CN106728467A - A kind of pharmaceutical composition for preventing and treating climacteric metancholia - Google Patents
A kind of pharmaceutical composition for preventing and treating climacteric metancholia Download PDFInfo
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Abstract
Pharmaceutical composition of climacteric metancholia and preparation method thereof is prevented and treated the invention discloses a kind of, pharmaceutical composition of the present invention is with Chinese viburnum stem, three-jaw gold dragon, Eurya plant wood, β irisones, euparotin, golden wave chalcone as bulk drug, proportioning is formed, routinely various formulations can be made by preparation process, prevent and treat climacteric metancholia evident in efficacy.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of pharmaceutical composition and its system for preventing and treating climacteric metancholia
Preparation Method.
Background technology
Menopausal syndrome is the common disease before and after menopausal women, motherland's medical science can belong to " palpitaition ", " insomnia ",
The illness category such as " dizziness ", " dirty dry ", " irregular menstruation ".Menopause praecox of this disease before visible 40 years old, or the evening after 55 years old
Hair menopause.Bilateral oophorectomy or because of reasons such as radiotherapies, destroys ovarian function person, also may occur in which that this is demonstrate,proved.In this transition period
Most of women is perplexed by a series of light or heavy symptoms, with the extension of human longevity, the morbidity of climacteric metancholia
Rate is being gradually increasing, and influences female normal life and work, even have impact on the harmony of family.
Menopause refer to the deterioration from ovary to the postclimacteric several years, last 10 years to 20 years, period
Ovarian function falls into a decline, menstrual cycle extension, is gradually decreased through amount, most of in this transition period until stopping completely
Women is perplexed by a series of light or heavy symptoms, and severe one is possible to trigger nerve channel energy disease, or mental disease, has a strong impact on
Interpersonal relationships and normal life.Women's climacteric syndrome age of onset is 45~55 years old or so, now " seventy-seven, conception vessel is empty,
Taichong channel is declined and lacks, the menopause, menostasia, therefore shape is gone bad and s.m.p ".Imbalance of yin and yang, the visible hectic fever of hyperactivity of yang due to yin deficiency, sweating, head
Dizzy day is dizzy；Liver governing tendons, Shen controls bone, The liver and the kidney have a common source, and deficiency of kidney-QI, liver blood is also empty, it is seen that muscles and bones is ached, pain in the back；Kidney qi is deficient, body
Interior aqueous can not evaporate, in addition insufficiency of the spleen transporting mistake department, water-damp not being transformed, gather and raw phlegm；Climacteric emotional instability, liver dysfunction,
Stagnant heat in the liver and gall, courage stomach discord, the hot pent-up of phlegm, " all kinds of diseases and ailments are haunted by phlegm more ", type of phlegm-heat attacking the heart then receive by vexed palpitaition, insomnia and dreamful sleep, hardship
Difference, just the disease such as dry Huang of urinating, red yellow tongue fur, stringy,thready and rapid pulse, belong to the deficiency of liver-yin and kidney-yin, stasis blocking mechanism of qi, hot and suffocating to pent up.
Chinese viburnum stem：It is the stem of Caprifoliaceae Viburnum plant silk ball Jia Opulus Viburnum macrocephalum Fort..
Whole year can be harvested, and segment is dried.【Nature and flavor】Bitter；It is cool in nature.【Indication】Eliminating dampness is antipruritic.Main scabies is fresh；Wet rotten pain of itching.【Medicine
Reason is acted on】The V. macrocephalum that European and American countries were once produced with it in one's early years（Europe V. macrocephalum Viburnumopulus or U.S. V. macrocephalums
V.prunifolium）Preparation controls irregular menstruation, uterine hemorrhage, antenatal pain etc. as uterus sedative, records in American-European one
In the pharmacopeia of a little countries.V. macrocephalum contained glucoside in Europe has contraction to uterus, blood vessel；Additionally, also containing inhibition composition;
50% alcohol extracting thing effect is preferable.Fruit energy cardiac stimulant, diuresis.【Former phytomorph】Silk ball Jia Opulus fall leaves or semi-evergreen shrubs, high
Up to 4m.Sprout is considered to be worth doing by dirt and closes stellate hair, old branch grey black, and hibernaculum is without scale.Leaf opposite；Petiole 10-15mm long；Blade papery；
Leaf is avette, oval circular to ovate square, and 5-11cm long, 2.5-4.5cm wide, tip are blunt or slightly sharp, base portion circle or sometimes micro- heart
Table, edge serration, below sparsely grow stellate hair, lateral vein 5-6 pairs, before nearly leaf margin net knot, together with above middle arteries it is slightly concave fall into, lower convexity.
