CN103920028A - Pharmaceutical composition for treating diabetes and preparation method of preparation thereof - Google Patents
Pharmaceutical composition for treating diabetes and preparation method of preparation thereof Download PDFInfo
- Publication number
- CN103920028A CN103920028A CN201410131616.2A CN201410131616A CN103920028A CN 103920028 A CN103920028 A CN 103920028A CN 201410131616 A CN201410131616 A CN 201410131616A CN 103920028 A CN103920028 A CN 103920028A
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- preparation
- radix
- diabetes
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a pharmaceutical composition for treating diabetes and a preparation method of a preparation thereof and particularly relates to a traditional Chinese medicine preparation which is prepared from the following medicines: ginseng, astragalus membranaceus, angelica sinensis, gypsum, dried radix rehmanniae, rhizoma anemarrhenae, radices trichosanthis, the root of kudzu vine, patrinia, common andrographis herb, coptis chinensis, cortex mori radicis, radix polygonati officinalis, rhizoma atractylodis macrocephalae, dandelion, Chinese yam, ophiopogon roots, schisandra chinensis, medlar, radix scrophulariae, cortex lycii radicis, raw hawthorn, raw liquorice, dried rehmannia root, corn stigma and the like. The pharmaceutical composition provided by the invention diminishes inflammation and relieves toxicity, has a good curative effect on diabetes, and can recover the pancreas function of a patient, nourish the liver, kidneys and spleen and prevent complications.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and formulation preparation method thereof, be specifically related to a kind of preparation method of pharmaceutical composition and preparation thereof for the treatment of diabetes.
Background technology
Diabetes are classified as " one of world-famous puzzle " by World Health Organization (WHO).The cause of disease of diabetes, the traditional Chinese medical science is cured Zhang Zhongjing as far back as the sage in twoth century of Christian era and is just early finalized.This disease belongs to " diabetes " category, and its cause of disease is " the plain body deficiency of YIN "." pathogenic fire " invasion human body of one of six climate exopathogens, from outward appearance to inner essence, injures lung gradually, lung-heat impairment of body fluid, and disease is seen excessive thirst polydipsia, on meaning, disappears.Injure stomach, stomach excessive heat, card is shown in and polyorexia disappears among meaning.Injure kidney, damage of kidney-YIN, disease is seen urinary micturition, under meaning, disappears.Some appellations " three eliminating masses " are also resultant.Due to social development, the raising of people's living standard and the change of life style, China's onset diabetes rate is in rising trend, according to interrelated data introduction, China in recent years diabetic number increases severely, and sickness rate is more than 6/1000ths, clinical manifestation is more with person in middle and old age, " three-many-one-little " and polydipsia polyphagia polyuria, lose weight, and is Clinical symptoms.Doctor trained in Western medicine adopts the Western medicine control blood sugar for human body of oral " metformin ", " Ge Liekate sheet " and so on to raise mostly now, and its side effect is impairing the liver, injures one's stomach, is impairment of the kidney.Or insulin injection, but all unavoidably there will be equally " complication ", only the morning of time is slow.
Summary of the invention
The object of the invention is in order to overcome above deficiency, a kind of blood sugar lowering antiinflammatory simultaneously detoxification is provided, diabetes are had to good therapeutic effect, recover pancreatic functions, invigorating the liver and kidney spleen, prevents the medicine of the generation of complication.
The present invention selects Radix Ginseng, the Radix Astragali, Radix Angelicae Sinensis, Gypsum Fibrosum, the Radix Rehmanniae, the Rhizoma Anemarrhenae, Radix Trichosanthis, Radix Puerariae, Herba Patriniae, Herba Andrographis, Rhizoma Coptidis, Cortex Mori, Rhizoma Polygonati Odorati, the Rhizoma Atractylodis Macrocephalae, Herba Taraxaci Rhizoma Dioscoreae, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Fructus Lycii, Radix Scrophulariae, Cortex Lycii, Fructus Crataegi, Radix Glycyrrhizae, Radix Rehmanniae, Stigma Maydis.
