CN101455712B - Traditional Chinese medicine composition for treating cerebral thrombosis and preparation method and use thereof - Google Patents
Traditional Chinese medicine composition for treating cerebral thrombosis and preparation method and use thereof Download PDFInfo
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Abstract
The invention discloses a Chinese traditional medicine composition treating cerebral thrombosis and a preparation method thereof. Radix astragali, rhizoma ligustici wallichii and earthworms are used as effective drug components, are concentrated to a proper amount after being decocted with water, then refined through aqueous extraction-alcohol precipitation technology; supernatant is concentrated to creaming of which the relative density is 1.25-1.30 (at 65-70 DEG C); the creaming is added with auxiliary materials to make into granules; or the granules are pressed into tablets; or the granules are made into capsules. The Chinese traditional medicine composition has obvious anti-oxygen deficiency and anti-blood coagulation functions; has functions of increasing blood flow volume in brain and blood flow volume in common carotid artery, lowering cerebral thrombosis thoroughfare caused by blood deficiency in brain; has advantages of convenient storage, carry and administration, low administration dose, no side effect, controllable quality and good stability etc.; and is a sugar-free Chinese traditional medicine composition which can be accepted by a plurality of sufferers who also have diabetes. Therefore, the composition has wide market prospect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of cerebral embolism and its production and use, belong to the field of Chinese medicines.
Background technology
Cerebrovascular is mainly cerebral thrombosis, is one of human three big causes of the death, is characteristics with sickness rate height, mortality rate height, disability rate height, relapse rate height.According to epidemiology statistics in recent years, China's city cerebrovascular sickness rate has reached 120-180/10 ten thousand, and about 1,500,000 examples of annual kainogenesis case are died from cerebrovascular every year and surpassed 1,000,000 people, account for first of the various causes of the death; Disability rate accounts for more than 60% of number of patients; Year relapse rate is 20～30%, harm humans health seriously, and especially the infringement to muscle power attracts people's attention to intelligence, has brought very big burden for society and family, thereby has caused social common concern.
Motherland's medical science thinks that the formation of cerebral thrombosis belongs to " apoplexy " category, in addition, also has argumentations such as " coma ", " sudden falling down ", " emotional syncope " at different times.Generally speaking, its sick position of cerebral thrombosis is at brain, and its cause of disease roughly is trouble nothing more than " wind, fire, expectorant, void, the stasis of blood ".
Make a general survey of the document record, the differentiation of symptoms and signs for classification of syndrome of clinical treatment primary disease roughly can be controlled from following four type opinions.
1, Qi deficiency blood stasis type: many can not transport blood, system blood, cause the blood must not be flourish because of positive QI-insufficiency, the deficiency of vital energy, the blood stasis venation, brain is become homeless foster and thrombosis.Disease is seen hemiplegia, disabled wilted limbs, or single limb need not, facial hemiparalysis, stiff tongue language is puckery, and have dizzy, shortness of breath and palpitation, uncomfortable in chest, face is dark or sallow, limb is soft weak, enlarged tongue and purple, or the ecchymosis point is arranged, stringy and thready pulse is unable or heavy thin and puckery.Control and work as QI invigorating and blood producing, promoting blood circulation to remove obstruction in the collateral, clinical BUYANG HUANWU TANG commonly used is controlled it.If the speech of holding concurrently is unfavorable, add Radix Polygalae, Rhizoma Acori Graminei with the sharp key that eliminates the phlegm; The mouth of holding concurrently is crooked, adds QIANZHENGSAN (Bombyx Batryticatus, Rhizoma Typhonii, Scorpio) to dispel the wind by evil; The upper limb person of attaching undue importance to one thing to the neglect of the other adds Ramulus Mori, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae etc. to dispel the wind by evil; The unable person of lower extremity paralysis adds Radix Achyranthis Bidentatae, Radix Dipsaci, Rhizoma Cibotii, Herba Taxilli with invigorating the kidney and strengthening the bones; As the person that paralyses with the passing of time adds that insect medicine (Scorpio, Scolopendra, Zaocys, Hirudo, Nidus Vespae etc.) picks ailment said due to cold or exposure to search, removing blood stasis with potent drugs is invigorated blood circulation, and its effect is more clear.
