CN106822368A - Prevent and treat pharmaceutical composition of senile vaginitis and preparation method thereof - Google Patents

Prevent and treat pharmaceutical composition of senile vaginitis and preparation method thereof Download PDF

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CN106822368A
CN106822368A CN201611132928.0A CN201611132928A CN106822368A CN 106822368 A CN106822368 A CN 106822368A CN 201611132928 A CN201611132928 A CN 201611132928A CN 106822368 A CN106822368 A CN 106822368A
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不公告发明人
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Jinan Haoyu Qingtian Medicine Technology Co ltd
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Jinan Haoyu Qingtian Medicine Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

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Abstract

The invention discloses a kind of pharmaceutical composition for preventing and treating senile vaginitis and preparation method thereof, pharmaceutical composition of the present invention is with pachydermia fragrant flower, purple cylinder grass, goumi fruit, Hydrangea xanthoncura Diels root, Chinese viburnum stem as bulk drug, proportioning is formed, routinely various formulations can be made by preparation process, preventing and treating senile vaginitis are evident in efficacy.

Description

Prevent and treat pharmaceutical composition of senile vaginitis and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of pharmaceutical composition for preventing and treating senile vaginitis and its preparation Method.
Background technology
Vaginitis is the common genital disease disease of married woman, mainly involves connective under vaginal mucosa and mucous membrane Tissue, clinic is mainly shown as that vaginal fluid increases, and with external genital swelling and itch, this disease can not such as be obtained most of patients Effectively, thoroughly treat, meeting recurrent exerbation, or even form intractable vaginitis, serious shadow is caused to the physical and mental health of women Ring.Motherland's medical science thinks that senile vahinitis surely belongs to " vaginal discharge diseases ", " pruritus vulvae " category, is the menopause because kidney qi declines, liver kidney The deficiency of Yin, punching is appointed caused by deficient, damp and hot heresy invasion.And we are it is observed that the damp and hot heresy of inherence, its empty person is also in kidney Declining for cloudy last of the ten Heavenly stems water is few, and it is the deficiency of the kidney yin to search to the bottom, damp invasion of lower energizer.Modern medicine thinks that this disease is due to ovarian function Decline, decrease in estrogen, vaginal wall atrophy, mucous membrane is thinning, and glycogen is reduced in epithelial cell, and intravaginal pH value increases, office Portion's resistance reduction, it is caused that pathogenic bacteria easily invade breeding.Modern medicine study shows that kidney tonifying class Chinese medicine has oestrogen-like hormone sample Effect.Treated using estrogen drugs more than this sick doctor trained in Western medicine, there is many worries, such as caused endometrial hyperplasia, disabled Easily recurrence afterwards, medication has taboos disease etc..And the traditional Chinese medical science treat this it is sick when, from entirety, study carefully its morbidity it is at all-liver kidney Deficiency, is preferably treated with the product of the clear profit of nourshing kidney, with up to the purpose of " healthy tendency deposits interior, and heresy can not be done ".And few side effects, late relapse rate Low, patient is easy to receive.
Pachydermia fragrant flower：This product is Theaceae Ternstroemia gymnanthera platymiscium Ternstroemia gymnanthera Ternstroemia gymnanthera（Wight et Arn.）The flower of Sprague.The 7-8 months gather, and dry.【Indication】Desinsection is antipruritic.Main mange itch.【Original shape state】It is thick Skin perfume shrub or dungarunga, 3-8m high, entirety is without hair.Bark taupe；Sprig is sturdy, cylinder, band sepia, near verticillate Or multiple bifurcated.Single leaf alternate, constant piece fasciation branch end；Petiole 5-15mm long；Blade leathery, round shape obovate long or ellipse Shape, 4-11cm long, 2.5-5cm wide, tip is suddenly sharp, tapering or blunt, and base portion is wedge-shaped or gradually narrow and downward, full edge, and middle arteries are above It sink, lateral vein is not obvious.Flower both sexes, single leave armpit or fasciation sprig top；Spend faint yellow, footpath about 1.8cm；Bennet 1-2cm long, It is curved under generally；Squamella 2, ovate triangle；Sepal 5, several circles are about 4mm, and base portion slightly joint is harbored；Petal 5, ovum Shape comb shape, 5-8mm long, base portion symphysis；Stamen is most, lines up two-wheeled；Ovary is upper, and 2-3 rooms, style 1, tubbiness, column cap 3 splits. Capsule is dry berry shape, and subsphaeroidal or ellipticity is avette, footpath 1-1.5cm, yellow.Seed is red.The month at florescence 7-8, fruiting period The 8-10 months.Record in dictionary of medicinal plant.
