CN102228544A - Traditional Chinese medicine composition for treating leucoderma and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating leucoderma and preparation method thereof Download PDFInfo
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- CN102228544A CN102228544A CN2011101927069A CN201110192706A CN102228544A CN 102228544 A CN102228544 A CN 102228544A CN 2011101927069 A CN2011101927069 A CN 2011101927069A CN 201110192706 A CN201110192706 A CN 201110192706A CN 102228544 A CN102228544 A CN 102228544A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating leucoderma. The composition comprises, by weight, 10 to 40 parts of Vernonia anthelmintica, 10 to 40 parts of fructus psoraleae, 5 to 20 parts of Plumbago zeylanica, 5 to 30 parts of Operculina turpethum, 10 to 40 parts of Chinese angelica, 5 to 20 parts of madder, and 10 to 20 parts of Radix Codonopsis. The invention also discloses a preparation method of the composition. According to the present invention, Vernonia anthelmintica and fructus psoraleae which are treated as main raw materials allow the activity of tyrosinase in vivo to be activated and formation of melanocyte on skin lesions to be promoted, so the composition with other medicinal components has the advantages of activating and cooling blood, expelling wind and clearing away cold, eliminating and absorbing stases, and killing insects and curing tinea, thereby pathogenic reasons of leucoderma can be fundamentally solved, focus can be directly removed, and a purpose of fundamental solution is reached.
Description
Technical field
The present invention relates to the leukodermic medicine of a kind of treatment, be specifically related to a kind of compositions of forming by Chinese medicine ingredients, belong to medical technical field.
Background technology
Vitiligo is a kind of commonly encountered diseases, frequently-occurring disease.Primary disease all has generation all over the world, can involve all races.According to statistics, leukodermic whole world prevalence is 0.5%～4%, and different countries and regions and different ethnic prevalence be difference to some extent.Crowd's prevalence that general colour is shallow is lower, and the darker crowd's prevalence of the colour of skin is then higher.According to the literature, the white American's prevalence is about 1%, and Britain is 0.4%, and Russia is 0.45%, and Japan is 2%, and the crowd's prevalence on the island of Denmark is 0.38%, in South India then up to 4%.Other has investigation to find, in some village of India, the vitiligo prevalence is especially up to 8%, and this may be because due to the leukodermic heritability, promptly because consanguineous marriage causes the probability of heredity to increase.In China, since populous, the region difference, and crowd's prevalence report differs.According to the sick investigation report of Shanghai City 110,000 application on human skin, vitiligo accounts for 0.54% of number; 86536 people were investigated in 1987 in the area, Nanjing, and prevalence is 0.29%; 461433 people were investigated in Jinan, Shandong in 1977, and prevalence is 2.7%; The prevalence of northern Suzhou rural survey is 0.15%.Estimate that according to hygiene department China's vitiligo number of patients is greatly about about 3,000 ten thousand.Aspect sex, it is generally acknowledged, the both sexes prevalence about equally, and no significant difference.On age of onset, vitiligo can betide any age level, but is many with the youth.95% patient on the books fell ill before 40 years old, wherein sent out the patient in 11～30 years old and accounted for more than 60% of patient's sum.Have data to show abroad, children vitiligo is also not rare, and the mean age of its morbidity is 4.6～8 years old, and is different with the adult, and children vitiligo has than significant sex difference, and it is many that girl falls ill.
The leukodermic medicine of a lot of treatments is arranged now, and existing Chinese medicine also has Western medicine, though can both play a role, can not effect a radical cure, and recurrence easily, drug dependence is strong.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention provides the leukodermic Chinese medicine composition of a kind of treatment, this Chinese medicine composition has the advantage that stability is high, therapeutic effect is good.
The present invention also provides the preparation method of this Chinese medicine composition.
The present invention is achieved by the following technical solutions:
The leukodermic Chinese medicine composition of a kind of treatment is characterized in that effective ingredient comprises following materials of weight proportions:
10～40 parts of Caulis Vernoniae andersoniis, 10～40 parts of Fructus Psoraleaes, 5～20 parts of Radix Plumbaginis Zeylanicaes, 5～30 parts in rattan of box fruit, 10～40 parts of Radix Angelicae Sinensis, 5～20 parts in Radix Rubiae, 10～20 parts of Radix Codonopsis.
The preferred feedstock prescription of said medicine is (weight portion): 24 parts of Caulis Vernoniae andersoniis, 24 parts of Fructus Psoraleaes, 8 parts of Radix Plumbaginis Zeylanicaes, 12 parts in rattan of box fruit, 24 parts of Radix Angelicae Sinensis, 10 parts in Radix Rubiae, 15 parts of Radix Codonopsis.
