CN102908391A - Chinese medicinal composition for treating dermatosis and preparation method and application thereof - Google Patents

Chinese medicinal composition for treating dermatosis and preparation method and application thereof Download PDF

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CN102908391A
CN102908391A CN2012104379003A CN201210437900A CN102908391A CN 102908391 A CN102908391 A CN 102908391A CN 2012104379003 A CN2012104379003 A CN 2012104379003A CN 201210437900 A CN201210437900 A CN 201210437900A CN 102908391 A CN102908391 A CN 102908391A
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parts
radix
fructus
rhizoma
chinese medicine
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CN102908391B (en
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许东升
韩丽丽
马全龙
谢晓燕
刘永霞
王庆生
王浩骅
孙山
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SHANDONG XINBAO PHARMACEUTICAL CO Ltd
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SHANDONG XINBAO PHARMACEUTICAL CO Ltd
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Abstract

The invention discloses a Chinese medicinal composition for treating dermatosis. The Chinese medicinal composition comprises the following raw materials in parts by weight: 30-60 parts of vernonia anthelmintica, 30-60 parts of malaytea scurfpea fruit, 15-30 parts of Chinese angelica, 10-20 parts of Chinese magnoliavine fruit (alcohol-treated) and 10-20 parts of plumbago zeylanica. The invention further provides a preparation method and an application of the Chinese medicinal composition. The medicament is easy to prepare, is prepared from vernonia anthelmintica and malaytea scurfpea fruit serving as major raw materials and other medicinal components, and has the effects of activating blood, cooling blood, expelling wind, clearing away cold, dissipating blood stasis, killing parasites and curing ringworms; and pathogenesis of vitligo and psoriasis are eliminated fundamentally, focuses of infection are eliminated directly, and the aim of curing is fulfilled.

Description

A kind of dermopathic Chinese medicine composition and its preparation method and application for the treatment of
Technical field
The present invention relates to a kind of dermopathic medicine for the treatment of, be specifically related to a kind of vitiligo and psoriatic Chinese medicine composition for the treatment of, belong to medical technical field.
Background technology
Vitiligo (vitiligo) is that a kind of posteriority melanin takes off the mistake dermatoses, show as clinically differ in size, depigmentation speckle that form differs, number is indefinite, clear-cut margin, the peripheral normal skin of the white macula that has place pigment increases.Leukodermic white macula can betide any position of whole body, but common with fold place skins such as the exposure portion such as face, cervical region, the back of the hand and external genitalia, because white macula is exposed to the appearance that visual position can affect the patient, and then also can have influence on orthobiosis of patient, cause very large mental pressure, therefore the person of seeking medical advice is a lot, and all very urgent.
Psoriasis is commonly called as psoriasis, and sickness rate is high, and the course of disease is longer, and pathogenesis relates to the factors such as heredoimmunity, inflammatory mediator, neurotransmitter, Cell apoptosis and proliferation, microcirculation disturbance.The psoriatic spreads all over all over the world, all can fall ill at different nationalities, sex, age.According to domestic literature, China's psoriatic's sickness rate accounts for 0.5%~2% of total population, nearly 10%~30% psoriatic has family history, the reasons such as chronic, touching repeatedly owing to it, the obstinate difficulty of this disease heals, relapse rate height have a strong impact on patient's social life, cause great health and psychological misery.Simultaneously, because this disease is shown effect repeatedly, often need repeatedly treatment, also bring heavy financial burden to the patient.
A lot for the treatment of vitiligo and psoriatic medicine are arranged now, and existing Chinese medicine also has Western medicine, although can both play a role, can not effect a radical cure, and easily recurrence, drug dependence is strong.How treating a great problem that vitiligo and psoriasis have been the world medicine field, is one of disease of domestic and international skin field primary study control.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention provides a kind of dermopathic Chinese medicine composition for the treatment of, this Chinese medicine composition has the advantage that stability is high, therapeutic effect is good to vitiligo and psoriasis.
The invention also discloses the preparation method and application of said composition, its preparation is simple, evident in efficacy, is convenient to the large application of industrialization.
The present invention is achieved by the following technical solutions:
A kind ofly treat dermopathic Chinese medicine composition, comprise the raw material of following weight portion: 30~60 parts of Caulis Vernoniae andersoniis, 30~60 parts of Fructus Psoraleaes, 15~30 parts of Radix Angelicae Sinensis, 10~20 parts of Fructus Schisandrae Chinensis (processed with wine), 10~20 parts of Radix Plumbaginis Zeylanicaes.
In the above-mentioned Chinese medicine composition, preferably include the raw material of following weight portion: 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes.
Main formula material of the present invention is Caulis Vernoniae andersonii, Fructus Psoraleae, Radix Angelicae Sinensis, Fructus Schisandrae Chinensis, Radix Plumbaginis Zeylanicae, and each crude drug effect is as follows:
Caulis Vernoniae andersonii, the mature fruit of feverfew Caulis Vernoniae andersonii Vernonia anthelmintica Willd.Autumn, picking fruit dried.Mainly originate in Keshen, Aksu Prefecture, Uygur's name Aunar lira in Xinjiang, have heat clearing and inflammation relieving, blood circulation promoting and blood stasis dispelling, the function of parasite killing is used for the treatment of dermatosis.