Cancel umbrella inflorescence diameter 8-15cm, be all made up of large-scale sterile flower；Total bennet is obvious, the 1st grade of 5 articles of radiation branch, and peanut is in the 3rd
In level radiation branch；Calyx tube tubular, is about 2.5mm, and limb has 5 micro- teeth；Corolla white, spoke shape, diameter 1.5-4cm, sliver round shape
Obovate, corolla tube is short；Stamen 5, is about 3mm；Gynoecium infertility.The month at florescence 4-5.Record in dictionary of medicinal plant.
Three-jaw gold dragon：It is Vitaceae Parthenocissus plant parthenocissus himalayana Plancs Parthenocissus himalayana
（Royle）Planch. the complete stool of ［ Ampelopsis himalayana Royle ］.Autumn, winter harvesting root and stem, cut after cleaning
Piece or segment, dry.Summer, autumn picking leaves, dry.【Nature and flavor】It is pungent；Temperature.【Indication】Dispelling wind and eliminating dampness；Dissipate blood stasis and smoothing collaterals.Main wind
Arthritis with fixed pain caused by dampness is bitterly；Traumatic injury；Fracture.【Former phytomorph】Parthenocissus himalayana Plancs fallen leaves woody climber.Multi-branched, branch is sturdy, drabon
Color；Tendril is short and branch, and there is sucker on top.The leaflet alternate of palmate 3；Common petiole 5-12cm long, without hair or hairiness；Blade papery,
Middle leaflet is avette or width drape over one's shoulders needle-like avette, 6-12cm long, 2-7cm wide, and tip is tapering or nearly shape of tail, and base portion wedge shape, side life is small
Leaf is asymmetric, tiltedly avette, compared with the middle of leaflet it is smaller, edge have substantially and the sawtooth with tip, above without hair, below or along vein
There is thin pubescence；Petiolule 5-6mm long.Flower both sexes, cyme be often born in brachyplast top or with leaf opposite；Bennet is compared with petiole
It is short；Flower light green, 5 numbers 4 are counted sometimes；Calyx shallow disc shape, full edge；Petal Long Circle；Stamen and petal opposite；Floral disc is not obvious；
Style short cylindrical shape, tip often expands discoid after petal comes off.Berry is spherical, ripe time-varying dark brown, has white powder, seed 1-2
.Record in dictionary of medicinal plant.
Eurya plant wood：It is the branches and leaves or fruit of plant of theaceae Eurya plant wood Eurya japonica Thunb..【Nature and flavor】It is bitter；It is puckery；
It is cool.【Return through】Spleen；Bladder warp.【Indication】Expelling wind and clearing away heat；Inducing diuresis for removing edema；Hemostasia and promoting granulation.Main arthralgia pain due to rheumatism；Ascites expands；
Heating dry；Sore swells；Treating swelling and pain by traumatic injury；Traumatic bleeding.【Proterties】Branch grey, hole skin substantially, there is a trace and stipe scar.Leaf breaks more
Broken, intact leaf lanceolar, 4-6cm long, 1.5-2cm wide, tip is suddenly sharp or tapering, base portion wedge shape, edge have thin crenature or
It is serrated；Surface yellow green or dirty-green, tender leaf color are light, there is pubescence, and old leaf color depth is more smooth；Keratin.Fruit is in irregular
Spherical, shrinkage, diameter 3-4mm, kermesinus or atropurpureus.Gas is micro-, mildly bitter flavor.【Chemical analysis】Given birth to containing dimension in fresh leaf
Plain C29-219mg/100g.Fruit contains Chrysanthemin（chrysanthemin）, Cyanidin 3- acetyl rutinosides
（cyanidin 3-acetylrutinodide）；Flower is containing Eurya plant wood flower glucoside（euryanoside）, the auspicious ketone of Harry（halleridone）
Carry out wooden glucoside with wood（cornoside）.【Former phytomorph】Eurya plant wood shrub, 1-3m high.Spray has rib, without hair or has thin hair.It is single
Leaf alternate；Petiole 2-5mm long；Blade leathery, into two column-shaped, oval to round shape lanceolar, 3-6cm long, 1.5-3cm wide are first
Hold sharp sharp or tapering, nick, base portion wedge shape, edge tool cognate, above bottle green, below yellow green, without hair, master pulse exists on two sides
It sink above, lateral vein is not obvious.Flower unisexuality, dioecism, normal 1-3 fasciating in axil and branch side；Bennet is short, sagging；Sepal
5, subcircular is harbored；Petal 5, white or yellow green, avette, base portion joint；The stamen of male flower is most, is shorter than petal, son of degenerating
Room with or without；Female flower is without stamen, and style is short, and tip 3 is shallow to be split.Berry spheroidal, footpath about 5mm, atropurpureus when ripe.Florescence 3-4
Month, the fruiting period 7-8 months.Record in dictionary of medicinal plant.
