CN103341145A - Traditional Chinese medicine for treating psoriasis and preparation method thereof - Google Patents
Traditional Chinese medicine for treating psoriasis and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of medicines and in particular relates to a traditional Chinese medicine for treating psoriasis and a preparation method thereof. The traditional Chinese medicine for treating psoriasis is prepared from the following bulk pharmaceutical chemicals: rehmannia root, glossy privet fruit, eclipta, medlar, radix ophiopogonis, lalang grass rhizome, lithospermum, honeysuckle, fructus forsythiae, red paeony root, moutan bark, isatis root, dandelion, Chinese violet, fructus kochiae, cortex dictamni, sophora flavescens, zaocys dhumnade, cicada slough, rhizoma smilacis glabrae, coix seed, raw fructus aurantii, radix glehniae, lily, folium isatidis, sophora flower, dahurian patrinia herb, indigo naturalis, cornu bubali powder, salviae miltiorrhizae, dried ginger, fineleaf schizonepeta herb, divaricate saposhnikovia root, Chinese angelica, raw white paeony root and golden cypress. The traditional Chinese medicine for treating psoriasis has the effects of nourishing Yin and moistening dryness, nourishing blood, removing heat to cool blood as well as dispelling wind and arresting itching and is used for treating blood dryness type, blood deficiency type and blood fever type psoriasis caused by deficiency of kidney yin.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of psoriatic Chinese medicine and preparation method thereof for the treatment of.
Background technology
Psoriasis is commonly called as " psoriasis ", is a kind of common refractory skin of chronic easy with characteristic skin lesion, and old children irrespective of sex all can be ill.The patient is more and more in recent years.Psoriasis is all multifactor relevant with heredity, immunity, infection, physics, spirit, life, environment etc.The traditional Chinese medical science belongs to " white defect ", " chronic eczema " category.Morbidity is common in person between twenty and fifty, and skin lesion is stretched side, tail sacrum portion based on scalp, trunk and extremity.
Each psoriasis pustulosa case, the overwhelming majority are to adopt a large amount of hormone long-term treatments, are difficult to thoroughly cure, and easily outbreak or the state of an illness increase the weight of gradually repeatedly.
The medicine for the treatment of psoriasis dispelling wind for relieving itching commonly used, though the method that these medicines just take stopgap measures is temporary transient onset, recurrence easily.
Patent CN103110851A discloses a kind of psoriatic Chinese medicine composition for the treatment of, mainly formed by Herba Schizonepetae, Radix Saposhnikoviae, Pericarpium Zanthoxyli, Radix Gentianae, Periostracum Cicadae, Cortex Dictamni, the Fructus Kochiae, Semen Coicis, Zaocys, Cortex Moutan, Radix Ophiopogonis, Radix Paeoniae Rubra, Fructus Forsythiae, Radix Salviae Miltiorrhizae, Herba Taraxaci, Semen Persicae, Cortex Phellodendri, Rhizoma Polygoni Cuspidati, this invention Chinese medicine composition can effectively be alleviated the erythra symptom that is caused by psoriasis, and has effect antipruritic, pain relieving, psoriasis is had good therapeutical effect, is the psoriatic Chinese medicine composition of a kind for the treatment of safe and effective and without any side effects.But the Chinese medicine of this invention needs to decoct, and dosage is big, the medicine that dispels the wind for heat-clearing and toxic substances removing of the Chinese medicine of this invention great majority in addition, and taste is hardship relatively, takes earnestly, and the patient is not easy acceptance.
Summary of the invention
In order to solve above-mentioned technical problem, the invention provides a kind of psoriatic Chinese medicine composition and preparation method thereof for the treatment of.
The present invention realizes by following technical scheme:
A kind ofly treat psoriatic Chinese medicine, made by following bulk drugs:
Radix Rehmanniae 80-120 part, Fructus Ligustri Lucidi 10-20 part, Herba Ecliptae 10-20 part, Fructus Lycii 10-20 part, Radix Ophiopogonis 15-25 part, Rhizoma Imperatae 20-40 part, Radix Arnebiae (Radix Lithospermi) 20-40 part, Flos Lonicerae 15-25 part, Fructus Forsythiae 15-25 part, Radix Paeoniae Rubra 15-25 part, Cortex Moutan 15-25 part, Radix Isatidis 20-40 part, Herba Taraxaci 15-25 part, Herba Violae 15-25 part, Fructus Kochiae 20-40 part, Cortex Dictamni 20-40 part, Radix Sophorae Flavescentis 45-55 part, Zaocys 5-15 part, Periostracum Cicadae 5-15 part, Rhizoma Smilacis Glabrae 20-40 part, Semen Coicis 20-40 part, living Fructus Aurantii 15-25 part, Radix Glehniae 80-120 part, Bulbus Lilii 80-120 part, Folium Isatidis 20-40 part, Flos Sophorae 45-55 part, Herba Patriniae 15-25 part, Indigo Naturalis 45-55 part, Cornu Bubali powder 45-55 part, Radix Salviae Miltiorrhizae 10-20 part, Rhizoma Zingiberis 3-7 part, Herba Schizonepetae 3-7 part, Radix Saposhnikoviae 3-7 part, Radix Angelicae Sinensis 3-7 part, Radix Paeoniae Alba 3-7 part, Cortex Phellodendri 3-7 part.
Preferably, the psoriatic Chinese medicine of above-mentioned treatment, made by following bulk drugs:
Radix Rehmanniae 90-110 part, Fructus Ligustri Lucidi 13-17 part, Herba Ecliptae 13-17 part, Fructus Lycii 13-17 part, Radix Ophiopogonis 18-22 part, Rhizoma Imperatae 25-35 part, Radix Arnebiae (Radix Lithospermi) 25-35 part, Flos Lonicerae 18-22 part, Fructus Forsythiae 18-22 part, Radix Paeoniae Rubra 18-22 part, Cortex Moutan 18-22 part, Radix Isatidis 25-35 part, Herba Taraxaci 18-22 part, Herba Violae 18-22 part, Fructus Kochiae 25-35 part, Cortex Dictamni 25-35 part, Radix Sophorae Flavescentis 45-55 part, Zaocys 8-12 part, Periostracum Cicadae 8-12 part, Rhizoma Smilacis Glabrae 25-35 part, Semen Coicis 25-35 part, living Fructus Aurantii 18-22 part, Radix Glehniae 90-110 part, Bulbus Lilii 90-110 part, Folium Isatidis 25-35 part, Flos Sophorae 45-55 part, Herba Patriniae 18-22 part, Indigo Naturalis 45-55 part, Cornu Bubali powder 45-55 part, Radix Salviae Miltiorrhizae 13-17 part, Rhizoma Zingiberis 4-6 part, Herba Schizonepetae 4-6 part, Radix Saposhnikoviae 4-6 part, Radix Angelicae Sinensis 4-6 part, Radix Paeoniae Alba 4-6 part, Cortex Phellodendri 4-6 part.
