heat and promoting diuresis;Regulating menstruation and activating blood.Main cough;Asthma;Heat gonorrhea;Constipation;Dysentery;Irregular menstruation;Fall damage fracture;Furunculosis;Acute mastitis;
Scald;Venomous snake bite.【Former phytomorph】Perennial slim and frahile draft, grows thickly, 20-40cm high.The prismatic of stem four, band russet, directly
Vertical, base portion is crawled branch.Leaf is small, has short handle, opposite, and stem upper leaf is alternate sometimes;The usual egg shape or circular shape of blade, 6- long
10cm, 4-8mm wide, tip is short sharp or blunt, and there is a small tooth at edge, basal circular, and two sides is bald net, light green or puce.Circular cone
Inflorescence basidixed, is made up of thin raceme;Spend small, both sexes;Calyx pipe has rib, and sliver 4, triangle is harbored;Petal 4, it is red;
Stamen 8, flower pesticide aubergine;Gynoecium 1;Ovary is the next, has ratio rib, and style 4, the pink hair of the close life of column cap, drupe is subsphaeroidal,
Be about 1mm, it is bald will and it is bright, have 8 ribs.The month at florescence 6-7, the fruiting period 9-10 months.Record in dictionary of medicinal plant.
Moth tree:Pueraria lobota trailing plants maple Acer grosseri Pax var.hersii are split for Aceraceae Acer plants are long(Rehd.)
Rehd. the spray and fruit of [ A.hersii Rehd. ].9-10 month picking fruits, dry;The 6-7 months harvest spray, dry.【Property
Taste】It is bitter;It is salty;It is flat.【Indication】Cough-relieving;Sore.The new chronic cough of master is coughed;Thrush.【Original shape state】It is tall that length splits Pueraria lobota trailing plants maple fallen leaves
Wood, up to 8m.Bark is filbert, smooth;Annual shoot green or purple green, perennial branch lark or taupe, leaf opposite;
Petiole 2-3cm long, it is thin thin, without hair;Blade papery, avette, 7-9cm long, 5-6cm wide, edge has close and sharp heavy sawtooth, first
Hold sharp point, base portion to be bordering on heart-shaped, often deeper 3 and split, central sliver is larger, and triangular shape is avette, above bottle green, without hair;Under
Face light green, is then come off always in vein base portion when tender by faint yellow feathering;Base goes out 3, arteries and veins, lateral vein pinniform.Flower unisexuality, male and female are different
Strain, often into thin thin sagging raceme;Sepal 5;Petal 5;Stamen 8, without hair, the agensis in female flower;Floral disc is located at stamen
Inner side;Ovary purple, the agensis in male flower.Bennet 3-4mm long.Lavender, ripe rear yellowish-brown during samara children;Pyrene is micro- flat
Flat, together with pyrene 2.5-2.9cm long, about 5mm wide or is bordering on level at flare up obtuse angle to wing.April at florescence, fruiting period September.Record
In dictionary of medicinal plant.
Strobilanthes aehobarbus W. W. Smith:It is Acanthaceae kalimeris platymiscium capillary copper purple cloud dish Strobilanthes aehobarbus W. W.
The root and leaf of Smith.Root, leaf whole year can adopt, and clean, and dry.【Nature and flavor】It is lightly seasoned;Slight bitter;It is mild-natured.【Return through】The heart;Lung;Liver
Through.【Indication】Clearing liver dampness removing;Promoting blood circulation to remove blood stasis.Main jaundice with damp-heat pathogen;Red eye, swell pain;Irregular menstruation;Postpartum abdominal pain.【Former plant
Form】The capillary copper purple cloud perennial shrub shape draft of dish, about 1m high.Stem is upright, multi-branched, the prismatic of top four, and section expands, flat
It is flat, it is close by brown color undercoat, it is miscellaneous to have white pubescence long, it is especially close with browse hair.Single leaf opposite;There is handle;Blade oval or ovum
Shape, tip is tapering, and base portion is slightly asymmetric, blunt circle or heart, and side tool dredges crenation, above sunlight green, below mulberry, two sides quilt
Brown color undercoat and white become mildewed, in blueness after hair such as wiping is de- on branches and leaves.Spike basidixed or axillary;Bract is lobate;Calyx 5
Split;Flower purple;Corolla tubular, tip 5 splits, two lips;Stamen 4, the last two, filigree base portion has river film quality to be connected, and corolla inner face has 2
Row undercoat.Capsule.There is 4, seed.Record in dictionary of medicinal plant.
