CN101049340A - Composition of medication for treating leucoderma, and preparation method - Google Patents

Composition of medication for treating leucoderma, and preparation method Download PDF

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CN101049340A
CN101049340A CN 200610067143 CN200610067143A CN101049340A CN 101049340 A CN101049340 A CN 101049340A CN 200610067143 CN200610067143 CN 200610067143 CN 200610067143 A CN200610067143 A CN 200610067143A CN 101049340 A CN101049340 A CN 101049340A
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parts
fructus
treatment
leukodermic
radix
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李秋科
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李秋科
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Abstract

A composite medicine for treating leukoderma by interior or exterior application is prepared from 5 Chinese-medicinal materials including psoralea fruit, Chinese angelica root, ledebouriella root, cnidium fruit, etc. Its preparing process is also disclosed.

Description

Leukodermic drug regimen of a kind of treatment and preparation method thereof
One, technical field
The present invention relates to leukodermic drug regimen of a kind of treatment and preparation method thereof.
Two, background technology
Vitiligo is a kind of common depigmentation dermatoses, clinical manifestation be differ in size on the skin, shape differs, number is indefinite, well-defined depigmentation speckle, the traditional Chinese medical science is referred to as leucoderma, vitiligo.Though non-life threatening of vitiligo causes greatly with psychological pressure mentally to the patient, having a strong impact on work, study and social communication.According to statistics, China's vitiligo sickness rate accounts for dermopathic 0.54~1.03%; External report shows: U.S.'s vitiligo prevalence accounts for 1%, and Denmark accounts for 0.46%, and the India Surat accounts for 1.13%, and Calcutta accounts for 0.46%, and the French West Indies is reported as about 0.5~1%.Because the difficult always effectively Therapeutic Method of this sick etiology unknown, Chinese and western medicine.Doctor trained in Western medicine is treated with photochemotherapy usually, adds irradiation ultraviolet radiation behind the promptly oral 8-methoxyposoralen, continued treatment half a year to one year, just can obtain certain improvement.Chinese traditional treatment should the disease determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs a lot of methods such as internal treatment, external treatment, acupuncture and moxibustion treatment, scrape therapy, water phototherapy, the subcutaneous method of sunkening cord, but the course of treatment is long, also take continued treatment half a year to one year, and curative effect is limited, cure rate is low, generally is no more than 25%.The external therapy of Chinese herb vitiligo has certain curative effect, and side effect is less relatively.External treatment commonly used in general document record has following several: (1) psoralea tincture (Nanjing " hospital preparation standard " 1989) Fructus Psoraleae 300g, ethanol (75%) is an amount of.Get Fructus Psoraleae and be ground into coarse powder, add an amount of 75% ethanol lixiviate, be made into 1000ml, stir evenly, promptly.External takes a morsel and is coated with the affected part, is coated with back sun exposure 10 minutes, to heighten the effect of a treatment every day 1~2 time.(2) white macula tincture (Nanjing " hospital preparation standard " 1989) Fructus Psoraleae 60g, Semen Cuscutae 60g, Fructus Gardeniae 60g.More than 3 the flavor be ground into fine powder, with an amount of lixiviate of 70% ethanol.Get leachate 1000ml promptly.Affected part of exterior coating, every day 2 times.Behind the medicine, the affected part was shone 20 minutes under daylight.(3) tincture (" Shandong Province's drug standard " 1986) the Fructus Psoraleae 375g that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., Semen Cuscutae 563g, Nidus Vespae 281g, Mylabris (stir-fry) 0.3g.More than 4 the flavor, with 75% ethanol lixiviate, the collection extracting solution.