Preferred, the psoriatic Chinese medicine of above-mentioned treatment, made by following bulk drugs:
100 parts in the Radix Rehmanniae, 15 parts of Fructus Ligustri Lucidi, 15 parts of Herba Ecliptaes, 15 parts of Fructus Lycii, 20 parts of Radix Ophiopogonis, 30 parts of Rhizoma Imperataes, 30 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts of Flos Loniceraes, 20 parts of Fructus Forsythiaes, 20 parts of Radix Paeoniae Rubra, 20 parts of Cortex Moutans, 30 parts of Radix Isatidis, 20 parts of Herba Taraxacis, 20 parts of Herba Violaes, 30 parts of the Fructus Kochiae, 30 parts of Cortex Dictamni, 50 parts of Radix Sophorae Flavescentiss, 10 parts of Zaocyss, 10 parts of Periostracum Cicadaes, 30 parts of Rhizoma Smilacis Glabraes, 30 parts of Semen Coiciss, 20 parts of living Fructus Aurantiis, 100 parts of Radix Glehniaes, 100 parts of Bulbus Liliies, 30 parts of Folium Isatidiss, 50 parts in Flos Sophorae, 20 parts of Herba Patriniae, 50 parts of Indigo Naturaliss, 50 parts of Cornu Bubali powders, 15 parts of Radix Salviae Miltiorrhizaes, 5 parts of Rhizoma Zingiberiss, 5 parts of Herba Schizonepetae, 5 parts of Radix Saposhnikoviaes, 5 parts of Radix Angelicae Sinensis, 5 parts of Radix Paeoniae Alba, 5 parts of Cortex Phellodendris.
The present invention treats each crude drug of psoriatic Chinese medicine and is the kind that pharmacopeia or Chinese materia medica textbook are put down in writing.
In above composition the of the present invention, the weight of each medicine of distinguishing the flavor of is calculated with crude drug, if be unit with the gram, as makes preparation, then can be made into the 100-1000 agent because of varying in size of preparation.Described 100-1000 agent refers to the dosage form of unit dose, as tablet 100-1000 sheet, and capsule 100-1000 grain, granule l00-1000 part, oral liquid l00-l000ml, unguentum l00-l000 part, pill 10-1000 ball etc.
More than form to be by weight as proportioning, when producing, can or reduce according to the corresponding proportion increase, can be raw material weight unit with the kilogram as large-scale production, or be unit with the ton, small-scale production can be unit with the gram also, weight can increase or reduce, but the constant rate of weight proportion between each composition.
The psoriatic Chinese medicine of above-mentioned treatment, the dosage form of described Chinese medicine are oral formulations.These oral formulations dosage forms are selected from: tablet, capsule, oral liquid, suck agent, granule, pill, powder, preferably capsule and tablet.
The psoriatic Chinese medicine for the treatment of of the present invention, can be to process through extraction or other modes by the raw material of Chinese medicine medical material that above-mentioned prescription is formed, make middle pharmaceutically active substance, subsequently, be raw material with pharmaceutically active substance in this, add the medicine acceptable carrier when needing, make according to the routine techniques of galenic pharmacy.Described active substance can obtain by extracting raw material of Chinese medicine respectively, also can obtain by common extraction raw material of Chinese medicine medical material, also can obtain by other means, as: by pulverize, squeeze, grind, sieve, method such as percolation, extraction, water are carried, alcohol extraction, ester are carried, chromatography obtains, these active substances can be the material of extractum form, can be that dry extract also can be fluid extract, make different concentration according to the different needs decision of preparation.
The present invention treats psoriatic Chinese medicine, and its pharmaceutically active substance makes through extracting processing, as processing in order to following method:
Above medicine is pulverized, incapsulates,
Or
Above medicine is pulverized or through decocting in water, is obtained water extract, is condensed into cream, is raw material with this clear paste, adds the medicine acceptable carrier when needing, and makes according to the routine techniques of galenic pharmacy.
The medicine acceptable carrier comprises diluent, excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant of pharmaceutical field routine etc.These medicine acceptable carriers are selected from: Mel, refined honey, mannitol, sorbitol, sorbic acid or potassium salt, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin A, vitamin C, the main plain E of dimension, vitamin D, azone, the EDTA disodium, EDTA calcium sodium, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, propylene glycol, ethanol, polysorbate60-80, span-80, Cera Flava, lanoline, liquid paraffin, hexadecanol, gallate ester, fine jade, triethanolamine, basic amino acid, carbamide, allantoin, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, the phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Preferably, the psoriatic Chinese medicine of above-mentioned treatment, described middle pharmaceutically active substance preparation method is:
(a) Flos Lonicerae, Fructus Forsythiae, Cortex Moutan, Zaocys, Periostracum Cicadae, Semen Coicis, living Fructus Aurantii, Flos Sophorae, Indigo Naturalis, Cornu Bubali powder, Cortex Phellodendri are pulverized and are superfine powder, and superfine powder particle size range 5-45 μ m gets fine drug powder;
(b) Radix Rehmanniae, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Lycii, Radix Ophiopogonis, Rhizoma Imperatae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Radix Isatidis, Herba Taraxaci, Herba Violae, the Fructus Kochiae, Cortex Dictamni, Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae, Radix Glehniae, Bulbus Lilii, Folium Isatidis, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Zingiberis, Herba Schizonepetae, Radix Saposhnikoviae, Radix Angelicae Sinensis, Radix Paeoniae Alba are decocted with water 2 times, 8 times of water that add for the first time medical material weight, decocted 1.5 hours, add for the second time 6 times of water of medical material weight, decocted 1 hour, merge decoction liquor, filter, it is 1.12～1.19 that filtrate is concentrated into relative density; Add ethanol then and make that to contain alcohol amount be 80%, leave standstill after 8-10 hour and filter, filtrate 55-60 ℃ concentrating under reduced pressure is concentrated into the clear paste that relative density is 1.20-1.30, and clear paste is 180-200 ℃ in the spray dryer inlet temperature, outlet temperature is 70-90 ℃, under the moisture 8% following condition, carry out spray drying, the granule that spray drying obtains is pulverized, cross 80 mesh sieves, get the drug spray xeraphium;
(c) the drug spray xeraphium that makes of the fine drug powder that step (a) is made and step (b), mix homogeneously namely gets pharmaceutically active substance among the present invention.