2, phlegm and blood stasis, numbness resistance venation type: the expectorant stasis of blood is the core pathogenesis that forms apoplexy, covers fertile people's excessive phlegm, and phlegm-damp is strongly fragrant and give birth to heat, hear rate body fluid, gradually hinders venation.Or spleen deficiency generating phlegm, or water general be expectorant, or contain in the phlegm-fire.The lid stasis of blood is the key of hemiplegia, has blood stasis due to qi deficiency to be subjected to cold coagulation puckery or be heated and decoct into the branch of the stasis of blood, clinically all should examine card and controls.Clinical common hemiplegia, numb limbs and tense tendons, facial hemiparalysis, headache agitation, Light-headedness, cough up phlegm not wellly, tongue is dark red, tongue is greasy in vain, stringy and thready pulse and slide, control and work as eleminating phlegm and freeing channels.The clinical expectorant soup (Arisaema Cum Bile, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Caulis Bambusae In Taenia, the Rhizoma Pinelliae, Fructus Aurantii Immaturus, the Radix Astragali, Rhizoma Acori Graminei, dried tangerine peel, Radix Glycyrrhizae) of washing commonly used.
3, the hepatic and renal YIN deficiency, liver-Yang sthenia type: clinical common hemiplegia, facial hemiparalysis, aphasia, have dizzy, headache, flushed face with red ears, bitter taste in the mouth and dry throat, susceptible to lose temper due to restlessness, dark coloured urine dry stool, pale tongue with thin fur Huang, stringy and thready pulse concurrently.Controlling should suppressing the hyperactive liver and subsiding YANG, calming wind and dredging collateral is a method, the side selects the Zhengan Xifeng Tang plus-minus, as double see irritated insomnia, vertigo and tinnitus, feverish sensation in the palms and soles, the time night sweat is arranged, crimson tongue is red or dark red, few tongue or no fur, thready and stringy pulse or stringy and thready pulse number, control when nourishing YIN and relieve dizziness, high fever, infantile convulsions, epilepsy, etc., side's choosing is also lacked soup (Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Scrophulariae, Radix Ophiopogonis, Fructus Ligustri Lucidi, the Radix Paeoniae Alba, Ramulus Uncariae Cum Uncis, Herba Taxilli, Radix Salviae Miltiorrhizae) and is controlled it, and certain curative effect is arranged.
4, the empty damage of essence of marrow, the hollow type of venation: the lid deficiency of the liver and kindey then marrow Tianjin blood can not on give in brain, the brain department of becoming homeless, then dizzy for a long time vertigo, one's ears rang and spots danced before one's eyes, even amaurosis or lose one's sight; Or emit the limbs contracture mind dusk; Or numb hemiplegia, mouthful not smoothgoing, the soreness of waist and knee of askew language, flushed complexion cold foot, deep red tongue, yellow fur dry mouth, deep pulse are counted accurately etc., control when nourishing YIN and supplementing the kidney, replenishing essence benefit blood.Prescription Bolus as a Kidney-Yin-Tonic plus-minus commonly used.If mind is muddle-headed, when adding Radix Polygalae, Rhizoma Acori Graminei with clearing away phlegm to dredge the orifices; If mental confusion due to phlegm adds cow-bezoar bolus for resurrection and has one's ideas straightened out with clearing away heart-fire and eliminating phlegm; If facial hemiparalysis adds QIANZHENGSAN; If smart void can not on hold and unconsciousness, available dihuang drink plus-minus is with enriching yin and nourishing kidney; If dry mouth is vexed, add Radix Asparagi and Radix Ophiopogonis, Radix Scrophulariae with YIN nourishing and the production of body fluid promoting; If foot and knee flaccidity, when with Huqian Wan with nourishing YIN to lower pathogenic fire, bone and muscle strengthening, treating disease in the upper by managing the lower, kidney tonifying, essence replenishing.
