CN102908391A - Chinese medicinal composition for treating dermatosis and preparation method and application thereof - Google Patents
Chinese medicinal composition for treating dermatosis and preparation method and application thereof Download PDFInfo
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Abstract
Description
技术领域 technical field
本发明涉及一种治疗皮肤病的药物,具体涉及一种治疗白癜风和银屑病的中药组合物,属于医药技术领域。 The invention relates to a medicine for treating skin diseases, in particular to a traditional Chinese medicine composition for treating vitiligo and psoriasis, and belongs to the technical field of medicine.
背景技术 Background technique
白癜风(vitiligo)是一种后天性黑色素脱失性皮肤病,在临床上表现为大小不等、形态不一的色素脱失斑,数目不定,边缘清楚,有的白斑外围正常皮肤处色素增加。白癜风的白斑可发生于全身任何部位,但以面部、颈部、手背等暴露部位及外生殖器等皱褶处皮肤多见,由于白斑暴露于可视部位会影响患者的容貌,进而还会影响到患者的正常生活,造成很大的心理压力,因此求治者很多,而且都很迫切。 Vitiligo (vitiligo) is an acquired depigmentation skin disease, clinically manifested as depigmentation spots of different sizes and shapes, the number is indefinite, the edges are clear, and some of the normal skin around the leukoplakia increases in pigment. Vitiligo can occur in any part of the body, but it is more common in exposed parts such as the face, neck, back of the hand, and skin in the folds of the external genitalia. Exposure of the leukoplakia to visible parts will affect the appearance of the patient, and in turn affect the appearance of the patient. The normal life of the patient causes a lot of psychological pressure, so there are many people seeking treatment, and they are all urgent.
银屑病俗称牛皮癣,发病率高,病程较长,发病机制涉及遗传免疫、炎症介质、神经介质、细胞增殖与凋亡、微循环障碍等诸多因素。银屑病患者遍布世界各地,在不同民族、性别、年龄均可发病。据国内文献报道,我国银屑病患者发病率约占总人口的0.5%~2%,大约有10%~30%的银屑病患者有家族史,该病由于其慢性、缠绵反复、顽固难愈、复发率高等原因严重影响患者的社会生活,造成极大的身体和心理上的痛苦。同时,由于该病反复发作,常需反复治疗,也给患者带来沉重的经济负担。 Psoriasis, commonly known as psoriasis, has a high incidence rate and a long course of disease. The pathogenesis involves genetic immunity, inflammatory mediators, nerve mediators, cell proliferation and apoptosis, and microcirculation disorders. Patients with psoriasis can be found all over the world, and can occur in different ethnic groups, genders, and ages. According to domestic literature reports, the incidence of psoriasis patients in my country accounts for about 0.5% to 2% of the total population, and about 10% to 30% of psoriasis patients have family history. Healing, high recurrence rate and other reasons seriously affect the social life of patients, causing great physical and psychological pain. At the same time, due to the recurrent outbreak of the disease, repeated treatment is often required, which also brings a heavy economic burden to the patient.
现今有很多治疗白癜风和银屑病的药物,既有中药也有西药,虽然都能起到一定的作用,但是不能根治,容易复发,药物依赖性强。如何治疗白癜风和银屑病已是世界医学领域的一大难题,是国内外皮肤领域重点研究防治的疾病之一。 Nowadays, there are many medicines for treating vitiligo and psoriasis, both traditional Chinese medicine and western medicine. Although they can all play a certain role, they cannot be cured, and they are easy to relapse and have strong drug dependence. How to treat vitiligo and psoriasis has become a major problem in the field of medicine in the world, and it is one of the diseases that are mainly researched and prevented in the field of skin at home and abroad.
发明内容 Contents of the invention
为了克服现有技术的不足,本发明提供了一种治疗皮肤病的中药组合物,该中药组合物对白癜风和银屑病具有稳定性高、治疗效果好的优点。 In order to overcome the shortcomings of the prior art, the invention provides a traditional Chinese medicine composition for treating skin diseases, which has the advantages of high stability and good therapeutic effect on vitiligo and psoriasis.
本发明还公开了该组合物的制备方法和应用,其制备简单,疗效显著,便于工业化大应用。 The invention also discloses a preparation method and application of the composition, which has simple preparation, remarkable curative effect and is convenient for large-scale industrial application.
本发明是通过以下技术方案实现的: The present invention is achieved through the following technical solutions:
一种治疗皮肤病的中药组合物,包括下列重量份的原料:驱虫斑鸠菊30~60份、补骨脂30~60份、当归15~30份、五味子(酒制)10~20份、白花丹10~20份。 A traditional Chinese medicine composition for treating skin diseases, comprising the following raw materials in parts by weight: 30-60 parts of vernonia anthelmintic, 30-60 parts of psoralen, 15-30 parts of angelica, 10-20 parts of schisandra (made from wine), 10-20 parts of plum blossom.
上述中药组合物中,优选包括下列重量份的原料:驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份。 The above traditional Chinese medicine composition preferably includes the following raw materials in parts by weight: 36 parts of Vernonia anthelminticus, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (made from wine), and 12 parts of plumbago.
本发明的主要配方原料为驱虫斑鸠菊、补骨脂、当归、五味子、白花丹,各原料药功效如下: The main formula raw materials of the present invention are anthelmintic vernonia, psoralen, angelica, schisandra, plumbago, and the efficacy of each raw material is as follows:
驱虫斑鸠菊,菊科植物驱虫斑鸠菊Vernonia anthelmintica Willd的成熟果实。秋季采收果实,晒干。主要产于新疆的喀什、阿克苏地区、维吾尔名阿特里拉,具有清热消炎,活血化瘀,杀虫的功能,用于治疗皮肤病。 Vernonia anthelmintica, the ripe fruit of Vernonia anthelmintica Willd, a plant of Compositae. The fruit is harvested in autumn and dried in the sun. Mainly produced in Kashgar and Aksu areas of Xinjiang, Uighur name Atrila, has the functions of clearing away heat and reducing inflammation, promoting blood circulation and removing blood stasis, and killing insects, and is used to treat skin diseases.