Chinese medicine preparation of the present invention, when making medicament, the medicament of unit dose can contain middle pharmaceutically active substance 0.1 ~ l000mg of the present invention, and all the other are pharmaceutically acceptable carrier.Pharmaceutically acceptable carrier can be the 0.01-99.9% of total formulation weight amount by weight.
Pharmaceutical preparation of the present invention is determined usage and dosage according to patient's situation in use.Instructions of taking due to illness people's body constitution situation is taken to the ill, as obeying 1-4 time each 1-10 grain/sheet day.
The most preferred prescription of the present invention and preparation method are listed in the embodiment of the invention.
The psoriatic Chinese medicine for the treatment of of the present invention, have nourshing Yin and drynsessmoistening prescriptionly nourish blood, the effect of clearing away heat and cooling blood, dispelling wind for relieving itching, be used for the dry blood deficiency blood-heat type of the blood psoriasis that deficiency of the kidney yin causes.
Take points for attention: 1. the anemia of pregnant woman prohibits clothes, the careful clothes of child.2. careful clothes of weak, chronic gastrointestinal disease patient.3. the careful usefulness of allergic constitution person.4. period in a medicine is avoided ichthyophagy, shrimp, beef and mutton, gives up alcohol and pungent stimulation food.
The inventor passes through the clinical observation in year surplus in the of 10, and a large amount of psoriatics about 97% is the dry blood-heat type of blood, and namely 97% psoriatic belongs to the indication scope that the present invention treats psoriatic Chinese medicine, can use the present invention separately and treat psoriatic Chinese medicine.Have about 1% to be the scorching hot septicopyemia type that transforms into of pyretic toxicity, primary disease is in a bad way, and needs oral the present invention to treat psoriatic Chinese medicine use in conjunction anti-infective Drug therapy.Also have 2% to be psoriasis inveterata, patient's skin lesion place is dark red, and skin lesion is big lamellar, and cortex is thick, matter such as leather, on cover a small amount of white scales, skin cannot not itched heavyly, this kind of psoriatic, may be with long-term outer to be coated with multiple antipruritic relevant, treat this kind of psoriasis, need the present invention to treat psoriatic Chinese medicine use in conjunction immunoregulation medicament, slowly conditioning.
The prescription theory of Chinese medical science basis that the present invention treats psoriatic Chinese medicine is:
(1) the kidney being a ZANG-organ containing both water and fire, the kidney Kidney-Yin kidney-Yang of residing, for the whole body root of YIN and YANG this, be the cradle of the vital organs of the human body.Kidney yin is basis of the cloudy liquid of human body, and non-this of the moon of the vital organs of the human body can not nourish.The negative and positive of kidney are lost void can involve the five internal organs, and the five internal organs are also hindered " must reach kidney thoroughly ", and the psoriasis course of disease is long, repeatedly the outbreak, xerosis cutis does not heal all the year round, the kidney usually involved in chronic disease, the treatment psoriasis must ask with this, from the conditioning deficiency of the kidney yin start with.
(2) the kidney promoting blood generates, kidney storing essence, and the smart marrow of giving birth to, the marrow hemopoietic, kidney essense can be changed and be blood, participates in the generation of blood, so saying of " source of blood being kidney " arranged.Psoriatic clinical manifestation, it is dry to be mainly blood, and starting with from the conditioning kidney yin to obtain good effect, has only balance kidney yin kidney yang, could stop psoriatic outbreak repeatedly.
(3) kidney qi forked rubbing, kidney yin and kidney yang are the basic of other internal organs negative and positive of whole body, the internal organs QI and blood are had promote and regulating action.Psoriatic clinical manifestation is dry based on blood, though relevant with each internal organs, principal element is deficiency of the kidney yin.The present invention treats the compatibility of psoriatic Chinese medicine, based on YIN nourishing, seeks the combination of the best Yin-nourishing drug Radix Rehmanniae, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Lycii, Radix Ophiopogonis, Radix Glehniae, Bulbus Lilii; Again because of psoriatic's skin lesion place, hands touches burning sensation, and skin lesion place skin bright red, resembling of heat arranged, so be aided with product Flos Lonicerae, Fructus Forsythiae, Cortex Moutan, Zaocys, Periostracum Cicadae, Flos Sophorae, Indigo Naturalis, Rheum alexandrae Batal. cypress, Rhizoma Imperatae, Radix Arnebiae (Radix Lithospermi), Radix Isatidis, Herba Taraxaci, Herba Violae, the Fructus Kochiae, Cortex Dictamni, Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae, Folium Isatidis, the Herba Patriniae of clearing away heat and cooling blood; Pyretic toxicity is strongly fragrant not to be understood for a long time, then easily consumes impairment of YIN blood, hematogenous blockage, and blood-stasis internal-depression causes failure of skin and muscle to be nourished, is " outer disease is gone into network ", " prolonged illness becomes the stasis of blood ", therefore needs with Radix Angelicae Sinensis, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra nourshing blood and promoting blood circulation removing heat from blood; Blood-deficiency and wind-dry, so psoriasis is itched more, skin falls to consider to be worth doing a lot of, so add Herba Schizonepetae, Radix Saposhnikoviae, horn powder dispelling wind for relieving itching; The thing of YIN nourishing hinders stomach more, uses imapirment of the spleen and stomach for a long time, so add the medicine Semen Coicis of drying damp and strengthening spleen stomach function regulating, living Fructus Aurantii, Rhizoma Zingiberis.