Wherein Radix Ginseng: strongly invigorating primordial QI, multiple arteries and veins is admittedly de-, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the Fructus Alpiniae Oxyphyllae of calming the nerves.The Radix Astragali: the Radix Astragali has effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.Radix Angelicae Sinensis: warm in nature, sweet in the mouth is pungent, GUIXIN, liver, spleen channel, benefiting blood and regulating blood circulation.Gypsum Fibrosum: expelling pathogenic factors from muscles for clearing heat, relieving restlessness is quenched the thirst.The Radix Rehmanniae: clearing away heat and cooling blood effect is for the warm febrile disease blood of joining the army, high fever coma, the effect of xerostomia crimson tongue.The Rhizoma Anemarrhenae: clearing away heat-fire, promotes the production of body fluid and moisturizes.Radix Trichosanthis: clearing away heat-fire, promoting the production of body fluid to quench thirst, evacuation of pus detumescence.Radix Puerariae: have the effects such as blood sugar lowering, blood fat, antiinflammatory, having induces sweat brings down a fever, promoting the production of body fluid to quench thirst, antidiarrheal.Herba Patriniae: heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.Herba Andrographis: heat-clearing and toxic substances removing, removing heat from blood detumescence.Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication also has blood pressure lowering, adjusts blood fat, blood sugar lowering, arrhythmia and protection cardiac muscle wait effect.Cortex Mori: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.Rhizoma Polygonati Odorati: lung is put down, returned to sweet in the mouth, property, stomach warp; There is lung moistening YIN nourishing, the effect of nourishing the stomach to promote the production of body fluid.The Rhizoma Atractylodis Macrocephalae: spleen reinforcing, stomach reinforcing, dampness, and in.Herba Taraxaci: sweet, micro-bitter heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Rhizoma Dioscoreae: sweet in the mouth is flat, both can QI invigorating, again can yin nourishing, and its effect is gentle, cold not dry, QI invigorating and not stagnant, yin nourishing and oiliness, has the flat title of mending three warmers, and tool adstringency slightly, but especially the most outstanding with tonifying the spleen and stomach merit.Radix Ophiopogonis: blood sugar lowering, immunomodulating, resist myocardial ischemia, the aspect such as anoxia enduring, antiallergic and asthma all has pharmacological action.Fructus Schisandrae Chinensis: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Fructus Lycii: have the effect of improving eyesight, blood sugar lowering, flat blood pressure.Radix Scrophulariae: pathogenic warmth is joined the army, the pericardium that caves in, maculae caused by violent heat pathogen, constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus are hindered in consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin.Cortex Lycii: cooling blood for hemostasis, clearing deficient heat, eliminating heat from the lung, heat clearing away YIN nourishing, heat-clearing and toxic substances removing.Fructus Crataegi: promoting flow of QI and blood dissipating blood stasis.Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Radix Rehmanniae: nature and flavor are sweet, hardship, cold, there is clearing away heat and cooling blood, effect of YIN nourishing and the production of body fluid promoting, is heat removing and blood cooling medicine.Stigma Maydis: sweet in the mouth, light, property is flat, returns kidney, liver, gallbladder meridian.
A kind of pharmaceutical composition for the treatment of diabetes of the present invention, this pharmaceutical composition comprises the raw material of Chinese medicine of following weight proportion:
Wherein, as optimal drug compositions, this pharmaceutical composition comprises the raw material of Chinese medicine of following weight proportion:
Or
Or
More than, in composition, magistral medicines, with 80 order-100 order grinds, is added to 1200 grams of water, boil 30-40 minute, after water is opened, slow fire boils, and when remaining 400 grams of water just stops, after filtered through gauze, obtains oral liquid.
More than composition is by weight as proportioning, in the time of actual production, can increase accordingly or reduce according to proportioning, if large-scale production can taking kilogram or ton as unit, but the constant rate of each constituent weight proportion.
The ratio of above weight proportion obtains through science screening, for special patient, and as serious symptom or light disease, fat or modest patient, proportioning that can corresponding adjustment weight, increases or reduces that to be no more than 50% drug effect constant.
Chinese medicine preparation of the present invention is that the raw material of Chinese medicine consisting of above-mentioned formula forms through grinding, boiling, finally with drink form, for patient takes.
The most preferred preparation method of the present invention of above-mentioned oral liquid formulations is as follows:
By the 25-component medicine in filling a prescription above, with 80 order-100 order grinds, add 1200 grams of water, boil 30-40 minute, after water is opened, slow fire boils, and when remaining 400 grams of water just stops, after filtered through gauze, obtains oral liquid.
Its function of Chinese medicine preparation of the present invention with cure mainly into:
1, to diabetics, blood sugar lowering antiinflammatory simultaneously detoxification, and diabetes are had to good therapeutic effect.
2, can recover patient's pancreatic functions, mend liver,kidney,spleen, prevent the generation of complication.
Detailed description of the invention
In order to make those skilled in the art understand better technical scheme of the present invention; technical scheme of the present invention is carried out to clear, complete description; based on the embodiment in the application; other embodiment roughly the same that those of ordinary skill in the art obtain under the prerequisite of not making creative work, should belong to the scope of the application's protection.