补骨脂,豆科植物补骨脂Psoralea corylifolia L.的干燥成熟果实,具有温肾助阳,纳气平喘,湿脾止泻的功能,用于肾阳不足,阳痿遗精,遗尿尿频,腰膝冷痛,肾虚作喘,五更泄泻,外用治白癜风,斑秃。 Psoralea, leguminous plant Psoralea corylifolia L. The dried and mature fruit of the herb has the functions of warming the kidney and supporting yang, inducing Qi to relieve asthma, and dampening the spleen to relieve diarrhea. It is used for deficiency of kidney yang, impotence and nocturnal emission, enuresis, frequent urination, cold pain in the waist and knees, asthma caused by kidney deficiency, and diarrhea at dawn. External use Cure vitiligo, alopecia areata.
当归,伞形科植物当归Angelica sinensis(Oliv.)Diels的干燥根,具有补血活血、调经止痛、润肠通便的功能,用于血虚萎黄,眩晕心悸,月经不调,经闭痛经,虚寒腹痛,风湿痹痛,跌扑损伤,痈疽疮疡,肠燥便秘。 Angelica sinensis, the dried root of Angelica sinensis (Oliv.) Diels, a Umbelliferae plant, has the functions of nourishing blood and promoting blood circulation, regulating menstruation, relieving pain, and laxative. Cold abdominal pain, rheumatic arthralgia, injury from falling, carbuncle sores, intestinal dryness and constipation.
五味子,木兰科植物五味子Schisandra chinensis(Turcz.)Baill.的干燥成熟果实,习称“北五味子”,具有收敛固涩、益气生津、补肾宁心的功能,用于久嗽虚喘,梦遗滑精,遗尿尿频,久泻不止,自汗盗汗,津伤口渴,内热消渴,心悸失眠。 Schisandra chinensis, the dried and mature fruit of Schisandra chinensis (Turcz.) Baill. , enuresis, frequent urination, chronic diarrhea, spontaneous sweating, thirsty wounds, internal heat and thirst, palpitations and insomnia.
白花丹,白花丹科植物白花丹Plumbago zeylanis L.不带叶的干燥茎枝,全年可采,具有祛风散瘀、解毒杀虫的功能,用于治肿毒恶疮,疥癣。 Plumbago zeylanis, Plumbago zeylanis L. The dry stems and branches without leaves of Plumbago zeylanis L. can be harvested throughout the year. It has the functions of dispelling wind and blood stasis, detoxifying and killing insects.
本发明以驱虫斑鸠菊、补骨脂为主,辅以其他药物成分,活血凉血、祛风散寒、散瘀化瘀、杀虫疗癣,从根本上解决了白癜风和银屑病的发病原因,直除病灶,达到根治的目的。 The present invention mainly uses vernonia and psoralen as the main ingredients, supplemented by other medicinal ingredients, promotes blood circulation and cools blood, dispels wind and cold, dissipates blood stasis and removes blood stasis, kills insects and treats ringworm, and fundamentally solves the problems of vitiligo and psoriasis. The cause of the disease is directly removed from the focus to achieve the purpose of a radical cure.
在原有配方的基础上,还可以加入其他一些增效原料加强疗效,例如可以进一步加入黄芪、川芎,起到散瘀托毒、补气固表的作用,所形成的新方为(重量份):驱虫斑鸠菊30~60份、补骨脂30~60份、当归15~30份、五味子(酒制)10~20份、白花丹10~20份、黄芪10~40份、川芎9~18份,优选重量份为:驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、黄芪25份、川芎12份。 On the basis of the original formula, some other synergistic raw materials can also be added to enhance the curative effect. For example, astragalus and chuanxiong can be further added to play the role of dispelling blood stasis and supporting poison, invigorating qi and strengthening the surface. The new formula formed is (parts by weight) : 30-60 parts of vernonia, 30-60 parts of psoralen, 15-30 parts of angelica, 10-20 parts of schisandra (wine), 10-20 parts of plumbago, 10-40 parts of astragalus, 9-40 parts of chuanxiong 18 parts, the preferred parts by weight are: 36 parts of Vernonia anthelminticus, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plumbago, 25 parts of astragalus, and 12 parts of chuanxiong.
在原有配方的基础上,还可以加入拳参、防风、川芎、粉萆薢形成新的子方,拳参清热解毒、消肿止血,防风解表祛风、止痛止痉,川芎活血行气、祛风止痛,粉萆薢利湿去浊、祛风除痹,新的子方为(重量份):驱虫斑鸠菊30~60份、补骨脂30~60份、当归15~30份、五味子(酒制)10~20份、白花丹10~20份、拳参8~20份、防风9~18份、川芎9~18份、粉萆薢16~32份,优选重量份为:驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、拳参10份、防风10份、川芎12份、粉萆薢20份。 On the basis of the original formula, you can also add boxing ginseng, Fangfeng, Chuanxiong, and Fenxiong to form a new sub-prescription. Wind relieves pain, Fenji scorpion promotes dampness and removes turbidity, dispels wind and eliminates numbness, the new sub-prescriptions are (parts by weight): 30-60 parts of vernonia anthelmintic, 30-60 parts of psoralen, 15-30 parts of angelica, schisandra ( Liquor system) 10-20 parts, Plumbago 10-20 parts, ginseng 8-20 parts, Fangfeng 9-18 parts, Chuanxiong 9-18 parts, fennel 16-32 parts, the preferred parts by weight are: insect repellent Vernonia 36 parts, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plum blossom, 10 parts of boxing ginseng, 10 parts of Fangfeng, 12 parts of Chuanxiong, and 20 parts of fennel.