Native Jehol Ligusticum Rhizome:This product is the dry aerial parts of samphire skirret Sium suave Walt..Cut between 8~October
Aerial part is taken, is dried.【Nature and flavor】Sweet, bitter, cold.【Function with cure mainly】Calming liver and clearing heat, expelling wind and removing dampness.For hypertension, dizziness
Headache, blood strangury.【Proterties】Stem cylinder, 0.3~1.5cm of diameter, section is obvious, has root trace below nearly base portion section;Surface is dark brown
Color, brown or green, there is most straight grain and rib ridge;Matter heavily fortified point is crisp, plane of rupture edge yellow, fibroid, and there is big shape cavity centre.
The many shrinkage curlings of blade, some blades are broken only to remain petiole, and in a tubular form, base portion embraces stem into sheath shape.It is a plumage after blade flattening
Shape compound leaf, sliver lanceolar, edge tool sawtooth.Leaf has faint scent, lightly seasoned.Record in (the Shanghai of Shanghai City Chinese medicine standard 1994
Municipal health bureau).
Plateau sandwort:This product is pinkwort plateau sandwort Arenaria przewalskii Maxim. and its belongs to together
Various plants dry herb.7~August gathers herb, cleans soil, dries.【Nature and flavor】Sweet, bitter, cold.【Function with cure mainly】Clearly
Hot profit lung.For pneumonia, pulmonary tuberculosis, the disease such as lung heat cough and asthma.【Proterties】This product is often crimped to bulk.Root dark brown, yellowish-brown is main
Root woody part white.Stem foot harbors the withered leaf sheath of threadiness, and close by filbert glandular hairs.Blade is linear to lanceolar, and base portion is wider,
Joint is into sheath, and middle rib is obvious.Flower basidixed, crushes more, launches visible bract green, ovate-elliptic, by glandular hairs;Sepal is pale purple
Color;Petal is fallow (being white when fresh).Gas is micro-, taste micro-sweet, hardship.Record and issue Tibetan medicine standard in the Ministry of Public Health(First), mark
Quasi- numbering:WS3-BC-0084-95.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of pharmaceutical composition for effectively preventing and treating ovarian cyst
And preparation method thereof.
The present invention adopts the following technical scheme that realization:
The composition and weight portion for being made the bulk drug of the pharmaceutical composition for preventing and treating ovarian cyst be:
Moth tree 306-310 weight portion Strobilanthes aehobarbus W. W. Smith 282-288 weight portions plateau sandwort 10-14 weight portion streamworts
162-164 weight portions soil Jehol Ligusticum Rhizome 60-62 weight portions.
The pharmaceutical composition for preventing and treating ovarian cyst is preferably used in, is made up of the bulk drug of following weight portion:
The weight portion soil ligusticumic of 308 weight portion Strobilanthes aehobarbus W. W. Smith of moth tree, 285 12 weight portion streamwort of weight portion plateau sandwort 163
This 61 weight portion.
A kind of pharmaceutical composition for preventing and treating ovarian cyst, it is characterised in that pharmaceutical composition can be using the routine of galenic pharmacy
Method prepares piece agent or capsule or dripping pill.
A kind of pharmaceutical composition for preventing and treating ovarian cyst, it is characterised in that pharmaceutical composition is constituted with chemical drugs or Chinese medicine
Prevent and treat ovarian cyst medicine.