Fructus Psoraleae, the dry mature fruit of legumes psoraleae Psoralea corylifolia L. has warming the kidney to activate YANG, helping inspiration to relieve asthma, the function of wet spleen antidiarrheal, be used for insufficiency of kidney-YANG, impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffer from a deficiency of the kidney and do to breathe heavily Diarrhoea, external curing vitiligo, alopecia areata.
Radix Angelicae Sinensis, the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels, having enriches blood invigorates blood circulation, the function of menstruction regulating and pain relieving, loosening bowel to relieve constipation, is used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.
Fructus Schisandrae Chinensis, the dry mature fruit of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill. practise to claim " Radix Schisandrae Bicoloris ", has that convergence is astringent or styptic treatment for spontaneous sweating, a function of supplementing QI for promoting the production of body fluid, kidney calming, be used for the chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous sweating, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, palpitation and insomnia.
Radix Plumbaginis Zeylanicae, Plumbaginaceae plant Radix Plumbaginis Zeylanicae Plumbago zeylanis L. is not with the dry stem branch of leaf, and can adopt the whole year, has the function of the dissipating blood stasis that dispels the wind, detoxifcation parasite killing, is used for controlling toxic swelling malignant boil, scabies.
The present invention is aided with the other drug composition take Caulis Vernoniae andersonii, Fructus Psoraleae as main, and promoting blood circulation and cooling blood, expelling wind and cold, dissipating blood stasis blood stasis dispelling, parasite killing are treated tinea, have fundamentally solved vitiligo and psoriatic pathogenic factor, directly except focus, reaches the purpose of radical cure.
On the basis of original prescription, can also add some other potentiation raw material and strengthen curative effect, for example can further add the Radix Astragali, Rhizoma Chuanxiong, play the dissipating blood stasis poison holding, the effect of invigorating QI to consolidate the body surface resistance, formed new side is (weight portion): 30~60 parts of Caulis Vernoniae andersoniis, 30~60 parts of Fructus Psoraleaes, 15~30 parts of Radix Angelicae Sinensis, 10~20 parts of Fructus Schisandrae Chinensis (processed with wine), 10~20 parts of Radix Plumbaginis Zeylanicaes, 10~40 parts of the Radixs Astragali, 9~18 parts of Rhizoma Chuanxiongs, preferred weight part is: 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 25 parts of the Radixs Astragali, 12 parts of Rhizoma Chuanxiongs.
On the basis of original prescription, can also add Rhizoma Bistortae, Radix Saposhnikoviae, Rhizoma Chuanxiong Rhizoma Dioscoreae Hypoglaucae forms new son side, the Rhizoma Bistortae heat-clearing and toxic substances removing, the detumescence hemostasis, the Radix Saposhnikoviae inducing diaphoresis to dispel wind, the pain relieving relieving convulsion, the Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping Rhizoma Dioscoreae Hypoglaucae dampness removing goes turbid, wind expelling stagnation removing, new son side is (weight portion): 30~60 parts of Caulis Vernoniae andersoniis, 30~60 parts of Fructus Psoraleaes, 15~30 parts of Radix Angelicae Sinensis, 10~20 parts of Fructus Schisandrae Chinensis (processed with wine), 10~20 parts of Radix Plumbaginis Zeylanicaes, 8~20 parts of Rhizoma Bistortaes, 9~18 parts of Radix Saposhnikoviaes, 16~32 parts of 9~18 parts of Rhizoma Dioscoreae Hypoglaucaes of Rhizoma Chuanxiong, preferred weight part is: 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 10 parts of Rhizoma Bistortaes, 10 parts of Radix Saposhnikoviaes, 20 parts of 12 parts of Rhizoma Dioscoreae Hypoglaucaes of Rhizoma Chuanxiong.
On the basis of original prescription, can also add Rhizoma Alpiniae Officinarum, the Radix Angelicae Dahuricae, the Fructus Kochiae forms new son side, Rhizoma Alpiniae Officinarum stomach warming preventing or arresting vomiting, dispersing cold for relieving pain, the Radix Angelicae Dahuricae cold expelling that induces sweat, wind-expelling pain-stopping, detumescence and apocenosis, Fructus Kochiae clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching, new son side is (weight portion): 30~60 parts of Caulis Vernoniae andersoniis, 30~60 parts of Fructus Psoraleaes, 15~30 parts of Radix Angelicae Sinensis, 10~20 parts of Fructus Schisandrae Chinensis (processed with wine), 10~20 parts of Radix Plumbaginis Zeylanicaes, 5~30 parts of Rhizoma Alpiniae Officinarums, 20~30 parts of the Radixs Angelicae Dahuricae, 10~20 parts of the Fructus Kochiae, preferred weight part is: 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 18 parts of Rhizoma Alpiniae Officinarums, 25 parts of the Radixs Angelicae Dahuricae, 15 parts of the Fructus Kochiae.