When in case lethargy, stupor, cold extremities hyperhidrosis occurring, and the time order heal up open, stertor with weak breath, limbs are weak and limp, flaccid tongue, faint pulse, this belongs to the depletion syndrome of the traditional Chinese medical science, when anxious clothes shenfu decoction, adds the Radix Astragali, Concha Ostreae, Os Draconis, Fructus Corni, Fructus Schisandrae Chinensis and takes off admittedly with arresting sweating.
The common Chinese patent medicine that is used for the apoplexy syndrome of blood stasis due to qi deficiency has: NAOXUESHUAN PIAN, NAODESHENG, XIAOSHUAN TONGLUO PIAN, Li Naoxin, the peaceful sheet of arteria coronaria, NIAOXUEKANG etc., the main stasis-breaking drug of invigorating blood circulation that uses; NAOLUOTONG JIAONANG is made up of Radix Angelicae Sinensis, Flos Carthami, Sanguis Draxonis, the Radix Polygoni Multiflori, Radix Salviae Miltiorrhizae, the Radix Astragali, methylhesperidin, vitamin B6 etc., though the resistance and supplementing qi medicine Radix Astragali is arranged in the prescription, is not based on QI invigorating, still to invigorate blood circulation." qi being the governor of blood ", " fortune blood person promptly is a gas " (" treatise on blood trouble water fire of moxibustion blood opinion "), " gas is capable to be blood flow " (" element is asked the five internal organs generation " Wang Bing notes).Enrich blood merely and invigorate blood circulation, the blood stasis of blood that heals then, the benefiting QI for activating blood circulation effect of invigorating blood circulation more merely is stronger.In addition the astringency inducing effect of gas makes blood normally follow row among the vascular and do not escape outside arteries and veins.The present invention has QI invigorating, invigorates blood circulation, and relieves dizziness, high fever, infantile convulsions, epilepsy, etc. the effect of collateral dredging.
Summary of the invention
Problem to be solved by this invention provides a kind ofly can effectively treat Chinese medicine composition of cerebral embolism and preparation method thereof.
Technical scheme provided by the invention is that a kind of Chinese medicine composition for the treatment of cerebral embolism is made by the herbal raw material of following weight proportioning: 6～10 parts of Radixs Astragali, 5～7 parts of Rhizoma Chuanxiongs and 3～5 parts of Pheretimas.
The said herbal medicine proportioning raw materials is 8 parts of the Radixs Astragali, 6 parts of Rhizoma Chuanxiongs, 4 parts of Pheretimas.
The dosage form of described Chinese medicine composition is granule, capsule, tablet, oral liquid or syrup etc.
The present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of cerebral embolism: with 6～10 parts of Radixs Astragali, 5～7 parts of Rhizoma Chuanxiongs and 3～5 parts of Pheretimas is that raw material decocts with water, filter, decocting liquid concentrate concentrated solution, adding ethanol in the concentrated solution makes it contain alcohol amount to reach 45～75%, leave standstill 24 hours, getting supernatant concentration, to become relative density be the clear paste of 1.25～1.30 (65 ℃～70 ℃), makes Chinese medicine composition then.
The above-mentioned number of times that decocts with water is 2～3 times, and each amount of water is 10～14 times of raw material weight; Each decocting time 1-1.5 hour; Decoction liquor after at every turn decocting is merged, and reconcentration gets concentrate.
The above-mentioned clear paste that obtains that concentrates, press clear paste: the weight proportion of adjuvant=1: 0.1～3 mixes adjuvant and clear paste, granulates, and drying obtains Chinese medicine composition.
Described adjuvant is at least a or mixture more than two kinds in dextrin or starch, carboxymethyl starch sodium and the magnesium stearate.
The application of Chinese medicine composition of the present invention in the medicine of preparation treatment cerebral embolism.
The pharmacological toxicology of the Chinese medicine composition that the present invention makes and clinical experimental study result show:
1, pharmacological toxicology research
(1) pharmacodynamics: experimental studies results shows that the present invention can obviously increase blood flow in the anesthetized dog brain, cardiac function is shunk in chamber, an anesthetized dog left side do not have obvious influence.The present invention also can significantly increase the Carotid blood flow of anesthetized rat.Can obviously reduce pathological change such as cerebral thrombosis thorough fare and brain water content increase due to the cerebral ischemia, and have tangible prolongation stagnant anoxia mice life span and anti-hypoxia activity.The present invention simultaneously has tangible blood coagulation resisting function.
