CN102908391A - Chinese medicinal composition for treating dermatosis and preparation method and application thereof - Google Patents

Abstract

The invention discloses a Chinese medicinal composition for treating dermatosis. The Chinese medicinal composition comprises the following raw materials in parts by weight: 30-60 parts of vernonia anthelmintica, 30-60 parts of malaytea scurfpea fruit, 15-30 parts of Chinese angelica, 10-20 parts of Chinese magnoliavine fruit (alcohol-treated) and 10-20 parts of plumbago zeylanica. The invention further provides a preparation method and an application of the Chinese medicinal composition. The medicament is easy to prepare, is prepared from vernonia anthelmintica and malaytea scurfpea fruit serving as major raw materials and other medicinal components, and has the effects of activating blood, cooling blood, expelling wind, clearing away cold, dissipating blood stasis, killing parasites and curing ringworms; and pathogenesis of vitligo and psoriasis are eliminated fundamentally, focuses of infection are eliminated directly, and the aim of curing is fulfilled.

Description

A traditional Chinese medicine composition for treating skin diseases and its preparation method and application

technical field

The invention relates to a medicine for treating skin diseases, in particular to a traditional Chinese medicine composition for treating vitiligo and psoriasis, and belongs to the technical field of medicine.

Background technique

Vitiligo (vitiligo) is an acquired depigmentation skin disease, clinically manifested as depigmentation spots of different sizes and shapes, the number is indefinite, the edges are clear, and some of the normal skin around the leukoplakia increases in pigment. Vitiligo can occur in any part of the body, but it is more common in exposed parts such as the face, neck, back of the hand, and skin in the folds of the external genitalia. Exposure of the leukoplakia to visible parts will affect the appearance of the patient, and in turn affect the appearance of the patient. The normal life of the patient causes a lot of psychological pressure, so there are many people seeking treatment, and they are all urgent.

Psoriasis, commonly known as psoriasis, has a high incidence rate and a long course of disease. The pathogenesis involves genetic immunity, inflammatory mediators, nerve mediators, cell proliferation and apoptosis, and microcirculation disorders. Patients with psoriasis can be found all over the world, and can occur in different ethnic groups, genders, and ages. According to domestic literature reports, the incidence of psoriasis patients in my country accounts for about 0.5% to 2% of the total population, and about 10% to 30% of psoriasis patients have family history. Healing, high recurrence rate and other reasons seriously affect the social life of patients, causing great physical and psychological pain. At the same time, due to the recurrent outbreak of the disease, repeated treatment is often required, which also brings a heavy economic burden to the patient.

Nowadays, there are many medicines for treating vitiligo and psoriasis, both traditional Chinese medicine and western medicine. Although they can all play a certain role, they cannot be cured, and they are easy to relapse and have strong drug dependence. How to treat vitiligo and psoriasis has become a major problem in the field of medicine in the world, and it is one of the diseases that are mainly researched and prevented in the field of skin at home and abroad.

Contents of the invention

In order to overcome the shortcomings of the prior art, the invention provides a traditional Chinese medicine composition for treating skin diseases, which has the advantages of high stability and good therapeutic effect on vitiligo and psoriasis.

The invention also discloses a preparation method and application of the composition, which has simple preparation, remarkable curative effect and is convenient for large-scale industrial application.

The present invention is achieved through the following technical solutions:

A traditional Chinese medicine composition for treating skin diseases, comprising the following raw materials in parts by weight: 30-60 parts of vernonia anthelmintic, 30-60 parts of psoralen, 15-30 parts of angelica, 10-20 parts of schisandra (made from wine), 10-20 parts of plum blossom.

The above traditional Chinese medicine composition preferably includes the following raw materials in parts by weight: 36 parts of Vernonia anthelminticus, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (made from wine), and 12 parts of plumbago.