On the basis of original prescription, can also add Concha Ostreae, Concha Ostreae has the effect of YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving, all right trace element supplement, new son side is (weight portion): 30~60 parts of Caulis Vernoniae andersoniis, 30~60 parts of Fructus Psoraleaes, 15~30 parts of Radix Angelicae Sinensis, 10~20 parts of Fructus Schisandrae Chinensis (processed with wine), 10~20 parts of Radix Plumbaginis Zeylanicaes, 5~30 parts of Concha Ostreaes, preferred weight part is: 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 10 parts of Concha Ostreaes.
On the basis of original prescription, can also add Rhizoma Smilacis Glabrae, Cortex Dictamni, Herba Taraxaci, Herba Portulacae, Rhizoma Smilacis Glabrae is the dry rhizome of liliaceous plant smilacis glabra Smilax glabra Roxb., the another name Limonitum, the thorn Polyporus, Cortex Ampelopsis Aconitifoliae Radicis, effect with detoxifcation dehumidifying, Cortex Dictamni has heat clearing and damp drying, the effect of dispeling the wind and detoxifying, Herba Taraxaci has heat-clearing and toxic substances removing, the effect of dispersing swelling and dissipating binds, Herba Portulacae has heat-clearing and toxic substances removing, the effect of cooling blood for hemostasis, new son side is (weight portion): 30~60 parts of Caulis Vernoniae andersoniis, 30~60 parts of Fructus Psoraleaes, 15~30 parts of Radix Angelicae Sinensis, 10~20 parts of Fructus Schisandrae Chinensis (processed with wine), 10~20 parts of Radix Plumbaginis Zeylanicaes, 30~40 parts of Rhizoma Smilacis Glabraes, 10~25 parts of Cortex Dictamni, 20~25 parts of Herba Taraxacis, 10~20 parts of Herba Portulacaes, preferred weight part is: 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 35 parts of Rhizoma Smilacis Glabraes, 15 parts of Cortex Dictamni, 22 parts of Herba Taraxacis, 15 parts of Herba Portulacaes.
On the basis of original prescription, can also add Lignum Dalbergiae Odoriferae, Radix Notoginseng, Semen Persicae, Flos Carthami, the Lignum Dalbergiae Odoriferae promoting flow of QI and blood, regulating QI to relieve pain, the hemostasis of Radix Notoginseng dissipating blood stasis, subduing swelling and relieving pain, the Semen Persicae blood circulation promoting and blood stasis dispelling, the Flos Carthami promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, new son side is (weight portion): 30~60 parts of Caulis Vernoniae andersoniis, 30~60 parts of Fructus Psoraleaes, 15~30 parts of Radix Angelicae Sinensis, 10~20 parts of Fructus Schisandrae Chinensis (processed with wine), 10~20 parts of Radix Plumbaginis Zeylanicaes, 5~10 parts of Lignum Dalbergiae Odoriferaes, 10~25 parts of Radix Notoginseng, 15~20 parts in Semen Persicae (stir-fry), 5~10 parts on Flos Carthami, preferred weight part is: 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 6 parts of Lignum Dalbergiae Odoriferaes, 12 parts of Radix Notoginseng, 20 parts in Semen Persicae (stir-fry), 8 parts on Flos Carthami.
On the basis of original prescription, can also add Radix Rehmanniae, Radix Cynanchi Atrati, Cortex Moutan, the Radix Rehmanniae clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, the Radix Cynanchi Atrati clearing away heat and cooling blood, skin ulcer is treated in detoxifcation, the Cortex Moutan clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, new son side is (weight portion): 30~60 parts of Caulis Vernoniae andersoniis, 30~60 parts of Fructus Psoraleaes, 15~30 parts of Radix Angelicae Sinensis, 10~20 parts of Fructus Schisandrae Chinensis (processed with wine), 10~20 parts of Radix Plumbaginis Zeylanicaes, 25~30 parts of Radix Rehmanniae, 5~10 parts of Radix Cynanchi Atratis, 15~30 parts of Cortex Moutans, preferred weight part is: 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 28 parts of Radix Rehmanniae, 8 parts of Radix Cynanchi Atratis, 20 parts of Cortex Moutans.
On the basis of original prescription, can also add Semen Cuscutae, Fructus Ligustri Lucidi, Radix Polygoni Multiflori, Semen Cuscutae, the Fructus Ligustri Lucidi liver and kidney tonifying, the Radix Polygoni Multiflori removing toxicity for eliminating carbuncles, new son side is (weight portion): 30~60 parts of Caulis Vernoniae andersoniis, 30~60 parts of Fructus Psoraleaes, 15~30 parts of Radix Angelicae Sinensis, 10~20 parts of Fructus Schisandrae Chinensis (processed with wine), 10~20 parts of Radix Plumbaginis Zeylanicaes, 20~30 parts of Semen Cuscutae, 10~15 parts of Fructus Ligustri Lucidi, 15~25 parts of Radix Polygoni Multiflori, preferred weight part is: 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 25 parts of Semen Cuscutae, 12 parts of Fructus Ligustri Lucidi, 20 parts of Radix Polygoni Multiflori.