Purple cylinder grass：This product is Boraginaceae purple cylinder grass platymiscium purple cylinder grass Stenosolenium saxatile（Pall.） Turcz.[Anchusa saxatile Pall. ;Onosma saxatile (Pall.) Lehm.] herb and root.【Property Taste】It is bitter, pungent, it is cool.【Indication】Clearing heat and cooling blood, cough-relieving of stopping blooding.Cure mainly haematemesis, cough with lung heat.Flu, arthralgia.【Original is planted Thing form】Purple cylinder grass is long 8-25 centimetres, close by thick and stiff hair and pubescence.Root appearance atropurpureus is dark brown, the black purple of section skin zone Color, woody part yellowish white, diameter 0.5-2 millimeters.Stem is in celadon or crineous, and section off-white color is hollow, diameter 0.5-2.5 Millimeter;Leaf alternate, crushes more or crimps, herbaceous stem, celadon, and complete person is in drape over one's shoulders pin bar shaped, drape over one's shoulders needle-like bar shaped.Flower brown color. Pyrene is avette in triangular shape, normal 4 it is raw together.Gas is micro-, mildly bitter flavor.Record in dictionary of medicinal plant.
Chinese viburnum stem：It is the stem of Caprifoliaceae Viburnum plant silk ball Jia Opulus Viburnum macrocephalum Fort.. Whole year can be harvested, and segment is dried.【Nature and flavor】Bitter；It is cool in nature.【Indication】Eliminating dampness is antipruritic.Main scabies is fresh；Wet rotten pain of itching.【Medicine Reason is acted on】The V. macrocephalum that European and American countries were once produced with it in one's early years（Europe V. macrocephalum Viburnumopulus or U.S. V. macrocephalums V.prunifolium）Preparation controls irregular menstruation, uterine hemorrhage, antenatal pain etc. as uterus sedative, records in American-European one In the pharmacopeia of a little countries.V. macrocephalum contained glucoside in Europe has contraction to uterus, blood vessel；Additionally, also containing inhibition composition; 50% alcohol extracting thing effect is preferable.Fruit energy cardiac stimulant, diuresis.【Former phytomorph】Silk ball Jia Opulus fall leaves or semi-evergreen shrubs, high Up to 4m.Sprout is considered to be worth doing by dirt and closes stellate hair, old branch grey black, and hibernaculum is without scale.Leaf opposite；Petiole 10-15mm long；Blade papery； Leaf is avette, oval circular to ovate square, and 5-11cm long, 2.5-4.5cm wide, tip are blunt or slightly sharp, base portion circle or sometimes micro- heart Table, edge serration, below sparsely grow stellate hair, lateral vein 5-6 pairs, before nearly leaf margin net knot, together with above middle arteries it is slightly concave fall into, lower convexity. Cancel umbrella inflorescence diameter 8-15cm, be all made up of large-scale sterile flower；Total bennet is obvious, the 1st grade of 5 articles of radiation branch, and peanut is in the 3rd In level radiation branch；Calyx tube tubular, is about 2.5mm, and limb has 5 micro- teeth；Corolla white, spoke shape, diameter 1.5-4cm, sliver round shape Obovate, corolla tube is short；Stamen 5, is about 3mm；Gynoecium infertility.The month at florescence 4-5.Record in dictionary of medicinal plant.