The characteristics of showing effect repeatedly according to psoriasis are formulated with nourshing Yin and drynsessmoistening prescription and are nourished blood that to effect a permanent cure be the Therapeutic Principle, implied meaning " strengthening renal yin to inhibit predominant yang is with sunlight processed ".
Beneficial effect of the present invention is
(1) the invention provides the psoriatic Chinese medicine of a kind of new treatment, satisfied clinical needs.
(2) the present invention treats psoriatic Chinese medicine and is used for treating psoriasis, instant effect, and short treating period, the cure rate height, relapse rate is low, and untoward reaction is few.Cure 158 examples, a course cure rate 24.31% oral 1 course for the treatment of; Cure 204 examples, 2 course cure rates 31.38% oral 2 courses for the treatment of; Cure 172 examples, 3 course cure rates 26.46% oral 3 courses for the treatment of; Oral 3 the course for the treatment of produce effects 105 examples, oral 3 courses for the treatment of invalid 11 examples.The patient who cures followed up a case by regular visits to 3 years, recurred 4 people, relapse rate 0.75%.Total effective rate 98.31%, cure rate 82.16%, obvious effective rate 16.15%, inefficiency 1.69%.Do not see a routine untoward reaction among the 650 routine patients.
(3) psoriasis state of an illness stubbornness, the course of disease is long, need take medicine for a long time, in tcm clinical practice, use decoction at present always, patient needs boil medicine every year, and is cumbersome, and the many heat and toxic materials clearing away medicine in medicine the inside, mouthfeel is poor, be difficult for summer storing, the present invention will treat psoriatic medicine and be prepared into capsule or tablet after extracting processing, cover the bad smell of medicine, need eat several for each, drug administration and storage are convenient; Capsule or tablet volume are little, carry easily and store.
The specific embodiment
Below in conjunction with specific embodiment the present invention is done further explanation, so that those skilled in the art more understands the present invention, but therefore do not limit the present invention.
Embodiment 1 the present invention treats the preparation of psoriatic Chinese medicinal capsule agent
Radix Rehmanniae 100g, Fructus Ligustri Lucidi 15g, Herba Ecliptae 15g, Fructus Lycii 15g, Radix Ophiopogonis 20g, Rhizoma Imperatae 30g, Radix Arnebiae (Radix Lithospermi) 30g, Flos Lonicerae 20g, Fructus Forsythiae 20g, Radix Paeoniae Rubra 20g, Cortex Moutan 20g, Radix Isatidis 30g, Herba Taraxaci 20g, Herba Violae 20g, Fructus Kochiae 30g, Cortex Dictamni 30g, Radix Sophorae Flavescentis 50g, Zaocys 10g, Periostracum Cicadae 10g, Rhizoma Smilacis Glabrae 30g, Semen Coicis 30g, living Fructus Aurantii 20g, Radix Glehniae 100g, Bulbus Lilii 100g, Folium Isatidis 30g, Flos Sophorae 50g, Herba Patriniae 20g, Indigo Naturalis 50g, Cornu Bubali powder 50g, Radix Salviae Miltiorrhizae 15g, Rhizoma Zingiberis 5g, Herba Schizonepetae 5g, Radix Saposhnikoviae 5g, Radix Angelicae Sinensis 5g, Radix Paeoniae Alba 5g, Cortex Phellodendri 5g.Prepare 500 altogether.
Preparation method
(a) Flos Lonicerae, Fructus Forsythiae, Cortex Moutan, Zaocys, Periostracum Cicadae, Semen Coicis, living Fructus Aurantii, Flos Sophorae, Indigo Naturalis, Cornu Bubali powder, Cortex Phellodendri are pulverized and are superfine powder, and superfine powder particle size range 5-45 μ m gets fine drug powder;
(b) Radix Rehmanniae, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Lycii, Radix Ophiopogonis, Rhizoma Imperatae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Radix Isatidis, Herba Taraxaci, Herba Violae, the Fructus Kochiae, Cortex Dictamni, Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae, Radix Glehniae, Bulbus Lilii, Folium Isatidis, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Zingiberis, Herba Schizonepetae, Radix Saposhnikoviae, Radix Angelicae Sinensis, Radix Paeoniae Alba are decocted with water 2 times, 8 times of water that add for the first time medical material weight, decocted 1.5 hours, add for the second time 6 times of water of medical material weight, decocted 1 hour, merge decoction liquor, filter, it is 1.12～1.19 that filtrate is concentrated into relative density; Add ethanol then and make that to contain alcohol amount be 80%, leave standstill after 9 hours and filter, 55 ℃ of concentrating under reduced pressure of filtrate are concentrated into the clear paste that relative density is 1.20-1.30, and clear paste is 180 ℃ in the spray dryer inlet temperature, outlet temperature is 70 ℃, under the moisture 8% following condition, carry out spray drying, the granule that spray drying obtains is pulverized, cross 80 mesh sieves, get the drug spray xeraphium;
(c) the drug spray xeraphium that makes of the fine drug powder that step (a) is made and step (b), mix homogeneously gets pharmaceutically active substance among the present invention;
(d) active component of Chinese medicine composition of the present invention adds dextrin, magnesium stearate etc., and dry granulation is crossed 60 mesh sieves, No. 00 capsule of packing into get final product capsule.
Usage and dosage: each 4-5 grain, every day 3 times.30 days is a course for the treatment of.