The main formula raw materials of the present invention are anthelmintic vernonia, psoralen, angelica, schisandra, plumbago, and the efficacy of each raw material is as follows:

Vernonia anthelmintica, the ripe fruit of Vernonia anthelmintica Willd, a plant of Compositae. The fruit is harvested in autumn and dried in the sun. Mainly produced in Kashgar and Aksu areas of Xinjiang, Uighur name Atrila, has the functions of clearing away heat and reducing inflammation, promoting blood circulation and removing blood stasis, and killing insects, and is used to treat skin diseases.

Psoralea, leguminous plant Psoralea corylifolia L. The dried and mature fruit of the herb has the functions of warming the kidney and supporting yang, inducing Qi to relieve asthma, and dampening the spleen to relieve diarrhea. It is used for deficiency of kidney yang, impotence and nocturnal emission, enuresis, frequent urination, cold pain in the waist and knees, asthma caused by kidney deficiency, and diarrhea at dawn. External use Cure vitiligo, alopecia areata.

Angelica sinensis, the dried root of Angelica sinensis (Oliv.) Diels, a Umbelliferae plant, has the functions of nourishing blood and promoting blood circulation, regulating menstruation, relieving pain, and laxative. Cold abdominal pain, rheumatic arthralgia, injury from falling, carbuncle sores, intestinal dryness and constipation.

Schisandra chinensis, the dried and mature fruit of Schisandra chinensis (Turcz.) Baill. , enuresis, frequent urination, chronic diarrhea, spontaneous sweating, thirsty wounds, internal heat and thirst, palpitations and insomnia.

Plumbago zeylanis, Plumbago zeylanis L. The dry stems and branches without leaves of Plumbago zeylanis L. can be harvested throughout the year. It has the functions of dispelling wind and blood stasis, detoxifying and killing insects.

The present invention mainly uses vernonia and psoralen as the main ingredients, supplemented by other medicinal ingredients, promotes blood circulation and cools blood, dispels wind and cold, dissipates blood stasis and removes blood stasis, kills insects and treats ringworm, and fundamentally solves the problems of vitiligo and psoriasis. The cause of the disease is directly removed from the focus to achieve the purpose of a radical cure.

On the basis of the original formula, some other synergistic raw materials can also be added to enhance the curative effect. For example, astragalus and chuanxiong can be further added to play the role of dispelling blood stasis and supporting poison, invigorating qi and strengthening the surface. The new formula formed is (parts by weight) : 30-60 parts of vernonia, 30-60 parts of psoralen, 15-30 parts of angelica, 10-20 parts of schisandra (wine), 10-20 parts of plumbago, 10-40 parts of astragalus, 9-40 parts of chuanxiong 18 parts, the preferred parts by weight are: 36 parts of Vernonia anthelminticus, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plumbago, 25 parts of astragalus, and 12 parts of chuanxiong.

On the basis of the original formula, you can also add boxing ginseng, Fangfeng, Chuanxiong, and Fenxiong to form a new sub-prescription. Wind relieves pain, Fenji scorpion promotes dampness and removes turbidity, dispels wind and eliminates numbness, the new sub-prescriptions are (parts by weight): 30-60 parts of vernonia anthelmintic, 30-60 parts of psoralen, 15-30 parts of angelica, schisandra ( Liquor system) 10-20 parts, Plumbago 10-20 parts, ginseng 8-20 parts, Fangfeng 9-18 parts, Chuanxiong 9-18 parts, fennel 16-32 parts, the preferred parts by weight are: insect repellent Vernonia 36 parts, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plum blossom, 10 parts of boxing ginseng, 10 parts of Fangfeng, 12 parts of Chuanxiong, and 20 parts of fennel.

On the basis of the original formula, galangal, angelica dahurica and Kochia scoparia can be added to form a new sub-prescription. Kochia chinensis clears away heat and promotes dampness, dispels wind and relieves itching, and the new sub-prescriptions are (parts by weight): 30-60 parts of Vernonia anthelminticus, 30-60 parts of psoralen, 15-30 parts of angelica, schisandra (wine) 10-20 parts, Plumbago 10-20 parts, Galangal 5-30 parts, Angelica dahurica 20-30 parts, Kochia scoparia 10-20 parts, the preferred parts by weight are: Vernonia 36 parts, Psoralen psoraleae 36 parts , 18 parts of angelica, 18 parts of schisandra (wine system), 12 parts of plumbago, 18 parts of galangal, 25 parts of angelica, 15 parts of Kochia scoparia.