(2) studies on acute toxicity: mouse stomach of the present invention is with Cmax and maximum volume, promptly irritate stomach 0.2ml at every turn and (be equivalent to dosage 100g/kg by mice body weight 10g, by the crude drug amount), the upper and lower noon respectively is administered once, observe after seven days, the mice activity is ingested, drinking-water, feces, hair color is all no abnormal freely, so none death of mice is LD50＞200g/kg (by the crude drug amount).Be equivalent to 266 times of clinical consumption (0.75g/kg), animal does not see the overt toxicity effect, and the result shows that the disposable medication of the present invention is than safety.
(3) long term toxicity research: 3.125g/kg of the present invention, 6.25g/kg, 12.5g/kg three dosage continuous irrigation stomach SD strain rats 90 days, this moment, basic, normal, high dosage was equivalent to 4,8,16 times of clinical dosage respectively approximately, phase of administration as a result and restorative observation period (2 week) compare with the blank group, the general situation of rat, body weight gain, hematology and blood parameters, main organs coefficient, perusal and the equal no significant difference of mirror undertissue morphological observation or unusual show that it is safe using in the clinical application scope of the present invention.
2, clinical experimental study
(1) II clinical trial phase: treat syndrome of blood stasis due to qi deficiency 100 examples of the convalescent period of apoplexy (Atherosclerosis and thrombosis and cerebral infarction) apoplex involving the channels and collaterals with the present invention, and compare with XIAOSHUAN KELI 103 examples.
The apoplexy curative effect: treatment is organized in 100 examples, clinical recovery 1 example, produce effects 50 examples, effective 41 examples, invalid 8 examples, total effective rate 92.00%, total obvious effective rate 51.00%; In matched group 103 examples, clinical recovery 1 example, produce effects 32 examples, effective 50 examples, invalid 20 examples, total effective rate 80.58%, total obvious effective rate 32.04%.The curative effect of two groups of treatment apoplexies is relatively learned by statistics and is handled, and difference has highly significant meaning (P＜0.01), shows that the present invention obviously is better than matched group to the curative effect of apoplexy.In treatment (14 days) and treatment back (28 days), comparing before two groups of apoplexy integrated values and the treatment all has statistical significance (P＜0.01); Between the group of treatment back statistical significance (P＜0.01) is arranged relatively, between the group of difference statistical significance (P＜0.01) is arranged more also before and after the treatment neutralization treatment back.Show that the present invention and XIAOSHUAN KELI all can treat apoplexy (Atherosclerosis and thrombosis and cerebral infarction), all can obviously reduce the apoplexy integrated value, but curative effect of the present invention is better than XIAOSHUAN KELI.Two groups all can obviously be improved indexs (P＜0.01) such as language performance, upper limb shoulder joint, upper limb articulations digitorum manus, lower limb hip joint, lower limb toe joint and comprehensive function.Compare indexs such as language performance, upper limb articulations digitorum manus and comprehensive function between group and statistical significance (P＜0.05) is arranged, all the other not statistically significants (P＞0.05).Show that the curative effect that the present invention improves indexs such as language performance, upper limb articulations digitorum manus and comprehensive function obviously is better than matched group.