Goumi fruit：It is Elaeangnaceae oleaster goumi Elaeagnus multiflora Thunb.'s Fruit.6-7 month picking fruits, dry.【Nature and flavor】It is light；It is puckery；Temperature.【Indication】Relieving asthma；Stop dysentery；Activating blood circulation and reducing swelling；Hemostasis.Main heavy breathing Breathe heavily；Dysentery；Traumatic injury；Rheumatic arthritis；Blood under hemorrhoid；Pyogenic infections.【Chemical analysis】Ripening fruits contains pigment：Tomato hydrocarbon (lycopene), and containing more sugar.The fatty oil of seed.Flower contains volatile oil.【Former phytomorph】Goumi machaka, Up to 3m.It is generally stingless, have thorn in dilute old branch；Sprout often has dark brown scale, and old branch scale comes off, and dark brown is glossy.It is single Leaf alternate, petiole rust, 4-6mm long；Leaf film quality or papery, it is oval or avette to ovate Long Circle, 3-7cm long, 1.2- wide 4cm, full edge, tip blunt point or sharp point, base portion wealthy wedge shape or circle, above children when have stellate hair and silvery scales, after gradually come off, Canescence below, close by silvery white and scattered a small number of brown scales, floral white, Chang Dan is born in the axil of shoot base portion；Perianth tube Tubulose, 5-6.5mm long, top 4 is split, sliver width egg shape, inner side sparsely grow pubescence；Stamen 4, is born in perianth tube throat slightly below, Filigree is extremely short, and flower pesticide is tiny；Style is upright, without hair, slightly stretches out perianth tube throat, long to be no more than stamen.Fruit ellipse, it is long 12-14mm, it is close by rust scale, it is red when ripe；Carpopodium extends after spending, 1.5-4cm long.The month at florescence 4-5, the fruiting period 6-7 months. Record in dictionary of medicinal plant.
Hydrangea xanthoncura Diels root：This product is Saxifragaceae silk ball platymiscium Huang arteries and veins silk ball Hydrangea xanthoneura The root of Diels.【Nature and flavor】It is pungent, temperature.【Indication】Promoting blood circulation, reunion of bone.Cure mainly fracture, rheumatic lumbago.【Proterties】 Root cylinder, distortion is about 8cm or longer, diameter about 2mm.Surface taupe, there is vertical wrinkle and radicula or root trace.Crust is easy Come off, the place that comes off is aobvious faint yellow.Matter is tough, and difficulty fractures, section yellow-white, fibroid.Gas is micro-, taste is pungent.Record in dictionary of medicinal plant.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of drug regimen of effective preventing and treating senile vaginitis Thing and preparation method thereof.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for being made the bulk drug of the pharmaceutical composition of the preventing and treating senile vaginitis be：
Pachydermia fragrant flower 220-226 weight portions purple cylinder grass 230-238 weight portion goumi fruit 210-214 weight portions hang bitter embroidery Napiform root 130-134 weight portion Chinese viburnum stem 110-112 weight portions.
The pharmaceutical composition of preventing and treating senile vaginitis is preferably used in, is made up of the bulk drug of following weight portion：
The weight portion of 212 weight portion Hydrangea xanthoncura Diels root of the weight portion of pachydermia fragrant flower 223 purple cylinder 234 weight portion goumi fruit of grass 132 The weight portion of Chinese viburnum stem 111.
A kind of pharmaceutical composition for preventing and treating senile vaginitis, it is characterised in that pharmaceutical composition can be using the normal of galenic pharmacy Rule method prepares piece agent or capsule or dripping pill.
A kind of pharmaceutical composition for preventing and treating senile vaginitis, it is characterised in that pharmaceutical composition is constituted with chemical drugs or Chinese medicine Preventing and treating senile vaginitis medicine.