On the basis of the original formula, oysters can also be added. Oysters have the effects of suppressing yang and nourishing yin, softening and resolving stagnation, and can also supplement trace elements. 30-60 parts of psoralen, 15-30 parts of angelica, 10-20 parts of schisandra (wine system), 10-20 parts of plumbago, 5-30 parts of oyster, the preferred parts by weight are: 36 parts of repellent vernonia, 36 parts of bone fat, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plum blossom, 10 parts of oyster.

On the basis of the original formula, you can also add Smilax smilax glabra Roxb., Smilax glabra Roxb. Mountain dragon has the effect of detoxification and dehumidification, white fresh skin has the effect of clearing heat and dampness, dispelling wind and detoxification, dandelion has the effect of clearing heat and detoxification, reducing swelling and dispelling stagnation, purslane has the effect of clearing heat and detoxification, cooling blood and stopping bleeding, new The sub-prescriptions are (parts by weight): 30-60 parts of vernonia anthelmintic, 30-60 parts of psoralen, 15-30 parts of angelica, 10-20 parts of schisandra (wine), 10-20 parts of plumbago, smilax smilax 30-40 parts, 10-25 parts of white fresh skin, 20-25 parts of dandelion, 10-20 parts of purslane, the preferred parts by weight are: 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, schisandra (Wine system) 18 parts, plum flower 12 parts, smilax 35 parts, white fresh skin 15 parts, dandelion 22 parts, purslane 15 parts.

On the basis of the original formula, you can also add Jiangxiang, Panax notoginseng, peach kernel, and safflower. Meridian, dissipating blood stasis and relieving pain, the new sub-prescriptions are (parts by weight): 30-60 parts of vernonia anthelmintic, 30-60 parts of psoralen, 15-30 parts of angelica, 10-20 parts of schisandra (made from wine), 10-20 parts of white flower 10-20 parts of Dan, 5-10 parts of Jiangxiang, 10-25 parts of Panax notoginseng, 15-20 parts of peach kernel (stir-fried), 5-10 parts of safflower, the preferred parts by weight are: 36 parts of insect repellent Vernonia, Bugu 36 parts of fat, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plum blossom, 6 parts of jiangxiang, 12 parts of panax notoginseng, 20 parts of peach kernel (fried), and 8 parts of safflower.

On the basis of the original formula, you can also add rehmannia glutinosa, Baiwei, and Moutan bark. Recipe (parts by weight): 30-60 parts of vernonia anthelmintic, 30-60 parts of psoralen, 15-30 parts of angelica, 10-20 parts of schisandra (wine), 10-20 parts of plumbago, 25-25 parts of rehmannia 30 parts, 5-10 parts of Baiwei, 15-30 parts of Moutan bark, the preferred parts by weight are: 36 parts of insect repellent Vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (made from wine), 12 parts of plum blossom 28 parts of Rehmannia glutinosa, 8 parts of Bai Wei, 20 parts of Moutan bark.

On the basis of the original formula, Cuscuta, Ligustrum lucidum, and Polygonum multiflorum can also be added. Cuscuta, Privetrum privet can nourish the liver and kidney, Polygonum multiflorum detoxifies and eliminates carbuncles. The new formula is (parts by weight): 30 to 60 parts of vernium expelling insects , 30-60 parts of psoralen, 15-30 parts of angelica, 10-20 parts of schisandra (wine system), 10-20 parts of plum blossom, 20-30 parts of dodder, 10-15 parts of privet fruit, 15-25 parts of Polygonum multiflorum The preferred parts by weight are: 36 parts of Vernonia anthelminticus, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine system), 12 parts of plum flower, 25 parts of dodder, 12 parts of privet fruit, 20 parts of Polygonum multiflorum .