在原有配方的基础上,还可以加入高良姜、白芷、地肤子形成新的子方,高良姜温胃止呕、散寒止痛,白芷解表散寒,祛风止痛、消肿排脓,地肤子清热利湿、祛风止痒,新的子方为(重量份):驱虫斑鸠菊30~60份、补骨脂30~60份、当归15~30份、五味子(酒制)10~20份、白花丹10~20份、高良姜5~30份、白芷20~30份、地肤子10~20份,优选重量份为:驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、高良姜18份、白芷25份、地肤子15份。 On the basis of the original formula, galangal, angelica dahurica and Kochia scoparia can be added to form a new sub-prescription. Kochia chinensis clears away heat and promotes dampness, dispels wind and relieves itching, and the new sub-prescriptions are (parts by weight): 30-60 parts of Vernonia anthelminticus, 30-60 parts of psoralen, 15-30 parts of angelica, schisandra (wine) 10-20 parts, Plumbago 10-20 parts, Galangal 5-30 parts, Angelica dahurica 20-30 parts, Kochia scoparia 10-20 parts, the preferred parts by weight are: Vernonia 36 parts, Psoralen psoraleae 36 parts , 18 parts of angelica, 18 parts of schisandra (wine system), 12 parts of plumbago, 18 parts of galangal, 25 parts of angelica, 15 parts of Kochia scoparia.
在原有配方的基础上,还可以加入牡蛎,牡蛎具有潜阳补阴、软坚散结的功效,还可以补充微量元素,新的子方为(重量份):驱虫斑鸠菊30~60份、补骨脂30~60份、当归15~30份、五味子(酒制)10~20份、白花丹10~20份、牡蛎5~30份,优选重量份为:驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、牡蛎10份。 On the basis of the original formula, oysters can also be added. Oysters have the effects of suppressing yang and nourishing yin, softening and resolving stagnation, and can also supplement trace elements. 30-60 parts of psoralen, 15-30 parts of angelica, 10-20 parts of schisandra (wine system), 10-20 parts of plumbago, 5-30 parts of oyster, the preferred parts by weight are: 36 parts of repellent vernonia, 36 parts of bone fat, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plum blossom, 10 parts of oyster.
在原有配方的基础上,还可以加入土茯苓、白鲜皮、蒲公英、马齿苋,土茯苓为百合科植物光叶菝葜Smilax glabra Roxb.的干燥根茎,别称禹余粮、刺猪苓、过山龙,具有解毒除湿的功效,白鲜皮具有清热燥湿、祛风解毒的功效,蒲公英具有清热解毒、消肿散结的功效,马齿苋具有清热解毒、凉血止血的功效,新的子方为(重量份):驱虫斑鸠菊30~60份、补骨脂30~60份、当归15~30份、五味子(酒制)10~20份、白花丹10~20份、土茯苓30~40份、白鲜皮10~25份、蒲公英20~25份、马齿苋10~20份,优选重量份为:驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、土茯苓35份、白鲜皮15份、蒲公英22份、马齿苋15份。 On the basis of the original formula, you can also add Smilax smilax glabra Roxb., Smilax glabra Roxb. Mountain dragon has the effect of detoxification and dehumidification, white fresh skin has the effect of clearing heat and dampness, dispelling wind and detoxification, dandelion has the effect of clearing heat and detoxification, reducing swelling and dispelling stagnation, purslane has the effect of clearing heat and detoxification, cooling blood and stopping bleeding, new The sub-prescriptions are (parts by weight): 30-60 parts of vernonia anthelmintic, 30-60 parts of psoralen, 15-30 parts of angelica, 10-20 parts of schisandra (wine), 10-20 parts of plumbago, smilax smilax 30-40 parts, 10-25 parts of white fresh skin, 20-25 parts of dandelion, 10-20 parts of purslane, the preferred parts by weight are: 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, schisandra (Wine system) 18 parts, plum flower 12 parts, smilax 35 parts, white fresh skin 15 parts, dandelion 22 parts, purslane 15 parts.
在原有配方的基础上,还可以加入降香、三七、桃仁、红花,降香行气活血、理气止痛,三七散瘀止血、消肿定痛,桃仁活血祛瘀,红花活血通经、散瘀止痛,新的子方为(重量份):驱虫斑鸠菊30~60份、补骨脂30~60份、当归15~30份、五味子(酒制)10~20份、白花丹10~20份、降香5~10份、三七10~25份、桃仁(炒)15~20份、红花5~10份,优选重量份为:驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、降香6份、三七12份、桃仁(炒)20份、红花8份。 On the basis of the original formula, you can also add Jiangxiang, Panax notoginseng, peach kernel, and safflower. Meridian, dissipating blood stasis and relieving pain, the new sub-prescriptions are (parts by weight): 30-60 parts of vernonia anthelmintic, 30-60 parts of psoralen, 15-30 parts of angelica, 10-20 parts of schisandra (made from wine), 10-20 parts of white flower 10-20 parts of Dan, 5-10 parts of Jiangxiang, 10-25 parts of Panax notoginseng, 15-20 parts of peach kernel (stir-fried), 5-10 parts of safflower, the preferred parts by weight are: 36 parts of insect repellent Vernonia, Bugu 36 parts of fat, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plum blossom, 6 parts of jiangxiang, 12 parts of panax notoginseng, 20 parts of peach kernel (fried), and 8 parts of safflower.
在原有配方的基础上,还可以加入地黄、白薇、牡丹皮,地黄清热凉血、养阴生津,白薇清热凉血、解毒疗疮,牡丹皮清热凉血、活血化瘀,新的子方为(重量份):驱虫斑鸠菊30~60份、补骨脂30~60份、当归15~30份、五味子(酒制)10~20份、白花丹10~20份、地黄25~30份、白薇5~10份、牡丹皮15~30份,优选重量份为:驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、地黄28份、白薇8份、牡丹皮20份。 On the basis of the original formula, you can also add rehmannia glutinosa, Baiwei, and Moutan bark. Recipe (parts by weight): 30-60 parts of vernonia anthelmintic, 30-60 parts of psoralen, 15-30 parts of angelica, 10-20 parts of schisandra (wine), 10-20 parts of plumbago, 25-25 parts of rehmannia 30 parts, 5-10 parts of Baiwei, 15-30 parts of Moutan bark, the preferred parts by weight are: 36 parts of insect repellent Vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (made from wine), 12 parts of plum blossom 28 parts of Rehmannia glutinosa, 8 parts of Bai Wei, 20 parts of Moutan bark.