A kind of preparation method of the pharmaceutical composition for preventing and treating senile vaginitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Pachydermia fragrant flower 220-226 weight portions purple cylinder grass 230-238 weight portions goumi is really Real 210-214 weight portions Hydrangea xanthoncura Diels root 130-134 weight portion Chinese viburnum stem 110-112 weight portions；
Preparation method：
（1）Pachydermia fragrant flower, purple cylinder grass, goumi fruit, Hydrangea xanthoncura Diels root, Chinese viburnum stem are taken by bulk drug proportioning, is mixed, with weight The amount ethanol of percent concentration 30.5% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 11 times, and each extraction time is 52 Hour, each solvent load is 45 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, Relative density 1.08 is concentrated into, is filtered, liquid is first washed with water, then use percentage by weight by D900 large pore resin absorption columns The ethanol solution of concentration 14% elutes D900 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 14%, reclaims second Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 64% as solvent, heating and refluxing extraction 13 times is carried every time The time is taken for 0.7 hour, each solvent load is 86 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water, then use by HC-ADS-3 large pore resin absorption columns The ethanol solution of weight percent concentration 89% elutes HC-ADS-3 large pore resin absorption columns, collects the ethanol of weight percent concentration 89% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
The preparation method of preferred a kind of pharmaceutical composition for preventing and treating senile vaginitis, it is characterised in that make as follows It is standby：
The composition and weight portion of bulk drug be：The weight portion of the pachydermia fragrant flower 223 purple cylinder grass weight of 234 weight portion goumi fruit 212 The weight portion of 132 weight portion Chinese viburnum stem of amount part Hydrangea xanthoncura Diels root 111；
Preparation method：
（1）Pachydermia fragrant flower, purple cylinder grass, goumi fruit, Hydrangea xanthoncura Diels root, Chinese viburnum stem are taken by bulk drug proportioning, is mixed, with weight The amount ethanol of percent concentration 30.5% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 11 times, and each extraction time is 52 Hour, each solvent load is 45 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, Relative density 1.08 is concentrated into, is filtered, liquid is first washed with water, then use percentage by weight by D900 large pore resin absorption columns The ethanol solution of concentration 14% elutes D900 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 14%, reclaims second Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 64% as solvent, heating and refluxing extraction 13 times is carried every time The time is taken for 0.7 hour, each solvent load is 86 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water, then use by HC-ADS-3 large pore resin absorption columns The ethanol solution of weight percent concentration 89% elutes HC-ADS-3 large pore resin absorption columns, collects the ethanol of weight percent concentration 89% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for preventing and treating senile vaginitis, it is characterised in that pharmaceutical composition can be used The conventional method of galenic pharmacy prepares piece agent or capsule or dripping pill.
A kind of preparation method of the pharmaceutical composition for preventing and treating senile vaginitis, it is characterised in that pharmaceutical composition and chemical drugs Or Chinese medicine composition preventing and treating senile vaginitis medicine.
Pharmaceutical composition preventing and treating senile vaginitis are evident in efficacy.
Specific embodiment
Embodiment 1：Prevent and treat pharmaceutical composition of senile vaginitis and preparation method thereof
Prevent and treat senile vaginitis pharmaceutical composition bulk drug composition and weight portion be：Pachydermia fragrant flower 223g purple cylinder grass 234g goumi fruit 212g Hydrangea xanthoncura Diels root 132g Chinese viburnum stems 111g；
Preparation method：
（1）Pachydermia fragrant flower, purple cylinder grass, goumi fruit, Hydrangea xanthoncura Diels root, Chinese viburnum stem are taken by bulk drug proportioning, is mixed, with weight The amount ethanol of percent concentration 30.5% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 11 times, and each extraction time is 52 Hour, each solvent load is 45 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, Relative density 1.08 is concentrated into, is filtered, liquid is first washed with water, then use percentage by weight by D900 large pore resin absorption columns The ethanol solution of concentration 14% elutes D900 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 14%, reclaims second Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 64% as solvent, heating and refluxing extraction 13 times is carried every time The time is taken for 0.7 hour, each solvent load is 86 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water, then use by HC-ADS-3 large pore resin absorption columns The ethanol solution of weight percent concentration 89% elutes HC-ADS-3 large pore resin absorption columns, collects the ethanol of weight percent concentration 89% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Prevent and treat pharmaceutical composition of senile vaginitis and preparation method thereof