A kind of preparation method of the pharmaceutical composition for preventing and treating ovarian cyst, it is characterised in that prepare as follows:
The composition and weight portion of bulk drug be:Moth tree 306-310 weight portion Strobilanthes aehobarbus W. W. Smith 282-288 weight portions plateau sandwort
10-14 weight portion streamwort 162-164 weight portions soil Jehol Ligusticum Rhizome 60-62 weight portions;
Preparation method:
(1)Moth tree, Strobilanthes aehobarbus W. W. Smith, plateau sandwort, streamwort, native Jehol Ligusticum Rhizome are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 28% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 16 times, and each extraction time is 35 hours, every time
Solvent load is 40 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative
Density 1.16, filtration, liquid is first washed with water by D3520 large pore resin absorption columns, then with the second of weight percent concentration 23%
Alcoholic solution elutes D3520 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 23%, reclaims ethanol, and concentration is dry
It is dry, obtain final product extract A;
(2)Take step(1)Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 30 times is carried every time
The time is taken for 0.5 hour, each solvent load is 45 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water, then use by HC-ADS-7 large pore resin absorption columns
The ethanol solution of weight percent concentration 77% elutes HC-ADS-7 large pore resin absorption columns, collects the ethanol of weight percent concentration 77%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B;
(3)Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition for preventing and treating ovarian cyst, it is characterised in that make as follows
It is standby:
The composition and weight portion of bulk drug be:The weight portion of 308 weight portion Strobilanthes aehobarbus W. W. Smith of moth tree, 285 weight portion plateau sandwort 12
The weight portion of the streamwort 163 soil weight portion of Jehol Ligusticum Rhizome 61;
Preparation method:
(1)Moth tree, Strobilanthes aehobarbus W. W. Smith, plateau sandwort, streamwort, native Jehol Ligusticum Rhizome are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 28% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 16 times, and each extraction time is 35 hours, every time
Solvent load is 40 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative
Density 1.16, filtration, liquid is first washed with water by D3520 large pore resin absorption columns, then with the second of weight percent concentration 23%
Alcoholic solution elutes D3520 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 23%, reclaims ethanol, and concentration is dry
It is dry, obtain final product extract A;
(2)Take step(1)Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 30 times is carried every time
The time is taken for 0.5 hour, each solvent load is 45 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water, then use by HC-ADS-7 large pore resin absorption columns
The ethanol solution of weight percent concentration 77% elutes HC-ADS-7 large pore resin absorption columns, collects the ethanol of weight percent concentration 77%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B;
(3)Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for preventing and treating ovarian cyst, it is characterised in that pharmaceutical composition can be using system
The conventional method of agent prepares piece agent or capsule or dripping pill.
A kind of preparation method of the pharmaceutical composition for preventing and treating ovarian cyst, it is characterised in that pharmaceutical composition and chemical drugs or
Chinese medicine composition prevents and treats ovarian cyst medicine.
It is evident in efficacy that pharmaceutical composition prevents and treats ovarian cyst.
Specific embodiment
Embodiment 1:Prevent and treat pharmaceutical composition of ovarian cyst and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of ovarian cyst be:Moth tree 308g Strobilanthes aehobarbus W. W. Smiths 285g
The native Jehol Ligusticum Rhizome 61g of plateau sandwort 12g streamworts 163g;
Preparation method:
(1)Moth tree, Strobilanthes aehobarbus W. W. Smith, plateau sandwort, streamwort, native Jehol Ligusticum Rhizome are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 28% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 16 times, and each extraction time is 35 hours, every time
Solvent load is 40 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative
Density 1.16, filtration, liquid is first washed with water by D3520 large pore resin absorption columns, then with the second of weight percent concentration 23%
Alcoholic solution elutes D3520 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 23%, reclaims ethanol, and concentration is dry
It is dry, obtain final product extract A;
(2)Take step(1)Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 30 times is carried every time
The time is taken for 0.5 hour, each solvent load is 45 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water, then use by HC-ADS-7 large pore resin absorption columns