(4) diffusing (" Jilin Province's hospital preparation standard ") Fructus Psoraleae 600g of vitiligo, Realgar 250g, above 3 flavors of Lithargyrum 250go are ground into fine powder.Cross 140 mesh sieves, mixing, promptly.The coating affected part is transferred in external, vinegar.Some oral and external used medicines in patent documentation, have also been announced, it as application number 95113704.2 the leukodermic compound Vernonia anthelmintica tablet of treatment, it comprises with Chinese medicine Caulis Vernoniae andersonii, Fructus Lycii, Fructus Psoraleae, Radix Polygoni Multiflori, Herba Ecliptae, Fructus Tribuli, Radix Rehmanniae, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, trace element copper sulfate is raw material, and also comprising with magnesium stearate, 10% starch gelatin slurry is the Chinese medicinal tablet that adjuvant is made.Usage: each 5 of adult's consumption, three times on the one, 30 days is a course of treatment.Application number is 200410075351.5 the leukodermic Chinese patent medicine of a kind of treatment, and it is standby to it is characterized in that choosing Caulis Vernoniae andersonii, the Radix Astragali, Semen Sesami Nigrum, Fructus Fici, Radix Salviae Miltiorrhizae, the Radix Angelicae Dahuricae, Fructus Psoraleae, Flos Carthami eight flavor pulverize at low temperature to 120 mesh sieve fine powders; With Cortex Dictamni, Fructus Tribuli, the Radix Polygoni Multiflori, Herba Ecliptae, Radix Arnebiae (Radix Lithospermi), the Poria Six-element is cataclasm, water decocts secondary, 3 hours for the first time, 2 hours for the second time, filter, discard residue, collecting decoction, filtrate is condensed into thick paste; Mix with standby fine powder, drying is ground into impalpable powder, and mixing carried out ripening, sterilization treatment 20~30 minutes under 100~110 ℃ of temperature, make powder; With the powder water pill, freeze-day with constant temperature is used the Pulvis Talci coating, and polishing makes pill; Powder is filled with the Capsules shell, and grain is picked up in polishing, makes capsule.Be oral formulations.Application number is a kind of treatment vitiligo medicine of 93114696.8, and it contains Caulis Vernoniae andersonii, Fructus Psoraleae, Fructus Mume, and dash by the material group that Flos Caryophylli, Semen Sinapis Albae, Semen Sesami Nigrum, azone are formed one or more.Application number is 01114723.7 a kind of Kebai Tincture, its preparation method and application, by Mylabris 30~70 grams, and Fructus Psoraleae 100~300 grams, Pericarpium Citri Reticulatae 50~200 grams, 1000 milliliters of compositions of 75%~95% ethanol.Application number is 03118540.1 the leukodermic compound recipe Fructus Psoraleae of treatment preparation, it be by the alcohol-pickled liquid of mending bone ester, Semen Cuscutae, the Fructus Kochiae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Carthami, Radix Sophorae Flavescentis add azone, dexamethasone or and Le-Fu-Ye bacteriostatic formulated.Application number is 200410044147.7 treatment vitiligo Chinese herbal medicine liniment, and it comprises Fructus Atriplicis Sibiricae, Flos Carthami, Fructus Psoraleae, melanin.Fructus Atriplicis Sibiricae, Flos Carthami, Fructus Psoraleae, melanic ratio are 1: 1: 1: 5; Preparation method is that waste is got leachate after getting Fructus Atriplicis Sibiricae 1000g, Flos Carthami 1000g, Fructus Psoraleae 1000g and soaking 3 days with 75% medical ethanol respectively, Fructus Psoraleae mixed with Flos Carthami, Fructus Atriplicis Sibiricae, the melanin mix homogeneously through being concentrated into 1000ml and 5000g.Above preparation or patent weak point are: curative effect is low, the course of treatment is long, and the external preparation side effect that part contains toxic medicament such as Mylabris, Lithargyrum is bigger.The present invention be with form through clinical screening for many years through proved recipe, characteristics such as have determined curative effect, short treating period, few side effects, relapse rate is low, preparing process is simple, price is low.