Alpha, beta-lonone（Irisone）：CAS 14901-07-6, molecular formula C13H20O, molecular weight 192.30.【Biology is living
Property】Spices.【Ingredient origin】Almond Prunus armeniaca, banksia rose Saussurea lappa [Syn.Aucklandia
Lappa], fruit of Chinese wolfberry Lycium chinense.
Euparotin（Euparotin）：CAS 10191-01-2, molecular formula C20H24O7, molecular weight 376.41.【It is biological
Activity】It is antitumor；Cell toxicant (KB, ED50=0.21 μ g/ml).【Ingredient origin】Roundleaf Herba Lycopi Eupatorium
rotundifolium。
Golden wave chalcone（Okanin ）：CAS 484-76-4, molecular formula C15H12O6, molecular weight 288.26.【Pharmacology is made
With】Uranidin.【Ingredient origin】In composite family golden pheasant Chrysanthemum and Bidens plant chrysanthemum.
3 chemical constitutions of bulk drug：
Euparotin（Euparotin）Alpha, beta-lonone（Irisone）
Golden wave chalcone（Okanin ）.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of medicine group for effectively preventing and treating climacteric metancholia
Compound and preparation method thereof.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for being made the bulk drug of the pharmaceutical composition for preventing and treating climacteric metancholia be：
Chinese viburnum stem 4800-4900 weight portions three-jaw gold dragon 50-80 weight portions Eurya plant wood 3500-3700 weight portions β-violet
Ketone 40-70 weight portion euparotin 100-110 weight portion golden wave chalcone 60-70 weight portions.
The pharmaceutical composition for preventing and treating climacteric metancholia is preferably used in, is made up of the bulk drug of following weight portion：
The imperial 65 weight portion Eurya plant wood 3600 weight portion alpha, beta-lonone 60 weight portion pool of the weight portion three-jaw of Chinese viburnum stem 4850 gold
The weight portion of 105 weight portion golden wave chalcone of blue amarolide 65.
A kind of pharmaceutical composition for preventing and treating climacteric metancholia, it is characterised in that pharmaceutical composition can be using galenic pharmacy
Conventional method prepares piece agent or capsule or dripping pill.
A kind of pharmaceutical composition for preventing and treating climacteric metancholia, it is characterised in that pharmaceutical composition and chemical drugs or Chinese medicine group
Into prevent and treat climacteric metancholia medicine.