The ethanol solution of weight percent concentration 77% elutes HC-ADS-7 large pore resin absorption columns, collects the ethanol of weight percent concentration 77%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B;
(3)Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2:Prevent and treat pharmaceutical composition of ovarian cyst and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of ovarian cyst be:Moth tree 306g Strobilanthes aehobarbus W. W. Smiths 288g
The native Jehol Ligusticum Rhizome 60g of plateau sandwort 10g streamworts 164g;
Preparation method:
(1)Moth tree, Strobilanthes aehobarbus W. W. Smith, plateau sandwort, streamwort, native Jehol Ligusticum Rhizome are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 28% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 16 times, and each extraction time is 35 hours, every time
Solvent load is 40 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative
Density 1.16, filtration, liquid is first washed with water by D3520 large pore resin absorption columns, then with the second of weight percent concentration 23%
Alcoholic solution elutes D3520 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 23%, reclaims ethanol, and concentration is dry
It is dry, obtain final product extract A;
(2)Take step(1)Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 30 times is carried every time
The time is taken for 0.5 hour, each solvent load is 45 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water, then use by HC-ADS-7 large pore resin absorption columns
The ethanol solution of weight percent concentration 77% elutes HC-ADS-7 large pore resin absorption columns, collects the ethanol of weight percent concentration 77%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B;
(3)Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3:Prevent and treat pharmaceutical composition of ovarian cyst and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of ovarian cyst be:Moth tree 310g Strobilanthes aehobarbus W. W. Smiths 282g
The native Jehol Ligusticum Rhizome 62g of plateau sandwort 14g streamworts 162g;
Preparation method:
(1)Moth tree, Strobilanthes aehobarbus W. W. Smith, plateau sandwort, streamwort, native Jehol Ligusticum Rhizome are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 28% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 16 times, and each extraction time is 35 hours, every time
Solvent load is 40 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative
Density 1.16, filtration, liquid is first washed with water by D3520 large pore resin absorption columns, then with the second of weight percent concentration 23%
Alcoholic solution elutes D3520 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 23%, reclaims ethanol, and concentration is dry
It is dry, obtain final product extract A;
(2)Take step(1)Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 30 times is carried every time
The time is taken for 0.5 hour, each solvent load is 45 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water, then use by HC-ADS-7 large pore resin absorption columns
The ethanol solution of weight percent concentration 77% elutes HC-ADS-7 large pore resin absorption columns, collects the ethanol of weight percent concentration 77%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B;
(3)Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4:The preparation of tablet
The pharmaceutical composition 240g of Example 1, adds starch 169g, mixes, and granulation is dried, plus microcrystalline cellulose 63g, stearic
Sour magnesium 5g, mixes, and is pressed into 1500, obtains final product medicinal composition tablets.
Embodiment 5:The preparation of capsule
The pharmaceutical composition 154g of Example 2, adds starch 267g, mixes, and granulation is dried, whole grain, adds appropriate stearic acid
Magnesium, mixes, and encapsulated 980, obtains final product medicament composition capsule.
Embodiment 6:The preparation of dripping pill
Weigh (80 DEG C) heating of Macrogol 6000 189g water-baths and boil molten, add the pharmaceutical composition 10g of embodiment 3, fully stir
Mix uniform, with atoleine as cooling agent, put glass tube(4*80cm)In, chilling temperature is 6 DEG C, and drip internal-and external diameter is 7.0/
2.0 (mm/mm), drip is 2.2cm away from liquid level, and drop speed is optimum condition with every point 46 drop, and the cold of dripping pill surface is blotted with cotton
Solidifying agent, obtains final product medicament composition dropping pills.
Embodiment 7:Prevent and treat the pharmaceutical composition of ovarian cyst
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of ovarian cyst be:
The weight portion of 8 weight portion streamwort of plateau sandwort, 180 weight portion Strobilanthes aehobarbus W. W. Smith 290.
Embodiment 8:Prevent and treat the pharmaceutical composition of ovarian cyst
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of ovarian cyst be:
The weight portion of 12 weight portion streamwort of the plateau sandwort 150 soil weight portion of Jehol Ligusticum Rhizome 60.
Embodiment 9:Prevent and treat the pharmaceutical composition of ovarian cyst
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of ovarian cyst be:
The weight portion of 3.5 weight portion streamwort of the plateau sandwort 140 soil weight portion of Jehol Ligusticum Rhizome 70.