Three, summary of the invention
The object of the present invention is to provide a kind of determined curative effect, short treating period, few side effects, relapse rate is low, preparing process is simple, price is low leukodermic drug regimen of treatment and preparation method thereof, be applicable to patients with vitiligo.
Technical scheme of the present invention: the leukodermic drug regimen of a kind of treatment is to be that main medicine is made by Caulis Vernoniae andersonii, Fructus Psoraleae, Radix Angelicae Sinensis, Radix Saposhnikoviae, Fructus Cnidii, it is characterized in that the medicament that mainly is prepared from by following raw material composition and weight proportion: 10~60 parts of Caulis Vernoniae andersoniis, 10~60 parts of Fructus Psoraleaes, 5~50 parts of Radix Angelicae Sinensis, 5~50 parts of Radix Saposhnikoviaes, 5~50 parts of Fructus Cnidiis; Preferred weight ratio range of the present invention is: 20~50 parts of Caulis Vernoniae andersoniis, 20~50 parts of Fructus Psoraleaes, 10~40 parts of Radix Angelicae Sinensis, 10~40 parts of Radix Saposhnikoviaes, 10~40 parts of Fructus Cnidiis; Optimum weight ratio range of the present invention is: 30 parts of Caulis Vernoniae andersoniis, 30 parts of Fructus Psoraleaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Saposhnikoviaes, 20 parts of Fructus Cnidiis.
This prescription also can add 10~40 parts of Rhizoma Et Radix Notopterygiis and or 10~40 parts of increases of Radix Angelicae Pubescentis dispeiling pathogenic wind and removing dampness effect.
This prescription also can add 10~40 parts of Flos Caryophyllis and or 10~40 parts of increases of Fructus Foeniculi dispelling cold by warming the meridian effect.
This prescription also can add 10~40 parts on Flos Carthami, and Semen Persicae increases function of promoting blood circulation to disperse blood clots for 10~40 parts.
This prescription also can add 10~40 parts of Cortex Dictamni, and Semen Sinapis Albae increases the eliminating dampness and dredging channels effect for 10~40 parts.
This prescription also can add 10~40 parts of Radix Polygoni Multiflori, and Fructus Mume increases the effect of the kidney invigorating skin moistening for 10~40 parts.
A kind of preparation method for the treatment of leukodermic drug regimen is characterized in that it is by above-mentioned raw materials combination and weight proportion, is ground into coarse powder, carry out percolation after 1~3 day with 50~70% soak with ethanol, collect percolate, medicinal residues add 50~70% ethanol, reflux, extract, 2~6 hours filters, and filtrate and above-mentioned percolate merge, add the fine and soft ketone of 2% nitrogen, mixing left standstill 24 hours, filter, filtrate adds 60% ethanol and adjusts the ethanol total amount, mixing, promptly.
As above-mentioned a kind of preparation method for the treatment of leukodermic drug regimen, it is characterized in that the dosage form by above-mentioned raw materials combination and weight proportion preparation is any dosage form that adopts pharmaceutically acceptable carrier or excipient to make, as tincture, granule, tablet, capsule, soft capsule, drop pill, pill etc.