Embodiment 2 the present invention treat the preparation of psoriatic Chinese medicinal tablet
Prescription: Radix Rehmanniae 110g, Fructus Ligustri Lucidi 13g, Herba Ecliptae 17g, Fructus Lycii 13g, Radix Ophiopogonis 22g, Rhizoma Imperatae 25g, Radix Arnebiae (Radix Lithospermi) 35g, Flos Lonicerae 18g, Fructus Forsythiae 22g, Radix Paeoniae Rubra 18g, Cortex Moutan 22g, Radix Isatidis 25g, Herba Taraxaci 22g, Herba Violae 18g, Fructus Kochiae 35g, Cortex Dictamni 25g, Radix Sophorae Flavescentis 5g, Zaocys 8g, Periostracum Cicadae 12g, Rhizoma Smilacis Glabrae 25g, Semen Coicis 35g, living Fructus Aurantii 18g, Radix Glehniae 110g, Bulbus Lilii 90g, Folium Isatidis 35g, Flos Sophorae 45g, Herba Patriniae 22g, Indigo Naturalis 45g, Cornu Bubali powder 55g, Radix Salviae Miltiorrhizae 13g, Rhizoma Zingiberis 6g, Herba Schizonepetae 4g, Radix Saposhnikoviae 6g, Radix Angelicae Sinensis 4g, Radix Paeoniae Alba 6g, Cortex Phellodendri 4g.Prepare 500 altogether.
Preparation method
(a) Flos Lonicerae, Fructus Forsythiae, Cortex Moutan, Zaocys, Periostracum Cicadae, Semen Coicis, living Fructus Aurantii, Flos Sophorae, Indigo Naturalis, Cornu Bubali powder, Cortex Phellodendri are pulverized and are superfine powder, and superfine powder particle size range 5-45 μ m gets fine drug powder;
(b) Radix Rehmanniae, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Lycii, Radix Ophiopogonis, Rhizoma Imperatae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Radix Isatidis, Herba Taraxaci, Herba Violae, the Fructus Kochiae, Cortex Dictamni, Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae, Radix Glehniae, Bulbus Lilii, Folium Isatidis, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Zingiberis, Herba Schizonepetae, Radix Saposhnikoviae, Radix Angelicae Sinensis, Radix Paeoniae Alba are decocted with water 2 times, 8 times of water that add for the first time medical material weight, decocted 1.5 hours, add for the second time 6 times of water of medical material weight, decocted 1 hour, merge decoction liquor, filter, it is 1.12～1.19 that filtrate is concentrated into relative density; Add ethanol then and make that to contain alcohol amount be 80%, leave standstill after 8 hours and filter, 60 ℃ of concentrating under reduced pressure of filtrate are concentrated into the clear paste that relative density is 1.20-1.30, and clear paste is 200 ℃ in the spray dryer inlet temperature, outlet temperature is 90 ℃, under the moisture 8% following condition, carry out spray drying, the granule that spray drying obtains is pulverized, cross 80 mesh sieves, get the drug spray xeraphium;
(c) the drug spray xeraphium that makes of the fine drug powder that step (a) is made and step (b), mix homogeneously gets pharmaceutically active substance among the present invention;
(d) active component of Chinese medicine composition of the present invention adds starch, and mix homogeneously with the moistening of an amount of 80% (v/v) ethanol, soft material processed, is crossed 30 mesh sieves and granulated, in 75 ℃ of dryings, with 60 mesh sieve granulate, tabletting, sugar coating, packing, outer package, it is qualified to inspect by ready samples, gets tablet.
Usage and dosage: each 4-5 sheet, every day 3 times.30 days is a course for the treatment of.
Embodiment 3 the present invention treat the preparation of psoriatic Chinese medicinal capsule agent
Prescription: Radix Rehmanniae 90g, Fructus Ligustri Lucidi 17g, Herba Ecliptae 13g, Fructus Lycii 17g, Radix Ophiopogonis 18g, Rhizoma Imperatae 35g, Radix Arnebiae (Radix Lithospermi) 25g, Flos Lonicerae 22g, Fructus Forsythiae 18g, Radix Paeoniae Rubra 22g, Cortex Moutan 18g, Radix Isatidis 35g, Herba Taraxaci 18g, Herba Violae 22g, Fructus Kochiae 25g, Cortex Dictamni 35g, Radix Sophorae Flavescentis 45g, Zaocys 12g, Periostracum Cicadae 8g, Rhizoma Smilacis Glabrae 35g, Semen Coicis 25g, living Fructus Aurantii 22g, Radix Glehniae 90g, Bulbus Lilii 110g, Folium Isatidis 25g, Flos Sophorae 55g, Herba Patriniae 18g, Indigo Naturalis 55g, Cornu Bubali powder 45g, Radix Salviae Miltiorrhizae 17g, Rhizoma Zingiberis 4g, Herba Schizonepetae 6g, Radix Saposhnikoviae 4g, Radix Angelicae Sinensis 6g, Radix Paeoniae Alba 4g, Cortex Phellodendri 6g.Prepare 500 altogether.
Preparation method
(a) Flos Lonicerae, Fructus Forsythiae, Cortex Moutan, Zaocys, Periostracum Cicadae, Semen Coicis, living Fructus Aurantii, Flos Sophorae, Indigo Naturalis, Cornu Bubali powder, Cortex Phellodendri are pulverized and are superfine powder, and superfine powder particle size range 5-45 μ m gets fine drug powder;
(b) Radix Rehmanniae, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Lycii, Radix Ophiopogonis, Rhizoma Imperatae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Radix Isatidis, Herba Taraxaci, Herba Violae, the Fructus Kochiae, Cortex Dictamni, Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae, Radix Glehniae, Bulbus Lilii, Folium Isatidis, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Zingiberis, Herba Schizonepetae, Radix Saposhnikoviae, Radix Angelicae Sinensis, Radix Paeoniae Alba are decocted with water 2 times, 8 times of water that add for the first time medical material weight, decocted 1.5 hours, add for the second time 6 times of water of medical material weight, decocted 1 hour, merge decoction liquor, filter, it is 1.12～1.19 that filtrate is concentrated into relative density; Add ethanol then and make that to contain alcohol amount be 80%, leave standstill after 12 hours and filter, 55 ℃ of concentrating under reduced pressure of filtrate are concentrated into the clear paste that relative density is 1.20-1.30, and clear paste is 180 ℃ in the spray dryer inlet temperature, outlet temperature is 70 ℃, under the moisture 8% following condition, carry out spray drying, the granule that spray drying obtains is pulverized, cross 80 mesh sieves, get the drug spray xeraphium;
(c) the drug spray xeraphium that makes of the fine drug powder that step (a) is made and step (b), mix homogeneously gets pharmaceutically active substance among the present invention;
(d) active component of Chinese medicine composition of the present invention adds dextrin, magnesium stearate etc., and dry granulation is crossed 60 mesh sieves, No. 00 capsule of packing into get final product capsule.