Main prescription of the present invention is Caulis Vernoniae andersonii, Fructus Psoraleae, Radix Plumbaginis Zeylanicae, box fruit rattan, Radix Angelicae Sinensis, Radix Rubiae and Radix Codonopsis.Caulis Vernoniae andersonii is a kind of leukoderma to be had the plant of magical curative effect, and it only is grown in the minority area of southern Xinjiang of high height above sea level and Pakistan, India.Effect with clearing heat for detumescence, parasite killing treatment tinea.Fructus Psoraleae another name bone fat, Fructus Psoraleae, so fat, so son, so it, Semen Oroxyli, bosom Fructus Psoraleae, broken event fat, Fructus Psoraleae, Fructus Psoraleae, broken frame, the solid fat of mother-in-law is mended the bone sparrow hawk, FRUCTUS PSORALEAE, black Semen Oroxyli, Hu Fructus Psoraleae, Hu Semen Allii Tuberosi, Ji Guzi, with blue Herba Amaranthi tricoloris, Gu son, Gu fat, the river Fructus Psoraleae, lucky Fructus Psoraleae, broken solid fat, Semen Allii Tuberosi has warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal effect recklessly.Radix Plumbaginis Zeylanicae another name hillside Siberian cocklebur, false jasmine are herb and the root of dicotyledon medicine Plumbaginaceae plant Radix Plumbaginis Zeylanicae, have dispel the wind, dissipating blood stasis, detoxifcation, parasiticidal effect, can control the toxic swelling malignant boil, scabies.Box fruit rattan, another name SONGJINTENG, Radix Ipomoeae rattan, soft muscle rattan, Radix Operculine trupethi.Produce ground such as honest and just horse, Jinghong, be born in the regional river bank of low height above sea level (about 520 meters) Pingba dryly or near the village.China Guangdong, western part, Guangxi, Taiwan also have.Be distributed in tropical East Africa, Mascarene Islands, plug tongue ear archipelago, Tropical Asia is imported large and small Antilles Islands to tropical Oceania and Polynesia.Radix Angelicae Sinensis is a tonic, and having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, and the effect of loosening bowel to relieve constipation can be treated injury from falling down, ulcer sores.Radix Rubiae other Ming Qian grass, Herba Chenopodii Hybridi, Abacopteris penangiana (Hook.) Ching, HUOXUEDAN, Salvia kiaometiensis Levl.f.pubescens Stib., red internal diabetes etc., dry root and rhizome for Maguireothamnus speciosus Radix Rubiae Rubia cordifolia L. has the effect of cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling, share with Radix Codonopsis have cooling blood for hemostasis, the strong effect of strengthening the spleen gas.
The leukodermic mechanism of action of combination treatment of the present invention is realized by multipath, the effect of many target spots.Mainly show following several respects 1, activity of tyrosinase: Caulis Vernoniae andersonii has activation to tryrosinase, improves skin to ultraviolet sensitivity, and tyrosinase activity and melanocyte growing amount all are the dose dependent activation.Fructus Psoraleae is a heliosensitivity Chinese medicine, and the psoralen that includes has tangible activation by improving the activity of tryrosinase to tryrosinase, promotes the black funicular cell (Mc) at skin lesion place to form, and speed and quantity that melanin is generated increase.2, direct local trace element supplement: medicines such as Caulis Vernoniae andersonii are rich in the human body various trace elements, and are as copper, zinc, ferrum, manganese, cobalt, selenium etc., wherein the closest with copper, zinc and leukodermic relation.Copper ion is the activator of tryrosinase, contains the zinc of high concentration in the melanin granule, lacks trace element such as copper, zinc, ferrum, manganese and can make tyrosinase activity reduce the melanocyte biosynthesis block.Can direct local trace element supplement, thus can effectively activate tryrosinase, promote melanocyte synthetic.3, improve the local microcirculation obstacle, drive Bai Babu phase capsule have promote blood circulation, the effect for the treatment of blood disorders, can improve the microcirculation of lesions position skin, correct qi depression to blood stasis, blockage of meridian and failure of skin and muscle to be nourished state, thereby promote melanocyte synthetic.4, strengthen humoral immunization: Caulis Vernoniae andersonii has the enhancing humoral immune function, can make the A at the people
375The specific antibody activity of black rope oncocyte proteantigen is suppressed.Fructus Psoraleae can improve the growing multiplication speed of diploid cell significantly, and pair cell has anti-aging effects, improves huge cytophilic phagocytic function, improves the ability of body nonspecific immunity.5, Radix Plumbaginis Zeylanicae, box fruit rattan, Radix Angelicae Sinensis, Radix Rubiae and Radix Codonopsis cooling blood for hemostasis, promoting blood circulation to remove blood stasis, expelling wind and cold, parasite killing are treated tinea, cooperate synergism, performance curative effect with Caulis Vernoniae andersonii, Fructus Psoraleae.
Except above primary raw material medicine, can also add some auxiliary elements in the prescription of the present invention increases curative effects, forms a series of son side, concrete comprises following son side:
Can add an amount of Rhizoma Alpiniae Officinarum on the basis of original prescription, Rhizoma Alpiniae Officinarum another name wind Rhizoma Zingiberis Recens, little Rhizoma Alpiniae Officinarum, high Rhizoma Zingiberis Recens, Rhizoma Alpiniae Officinarum, rough Rhizoma Zingiberis Recens, Fructus Citri Sarcodactylis root, current chart Rhizoma Zingiberis Recens are the dry rhizome of zingiberaceous plant Alpinia officinarum Hance.Add Rhizoma Alpiniae Officinarum can increase dispel the wind, the cold expelling effect, improve effect.Consumption is Rhizoma Alpiniae Officinarum 5～20 weight portions.
On the basis of original prescription, can add the Cortex Moutan composition, by with the coordinated of original formulation of drug, increase clearing away heat and cooling blood, function of promoting blood circulation to disperse blood clots.The Cortex Moutan consumption is 5～30 weight portions.