The tcm syndrome curative effect: treatment is organized in 100 examples, clinical recovery 1 example, produce effects 30 examples, effective 59 examples, invalid 10 examples, total effective rate 90.00%, total obvious effective rate 31.00%; In matched group 103 examples, clinical recovery 0 example, produce effects 15 examples, effective 58 examples, invalid 30 examples, total effective rate 70.87%, total obvious effective rate 14.56%.The curative effect of two groups of treatment syndrome of blood stasis due to qi deficiency is relatively learned by statistics and is handled, and difference has highly significant meaning (P＜0.01), shows that the present invention obviously is better than matched group to the curative effect of syndrome of blood stasis due to qi deficiency.After treatment neutralization treatment, comparing before the syndrome of blood stasis due to qi deficiency integrated value of treatment group and matched group and the treatment all has statistical significance (P＜0.01); Treat more equal not statistically significant (P＞0.05) between preceding two groups of groups, between the group of difference statistical significance (P＜0.01) is arranged more all before and after the treatment neutralization treatment back treatment.Two groups all have the upper limb of improvement unsuccessful, and lower limb are unsuccessful, crooked mouth and tongue, the stiff tongue language is stuttering, hemianesthesia, lusterless complexion, spiritlessness and weakness, spontaneous perspiration, cardiopalmus, faint low voice, mouthful sialorrhea, brothers' swelling, dimly pale tongue, there is the petechia ecchymosis on the limit, the effect of indexs such as thready and weak pulse or hesitant pulse (P＜0.01), but imperial stilbene granule (former radix astragali grain) is in that to improve upper limb unsuccessful, lower limb are unsuccessful, hemianesthesia, lusterless complexion, spiritlessness and weakness, symptom aspects such as mouth sialorrhea are better than XIAOSHUAN KELI (P＜0.01, P＜0.05), at crooked mouth and tongue, the stiff tongue language is stuttering, spontaneous perspiration, cardiopalmus, faint low voice, brothers' swelling, dimly pale tongue, there is the petechia ecchymosis on the limit, and both act on quite (P＞0.05) index aspects such as thready and weak pulse or hesitant pulse.
Of the present invention in test group slight abdominal distention 1 example occurs, obvious toxicity do not occur.
(2) III clinical trial phase: treat syndrome of blood stasis due to qi deficiency 313 examples of the convalescent period of apoplexy (Atherosclerosis and thrombosis and cerebral infarction) apoplex involving the channels and collaterals with the present invention, and compare with XIAOSHUAN KELI 126 examples.
The apoplexy curative effect: treatment is organized in 313 examples, clinical recovery 9 examples, produce effects 145 examples, effective 135 examples, invalid 24 examples, total effective rate 92.33%, total obvious effective rate 49.20%; In matched group 125 examples, clinical recovery 0 example, produce effects 41 examples, effective 64 examples, invalid 20 examples, total effective rate 84.00%, total obvious effective rate 32.80%.The curative effect of two groups of treatment apoplexies is relatively learned by statistics and is handled, and difference has highly significant meaning (P＜0.01), shows that the present invention obviously is better than matched group to the curative effect of apoplexy.After treatment neutralization treatment, comparing before two groups of apoplexy integrated values and the treatment all has statistical significance (P＜0.01); Between the group of treatment back statistical significance (P＜0.01) is arranged relatively, between the group of difference statistical significance (P＜0.05, P＜0.01) is arranged more also before and after the treatment neutralization treatment back.Show that the present invention and XIAOSHUAN KELI all can treat apoplexy (Atherosclerosis and thrombosis and cerebral infarction), all can obviously reduce the apoplexy integrated value, but curative effect of the present invention is better than XIAOSHUAN KELI.Two groups all can obviously be improved apoplexy indexs (P＜0.01) such as language performance, upper limb shoulder joint, upper limb articulations digitorum manus, lower limb hip joint, lower limb toe joint and comprehensive function.Relatively statistical significance (P＜0.01 or P＜0.05) is being arranged all aspect language performance, upper limb shoulder joint, upper limb articulations digitorum manus, lower limb toe joint and the comprehensive function between group.Show that the curative effect that the present invention improves each index of apoplexy function of nervous system is better than matched group.