Experimental example 1:Prevent and treat the experimental study of ovarian cyst
1 data and method
1.1 physical data
44 ovarian cyst patients are this city hospital in July, 2013 in September, 2014 and are accepted for medical treatment in this research, and all patients are equal
Meet the clinical criteria of ovarian cyst, be unsubstantiality enclosed mass and lump diameter is in below 5cm, case clinical symptoms
Mainly include belly and lumbosacral region distending pain, menstrual disorder etc., malignant change is excluded through tumor markers inspection etc..At random by sample
Originally it is divided into treatment group and each 22 of control group, control group case age 22-43 Sui, averagely(38.4±4.1)Year, the course of disease 3 months-
2 years, averagely(7.4±2.5)Individual month, married 15,9 are given birth to;Treatment group's case age 22-43 Sui, averagely(38.2±
3.9)Year, the course of disease -2 years 3 months, averagely(7.5±2.6)Individual month, married 15,9 are given birth to.Two groups of sample standard deviations are prohibited without medication
Avoid disease and basic document compares no difference of science of statistics(P>0.05), with comparativity.
1.2 treatment methods
Control group patient is treated using simple western medicine, and treatment group increases treatment by Chinese herbs scheme on this basis, and specific method is such as
Under.
1. western medicine:From Metronidazule injection(Jiangsu Chenpai Pharmaceutical Co., Ltd, lot number:Chinese medicines quasi-word
H32021948), instiled with the dose intravenous of 7.5mg/kg, one time a day;Benzylpenicillin sodium for injection(Shanxi Dong Taisheng pharmacy of shaking has
Limit company, lot number:Chinese medicines quasi-word H14020377), 8,000,000 unit medicaments are injected into sodium chloride 250ml iv drips, often
Day 1 time, sustained medication 2 weeks.
2. treatment by Chinese herbs:Using pharmaceutical composition(The pharmaceutical composition of embodiment 1)Carry out oral medication, each 0.6g, often
Day 3 times, SM 3 weeks.
1.3 observation index and criterion of therapeutical effect
Respectively two groups of cases are carried out with the detection of follicle-stimulating hormone (FSH) and estradiol level before and after treatment, and is suffered from as Standard Judgement
Person's ovarian function improvement.
Criterion of therapeutical effect is:
1. cure:All symptoms all disappear after treatment, find that ovary Intramedullary Cysts are wholly absent after ultrasound diagnosis;
2. it is effective:Symptom is clearly better after treatment, finds that ovary Intramedullary Cysts volume reduces more than 60% after ultrasound diagnosis;
3. it is effective:Symptom takes a turn for the better after treatment, and B ultrasonic display cyst volumes reduce 20%-60%;
4. it is invalid:Standard is not up to treated above.
1.4 statistical methods
Using SPSS15.0 statistics softwares, measurement data is checked with t values, and enumeration data is with Chi-square Test, P<0.05 is to deposit
In statistical significance.
2 results
2.1 two groups of patient outcomes compare
Treatment group patient total effective rate is 95.45%, hence it is evident that be better than control group, with statistical significance(P<0.05), it is shown in Table 1.
Table 1 two groups of patient outcomes compare
Group | n | Cure | It is effective | Effectively | It is invalid | Total effective rate |
Treatment group | 22 | 7 | 9 | 5 | 1 | 95.45* |
Control group | 22 | 5 | 7 | 6 | 4 | 81.82 |
Note:Compare with control group, * P<0.05.
Assay compares before and after 2.2 two groups of patient's treatments
Follicle-stimulating hormone (FSH) compares no difference of science of statistics with estradiol level between group before treatment, and treatment group is better than control after treatment
Group, with statistical significance(P<0.05), it is shown in Table 2.
Assay compares before and after 2 two groups of patient's treatments of table
Note:Compare with control group, * P<0.05.
Claims (8)
1. a kind of pharmaceutical composition for preventing and treating ovarian cyst, it is characterised in that be made the bulk drug of the pharmaceutical composition composition and
Weight portion is:
Moth tree 306-310 weight portion Strobilanthes aehobarbus W. W. Smith 282-288 weight portions plateau sandwort 10-14 weight portion streamworts
162-164 weight portions soil Jehol Ligusticum Rhizome 60-62 weight portions.