Below in conjunction with detailed description of the invention, the present invention is further illustrated, but not as limitation of the present invention.
Embodiment mono-,
By the 25-component medicine in filling a prescription above, with 80 order-100 order grinds, add 1200 grams of water, boil 30-40 minute, after water is opened, slow fire boils, and when remaining 400 grams of water just stops, then, after filtered through gauze, obtains oral liquid.
Embodiment bis-,
By the 25-component medicine in filling a prescription above, with 80 order-100 order grinds, add 1200 grams of water, boil 30-40 minute, after water is opened, slow fire boils, and when remaining 400 grams of water just stops, then, after filtered through gauze, obtains oral liquid.
Embodiment tri-,
By the 25-component medicine in filling a prescription above, with 80 order-100 order grinds, add 1200 grams of water, boil 30-40 minute, after water is opened, slow fire boils, and when remaining 400 grams of water just stops, then, after filtered through gauze, obtains oral liquid.
Diabetics can once be taken 200 grams, sooner or later takes, and one after each meal, a month course for the treatment of, two to three courses for the treatment of, can see good therapeutic effect, and patient need avoid Adeps Sus domestica and sweet food simultaneously, and therapeutic effect can be better.
The toxicity of the present invention of test determination below and drug effect thereof
Acute toxicity test: observe oral liquid of the present invention to mouse stomach administration after acute toxic reaction and the death condition of animal.
(1) trial drug: oral liquid 200g of the present invention, the Cmax that this medicine can be joined to the administration of mice is 42%.
(2) experimental animal: KM mice, SPF level, male and female dual-purpose, body weight 18～22g, animal is pressed sex sub-cage rearing, and 5/cage, food SPF level solid feed, drinking water is freely.
(3) test method and result:
Test prerun: get 18 of mices in 4 week age, male and female half and half, are divided into 3 groups at random, and 6 every group, fasting is after 12 hours, and gavage gives 10.5%, 21%, 42% medicine oral liquid of the present invention respectively, 2 times on the one, interval 6h.Observe 14 days, result is without dead mouse,
Formal test: separately get 40 of mices in 4 week age, male and female half and half, fasting is after 12 hours, and gavage is given 42% medicine, 2 times on the one, interval 6h.
Viewing duration mice finds no other toxic reactions.When experiment finishes, put to death mice, dissect perusal main organs color and morphological change, the main organs no abnormality seens such as the result heart, liver, spleen, lung, kidney, stomach, intestinal change.
3, pharmacodynamic experiment:
Animal
Male mice in kunming, the healthy mice of body weight (20 ± 2) g.
Laboratory animal grouping and modeling:
1. diabetes model is set up
Mouse tail vein injection alloxan 0.09mg/g, 72h posterior orbit is got blood and is surveyed blood glucose, selects the above person of blood glucose 13.875mmol/L (250mg/dL) for experiment.
2. grouping
Get and screen 60 of mices, be divided at random three groups of groups, 20 every group, be respectively normal health mice A, intravenous injection alloxan 0.09mg/g as a control group, 72h posterior orbit is got blood and is surveyed blood glucose, selects 20 of blood glucose 13.875mmol/L (250mg/dL) above persons as experimental group B.Alternative is got intravenous injection alloxan 0.09mg/g, 72h posterior orbit is got blood and is surveyed blood glucose, select 20 of the above persons of blood glucose 13.875mmol/L (250mg/dL) to organize C as blank, get at random 20 of control group A, experimental group B20 only, get a kind of made oral medicine liquid of pharmaceutical composition for the treatment of diabetes of the present invention, give respectively the administration of A, B group mouse stomach
Detect index
Observe mice general status.After administration, in A group Mice Body, blood glucose is normal, in B group C group Mice Body, blood glucose all remains on higher level, after two weeks, observe, in A group Mice Body, blood glucose is still in normal level, blood glucose in B group Mice Body declines to some extent, but or higher than the blood sugar content in A group Mice Body, blood glucose in C group Mice Body is still in higher level, there is no downward trend, after two weeks, observe three groups of mices, wherein the blood glucose of A group mice is still normal level, by chemical examination, the blood sugar content of B group mice has been tending towards normal level, and blood sugar content in C group Mice Body is still in higher level.
Overview
The control group A mice mental status is good, and fur is smooth, and activity is large, and experiment group B group mice has just started lethargy in a week, emaciated physique, hypotrichosis, lazy moving, after three weeks, the mental status is good, and fur is smooth, and activity is large, blank group C group mice lethargy, emaciated physique, hypotrichosis, lazy moving.