The tcm syndrome curative effect: treatment is organized in 313 examples, clinical recovery 2 examples, produce effects 112 examples, effective 166 examples, invalid 33 examples, total effective rate 89.46%, total obvious effective rate 36.42%; In matched group 125 examples, clinical recovery 0 example, produce effects 31 examples, effective 69 examples, invalid 25 examples, total effective rate 80.00%, total obvious effective rate 24.80%.The curative effect of two groups of treatment syndrome of blood stasis due to qi deficiency is relatively learned by statistics and is handled, and difference has highly significant meaning (P＜0.01), shows that the present invention obviously is better than matched group to the curative effect of syndrome of blood stasis due to qi deficiency.After treatment neutralization treatment, comparing before the syndrome of blood stasis due to qi deficiency integrated value of treatment group and matched group and the treatment all has statistical significance (P＜0.01); Treat more equal not statistically significant (P＞0.05) between preceding two groups of groups, between the group of treatment neutralization treatment back difference statistical significance (P＜0.01) is arranged more all.Show that two groups all have the upper limb of improvement unsuccessful, lower limb are unsuccessful, crooked mouth and tongue, the stiff tongue language is stuttering, hemianesthesia, lusterless complexion, spiritlessness and weakness, spontaneous perspiration, cardiopalmus, faint low voice, the mouth sialorrhea, brothers' swelling, dimly pale tongue, there is the petechia ecchymosis on the limit, the effect of index such as thready and weak pulse or hesitant pulse (P＜0.01), but the present invention is in that to improve upper limb unsuccessful, lower limb are unsuccessful, spiritlessness and weakness, index effect aspects such as faint low voice are better than XIAOSHUAN KELI (P＜0.01, P＜0.05), and crooked mouth and tongue, the stiff tongue language is stuttering, hemianesthesia, lusterless complexion, spontaneous perspiration, cardiopalmus, the mouth sialorrhea, brothers' swelling, dimly pale tongue, limit have the petechia ecchymosis, both act on quite (P＞0.05) index such as thready and weak pulse or hesitant pulse aspect.
Clinical trial shows that the present invention treats the syndrome of blood stasis due to qi deficiency of the convalescent period of apoplexy (Atherosclerosis and thrombosis and cerebral infarction) apoplex involving the channels and collaterals and do not see obvious toxicity.
Chinese medicine composition of the present invention has QI invigorating, invigorates blood circulation, and relieves dizziness, high fever, infantile convulsions, epilepsy, etc. collateral dredging.Be used for the treatment of the convalescent period and the sequela of apoplexy (cerebral thrombosis, cerebral embolism), cerebral arteriosclerosis, hemorrhagic cerebral thrombosis, and have curative effect preferably.The present invention is refined into three flavors through clinical exploration, and is fixed as after the modern formulation, and is reliable through clinical confirmation curative effect again.Flavour of a drug widow of the present invention and component is many, QI invigorating is invigorated blood circulation, and relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and the effect of collateral dredging is stronger.Chinese medicine composition of the present invention (granule, capsule, tablet, oral liquid or syrup etc.) need not decoction, taking convenience, dose are little, has no side effect, and is quality controllable, good stability and be easy to carry and preserve plurality of advantages.
The specific embodiment
Embodiment 1:
Get Radix Astragali 600g, Rhizoma Chuanxiong 700g, Pheretima 500g decocts with water three times, add 12 times of water gagings decocted 1 hour at every turn, collecting decoction, filter, filtrate is concentrated into the 1ml concentrated solution and is equivalent to the 1g crude drug, is cooled to room temperature, adds ethanol and makes and contain alcohol amount to 60%, left standstill 24 hours, getting supernatant concentration to relative density is the clear paste of 1.25～1.30 (65 ℃～70 ℃).
Clear paste mixes with the dextrin of 740g, and is an amount of with 80% ethanol, wet granulation, and drying is made the 1000g granule.
Aluminum-plastic composite membrane bag packing is adopted in packing, every packed 8g, and check, the dress box gets finished product.
Usage and dosage: boiled water is taken after mixing it with water, one time 1 bag, 3 times on the one.
Embodiment 2:
Get Radix Astragali 800g, Rhizoma Chuanxiong 600g, Pheretima 400g decocts with water three times, add 12 times of water gagings decocted 1 hour at every turn, collecting decoction, filter, filtrate is concentrated into the 1ml concentrated solution and is equivalent to the 1g crude drug, is cooled to room temperature, adds ethanol and makes and contain alcohol amount to 60%, left standstill 24 hours, getting supernatant concentration to relative density is the clear paste of 1.25～1.30 (65 ℃～70 ℃).
Clear paste mixes with the dextrin of 720g, and is an amount of with 80% ethanol, wet granulation, and drying is made the 1000g granule.
Aluminum-plastic composite membrane bag packing is adopted in packing, every packed 8g, and check, the dress box gets finished product.
Usage and dosage: boiled water is taken after mixing it with water, one time 1 bag, 3 times on the one.