On the basis of the original formula, you can also add Operculina turpethum, ebony, Tribulus terrestris, Operculina turpethum (L.) S.Manso dried rhizome) to promote water swelling, relax muscles and activate collaterals, and Operculina turpethum Constricting the lungs, astringent intestines, promoting body fluid, Tribulus terrestris calming the liver and relieving stagnation, promoting blood circulation and expelling wind, improving eyesight and relieving itching, the new sub-prescriptions are (parts by weight): 30-60 parts of Vernonia anthelmintic, 30-60 parts of psoralen, 15-30 parts of angelica, 10-20 parts of schisandra (wine system), 10-20 parts of plumbago, 12-20 parts of box fruit, 10-20 parts of black plum, 15-20 parts of tribulus (stir-fried), the preferred parts by weight are : Vernonia 36 parts, psoralen 36 parts, angelica 18 parts, schisandra (wine) 18 parts, plumflower 12 parts, box fruit 18 parts, ebony 15 parts, Tribulus terrestris (stir-fried) 18 parts.

It can be seen from the above that adding different synergistic ingredients on the basis of the original formula can derive multiple sub-prescriptions, each sub-prescription can play a role in treating vitiligo and psoriasis, and the therapeutic effect has been improved to varying degrees. The groups of synergistic ingredients added in the above sub-recipes can also be mixed and superimposed to form new sub-recipes. Rehmannia glutinosa, Bai Wei, and peony bark ingredients form a new sub-prescription, and other synergistic ingredients can also be mixed.

The traditional Chinese medicine composition of the present invention can be made into capsules, and can also be made into tablets, pills, granules and the like by adding corresponding auxiliary materials. Only the excipients used in the preparation of different dosage forms are different, the active ingredients of the medicine are still the same, and the therapeutic effect is also the same or similar. Tablet excipients are starch, microcrystalline cellulose, pregelatinized starch, lactose, sodium starch glycolate, super sodium starch glycolate, low-substituted hydroxypropyl cellulose, hypromellose, talc, stearic acid Magnesium; auxiliary materials for pills are starch, microcrystalline cellulose, sodium starch glycolate, hypromellose; auxiliary materials for granules are sucrose powder, dextrin; auxiliary materials for capsules are starch, pregelatinized starch, microcrystalline cellulose Sodium Starch, Super Starch Sodium, Hypromellose, Talc, Silicon Dioxide, Magnesium Stearate.

The preparation method of Chinese medicine composition is characterized in that comprising the following steps:

(1) Crush the insect repellent Vernonia into fine powder and set aside;

(2) Mix the remaining raw materials, extract 2 to 3 times with 65 to 80 vol% ethanol of 6 to 12 mass times, and combine the extracts;

(3) Concentrate the extract into a clear or thick paste with a relative density of 1.20-1.40 at 60-80°C;

(4) Mix the clear ointment, the fine powder of Vernonia vernium and the medicinal amount of excipients to prepare a traditional Chinese medicine composition in the required dosage form.

In the above step (2), for 2 extractions, each time is 2 hours; for 3 extractions, the first time is 2 hours, the second time is 1 hour, and the second time is 1 hour.

The preparation of the present invention is simple, and it is mainly composed of vernium and psoralen, supplemented by other medicinal ingredients, and has the effects of promoting blood circulation and cooling blood, expelling wind and cold, dispelling blood stasis and removing blood stasis, killing insects and treating ringworm, and fundamentally solves the problem of The pathogenesis of vitiligo and psoriasis can be directly removed to achieve the goal of a radical cure.

Detailed ways

The present invention will be further described below in conjunction with specific embodiments. It should be understood that the following description is only for explaining the present invention, and does not limit its content. Unless otherwise specified, the amounts of the following raw materials are parts by weight.