On the basis of original prescription, can add Rhizoma Chuanxiong, Fructus Ligustri Lucidi and Fructus Tribuli composition.Fructus Tribuli is the fruit of zygophyllaceae plant Fructus Tribuli, another name thatch (" Book of Songs "), Fructus Tribuli (" Mao Shichuan "), Fructus Tribuli, bypass, the drawer people, end row, the jackal plumage, rise and push away (" herbal classic "), it is Herba chenopodii (" not Lu "), Fructus Atriplicis Sibiricae (" property of medicine opinion "), Du Fructus Tribuli (Holy Benevolent Prescriptions), stop plumage (" detailed outline "), drought grass (" book on Chinese herbal medicine is through separating "), triangle Fructus Tribuli (" book on Chinese herbal medicine is looked for the truth "), three JIAOCI (" middle traditional Chinese medicines are planted will "), anistree thorn (" Qinghai medical material "), the puncture frame, wild Pedicellus et Pericarpium Trapae, ground Pedicellus et Pericarpium Trapae (" medicine will is planted in Jiangsu "), hard Fructus Tribuli Ji Li Follicle radish (" Shandong Chinese medicine ").By with the coordinated of original formulation of drug, can increase blood circulation promoting and blood stasis dispelling, liver and kidney tonifying, the effect of suppressing the hyperactive liver resolving depression.Consumption is: Rhizoma Chuanxiong 5～10 weight portions, Fructus Ligustri Lucidi 10～15 weight portions, Fructus Tribuli 5～10 weight portions.
On the basis of original prescription, can also add Semen Cuscutae, Radix Rehmanniae composition, increase liver and kidney tonifying, removing heat from blood blood tonification effect.Consumption is: Semen Cuscutae 5～15 weight portions, Radix Rehmanniae 10～20 weight portions.
On the basis of original prescription, can also add Caulis Spatholobi, Radix Arnebiae (Radix Lithospermi) composition, increase invigorate blood circulation, nourish blood, Detoxication.Consumption is: Caulis Spatholobi 1～15 weight portion, Radix Arnebiae (Radix Lithospermi) 10～20 weight portions.
On the basis of original prescription, can also add the Radix Angelicae Dahuricae, Concha Ostreae composition, increase expelling wind and removing dampness, trace element supplement effect.Consumption is: the Radix Angelicae Dahuricae 10～30 weight portions, Concha Ostreae 5～20 weight portions.
The above-mentioned a plurality of sub-Fang Junneng that derive out on the basis of original prescription play the leukodermic effect of treatment, and therapeutic effect is increasing in varying degrees.The auxiliary element that adds in above-mentioned each son side can mix stack mutually to be used, and forms new son side.For example, on the basis of original prescription, can add Rhizoma Alpiniae Officinarum, Rhizoma Chuanxiong, Fructus Ligustri Lucidi, Fructus Tribuli composition simultaneously, form new son side.Also can on the basis of original prescription, add Caulis Spatholobi, Radix Arnebiae (Radix Lithospermi), the Radix Angelicae Dahuricae, Concha Ostreae composition simultaneously, form new son side.Other auxiliary elements also can be used with.
Chinese medicine composition of the present invention can be made into capsule, also can add corresponding adjuvant and make tablet, pill, granule.The only used adjuvant difference of preparation different dosage form, effective ingredient still are the same, and therapeutic effect is also identical or approximate.The adjuvant of tablet is starch, microcrystalline Cellulose, pregelatinized Starch, lactose, carboxymethylstach sodium, hypromellose, Pulvis Talci, magnesium stearate etc., the adjuvant of pill is starch, microcrystalline Cellulose, carboxymethylstach sodium, hypromellose etc., the adjuvant of granule is a multitudinous Icing Sugar etc., and the adjuvant of capsule is starch, pregelatinized Starch, carboxymethylstach sodium, hypromellose, magnesium stearate etc.; The consumption of adjuvant adds according to existing pharmaceutic adjuvant consumption or adjusts slightly.
The using method of medicine of the present invention is: oral, a 3-5 grain is a course of treatment all around, and take effect general 2-3 course of treatment.
Its preparation method comprises the following steps:
(1) Caulis Vernoniae andersonii is ground into fine powder, standby;
(2) remaining crude drug is mixed, with the ethanol extraction of 6～12 quality times 2 times, merge extractive liquid;
(3) extracting solution is condensed into thick paste, adds the fine powder of step (1) then in thick paste, the mix homogeneously after drying gets dry extract;
(4) dried cream powder is broken into fine powder, adds the adjuvant of survival dose, make the medicine of required dosage form.
In the above-mentioned steps (2), used alcoholic acid volume fraction is 50～80%, during extracted twice, and for the first time 2h, 1h for the second time.
In the above-mentioned steps (3), the relative density of described thick paste under 50 ℃ is 1.10～1.40.
The present invention is based on Caulis Vernoniae andersonii, Fructus Psoraleae, swash the in vivo activity of tryrosinase, promote the black funicular cell (Mc) at skin lesion place to form, be aided with the other drug composition, promoting blood circulation and cooling blood, expelling wind and cold, dissipating blood stasis blood stasis dispelling, parasite killing are treated tinea, fundamentally solve the vitiligo pathogenic factor, directly remove focus, reach the purpose of radical cure.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment, should be understood that, following explanation only is in order to explain the present invention, its content not to be limited.Following composition is if no specified otherwise is weight portion.
