CN106581357A - Pharmaceutical composition for treatment of recurrent oral ulcer - Google Patents
Pharmaceutical composition for treatment of recurrent oral ulcer Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for treatment of recurrent oral ulcer and a preparing method thereof. The pharmaceutical composition is prepared by proportioning fimbristylis dichotoma, all-grass of auriculate dichrocephala, asarinin, homoplantaginin and peonidin as raw material medicines, can be made into various dosage forms according to a conventional preparation process, and has remarkable curative effect on treatment of recurrent oral ulcer.
Description
Technical field
The invention belongs to technical field of Chinese medicines, more particularly to a kind of pharmaceutical composition for treating recurrent oral ulceration and its
Preparation method.
Background technology
The cause of disease of recurrent oral ulceration is still not clear at present, though thus Therapeutic Method is more, curative effect is undesirable.It is clinical
On can extend the intermission with reference to whole body therapeutic through local treatment, shorten stage of attack, alleviate disease relapse oral ulcer local
Treatment with antiinflammatory, pain relieving, promote healing as main principle, recurrent oral ulceration whole body therapeutic with etiological treatment, reduce recurrence,
Healing is promoted to be main principle, the traditional Chinese medical science, with reference to negative and positive the exterior and the interior, is trembled with fear according to the clinical manifestation of all kinds of diseases of recurrent oral ulceration
Hot deficiency and excess and the vital organs of the human body carry out dialectical and classification, it is believed that pathogenic factor can be divided into two aspects of deficiency and excess.With the deficiency of YIN in asthenic fire type
Fire type for most common, more based on deficiency of the kidney yin, the also type such as visible deficiency of heart-yin, hepatic and renal YIN deficiency, the deficient then dizziness and tinnitus of kidney yin,
Night sweat, seminal emission, soreness of the waist and knees, hectic fever in the afternoon；Disarmony between the heart and kidney then vexed cardiopalmus, insomnia forgetfulness, feverish sensation in the palms and soles, soreness of waist seminal emission；Liver
Kidney deficiency is damaged then wantonly two arteries and veins of punching and is not filled, and causes menoxenia；Then ulcer complexion is not light red for the deficiency of YIN, and edema oozes out less, red lip xerostomia
Desire for cold drinks, dry stool yellowish urine, red tongue with thin and yellow fur, deep pulse is counted accurately or stringy and thready pulse number etc. be hyperactivity of fire caused by deficiency of YIN as.YIN nourishing has with heat clearing away
Certain antimicrobial antiphlogistic effect, can strengthen the phagocytic activity of macrophage, and YIN nourishing is shared with heat clearing away, and its effect again can be better than independent
YIN nourishing or heat clearing away, therefore, nourishing YIN and clearing away heat not only directly acts on pathogenic factor place, eliminates cause of disease relief of symptoms, and can strengthen
Body disease-resistant and repair ability, are to attack benefit to combine, an effective method for the treatment of both the principal and secondary aspects of a disease.
Herba Fimbristylis dichotomae：For qi Herba Fimbristylis dichotomae Fimbristylis dichotoma (L) Vahl of Cyperaceae genus fimbristylis plant two
[Scirpus dichotomus L.;S.annuus All.;Fimbristylis annua(All.)Roem.et Schult]
Herb.Summer, autumn harvesting, clean, and dry.【Nature and flavor】It is lightly seasoned；It is cold in nature.【Return through】Kidney；Bladder warp.【Indication】Heat clearing away profit
Urine；Removing toxic substances.Main dysuria；Damp and hot edema；Gonorrhea；Infantile carbuncle.【Chemical analysis】Containing dihydrocyperaquinone
(dihydrooyperaqnone), tetrahydrocyperaquinone.(tetrahydrocyperaquinone), cyperaquinone
(cyperapuinone), hydroxyl cyperaquinone (hydroxycyperapuinone), nor- cyperaquinone
(demethylcyperapuinone).【Former phytomorph】Not tally Herba Fimbristylis dichotomae, draft.Stalk is grown thickly, high 20-50cm.Herb without
Hair has thin pubescence.Leaf is linear, is shorter than stalk, and wide 1-2.5mm, tip is suddenly sharp or blunt；Sheath base portion keratin.Lobate bract under inflorescence
3-4, normal 1-2 pieces, is longer than inflorescence.Cyme is appeared again or simply；Small ear is avette or long round shape is avette, long 5-12mm, wide 2-
3mm, there is most flowers；Scale is avette or Long Circle, long 2-2.5mm, and sepia is glossy, there is 3-5 arteries and veins, and tip has short point；Stamen
2-3；Style is flat, and echinid is arranged at top；Stigma 2.Pyrene width obovate, biconvex shape, long 1-1.2mm, white to filbert,
Surface is grown crosswise circular reticulate pattern, and longitudinal rib 7-9 bar, significant protuberance has brown short handle.Flower, the fruiting period 7-10 month.Record diction big in Chinese medicine
Allusion quotation.