Example 1

Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine) and 12 parts of plumbago, and make capsules according to the following method:

(1) Grind the insect repellent Vernonia into fine powder, set aside;

(2) The rest of the medicinal materials are extracted 3 times with 8 times the amount of 75vol% ethanol, the first time is 2 hours, the second time is 1 hour, the second time is 1 hour, the extracts are combined, filtered, and the filtrate is concentrated to a relative density of 1.20~ 1.30 (70°C) thick paste;

(3) Mix the insect repellent Vernonia fine powder with the above-mentioned thick paste, and dry to obtain a dry paste;

(4) Crush the dry paste into fine powder, add appropriate amount of pharmaceutical excipients, mix well, granulate, dry, add 1% magnesium stearate, mix well, pack into capsules, and get it, each capsule contains 0.5g.

Example 2

Take 30 parts of vernonia, 60 parts of psoralen, 15 parts of angelica, 20 parts of schisandra (wine) and 10 parts of plumbago, and make capsules according to the following method:

(1) Grind the insect repellent Vernonia into fine powder, set aside;

(2) The remaining medicinal materials were extracted twice with 6 times the amount of 80vol% ethanol, each time for 2 hours, the extracts were combined, filtered, and the filtrate was concentrated to a thick paste with a relative density of 1.25-1.35 (60°C);

(3) Mix the medicinal material fine powder with the above-mentioned thick ointment, and dry to obtain a dry ointment;

(4) Grind the dry paste into fine powder, add appropriate amount of pharmaceutical excipients, mix well, granulate, dry, add 0.5% magnesium stearate, mix well, pack into capsules, and get it, 0.5g per capsule.

Example 3

Take 60 parts of vernonia, 30 parts of psoralen, 30 parts of angelica, 10 parts of schisandra (wine) and 20 parts of plumbago, and make capsules according to the following method:

(1) Grind the insect repellent Vernonia into fine powder, set aside;

(2) The remaining medicinal materials were extracted twice with 12 times the amount of 65vol% ethanol, each time for 2 hours, the extracts were combined, filtered, and the filtrate was concentrated to a thick paste with a relative density of 1.30-1.35 (80°C);

(3) Mix the medicinal material fine powder with the above-mentioned thick ointment, and dry to obtain a dry ointment;

(4) Grind the dry paste into fine powder, add appropriate amount of pharmaceutical excipients, mix well, granulate, dry, add 0.8% magnesium stearate, mix well, pack into capsules, and get it, 0.5g per capsule.

Example 4

Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plumbago, 25 parts of astragalus, and 12 parts of chuanxiong, and make capsules according to the following method:

(1) Grind the insect repellent Vernonia into fine powder, set aside;

(2) The remaining medicinal materials were extracted twice with 10 times the amount of 70vol% ethanol, each time for 2 hours, the extracts were combined, filtered, and the filtrate was concentrated to a thick paste with a relative density of 1.25-1.35 (75°C);

(3) Mix the medicinal material fine powder with the above-mentioned thick ointment, and dry to obtain a dry ointment;

(4) Grind the dry paste into fine powder, add appropriate amount of pharmaceutical excipients, mix well, granulate, dry, add 1.5% magnesium stearate, mix well, pack into capsules, and get it, each capsule contains 0.5g.

Example 5

Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plum blossom, 10 parts of ginseng, 10 parts of wind, 12 parts of chuanxiong, 20 parts of fennel, according to Capsules are prepared in the following ways:

(1) Grind the insect repellent Vernonia into fine powder, set aside;

(2) The remaining medicinal materials were extracted twice with 8 times the amount of 80vol% ethanol, each time for 2 hours, the extracts were combined, filtered, and the filtrate was concentrated to a clear paste with a relative density of 1.20-1.25 (80°C);

(3) The fine powder of the medicinal material and the above-mentioned clear paste are granulated in a boiling drying granulator in one step, dried, added 0.8% magnesium stearate, mixed evenly, and packed into capsules.

Example 6

Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plumbago, 18 parts of galangal, 25 parts of angelica, 15 parts of Kochia scoparia, according to Example 1 The method is made into capsules.

Example 7

Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plumbago, and 10 parts of oyster, and make capsules according to the method in Example 2.

Example 8

Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine system), 12 parts of plum flower dan, 35 parts of Smilax smilax, 15 parts of white fresh skin, 22 parts of dandelion, 15 parts of purslane Parts are made into capsules according to the method of Example 3.