在原有配方的基础上,还可以加入菟丝子、女贞子、何首乌,菟丝子、女贞子补益肝肾,何首乌解毒消痈,新的子方为(重量份):驱虫斑鸠菊30~60份、补骨脂30~60份、当归15~30份、五味子(酒制)10~20份、白花丹10~20份、菟丝子20~30份、女贞子10~15份、何首乌15~25份,优选重量份为:驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、菟丝子25份、女贞子12份、何首乌20份。 On the basis of the original formula, Cuscuta, Ligustrum lucidum, and Polygonum multiflorum can also be added. Cuscuta, Privetrum privet can nourish the liver and kidney, Polygonum multiflorum detoxifies and eliminates carbuncles. The new formula is (parts by weight): 30 to 60 parts of vernium expelling insects , 30-60 parts of psoralen, 15-30 parts of angelica, 10-20 parts of schisandra (wine system), 10-20 parts of plum blossom, 20-30 parts of dodder, 10-15 parts of privet fruit, 15-25 parts of Polygonum multiflorum The preferred parts by weight are: 36 parts of Vernonia anthelminticus, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine system), 12 parts of plum flower, 25 parts of dodder, 12 parts of privet fruit, 20 parts of Polygonum multiflorum .
在原有配方的基础上,还可以加入盒果藤、乌梅、蒺藜,盒果藤(旋花科植物盒果藤Operculina turpethum(L.)S.Manso干燥根茎)利水消肿、舒筋活络,乌梅敛肺、涩肠、生津,蒺藜平肝解郁、活血祛风、明目止痒,新的子方为(重量份):驱虫斑鸠菊30~60份、补骨脂30~60份、当归15~30份、五味子(酒制)10~20份、白花丹10~20份、盒果藤12~20份、乌梅10~20份、蒺藜(炒)15~20份,优选重量份为:驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、盒果藤18份、乌梅15份、蒺藜(炒)18份。 On the basis of the original formula, you can also add Operculina turpethum, ebony, Tribulus terrestris, Operculina turpethum (L.) S.Manso dried rhizome) to promote water swelling, relax muscles and activate collaterals, and Operculina turpethum Constricting the lungs, astringent intestines, promoting body fluid, Tribulus terrestris calming the liver and relieving stagnation, promoting blood circulation and expelling wind, improving eyesight and relieving itching, the new sub-prescriptions are (parts by weight): 30-60 parts of Vernonia anthelmintic, 30-60 parts of psoralen, 15-30 parts of angelica, 10-20 parts of schisandra (wine system), 10-20 parts of plumbago, 12-20 parts of box fruit, 10-20 parts of black plum, 15-20 parts of tribulus (stir-fried), the preferred parts by weight are : Vernonia 36 parts, psoralen 36 parts, angelica 18 parts, schisandra (wine) 18 parts, plumflower 12 parts, box fruit 18 parts, ebony 15 parts, Tribulus terrestris (stir-fried) 18 parts.
由上可知,在原有配方的基础上加入不同的增效成分可以衍生出来多个子方,各子方均能起到治疗白癜风和银屑病的作用,且治疗效果在不同程度上有所提高。上述各子方中加入的各组增效成分还可以相互混合叠加使用,形成新的子方,例如,在原有配方的基础上可以同时加入降香、三七、桃仁(炒)、红花、地黄、白薇、牡丹皮成分,形成新的子方,其他增效成分也可进行混用。 It can be seen from the above that adding different synergistic ingredients on the basis of the original formula can derive multiple sub-prescriptions, each sub-prescription can play a role in treating vitiligo and psoriasis, and the therapeutic effect has been improved to varying degrees. The groups of synergistic ingredients added in the above sub-recipes can also be mixed and superimposed to form new sub-recipes. Rehmannia glutinosa, Bai Wei, and peony bark ingredients form a new sub-prescription, and other synergistic ingredients can also be mixed.
本发明的中药组合物可制成胶囊剂,也可以加入相应辅料制成片剂、丸剂、颗粒剂等。制备不同剂型仅所用的辅料不同,药物有效成分还是一样的,治疗效果也相同或近似。片剂的辅料为淀粉、微晶纤维素、预胶化淀粉、乳糖、羧甲淀粉钠、超级羧甲淀粉钠、低取代羟丙基纤维素、羟丙甲纤维素、滑石粉、硬脂酸镁;丸剂的辅料为淀粉、微晶纤维素、羧甲淀粉钠、羟丙甲纤维素;颗粒剂的辅料为庶糖粉、糊精;胶囊剂的辅料为淀粉、预胶化淀粉、微晶纤维素、羧甲淀粉钠、超级羧甲淀粉钠、羟丙甲纤维素、滑石粉、二氧化硅、硬脂酸镁。 The traditional Chinese medicine composition of the present invention can be made into capsules, and can also be made into tablets, pills, granules and the like by adding corresponding auxiliary materials. Only the excipients used in the preparation of different dosage forms are different, the active ingredients of the medicine are still the same, and the therapeutic effect is also the same or similar. Tablet excipients are starch, microcrystalline cellulose, pregelatinized starch, lactose, sodium starch glycolate, super sodium starch glycolate, low-substituted hydroxypropyl cellulose, hypromellose, talc, stearic acid Magnesium; auxiliary materials for pills are starch, microcrystalline cellulose, sodium starch glycolate, hypromellose; auxiliary materials for granules are sucrose powder, dextrin; auxiliary materials for capsules are starch, pregelatinized starch, microcrystalline cellulose Sodium Starch, Super Starch Sodium, Hypromellose, Talc, Silicon Dioxide, Magnesium Stearate.
中药组合物的制备方法,其特征是包括以下步骤: The preparation method of Chinese medicine composition is characterized in that comprising the following steps:
(1)将驱虫斑鸠菊粉碎成细粉,备用; (1) Crush the insect repellent Vernonia into fine powder and set aside;
(2)将剩余的原料药混合,用6~12质量倍的65~80vol%的乙醇提取2~3次,合并提取液; (2) Mix the remaining raw materials, extract 2 to 3 times with 65 to 80 vol% ethanol of 6 to 12 mass times, and combine the extracts;
(3)将提取液浓缩成60-80℃相对密度为1.20~1.40的清膏或稠膏; (3) Concentrate the extract into a clear or thick paste with a relative density of 1.20-1.40 at 60-80°C;
(4)将清膏、驱虫斑鸠菊细粉与药用量的辅料混合,制成所需剂型的中药组合物。 (4) Mix the clear ointment, the fine powder of Vernonia vernium and the medicinal amount of excipients to prepare a traditional Chinese medicine composition in the required dosage form.
