Background technology
Diabetes (Diabetes mellitus DM) are the chronic disease of a kind of complex disease because causing, mainly due to sugar, fat, protein metabolism disorder in body, clinically take blood glucose to increase with glycosuria be feature, and then can cause the synthetic disease of multisystem, many organ injuries, as diabetes merge cardiovascular, kidney; Retina and neural pathological changes, the diseases such as diabetic ketoacidosis.Being divided into clinically insulin-dependent and non-insulin-dependent diabetes mellitus (is type Ⅱdiabetes mellitus Non-Insulin Depeudent Dia betes Meuitus, NIDDM), model case many with can there is polyuria, polydipsia, polyphagia, become thin, the performance such as tired, primary disease belongs to " quenching one's thirst " category of Chinese medicine.
Along with the raising of living standards of the people,, increasing of the quickening of rhythm of life and nutrition absorption is even superfluous, the sickness rate of China's diabetes is constantly soaring, and number of patients has become a startling numeral.Diabetes and complication thereof just China people's healthy and life security in serious harm.Modern medicine it is generally acknowledged that diabetes are relevant with many factors such as body insulin deficit, insulin resistant, inherited genetic factors, hormonal readinesses, the medicines such as main application oral antidiabetic drug, euglycemic agent are treated, most of Western medicine action pathway are single, very easily cause patient's hypoglycemia, islet beta cell function exhaustion and other are as side effect such as edema, liver injury, the possibility that long-term taking needs dosage and has secondary to lose efficacy, Western medicine can not be controlled chronic complicating diseases effectively in addition.Therefore the application limitations of such chemicals is more.
Modern Chinese medicine treatment diabetes are under the guidance of differentiation of symptoms and signs for classification of syndrome thinking, use the methods such as nourishing YIN and clearing away heat, supplementing QI and nourishing YIN, blood circulation promoting and blood stasis dispelling, kidney and spleen invigorating, depressed liver-energy dispersing and QI regulating, benefiting QI for activating blood circulation, invigorating kidney, promoting blood circulation, wherein take invigorating the spleen and replenishing QI, heat clearing away YIN nourishing, blood circulation promoting and blood stasis dispelling is rule for the treatment of.Because compound of Chinese medicine can reach giving consideration to both the incidental and fundamental, in treatment primary symptom, effectively prevent and treat the complication of diabetes, and its mechanism of action and approach show as polytropism, multi-level pharmacology, be difficult for producing the situations such as insulin resistant, the advantage of compound of Chinese medicine diabetes and complication day by day manifests.At present know after deliberation have the Chinese medicine of definite curative effect to mainly contain Radix Panacis Quinquefolii, Radix Ginseng, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Notoginseng, the Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Herba Dendrobii, Radix Et Rhizoma Rhei, Herb Gynostemmae Pentaphylli, Herba Potentillae Discoloris etc.For diabetes and complication, the single medicinal material that can select is a lot, but need select the different rule for the treatment of according to clinical syndrome differentiation, so the scope of application is subject to very big limitation.
Summary of the invention
Technical problem to be solved by this invention is: a kind of medicine for the treatment of diabetes is provided, and its side effect is little, and good effect is applied widely, to overcome the deficiencies in the prior art.
The medicine that is achieved in that treatment diabetes of the present invention, calculate by weight, comprise 50~70 parts of Radix Trichosanthis, 50~70 parts, Poria, 50~70 parts, Radix Rehmanniae Preparata, 50~70 parts, the Radix Rehmanniae, 50~70 parts of Cortex Lycii, 50~70 parts of Fructus Lyciis, 50~70 parts of Radix Ophiopogonis, 50~70 parts, Gypsum Fibrosum, 50~70 parts of Rhizoma Dioscoreaes, 50~70 parts of the Radix Paeoniae Albas, 25~35 parts of the Rhizoma Anemarrhenaes, 50~70 parts of Rhizoma Coptidis, 50~70 parts of Bombyx Batryticatus, 25~35 parts of Fructus Schisandrae Chinensis, 50~70 parts of Radix Pseudostellariaes, 90~110 parts of Radix Notoginseng, 50~70 parts of Radix Salviae Miltiorrhizaes, 50~70 parts of Radix Glehniaes, 50~70 parts of Pachyrhizua angulatus, 25~35 parts of Cortex Cinnamomis, 50~70 parts of Radix Ginseng Rubra, 50~70 parts of Semen Litchis, 50~70 parts of 45~55 parts of Sanguis Draxonis and Semen Trigonellaes, and at least comprise more than one in 50~70 parts of 50~70 parts of the Radixs Astragali, 50~70 parts of Rhizoma Polygonati Odorati, 50~70 parts of Rhizoma Polygonatis or Herba Dendrobiis.