Embodiment 3:
Get Radix Astragali 1000g, Rhizoma Chuanxiong 500g, Pheretima 300g decocts with water three times, add 12 times of water gagings decocted 1 hour at every turn, collecting decoction, filter, filtrate is concentrated into the 1ml concentrated solution and is equivalent to the 1g crude drug, is cooled to room temperature, adds ethanol and makes and contain alcohol amount to 60%, left standstill 24 hours, getting supernatant concentration to relative density is the clear paste of 1.25～1.30 (65 ℃～70 ℃).
Clear paste mixes with the dextrin of 700g, and is an amount of with 80% ethanol, wet granulation, and drying is made the 1000g granule.Aluminum-plastic composite membrane bag packing is adopted in packing, every packed 8g, and check, the dress box gets finished product.
Usage and dosage: boiled water is taken after mixing it with water, one time 1 bag, 3 times on the one.
Embodiment 4:
Get Radix Astragali 1050g, Rhizoma Chuanxiong 800g, Pheretima 550g decocts with water three times, add 12 times of water gagings decocted 1 hour at every turn, collecting decoction, filter, filtrate is concentrated into the 1ml concentrated solution and is equivalent to the 1g crude drug, is cooled to room temperature, adds ethanol and makes and contain alcohol amount to 60%, left standstill 24 hours, getting supernatant concentration to relative density is the clear paste of 1.25～1.30 (65 ℃～70 ℃).
Clear paste mixes with the carboxymethyl starch sodium of the starch 20g of 30g, granulates with one-step-granulating method, with 24 mesh sieve granulate, is pressed into 1000.
Packing adopts the packaged form of plastic-aluminum bubble-cap to pack, 12 of every plates, and check, the dress box gets finished product.
Usage and dosage: oral, one time 6,3 times on the one.
Embodiment 5:
Get Radix Astragali 1050g, Rhizoma Chuanxiong 800g, Pheretima 550g decocts with water three times, add 12 times of water gagings decocted 1 hour at every turn, collecting decoction, filter, filtrate is concentrated into the 1ml concentrated solution and is equivalent to the 1g crude drug, is cooled to room temperature, adds ethanol and makes and contain alcohol amount to 60%, left standstill 24 hours, getting supernatant concentration to relative density is the clear paste of 1.25～1.30 (65 ℃～70 ℃).
Clear paste mixes with the magnesium stearate of the starch 10g of 40g, granulates with one-step-granulating method, and with 24 mesh sieve granulate, capsule is filled, and polishing is made 1000.
Packing adopts the packaged form of plastic-aluminum bubble-cap to pack, 12 of every plates, and check, the dress box gets finished product.
Usage and dosage: oral, one time 6,3 times on the one.
Embodiment 6:
The clear paste that makes with any method among the embodiment 1-5 is a crude drug, is prepared into oral liquid or syrup according to a conventional method.
Claims (8)
1. Chinese medicine composition for the treatment of cerebral embolism, made by following method: with 6～10 parts of Radixs Astragali of weight proportion, 5～7 parts of Rhizoma Chuanxiongs and 3～5 parts of Pheretimas is that raw material decocts with water, filter, decocting liquid concentrate concentrated solution, adding ethanol in the concentrated solution makes it contain alcohol amount to reach 45～75%, leave standstill 24 hours, getting supernatant concentration, to become 65 ℃～70 ℃ relative density be 1.25～1.30 clear paste, makes Chinese medicine composition then.
2. Chinese medicine composition according to claim 1 is characterized in that: the said herbal medicine proportioning raw materials is 8 parts of the Radixs Astragali, 6 parts of Rhizoma Chuanxiongs, 4 parts of Pheretimas.
3. Chinese medicine composition according to claim 1 and 2 is characterized in that: the dosage form of described Chinese medicine composition is granule, capsule, tablet, oral liquid or syrup.