Result shows, a kind of pharmaceutical composition for the treatment of diabetes of the present invention, can significantly reduce the blood glucose of mice.Meanwhile, toxicity of the present invention is less, has suitable advantage in the treatment of diabetes.
Above-described embodiment is that foregoing of the present invention is further described, but this should be interpreted as to the scope of the above-mentioned theme of the present invention only limits to above-described embodiment.All technology realizing based on foregoing all belong to scope of the present invention.
Claims (7)
1. treat a pharmaceutical composition for diabetes, this pharmaceutical composition comprises the raw material of Chinese medicine of following weight proportion:
。
2. a kind of pharmaceutical composition for the treatment of diabetes according to claim 1, is characterized in that, this pharmaceutical composition comprises the raw material of Chinese medicine of following weight proportion:
。
3. a kind of pharmaceutical composition for the treatment of diabetes according to claim 1, is characterized in that, this pharmaceutical composition comprises the raw material of Chinese medicine of following weight proportion:
。
4. a kind of pharmaceutical composition for the treatment of diabetes according to claim 1, is characterized in that, this pharmaceutical composition comprises the raw material of Chinese medicine of following weight proportion:
。
5. treat the preparation method of the drug combination preparation of diabetes for one kind, it is characterized in that, this pharmaceutical composition comprises the raw material of Chinese medicine of following weight proportion, Radix Ginseng 5-15g Radix Astragali 10-20g Radix Angelicae Sinensis 10-20g Gypsum Fibrosum 10-20g Radix Rehmanniae 10-20g Rhizoma Anemarrhenae 5-15g Radix Trichosanthis 10-20g Radix Puerariae 5-15g Herba Patriniae 5-15g Herba Andrographis 5-15g Rhizoma Coptidis 5-15g Cortex Mori 10-20g Rhizoma Polygonati Odorati 10-20g Rhizoma Atractylodis Macrocephalae 5-15g Herba Taraxaci 10-20g Rhizoma Dioscoreae 10-20g Radix Ophiopogonis 10-20g Fructus Schisandrae Chinensis 5-15g Fructus Lycii 5-15g Radix Scrophulariae 5-15g Cortex Lycii 8-16g Fructus Crataegi 10-20g Radix Glycyrrhizae 5-15g Radix Rehmanniae 10-20g Stigma Maydis 15-25g,
The preparation method of described drug combination preparation is as follows: by described raw material of Chinese medicine, through grinding, grind to form powdery, then add 1200 grams of water, boil 30-40 minute, after water is opened, slow fire boils, just stop until water remains 400 grams, finally by crossing filtered through gauze, obtain filtrate.
6. the preparation method of the drug combination preparation for the treatment of diabetes according to claim 5, described preparation is oral medicine liquid.
7. the preparation method of the drug combination preparation for the treatment of diabetes according to claim 5, is characterized in that, the granularity of described grinding is 80 order-100 orders.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410131616.2A CN103920028A (en) | 2014-04-02 | 2014-04-02 | Pharmaceutical composition for treating diabetes and preparation method of preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410131616.2A CN103920028A (en) | 2014-04-02 | 2014-04-02 | Pharmaceutical composition for treating diabetes and preparation method of preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103920028A true CN103920028A (en) | 2014-07-16 |
Family
ID=51138570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410131616.2A Pending CN103920028A (en) | 2014-04-02 | 2014-04-02 | Pharmaceutical composition for treating diabetes and preparation method of preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103920028A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104352942A (en) * | 2014-11-26 | 2015-02-18 | 杨其义 | Traditional Chinese medicine composition for treating diabetes |
| CN104740308A (en) * | 2015-04-23 | 2015-07-01 | 广西达庆生物科技有限公司 | Medical biological blood sugar level reducing oral liquid and preparation method thereof |
| CN104906354A (en) * | 2015-07-06 | 2015-09-16 | 王华柱 | Traditional Chinese medicine pill for treating diabetes |
| CN105434847A (en) * | 2015-12-09 | 2016-03-30 | 杨胜祥 | Medicinal and edible health product treating diabetes |
| CN106728701A (en) * | 2017-02-27 | 2017-05-31 | 普洱淞茂滇草六味制药股份有限公司 | It is a kind of to treat pharmaceutical composition of diabetes and preparation method thereof, preparation and application |