Prevent and treat senile vaginitis pharmaceutical composition bulk drug composition and weight portion be：Pachydermia fragrant flower 220g purple cylinder grass 238g goumi fruit 210g Hydrangea xanthoncura Diels root 134g Chinese viburnum stems 110g；
Preparation method：
（1）Pachydermia fragrant flower, purple cylinder grass, goumi fruit, Hydrangea xanthoncura Diels root, Chinese viburnum stem are taken by bulk drug proportioning, is mixed, with weight The amount ethanol of percent concentration 30.5% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 11 times, and each extraction time is 52 Hour, each solvent load is 45 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, Relative density 1.08 is concentrated into, is filtered, liquid is first washed with water, then use percentage by weight by D900 large pore resin absorption columns The ethanol solution of concentration 14% elutes D900 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 14%, reclaims second Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 64% as solvent, heating and refluxing extraction 13 times is carried every time The time is taken for 0.7 hour, each solvent load is 86 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water, then use by HC-ADS-3 large pore resin absorption columns The ethanol solution of weight percent concentration 89% elutes HC-ADS-3 large pore resin absorption columns, collects the ethanol of weight percent concentration 89% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Prevent and treat pharmaceutical composition of senile vaginitis and preparation method thereof
Prevent and treat senile vaginitis pharmaceutical composition bulk drug composition and weight portion be：Pachydermia fragrant flower 226g purple cylinder grass 230g goumi fruit 214g Hydrangea xanthoncura Diels root 130g Chinese viburnum stems 112g；
Preparation method：
（1）Pachydermia fragrant flower, purple cylinder grass, goumi fruit, Hydrangea xanthoncura Diels root, Chinese viburnum stem are taken by bulk drug proportioning, is mixed, with weight The amount ethanol of percent concentration 30.5% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 11 times, and each extraction time is 52 Hour, each solvent load is 45 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, Relative density 1.08 is concentrated into, is filtered, liquid is first washed with water, then use percentage by weight by D900 large pore resin absorption columns The ethanol solution of concentration 14% elutes D900 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 14%, reclaims second Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 64% as solvent, heating and refluxing extraction 13 times is carried every time The time is taken for 0.7 hour, each solvent load is 86 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water, then use by HC-ADS-3 large pore resin absorption columns The ethanol solution of weight percent concentration 89% elutes HC-ADS-3 large pore resin absorption columns, collects the ethanol of weight percent concentration 89% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
The pharmaceutical composition 520g of Example 1, adds starch 630g, mixes, and granulation is dried, plus microcrystalline cellulose 310g, stearic Sour magnesium 20g, mixes, and is pressed into 6500, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
The pharmaceutical composition 1530g of Example 2, adds starch 2370g, mixes, and granulation is dried, whole grain, adds appropriate stearic acid Magnesium, mixes, and encapsulated 9000, obtains final product medicament composition capsule.
Embodiment 6：The preparation of dripping pill
Weigh (80 DEG C) heating of Macrogol 6000 140g water-baths and boil molten, add the pharmaceutical composition 10g of embodiment 3, fully stir Mix uniform, with atoleine as cooling agent, put glass tube（4*80cm）In, chilling temperature is 5 DEG C, and drip internal-and external diameter is 7.0/ 2.0 (mm/mm), drip is 2.4cm away from liquid level, and drop speed is optimum condition with every point 58 drop, and the cold of dripping pill surface is blotted with cotton Solidifying agent, obtains final product medicament composition dropping pills.
Embodiment 7：Prevent and treat the pharmaceutical composition of senile vaginitis
Prevent and treat senile vaginitis pharmaceutical composition bulk drug composition and weight portion be：
The weight portion of 100 weight portion Hydrangea xanthoncura Diels root of goumi fruit 280 purple cylinder 190 weight portions of grass.
Embodiment 8：Prevent and treat the pharmaceutical composition of senile vaginitis
Prevent and treat senile vaginitis pharmaceutical composition bulk drug composition and weight portion be：
The weight portion of 120 250 weight portion Chinese viburnum stem of weight portion Hydrangea xanthoncura Diels root of goumi fruit 160.