Herba Dichrocephalae auriculatae：This product is Compositae Dichrocephala plant Herba Houttuyniae Dichrocephala auriculata (Thunb.)
The herb of Druce [Ethulia auriculata Thunb.].Summer, autumn harvesting, dry.【Nature and flavor】Bitter in the mouth；It is pungent；It is mild-natured.
【Indication】Promoting blood flow to regulate menstruation；Removing toxic substances and promoting subsidence of swelling.Main menoxenia；Sprain and swell and ache；Furunculosis；Venom.【Former phytomorph】Fish
The careless annual herb of eye, high 15-50cm.Stem is upright or paving dissipates, without hair or by pubescence.Blade is avette, oval or drapes over one's shoulders pin
Shape, long 3-10cm, major part plumage split, Capping piece is roomy, wide up to 4cm, and side sliver is normal 1 pair, dilute 2 pairs, and two sides is without hair or by sparse short
Pubescence.Head inflorescence is minimum, spherical, diameter about 5mm, is born in dichotomy top, and most head inflorescences are on stem top or branch top
Line up loose umbrella room shape in end；Stalk is up to 3cm；Phyllary 1-2 layers；Holder semicircle spherical protuberances, above hold level with both hands；Disc floret both sexes；Energy
Educate；Corolla tip has 4-5 teeth.Achene is flat, the edge for having thickening；Without pappus.At the beginning of late summer at florescence to the winter.Record diction big in Chinese medicine
Allusion quotation.
Homoplantaginin（Homoplantaginin）：CAS 17680-84-1, molecular formula C22H22O11, molecular weight
462.40.【Pharmacological action】Tracheitiies are controlled, antitussive, eliminating the phlegm is relievingd asthma, antitussive, eliminating the phlegm.【Ingredient origin】Labiate Herba Salviae Plebeiae
Herb.
Peonidin (Peonidin):CAS 26838-13-1, molecular formula C22H23ClO11, molecular weight 498.87.
【Pharmacological action】Antiinflammatory.【Ingredient origin】Ericaceae Andromeda berry, yak Er Miao section's Pelargoniums and Paeoniaceae Radix Paeoniae
During category is spent.
Asarinin（Asarinin ）：CAS 133-05-1, molecular formula C20H18O6, molecular weight 354.35.【Pharmacology is made
With】Sensitization is have to Pyrethrum.【Ingredient origin】Arnold jacquard weave green pepper Zanthaxylum arnottianum, get Ka Rui spend
Green pepper Zanthoxylum decatyi, Fructus Piperiss Pericarpium Zanthoxyli Zanthoxylum piperitum, royal paulownia Paulownia
Tomentosa, Herba Asari A.sarum .sieboldii.
3 crude drug chemical constitutions：
Peonidin (Peonidin)
Homoplantaginin（Homoplantaginin）Asarinin（Asarinin ）.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of medicine of effectively treatment recurrent oral ulceration
Compositionss and preparation method thereof.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for making the crude drug of the pharmaceutical composition of the treatment recurrent oral ulceration be：
Herba Fimbristylis dichotomae 481-487 weight portion Herba Dichrocephalae auriculatae 264-268 weight portion asarinin 42-48 weight portion Homoplantaginin 34-36
Weight portion peonidin 8-10 weight portions.
The pharmaceutical composition for the treatment of recurrent oral ulceration is preferably used in, is made up of the crude drug of following weight portion：
The weight portion flower of Paeonia lactiflora Pal1. of 45 weight portion Homoplantaginin of Herba Fimbristylis dichotomae 484 weight portion Herba Dichrocephalae auriculatae, 266 weight portion asarinin 35
Blue or green plain 9 weight portion.
A kind of pharmaceutical composition for treating recurrent oral ulceration, it is characterised in that pharmaceutical composition can adopt galenic pharmacy
Conventional method prepare piece agent or capsule or drop pill.