4. preparation method for the treatment of the Chinese medicine composition of cerebral embolism, it is characterized in that: with 6～10 parts of Radixs Astragali, 5～7 parts of Rhizoma Chuanxiongs and 3～5 parts of Pheretimas is that raw material decocts with water, filter, decocting liquid concentrate concentrated solution, adding ethanol in the concentrated solution makes it contain alcohol amount to reach 45～75%, leave standstill 24 hours, getting supernatant concentration, to become 65 ℃～70 ℃ relative density be 1.25～1.30 clear paste, makes Chinese medicine composition then.
5. preparation method according to claim 4 is characterized in that: the above-mentioned number of times that decocts with water is 2～3 times, and each amount of water is 10～14 times of raw material weight; Each decocting time 1-1.5 hour; Decoction liquor after at every turn decocting is merged, and reconcentration gets concentrate.
6. preparation method according to claim 4 is characterized in that: the above-mentioned clear paste that obtains that concentrates, press clear paste: the weight proportion of adjuvant=1: 0.1～3 mixes clear paste and adjuvant, granulates, and drying obtains Chinese medicine composition.
7. preparation method according to claim 6 is characterized in that: described adjuvant is at least a in dextrin or starch, carboxymethyl starch sodium and the magnesium stearate.
8. claim 1 or the 2 described Chinese medicine compositions application in the medicine of the syndrome of blood stasis due to qi deficiency of the convalescent period of preparation treatment apoplexy apoplex involving the channels and collaterals.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100604778A CN101455712B (en) | 2009-01-09 | 2009-01-09 | Traditional Chinese medicine composition for treating cerebral thrombosis and preparation method and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100604778A CN101455712B (en) | 2009-01-09 | 2009-01-09 | Traditional Chinese medicine composition for treating cerebral thrombosis and preparation method and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101455712A CN101455712A (en) | 2009-06-17 |
| CN101455712B true CN101455712B (en) | 2011-11-30 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106913612A (en) * | 2017-05-15 | 2017-07-04 | 昆明市中医医院 | A kind of pharmaceutical composition for treating Qi deficiency blood stasis type ishemic stroke convalescence and its sequelae and preparation method thereof, preparation and application |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106668767B (en) * | 2016-12-26 | 2018-06-26 | 常锁生 | It is a kind of treat atherosclerosis, hyperlipidemia Chinese medicine |
| CN110433197A (en) * | 2019-08-23 | 2019-11-12 | 湖南省脑科医院 | A kind of stroke in convalescent stage treatment special effect Chinese composition, capsule and preparation method thereof |
| CN111157643A (en) * | 2020-01-02 | 2020-05-15 | 安徽中医药大学 | Traditional Chinese medicine compound research method for treating ischemic cerebrovascular disease based on HPLC technology |
| CN111840461B (en) * | 2020-09-15 | 2024-01-30 | 瑞阳制药股份有限公司 | Chinese herbal compound preparation for preventing and treating stroke as well as preparation method and application thereof |
| CN114869956B (en) * | 2022-02-11 | 2023-09-22 | 福建中医药大学附属人民医院（福建省人民医院） | Pharmaceutical composition for treating post-stroke dyskinesia, and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1676141A (en) * | 2004-04-02 | 2005-10-05 | 郭秀华 | Enteric coated capsule for treating iron-deficiency apoplexia and its preparing process |
| CN1726955A (en) * | 2005-07-29 | 2006-02-01 | 北京蓝贝望医药科技开发有限公司 | Compound soft capsule of earthworm and preparation method |
| CN1943621A (en) * | 2005-10-08 | 2007-04-11 | 周小明 | Chinese medicine composition for treating apoplexy and its preparing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1676141A (en) * | 2004-04-02 | 2005-10-05 | 郭秀华 | Enteric coated capsule for treating iron-deficiency apoplexia and its preparing process |
| CN1726955A (en) * | 2005-07-29 | 2006-02-01 | 北京蓝贝望医药科技开发有限公司 | Compound soft capsule of earthworm and preparation method |
| CN1943621A (en) * | 2005-10-08 | 2007-04-11 | 周小明 | Chinese medicine composition for treating apoplexy and its preparing method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106913612A (en) * | 2017-05-15 | 2017-07-04 | 昆明市中医医院 | A kind of pharmaceutical composition for treating Qi deficiency blood stasis type ishemic stroke convalescence and its sequelae and preparation method thereof, preparation and application |
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