Embodiment 9：Prevent and treat the pharmaceutical composition of senile vaginitis
Prevent and treat senile vaginitis pharmaceutical composition bulk drug composition and weight portion be：
The weight portion of 150 240 weight portion Chinese viburnum stem of weight portion Hydrangea xanthoncura Diels root of goumi fruit 170.
Experimental example 1：Prevent and treat the experimental study of senile vaginitis
1. clinical data
Observation case 46, is 2012~2013 years out-patients of this city hospital, 36~63 years old age, average 52 years old.46 Patient meets this sick Western medicine diagnostic criteria and Standards of Chinese Medical Syndrome Differentiation, and row ultrasound diagnosis endometrium is equal<5mm.By 46 diseases People is randomly divided into two groups, i.e. treatment group 23, and control group 23 is statistically analyzed, and two groups in sex, age, course of disease distribution On without significant difference, with comparativity.
2. treatment method
Treatment group uses pharmaceutical composition（The pharmaceutical composition of embodiment 1）Orally, with reference to Chinese herbal fumigation and washing.Orally:Drug regimen Thing, each 0.7g, 3 times a day.External application:Pharmaceutical composition 4g, adds 1000mL dissolved in boiled water, fumigates vulva, treats fluid temperature Moderate rear 10~15min of hip bath.14d is 1 course for the treatment of.
Beimeili ointment (production of U.S. Hui Shi-Li Da Suzhou pharmaceutical Co. Ltd) 1g is applied to the moon by this group of control group Road, one time a day, and 14d is 1 course for the treatment of.
3. criterion of therapeutical effect
Reference《Chinese medical disease Standardization of diagnosis and curative effect》And《New Chinese medicine treats the guideline of clinical investigations of senile vahinitis》 Formulate.
Recovery from illness:Clinical symptoms, sign are wholly absent, and vagina mucosa is congested to disappear, and I degree of vagina cleanness degree, follow-up March is not multiple Hair.
It is effective:Clinical symptoms, sign disappear substantially, and vagina mucosa hyperemia is clearly better, I~II degree of vagina cleanness degree.
Effectively:Clinical symptoms, sign take a turn for the better, II degree of vagina cleanness degree.
It is invalid:Clinical symptoms, sign are unchanged, and vagina cleanness degree is unchanged.
Tcm syndrome curative effect determinate standard (tcm syndrome curative effect is judged according to integration method) computing formula:[(treatment foreset Integrated after dividing-treating)/treat preceding integration] × 100%.Recovery from illness:Syndrome integral reduces >=90%；It is effective:90%>Syndrome integral is reduced ≥70%；Effectively:70%>Syndrome integral reduces >=30%；It is invalid:Syndrome integral is reduced<30%.
4. treatment results
Two groups of clinical efficacies the results are shown in Table 1.
1 two groups of clinical efficacies of table
Group n Recovery from illness It is effective Effectively It is invalid Cure rate (%)
Treatment group 23 21 1 1 0 91.30
Control group 23 12 6 5 0 52.17
Note:Cure rate treatment group is better than control group, P<0.05.
Two groups of tcm syndrome curative effects are shown in Table 2.
2 two groups of tcm syndrome curative effect tables of table
Group n Recovery from illness It is effective Effectively It is invalid Cure rate Total effective rate
Treatment group 23 22 1 0 0 95.65% 100%
Control group 23 12 6 5 0 52.17% 100%
Note:Cure rate treatment group is significantly better than control group, P<0.01.

Claims (8)

1. it is a kind of prevent and treat senile vaginitis pharmaceutical composition, it is characterised in that be made the composition of the bulk drug of the pharmaceutical composition It is with weight portion：
Pachydermia fragrant flower 220-226 weight portions purple cylinder grass 230-238 weight portion goumi fruit 210-214 weight portions hang bitter embroidery Napiform root 130-134 weight portion Chinese viburnum stem 110-112 weight portions.