The invention has the advantages that the prescription uniqueness, determined curative effect, short treating period, few side effects, relapse rate is low, preparing process is simple, price is low, has warm skin cold expelling, dispeiling pathogenic wind and removing dampness, soothing the channels and quicking the network vessels, and the effect of blood circulation promoting and blood stasis dispelling is applicable to patients with vitiligo external or for oral administration.The present invention it be with form through clinical screening for many years through proved recipe, its characteristics are to improve the microcirculation of lesions position skin, directly trace element supplement, increase the photosensitization of skin, activity of tyrosinase promotes melanic synthesizing in the skin, increases pigmentation.Modern pharmacological research shows that effect of the present invention mainly shows following several respects: (1) activity of tyrosinase: tryrosinase is the biosynthetic key enzyme of skin melanocyte, its activity is relevant with the melanocyte synthetic quantity, increases the growing amount that its vigor can increase melanocyte.Caulis Vernoniae andersonii, Fructus Psoraleae, Fructus Cnidii, Cortex Dictamni, Fructus Mume, Radix Saposhnikoviae, Radix Angelicae Sinensis all have activation to tryrosinase in this prescription of modern pharmacological research, and tyrosinase activity and melanocyte growing amount all are the dose dependent activation.This medicine up to 73.18%, is 2.7 times of psoralea tincture to the activity ratio of tryrosinase after testing.(2) improve the skin photosensitization: contain the ultraviolet photosensitive material of absorption psoralen and isopsoralen one by one in this prescription in the medicines such as Fructus Psoraleae, Radix Polygoni Multiflori, Fructus Cnidii, Radix Saposhnikoviae, Cortex Dictamni, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, can improve skin to ultraviolet sensitivity, suppress the sulfydryl in the epidermis, increase tyrosinase activity and stimulate melanocyte to make its restore funcitons, the skin melanin regeneration.(3) direct local trace element supplement: medicine such as this prescription Caulis Vernoniae andersonii is rich in the human body various trace elements after testing, and is as copper, zinc, ferrum, manganese, cobalt, selenium etc., wherein the closest with the relation of copper, zinc and primary disease.Copper ion is the activator of tryrosinase, contains the zinc of high concentration in the melanin granule, lacks trace element such as copper, zinc, ferrum, manganese and can make tyrosinase activity reduce the melanocyte biosynthesis block.Patients with vitiligo is carried out trace elements determination can be found, most patient's bodies are interior and have no lack of trace element, are to lack in the local white macula.This product can direct local trace element supplement, thereby can effectively activate tryrosinase, promotes melanocyte synthetic.(4) improve the local microcirculation obstacle: microcirculation and vitiligo have close association, microcirculation mensuration is carried out at the white macula position also can be found, on the skin of the same area, the blood capillary number of suffering from the vitiligo position will lack more than the normal skin position, show that the white macula happening part exists microcirculation disturbance, make nutritional labeling can not deliver to each position of skin, melanocyte can not normally be nourished and influenced its growth promoter, metabolism.Year in and year out, the melanocyte dyspoiesis, melanin takes off mistake, thereby the local skin decolouring is bleached, and the vitiligo focus occurs.This prescription has warm skin cold expelling, dispeiling pathogenic wind and removing dampness, soothing the channels and quicking the network vessels, and the effect of blood circulation promoting and blood stasis dispelling can be improved the microcirculation of lesions position skin, corrects qi depression to blood stasis, blockage of meridian and failure of skin and muscle to be nourished state, thereby promotes melanocyte synthetic.Modern study shows that medicines energy blood vessel dilating such as Fructus Psoraleae, Cortex Dictamni, Caulis Vernoniae andersonii, Flos Carthami, Semen Persicae improve local organization nutrition in this prescription, and skin pigment is increased.
Four, the specific embodiment
With specific embodiment the present invention is elaborated below:
Embodiment 1:
Take by weighing raw material according to following proportioning: 15 parts of Caulis Vernoniae andersoniis, 15 parts of Fructus Psoraleaes, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Saposhnikoviaes, 10 parts of Fructus Cnidiis.
Preparation method: above-mentioned raw materials is ground into coarse powder, carries out percolation after 1~3 day, collect percolate with 50~70% soak with ethanol, medicinal residues add 50~70% ethanol, and reflux, extract, 2~6 hours filters, filtrate and above-mentioned percolate merge, add the fine and soft ketone of 2% nitrogen, mixing left standstill 24 hours, filter, filtrate adds 60% ethanol and adjusts the ethanol total amount, mixing, promptly.
Wherein, finished dosage forms is any dosage form that adopts pharmaceutically acceptable carrier or excipient to make, as tincture, granule, tablet, capsule, soft capsule, drop pill, pill etc.Down together.