Usage and dosage: each 4-5 grain, every day 3 times.30 days is a course for the treatment of.
Embodiment 4 the present invention treat the preparation of psoriatic Chinese medicinal tablet
Prescription: Radix Rehmanniae 120g, Fructus Ligustri Lucidi 10g, Herba Ecliptae 20g, Fructus Lycii 10g, Radix Ophiopogonis 25g, Rhizoma Imperatae 20g, Radix Arnebiae (Radix Lithospermi) 40g, Flos Lonicerae 15g, Fructus Forsythiae 25g, Radix Paeoniae Rubra 15g, Cortex Moutan 25g, Radix Isatidis 20g, Herba Taraxaci 25g, Herba Violae 15g, Fructus Kochiae 40g, Cortex Dictamni 20g, Radix Sophorae Flavescentis 55g, Zaocys 5g, Periostracum Cicadae 15g, Rhizoma Smilacis Glabrae 20g, Semen Coicis 40g, living Fructus Aurantii 15g, Radix Glehniae 120g, Bulbus Lilii 80g, Folium Isatidis 40g, Flos Sophorae 45g, Herba Patriniae 25g, Indigo Naturalis 45g, Cornu Bubali powder 55g, Radix Salviae Miltiorrhizae 10g, Rhizoma Zingiberis 7g, Herba Schizonepetae 3g, Radix Saposhnikoviae 7g, Radix Angelicae Sinensis 3g, Radix Paeoniae Alba 7g, Cortex Phellodendri 3g.Prepare 500 altogether.
Preparation method is with embodiment 2.
Usage and dosage: each 4-5 grain, every day 3 times.30 days is a course for the treatment of.
Embodiment 5 the present invention treat the preparation of psoriatic Chinese medicinal capsule agent
Prescription: Radix Rehmanniae 80g, Fructus Ligustri Lucidi 20g, Herba Ecliptae 10g, Fructus Lycii 20g, Radix Ophiopogonis 15g, Rhizoma Imperatae 40g, Radix Arnebiae (Radix Lithospermi) 20g, Flos Lonicerae 25g, Fructus Forsythiae 15g, Radix Paeoniae Rubra 25g, Cortex Moutan 15g, Radix Isatidis 40g, Herba Taraxaci 15g, Herba Violae 25g, Fructus Kochiae 20g, Cortex Dictamni 40g, Radix Sophorae Flavescentis 45g, Zaocys 15g, Periostracum Cicadae 5g, Rhizoma Smilacis Glabrae 40g, Semen Coicis 20g, living Fructus Aurantii 25g, Radix Glehniae 80g, Bulbus Lilii 120g, Folium Isatidis 20g, Flos Sophorae 55g, Herba Patriniae 15g, Indigo Naturalis 55g, Cornu Bubali powder 45g, Radix Salviae Miltiorrhizae 20g, Rhizoma Zingiberis 3g, Herba Schizonepetae 7g, Radix Saposhnikoviae 3g, Radix Angelicae Sinensis 7g, Radix Paeoniae Alba 3g, Cortex Phellodendri 7g.Prepare 500 altogether.
Preparation method is with embodiment 1.
Usage and dosage: each 4-5 grain, every day 3 times.30 days is a course for the treatment of.
The psoriatic capsule for the treatment of to the embodiment of the invention 1 preparation has carried out clinical trial, and Details as Follows:
Physical data
Select 650 examples, the psoriatic that 1998-2010 goes to a doctor in here, male patient's 300 examples, female patient 350 examples, oldest patient 72 years old, the patient of age minimum 16 years old, 44 years old mean age.Wherein extremity are suffered from psoriasis person 208 examples, and shirtfront back head is suffered from psoriasis person 292 examples, and whole body is suffered from psoriasis person 150 examples, and the elder of the course of disease 20 years is the shortest 1 year.
Therapeutic Method: give Chinese medicinal composition capsules agent of the present invention, each 5, every day 3 times, 1 month was 1 course for the treatment of.
Efficacy determination: treat criterion after 1 course for the treatment of
Cure: psoriatic lesion disappears, preventing from scar;
Produce effects: psoriatic lesion disappears more than 70%;
Invalid: no significant change before and after the curing psoriasis.
Result: cure 158 examples, a course cure rate 24.31% oral 1 course for the treatment of; Cure 204 examples, 2 course cure rates 31.38% oral 2 courses for the treatment of; Cure 172 examples, 3 course cure rates 26.46% oral 3 courses for the treatment of; Oral 3 the course for the treatment of produce effects 105 examples, oral 3 courses for the treatment of invalid 11 examples.The patient who cures followed up a case by regular visits to 3 years, recurred 4 people, relapse rate 0.75%.
Total effective rate 98.31%, cure rate 82.16%, obvious effective rate 16.15%, inefficiency 1.69%.Do not see a routine untoward reaction among the 650 routine patients.
Model case:
Lee's tinkling of pieces of jade, woman, 20 years old, first visit on February 3 in 2002, readme was suffered from psoriasis 7 years, no obvious inducement before 7 years, and red point appears in anterior part of chest skin, shape such as sorghum grain, on cover white scales, skin is itched, after enlarge gradually, form lamellar, circle, skin lesion place color is red, on cover a large amount of lamellar white scales, come off layer by layer, itch night and increase the weight of, be developed to the shirtfront gradually, back part presents big lamellar skin lesion, is psoriasis after diagnosing.Once obeyed multiple Pharmaceuticals, and external use anti pruritic ointment, effect is all not good.Existing disease sees that head, shirtfront, back part present big lamellar skin lesion, circle, skin lesion place color is red, on cover a large amount of lamellars white thin skins, itching heavily in the skin lesion place, grabs a large amount of silver bits that then come off.The patient often catches a cold, pharyngeal pain, is hard and dry, and it is poor that stomach is received food, poor sleep (itch night weight), and body of the tongue is light red, tongue fur BOHUANG, pulse condition stringy and thready pulse.Dialectical is heat in blood blood-dryness type psoriasis, and the rule for the treatment of is nourshing Yin and drynsessmoistening prescription to nourish blood, the heat clearing away profit of holding concurrently blood-cooling itch-relieving.Give the present invention and treat psoriatic Chinese medicinal capsule, each 5, every day 3 times, 30 days was 1 course for the treatment of.After 1 course for the treatment of, patient's head, shirtfront, back part skin lesion disappear substantially, do not have and stay cicatrix, for consolidating curative effect, continue to give the present invention and treat psoriatic Chinese medicinal capsule, and each 4, every day 3 times, 30 days was 1 course for the treatment of.After continuing for 1 course for the treatment of, cicatrix is not stayed in the complete obiteration of patient's skin lesion, follows up a case by regular visits to and does not see recurrence in 10 years.