On the basis of original prescription, can also add box fruit rattan, Fructus Mume, Fructus Tribuli, box fruit rattan (convolvulaceous plant box fruit rattan Operculina turpethum (L.) S.Manso dry rhizome) inducing diuresis to remove edema, relaxing muscles and tendons and activating QI and blood in the collateral, Fructus Mume is astringed the lung, astringing intestine to stop diarrhea, promote the production of body fluid, Fructus Tribuli suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, it is antipruritic to make eye bright, new son side is (weight portion): 30~60 parts of Caulis Vernoniae andersoniis, 30~60 parts of Fructus Psoraleaes, 15~30 parts of Radix Angelicae Sinensis, 10~20 parts of Fructus Schisandrae Chinensis (processed with wine), 10~20 parts of Radix Plumbaginis Zeylanicaes, 12~20 parts in box fruit rattan, 10~20 parts of Fructus Mumes, 15~20 parts of Fructus Tribulis (stir-fry), preferred weight part is: 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 18 parts in box fruit rattan, 15 parts of Fructus Mumes, 18 parts of Fructus Tribulis (stir-fry).
As from the foregoing,Add different synergistic components on the basis of original prescription and can be derived a plurality of son sides, each sub-Fang Junneng plays treatment vitiligo and psoriatic effect, and therapeutic effect is increasing in varying degrees.The synergistic component of respectively organizing that adds in above-mentioned each son side can also use in mutual mixing stack, form new son side, for example, on the basis of original prescription, can add simultaneously Lignum Dalbergiae Odoriferae, Radix Notoginseng, Semen Persicae (stir-fry), Flos Carthami, Radix Rehmanniae, Radix Cynanchi Atrati, Cortex Moutan composition, form new son side, other synergistic components also can be used with.
Chinese medicine composition of the present invention can be made into capsule, also can add corresponding adjuvant and make tablet, pill, granule etc.Preparation different dosage form only used adjuvant is different, effective ingredient or the same, and therapeutic effect is also identical or approximate.The adjuvant of tablet is starch, microcrystalline Cellulose, pregelatinized Starch, lactose, carboxymethylstach sodium, Extra Sodium Carboxylmethyl Starch, low-substituted hydroxypropyl cellulose, hypromellose, Pulvis Talci, magnesium stearate; The adjuvant of pill is starch, microcrystalline Cellulose, carboxymethylstach sodium, hypromellose; The adjuvant of granule is multitudinous Icing Sugar, dextrin; The adjuvant of capsule is starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethylstach sodium, Extra Sodium Carboxylmethyl Starch, hypromellose, Pulvis Talci, silicon dioxide, magnesium stearate.
The preparation method of Chinese medicine composition is characterized in that may further comprise the steps:
(1) Caulis Vernoniae andersonii is ground into fine powder, for subsequent use;
(2) remaining crude drug is mixed, with the ethanol extraction of 65~80vol% of 6~12 quality times 2~3 times, merge extractive liquid;
(3) extracting solution being condensed into 60-80 ℃ of relative density is 1.20~1.40 clear paste or thick paste;
(4) clear paste, Caulis Vernoniae andersonii fine powder are mixed with the adjuvant of survival dose, make the Chinese medicine composition of required dosage form.
In the above-mentioned steps (2), during 2 extractions, each 2h; When extracting for 3 times, 2 hours for the first time, 1 hour for the second time, 1 hour for the second time.
The present invention prepares simply, take Caulis Vernoniae andersonii, Fructus Psoraleae as main, is aided with the other drug composition, effect with promoting blood circulation and cooling blood, expelling wind and cold, dissipating blood stasis blood stasis dispelling, parasite killing treatment tinea, fundamentally solve vitiligo and onset of psoriasis reason, directly except focus, reached the purpose of radical cure.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment, should be understood that, following explanation only is in order to explain the present invention, its content not to be limited.If following crude drug consumption is weight portion without specified otherwise.
Embodiment 1
Get 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, make capsule according to following method:
(1) Caulis Vernoniae andersonii is ground into fine powder, for subsequent use;
(2) all the other medical materials are with the ethanol extraction 3 times of 8 times of amount 75vol%, and 2 hours for the first time, 1 hour for the second time, 1 hour for the second time, merge extractive liquid, filtered, and filtrate is concentrated into the thick paste that relative density is 1.20~1.30 (70 ℃);
(3) with Caulis Vernoniae andersonii fine powder and above-mentioned thick paste mixing, drying gets dry extract;
(4) dried cream powder is broken into fine powder, adds an amount of pharmaceutic adjuvant, mixing is granulated, drying, and the magnesium stearate of adding 1%, mixing, encapsulated, and get final product every dress 0.5g.