Embodiment 2:
Take by weighing raw material according to following proportioning: 55 parts of Caulis Vernoniae andersoniis, 55 parts of Fructus Psoraleaes, 45 parts of Radix Angelicae Sinensis, 45 parts of Radix Saposhnikoviaes, 45 parts of Fructus Cnidiis.
Preparation method: above-mentioned raw materials is ground into coarse powder, carries out percolation after 1~3 day, collect percolate with 50~70% soak with ethanol, medicinal residues add 50~70% ethanol, and reflux, extract, 2~6 hours filters, filtrate and above-mentioned percolate merge, add the fine and soft ketone of 2% nitrogen, mixing left standstill 24 hours, filter, filtrate adds 60% ethanol and adjusts the ethanol total amount, mixing, promptly.
Embodiment 3:
Take by weighing raw material according to following proportioning: 30 parts of Caulis Vernoniae andersoniis, 30 parts of Fructus Psoraleaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Saposhnikoviaes, 20 parts of Fructus Cnidiis.
Preparation method: above-mentioned raw materials is ground into coarse powder, carries out percolation after 1~3 day, collect percolate with 50~70% soak with ethanol, medicinal residues add 50~70% ethanol, and reflux, extract, 2~6 hours filters, filtrate and above-mentioned percolate merge, add the fine and soft ketone of 2% nitrogen, mixing left standstill 24 hours, filter, filtrate adds 60% ethanol and adjusts the ethanol total amount, mixing, promptly.
Embodiment 4:
Take by weighing raw material according to following proportioning: 30 parts of Caulis Vernoniae andersoniis, 30 parts of Fructus Psoraleaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Saposhnikoviaes, 20 parts of Fructus Cnidiis, 15 parts of Rhizoma Et Radix Notopterygiis, 15 parts of Radix Angelicae Pubescentiss.
Preparation method: above-mentioned raw materials is ground into coarse powder, carries out percolation after 1~3 day, collect percolate with 50~70% soak with ethanol, medicinal residues add 50~70% ethanol, and reflux, extract, 2~6 hours filters, filtrate and above-mentioned percolate merge, add the fine and soft ketone of 2% nitrogen, mixing left standstill 24 hours, filter, filtrate adds 60% ethanol and adjusts the ethanol total amount, mixing, promptly.
Embodiment 5:
Take by weighing raw material according to following proportioning: 30 parts of Caulis Vernoniae andersoniis, 30 parts of Fructus Psoraleaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Saposhnikoviaes, 20 parts of Fructus Cnidiis, 15 parts of Flos Caryophyllis, 15 parts of Fructus Foeniculi.
Preparation method: above-mentioned raw materials is ground into coarse powder, carries out percolation after 1~3 day, collect percolate with 50~70% soak with ethanol, medicinal residues add 50~70% ethanol, and reflux, extract, 2~6 hours filters, filtrate and above-mentioned percolate merge, add the fine and soft ketone of 2% nitrogen, mixing left standstill 24 hours, filter, filtrate adds 60% ethanol and adjusts the ethanol total amount, mixing, promptly.
Embodiment 6:
Take by weighing raw material according to following proportioning: 30 parts of Caulis Vernoniae andersoniis, 30 parts of Fructus Psoraleaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Saposhnikoviaes, 20 parts of Fructus Cnidiis, 15 parts on Flos Carthami, 15 parts in Semen Persicae.
Preparation method: above-mentioned raw materials is ground into coarse powder, carries out percolation after 1~3 day, collect percolate with 50~70% soak with ethanol, medicinal residues add 50~70% ethanol, and reflux, extract, 2~6 hours filters, filtrate and above-mentioned percolate merge, add the fine and soft ketone of 2% nitrogen, mixing left standstill 24 hours, filter, filtrate adds 60% ethanol and adjusts the ethanol total amount, mixing, promptly.
Embodiment 7:
Take by weighing raw material according to following proportioning: 30 parts of Caulis Vernoniae andersoniis, 30 parts of Fructus Psoraleaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Saposhnikoviaes, 20 parts of Fructus Cnidiis, 20 parts of Cortex Dictamni, 10 parts of Semen Sinapis Albaes.