2. according to claim 1 it is a kind of prevent and treat senile vaginitis pharmaceutical composition, it is characterised in that be made the medicine group The composition and weight portion of the bulk drug of compound be：
The weight portion of 212 weight portion Hydrangea xanthoncura Diels root of the weight portion of pachydermia fragrant flower 223 purple cylinder 234 weight portion goumi fruit of grass 132 The weight portion of Chinese viburnum stem 111.
3. according to claim 1 it is a kind of prevent and treat senile vaginitis pharmaceutical composition, it is characterised in that pharmaceutical composition can Piece agent or capsule or dripping pill are prepared with using the conventional method of galenic pharmacy.
4. according to claim 1 it is a kind of prevent and treat senile vaginitis pharmaceutical composition, it is characterised in that pharmaceutical composition with The preventing and treating senile vaginitis medicine of chemical drugs or Chinese medicine composition.
5. it is a kind of prevent and treat senile vaginitis pharmaceutical composition preparation method, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Pachydermia fragrant flower 220-226 weight portions purple cylinder grass 230-238 weight portions goumi is really Real 210-214 weight portions Hydrangea xanthoncura Diels root 130-134 weight portion Chinese viburnum stem 110-112 weight portions；
Preparation method：
（1）Pachydermia fragrant flower, purple cylinder grass, goumi fruit, Hydrangea xanthoncura Diels root, Chinese viburnum stem are taken by bulk drug proportioning, is mixed, with weight The amount ethanol of percent concentration 30.5% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 11 times, and each extraction time is 52 Hour, each solvent load is 45 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, Relative density 1.08 is concentrated into, is filtered, liquid is first washed with water, then use percentage by weight by D900 large pore resin absorption columns The ethanol solution of concentration 14% elutes D900 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 14%, reclaims second Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 64% as solvent, heating and refluxing extraction 13 times is carried every time The time is taken for 0.7 hour, each solvent load is 86 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water, then use by HC-ADS-3 large pore resin absorption columns The ethanol solution of weight percent concentration 89% elutes HC-ADS-3 large pore resin absorption columns, collects the ethanol of weight percent concentration 89% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. according to claim 5 it is a kind of prevent and treat senile vaginitis pharmaceutical composition preparation method, it is characterised in that press It is prepared by following steps：
The composition and weight portion of bulk drug be：The weight portion of the pachydermia fragrant flower 223 purple cylinder grass weight of 234 weight portion goumi fruit 212 The weight portion of 132 weight portion Chinese viburnum stem of amount part Hydrangea xanthoncura Diels root 111；
Preparation method：
（1）Pachydermia fragrant flower, purple cylinder grass, goumi fruit, Hydrangea xanthoncura Diels root, Chinese viburnum stem are taken by bulk drug proportioning, is mixed, with weight The amount ethanol of percent concentration 30.5% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 11 times, and each extraction time is 52 Hour, each solvent load is 45 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, Relative density 1.08 is concentrated into, is filtered, liquid is first washed with water, then use percentage by weight by D900 large pore resin absorption columns The ethanol solution of concentration 14% elutes D900 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 14%, reclaims second Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 64% as solvent, heating and refluxing extraction 13 times is carried every time The time is taken for 0.7 hour, each solvent load is 86 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water, then use by HC-ADS-3 large pore resin absorption columns The ethanol solution of weight percent concentration 89% elutes HC-ADS-3 large pore resin absorption columns, collects the ethanol of weight percent concentration 89% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. according to claim 5 it is a kind of prevent and treat senile vaginitis pharmaceutical composition preparation method, it is characterised in that medicine Compositions can prepare piece agent or capsule or dripping pill using the conventional method of galenic pharmacy.
8. according to claim 5 it is a kind of prevent and treat senile vaginitis pharmaceutical composition preparation method, it is characterised in that medicine Compositions and chemical drugs or Chinese medicine composition preventing and treating senile vaginitis medicine.
CN201611132928.0A 2016-12-10 2016-12-10 Prevent and treat pharmaceutical composition of senile vaginitis and preparation method thereof Withdrawn CN106822368A (en)

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