A kind of preparation method of the pharmaceutical composition for preventing and treating climacteric metancholia, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Chinese viburnum stem 4800-4900 weight portions three-jaw gold dragon 50-80 weight portions Eurya plant wood
3500-3700 weight portion alpha, beta-lonone 40-70 weight portion euparotin 100-110 weight portion golden wave chalcone 60-
70 weight portions；
Preparation method：
（1）Three-jaw gold dragon, Eurya plant wood, Chinese viburnum stem, alpha, beta-lonone, euparotin, golden wave are taken by bulk drug proportioning look into ear
Ketone, mixes, and with the ethanol of weight percent concentration 44% as solvent, is taken in 29 DEG C of temperature extractions, and extraction time is 13 times, is carried every time
The time is taken for 53 hours, each solvent load is 68 times of bulk drug gross weight, and filtration obtains dregs of a decoction A and extract solution A, extract solution A
Ethanol is reclaimed, relative density 1.16 is concentrated into, filtered, liquid is first washed with water by XAD1600 large pore resin absorption columns, then
XAD1600 large pore resin absorption columns are eluted with the ethanol solution of weight percent concentration 37%, the second of weight percent concentration 37% is collected
Alcohol eluen, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 55% as solvent, heating and refluxing extraction 27 times is carried every time
The time is taken for 0.1 hour, each solvent load is 39 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.06 is concentrated into, filtered, liquid is first washed with water, then use by GDX-501 large pore resin absorption columns
The ethanol solution of weight percent concentration 77% elutes GDX-501 large pore resin absorption columns, collects the ethanol of weight percent concentration 77%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition for preventing and treating climacteric metancholia, it is characterised in that as follows
Prepare：
The composition and weight portion of bulk drug be：The weight portion three-jaw of Chinese viburnum stem 4850 gold 3600 weight portions of imperial 65 weight portion Eurya plant wood
The weight portion of 60 weight portion euparotin of alpha, beta-lonone, 105 weight portion golden wave chalcone 65；
Preparation method：
（1）Three-jaw gold dragon, Eurya plant wood, Chinese viburnum stem, alpha, beta-lonone, euparotin, golden wave are taken by bulk drug proportioning look into ear
Ketone, mixes, and with the ethanol of weight percent concentration 44% as solvent, is taken in 29 DEG C of temperature extractions, and extraction time is 13 times, is carried every time
The time is taken for 53 hours, each solvent load is 68 times of bulk drug gross weight, and filtration obtains dregs of a decoction A and extract solution A, extract solution A
Ethanol is reclaimed, relative density 1.16 is concentrated into, filtered, liquid is first washed with water by XAD1600 large pore resin absorption columns, then
XAD1600 large pore resin absorption columns are eluted with the ethanol solution of weight percent concentration 37%, the second of weight percent concentration 37% is collected
Alcohol eluen, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 55% as solvent, heating and refluxing extraction 27 times is carried every time
The time is taken for 0.1 hour, each solvent load is 39 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.06 is concentrated into, filtered, liquid is first washed with water, then use by GDX-501 large pore resin absorption columns
The ethanol solution of weight percent concentration 77% elutes GDX-501 large pore resin absorption columns, collects the ethanol of weight percent concentration 77%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for preventing and treating climacteric metancholia, it is characterised in that pharmaceutical composition can be adopted
Piece agent or capsule or dripping pill are prepared with the conventional method of galenic pharmacy.
A kind of preparation method of the pharmaceutical composition for preventing and treating climacteric metancholia, it is characterised in that pharmaceutical composition and chemistry
Medicine or Chinese medicine composition prevent and treat climacteric metancholia medicine.
It is notable that pharmaceutical composition prevents and treats climacteric metancholia effect.
Specific embodiment
Embodiment 1：Prevent and treat pharmaceutical composition of climacteric metancholia and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of climacteric metancholia be：Chinese viburnum stem 4850g three-jaws gold
Imperial 65g Eurya plants wood 3600g alpha, beta-lonones 60g euparotin 105g golden wave chalcone 65g；
Preparation method：
（1）Three-jaw gold dragon, Eurya plant wood, Chinese viburnum stem, alpha, beta-lonone, euparotin, golden wave are taken by bulk drug proportioning look into ear
Ketone, mixes, and with the ethanol of weight percent concentration 44% as solvent, is taken in 29 DEG C of temperature extractions, and extraction time is 13 times, is carried every time
The time is taken for 53 hours, each solvent load is 68 times of bulk drug gross weight, and filtration obtains dregs of a decoction A and extract solution A, extract solution A
Ethanol is reclaimed, relative density 1.16 is concentrated into, filtered, liquid is first washed with water by XAD1600 large pore resin absorption columns, then
XAD1600 large pore resin absorption columns are eluted with the ethanol solution of weight percent concentration 37%, the second of weight percent concentration 37% is collected
Alcohol eluen, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 55% as solvent, heating and refluxing extraction 27 times is carried every time