Preferred scheme is, calculate by weight, comprise 60 parts of 60 parts of Radix Trichosanthis, 60 parts, Poria, 60 parts, Radix Rehmanniae Preparata, 60 parts, the Radix Rehmanniae, 60 parts of Cortex Lycii, 60 parts of Fructus Lyciis, 60 parts of Radix Ophiopogonis, 60 parts, Gypsum Fibrosum, 60 parts of Rhizoma Dioscoreaes, 60 parts of the Radix Paeoniae Albas, 30 parts of the Rhizoma Anemarrhenaes, 60 parts of Rhizoma Coptidis, 60 parts of Bombyx Batryticatus, 30 parts of Fructus Schisandrae Chinensis, 60 parts of Radix Pseudostellariaes, 100 parts of Radix Notoginseng, 60 parts of Radix Salviae Miltiorrhizaes, 60 parts of Radix Glehniaes, 60 parts of Pachyrhizua angulatus, 30 parts of Cortex Cinnamomis, 60 parts of Radix Ginseng Rubra, 60 parts of Semen Litchis, 50 parts of Sanguis Draxonis and Semen Trigonellaes; And at least comprise more than one in 60 parts of 60 parts of the Radixs Astragali, 60 parts of Rhizoma Polygonati Odorati, 60 parts of Rhizoma Polygonatis or Herba Dendrobiis.
The preparation method of the medicine for the treatment of diabetes, getting Radix Trichosanthis, Rhizoma Polygonati Odorati, the Radix Astragali, Poria, Radix Rehmanniae Preparata, the Radix Rehmanniae, Cortex Lycii, Fructus Lycii, Radix Ophiopogonis, Gypsum Fibrosum, Rhizoma Dioscoreae, the Radix Paeoniae Alba, the Rhizoma Anemarrhenae, Herba Dendrobii, Rhizoma Coptidis, Bombyx Batryticatus, Fructus Schisandrae Chinensis, Rhizoma Polygonati, Radix Pseudostellariae, Radix Notoginseng, Radix Salviae Miltiorrhizae, Radix Glehniae, Pachyrhizua angulatus, Cortex Cinnamomi, Radix Ginseng Rubra, Semen Litchi, Sanguis Draxonis and Semen Trigonellae mixes, mixture is pulverized, get 7~9 grams of encapsulation of comminuting matter, make Chinese medicine powder.
Mixed material is crossed 100 mesh sieves after pulverizing.
The preparation method of the medicine for the treatment of diabetes, gets Radix Notoginseng and pulverizes standby, get again Radix Trichosanthis, Rhizoma Polygonati Odorati, the Radix Astragali, Poria, Radix Rehmanniae Preparata, the Radix Rehmanniae, Cortex Lycii, Fructus Lycii, Radix Ophiopogonis, Gypsum Fibrosum, Rhizoma Dioscoreae, the Radix Paeoniae Alba, the Rhizoma Anemarrhenae, Herba Dendrobii, Rhizoma Coptidis, Bombyx Batryticatus, Fructus Schisandrae Chinensis, Rhizoma Polygonati, Radix Pseudostellariae, Radix Salviae Miltiorrhizae, Radix Glehniae, Pachyrhizua angulatus, Cortex Cinnamomi, Radix Ginseng Rubra, Semen Litchi, Sanguis Draxonis and Semen Trigonellae mix, in mixture, add the water of 10~15 parts to decoct 1 hour by weight for the first time, add respectively again the decocting of 8~12 times of weight to boil twice, each decoction 35 minutes, merge decoction liquor and filter, filtrate is concentrated into thick shape again, then after cooling, add Radix Notoginseng powder to mix, make Chinese medicine preparation.
After adding Radix Notoginseng powder to mix, at 80 ℃, carry out pulverizing after drying under reduced pressure, cross 60 mesh sieves, incapsulate shell, make hard capsule.