Embodiment 1
Medicine of the present invention, preparation method comprises:
(1) gets 24 parts of Caulis Vernoniae andersoniis, 24 parts of Fructus Psoraleaes, 8 parts of Radix Plumbaginis Zeylanicaes, 12 parts in rattan of box fruit, 24 parts of Radix Angelicae Sinensis, 10 parts in Radix Rubiae, 15 parts of Radix Codonopsis;
(2) Caulis Vernoniae andersonii is ground into fine powder, standby;
(3) all the other medical materials are measured 65% ethanol extractions 2 times with 10 times, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and filtrate is concentrated into the thick paste that relative density is 1.25～1.30 (50 ℃);
(4) with medical material fine powder and above-mentioned thick paste mixing, drying;
(5) be ground into fine powder, add an amount of pharmaceutic adjuvant, mixing is granulated, and drying is encapsulated, promptly.
Embodiment 2
Medicine of the present invention, prescription is: 24 parts of Caulis Vernoniae andersoniis, 24 parts of Fructus Psoraleaes, 8 parts of Radix Plumbaginis Zeylanicaes, 12 parts in rattan of box fruit, 24 parts of Radix Angelicae Sinensis, 10 parts in Radix Rubiae, 15 parts of Radix Codonopsis, 12 parts of Rhizoma Alpiniae Officinarums, preparation method is with embodiment 1, different is to add additive of tablet medicine is made tablet, and used adjuvant and consumption are prior art.
Embodiment 3
Medicine of the present invention, prescription is: 24 parts of Caulis Vernoniae andersoniis, 24 parts of Fructus Psoraleaes, 8 parts of Radix Plumbaginis Zeylanicaes, 12 parts in rattan of box fruit, 24 parts of Radix Angelicae Sinensis, 10 parts in Radix Rubiae, 15 parts of Radix Codonopsis, 15 parts of Cortex Moutans, preparation method is with embodiment 1, different is to add the pill adjuvant medicine is made pill, and used adjuvant and consumption are prior art.
Embodiment 4
Medicine of the present invention, filling a prescription is: 24 parts of Caulis Vernoniae andersoniis, 24 parts of Fructus Psoraleaes, 8 parts of Radix Plumbaginis Zeylanicaes, 12 parts in rattan of box fruit, 24 parts of Radix Angelicae Sinensis, 10 parts in Radix Rubiae, 15 parts of Radix Codonopsis, 10 parts of Rhizoma Chuanxiongs, 15 parts of Fructus Ligustri Lucidi, 10 parts of Fructus Tribulis, preparation method is with embodiment 1.
Embodiment 5
Medicine of the present invention, filling a prescription is: 24 parts of Caulis Vernoniae andersoniis, 24 parts of Fructus Psoraleaes, 8 parts of Radix Plumbaginis Zeylanicaes, 12 parts in rattan of box fruit, 24 parts of Radix Angelicae Sinensis, 10 parts in Radix Rubiae, 15 parts of Radix Codonopsis, 10 parts of Semen Cuscutae, 15 parts of Radix Rehmanniae, preparation method is with embodiment 1.
Embodiment 6
Medicine of the present invention, filling a prescription is: 24 parts of Caulis Vernoniae andersoniis, 24 parts of Fructus Psoraleaes, 8 parts of Radix Plumbaginis Zeylanicaes, 12 parts in rattan of box fruit, 24 parts of Radix Angelicae Sinensis, 10 parts in Radix Rubiae, 15 parts of Radix Codonopsis, 12 parts of Caulis Spatholobis, 15 parts of Radix Arnebiae (Radix Lithospermi)s, preparation method is with embodiment 1.
Embodiment 7
Medicine of the present invention, filling a prescription is: 24 parts of Caulis Vernoniae andersoniis, 24 parts of Fructus Psoraleaes, 8 parts of Radix Plumbaginis Zeylanicaes, 12 parts in rattan of box fruit, 24 parts of Radix Angelicae Sinensis, 10 parts in Radix Rubiae, 15 parts of Radix Codonopsis, 20 parts of the Radixs Angelicae Dahuricae, 10 parts of Concha Ostreaes, preparation method is with embodiment 1.
Embodiment 8
Medicine of the present invention, prescription is: 24 parts of Caulis Vernoniae andersoniis, 24 parts of Fructus Psoraleaes, 8 parts of Radix Plumbaginis Zeylanicaes, 12 parts in rattan of box fruit, 24 parts of Radix Angelicae Sinensis, 10 parts in Radix Rubiae, 15 parts of Radix Codonopsis, 12 parts of Rhizoma Alpiniae Officinarums, 15 parts of Cortex Moutans, 10 parts of Rhizoma Chuanxiongs, 15 parts of Fructus Ligustri Lucidi, 10 parts of Fructus Tribulis, 10 parts of Semen Cuscutae, 15 parts of Radix Rehmanniae, 12 parts of Caulis Spatholobis, 15 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts of the Radixs Angelicae Dahuricae, 10 parts of Concha Ostreaes, preparation method is with embodiment 1.