The time is taken for 0.1 hour, each solvent load is 39 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.06 is concentrated into, filtered, liquid is first washed with water, then use by GDX-501 large pore resin absorption columns
The ethanol solution of weight percent concentration 77% elutes GDX-501 large pore resin absorption columns, collects the ethanol of weight percent concentration 77%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Prevent and treat pharmaceutical composition of climacteric metancholia and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of climacteric metancholia be：Chinese viburnum stem 4800g three-jaws gold
Imperial 80g Eurya plants wood 3500g alpha, beta-lonones 70g euparotin 100g golden wave chalcone 70g；
Preparation method：
（1）Three-jaw gold dragon, Eurya plant wood, Chinese viburnum stem, alpha, beta-lonone, euparotin, golden wave are taken by bulk drug proportioning look into ear
Ketone, mixes, and with the ethanol of weight percent concentration 44% as solvent, is taken in 29 DEG C of temperature extractions, and extraction time is 13 times, is carried every time
The time is taken for 53 hours, each solvent load is 68 times of bulk drug gross weight, and filtration obtains dregs of a decoction A and extract solution A, extract solution A
Ethanol is reclaimed, relative density 1.16 is concentrated into, filtered, liquid is first washed with water by XAD1600 large pore resin absorption columns, then
XAD1600 large pore resin absorption columns are eluted with the ethanol solution of weight percent concentration 37%, the second of weight percent concentration 37% is collected
Alcohol eluen, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 55% as solvent, heating and refluxing extraction 27 times is carried every time
The time is taken for 0.1 hour, each solvent load is 39 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.06 is concentrated into, filtered, liquid is first washed with water, then use by GDX-501 large pore resin absorption columns
The ethanol solution of weight percent concentration 77% elutes GDX-501 large pore resin absorption columns, collects the ethanol of weight percent concentration 77%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Prevent and treat pharmaceutical composition of climacteric metancholia and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of climacteric metancholia be：Chinese viburnum stem 4900g three-jaws gold
Imperial 50g Eurya plants wood 3700g alpha, beta-lonones 40g euparotin 110g golden wave chalcone 60g；
Preparation method：
（1）Three-jaw gold dragon, Eurya plant wood, Chinese viburnum stem, alpha, beta-lonone, euparotin, golden wave are taken by bulk drug proportioning look into ear
Ketone, mixes, and with the ethanol of weight percent concentration 44% as solvent, is taken in 29 DEG C of temperature extractions, and extraction time is 13 times, is carried every time
The time is taken for 53 hours, each solvent load is 68 times of bulk drug gross weight, and filtration obtains dregs of a decoction A and extract solution A, extract solution A
Ethanol is reclaimed, relative density 1.16 is concentrated into, filtered, liquid is first washed with water by XAD1600 large pore resin absorption columns, then
XAD1600 large pore resin absorption columns are eluted with the ethanol solution of weight percent concentration 37%, the second of weight percent concentration 37% is collected
Alcohol eluen, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 55% as solvent, heating and refluxing extraction 27 times is carried every time
The time is taken for 0.1 hour, each solvent load is 39 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.06 is concentrated into, filtered, liquid is first washed with water, then use by GDX-501 large pore resin absorption columns
The ethanol solution of weight percent concentration 77% elutes GDX-501 large pore resin absorption columns, collects the ethanol of weight percent concentration 77%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
The pharmaceutical composition 511g of Example 1, adds starch 522g, mixes, and granulation is dried, plus microcrystalline cellulose 160g, stearic
Sour magnesium 18g, mixes, and is pressed into 13000, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
The pharmaceutical composition 190g of Example 2, adds starch 280g, mixes, and granulation is dried, whole grain, adds appropriate stearic acid
Magnesium, mixes, and encapsulated 1300, obtains final product medicament composition capsule.
Embodiment 6：The preparation of dripping pill
Weigh (80 DEG C) heating of Macrogol 6000 243g water-baths and boil molten, add the pharmaceutical composition 9.5g of embodiment 3, fully stir
Mix uniform, with atoleine as cooling agent, put glass tube（4*80cm）In, chilling temperature is 6 DEG C, and drip internal-and external diameter is 7.0/
2.0 (mm/mm), drip is 2.0cm away from liquid level, and drop speed is optimum condition with every point 57 drop, and the cold of dripping pill surface is blotted with cotton
Solidifying agent, obtains final product medicament composition dropping pills.
Experimental example 1：Prevent and treat the experimental study of climacteric metancholia
1 data and method
1.1 clinical datas
This group 38 is this city hospital traditional chinese medical science clinic patient, wherein 40~60 years old age, the course of disease 3 months to 9 years.
1.2 clinical manifestations
There are Facial flush, hectic fever sweating, pain in the back tinnitus, dizzy limb fiber crops, palpitaition vexed insomnia, melancholy refreshing tired cardinal symptom.Examine
Disconnected standard foundation《Gynecology of Chinese Medicine》.