上述步骤(2)中,2次提取时,每次2h;3次提取时,第一次2小时,第二次1小时,第二次1小时。 In the above step (2), for 2 extractions, each time is 2 hours; for 3 extractions, the first time is 2 hours, the second time is 1 hour, and the second time is 1 hour.
本发明制备简单,以驱虫斑鸠菊、补骨脂为主,辅以其他药物成分,具有活血凉血、祛风散寒、散瘀化瘀、杀虫疗癣的功效,从根本上解决了白癜风和银屑病发病原因,直除病灶,达到根治的目的。 The preparation of the present invention is simple, and it is mainly composed of vernium and psoralen, supplemented by other medicinal ingredients, and has the effects of promoting blood circulation and cooling blood, expelling wind and cold, dispelling blood stasis and removing blood stasis, killing insects and treating ringworm, and fundamentally solves the problem of The pathogenesis of vitiligo and psoriasis can be directly removed to achieve the goal of a radical cure.
具体实施方式 Detailed ways
下面结合具体实施例对本发明作进一步说明,应该明白的是,下述说明仅是为了解释本发明,并不对其内容进行限制。以下原料药用量若无特殊说明,均为重量份。 The present invention will be further described below in conjunction with specific embodiments. It should be understood that the following description is only for explaining the present invention, and does not limit its content. Unless otherwise specified, the amounts of the following raw materials are parts by weight.
实施例1Example 1
取驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份,按照下列方法制成胶囊剂: Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine) and 12 parts of plumbago, and make capsules according to the following method:
(1) 将驱虫斑鸠菊粉碎成细粉,备用; (1) Grind the insect repellent Vernonia into fine powder, set aside;
(2) 其余药材用8倍量75vol%的乙醇提取3次,第一次2小时,第二次1小时,第二次1小时,合并提取液,滤过,滤液浓缩至相对密度为1.20~1.30(70℃)的稠膏; (2) The rest of the medicinal materials are extracted 3 times with 8 times the amount of 75vol% ethanol, the first time is 2 hours, the second time is 1 hour, the second time is 1 hour, the extracts are combined, filtered, and the filtrate is concentrated to a relative density of 1.20~ 1.30 (70°C) thick paste;
(3) 将驱虫斑鸠菊细粉与上述稠膏混匀,干燥,得干膏; (3) Mix the insect repellent Vernonia fine powder with the above-mentioned thick paste, and dry to obtain a dry paste;
(4) 将干膏粉碎成细粉,加入适量药用辅料,混匀,制粒,干燥,加入1%的硬脂酸镁,混匀,装胶囊,即得,每粒装0.5g。 (4) Crush the dry paste into fine powder, add appropriate amount of pharmaceutical excipients, mix well, granulate, dry, add 1% magnesium stearate, mix well, pack into capsules, and get it, each capsule contains 0.5g.
实施例2Example 2
取驱虫斑鸠菊30份、补骨脂60份、当归15份、五味子(酒制)20份、白花丹10份,按照下列方法制成胶囊剂: Take 30 parts of vernonia, 60 parts of psoralen, 15 parts of angelica, 20 parts of schisandra (wine) and 10 parts of plumbago, and make capsules according to the following method:
(1) 将驱虫斑鸠菊粉碎成细粉,备用; (1) Grind the insect repellent Vernonia into fine powder, set aside;
(2) 其余药材用6倍量80vol%乙醇提取2次,每次2小时,合并提取液,滤过,滤液浓缩至相对密度为1.25~1.35(60℃)的稠膏; (2) The remaining medicinal materials were extracted twice with 6 times the amount of 80vol% ethanol, each time for 2 hours, the extracts were combined, filtered, and the filtrate was concentrated to a thick paste with a relative density of 1.25-1.35 (60°C);
(3) 将药材细粉与上述稠膏混匀,干燥,得干膏; (3) Mix the medicinal material fine powder with the above-mentioned thick ointment, and dry to obtain a dry ointment;
(4) 将干膏粉碎成细粉,加入适量药用辅料,混匀,制粒,干燥,加入0.5%的硬脂酸镁,混匀,装胶囊,即得,每粒装0.5g。 (4) Grind the dry paste into fine powder, add appropriate amount of pharmaceutical excipients, mix well, granulate, dry, add 0.5% magnesium stearate, mix well, pack into capsules, and get it, 0.5g per capsule.
实施例3Example 3
取驱虫斑鸠菊60份、补骨脂30份、当归30份、五味子(酒制)10份、白花丹20份,按照下列方法制成胶囊剂: Take 60 parts of vernonia, 30 parts of psoralen, 30 parts of angelica, 10 parts of schisandra (wine) and 20 parts of plumbago, and make capsules according to the following method:
(1) 将驱虫斑鸠菊粉碎成细粉,备用; (1) Grind the insect repellent Vernonia into fine powder, set aside;
(2) 其余药材用12倍量65vol%乙醇提取2次,每次2小时,合并提取液,滤过,滤液浓缩至相对密度为1.30~1.35(80℃)的稠膏; (2) The remaining medicinal materials were extracted twice with 12 times the amount of 65vol% ethanol, each time for 2 hours, the extracts were combined, filtered, and the filtrate was concentrated to a thick paste with a relative density of 1.30-1.35 (80°C);
(3) 将药材细粉与上述稠膏混匀,干燥,得干膏; (3) Mix the medicinal material fine powder with the above-mentioned thick ointment, and dry to obtain a dry ointment;
(4) 将干膏粉碎成细粉,加入适量药用辅料,混匀,制粒,干燥,加入0.8%的硬脂酸镁,混匀,装胶囊,即得,每粒装0.5g。 (4) Grind the dry paste into fine powder, add appropriate amount of pharmaceutical excipients, mix well, granulate, dry, add 0.8% magnesium stearate, mix well, pack into capsules, and get it, 0.5g per capsule.