Embodiment 2
Get 30 parts of Caulis Vernoniae andersoniis, 60 parts of Fructus Psoraleaes, 15 parts of Radix Angelicae Sinensis, 20 parts of Fructus Schisandrae Chinensis (processed with wine), 10 parts of Radix Plumbaginis Zeylanicaes, make capsule according to following method:
(1) Caulis Vernoniae andersonii is ground into fine powder, for subsequent use;
(2) all the other medical materials are measured the 80vol% ethanol extractions 2 times with 6 times, and each 2 hours, merge extractive liquid, filtered, and filtrate is concentrated into the thick paste that relative density is 1.25~1.35 (60 ℃);
(3) with medical material fine powder and above-mentioned thick paste mixing, drying gets dry extract;
(4) dried cream powder is broken into fine powder, adds an amount of pharmaceutic adjuvant, mixing is granulated, drying, and the magnesium stearate of adding 0.5%, mixing, encapsulated, and get final product every dress 0.5g.
Embodiment 3
Get 60 parts of Caulis Vernoniae andersoniis, 30 parts of Fructus Psoraleaes, 30 parts of Radix Angelicae Sinensis, 10 parts of Fructus Schisandrae Chinensis (processed with wine), 20 parts of Radix Plumbaginis Zeylanicaes, make capsule according to following method:
(1) Caulis Vernoniae andersonii is ground into fine powder, for subsequent use;
(2) all the other medical materials are measured the 65vol% ethanol extractions 2 times with 12 times, and each 2 hours, merge extractive liquid, filtered, and filtrate is concentrated into the thick paste that relative density is 1.30~1.35 (80 ℃);
(3) with medical material fine powder and above-mentioned thick paste mixing, drying gets dry extract;
(4) dried cream powder is broken into fine powder, adds an amount of pharmaceutic adjuvant, mixing is granulated, drying, and the magnesium stearate of adding 0.8%, mixing, encapsulated, and get final product every dress 0.5g.
Embodiment 4
Get 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 25 parts of the Radixs Astragali, 12 parts of Rhizoma Chuanxiongs, make capsule according to following method:
(1) Caulis Vernoniae andersonii is ground into fine powder, for subsequent use;
(2) all the other medical materials are measured the 70vol% ethanol extractions 2 times with 10 times, and each 2 hours, merge extractive liquid, filtered, and filtrate is concentrated into the thick paste that relative density is 1.25~1.35 (75 ℃);
(3) with medical material fine powder and above-mentioned thick paste mixing, drying gets dry extract;
(4) dried cream powder is broken into fine powder, adds an amount of pharmaceutic adjuvant, mixing is granulated, drying, and the magnesium stearate of adding 1.5%, mixing, encapsulated, and get final product every dress 0.5g.
Embodiment 5
Get 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 10 parts of Rhizoma Bistortaes, 10 parts of Radix Saposhnikoviaes, 12 parts of Rhizoma Chuanxiongs, 20 parts of Rhizoma Dioscoreae Hypoglaucaes, make capsule according to following method:
(1) Caulis Vernoniae andersonii is ground into fine powder, for subsequent use;
(2) all the other medical materials are measured the 80vol% ethanol extractions 2 times with 8 times, and each 2 hours, merge extractive liquid, filtered, and filtrate is concentrated into the clear paste that relative density is 1.20~1.25 (80 ℃);
(3) one-step palletizing in fluidized drying pelletizer with medical material fine powder and above-mentioned clear paste, drying, the magnesium stearate of adding 0.8%, mixing, encapsulated, and get final product every dress 0.5g.
Embodiment 6
Get 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 18 parts of Rhizoma Alpiniae Officinarums, 25 parts of the Radixs Angelicae Dahuricae, 15 parts of the Fructus Kochiae, make capsule according to the method for embodiment 1.
Embodiment 7
Get 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 10 parts of Concha Ostreaes, make capsule according to the method for embodiment 2.
Embodiment 8
Get 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 35 parts of Rhizoma Smilacis Glabraes, 15 parts of Cortex Dictamni, 22 parts of Herba Taraxacis, 15 parts of Herba Portulacaes, make capsule according to the method for embodiment 3.
Embodiment 9
Get 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 6 parts of Lignum Dalbergiae Odoriferaes, 12 parts of Radix Notoginseng, 20 parts in Semen Persicae (stir-fry), 8 parts on Flos Carthami, make capsule according to the method for embodiment 4.
Embodiment 10
Get 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 28 parts of Radix Rehmanniae, 8 parts of Radix Cynanchi Atratis, 20 parts of Cortex Moutans, make capsule according to the method for embodiment 5.
Embodiment 11
Get 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 25 parts of Semen Cuscutae, 12 parts of Fructus Ligustri Lucidi, 20 parts of Radix Polygoni Multiflori, make capsule according to the method for embodiment 1.
Embodiment 12
Get 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 18 parts in rattan of box fruit, 15 parts of Fructus Mumes, 18 parts of Fructus Tribulis (stir-fry), make capsule according to the method for embodiment 1.
Embodiment 13
Get 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 10 parts of Rhizoma Bistortaes, 10 parts of Radix Saposhnikoviaes, 12 parts of Rhizoma Chuanxiongs, 20 parts of Rhizoma Dioscoreae Hypoglaucaes, 28 parts of Radix Rehmanniae, 8 parts of Radix Cynanchi Atratis, 20 parts of Cortex Moutans, make capsule according to the method for embodiment 3.