A kind of pharmaceutical composition for treating recurrent oral ulceration, it is characterised in that pharmaceutical composition and chemical drugs or Chinese medicine
The treatment recurrent oral ulceration medicine of composition.
A kind of preparation method of the pharmaceutical composition for treating recurrent oral ulceration, it is characterised in that make as follows
It is standby：
The composition and weight portion of crude drug is Herba Fimbristylis dichotomae 481-487 weight portion Herba Dichrocephalae auriculatae 264-268 weight portion asarinin 42-
48 weight portion Homoplantaginin 34-36 weight portion peonidin 8-10 weight portions；
Preparation method：
（1）Herba Fimbristylis dichotomae, Herba Dichrocephalae auriculatae, asarinin, Homoplantaginin, peonidin are taken by crude drug proportioning, is mixed, with weight hundred
Divide the ethanol of specific concentration 52% as solvent, 34 DEG C of warm macerating are extracted, extraction time is 8 times, each extraction time is 7 hours, molten every time
Agent consumption is 17 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into relatively close
Degree 1.11, filtration, medicinal liquid is first washed with water by HPD750 macroporous adsorptive resins, then with the ethanol of weight percent concentration 44%
Eluant solution HPD750 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 44%, reclaim ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 64% as solvent, heating and refluxing extraction 6 times, carries every time
The time is taken for 0.6 hour, each solvent load is 14 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned
Ethanol is received, relative density 1.16 is concentrated into, is filtered, medicinal liquid is first washed with water by LK07 macroporous adsorptive resins, then uses weight
The ethanol solution eluting LK07 macroporous adsorptive resins of percent concentration 56%, collect the ethanol elution of weight percent concentration 56%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition for treating recurrent oral ulceration, it is characterised in that by following step
It is rapid to prepare：
The composition and weight portion of crude drug be：The weight portion of 484 weight portion Herba Dichrocephalae auriculatae of Herba Fimbristylis dichotomae, 266 weight portion asarinin 45
The weight portion of 35 weight portion peonidin of Homoplantaginin 9；
Preparation method：
（1）Herba Fimbristylis dichotomae, Herba Dichrocephalae auriculatae, asarinin, Homoplantaginin, peonidin are taken by crude drug proportioning, is mixed, with weight hundred
Divide the ethanol of specific concentration 52% as solvent, 34 DEG C of warm macerating are extracted, extraction time is 8 times, each extraction time is 7 hours, molten every time
Agent consumption is 17 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into relatively close
Degree 1.11, filtration, medicinal liquid is first washed with water by HPD750 macroporous adsorptive resins, then with the ethanol of weight percent concentration 44%
Eluant solution HPD750 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 44%, reclaim ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 64% as solvent, heating and refluxing extraction 6 times, carries every time
The time is taken for 0.6 hour, each solvent load is 14 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned
Ethanol is received, relative density 1.16 is concentrated into, is filtered, medicinal liquid is first washed with water by LK07 macroporous adsorptive resins, then uses weight
The ethanol solution eluting LK07 macroporous adsorptive resins of percent concentration 56%, collect the ethanol elution of weight percent concentration 56%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for treating recurrent oral ulceration, it is characterised in that pharmaceutical composition can be with
Piece agent or capsule or drop pill are prepared using the conventional method of galenic pharmacy.
A kind of preparation method of the pharmaceutical composition for treating recurrent oral ulceration, it is characterised in that pharmaceutical composition and change
Learn medicine or Chinese medicine composition treatment recurrent oral ulceration medicine.
Medicine composite for curing recurrent oral ulceration is evident in efficacy.