实施例4Example 4
取驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、黄芪25份、川芎12份,按照下列方法制成胶囊剂: Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plumbago, 25 parts of astragalus, and 12 parts of chuanxiong, and make capsules according to the following method:
(1) 将驱虫斑鸠菊粉碎成细粉,备用; (1) Grind the insect repellent Vernonia into fine powder, set aside;
(2) 其余药材用10倍量70vol%乙醇提取2次,每次2小时,合并提取液,滤过,滤液浓缩至相对密度为1.25~1.35(75℃)的稠膏; (2) The remaining medicinal materials were extracted twice with 10 times the amount of 70vol% ethanol, each time for 2 hours, the extracts were combined, filtered, and the filtrate was concentrated to a thick paste with a relative density of 1.25-1.35 (75°C);
(3) 将药材细粉与上述稠膏混匀,干燥,得干膏; (3) Mix the medicinal material fine powder with the above-mentioned thick ointment, and dry to obtain a dry ointment;
(4) 将干膏粉碎成细粉,加入适量药用辅料,混匀,制粒,干燥,加入1.5%的硬脂酸镁,混匀,装胶囊,即得,每粒装0.5g。 (4) Grind the dry paste into fine powder, add appropriate amount of pharmaceutical excipients, mix well, granulate, dry, add 1.5% magnesium stearate, mix well, pack into capsules, and get it, each capsule contains 0.5g.
实施例5Example 5
取驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、拳参10份、防风10份、川芎12份、粉萆薢20份,按照下列方法制成胶囊剂: Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plum blossom, 10 parts of ginseng, 10 parts of wind, 12 parts of chuanxiong, 20 parts of fennel, according to Capsules are prepared in the following ways:
(1) 将驱虫斑鸠菊粉碎成细粉,备用; (1) Grind the insect repellent Vernonia into fine powder, set aside;
(2) 其余药材用8倍量80vol%乙醇提取2次,每次2小时,合并提取液,滤过,滤液浓缩至相对密度为1.20~1.25(80℃)的清膏; (2) The remaining medicinal materials were extracted twice with 8 times the amount of 80vol% ethanol, each time for 2 hours, the extracts were combined, filtered, and the filtrate was concentrated to a clear paste with a relative density of 1.20-1.25 (80°C);
(3) 将药材细粉与上述清膏在沸腾干燥制粒机中一步制粒,干燥,加入0.8%的硬脂酸镁,混匀,装胶囊,即得,每粒装0.5g。 (3) The fine powder of the medicinal material and the above-mentioned clear paste are granulated in a boiling drying granulator in one step, dried, added 0.8% magnesium stearate, mixed evenly, and packed into capsules.
实施例6Example 6
取驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、高良姜18份、白芷25份、地肤子15份,按照实施例1的方法制成胶囊。 Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plumbago, 18 parts of galangal, 25 parts of angelica, 15 parts of Kochia scoparia, according to Example 1 The method is made into capsules.
实施例7Example 7
取驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、牡蛎10份,按照实施例2的方法制成胶囊。 Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plumbago, and 10 parts of oyster, and make capsules according to the method in Example 2.
实施例8Example 8
取驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、土茯苓35份、白鲜皮15份、蒲公英22份、马齿苋15份,按照实施例3的方法制成胶囊。 Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine system), 12 parts of plum flower dan, 35 parts of Smilax smilax, 15 parts of white fresh skin, 22 parts of dandelion, 15 parts of purslane Parts are made into capsules according to the method of Example 3.
实施例9Example 9
取驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、降香6份、三七12份、桃仁(炒)20份、红花8份,按照实施例4的方法制成胶囊。 Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine system), 12 parts of plum blossom, 6 parts of Jiangxiang, 12 parts of Panax notoginseng, 20 parts of peach kernel (stir-fried), safflower 8 parts, make capsule according to the method for embodiment 4.
实施例10Example 10
取驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、地黄28份、白薇8份、牡丹皮20份,按照实施例5的方法制成胶囊。 Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine system), 12 parts of plumflower dan, 28 parts of rehmannia glutinosa, 8 parts of Baiwei, 20 parts of Moutan bark, according to the method of Example 5 Method made into capsules.
实施例11Example 11
取驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、菟丝子25份、女贞子12份、何首乌20份,按照实施例1的方法制成胶囊。 Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plum blossom, 25 parts of dodder, 12 parts of privet fruit, 20 parts of Polygonum multiflorum, according to the method of Example 1 Method made into capsules.
实施例12Example 12
取驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、盒果藤18份、乌梅15份、蒺藜(炒)18份,按照实施例1的方法制成胶囊。 Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plum flower, 18 parts of box fruit, 15 parts of ebony, 18 parts of tribulus (fried), according to the implementation The method of example 1 is made capsule.
实施例13Example 13
取驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、拳参10份、防风10份、川芎12份、粉萆薢20份、地黄28份、白薇8份、牡丹皮20份,按照实施例3的方法制成胶囊。 Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plumbago, 10 parts of ginseng, 10 parts of wind, 12 parts of Chuanxiong, 20 parts of fennel, rehmannia glutinosa 28 parts, 8 parts of Bai Wei, 20 parts of Cortex Moutan, are made into capsules according to the method of Example 3.
实施例14Example 14
取驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、土茯苓35份、白鲜皮15份、蒲公英22份、马齿苋15份、菟丝子25份、女贞子12份、何首乌20份、牡蛎10份,按照实施例2的方法制成胶囊。 Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine system), 12 parts of plum flower dan, 35 parts of Smilax smilax, 15 parts of white fresh skin, 22 parts of dandelion, 15 parts of purslane 25 parts, 25 parts of Dodder, 12 parts of Ligustrum lucidum, 20 parts of Radix Polygoni Multiflori, 10 parts of oysters, capsules are made according to the method of Example 2.
实施例15Example 15
取驱虫斑鸠菊60份、补骨脂30份、当归30份、五味子(酒制)10份、白花丹20份、拳参8份、防风18份、川芎9份、粉萆薢32份,按照实施例1的方法制成胶囊。 Take 60 parts of vernonia, 30 parts of psoraleae, 30 parts of angelica, 10 parts of schisandra (wine), 20 parts of plumflower dan, 8 parts of ginseng, 18 parts of wind, 9 parts of chuanxiong, 32 parts of fennel, according to The method of embodiment 1 is made capsule.