Embodiment 9
Medicine of the present invention is prepared by following method:
(1) gets 10 parts of Caulis Vernoniae andersoniis, 10 parts of Fructus Psoraleaes, 20 parts of Radix Plumbaginis Zeylanicaes, 30 parts in rattan of box fruit, 10 parts of Radix Angelicae Sinensis, 20 parts in Radix Rubiae, 10 parts of Radix Codonopsis;
(2) Caulis Vernoniae andersonii is ground into fine powder, standby;
(3) all the other medical materials are measured the 80vol% ethanol extractions 2 times with 6 times, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and filtrate is concentrated into the thick paste that relative density is 1.10～1.25 (50 ℃);
(4) with medical material fine powder and above-mentioned thick paste mixing, drying;
(5) be ground into fine powder, add an amount of pharmaceutic adjuvant, make granule.
Embodiment 10
Medicine of the present invention is prepared by following method:
(1) gets 40 parts of Caulis Vernoniae andersoniis, 40 parts of Fructus Psoraleaes, 5 parts of Radix Plumbaginis Zeylanicaes, 5 parts in rattan of box fruit, 15 parts of Radix Angelicae Sinensis, 5 parts in Radix Rubiae, 20 parts of Radix Codonopsis;
(2) Caulis Vernoniae andersonii is ground into fine powder, standby;
(3) all the other medical materials are measured the 50vol% ethanol extractions 2 times with 12 times, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and filtrate is concentrated into the thick paste that relative density is 1.25～1.40 (50 ℃);
(4) with medical material fine powder and above-mentioned thick paste mixing, drying;
(5) be ground into fine powder, add an amount of pharmaceutic adjuvant, make tablet.
Embodiment 11
Medicine of the present invention, filling a prescription is: 30 parts of Caulis Vernoniae andersoniis, 25 parts of Fructus Psoraleaes, 10 parts of Radix Plumbaginis Zeylanicaes, 20 parts in rattan of box fruit, 40 parts of Radix Angelicae Sinensis, 8 parts in Radix Rubiae, 18 parts of Radix Codonopsis, preparation method is with embodiment 1.
Embodiment 12
Medicine of the present invention, filling a prescription is: 10 parts of Caulis Vernoniae andersoniis, 40 parts of Fructus Psoraleaes, 20 parts of Radix Plumbaginis Zeylanicaes, 5 parts in rattan of box fruit, 40 parts of Radix Angelicae Sinensis, 5 parts in Radix Rubiae, 20 parts of Radix Codonopsis, 20 parts of Rhizoma Alpiniae Officinarums, preparation method is with embodiment 3.
Embodiment 13
Medicine of the present invention, filling a prescription is: 40 parts of Caulis Vernoniae andersoniis, 10 parts of Fructus Psoraleaes, 5 parts of Radix Plumbaginis Zeylanicaes, 30 parts in rattan of box fruit, 10 parts of Radix Angelicae Sinensis, 20 parts in Radix Rubiae, 10 parts of Radix Codonopsis, 5 parts of Rhizoma Alpiniae Officinarums, preparation method is with embodiment 10.
Embodiment 14
Medicine of the present invention, filling a prescription is: 10 parts of Caulis Vernoniae andersoniis, 40 parts of Fructus Psoraleaes, 20 parts of Radix Plumbaginis Zeylanicaes, 5 parts in rattan of box fruit, 40 parts of Radix Angelicae Sinensis, 5 parts in Radix Rubiae, 20 parts of Radix Codonopsis, 5 parts of Cortex Moutans, preparation method is with embodiment 9.
Embodiment 15
Medicine of the present invention, filling a prescription is: 40 parts of Caulis Vernoniae andersoniis, 10 parts of Fructus Psoraleaes, 5 parts of Radix Plumbaginis Zeylanicaes, 30 parts in rattan of box fruit, 10 parts of Radix Angelicae Sinensis, 20 parts in Radix Rubiae, 10 parts of Radix Codonopsis, 30 parts of Cortex Moutans, preparation method is with embodiment 3.
Embodiment 16
Medicine of the present invention, filling a prescription is: 10 parts of Caulis Vernoniae andersoniis, 40 parts of Fructus Psoraleaes, 20 parts of Radix Plumbaginis Zeylanicaes, 5 parts in rattan of box fruit, 40 parts of Radix Angelicae Sinensis, 5 parts in Radix Rubiae, 20 parts of Radix Codonopsis, 8 parts of Rhizoma Chuanxiongs, 12 parts of Fructus Ligustri Lucidi, 5 parts of Fructus Tribulis, preparation method is with embodiment 9.
Embodiment 17
Medicine of the present invention, filling a prescription is: 40 parts of Caulis Vernoniae andersoniis, 10 parts of Fructus Psoraleaes, 5 parts of Radix Plumbaginis Zeylanicaes, 30 parts in rattan of box fruit, 10 parts of Radix Angelicae Sinensis, 20 parts in Radix Rubiae, 10 parts of Radix Codonopsis, 5 parts of Rhizoma Chuanxiongs, 10 parts of Fructus Ligustri Lucidi, 8 parts of Fructus Tribulis, preparation method is with embodiment 3.
Embodiment 18
The Bai Babu phase capsule that drives of the present invention, filling a prescription is: 40 parts of Caulis Vernoniae andersoniis, 10 parts of Fructus Psoraleaes, 5 parts of Radix Plumbaginis Zeylanicaes, 30 parts in rattan of box fruit, 10 parts of Radix Angelicae Sinensis, 20 parts in Radix Rubiae, 10 parts of Radix Codonopsis, 5 parts of Semen Cuscutae, 20 parts of Radix Rehmanniae, preparation method is with embodiment 10.