| CN107898913A (en) * | 2017-12-30 | 2018-04-13 | 李忠能 | A kind of composition of medicine for treating diabetes and hyperlipidemia |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1200291A (en) * | 1997-07-04 | 1998-12-02 | 封振峰 | Chinese herbal medicine for treating diabetes |
| CN101698056A (en) * | 2007-11-27 | 2010-04-28 | 李斌博 | Capsules for diminishing diabetes and lowering sugar |
-
2014
- 2014-04-02 CN CN201410131616.2A patent/CN103920028A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1200291A (en) * | 1997-07-04 | 1998-12-02 | 封振峰 | Chinese herbal medicine for treating diabetes |
| CN101698056A (en) * | 2007-11-27 | 2010-04-28 | 李斌博 | Capsules for diminishing diabetes and lowering sugar |
Non-Patent Citations (1)
| Title |
|---|
| 中国中医科学院: "《中医循证临床实践指南.中医内科》", 31 January 2011 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104352942A (en) * | 2014-11-26 | 2015-02-18 | 杨其义 | Traditional Chinese medicine composition for treating diabetes |
| CN104740308A (en) * | 2015-04-23 | 2015-07-01 | 广西达庆生物科技有限公司 | Medical biological blood sugar level reducing oral liquid and preparation method thereof |
| CN104740308B (en) * | 2015-04-23 | 2018-06-01 | 广西达庆生物科技股份有限公司 | A kind of hypoglycemic oral liquid of medical bio and preparation method thereof |
| CN104906354A (en) * | 2015-07-06 | 2015-09-16 | 王华柱 | Traditional Chinese medicine pill for treating diabetes |
| CN105434847A (en) * | 2015-12-09 | 2016-03-30 | 杨胜祥 | Medicinal and edible health product treating diabetes |
| CN105434847B (en) * | 2015-12-09 | 2019-07-05 | 杨胜祥 | A kind of Chinese medicine composition for treating diabetes |
| CN106728701A (en) * | 2017-02-27 | 2017-05-31 | 普洱淞茂滇草六味制药股份有限公司 | It is a kind of to treat pharmaceutical composition of diabetes and preparation method thereof, preparation and application |
| CN107898913A (en) * | 2017-12-30 | 2018-04-13 | 李忠能 | A kind of composition of medicine for treating diabetes and hyperlipidemia |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103083531B (en) | Drug for treating diabetes | |
| CN103920028A (en) | Pharmaceutical composition for treating diabetes and preparation method of preparation thereof | |
| CN101422579B (en) | Traditional Chinese medicine preparation for treating oral ulcer | |
| CN103071128A (en) | Externally-applied plaster for curing dysmenorrhea | |
| CN104491759A (en) | Traditional Chinese medicine composition for treating cephalagra and preparation method thereof | |
| CN102743540A (en) | Combined blood sugar-reduction formula | |
| CN104491755A (en) | Traditional Chinese medicine composition for treating abdominal distension and preparation method of traditional Chinese medicine composition | |
| CN104001035A (en) | Trichosanthis Radix and Radix Puerariae-containing traditional Chinese medicinal preparation for treating type 2 diabetes mellitus | |
| CN102872425B (en) | Traditional Chinese medicine decoction for treating climacteric syndrome | |
| CN105311219A (en) | Health Jieyu Ningshen mixture | |
| CN104001078A (en) | Traditional Chinese medicine preparation for treating diabetic nephropathy and preparation method thereof | |
| CN103386024B (en) | Traditional Chinese medicine preparation for treating pancreas cancer and preparation method thereof | |
| CN104758711A (en) | Chinese herba preparation for treating pulmonary sarcoidosis and preparing method thereof | |
| CN102847061A (en) | Traditional Chinese medicine preparation for treating pediatric viral myocarditis and preparation method thereof | |
| CN102423481B (en) | Medicine for treating diabetes and preparation method thereof | |
| CN1097621A (en) | Anti-cancer powder | |
| CN104042956A (en) | Medicament for treating diabetes and preparation method thereof | |
| CN103800689A (en) | Traditional Chinese medicine composition for treating diabetes mellitus | |
| CN103933280A (en) | Traditional Chinese medicine composition for treating PCI (percutanecus coronary intervention) postoperative angina of phlegm-obstructing heart vessel type coronary heart disease and application thereof | |
| CN103251827A (en) | Traditional Chinese medicine composition for treating diabetes mellitus and preparation method thereof | |
| CN102166305B (en) | Traditional Chinese medicine composition for treating lichen planus and preparation method thereof | |
| CN101485823B (en) | Medicament for treating lung cancer and preparation method thereof | |
| CN1149095C (en) | Chinese medicine for treating baby's congenital heart disease | |
| CN104306847A (en) | Six-ingredient qi-tonifying capsule and preparation process thereof | |
| CN103263580A (en) | Traditional Chinese medicine composition for treating diabetes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140716 |