实施例16Example 16
取驱虫斑鸠菊30份、补骨脂60份、当归15份、五味子(酒制)20份、白花丹10份、拳参20份、防风9份、川芎18份、粉萆薢16份,按照实施例1的方法制成胶囊。 Take 30 parts of vernonia, 60 parts of psoralen, 15 parts of angelica, 20 parts of schisandra (wine), 10 parts of plumflower dan, 20 parts of fist ginseng, 9 parts of windproof, 18 parts of chuanxiong, 16 parts of fennel, according to The method of embodiment 1 is made capsule.
实施例17Example 17
取驱虫斑鸠菊60份、补骨脂30份、当归30份、五味子(酒制)10份、白花丹20份、黄芪40份、川芎9份,按照实施例2的方法制成胶囊。 Take 60 parts of vernonia, 30 parts of psoraleae, 30 parts of angelica, 10 parts of schisandra (made from wine), 20 parts of plumbago, 40 parts of astragalus, and 9 parts of chuanxiong, and make capsules according to the method in Example 2.
实施例18Example 18
取驱虫斑鸠菊30份、补骨脂60份、当归15份、五味子(酒制)20份、白花丹10份、高良姜5份、白芷30份、地肤子10份,按照实施例4的方法制成胶囊。 Take 30 parts of vernonia, 60 parts of psoralen, 15 parts of angelica, 20 parts of schisandra (wine), 10 parts of plum flower, 5 parts of galangal, 30 parts of angelica, 10 parts of Kochia scoparia, according to Example 4 The method is made into capsules.
实施例19Example 19
取驱虫斑鸠菊60份、补骨脂30份、当归30份、五味子(酒制)10份、白花丹20份、高良姜30份、白芷20份、地肤子20份,按照下列方法制成胶囊剂。 Take 60 parts of vernonia, 30 parts of psoralen, 30 parts of angelica, 10 parts of schisandra (wine), 20 parts of plumbago, 30 parts of galangal, 20 parts of angelica dahurica, 20 parts of Kochia scoparia, and make according to the following method into capsules.
实施例20Example 20
取驱虫斑鸠菊60份、补骨脂30份、当归30份、五味子(酒制)10份、白花丹20份、牡蛎5份、降香10份、三七25份、桃仁(炒)15份、红花5份,按照实施例5的方法制成胶囊。 Take 60 parts of vernonia, 30 parts of psoralen, 30 parts of angelica, 10 parts of schisandra (wine), 20 parts of plum blossom, 5 parts of oyster, 10 parts of Jiangxiang, 25 parts of Panax notoginseng, 15 parts of peach kernel (stir-fried) 5 parts, 5 parts of safflower, capsules are made according to the method for embodiment 5.
实施例21Example 21
取驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、盒果藤12份、乌梅20份、蒺藜(炒)15份,按照实施例4的方法制成胶囊。 Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plum flower, 12 parts of box fruit, 20 parts of ebony, 15 parts of tribulus (fried), according to the implementation The method of example 4 is made capsule.
实施例22Example 22
取驱虫斑鸠菊36份、补骨脂36份、当归18份、五味子(酒制)18份、白花丹12份、菟丝子30份、女贞子10份、何首乌25份,按照实施例4的方法制成胶囊。 Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plum flower, 30 parts of dodder, 10 parts of privet fruit, 25 parts of Polygonum multiflorum, according to the method of embodiment 4 Method made into capsules.
实施例23Example 23
取驱虫斑鸠菊30份、补骨脂60份、当归15份、五味子(酒制)20份、白花丹10份、地黄25份、白薇10份、牡丹皮15份、盒果藤20份、乌梅10份、蒺藜(炒)10份,按照实施例3的方法制成胶囊。 Take 30 parts of vernonia, 60 parts of psoralen, 15 parts of angelica, 20 parts of schisandra (wine), 10 parts of plum blossom, 25 parts of rehmannia glutinosa, 10 parts of Baiwei, 15 parts of peony bark, and 20 parts of box fruit vine , 10 parts of ebony plums, 10 parts of Tribulus terrestris (fried), make capsules according to the method of embodiment 3.
实施例24Example 24
取驱虫斑鸠菊30份、补骨脂60份、当归15份、五味子(酒制)20份、白花丹10份、高良姜5份、白芷30份、地肤子10份、牡蛎30份、降香5份、三七10份、桃仁(炒)20份、红花10份,按照实施例1的方法制成胶囊。 Take 30 parts of vernonia, 60 parts of psoralen, 15 parts of angelica, 20 parts of schisandra (wine), 10 parts of plum flower, 5 parts of galangal, 30 parts of angelica, 10 parts of Kochia chinensis, 30 parts of oyster, 5 parts of Jiangxiang, 10 parts of Panax notoginseng, 20 parts of peach kernel (stir-fried), and 10 parts of safflower are made into capsules according to the method of Example 1.
除了上述实施例中的组合物外,本领域技术人员还可以根据上述描述得到其他原料组成的配方,上述实施例并非对本发明内容进行限制。另外,除了按照常规方法将组合物制成胶囊剂外,还可以根据现有技术中公开的常规方法将本发明组合物制成片剂、丸剂、颗粒剂。 In addition to the compositions in the above examples, those skilled in the art can also obtain formulas composed of other raw materials according to the above description, and the above examples do not limit the content of the present invention. In addition, in addition to making the composition into capsules according to conventional methods, the composition of the present invention can also be prepared into tablets, pills, and granules according to conventional methods disclosed in the prior art.
本发明的组合物无毒副作用,能够根治白癜风和银屑病,且治疗周期短,起效快,下面对本发明药物进行临床实验,证明其效果。 The composition of the invention has no toxic and side effects, can radically cure vitiligo and psoriasis, and has short treatment period and rapid onset of effect. The following clinical experiments are carried out on the medicine of the invention to prove its effect.