Specific embodiment
Embodiment 1：Pharmaceutical composition for the treatment of recurrent oral ulceration and preparation method thereof
Treatment recurrent oral ulceration pharmaceutical composition crude drug composition and weight portion be：Herba Fimbristylis dichotomae 484g Herba Dichrocephalae auriculataes
266g asarinin 45g Homoplantaginin 35g peonidin 9g；
Preparation method：
（1）Herba Fimbristylis dichotomae, Herba Dichrocephalae auriculatae, asarinin, Homoplantaginin, peonidin are taken by crude drug proportioning, is mixed, with weight hundred
Divide the ethanol of specific concentration 52% as solvent, 34 DEG C of warm macerating are extracted, extraction time is 8 times, each extraction time is 7 hours, molten every time
Agent consumption is 17 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into relatively close
Degree 1.11, filtration, medicinal liquid is first washed with water by HPD750 macroporous adsorptive resins, then with the ethanol of weight percent concentration 44%
Eluant solution HPD750 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 44%, reclaim ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 64% as solvent, heating and refluxing extraction 6 times, carries every time
The time is taken for 0.6 hour, each solvent load is 14 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned
Ethanol is received, relative density 1.16 is concentrated into, is filtered, medicinal liquid is first washed with water by LK07 macroporous adsorptive resins, then uses weight
The ethanol solution eluting LK07 macroporous adsorptive resins of percent concentration 56%, collect the ethanol elution of weight percent concentration 56%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Pharmaceutical composition for the treatment of recurrent oral ulceration and preparation method thereof
Treatment recurrent oral ulceration pharmaceutical composition crude drug composition and weight portion be：Herba Fimbristylis dichotomae 481g Herba Dichrocephalae auriculataes
268g asarinin 42g Homoplantaginin 36g peonidin 8g；
Preparation method：
（1）Herba Fimbristylis dichotomae, Herba Dichrocephalae auriculatae, asarinin, Homoplantaginin, peonidin are taken by crude drug proportioning, is mixed, with weight hundred
Divide the ethanol of specific concentration 52% as solvent, 34 DEG C of warm macerating are extracted, extraction time is 8 times, each extraction time is 7 hours, molten every time
Agent consumption is 17 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into relatively close
Degree 1.11, filtration, medicinal liquid is first washed with water by HPD750 macroporous adsorptive resins, then with the ethanol of weight percent concentration 44%
Eluant solution HPD750 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 44%, reclaim ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 64% as solvent, heating and refluxing extraction 6 times, carries every time
The time is taken for 0.6 hour, each solvent load is 14 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned
Ethanol is received, relative density 1.16 is concentrated into, is filtered, medicinal liquid is first washed with water by LK07 macroporous adsorptive resins, then uses weight
The ethanol solution eluting LK07 macroporous adsorptive resins of percent concentration 56%, collect the ethanol elution of weight percent concentration 56%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Pharmaceutical composition for the treatment of recurrent oral ulceration and preparation method thereof
Treatment recurrent oral ulceration pharmaceutical composition crude drug composition and weight portion be：Herba Fimbristylis dichotomae 487g Herba Dichrocephalae auriculataes
264g asarinin 48g Homoplantaginin 34g peonidin 10g；
Preparation method：
（1）Herba Fimbristylis dichotomae, Herba Dichrocephalae auriculatae, asarinin, Homoplantaginin, peonidin are taken by crude drug proportioning, is mixed, with weight hundred
Divide the ethanol of specific concentration 52% as solvent, 34 DEG C of warm macerating are extracted, extraction time is 8 times, each extraction time is 7 hours, molten every time
Agent consumption is 17 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into relatively close
Degree 1.11, filtration, medicinal liquid is first washed with water by HPD750 macroporous adsorptive resins, then with the ethanol of weight percent concentration 44%
Eluant solution HPD750 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 44%, reclaim ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 64% as solvent, heating and refluxing extraction 6 times, carries every time
The time is taken for 0.6 hour, each solvent load is 14 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned
Ethanol is received, relative density 1.16 is concentrated into, is filtered, medicinal liquid is first washed with water by LK07 macroporous adsorptive resins, then uses weight
The ethanol solution eluting LK07 macroporous adsorptive resins of percent concentration 56%, collect the ethanol elution of weight percent concentration 56%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
The pharmaceutical composition 525g of Example 1, adds starch 455g, mixes, and granulation is dried, plus Microcrystalline Cellulose 150g, Hard Fat
Sour magnesium 10g, mixes, and is pressed into 4000, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
The pharmaceutical composition 360g of Example 2, adds starch 490g, mixes, and granulation is dried, granulate, adds appropriate stearic acid
Magnesium, mixes, and encapsulated 2000, obtains final product medicament composition capsule.
Embodiment 6：The preparation of drop pill
Weigh (80 DEG C) heating of polyethylene glycol 6000 215g water-baths and boil molten, add the g of 3 pharmaceutical composition of embodiment 11, fully stir
Mix uniform, with liquid paraffin as coolant, put glass tubing（4*80cm）In, chilling temperature is -6 DEG C, and drip internal-and external diameter is 7.0/
2.0 (mm/mm), drip is 2.5cm away from liquid level, and drop speed, as optimum condition, with cotton the cold of drop pill surface is blotted with per point 51 drops
Solidifying agent, obtains final product medicament composition dropping pills.