Example 9

Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine system), 12 parts of plum blossom, 6 parts of Jiangxiang, 12 parts of Panax notoginseng, 20 parts of peach kernel (stir-fried), safflower 8 parts, make capsule according to the method for embodiment 4.

Example 10

Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine system), 12 parts of plumflower dan, 28 parts of rehmannia glutinosa, 8 parts of Baiwei, 20 parts of Moutan bark, according to the method of Example 5 Method made into capsules.

Example 11

Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plum blossom, 25 parts of dodder, 12 parts of privet fruit, 20 parts of Polygonum multiflorum, according to the method of Example 1 Method made into capsules.

Example 12

Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plum flower, 18 parts of box fruit, 15 parts of ebony, 18 parts of tribulus (fried), according to the implementation The method of example 1 is made capsule.

Example 13

Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plumbago, 10 parts of ginseng, 10 parts of wind, 12 parts of Chuanxiong, 20 parts of fennel, rehmannia glutinosa 28 parts, 8 parts of Bai Wei, 20 parts of Cortex Moutan, are made into capsules according to the method of Example 3.

Example 14

Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine system), 12 parts of plum flower dan, 35 parts of Smilax smilax, 15 parts of white fresh skin, 22 parts of dandelion, 15 parts of purslane 25 parts, 25 parts of Dodder, 12 parts of Ligustrum lucidum, 20 parts of Radix Polygoni Multiflori, 10 parts of oysters, capsules are made according to the method of Example 2.

Example 15

Take 60 parts of vernonia, 30 parts of psoraleae, 30 parts of angelica, 10 parts of schisandra (wine), 20 parts of plumflower dan, 8 parts of ginseng, 18 parts of wind, 9 parts of chuanxiong, 32 parts of fennel, according to The method of embodiment 1 is made capsule.

Example 16

Take 30 parts of vernonia, 60 parts of psoralen, 15 parts of angelica, 20 parts of schisandra (wine), 10 parts of plumflower dan, 20 parts of fist ginseng, 9 parts of windproof, 18 parts of chuanxiong, 16 parts of fennel, according to The method of embodiment 1 is made capsule.

Example 17

Take 60 parts of vernonia, 30 parts of psoraleae, 30 parts of angelica, 10 parts of schisandra (made from wine), 20 parts of plumbago, 40 parts of astragalus, and 9 parts of chuanxiong, and make capsules according to the method in Example 2.

Example 18

Take 30 parts of vernonia, 60 parts of psoralen, 15 parts of angelica, 20 parts of schisandra (wine), 10 parts of plum flower, 5 parts of galangal, 30 parts of angelica, 10 parts of Kochia scoparia, according to Example 4 The method is made into capsules.

Example 19

Take 60 parts of vernonia, 30 parts of psoralen, 30 parts of angelica, 10 parts of schisandra (wine), 20 parts of plumbago, 30 parts of galangal, 20 parts of angelica dahurica, 20 parts of Kochia scoparia, and make according to the following method into capsules.

Example 20

Take 60 parts of vernonia, 30 parts of psoralen, 30 parts of angelica, 10 parts of schisandra (wine), 20 parts of plum blossom, 5 parts of oyster, 10 parts of Jiangxiang, 25 parts of Panax notoginseng, 15 parts of peach kernel (stir-fried) 5 parts, 5 parts of safflower, capsules are made according to the method for embodiment 5.

Example 21

Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plum flower, 12 parts of box fruit, 20 parts of ebony, 15 parts of tribulus (fried), according to the implementation The method of example 4 is made capsule.

Example 22

Take 36 parts of vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of schisandra (wine), 12 parts of plum flower, 30 parts of dodder, 10 parts of privet fruit, 25 parts of Polygonum multiflorum, according to the method of embodiment 4 Method made into capsules.

Example 23

Take 30 parts of vernonia, 60 parts of psoralen, 15 parts of angelica, 20 parts of schisandra (wine), 10 parts of plum blossom, 25 parts of rehmannia glutinosa, 10 parts of Baiwei, 15 parts of peony bark, and 20 parts of box fruit vine , 10 parts of ebony plums, 10 parts of Tribulus terrestris (fried), make capsules according to the method of embodiment 3.