一、治疗白癜风临床实验1. Clinical trials for the treatment of vitiligo
1、病例来源 1. Case source
在本市各大皮肤病科选取600例白癜风患者,其中男330例,女270例;年龄15~53岁,平均26.8岁;病程2个月~18年,平均病程2.0年;进展期190例,稳定期410例。其诊断均符合全国中西医结合皮肤性病学会色素病学制定的诊断标准。 600 cases of vitiligo patients were selected from major dermatology departments in this city, including 330 males and 270 females; aged 15 to 53 years, with an average of 26.8 years; the course of the disease was 2 months to 18 years, with an average course of 2.0 years; 190 cases in the advanced stage , 410 cases in the stable period. The diagnosis was in line with the diagnostic criteria established by the National Society of Dermatology and Venereology of Integrated Traditional Chinese and Western Medicine.
2、试验方法 2. Test method
将患者平均分为10组,各组无统计学差异,每组患者分别使用本发明实施例的药物,每日3次,每次2粒,四周为一个疗程,连续服用3个月。 Patient is divided into 10 groups on average, each group has no statistical difference, each group of patients uses the medicine of the embodiment of the present invention respectively, every day 3 times, each 2 capsules, four weeks is a course of treatment, takes 3 months continuously.
3、疗效标准 3. Curative effect standard
显效:白斑部分消退或缩小,恢复正常肤色的面积占皮损面积≥50%; Significantly effective: the leukoplakia part fades or shrinks, and the area of returning to normal skin color accounts for ≥50% of the skin lesion area;
有效:白斑部分消退或缩小,恢复正常肤色的面积占皮损面积≥10%且<50%; Effective: the leukoplakia part disappears or shrinks, and the area of returning to normal skin color accounts for ≥10% and <50% of the lesion area;
无效:白斑恢复正常肤色的面积占皮损面积<10%。 Ineffective: the area where the white spots return to normal skin color accounts for <10% of the skin lesion area.
4、治疗结果 各组患者治疗情况见下表1。 4. Treatment results The treatment conditions of patients in each group are shown in Table 1 below.
二、治疗银屑病临床实验2. Clinical trials for the treatment of psoriasis
1、病例来源 1. Case source
选择门诊银屑病患者522例,其中男302例,女220例;年龄20~65岁,平均(40.5±10.8)岁;病程3月~18年,平均(12.4±6.9) 年;所有患者均符合寻常性银屑病诊断标准,银屑病面积严重度评分(PASI)均大于1O分。 A total of 522 outpatients with psoriasis were selected, including 302 males and 220 females; aged 20 to 65 years, with an average of (40.5±10.8) years; the course of disease was 3 months to 18 years, with an average of (12.4±6.9) years; all patients had Meet the diagnostic criteria for psoriasis vulgaris, and the psoriasis area severity score (PASI) is greater than 10 points.
2、试验方法 2. Test method
将患者平均分为9组,组间患者性别、年龄、病程、PASI评分差异均无统计学差异(P>0.05),具有可比性,每组患者分别使用本发明实施例的药物,每日3次,每次2粒,四周为一个疗程,连续服用3个月。 The patient is divided into 9 groups on average, and there is no statistical difference in gender, age, course of disease, and PASI score difference between groups (P>0.05), which is comparable, and each group of patients uses the medicine of the embodiment of the present invention respectively, every day 3 Time, 2 capsules each time, four weeks as a course of treatment, taking continuously for 3 months.
3、疗效标准 3. Curative effect standard
以银屑病的皮肤损伤面积与银屑病严重度评分(PASI)作为标准,对患者的临床症状与体征(鳞屑、浸润、红斑)进行评价,PASI下降指数为治疗前后评分的差值与治疗前评分的百分比值。以PASI评分下降指数做为疗效判定的依据。 The skin lesion area of psoriasis and the psoriasis severity score (PASI) were used as the standard to evaluate the clinical symptoms and signs (squamous, infiltrated, erythema) of the patients. The percentage value of the previous rating. The PASI score reduction index was used as the basis for judging the curative effect.
显效:PASI评分下降指数在60%以上; Significantly effective : PASI score reduction index is above 60%;
有效:PASI评分下降指数为30%~59%; Effective : PASI score decline index is 30% to 59%;
无效:PASI评分下降指数小于30%。 Invalid : PASI score decline index is less than 30%.
4、治疗结果 4. Treatment results
各组患者治疗情况见下表2。 The treatment status of the patients in each group is shown in Table 2 below.
上述白癜风和银屑病患者在治疗时绝大多数表现出很好的效果,且起效快,经过进一步的服用本药物,患者基本治愈,且在服用药物期间,无不良反应产生,说明本发明药物对人体基本无毒副作用。上述患者继续服用本发明药物,大部分患者在7-12个疗程痊愈,且跟踪调查显示,痊愈患者在2年内的复发率低于3%。 Most of the above-mentioned patients with vitiligo and psoriasis show good results during treatment, and the onset of effect is fast. After further taking this medicine, the patient is basically cured, and during the period of taking the medicine, no adverse reactions occur, which illustrates the present invention. Drugs have basically no toxic side effects on the human body. Above-mentioned patients continue to take medicine of the present invention, and most patients recover from illness after 7-12 courses of treatment, and follow-up survey shows, the recurrence rate of recovery from illness patients within 2 years is lower than 3%.
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CN106063870A (en) * | 2016-08-17 | 2016-11-02 | 施泽晶 | A kind of Chinese medicine composition treating damp abundance due to splenic asthenia type dermatitis and preparation method thereof |
CN117618318A (en) * | 2023-12-07 | 2024-03-01 | 广东尤发生物科技有限公司 | Disposable massage cream and preparation method thereof |
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Cited By (5)
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CN103461611A (en) * | 2013-10-09 | 2013-12-25 | 北京绿源求证科技发展有限责任公司 | Food health tea infusion dissolved medicine for improving vitiligo |
CN103830379A (en) * | 2014-03-03 | 2014-06-04 | 新疆吐鲁番地区维吾尔医医院 | Blood purifying mixture for treating skin diseases |
CN106063870A (en) * | 2016-08-17 | 2016-11-02 | 施泽晶 | A kind of Chinese medicine composition treating damp abundance due to splenic asthenia type dermatitis and preparation method thereof |
CN117618318A (en) * | 2023-12-07 | 2024-03-01 | 广东尤发生物科技有限公司 | Disposable massage cream and preparation method thereof |
CN117618318B (en) * | 2023-12-07 | 2024-05-24 | 广东尤发生物科技有限公司 | Disposable massage cream and preparation method thereof |
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