Preparation method: above-mentioned raw materials is ground into coarse powder, carries out percolation after 1~3 day, collect percolate with 50~70% soak with ethanol, medicinal residues add 50~70% ethanol, and reflux, extract, 2~6 hours filters, filtrate and above-mentioned percolate merge, add the fine and soft ketone of 2% nitrogen, mixing left standstill 24 hours, filter, filtrate adds 60% ethanol and adjusts the ethanol total amount, mixing, promptly.
Embodiment 8:
Take by weighing raw material according to following proportioning: 30 parts of Caulis Vernoniae andersoniis, 30 parts of Fructus Psoraleaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Saposhnikoviaes, 20 parts of Fructus Cnidiis, 10 parts of Radix Polygoni Multiflori, 15 parts of Fructus Mumes.
Preparation method: above-mentioned raw materials is ground into coarse powder, carries out percolation after 1~3 day, collect percolate with 50~70% soak with ethanol, medicinal residues add 50~70% ethanol, and reflux, extract, 2~6 hours filters, filtrate and above-mentioned percolate merge, add the fine and soft ketone of 2% nitrogen, mixing left standstill 24 hours, filter, filtrate adds 60% ethanol and adjusts the ethanol total amount, mixing, promptly.
Embodiment 9:
Take by weighing raw material according to following proportioning: 30 parts of Caulis Vernoniae andersoniis, 30 parts of Fructus Psoraleaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Saposhnikoviaes, 20 parts of Fructus Cnidiis, 15 parts of Rhizoma Et Radix Notopterygiis, 15 parts of Radix Angelicae Pubescentiss, 15 parts on Flos Carthami, 15 parts in Semen Persicae, 10 parts of Radix Polygoni Multiflori, 15 parts of Fructus Mumes, 15 parts of Flos Caryophyllis, 15 parts of Fructus Foeniculi, 20 parts of Cortex Dictamni, 10 parts of Semen Sinapis Albaes.
Preparation method: above-mentioned raw materials is ground into coarse powder, carries out percolation after 1~3 day, collect percolate with 50~70% soak with ethanol, medicinal residues add 50~70% ethanol, and reflux, extract, 2~6 hours filters, filtrate and above-mentioned percolate merge, add the fine and soft ketone of 2% nitrogen, mixing left standstill 24 hours, filter, filtrate adds 60% ethanol and adjusts the ethanol total amount, mixing, promptly.

Claims (10)

1, the leukodermic drug regimen of a kind of treatment is characterized in that the medicament that mainly is prepared from by following primary raw material and weight proportion: 10~60 parts of Caulis Vernoniae andersoniis, 10~60 parts of Fructus Psoraleaes, 5~50 parts of Radix Angelicae Sinensis, 5~50 parts of Radix Saposhnikoviaes, 5~50 parts of Fructus Cnidiis.
2, as the leukodermic drug regimen of claims 1 described a kind of treatment, the weight proportion of its raw material is: 20~50 parts of Caulis Vernoniae andersoniis, 20~60 parts of Fructus Psoraleaes, 10~40 parts of Radix Angelicae Sinensis, 10~40 parts of Radix Saposhnikoviaes, 10~40 parts of Fructus Cnidiis.
3, as the leukodermic drug regimen of claims 1,2 described a kind of treatments, the weight proportion of its raw material is: 30 parts of Caulis Vernoniae andersoniis, 30 parts of Fructus Psoraleaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Saposhnikoviaes, 20 parts of Fructus Cnidiis.
4,, it is characterized in that its prescription also comprises and add 10~40 parts of Rhizoma Et Radix Notopterygiis and or 10~40 parts of Radix Angelicae Pubescentiss as the leukodermic drug regimen of claims 1~3 described a kind of treatment.