Embodiment 19
Medicine of the present invention, filling a prescription is: 10 parts of Caulis Vernoniae andersoniis, 40 parts of Fructus Psoraleaes, 20 parts of Radix Plumbaginis Zeylanicaes, 5 parts in rattan of box fruit, 40 parts of Radix Angelicae Sinensis, 5 parts in Radix Rubiae, 20 parts of Radix Codonopsis, 15 parts of Semen Cuscutae, 10 parts of Radix Rehmanniae, preparation method is with embodiment 9.
Embodiment 20
Medicine of the present invention, filling a prescription is: 40 parts of Caulis Vernoniae andersoniis, 10 parts of Fructus Psoraleaes, 5 parts of Radix Plumbaginis Zeylanicaes, 30 parts in rattan of box fruit, 10 parts of Radix Angelicae Sinensis, 20 parts in Radix Rubiae, 10 parts of Radix Codonopsis, 1 part of Caulis Spatholobi, 20 parts of Radix Arnebiae (Radix Lithospermi)s, preparation method is with embodiment 10.
Embodiment 21
Medicine of the present invention, filling a prescription is: 10 parts of Caulis Vernoniae andersoniis, 40 parts of Fructus Psoraleaes, 20 parts of Radix Plumbaginis Zeylanicaes, 5 parts in rattan of box fruit, 40 parts of Radix Angelicae Sinensis, 5 parts in Radix Rubiae, 20 parts of Radix Codonopsis, 15 parts of Caulis Spatholobis, 10 parts of preparation methoies of Radix Arnebiae (Radix Lithospermi) are with embodiment 3.
Embodiment 22
Medicine of the present invention, filling a prescription is: 40 parts of Caulis Vernoniae andersoniis, 10 parts of Fructus Psoraleaes, 5 parts of Radix Plumbaginis Zeylanicaes, 30 parts in rattan of box fruit, 10 parts of Radix Angelicae Sinensis, 20 parts in Radix Rubiae, 10 parts of Radix Codonopsis, 10 parts of the Radixs Angelicae Dahuricae, 20 parts of Concha Ostreaes, preparation method is with embodiment 10.
Embodiment 23
Medicine of the present invention, filling a prescription is: 10 parts of Caulis Vernoniae andersoniis, 40 parts of Fructus Psoraleaes, 20 parts of Radix Plumbaginis Zeylanicaes, 5 parts in rattan of box fruit, 40 parts of Radix Angelicae Sinensis, 5 parts in Radix Rubiae, 20 parts of Radix Codonopsis, 30 parts of the Radixs Angelicae Dahuricae, 5 parts of preparation methoies of Concha Ostreae are with embodiment 9.
Embodiment 24
Medicine of the present invention, prescription is: 24 parts of Caulis Vernoniae andersoniis, 24 parts of Fructus Psoraleaes, 8 parts of Radix Plumbaginis Zeylanicaes, 12 parts in rattan of box fruit, 24 parts of Radix Angelicae Sinensis, 10 parts in Radix Rubiae, Radix Codonopsis 15 10 parts of Fen, Semen Cuscutae, 15 parts of Radix Rehmanniae, 20 parts of the Radixs Angelicae Dahuricae, 10 parts of Concha Ostreaes, preparation method is with embodiment 1.
Embodiment 25
Medicine of the present invention, prescription is: 40 parts of Caulis Vernoniae andersoniis, 10 parts of Fructus Psoraleaes, 5 parts of Radix Plumbaginis Zeylanicaes, 30 parts in rattan of box fruit, 10 parts of Radix Angelicae Sinensis, 20 parts in Radix Rubiae, Radix Codonopsis 10 5 parts of Fen, Semen Cuscutae, 20 parts of Radix Rehmanniae, 30 parts of the Radixs Angelicae Dahuricae, 5 parts of Concha Ostreaes, preparation method is with embodiment 3.
Embodiment 26
Medicine of the present invention, prescription is: 10 parts of Caulis Vernoniae andersoniis, 40 parts of Fructus Psoraleaes, 20 parts of Radix Plumbaginis Zeylanicaes, 5 parts in rattan of box fruit, 40 parts of Radix Angelicae Sinensis, 5 parts in Radix Rubiae, Radix Codonopsis 20 15 parts of Fen, Semen Cuscutae, 10 parts of Radix Rehmanniae, 30 parts of the Radixs Angelicae Dahuricae, 5 parts of Concha Ostreaes, preparation method is with embodiment 9.
Embodiment 27
Medicine of the present invention, prescription is: 24 parts of Caulis Vernoniae andersoniis, 24 parts of Fructus Psoraleaes, 8 parts of Radix Plumbaginis Zeylanicaes, 12 parts in rattan of box fruit, 24 parts of Radix Angelicae Sinensis, 10 parts in Radix Rubiae, 15 parts of Radix Codonopsis, 10 parts of Rhizoma Chuanxiongs, 15 parts of Fructus Ligustri Lucidi, 10 parts of Fructus Tribulis, 12 parts of Caulis Spatholobis, 15 parts of Radix Arnebiae (Radix Lithospermi)s, preparation method is with embodiment 1.
Embodiment 28
Medicine of the present invention, prescription is: 10 parts of Caulis Vernoniae andersoniis, 40 parts of Fructus Psoraleaes, 20 parts of Radix Plumbaginis Zeylanicaes, 5 parts in rattan of box fruit, 40 parts of Radix Angelicae Sinensis, 5 parts in Radix Rubiae, 20 parts of Radix Codonopsis, 8 parts of Rhizoma Chuanxiongs, 12 parts of Fructus Ligustri Lucidi, 5 parts of Fructus Tribulis, 1 part of Caulis Spatholobi, 20 parts of Radix Arnebiae (Radix Lithospermi)s, preparation method is with embodiment 3.