Embodiment 7：The pharmaceutical composition for the treatment of recurrent oral ulceration
Treatment recurrent oral ulceration pharmaceutical composition crude drug composition and weight portion be：
The weight portion of 130 weight portion Homoplantaginin of asarinin, 2 weight portion peonidin 40.
Embodiment 8：The pharmaceutical composition for the treatment of recurrent oral ulceration
Treatment recurrent oral ulceration pharmaceutical composition crude drug composition and weight portion be：
The weight portion of 20 weight portion Homoplantaginin of asarinin, 120 weight portion peonidin 2.
Embodiment 9：The pharmaceutical composition for the treatment of recurrent oral ulceration
Treatment recurrent oral ulceration pharmaceutical composition crude drug composition and weight portion be：
The weight portion of 30 weight portion Homoplantaginin of asarinin, 120 weight portion peonidin 3.
Experimental example 1：The experimental study for the treatment of recurrent oral ulceration
1 clinical data
1.1 physical data
The type of hyperactivity of fire caused by deficiency of YIN recurrent oral ulceration case 40 for selecting to be gone to a doctor in city's hospital outpatient by differential diagnosis in tcm, its
Middle male 20, female 20, age 16-70 year.
1.2 prescription
1.2.1 replenishing YIN and removing heat soup prescription is constituted
Pharmaceutical composition：The pharmaceutical composition lot number 20091124 of embodiment 1.
1.2.2 Chinese medical collutory main component Herba Asari, Radix Scrophulariae, pharmaceutical composition（The pharmaceutical composition lot number of embodiment 1
20091124）, Herba Menthae, borneol, Radix Glycyrrhizae.
1.3 medications (1) replenishing YIN and removing heat soup is Chinese herbs decoction, and daily 1 dose, every dose of medicine 2g is decocted 2 times, and 200 are decocted every time
Ml, it is oral at twice after mixing of boiling medicine twice, 1 month is continuously taken for 1 course for the treatment of.(2) Chinese medical collutory only makes in the recurrence phase
With, 2-3 time/d, each 10-15 ml, rinsing the mouth 1-2 min.
1.4 efficacy assessment standard
Formulate according to Chinese stomatology meeting oral mucosal disease Professional Committee《Recurrent aphtha therapeutic evaluation is tried
Standard》.It more than 1 year is recovery from illness that oral ulcer terminates recurrence；Total intermittent time extends, and total ulcer number is reduced to effective；Total interval
Time lengthening, but always ulcer number is not reduced, or total intermittent time is without change, but total ulcer number is reduced, and is effective；Total intermittent time
And total ulcer number is without change, is invalid.
2 results
This group is followed the trail of after a course for the treatment of of taking medicine and paid a return visit, and is fully recovered 22, effective 12, effective 5, invalid 1, total effective rate
For 97.5%.
The pharmaceutical composition efficacy result of table 1
| Recovery from illness | It is effective | Effectively | It is invalid | Total effective rate（%） | |
| Pharmaceutical composition | 22 | 12 | 5 | 1 | 97.5 |
As a result show, medicine composite for curing recurrent oral ulceration is evident in efficacy.
Claims (8)
1. a kind of pharmaceutical composition for treating recurrent oral ulceration, it is characterised in that make the crude drug of the pharmaceutical composition
Composition and weight portion are：
Herba Fimbristylis dichotomae 481-487 weight portion Herba Dichrocephalae auriculatae 264-268 weight portion asarinin 42-48 weight portion Homoplantaginin 34-36
Weight portion peonidin 8-10 weight portions.
2. a kind of pharmaceutical composition for treating recurrent oral ulceration according to claim 1, it is characterised in that make the medicine
The composition and weight portion of the crude drug of compositions be：
The weight portion flower of Paeonia lactiflora Pal1. of 45 weight portion Homoplantaginin of Herba Fimbristylis dichotomae 484 weight portion Herba Dichrocephalae auriculatae, 266 weight portion asarinin 35
Blue or green plain 9 weight portion.
3. a kind of pharmaceutical composition for treating recurrent oral ulceration according to claim 1, it is characterised in that drug regimen
Thing can adopt the conventional method of galenic pharmacy to prepare piece agent or capsule or drop pill.
4. a kind of pharmaceutical composition for treating recurrent oral ulceration according to claim 1, it is characterised in that drug regimen
The treatment recurrent oral ulceration medicine that thing is constituted with chemical drugs or Chinese medicine.