Certain English of side, woman, 16 years old, middle school student, first visit on May 10 in 2003.Suffered from psoriasis 4 years, increased the weight of 1 year.Existing two upper limb, two lower limb and head present large stretch of circular skin lesion, and skin lesion place color is red, on cover a large amount of lamellar white scales, grab a large amount of white scales that then come off, annual winter in spring, the state of an illness increased the weight of.All be diagnosed as psoriasis in how tame hospital, oral multiple Drug therapy once, the commentaries on classics of not getting better so far, stomach is received very, menstrual blood volume is on the low side, and it is dried partially to defecate, and body of the tongue is light red, and tongue fur is yellow partially, the pulse condition stringy and thready pulse, the dry blood-heat type of dialectical blood, the rule for the treatment of is nourshing Yin and drynsessmoistening prescription to nourish blood, the heat clearing away profit of holding concurrently blood-cooling itch-relieving.Give the present invention and treat psoriatic Chinese medicinal capsule, each 5, every day 3 times, 30 days was 1 course for the treatment of.After 1 course for the treatment of, patient's head, shirtfront, back part skin lesion disappear about 60%, and the good standard of two upper limb skin lesion is the most obvious, and skin is itched and alleviated, and whole body is light, no significant discomfort sense.After 1 course for the treatment of, two upper limb, two lower limb and head skin lesion all disappear, and also do not have cicatrix continue clothes, and skin is not itched, and has reached clinical cure.Follow up a case by regular visits to not recurrence in 9 years.
Yao's moral, man, 46 years old, first visit on April 2 in 2008 was suffered from psoriasis 1 year, and existing head, extremity, shirtfront, back all have skin lesion, skin lesion accounts for whole body about 60%, and skin is rounded, and is red as Semen arachidis hypogaeae size, skin lesion place cortex, on cover a large amount of white scales, skin is itched, increase the weight of night, rise morning and be covered with the white scales that comes off on the sheet, sleep can, it is dried partially to defecate, body of the tongue is light red, and the tongue heart is yellow partially, the pulse condition stringy and rolling pulse.Many tame hospital diagnosis are psoriasis, do not heal through multi-treatment.Give the present invention and treat psoriatic Chinese medicinal capsule, each 5, every day 3 times, 30 days was 1 course for the treatment of.After 1 course for the treatment of, patient's whole body skin lesion disappears about 80%, and skin is itched and subtracted greatly.After continuing for 1 course for the treatment of, cicatrix is not stayed in the complete obiteration of patient's skin lesion, follows up a case by regular visits to and does not see recurrence in 3 years.
Claims (8)
1. treat psoriatic Chinese medicine for one kind, made by following bulk drugs:
Radix Rehmanniae 80-120 part, Fructus Ligustri Lucidi 10-20 part, Herba Ecliptae 10-20 part, Fructus Lycii 10-20 part, Radix Ophiopogonis 15-25 part, Rhizoma Imperatae 20-40 part, Radix Arnebiae (Radix Lithospermi) 20-40 part, Flos Lonicerae 15-25 part, Fructus Forsythiae 15-25 part, Radix Paeoniae Rubra 15-25 part, Cortex Moutan 15-25 part, Radix Isatidis 20-40 part, Herba Taraxaci 15-25 part, Herba Violae 15-25 part, Fructus Kochiae 20-40 part, Cortex Dictamni 20-40 part, Radix Sophorae Flavescentis 45-55 part, Zaocys 5-15 part, Periostracum Cicadae 5-15 part, Rhizoma Smilacis Glabrae 20-40 part, Semen Coicis 20-40 part, living Fructus Aurantii 15-25 part, Radix Glehniae 80-120 part, Bulbus Lilii 80-120 part, Folium Isatidis 20-40 part, Flos Sophorae 45-55 part, Herba Patriniae 15-25 part, Indigo Naturalis 45-55 part, Cornu Bubali powder 45-55 part, Radix Salviae Miltiorrhizae 10-20 part, Rhizoma Zingiberis 3-7 part, Herba Schizonepetae 3-7 part, Radix Saposhnikoviae 3-7 part, Radix Angelicae Sinensis 3-7 part, Radix Paeoniae Alba 3-7 part, Cortex Phellodendri 3-7 part.
2. the psoriatic Chinese medicine for the treatment of according to claim 1 is characterized in that, is made by following bulk drugs:
Radix Rehmanniae 90-110 part, Fructus Ligustri Lucidi 13-17 part, Herba Ecliptae 13-17 part, Fructus Lycii 13-17 part, Radix Ophiopogonis 18-22 part, Rhizoma Imperatae 25-35 part, Radix Arnebiae (Radix Lithospermi) 25-35 part, Flos Lonicerae 18-22 part, Fructus Forsythiae 18-22 part, Radix Paeoniae Rubra 18-22 part, Cortex Moutan 18-22 part, Radix Isatidis 25-35 part, Herba Taraxaci 18-22 part, Herba Violae 18-22 part, Fructus Kochiae 25-35 part, Cortex Dictamni 25-35 part, Radix Sophorae Flavescentis 45-55 part, Zaocys 8-12 part, Periostracum Cicadae 8-12 part, Rhizoma Smilacis Glabrae 25-35 part, Semen Coicis 25-35 part, living Fructus Aurantii 18-22 part, Radix Glehniae 90-110 part, Bulbus Lilii 90-110 part, Folium Isatidis 25-35 part, Flos Sophorae 45-55 part, Herba Patriniae 18-22 part, Indigo Naturalis 45-55 part, Cornu Bubali powder 45-55 part, Radix Salviae Miltiorrhizae 13-17 part, Rhizoma Zingiberis 4-6 part, Herba Schizonepetae 4-6 part, Radix Saposhnikoviae 4-6 part, Radix Angelicae Sinensis 4-6 part, Radix Paeoniae Alba 4-6 part, Cortex Phellodendri 4-6 part.