Example 24

Take 30 parts of vernonia, 60 parts of psoralen, 15 parts of angelica, 20 parts of schisandra (wine), 10 parts of plum flower, 5 parts of galangal, 30 parts of angelica, 10 parts of Kochia chinensis, 30 parts of oyster, 5 parts of Jiangxiang, 10 parts of Panax notoginseng, 20 parts of peach kernel (stir-fried), and 10 parts of safflower are made into capsules according to the method of Example 1.

In addition to the compositions in the above examples, those skilled in the art can also obtain formulas composed of other raw materials according to the above description, and the above examples do not limit the content of the present invention. In addition, in addition to making the composition into capsules according to conventional methods, the composition of the present invention can also be prepared into tablets, pills, and granules according to conventional methods disclosed in the prior art.

The composition of the invention has no toxic and side effects, can radically cure vitiligo and psoriasis, and has short treatment period and rapid onset of effect. The following clinical experiments are carried out on the medicine of the invention to prove its effect.

1. Clinical trials for the treatment of vitiligo

1. Case source

600 cases of vitiligo patients were selected from major dermatology departments in this city, including 330 males and 270 females; aged 15 to 53 years, with an average of 26.8 years; the course of the disease was 2 months to 18 years, with an average course of 2.0 years; 190 cases in the advanced stage , 410 cases in the stable period. The diagnosis was in line with the diagnostic criteria established by the National Society of Dermatology and Venereology of Integrated Traditional Chinese and Western Medicine.

2. Test method

Patient is divided into 10 groups on average, each group has no statistical difference, each group of patients uses the medicine of the embodiment of the present invention respectively, every day 3 times, each 2 capsules, four weeks is a course of treatment, takes 3 months continuously.

3. Curative effect standard

Significantly effective: the leukoplakia part fades or shrinks, and the area of returning to normal skin color accounts for ≥50% of the skin lesion area;

Effective: the leukoplakia part disappears or shrinks, and the area of returning to normal skin color accounts for ≥10% and <50% of the lesion area;

Ineffective: the area where the white spots return to normal skin color accounts for <10% of the skin lesion area.

4. Treatment results The treatment conditions of patients in each group are shown in Table 1 below.

2. Clinical trials for the treatment of psoriasis

1. Case source

A total of 522 outpatients with psoriasis were selected, including 302 males and 220 females; aged 20 to 65 years, with an average of (40.5±10.8) years; the course of disease was 3 months to 18 years, with an average of (12.4±6.9) years; all patients had Meet the diagnostic criteria for psoriasis vulgaris, and the psoriasis area severity score (PASI) is greater than 10 points.

2. Test method

The patient is divided into 9 groups on average, and there is no statistical difference in gender, age, course of disease, and PASI score difference between groups (P>0.05), which is comparable, and each group of patients uses the medicine of the embodiment of the present invention respectively, every day 3 Time, 2 capsules each time, four weeks as a course of treatment, taking continuously for 3 months.

3. Curative effect standard

The skin lesion area of psoriasis and the psoriasis severity score (PASI) were used as the standard to evaluate the clinical symptoms and signs (squamous, infiltrated, erythema) of the patients. The percentage value of the previous rating. The PASI score reduction index was used as the basis for judging the curative effect.

Significantly effective : PASI score reduction index is above 60%;

Effective : PASI score decline index is 30% to 59%;

Invalid : PASI score decline index is less than 30%.

4. Treatment results

The treatment status of the patients in each group is shown in Table 2 below.

Most of the above-mentioned patients with vitiligo and psoriasis show good results during treatment, and the onset of effect is fast. After further taking this medicine, the patient is basically cured, and during the period of taking the medicine, no adverse reactions occur, which illustrates the present invention. Drugs have basically no toxic side effects on the human body. Above-mentioned patients continue to take medicine of the present invention, and most patients recover from illness after 7-12 courses of treatment, and follow-up survey shows, the recurrence rate of recovery from illness patients within 2 years is lower than 3%.