5,, it is characterized in that its prescription also comprises and add 10~40 parts of Flos Caryophyllis and or 10~40 parts of Fructus Foeniculi as the leukodermic drug regimen of claims 1~4 described a kind of treatment.
6,, it is characterized in that its prescription also comprises 10~40 parts on adding Flos Carthami, 10~40 parts in Semen Persicae as the leukodermic drug regimen of claims 1~5 described a kind of treatment.
7,, it is characterized in that its prescription also comprises 10~40 parts of adding Cortex Dictamni, 10~40 parts of Semen Sinapis Albaes as the leukodermic drug regimen of claims 1~5 described a kind of treatment.
8,, it is characterized in that its prescription also comprises 10~40 parts of adding Radix Polygoni Multiflori, 10~40 parts of Fructus Mumes as the leukodermic drug regimen of claims 1~5 described a kind of treatment.
9, as claims 1~8 described a kind of preparation method for the treatment of leukodermic drug regimen, it is characterized in that it is by above-mentioned raw materials and combination matching, is ground into coarse powder, carry out percolation after 1~3 day with 50~70% soak with ethanol, collect percolate, medicinal residues add 50~70% ethanol, reflux, extract, 2~6 hours filters, and filtrate and above-mentioned percolate merge, add the fine and soft ketone of 2% nitrogen, mixing left standstill 24 hours, filter, filtrate adds 60% ethanol and adjusts the ethanol total amount, mixing, promptly.
10,, it is characterized in that by above-mentioned raw materials and combination matching dosage form be any dosage form that adopts pharmaceutically acceptable carrier or excipient to make as claims 9 described a kind of preparation methoies for the treatment of leukodermic drug regimen.
CN 200610067143 2006-04-05 2006-04-05 Composition of medication for treating leucoderma, and preparation method Pending CN101049340A (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101306141B (en) * 2008-06-06 2011-10-26 叶志军 Decoction for treating qi-blood disharmony type vitiligo
CN102228544A (en) * 2011-07-11 2011-11-02 山东新宝医药有限公司 Traditional Chinese medicine composition for treating leucoderma and preparation method thereof
CN103230584A (en) * 2013-03-26 2013-08-07 成进学 Cobalt, copper, selenium, traditional Chinese medicine element, and vitamin leucoderma-treating external medicinal liquor
CN103461611A (en) * 2013-10-09 2013-12-25 北京绿源求证科技发展有限责任公司 Food health tea infusion dissolved medicine for improving vitiligo
CN103933336A (en) * 2014-04-15 2014-07-23 郎溪县志瑞企业信息服务有限公司 Traditional Chinese medicine combination for treating leucoderma
CN111317810A (en) * 2020-04-21 2020-06-23 佰氏健康(广州)大健康科技有限公司 Traditional Chinese medicine for treating leucoderma

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101306141B (en) * 2008-06-06 2011-10-26 叶志军 Decoction for treating qi-blood disharmony type vitiligo
CN102228544A (en) * 2011-07-11 2011-11-02 山东新宝医药有限公司 Traditional Chinese medicine composition for treating leucoderma and preparation method thereof
CN102228544B (en) * 2011-07-11 2012-07-04 山东新宝医药有限公司 Traditional Chinese medicine composition for treating leucoderma and preparation method thereof
CN103230584A (en) * 2013-03-26 2013-08-07 成进学 Cobalt, copper, selenium, traditional Chinese medicine element, and vitamin leucoderma-treating external medicinal liquor
CN103461611A (en) * 2013-10-09 2013-12-25 北京绿源求证科技发展有限责任公司 Food health tea infusion dissolved medicine for improving vitiligo
CN103933336A (en) * 2014-04-15 2014-07-23 郎溪县志瑞企业信息服务有限公司 Traditional Chinese medicine combination for treating leucoderma
CN111317810A (en) * 2020-04-21 2020-06-23 佰氏健康(广州)大健康科技有限公司 Traditional Chinese medicine for treating leucoderma

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