Embodiment 29
Medicine of the present invention, prescription is: 40 parts of Caulis Vernoniae andersoniis, 10 parts of Fructus Psoraleaes, 5 parts of Radix Plumbaginis Zeylanicaes, 30 parts in rattan of box fruit, 10 parts of Radix Angelicae Sinensis, 20 parts in Radix Rubiae, 10 parts of Radix Codonopsis, 5 parts of Rhizoma Chuanxiongs, 10 parts of Fructus Ligustri Lucidi, 8 parts of Fructus Tribulis, 15 parts of Caulis Spatholobis, 10 parts of Radix Arnebiae (Radix Lithospermi)s, preparation method is with embodiment 10.
Embodiment 30
Medicine of the present invention, prescription is: 40 parts of Caulis Vernoniae andersoniis, 10 parts of Fructus Psoraleaes, 5 parts of Radix Plumbaginis Zeylanicaes, 30 parts in rattan of box fruit, 10 parts of Radix Angelicae Sinensis, 20 parts in Radix Rubiae, 10 parts of Radix Codonopsis, 12 parts of Rhizoma Alpiniae Officinarums, 15 parts of Cortex Moutans, 20 parts of the Radixs Angelicae Dahuricae, 10 parts of Concha Ostreaes, preparation method is with embodiment 10.
Except that combinations thereof, the auxiliary element that adds in any son side can be used with other auxiliary elements, with the Cortex Moutan is example, they can with the Rhizoma Alpiniae Officinarum that adds in other son sides, Rhizoma Chuanxiong, Fructus Ligustri Lucidi, Fructus Tribuli combination Semen Cuscutae, Radix Rehmanniae combination, Caulis Spatholobi, Radix Arnebiae (Radix Lithospermi) combination, one or more in the Radix Angelicae Dahuricae, the Concha Ostreae combination are used with, and they are with wherein any effect of using with is suitable, many more its effects of the composition of using with are good more, and the effect that all the components is all used with is best.Other compositions are also like this.
Compositions of the present invention has no side effect, and can effect a radical cure vitiligo, and treatment cycle is short, rapid-action, below medicine of the present invention is carried out animal and clinical experiment, proves its effect.
One, toxicity test
Test method: get 80 of SD rats, body weight 180～220g, male and female half and half are equally divided into 8 groups with rat, respectively the medicine of feeding embodiment of the invention 1-8.The medicine feeding method is: with medicine pulverize of the present invention, water is made into suspension.Every group of rat three fillings every day stomach drug suspension, every day, the rat dosage was 1.5g/Kg, and water is can't help in the rat fasting, and method continuous irrigation stomach is 15 days like this.
The result: during the rat medication, rat does not all have poisoning, the phenomena of mortality, and each organizes activities in rats, appetite is normal.Have no significant change through dissection kidney, liver, adrenal cortex, genitals.
Conclusion: from The above results as can be seen, the used medication amount of zoopery exceeds the dose of adult's clinical application far away, but rat does not have death or organ variation situation takes place, and therefore can draw medicine of the present invention and have no side effect when human body uses.
Clinical experiment
1, case source
Choose 550 routine patients with vitiligo at each big Dermatology of this city, topical type among the patient, distribute type, acra type, no general hair style and all have.Male's 239 examples wherein, women's 311 examples, the course of disease is between half a year to 10 year, and average course of disease is 5.23, and patient age is at 20-50 between year.
2, test method
The patient is equally divided into 11 groups, and each organizes no difference of science of statistics, and every group of patient uses the medicine of the embodiment of the invention respectively, every day 3 times, each 4, takes continuously 2 months.
3, criterion of therapeutical effect
Produce effects: white macula complete obiteration or white macula area dwindle greater than 60%;
Effectively: the white macula area dwindles, and the white macula area dwindles greater than 40%;
Invalid: white macula no change or white macula area dwindle less than 10%.
4, therapeutic outcome
Each is organized the patient treatment situation and sees the following form.
Above-mentioned 550 routine patients when treatment the overwhelming majority show good effect, and rapid-action, through further taking this medicine, the patient all cures, the shortest healing time 2 months, healing 1 year time in Changzhi, pays a return visit no recidivist after the patient fully recovered 1 year.And during taking medicine, the generation that has no adverse reaction illustrates that medicine of the present invention has no side effect substantially to human body.
The therapeutic effect average price of medicinal raw material of the present invention made tablet, capsule, pill, granule after preparing, the dosage form of medicine can not play too big difference to therapeutic effect, and its curative effect is approximate, specifically no longer sets forth at this.
Model case
Chen, the man, 45 years old, white patch in blocks appearred in hand, face, cervical region, head, and ill 5 years, use medicine of the present invention, recovery from illness after 6 months, more the back does not have recurrence.
The Wang, the woman, 40 years old, the large tracts of land white macula, ill 1 year, have not yet fully recovered through multi-treatment, use medicine of the present invention to fully recover after 2 months.
Revive certain, the woman, 25 years old, hand, facial large tracts of land white macula, ill 1 year, use that the present invention is medicinal to be treated, recovery from illness in 2 months does not have recurrence.