Method is treated in 1.3 smeltings
1.3.1 basic side's medicine
Pharmaceutical composition：The pharmaceutical composition 4g of embodiment 1.
1.3.2 medicine is added and subtracted
The obvious person of palpitation and insomnia adds Polygonum multiflower knotweed, each 10g of cortex albiziae；Dizzy substantially person adds yncaria stem with hooks 10g；Feelings will is melancholy, sad desire
The person of crying plus light wheat 20g；Enuresis nocturna more than 2 times plus Semen Cuscutae 10g, fructus alpiniae oxyphyllae 5g；The non-few person of menopause menstrual cycle amount, menstruation
Add barrenwort 8g, each 12g of the fruit of glossy privet after clean；Menostaxis plus hairyvein agrimony, cuttlebone, each 5g of charred RADIX RUBIAE.
1.3.3 instructions about how to take medicine
Daily 1 dose, decocting point is warmly taken in the afternoon and before sleeping, and 1 month is 1 course for the treatment of, and psychotherapy, regulation are added during medication
Mood, diet prohibition of life is cold, pungent fried.
2 results
2.1 criterions of therapeutical effect
It is effective：The hot sweating of Facial flush, flush, pain in the back tinnitus, dizzy palpitaition vexed insomnia, melancholy refreshing tired symptom disappear；
Effectively：Above-mentioned cardinal symptom substantially mitigates；
It is invalid：Cardinal symptom is without improvement.
2.2 treatment results
The results are shown in Table 1.
The pharmaceutical composition efficacy result of table 1
| Number of cases | It is effective | Effectively | It is invalid | Total effective rate % | |
| Treatment results | 38 | 22 | 13 | 3 | 92.11 |
Result shows that medicine composite for curing menopausal syndrome is effective, total effective rate 92.11%.
2.3 medical records are illustrated
Zhu, female, 45 years old, teacher.The first visit of May 28 in 2013, nearly 1 year of patient often feels have a dizzy spell palpitaition, memory
Decline, uneasy sleeping at night, be difficult to fall asleep, very then lie awake all night, Tidal fever with perspiration, aching pain in waist and back, dysphoria or being about to cry due to sadness, mouth
Hardship receives difference, just dry Huang of urinating.Hypomenorrhea, color it is purplish red or purple black 3~5 days it is net.Physical examination：Refreshing tired, flushed face, red tongue with yellowish fur,
Thready rapid pulse.The card category deficiency of liver-yin and kidney-yin, stasis blocking mechanism of qi is hot and suffocating to pent up.Control suitable kidney tonifying enriching yin, calming the liver, regulating qi-flowing for eliminating phlegm, heat-clearing peace
God.Using pharmaceutical composition 4g, plus Polygonum multiflower knotweed 10g, light wheat 20g.7 doses of medication, hectic fever, sweating, dizzy palpitaition etc. take a turn for the better,
Night sleeps and relatively pacify, eumenorrhea.Follow-up：Do not recurred after 1 year.
Claims (8)
1. a kind of pharmaceutical composition for preventing and treating climacteric metancholia, it is characterised in that be made the group of the bulk drug of the pharmaceutical composition
It is into weight portion：
Chinese viburnum stem 4800-4900 weight portions three-jaw gold dragon 50-80 weight portions Eurya plant wood 3500-3700 weight portions β-violet
Ketone 40-70 weight portion euparotin 100-110 weight portion golden wave chalcone 60-70 weight portions.
2. a kind of pharmaceutical composition for preventing and treating climacteric metancholia according to claim 1, it is characterised in that be made the medicine
The composition and weight portion of the bulk drug of composition be：
The imperial 65 weight portion Eurya plant wood 3600 weight portion alpha, beta-lonone 60 weight portion pool of the weight portion three-jaw of Chinese viburnum stem 4850 gold
The weight portion of 105 weight portion golden wave chalcone of blue amarolide 65.
3. a kind of pharmaceutical composition for preventing and treating climacteric metancholia according to claim 1, it is characterised in that pharmaceutical composition
Piece agent or capsule or dripping pill can be prepared using the conventional method of galenic pharmacy.
4. a kind of pharmaceutical composition for preventing and treating climacteric metancholia according to claim 1, it is characterised in that pharmaceutical composition
Climacteric metancholia medicine is prevented and treated with chemical drugs or Chinese medicine are constituted.