Embodiment 14
Get 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 35 parts of Rhizoma Smilacis Glabraes, 15 parts of Cortex Dictamni, 22 parts of Herba Taraxacis, 15 parts of Herba Portulacaes, 25 parts of Semen Cuscutae, 12 parts of Fructus Ligustri Lucidi, 20 parts of Radix Polygoni Multiflori, 10 parts of Concha Ostreaes, make capsule according to the method for embodiment 2.
Embodiment 15
Get 60 parts of Caulis Vernoniae andersoniis, 30 parts of Fructus Psoraleaes, 30 parts of Radix Angelicae Sinensis, 10 parts of Fructus Schisandrae Chinensis (processed with wine), 20 parts of Radix Plumbaginis Zeylanicaes, 8 parts of Rhizoma Bistortaes, 18 parts of Radix Saposhnikoviaes, 9 parts of Rhizoma Chuanxiongs, 32 parts of Rhizoma Dioscoreae Hypoglaucaes, make capsule according to the method for embodiment 1.
Embodiment 16
Get 30 parts of Caulis Vernoniae andersoniis, 60 parts of Fructus Psoraleaes, 15 parts of Radix Angelicae Sinensis, 20 parts of Fructus Schisandrae Chinensis (processed with wine), 10 parts of Radix Plumbaginis Zeylanicaes, 20 parts of Rhizoma Bistortaes, 9 parts of Radix Saposhnikoviaes, 18 parts of Rhizoma Chuanxiongs, 16 parts of Rhizoma Dioscoreae Hypoglaucaes, make capsule according to the method for embodiment 1.
Embodiment 17
Get 60 parts of Caulis Vernoniae andersoniis, 30 parts of Fructus Psoraleaes, 30 parts of Radix Angelicae Sinensis, 10 parts of Fructus Schisandrae Chinensis (processed with wine), 20 parts of Radix Plumbaginis Zeylanicaes, 40 parts of the Radixs Astragali, 9 parts of Rhizoma Chuanxiongs, make capsule according to the method for embodiment 2.
Embodiment 18
Get 30 parts of Caulis Vernoniae andersoniis, 60 parts of Fructus Psoraleaes, 15 parts of Radix Angelicae Sinensis, 20 parts of Fructus Schisandrae Chinensis (processed with wine), 10 parts of Radix Plumbaginis Zeylanicaes, 5 parts of Rhizoma Alpiniae Officinarums, 30 parts of the Radixs Angelicae Dahuricae, 10 parts of the Fructus Kochiae, make capsule according to the method for embodiment 4.
Embodiment 19
Get 60 parts of Caulis Vernoniae andersoniis, 30 parts of Fructus Psoraleaes, 30 parts of Radix Angelicae Sinensis, 10 parts of Fructus Schisandrae Chinensis (processed with wine), 20 parts of Radix Plumbaginis Zeylanicaes, 30 parts of Rhizoma Alpiniae Officinarums, 20 parts of the Radixs Angelicae Dahuricae, 20 parts of the Fructus Kochiae, make capsule according to following method.
Embodiment 20
Get 60 parts of Caulis Vernoniae andersoniis, 30 parts of Fructus Psoraleaes, 30 parts of Radix Angelicae Sinensis, 10 parts of Fructus Schisandrae Chinensis (processed with wine), 20 parts of Radix Plumbaginis Zeylanicaes, 5 parts of Concha Ostreaes, 10 parts of Lignum Dalbergiae Odoriferaes, 25 parts of Radix Notoginseng, 15 parts in Semen Persicae (stir-fry), 5 parts on Flos Carthami, make capsule according to the method for embodiment 5.
Embodiment 21
Get 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 12 parts in rattan of box fruit, 20 parts of Fructus Mumes, 15 parts of Fructus Tribulis (stir-fry), make capsule according to the method for embodiment 4.
Embodiment 22
Get 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of Fructus Schisandrae Chinensis (processed with wine), 12 parts of Radix Plumbaginis Zeylanicaes, 30 parts of Semen Cuscutae, 10 parts of Fructus Ligustri Lucidi, 25 parts of Radix Polygoni Multiflori, make capsule according to the method for embodiment 4.
Embodiment 23
Get 30 parts of Caulis Vernoniae andersoniis, 60 parts of Fructus Psoraleaes, 15 parts of Radix Angelicae Sinensis, 20 parts of Fructus Schisandrae Chinensis (processed with wine), 10 parts of Radix Plumbaginis Zeylanicaes, 25 parts of Radix Rehmanniae, 10 parts of Radix Cynanchi Atratis, 15 parts of Cortex Moutans, 20 parts in rattan of box fruit, 10 parts of Fructus Mumes, 10 parts of Fructus Tribulis (stir-fry), make capsule according to the method for embodiment 3.