Claims (7)

1. A traditional Chinese medicine composition for treating skin diseases, characterized in that it comprises the following raw materials in parts by weight: 30-60 parts of vernonia anthelmintic, 30-60 parts of psoralen, 15-30 parts of angelica, 10-60 parts of wine-made schisandra 20 parts, plum blossom 10-20 parts. 2. The traditional Chinese medicine composition according to claim 1, characterized in that it comprises the following raw materials in parts by weight: 36 parts of insect repellent Vernonia, 36 parts of psoralen, 18 parts of angelica, 18 parts of wine-made Schisandra, and 12 parts of plumbago . 3. The traditional Chinese medicine composition according to claim 1 or 2, characterized in that it also includes a synergistic raw material, and the synergistic raw material is one or more groups in the following nine groups: The first group: 10-40 parts of Astragalus, 9-18 parts of Chuanxiong; The second group: 8-20 servings of boxing ginseng, 9-18 servings of Fangfeng, 9-18 servings of Chuanxiong, 16-32 servings of fennel; The third group: 5-30 parts of galangal, 20-30 parts of Angelica dahurica, 10-20 parts of Kochia scoparia; The fourth group: 5 to 30 servings of oysters; The fifth group: 30-40 parts of smilax, 10-25 parts of white fresh skin, 20-25 parts of dandelion, 10-20 parts of purslane; The sixth group: 5-10 servings of Jiangxiang, 10-25 servings of Panax notoginseng, 15-20 servings of fried peach kernel, 5-10 servings of safflower; The seventh group: 25-30 parts of Dihuang, 5-10 parts of Baiwei, 15-30 parts of Moutan bark; The eighth group: 20-30 servings of dodder, 10-15 servings of Ligustrum lucidum, 15-25 servings of Polygonum multiflorum; The ninth group: 12-20 servings of Heguovine, 10-20 servings of ebony plum, 15-20 servings of fried Tribulus terrestris. 4. The traditional Chinese medicine composition according to claim 3, characterized in that it also includes a synergistic raw material, and the synergistic raw material is one or more groups in the following nine groups: The first group: 25 parts of Astragalus, 12 parts of Chuanxiong; The second group: 10 parts of boxing ginseng, 10 parts of Fangfeng, 12 parts of Chuanxiong, 20 parts of fennel; The third group: 18 parts of galangal, 25 parts of Angelica dahurica, 15 parts of Kochia scoparia; The fourth group: 10 servings of oysters; The fifth group: 35 parts of smilax, 15 parts of white fresh skin, 22 parts of dandelion, 15 parts of purslane; The sixth group: 6 parts of Jiangxiang, 12 parts of Panax notoginseng, 20 parts of fried peach kernel, 8 parts of safflower; The seventh group: 28 parts of Dihuang, 8 parts of Baiwei, 20 parts of Moutan bark; The eighth group: 25 parts of dodder, 12 parts of Ligustrum lucidum, 20 parts of Polygonum multiflorum; The ninth group: 18 servings of Heguoteng, 15 servings of ebony plum, and 18 servings of fried Tribulus terrestris. 5. The Chinese medicine composition according to claim 1 or 2, characterized in that: the dosage form is tablet, capsule, pill, granule. 6. a preparation method of the Chinese medicine composition for the treatment of skin diseases as claimed in claim 1, is characterized in that comprising the following steps: (1) Crush the insect repellent Vernonia into fine powder and set aside; (2) Mix the remaining raw materials, extract 2 to 3 times with 65 to 80 vol% ethanol of 6 to 12 mass times, and combine the extracts; (3) Concentrate the extract into a clear or thick paste with a relative density of 1.20-1.40 at 60-80°C; (4) Mix the clear ointment, the fine powder of Vernonia vernium and the medicinal amount of excipients to prepare a traditional Chinese medicine composition in the required dosage form. 7. The application of the traditional Chinese medicine composition for treating skin diseases according to claim 1 in the preparation of medicines for treating vitiligo and psoriasis.