5. a kind of preparation method of the pharmaceutical composition for treating recurrent oral ulceration, it is characterised in that prepare as follows：
The composition and weight portion of crude drug be：Herba Fimbristylis dichotomae 481-487 weight portion Herba Dichrocephalae auriculatae 264-268 weight portion asarinins
42-48 weight portion Homoplantaginin 34-36 weight portion peonidin 8-10 weight portions；
Preparation method：
（1）Herba Fimbristylis dichotomae, Herba Dichrocephalae auriculatae, asarinin, Homoplantaginin, peonidin are taken by crude drug proportioning, is mixed, with weight hundred
Divide the ethanol of specific concentration 52% as solvent, 34 DEG C of warm macerating are extracted, extraction time is 8 times, each extraction time is 7 hours, molten every time
Agent consumption is 17 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into relatively close
Degree 1.11, filtration, medicinal liquid is first washed with water by HPD750 macroporous adsorptive resins, then with the ethanol of weight percent concentration 44%
Eluant solution HPD750 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 44%, reclaim ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 64% as solvent, heating and refluxing extraction 6 times, carries every time
The time is taken for 0.6 hour, each solvent load is 14 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned
Ethanol is received, relative density 1.16 is concentrated into, is filtered, medicinal liquid is first washed with water by LK07 macroporous adsorptive resins, then uses weight
The ethanol solution eluting LK07 macroporous adsorptive resins of percent concentration 56%, collect the ethanol elution of weight percent concentration 56%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition for treating recurrent oral ulceration according to claim 5, its feature exists
Prepare in as follows：
The composition and weight portion of crude drug be：The weight portion of 484 weight portion Herba Dichrocephalae auriculatae of Herba Fimbristylis dichotomae, 266 weight portion asarinin 45
The weight portion of 35 weight portion peonidin of Homoplantaginin 9；
Preparation method：
（1）Herba Fimbristylis dichotomae, Herba Dichrocephalae auriculatae, asarinin, Homoplantaginin, peonidin are taken by crude drug proportioning, is mixed, with weight hundred
Divide the ethanol of specific concentration 52% as solvent, 34 DEG C of warm macerating are extracted, extraction time is 8 times, each extraction time is 7 hours, molten every time
Agent consumption is 17 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into relatively close
Degree 1.11, filtration, medicinal liquid is first washed with water by HPD750 macroporous adsorptive resins, then with the ethanol of weight percent concentration 44%
Eluant solution HPD750 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 44%, reclaim ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 64% as solvent, heating and refluxing extraction 6 times, carries every time
The time is taken for 0.6 hour, each solvent load is 14 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned
Ethanol is received, relative density 1.16 is concentrated into, is filtered, medicinal liquid is first washed with water by LK07 macroporous adsorptive resins, then uses weight
The ethanol solution eluting LK07 macroporous adsorptive resins of percent concentration 56%, collect the ethanol elution of weight percent concentration 56%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition for treating recurrent oral ulceration according to claim 5, its feature exists
In pharmaceutical composition the conventional method of galenic pharmacy can be adopted to prepare piece agent or capsule or drop pill.
8. a kind of preparation method of the pharmaceutical composition for treating recurrent oral ulceration according to claim 5, its feature exists
In pharmaceutical composition and chemical drugs or Chinese medicine composition treatment recurrent oral ulceration medicine.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611133221.1A CN106581357A (en) | 2016-12-10 | 2016-12-10 | Pharmaceutical composition for treatment of recurrent oral ulcer |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611133221.1A CN106581357A (en) | 2016-12-10 | 2016-12-10 | Pharmaceutical composition for treatment of recurrent oral ulcer |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107937336A (en) * | 2017-11-21 | 2018-04-20 | 钟弦 | A kind of application of the cyperaquinone and the like in terms of stem cell Osteoblast Differentiation is induced |
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2016
- 2016-12-10 CN CN201611133221.1A patent/CN106581357A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107937336A (en) * | 2017-11-21 | 2018-04-20 | 钟弦 | A kind of application of the cyperaquinone and the like in terms of stem cell Osteoblast Differentiation is induced |
| CN107937336B (en) * | 2017-11-21 | 2018-11-13 | 吉林省汇融生物科技有限公司 | A kind of application of the cyperaquinone and the like in terms of inducing stem cell Osteoblast Differentiation |
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