Embodiment 24
Get 30 parts of Caulis Vernoniae andersoniis, 60 parts of Fructus Psoraleaes, 15 parts of Radix Angelicae Sinensis, 20 parts of Fructus Schisandrae Chinensis (processed with wine), 10 parts of Radix Plumbaginis Zeylanicaes, 5 parts of Rhizoma Alpiniae Officinarums, 30 parts of the Radixs Angelicae Dahuricae, 10 parts of the Fructus Kochiae, 30 parts of Concha Ostreaes, 5 parts of Lignum Dalbergiae Odoriferaes, 10 parts of Radix Notoginseng, 20 parts in Semen Persicae (stir-fry), 10 parts on Flos Carthami, make capsule according to the method for embodiment 1.
The compositions in above-described embodiment, those skilled in the art can also obtain the prescription that other raw materials form according to foregoing description, and above-described embodiment is not that content of the present invention is limited.In addition, except according to conventional method compositions being made the capsule, can also the present composition be made tablet, pill, granule according to disclosed conventional method in the prior art.
Compositions of the present invention has no side effect, and can effect a radical cure vitiligo and psoriasis, and treatment cycle is short, and rapid-action, the below carries out clinical experiment to medicine of the present invention, proves its effect.
One, treatment vitiligo clinical experiment
1, case source
Choose 600 routine patients with vitiligo at each large Dermatology of this city, male 330 examples wherein, women 270 examples; 15~53 years old age, average 26.8 years old; The course of disease 2 months~18 years, average course of disease 2.0 years; Progressive stages 190 example, stable phase 410 examples.Its diagnosis all meets the fixed diagnostic criteria of national combination of Chinese and Western medicine Society of Dermatology and Venereology's pigment disease length of schooling.
2, test method
The patient is equally divided into 10 groups, and each organizes no difference of science of statistics, and every group of patient uses respectively the medicine of the embodiment of the invention, and every day 3 times, each 2 is a course for the treatment of all around, takes continuously 3 months.
3, criterion of therapeutical effect
Produce effects: white macula partly disappears or dwindles, and the area that recovers the normal colour of skin accounts for skin lesion area 〉=50%;
Effectively: white macula partly disappears or dwindles, the area that recovers the normal colour of skin account for skin lesion area 〉=10% and<50%;
Invalid: the area that white macula recovers the normal colour of skin accounts for skin lesion area<10%.
4, therapeutic outcome is respectively organized the patient treatment situation and is seen the following form 1.
Two, treatment psoriasis clinical experiment
1, case source
Select outpatient service psoriatic 522 examples, male 302 examples wherein, women 220 examples; 20~65 years old age, average (40.5 ± 10.8) year; Course of disease March~18 years, average (12.4 ± 6.9) year; All patients all meet the psoriasis vulgaris diagnostic criteria, and psoriasis area severity scoring (PASI) all divides greater than 1O.
2, test method
The patient is equally divided into 9 groups, and Gender between group, age, the course of disease, the equal no difference of science of statistics of PASI diversity of values (P〉0.05), have comparability, every group of patient uses respectively the medicine of the embodiment of the invention, every day 3 times, each 2, be a course for the treatment of all around, took continuously 3 months.
3, criterion of therapeutical effect
Mark (PASI) as standard with psoriatic skin injury area and psoriasis severity, clinical symptoms and sign (squama, infiltration, erythema) to the patient are estimated, and PASI decline index is the difference of scoring before and after treating and the percent value of the front scoring for the treatment of.With the foundation of PASI scoring decline index as efficacy determination.
Produce effects: PASI scoring decline index is more than 60%;
Effectively: PASI scoring decline index is 30%~59%;
Invalid: PASI scoring decline index is less than 30%.
4, therapeutic outcome
Each is organized the patient treatment situation and sees the following form 2.
Above-mentioned vitiligo and the psoriatic overwhelming majority when treatment shows good effect, and rapid-action, through further taking this medicine, the patient cures substantially, and during drug administration, the generation that has no adverse reaction illustrates that medicine of the present invention has no side effect to human body basic.Above-mentioned patient continues to take medicine of the present invention, and most of patient fully recovered 7-12 the course for the treatment of, and follow-up investigation shows that the relapse rate of recovery from illness patient in 2 years is lower than 3%.

Claims (7)

1. treat dermopathic Chinese medicine composition for one kind, it is characterized in that comprising the raw material of following weight portion: 30~60 parts of Caulis Vernoniae andersoniis, 30~60 parts of Fructus Psoraleaes, 15~30 parts of Radix Angelicae Sinensis, 10~20 parts of processed with wine Fructus Schisandrae Chinensis, 10~20 parts of Radix Plumbaginis Zeylanicaes.
2. Chinese medicine composition according to claim 1 is characterized in that comprising the raw material of following weight portion: 36 parts of Caulis Vernoniae andersoniis, 36 parts of Fructus Psoraleaes, 18 parts of Radix Angelicae Sinensis, 18 parts of processed with wine Fructus Schisandrae Chinensis, 12 parts of Radix Plumbaginis Zeylanicaes.