In order to verify effect of the present invention, medicine finished product has been carried out to clinical trial, its result is as follows:
From 2006 to 2011, use this kind of drug treatment of diabetic 459 examples, women's 255 examples, male's 204 examples, in mean age 43-61 year, the course of disease is the longest 8 years the shortest half a year, and 80% left and right case concentrates on 5 years courses of disease.Upper elimination type 102 examples wherein, in side Radix Trichosanthis, Rhizoma Coptidis, Radix Ophiopogonis etc. compatibility can promoting the production of body fluid to quench thirst again can resolving heat and reducing pathogenic fire, play clearing heat and moistening lung, promoting the production of body fluid to quench thirst effect, treat and test blood sugar level after three months, there are more obvious descender's 100 examples, 1 routine blood sugar level declines slightly, and 1 routine insulin resistant patient is invalid.In type 281 examples that disappear, the heat of Gypsum Fibrosum, Rhizoma Anemarrhenae lung heat clearing stomach in side; Radix Rehmanniae, Radix Ophiopogonis lung benefiting stomach the moon, eliminating stomach-fire, the effect of YIN supplementing and fluids increasing play in full side, treat blood glucose average level after five months and reach normal level 252 examples, decline but still more higher person's 17 examples, total effective rate 95.7%, 9 examples of remaininging in 12 examples are thirsty and be hard and dry etc., and symptom is alleviated to some extent.Under type 76 examples (deficiency of both YIN and YANG 3 examples that disappear, deficiency of kidney-YIN 73 examples), after treating half a year, test result shows effective 76 examples, average fasting glucose 12.6mmol/L before treatment, post-prandial glycemia 17.1 mmol/L, average fasting glucose 7.6 mmol/L after treatment, post-prandial glycemia 11.0 mmol/L, decline respectively 39.7% and 35.7%.In above-mentioned all types of case therapeutic process, complication rate significantly lowers.
Model case
1, history so-and-so: man, 50 years old age, live Xiaohe District, Guiyang, from 3 monthly tests in 2007, find and suffer from diabetes, fasting glucose is 14.5mmol/L, post-prandial glycemia is 19.1 mmol/L.From in JIUYUE, 2007, start to take medicine of the present invention 5 months, again remove examination in hospital in February, 2008, its fasting glucose of result is 8.5mmol/L, and post-prandial glycemia is 12.1 mmol/L.
2, Song: female, 54 years old age, live Nanming District, Guiyang, from 7 monthly tests in 2005, to find and suffer from diabetes, fasting glucose is 13.3mmol/L, post-prandial glycemia is 17.5 mmol/L.From in December, 2008, start to take medicine of the present invention 5 months, again remove examination in hospital in May, 2009, its fasting glucose of result is 6.9mmol/L, and post-prandial glycemia is 10.5 mmol/L.
3, business so-and-so: man, 60 years old age, live Nanming District, Guiyang, from 7 monthly tests in 2006, find and suffer from diabetes, fasting glucose is 12.1mmol/L, post-prandial glycemia is 16.7mmol/L.From in March, 2007, start to take medicine of the present invention 3 months, again removing examination in hospital, its fasting glucose in November, 2007 is 7.3mmol/L, and post-prandial glycemia is 10.5 mmol/L.
4, Jiang: man, 45 years old age, live Yunyan District, Guiyang, 3 monthly tests in 2009 are found suffers from diabetes, and fasting glucose is 11.5mmol/L, and post-prandial glycemia is 15.8 mmol/L.From in April, 2010, start to take medicine of the present invention 3 months, again remove examination in hospital in August, 2010, its fasting glucose of result is 6.5mmol/L, and post-prandial glycemia is 10.3mmol/L.
5, deep so-and-so: female, 48 years old age, live Zunyi City, Guizhou Province, 10 monthly tests in 2008 are found suffers from diabetes, fasting glucose is 13.4mmol/L, post-prandial glycemia is 17.5 mmol/L.From in October, 2009, start to take medicine of the present invention 5 months, again remove examination in hospital in June, 2010, its fasting glucose of result is 8.1mmol/L, and post-prandial glycemia is 12.4 mmol/L.
According to the therapeutic outcome of model case, can find out, the present invention has comparatively significant hypoglycemic activity to treatment diabetics, and curative effect is fast, and because the Chinese medicinal components collocation adopting is reasonable, so side effect is little.
Owing to having adopted technique scheme, compared with prior art, the present invention adopts the screening combination that Chinese medicine formula is optimized, and obtains a kind of medicine that can be applicable to most of glycosuria patients, and this curative effect of medication is good, instant effect, and also side effect is little.The present invention is with low cost, easily implements, and result of use is very good.