2. a kind of pharmaceutical composition for preventing and treating ovarian cyst according to claim 1, it is characterised in that be made the drug regimen
The composition and weight portion of the bulk drug of thing be:
The weight portion soil ligusticumic of 308 weight portion Strobilanthes aehobarbus W. W. Smith of moth tree, 285 12 weight portion streamwort of weight portion plateau sandwort 163
This 61 weight portion.
3. a kind of pharmaceutical composition for preventing and treating ovarian cyst according to claim 1, it is characterised in that pharmaceutical composition can be with
Piece agent or capsule or dripping pill are prepared using the conventional method of galenic pharmacy.
4. a kind of pharmaceutical composition for preventing and treating ovarian cyst according to claim 1, it is characterised in that pharmaceutical composition with change
What medicine or Chinese medicine were constituted prevents and treats ovarian cyst medicine.
5. a kind of preparation method of the pharmaceutical composition for preventing and treating ovarian cyst, it is characterised in that prepare as follows:
The composition and weight portion of bulk drug be:Moth tree 306-310 weight portion Strobilanthes aehobarbus W. W. Smith 282-288 weight portions plateau sandwort
10-14 weight portion streamwort 162-164 weight portions soil Jehol Ligusticum Rhizome 60-62 weight portions;
Preparation method:
(1)Moth tree, Strobilanthes aehobarbus W. W. Smith, plateau sandwort, streamwort, native Jehol Ligusticum Rhizome are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 28% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 16 times, and each extraction time is 35 hours, every time
Solvent load is 40 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative
Density 1.16, filtration, liquid is first washed with water by D3520 large pore resin absorption columns, then with the second of weight percent concentration 23%
Alcoholic solution elutes D3520 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 23%, reclaims ethanol, and concentration is dry
It is dry, obtain final product extract A;
(2)Take step(1)Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 30 times is carried every time
The time is taken for 0.5 hour, each solvent load is 45 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water, then use by HC-ADS-7 large pore resin absorption columns
The ethanol solution of weight percent concentration 77% elutes HC-ADS-7 large pore resin absorption columns, collects the ethanol of weight percent concentration 77%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B;
(3)Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition for preventing and treating ovarian cyst according to claim 5, it is characterised in that by such as
It is prepared by lower step:
The composition and weight portion of bulk drug be:The weight portion of 308 weight portion Strobilanthes aehobarbus W. W. Smith of moth tree, 285 weight portion plateau sandwort 12
The weight portion of the streamwort 163 soil weight portion of Jehol Ligusticum Rhizome 61;
Preparation method:
(1)Moth tree, Strobilanthes aehobarbus W. W. Smith, plateau sandwort, streamwort, native Jehol Ligusticum Rhizome are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 28% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 16 times, and each extraction time is 35 hours, every time
Solvent load is 40 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative
Density 1.16, filtration, liquid is first washed with water by D3520 large pore resin absorption columns, then with the second of weight percent concentration 23%
Alcoholic solution elutes D3520 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 23%, reclaims ethanol, and concentration is dry
It is dry, obtain final product extract A;
(2)Take step(1)Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 30 times is carried every time
The time is taken for 0.5 hour, each solvent load is 45 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water, then use by HC-ADS-7 large pore resin absorption columns
The ethanol solution of weight percent concentration 77% elutes HC-ADS-7 large pore resin absorption columns, collects the ethanol of weight percent concentration 77%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B;
(3)Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition for preventing and treating ovarian cyst according to claim 5, it is characterised in that medicine
Composition can prepare piece agent or capsule or dripping pill using the conventional method of galenic pharmacy.
8. a kind of preparation method of the pharmaceutical composition for preventing and treating ovarian cyst according to claim 5, it is characterised in that medicine
Composition prevents and treats ovarian cyst medicine with chemical drugs or Chinese medicine composition.
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CN201611132914.9A CN106727851A (en) | 2016-12-10 | 2016-12-10 | Prevent and treat pharmaceutical composition of ovarian cyst and preparation method thereof |
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2016
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