Zhao, the man, 45 years old, multiple vitiligo, ill 10 years, permanent therapeutic effect was not satisfactory, eradicated always, uses Drug therapy of the present invention after, recovery from illness in 10 months, and pay a return visit after 1 year not have and recur.
Claims (10)
1. treat leukodermic Chinese medicine composition for one kind, it is characterized in that effective ingredient comprises following materials of weight proportions:
10～40 parts of Caulis Vernoniae andersoniis, 10～40 parts of Fructus Psoraleaes, 5～20 parts of Radix Plumbaginis Zeylanicaes, 5～30 parts in rattan of box fruit, 10～40 parts of Radix Angelicae Sinensis, 5～20 parts in Radix Rubiae, 10～20 parts of Radix Codonopsis.
2. Chinese medicine composition according to claim 1 is characterized in that effective ingredient comprises the raw material of following weight portion: 24 parts of Caulis Vernoniae andersoniis, 24 parts of Fructus Psoraleaes, 8 parts of Radix Plumbaginis Zeylanicaes, 12 parts in rattan of box fruit, 24 parts of Radix Angelicae Sinensis, 10 parts in Radix Rubiae, 15 parts of Radix Codonopsis.
3. Chinese medicine composition according to claim 1 and 2 is characterized in that effective ingredient also comprises the raw material of following weight portion: 5～20 parts of Rhizoma Alpiniae Officinarums.
4. Chinese medicine composition according to claim 1 and 2 is characterized in that effective ingredient also comprises the raw material of following weight portion: 5～30 parts of Cortex Moutans.
5. Chinese medicine composition according to claim 1 and 2 is characterized in that effective ingredient also comprises the raw material of following weight portion: 5～10 parts of Rhizoma Chuanxiongs, 10～15 parts of Fructus Ligustri Lucidi, 5～10 parts of Fructus Tribulis.
6. Chinese medicine composition according to claim 1 and 2 is characterized in that effective ingredient also comprises the raw material of following weight portion: 5～15 parts of Semen Cuscutae, 10～20 parts of Radix Rehmanniae.
7. Chinese medicine composition according to claim 1 and 2 is characterized in that effective ingredient also comprises the raw material of following weight portion: 1～15 part of Caulis Spatholobi, 10～20 parts of Radix Arnebiae (Radix Lithospermi)s.
8. Chinese medicine composition according to claim 1 and 2 is characterized in that effective ingredient also comprises the raw material of following weight portion: 10～30 parts of the Radixs Angelicae Dahuricae, 5～20 parts of Concha Ostreaes.
9. Chinese medicine composition according to claim 1 and 2 is characterized in that: dosage form is tablet, capsule, pill or granule.
10. the preparation method of the leukodermic Chinese medicine composition of the described treatment of claim 1 is characterized in that may further comprise the steps:
(1) Caulis Vernoniae andersonii is ground into fine powder, standby;
(2) remaining crude drug is mixed, with the ethanol extraction of 6～12 quality times 2 times, merge extractive liquid;
(3) extracting solution is condensed into thick paste, adds the fine powder of step (1) then in thick paste, the mix homogeneously after drying gets dry extract;
(4) dried cream powder is broken into fine powder, adds the adjuvant of survival dose, make the medicine of required dosage form.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579678A (en) * | 2012-04-11 | 2012-07-18 | 高天文 | Medicinal composition for treating vitligo |
| CN102908391A (en) * | 2012-11-06 | 2013-02-06 | 山东新宝医药有限公司 | Chinese medicinal composition for treating dermatosis and preparation method and application thereof |
| CN106421717A (en) * | 2016-11-26 | 2017-02-22 | 新疆维吾尔自治区维吾尔医药研究所 | Uighur medicine compound effective parts and effective part group for treating leucoderma and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049340A (en) * | 2006-04-05 | 2007-10-10 | 李秋科 | A pharmaceutical composition for treating vitiligo and its preparation method |
| CN101766779A (en) * | 2010-02-09 | 2010-07-07 | 闫明 | Compound medicine for vitligo treatment and preparation method thereof |
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2011
- 2011-07-11 CN CN2011101927069A patent/CN102228544B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049340A (en) * | 2006-04-05 | 2007-10-10 | 李秋科 | A pharmaceutical composition for treating vitiligo and its preparation method |
| CN101766779A (en) * | 2010-02-09 | 2010-07-07 | 闫明 | Compound medicine for vitligo treatment and preparation method thereof |
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| Title |
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| 《中外医疗》 20101231 陈国静等 驱白巴布期片治疗白癜风100例临床疗效研究 , 第28期 * |
| 《齐鲁药事》 20090715 张桂菊等 驱白巴布期片治疗白癜风的临床疗效观察 第28卷, 第07期 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579678A (en) * | 2012-04-11 | 2012-07-18 | 高天文 | Medicinal composition for treating vitligo |
| CN102908391A (en) * | 2012-11-06 | 2013-02-06 | 山东新宝医药有限公司 | Chinese medicinal composition for treating dermatosis and preparation method and application thereof |
| CN106421717A (en) * | 2016-11-26 | 2017-02-22 | 新疆维吾尔自治区维吾尔医药研究所 | Uighur medicine compound effective parts and effective part group for treating leucoderma and preparation method thereof |
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| CN102228544B (en) | 2012-07-04 |
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