5. a kind of preparation method of the pharmaceutical composition for preventing and treating climacteric metancholia, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Chinese viburnum stem 4800-4900 weight portions three-jaw gold dragon 50-80 weight portions Eurya plant wood
3500-3700 weight portion alpha, beta-lonone 40-70 weight portion euparotin 100-110 weight portion golden wave chalcone 60-
70 weight portions；
Preparation method：
（1）Three-jaw gold dragon, Eurya plant wood, Chinese viburnum stem, alpha, beta-lonone, euparotin, golden wave are taken by bulk drug proportioning look into ear
Ketone, mixes, and with the ethanol of weight percent concentration 44% as solvent, is taken in 29 DEG C of temperature extractions, and extraction time is 13 times, is carried every time
The time is taken for 53 hours, each solvent load is 68 times of bulk drug gross weight, and filtration obtains dregs of a decoction A and extract solution A, extract solution A
Ethanol is reclaimed, relative density 1.16 is concentrated into, filtered, liquid is first washed with water by XAD1600 large pore resin absorption columns, then
XAD1600 large pore resin absorption columns are eluted with the ethanol solution of weight percent concentration 37%, the second of weight percent concentration 37% is collected
Alcohol eluen, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 55% as solvent, heating and refluxing extraction 27 times is carried every time
The time is taken for 0.1 hour, each solvent load is 39 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.06 is concentrated into, filtered, liquid is first washed with water, then use by GDX-501 large pore resin absorption columns
The ethanol solution of weight percent concentration 77% elutes GDX-501 large pore resin absorption columns, collects the ethanol of weight percent concentration 77%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition for preventing and treating climacteric metancholia according to claim 5, it is characterised in that
Prepare as follows：
The composition and weight portion of bulk drug be：The weight portion three-jaw of Chinese viburnum stem 4850 gold 3600 weight portions of imperial 65 weight portion Eurya plant wood
The weight portion of 60 weight portion euparotin of alpha, beta-lonone, 105 weight portion golden wave chalcone 65；
Preparation method：
（1）Three-jaw gold dragon, Eurya plant wood, Chinese viburnum stem, alpha, beta-lonone, euparotin, golden wave are taken by bulk drug proportioning look into ear
Ketone, mixes, and with the ethanol of weight percent concentration 44% as solvent, is taken in 29 DEG C of temperature extractions, and extraction time is 13 times, is carried every time
The time is taken for 53 hours, each solvent load is 68 times of bulk drug gross weight, and filtration obtains dregs of a decoction A and extract solution A, extract solution A
Ethanol is reclaimed, relative density 1.16 is concentrated into, filtered, liquid is first washed with water by XAD1600 large pore resin absorption columns, then
XAD1600 large pore resin absorption columns are eluted with the ethanol solution of weight percent concentration 37%, the second of weight percent concentration 37% is collected
Alcohol eluen, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 55% as solvent, heating and refluxing extraction 27 times is carried every time
The time is taken for 0.1 hour, each solvent load is 39 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.06 is concentrated into, filtered, liquid is first washed with water, then use by GDX-501 large pore resin absorption columns
The ethanol solution of weight percent concentration 77% elutes GDX-501 large pore resin absorption columns, collects the ethanol of weight percent concentration 77%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition for preventing and treating climacteric metancholia according to claim 5, it is characterised in that
Pharmaceutical composition can prepare piece agent or capsule or dripping pill using the conventional method of galenic pharmacy.
8. a kind of preparation method of the pharmaceutical composition for preventing and treating climacteric metancholia according to claim 5, it is characterised in that
Pharmaceutical composition prevents and treats climacteric metancholia medicine with chemical drugs or Chinese medicine composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611132933.1A CN106728467A (en) | 2016-12-10 | 2016-12-10 | A kind of pharmaceutical composition for preventing and treating climacteric metancholia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611132933.1A CN106728467A (en) | 2016-12-10 | 2016-12-10 | A kind of pharmaceutical composition for preventing and treating climacteric metancholia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106728467A true CN106728467A (en) | 2017-05-31 |
Family
ID=58875828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611132933.1A Withdrawn CN106728467A (en) | 2016-12-10 | 2016-12-10 | A kind of pharmaceutical composition for preventing and treating climacteric metancholia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106728467A (en) |
-
2016
- 2016-12-10 CN CN201611132933.1A patent/CN106728467A/en not_active Withdrawn
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