The specific embodiment
Embodiments of the invention 1: the medicine for the treatment of diabetes, get 60 parts of Radix Trichosanthis, 60 parts of Rhizoma Polygonati Odorati, 60 parts of the Radixs Astragali, 60 parts, Poria, 60 parts, Radix Rehmanniae Preparata, 60 parts, the Radix Rehmanniae, 60 parts of Cortex Lycii, 60 parts of Fructus Lyciis, 60 parts of Radix Ophiopogonis, 60 parts, Gypsum Fibrosum, 60 parts of Rhizoma Dioscoreaes, 60 parts of the Radix Paeoniae Albas, 30 parts of the Rhizoma Anemarrhenaes, 60 parts of Herba Dendrobiis, 60 parts of Rhizoma Coptidis, 60 parts of Bombyx Batryticatus, 30 parts of Fructus Schisandrae Chinensis, 60 parts of Rhizoma Polygonatis, 60 parts of Radix Pseudostellariaes, 100 parts of Radix Notoginseng, 60 parts of Radix Salviae Miltiorrhizaes, 60 parts of Radix Glehniaes, 60 parts of Pachyrhizua angulatus, 30 parts of Cortex Cinnamomis, 60 parts of Radix Ginseng Rubra, 60 parts of Semen Litchis, 60 parts of mixing of 50 parts of Sanguis Draxonis and Semen Trigonellae, then with machinery, pulverize, mixed material is crossed 100 orders after pulverizing, get 7~9 grams of encapsulation of comminuting matter, make Chinese medicine powder.At morning every day, supper, within first 20 minutes, take.
Embodiments of the invention 2: the medicine for the treatment of diabetes, get 60 parts of Radix Trichosanthis, 60 parts of Rhizoma Polygonati Odorati, 60 parts, Poria, 60 parts, Radix Rehmanniae Preparata, 60 parts, the Radix Rehmanniae, 60 parts of Cortex Lycii, 60 parts of Fructus Lyciis, 60 parts of Radix Ophiopogonis, 60 parts, Gypsum Fibrosum, 60 parts of Rhizoma Dioscoreaes, 60 parts of the Radix Paeoniae Albas, 30 parts of the Rhizoma Anemarrhenaes, 60 parts of Rhizoma Coptidis, 60 parts of Bombyx Batryticatus, 30 parts of Fructus Schisandrae Chinensis, 60 parts of Radix Pseudostellariaes, 100 parts of Radix Notoginseng, 60 parts of Radix Salviae Miltiorrhizaes, 60 parts of Radix Glehniaes, 60 parts of Pachyrhizua angulatus, 30 parts of Cortex Cinnamomis, 60 parts of Radix Ginseng Rubra, 60 parts of Semen Litchis, 50 parts of Sanguis Draxonis and 60 parts of mixing of Semen Trigonellae; Then in mixture, add the water of 10~15 parts to decoct 1 hour by weight for the first time, add respectively again the decocting of 8~12 times of weight to boil twice, each decoction 35 minutes, merge decoction liquor and filter, filtrate is concentrated into thick shape again, then after cooling, add Radix Notoginseng powder to mix, make Chinese medicine preparation.At morning every day, supper, within first 20 minutes, take.
Embodiments of the invention 3: the medicine for the treatment of diabetes, get 60 parts of Radix Trichosanthis, 60 parts of Rhizoma Polygonati Odorati, 60 parts, Poria, 60 parts, Radix Rehmanniae Preparata, 60 parts, the Radix Rehmanniae, 60 parts of Cortex Lycii, 60 parts of Fructus Lyciis, 60 parts of Radix Ophiopogonis, 60 parts, Gypsum Fibrosum, 60 parts of Rhizoma Dioscoreaes, 60 parts of the Radix Paeoniae Albas, 30 parts of the Rhizoma Anemarrhenaes, 60 parts of Rhizoma Coptidis, 60 parts of Bombyx Batryticatus, 30 parts of Fructus Schisandrae Chinensis, 60 parts of Radix Pseudostellariaes, 100 parts of Radix Notoginseng, 60 parts of Radix Salviae Miltiorrhizaes, 60 parts of Radix Glehniaes, 60 parts of Pachyrhizua angulatus, 30 parts of Cortex Cinnamomis, 60 parts of Radix Ginseng Rubra, 60 parts of Semen Litchis, 50 parts of Sanguis Draxonis and 60 parts of mixing of Semen Trigonellae; Then in mixture, add the water of 10~15 parts to decoct 1 hour by weight for the first time, add respectively again the decocting of 8~12 times of weight to boil twice, decoct 35 minutes at every turn, merge decoction liquor and filter, filtrate is concentrated into thick shape again, adds Radix Notoginseng powder to mix after then cooling; At 80 ℃, carry out pulverizing after drying under reduced pressure, cross 60 mesh sieves, incapsulate shell, make hard capsule.At morning every day, supper, within first 20 minutes, take.