3. the psoriatic Chinese medicine for the treatment of according to claim 2 is characterized in that, is made by following bulk drugs:
100 parts in the Radix Rehmanniae, 15 parts of Fructus Ligustri Lucidi, 15 parts of Herba Ecliptaes, 15 parts of Fructus Lycii, 20 parts of Radix Ophiopogonis, 30 parts of Rhizoma Imperataes, 30 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts of Flos Loniceraes, 20 parts of Fructus Forsythiaes, 20 parts of Radix Paeoniae Rubra, 20 parts of Cortex Moutans, 30 parts of Radix Isatidis, 20 parts of Herba Taraxacis, 20 parts of Herba Violaes, 30 parts of the Fructus Kochiae, 30 parts of Cortex Dictamni, 50 parts of Radix Sophorae Flavescentiss, 10 parts of Zaocyss, 10 parts of Periostracum Cicadaes, 30 parts of Rhizoma Smilacis Glabraes, 30 parts of Semen Coiciss, 20 parts of living Fructus Aurantiis, 100 parts of Radix Glehniaes, 100 parts of Bulbus Liliies, 30 parts of Folium Isatidiss, 50 parts in Flos Sophorae, 20 parts of Herba Patriniae, 50 parts of Indigo Naturaliss, 50 parts of Cornu Bubali powders, 15 parts of Radix Salviae Miltiorrhizaes, 5 parts of Rhizoma Zingiberiss, 5 parts of Herba Schizonepetae, 5 parts of Radix Saposhnikoviaes, 5 parts of Radix Angelicae Sinensis, 5 parts of Radix Paeoniae Alba, 5 parts of Cortex Phellodendris.
4. according to claim 1 or the psoriatic Chinese medicine of 2 or 3 described treatments, it is characterized in that the dosage form of described Chinese medicine is oral formulations.
5. according to claim 1 or the psoriatic Chinese medicine of 2 or 3 described treatments, it is characterized in that the dosage form of described Chinese medicine is capsule.
6. according to claim 1 or the psoriatic Chinese medicine of 2 or 3 described treatments, it is characterized in that the dosage form of described Chinese medicine is tablet.
7. claim 1 or the psoriatic preparation method of Chinese medicine of 2 or 3 described treatments, it is characterized in that, the process following steps: the raw material of Chinese medicine medical material is processed through extraction or other modes, make middle pharmaceutically active substance, should mix with the medicine acceptable carrier separately by middle pharmaceutically active substance, namely can be made into according to the galenic pharmacy routine techniques.
8. the psoriatic preparation method of Chinese medicine for the treatment of according to claim 7 is characterized in that, described middle pharmaceutically active substance preparation method is:
(a) Flos Lonicerae, Fructus Forsythiae, Cortex Moutan, Zaocys, Periostracum Cicadae, Semen Coicis, living Fructus Aurantii, Flos Sophorae, Indigo Naturalis, Cornu Bubali powder, Cortex Phellodendri are pulverized and are superfine powder, and superfine powder particle size range 5-45 μ m gets fine drug powder;
(b) Radix Rehmanniae, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Lycii, Radix Ophiopogonis, Rhizoma Imperatae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Radix Isatidis, Herba Taraxaci, Herba Violae, the Fructus Kochiae, Cortex Dictamni, Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae, Radix Glehniae, Bulbus Lilii, Folium Isatidis, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Zingiberis, Herba Schizonepetae, Radix Saposhnikoviae, Radix Angelicae Sinensis, Radix Paeoniae Alba are decocted with water 2 times, 8 times of water that add for the first time medical material weight, decocted 1.5 hours, add for the second time 6 times of water of medical material weight, decocted 1 hour, merge decoction liquor, filter, it is 1.12～1.19 that filtrate is concentrated into relative density; Add ethanol then and make that to contain alcohol amount be 80%, leave standstill after 8-10 hour and filter, filtrate 55-60 ℃ concentrating under reduced pressure is concentrated into the clear paste that relative density is 1.20-1.30, and clear paste is 180-200 ℃ in the spray dryer inlet temperature, outlet temperature is 70-90 ℃, under the moisture 8% following condition, carry out spray drying, the granule that spray drying obtains is pulverized, cross 80 mesh sieves, get the drug spray xeraphium;
(c) the drug spray xeraphium that makes of the fine drug powder that step (a) is made and step (b), mix homogeneously namely gets pharmaceutically active substance among the present invention.
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| CN103893649A (en) * | 2014-03-26 | 2014-07-02 | 叶葵 | Traditional Chinese medicine for treating psoriasis |
| CN104042978A (en) * | 2014-06-28 | 2014-09-17 | 蚌埠明日欣医药有限公司 | Traditional Chinese medicine mixture for treating pityriasis rosea |
| CN104984132A (en) * | 2015-07-22 | 2015-10-21 | 袁玥 | Traditional Chinese medicine for treating psoriasis caused by dampness |
| CN105521434A (en) * | 2015-11-30 | 2016-04-27 | 吕翠云 | Traditional Chinese medicine for treating head and face psoriasis |
| CN105687939A (en) * | 2016-04-09 | 2016-06-22 | 张志强 | Oral-administration traditional Chinese medicine for treating psoriasis and preparation method thereof |
| CN105902908A (en) * | 2016-04-24 | 2016-08-31 | 邹洪胜 | Traditional Chinese medicinal composition for treating psoriasis |
| CN110404027A (en) * | 2019-08-22 | 2019-11-05 | 张起江 | It is a kind of to treat dermopathic Chinese medicine composition and preparation method |
| CN114796139A (en) * | 2022-04-28 | 2022-07-29 | 阿克曼皮肤医院投资有限公司 | Traditional Chinese medicine pill for treating blood-heat psoriasis vulgaris |
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