3. Chinese medicine composition according to claim 1 and 2 is characterized in that also comprising the potentiation raw material, and described potentiation raw material is one or more groups in following nine groups:
First group: 10~40 parts of the Radixs Astragali, 9~18 parts of Rhizoma Chuanxiongs;
Second group: 8~20 parts of Rhizoma Bistortaes, 9~18 parts of Radix Saposhnikoviaes, 9~18 parts of Rhizoma Chuanxiongs, 16~32 parts of Rhizoma Dioscoreae Hypoglaucaes;
The 3rd group: 5~30 parts of Rhizoma Alpiniae Officinarums, 20~30 parts of the Radixs Angelicae Dahuricae, 10~20 parts of the Fructus Kochiae;
The 4th group: 5~30 parts of Concha Ostreaes;
The 5th group: 30~40 parts of Rhizoma Smilacis Glabraes, 10~25 parts of Cortex Dictamni, 20~25 parts of Herba Taraxacis, 10~20 parts of Herba Portulacaes;
The 6th group: 5~10 parts of Lignum Dalbergiae Odoriferaes, 10~25 parts of Radix Notoginseng, 15~20 parts of Semen Persicae (parched)s, 5~10 parts on Flos Carthami;
The 7th group: 25~30 parts of Radix Rehmanniae, 5~10 parts of Radix Cynanchi Atratis, 15~30 parts of Cortex Moutans;
The 8th group: 20~30 parts of Semen Cuscutae, 10~15 parts of Fructus Ligustri Lucidi, 15~25 parts of Radix Polygoni Multiflori;
The 9th group: 12~20 parts in rattan of box fruit, 10~20 parts of Fructus Mumes, 15~20 parts of stir-baked FRUCTUS TRIBULIs.
4. Chinese medicine composition according to claim 3 is characterized in that also comprising the potentiation raw material, and described potentiation raw material is one or more groups in following nine groups:
First group: 25 parts of the Radixs Astragali, 12 parts of Rhizoma Chuanxiongs;
Second group: 10 parts of Rhizoma Bistortaes, 10 parts of Radix Saposhnikoviaes, 12 parts of Rhizoma Chuanxiongs, 20 parts of Rhizoma Dioscoreae Hypoglaucaes;
The 3rd group: 18 parts of Rhizoma Alpiniae Officinarums, 25 parts of the Radixs Angelicae Dahuricae, 15 parts of the Fructus Kochiae;
The 4th group: 10 parts of Concha Ostreaes;
The 5th group: 35 parts of Rhizoma Smilacis Glabraes, 15 parts of Cortex Dictamni, 22 parts of Herba Taraxacis, 15 parts of Herba Portulacaes;
The 6th group: 6 parts of Lignum Dalbergiae Odoriferaes, 12 parts of Radix Notoginseng, 20 parts of Semen Persicae (parched)s, 8 parts on Flos Carthami;
The 7th group: 28 parts of Radix Rehmanniae, 8 parts of Radix Cynanchi Atratis, 20 parts of Cortex Moutans;
The 8th group: 25 parts of Semen Cuscutae, 12 parts of Fructus Ligustri Lucidi, 20 parts of Radix Polygoni Multiflori;
The 9th group: 18 parts in rattan of box fruit, 15 parts of Fructus Mumes, 18 parts of stir-baked FRUCTUS TRIBULIs.
5. Chinese medicine composition according to claim 1 and 2, it is characterized in that: dosage form is tablet, capsule, pill, granule.
6. the preparation method of the dermopathic Chinese medicine composition for the treatment of claimed in claim 1 is characterized in that may further comprise the steps:
(1) Caulis Vernoniae andersonii is ground into fine powder, for subsequent use;
(2) remaining crude drug is mixed, with the ethanol extraction of 65~80vol% of 6~12 quality times 2~3 times, merge extractive liquid;
(3) extracting solution being condensed into 60-80 ℃ of relative density is 1.20~1.40 clear paste or thick paste;
(4) clear paste, Caulis Vernoniae andersonii fine powder are mixed with the adjuvant of survival dose, make the Chinese medicine composition of required dosage form.
7. the application of the dermopathic Chinese medicine composition for the treatment of claimed in claim 1 in preparation treatment vitiligo and psoriasis.
CN201210437900.3A 2012-11-06 2012-11-06 Chinese medicinal composition for treating dermatosis and preparation method and application thereof Active CN102908391B (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103461611A (en) * 2013-10-09 2013-12-25 北京绿源求证科技发展有限责任公司 Food health tea infusion dissolved medicine for improving vitiligo
CN103830379A (en) * 2014-03-03 2014-06-04 新疆吐鲁番地区维吾尔医医院 Blood purifying mixture for treating skin diseases
CN106063870A (en) * 2016-08-17 2016-11-02 施泽晶 A kind of Chinese medicine composition treating damp abundance due to splenic asthenia type dermatitis and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103461611A (en) * 2013-10-09 2013-12-25 北京绿源求证科技发展有限责任公司 Food health tea infusion dissolved medicine for improving vitiligo
CN103830379A (en) * 2014-03-03 2014-06-04 新疆吐鲁番地区维吾尔医医院 Blood purifying mixture for treating skin diseases
CN106063870A (en) * 2016-08-17 2016-11-02 施泽晶 A kind of Chinese medicine composition treating damp abundance due to splenic asthenia type dermatitis and preparation method thereof

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